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Aliases for NUP58 Gene

Aliases for NUP58 Gene

  • Nucleoporin 58kDa 2 3 5
  • Nucleoporin-Like Protein 1 3 4
  • Nucleoporin Like 1 2 3
  • 58 KDa Nucleoporin 3 4
  • NUPL1 3 4
  • KIAA0410 4
  • PRO2463 3
  • NUP45 3

External Ids for NUP58 Gene

Previous HGNC Symbols for NUP58 Gene

  • NUPL1

Summaries for NUP58 Gene

Entrez Gene Summary for NUP58 Gene

  • This gene encodes a member of the nucleoporin family that shares 87% sequence identity with rat nucleoporin p58. The protein is localized to the nuclear rim and is a component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for NUP58 Gene

NUP58 (Nucleoporin 58kDa) is a Protein Coding gene. Among its related pathways are Cellular response to heat stress and Glycosaminoglycan metabolism.

UniProtKB/Swiss-Prot for NUP58 Gene

  • Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.

Gene Wiki entry for NUP58 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP58 Gene

Genomics for NUP58 Gene

Regulatory Elements for NUP58 Gene

Enhancers for NUP58 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NUP58 on UCSC Golden Path with GeneCards custom track

Promoters for NUP58 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NUP58 on UCSC Golden Path with GeneCards custom track

Genomic Location for NUP58 Gene

25,301,084 bp from pter
25,349,800 bp from pter
48,717 bases
Plus strand

Genomic View for NUP58 Gene

Genes around NUP58 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUP58 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUP58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP58 Gene

Proteins for NUP58 Gene

  • Protein details for NUP58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleoporin p58/p45
    Protein Accession:
    Secondary Accessions:
    • A6NI12
    • B4DZJ1
    • O43160
    • Q5JRG2
    • Q5JRG5

    Protein attributes for NUP58 Gene

    599 amino acids
    Molecular mass:
    60897 Da
    Quaternary structure:
    • Component of the p62 complex, a complex at least composed of NUP62, NUP54, and NUP58. Interacts with NUTF2. Interacts with SRP1-alpha and Importin p97 proteins when they are together, but not with SRP1-alpha protein alone (By similarity).
    • In rat, the p62 complex contains two different isoforms of NUP58. Isoform p45 has however not been isolated in human so far.
    • Sequence=BAA23706.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NUP58 Gene

    Alternative splice isoforms for NUP58 Gene


neXtProt entry for NUP58 Gene

Proteomics data for NUP58 Gene at MOPED

Post-translational modifications for NUP58 Gene

No data available for DME Specific Peptides for NUP58 Gene

Domains & Families for NUP58 Gene

Gene Families for NUP58 Gene

Protein Domains for NUP58 Gene


Suggested Antigen Peptide Sequences for NUP58 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains FG repeats.
  • Belongs to the NUP58 family.
  • Contains FG repeats.
  • Belongs to the NUP58 family.
genes like me logo Genes that share domains with NUP58: view

Function for NUP58 Gene

Molecular function for NUP58 Gene

GENATLAS Biochemistry:
nucleoporin,component of multiple RNA export pathway
UniProtKB/Swiss-Prot Function:
Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.
genes like me logo Genes that share phenotypes with NUP58: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUP58 Gene

Localization for NUP58 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP58 Gene

Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Biased towards cytoplasmic side. Central region of the nuclear pore complex, within the transporter (By similarity). {ECO:0000250}.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for NUP58 Gene

Pathways & Interactions for NUP58 Gene

SuperPathways for NUP58 Gene

Superpath Contained pathways
1 Regulation of Glucokinase by Glucokinase Regulatory Protein
2 Infectious disease
3 Cell Cycle, Mitotic
4 Mitotic Prophase
5 Influenza Viral RNA Transcription and Replication
genes like me logo Genes that share pathways with NUP58: view

Pathways by source for NUP58 Gene

Gene Ontology (GO) - Biological Process for NUP58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006409 tRNA export from nucleus TAS --
GO:0006606 protein import into nucleus IBA --
GO:0007077 mitotic nuclear envelope disassembly TAS --
GO:0008033 tRNA processing TAS --
genes like me logo Genes that share ontologies with NUP58: view

No data available for SIGNOR curated interactions for NUP58 Gene

Drugs & Compounds for NUP58 Gene

No Compound Related Data Available

Transcripts for NUP58 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for NUP58 Gene

No ASD Table

Relevant External Links for NUP58 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NUP58 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

genes like me logo Genes that share expression patterns with NUP58: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NUP58 Gene

Orthologs for NUP58 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUP58 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NUPL1 35
  • 89.14 (n)
  • 92.32 (a)
NUPL1 36
  • 94 (a)
(Canis familiaris)
Mammalia NUPL1 35
  • 93.75 (n)
  • 94.55 (a)
NUPL1 36
  • 95 (a)
(Mus musculus)
Mammalia Nupl1 35
  • 90.06 (n)
  • 91.82 (a)
Nupl1 16
Nupl1 36
  • 93 (a)
(Pan troglodytes)
Mammalia NUPL1 35
  • 99.72 (n)
  • 99.67 (a)
NUPL1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Nupl1 35
  • 89.91 (n)
  • 90.43 (a)
(Monodelphis domestica)
Mammalia NUPL1 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia NUPL1 36
  • 87 (a)
(Gallus gallus)
Aves NUPL1 35
  • 83.19 (n)
  • 88.61 (a)
NUPL1 36
  • 88 (a)
(Anolis carolinensis)
Reptilia NUPL1 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nupl1 35
  • 71.37 (n)
  • 75.76 (a)
Str.19038 35
(Danio rerio)
Actinopterygii Dr.4435 35
nupl1 35
  • 64.51 (n)
  • 68.7 (a)
nupl1 36
  • 66 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nup58 36
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1035 36
  • 39 (a)
Species with no ortholog for NUP58:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUP58 Gene

Gene Tree for NUP58 (if available)
Gene Tree for NUP58 (if available)

Paralogs for NUP58 Gene Pseudogenes for NUP58 Gene

genes like me logo Genes that share paralogs with NUP58: view

No data available for Paralogs for NUP58 Gene

Variants for NUP58 Gene

Sequence variations from dbSNP and Humsavar for NUP58 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
VAR_050570 -
rs12871608 - 25,313,673(+) CTGCA(C/T)CAACA reference, missense, utr-variant-5-prime
rs12491 -- 25,341,921(+) GTGCA(C/T)GTGCC intron-variant, utr-variant-3-prime
rs1129861 -- 25,335,816(+) TTAGT(A/G)TGTAT intron-variant
rs1801764 -- 25,335,847(+) ATCTT(C/T)GAGAT intron-variant

Variation tolerance for NUP58 Gene

Residual Variation Intolerance Score: 69.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.56; 82.47% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for NUP58 Gene

Disorders for NUP58 Gene

Relevant External Links for NUP58

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NUP58 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUP58 Gene

Publications for NUP58 Gene

  1. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 2 3 4 67
  2. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3

Products for NUP58 Gene

Sources for NUP58 Gene