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Aliases for NUP54 Gene

Aliases for NUP54 Gene

  • Nucleoporin 54kDa 2 3
  • 54 KDa Nucleoporin 4
  • Nucleoporin 54kD 2

External Ids for NUP54 Gene

Previous GeneCards Identifiers for NUP54 Gene

  • GC04M076931
  • GC04M077225
  • GC04M077428
  • GC04M077494
  • GC04M077392
  • GC04M077035
  • GC04M072788

Summaries for NUP54 Gene

Entrez Gene Summary for NUP54 Gene

  • The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. This gene encodes a member of the phe-gly (FG) repeat-containing nucleoporin subset. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013]

GeneCards Summary for NUP54 Gene

NUP54 (Nucleoporin 54kDa) is a Protein Coding gene. Among its related pathways are Disease and Cell Cycle, Mitotic. GO annotations related to this gene include nucleocytoplasmic transporter activity.

UniProtKB/Swiss-Prot for NUP54 Gene

  • Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.

Gene Wiki entry for NUP54 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP54 Gene

Genomics for NUP54 Gene

Regulatory Elements for NUP54 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NUP54 Gene

Start:
76,114,659 bp from pter
End:
76,148,515 bp from pter
Size:
33,857 bases
Orientation:
Minus strand

Genomic View for NUP54 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUP54 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP54 Gene

Proteins for NUP54 Gene

  • Protein details for NUP54 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z3B4-NUP54_HUMAN
    Recommended name:
    Nucleoporin p54
    Protein Accession:
    Q7Z3B4
    Secondary Accessions:
    • B2RCK7
    • B4DT35
    • Q96EA7
    • Q9NVL5
    • Q9P0I1

    Protein attributes for NUP54 Gene

    Size:
    507 amino acids
    Molecular mass:
    55435 Da
    Quaternary structure:
    • Component of the p62 complex, a complex composed of NUP62, NUP54, and the isoform p58 and isoform p45 of NUPL1.
    SequenceCaution:
    • Sequence=BAA91735.1; Type=Frameshift; Positions=479; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NUP54 Gene

    Alternative splice isoforms for NUP54 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUP54 Gene

Proteomics data for NUP54 Gene at MOPED

Post-translational modifications for NUP54 Gene

Other Protein References for NUP54 Gene

No data available for DME Specific Peptides for NUP54 Gene

Domains for NUP54 Gene

Protein Domains for NUP54 Gene

Suggested Antigen Peptide Sequences for NUP54 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z3B4

UniProtKB/Swiss-Prot:

NUP54_HUMAN :
  • Q7Z3B4
Domain:
  • Contains FG repeats
Family:
  • Belongs to the NUP54 family.
genes like me logo Genes that share domains with NUP54: view

No data available for Gene Families for NUP54 Gene

Function for NUP54 Gene

Molecular function for NUP54 Gene

UniProtKB/Swiss-Prot Function: Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.

Gene Ontology (GO) - Molecular Function for NUP54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005487 nucleocytoplasmic transporter activity IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with NUP54: view

Phenotypes for NUP54 Gene

genes like me logo Genes that share phenotypes with NUP54: view

Animal Model Products

CRISPR Products

miRNA for NUP54 Gene

miRTarBase miRNAs that target NUP54

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NUP54 Gene

Localization for NUP54 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP54 Gene

Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Biased towards cytoplasmic side. Central region of the nuclear pore complex, within the transporter (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUP54 Gene COMPARTMENTS Subcellular localization image for NUP54 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NUP54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope TAS --
GO:0005643 nuclear pore IEA --
GO:0005654 nucleoplasm TAS 8707840
GO:0005737 cytoplasm TAS 8707840
GO:0031965 nuclear membrane IEA --
genes like me logo Genes that share ontologies with NUP54: view

Pathways for NUP54 Gene

SuperPathways for NUP54 Gene

genes like me logo Genes that share pathways with NUP54: view

Pathways by source for NUP54 Gene

42 Reactome pathways for NUP54 Gene
1 KEGG pathway for NUP54 Gene

Gene Ontology (GO) - Biological Process for NUP54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0005975 carbohydrate metabolic process TAS --
GO:0006605 protein targeting IEA --
GO:0006913 nucleocytoplasmic transport IEA --
GO:0007077 mitotic nuclear envelope disassembly TAS --
genes like me logo Genes that share ontologies with NUP54: view

Transcripts for NUP54 Gene

Unigene Clusters for NUP54 Gene

Nucleoporin 54kDa:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NUP54

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUP54 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13a · 13b ^
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - - - -
SP5: - -
SP6: - - - - -
SP7: - - - - - - - - - - - - - - - - - -
SP8: - - - - - - -
SP9: - -
SP10: - - - - -
SP11: -
SP12: - - -
SP13: - -
SP14:
SP15: - - - - - - - -
SP16:

ExUns: 14a · 14b · 14c · 14d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for NUP54 Gene

GeneLoc Exon Structure for
NUP54
ECgene alternative splicing isoforms for
NUP54

Expression for NUP54 Gene

mRNA expression in normal human tissues for NUP54 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUP54 Gene

SOURCE GeneReport for Unigene cluster for NUP54 Gene Hs.430435

genes like me logo Genes that share expressions with NUP54: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NUP54 Gene

Orthologs for NUP54 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUP54 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUP54 35
  • 99.71 (n)
  • 99.78 (a)
NUP54 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 92 (a)
OneToMany
NUP54 35
  • 93.25 (n)
  • 96.95 (a)
NUP54 36
  • 92 (a)
OneToMany
dog
(Canis familiaris)
Mammalia NUP54 35
  • 91.29 (n)
  • 94.12 (a)
NUP54 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nup54 35
  • 87.87 (n)
  • 96.08 (a)
Nup54 16
Nup54 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NUP54 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUP54 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nup54 35
  • 88.16 (n)
  • 96.08 (a)
chicken
(Gallus gallus)
Aves NUP54 35
  • 80.02 (n)
  • 91 (a)
NUP54 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUP54 36
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68541 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nup54 35
  • 75.29 (n)
  • 83.99 (a)
Str.1826 35
zebrafish
(Danio rerio)
Actinopterygii nup54 35
  • 62.09 (n)
  • 70.1 (a)
NUP54 36
  • 46 (a)
OneToOne
wufp63g06 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006031 35
  • 48.26 (n)
  • 40.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nup54 35
  • 49.06 (n)
  • 40.83 (a)
Nup54 36
  • 31 (a)
OneToOne
CG8831 37
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea npp-1 36
  • 21 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToMany
-- 36
  • 42 (a)
OneToMany
Species with no ortholog for NUP54:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUP54 Gene

ENSEMBL:
Gene Tree for NUP54 (if available)
TreeFam:
Gene Tree for NUP54 (if available)

Paralogs for NUP54 Gene

Selected SIMAP similar genes for NUP54 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with NUP54: view

No data available for Paralogs for NUP54 Gene

Variants for NUP54 Gene

Sequence variations from dbSNP and Humsavar for NUP54 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs4730 -- 76,114,975(-) CAGAA(C/G)AAACT utr-variant-3-prime, nc-transcript-variant
rs9652 -- 76,114,761(+) AAGTA(A/G)TTTTG utr-variant-3-prime, nc-transcript-variant
rs10654 -- 76,114,742(+) AATGG(A/T)TGCAA utr-variant-3-prime, nc-transcript-variant
rs735696 -- 76,145,980(+) TCACC(C/T)ACAGT intron-variant
rs735697 -- 76,146,215(+) AACAT(A/G)TTACA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NUP54 Gene

Variant ID Type Subtype PubMed ID
nsv7363 OTHER Inversion 18451855
nsv470047 CNV Gain 18288195
nsv461558 CNV Gain 19166990
esv275315 CNV Gain+Loss 21479260

Relevant External Links for NUP54 Gene

HapMap Linkage Disequilibrium report
NUP54

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUP54 Gene

Disorders for NUP54 Gene

No disorders were found for NUP54 Gene.

No data available for UniProtKB/Swiss-Prot for NUP54 Gene

Publications for NUP54 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins. (PMID: 8707840) Hu T. … Gerace L. (J. Cell Biol. 1996) 2 3
  3. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  4. Gradient of increasing affinity of importin beta for nucleoporins along the pathway of nuclear import. (PMID: 11266456) Ben-Efraim I. … Gerace L. (J. Cell Biol. 2001) 3
  5. Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1. (PMID: 12228227) Le Rouzic E. … Benichou S. (J. Biol. Chem. 2002) 3

Products for NUP54 Gene

Sources for NUP54 Gene

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