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Aliases for NUP58 Gene

Aliases for NUP58 Gene

  • Nucleoporin 58 2 3 5
  • Nucleoporin-Like Protein 1 3 4
  • Nucleoporin Like 1 2 3
  • 58 KDa Nucleoporin 3 4
  • Nucleoporin 58kDa 2 3
  • NUPL1 3 4
  • Nucleoporin P58/P45 3
  • KIAA0410 4
  • PRO2463 3
  • NUP45 3

External Ids for NUP58 Gene

Previous HGNC Symbols for NUP58 Gene

  • NUPL1

Summaries for NUP58 Gene

Entrez Gene Summary for NUP58 Gene

  • This gene encodes a member of the nucleoporin family that shares 87% sequence identity with rat nucleoporin p58. The protein is localized to the nuclear rim and is a component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for NUP58 Gene

NUP58 (Nucleoporin 58) is a Protein Coding gene. Among its related pathways are Transport of the SLBP independent Mature mRNA and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for NUP58 Gene

  • Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.

Gene Wiki entry for NUP58 Gene

Additional gene information for NUP58 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP58 Gene

Genomics for NUP58 Gene

Regulatory Elements for NUP58 Gene

Enhancers for NUP58 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13H025300 1.3 ENCODE dbSUPER 9.2 +0.8 789 2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 SP3 SP5 CDK8 NUP58 MTMR6 ENSG00000260509 GC13P025348
GH13H025316 0.8 ENCODE dbSUPER 12.4 +17.3 17329 3 FOSL1 ZNF362 ZNF366 JUN FOS PRDM1 ATF2 MTMR6 NUP58 ATP8A2 ENSG00000260509 GC13P025348
GH13H025285 1.3 ENCODE dbSUPER 7.5 -14.1 -14129 2 HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF2 YY1 GLIS2 ZNF143 MTMR6 CENPJ NUP58 LOC105370121
GH13H025276 0.4 dbSUPER 19.2 -24.4 -24415 1 HMBOX1 NUP58 ATP8A2 LINC00463 LINC01053 MTMR6 LOC105370121
GH13H024910 1.2 FANTOM5 ENCODE 6.1 -389.8 -389779 1 PKNOX1 ATF1 FOXA2 CHAMP1 FOS USF2 ZNF592 MEF2D SMARCA4 IKZF1 NUP58 MTMR6 PARP4 PABPC3 CENPJ GC13P024791 PIR31198
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NUP58 on UCSC Golden Path with GeneCards custom track

Promoters for NUP58 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000060139 617 2200 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 FOS

Genomic Location for NUP58 Gene

Chromosome:
13
Start:
25,301,084 bp from pter
End:
25,349,800 bp from pter
Size:
48,717 bases
Orientation:
Plus strand

Genomic View for NUP58 Gene

Genes around NUP58 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUP58 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUP58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP58 Gene

Proteins for NUP58 Gene

  • Protein details for NUP58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVL2-NUP58_HUMAN
    Recommended name:
    Nucleoporin p58/p45
    Protein Accession:
    Q9BVL2
    Secondary Accessions:
    • A6NI12
    • B4DZJ1
    • O43160
    • Q5JRG2
    • Q5JRG5

    Protein attributes for NUP58 Gene

    Size:
    599 amino acids
    Molecular mass:
    60897 Da
    Quaternary structure:
    • Component of the p62 complex, a complex at least composed of NUP62, NUP54, and NUP58. Interacts with NUTF2. Interacts with SRP1-alpha and Importin p97 proteins when they are together, but not with SRP1-alpha protein alone (By similarity).
    Miscellaneous:
    • In rat, the p62 complex contains two different isoforms of NUP58. Isoform p45 has however not been isolated in human so far.
    SequenceCaution:
    • Sequence=BAA23706.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NUP58 Gene

    Alternative splice isoforms for NUP58 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUP58 Gene

Post-translational modifications for NUP58 Gene

No data available for DME Specific Peptides for NUP58 Gene

Domains & Families for NUP58 Gene

Gene Families for NUP58 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for NUP58 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NUP58 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BVL2

UniProtKB/Swiss-Prot:

NUP58_HUMAN :
  • Contains FG repeats.
  • Belongs to the NUP58 family.
Domain:
  • Contains FG repeats.
Family:
  • Belongs to the NUP58 family.
genes like me logo Genes that share domains with NUP58: view

Function for NUP58 Gene

Molecular function for NUP58 Gene

GENATLAS Biochemistry:
nucleoporin,component of multiple RNA export pathway
UniProtKB/Swiss-Prot Function:
Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.

Gene Ontology (GO) - Molecular Function for NUP58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005487 nucleocytoplasmic transporter activity IBA --
GO:0005515 protein binding IPI 17500595
GO:0008139 nuclear localization sequence binding IBA --
GO:0017056 structural constituent of nuclear pore IEA --
genes like me logo Genes that share ontologies with NUP58: view
genes like me logo Genes that share phenotypes with NUP58: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NUP58
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUP58 Gene

Localization for NUP58 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP58 Gene

Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Biased towards cytoplasmic side. Central region of the nuclear pore complex, within the transporter. {ECO:0000250 UniProtKB:P70581}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUP58 gene
Compartment Confidence
nucleus 5
mitochondrion 3
cytosol 3
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Mitochondria (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NUP58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope TAS --
GO:0005643 nuclear pore IBA,IEA --
GO:0016020 membrane IEA --
GO:0031965 nuclear membrane IEA --
genes like me logo Genes that share ontologies with NUP58: view

Pathways & Interactions for NUP58 Gene

SuperPathways for NUP58 Gene

SuperPathway Contained pathways
1 Transport of the SLBP independent Mature mRNA
2 HIV Life Cycle
.45
3 Cell Cycle, Mitotic
.60
4 Mitotic Prophase
5 Influenza Viral RNA Transcription and Replication
genes like me logo Genes that share pathways with NUP58: view

Pathways by source for NUP58 Gene

Gene Ontology (GO) - Biological Process for NUP58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006110 regulation of glycolytic process TAS --
GO:0006406 mRNA export from nucleus TAS --
GO:0006409 tRNA export from nucleus TAS --
GO:0006606 protein import into nucleus IBA --
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with NUP58: view

No data available for SIGNOR curated interactions for NUP58 Gene

Drugs & Compounds for NUP58 Gene

No Compound Related Data Available

Transcripts for NUP58 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NUP58
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NUP58 Gene

No ASD Table

Relevant External Links for NUP58 Gene

GeneLoc Exon Structure for
NUP58
ECgene alternative splicing isoforms for
NUP58

Expression for NUP58 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of NUP58 Gene:

NUP58

Evidence on tissue expression from TISSUES for NUP58 Gene

  • Nervous system(4.8)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with NUP58: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUP58 Gene

Orthologs for NUP58 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUP58 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUPL1 33 34
  • 99.72 (n)
dog
(Canis familiaris)
Mammalia NUPL1 33 34
  • 93.75 (n)
mouse
(Mus musculus)
Mammalia Nupl1 33 16 34
  • 90.06 (n)
rat
(Rattus norvegicus)
Mammalia Nupl1 33
  • 89.91 (n)
cow
(Bos Taurus)
Mammalia NUPL1 33 34
  • 89.14 (n)
oppossum
(Monodelphis domestica)
Mammalia NUPL1 34
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUPL1 34
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUPL1 33 34
  • 83.19 (n)
lizard
(Anolis carolinensis)
Reptilia NUPL1 34
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nupl1 33
  • 71.37 (n)
Str.19038 33
zebrafish
(Danio rerio)
Actinopterygii nupl1 33 34
  • 64.51 (n)
Dr.4435 33
fruit fly
(Drosophila melanogaster)
Insecta Nup58 34
  • 24 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1035 34
  • 39 (a)
OneToOne
Species where no ortholog for NUP58 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUP58 Gene

ENSEMBL:
Gene Tree for NUP58 (if available)
TreeFam:
Gene Tree for NUP58 (if available)

Paralogs for NUP58 Gene

Pseudogenes.org Pseudogenes for NUP58 Gene

genes like me logo Genes that share paralogs with NUP58: view

No data available for Paralogs for NUP58 Gene

Variants for NUP58 Gene

Sequence variations from dbSNP and Humsavar for NUP58 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000002976 -- 25,328,759(+) TTCAA(A/G)GTAAG intron-variant
rs1000023868 -- 25,326,337(+) CCTTC(-/TTT)TTTTT intron-variant
rs1000107024 -- 25,335,429(+) ATGTT(A/G)AAGAA intron-variant
rs1000129962 -- 25,335,107(+) TGTTA(C/T)ACATT intron-variant
rs1000183170 -- 25,332,029(+) TTATT(G/T)ACTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUP58 Gene

Variant ID Type Subtype PubMed ID
esv2747161 CNV deletion 23290073
esv3582237 CNV gain 25503493
nsv435952 OTHER inversion 17901297
nsv561352 CNV loss 21841781
nsv974065 CNV duplication 23825009

Variation tolerance for NUP58 Gene

Residual Variation Intolerance Score: 69.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.56; 82.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUP58 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUP58

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUP58 Gene

Disorders for NUP58 Gene

Relevant External Links for NUP58

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUP58
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUP58

No disorders were found for NUP58 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUP58 Gene

Publications for NUP58 Gene

  1. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. (PMID: 27107012) Yachie N … Roth FP (Molecular systems biology 2016) 3 60

Products for NUP58 Gene

Sources for NUP58 Gene

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