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Aliases for NUP43 Gene

Aliases for NUP43 Gene

  • Nucleoporin 43kDa 2 3 5
  • Nup107-160 Subcomplex Subunit Nup43 3 4
  • P42 3 4
  • BA350J20.1 3

External Ids for NUP43 Gene

Previous GeneCards Identifiers for NUP43 Gene

  • GC06M150000
  • GC06M150078
  • GC06M150076
  • GC06M150137
  • GC06M150087
  • GC06M147611
  • GC06M150045

Summaries for NUP43 Gene

Entrez Gene Summary for NUP43 Gene

  • Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP43 is part of one such subcomplex, Nup107-160 (Loiodice et al., 2004 [PubMed 15146057]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NUP43 Gene

NUP43 (Nucleoporin 43kDa) is a Protein Coding gene. Among its related pathways are RNA transport and Regulation of Glucokinase by Glucokinase Regulatory Protein.

UniProtKB/Swiss-Prot for NUP43 Gene

  • Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation.

Gene Wiki entry for NUP43 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP43 Gene

Genomics for NUP43 Gene

Regulatory Elements for NUP43 Gene

Enhancers for NUP43 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NUP43 on UCSC Golden Path with GeneCards custom track

Genomic Location for NUP43 Gene

Chromosome:
6
Start:
149,724,315 bp from pter
End:
149,749,665 bp from pter
Size:
25,351 bases
Orientation:
Minus strand

Genomic View for NUP43 Gene

Genes around NUP43 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUP43 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUP43 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP43 Gene

Proteins for NUP43 Gene

  • Protein details for NUP43 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFH3-NUP43_HUMAN
    Recommended name:
    Nucleoporin Nup43
    Protein Accession:
    Q8NFH3
    Secondary Accessions:
    • B4E2F0
    • Q9H8S0

    Protein attributes for NUP43 Gene

    Size:
    380 amino acids
    Molecular mass:
    42151 Da
    Quaternary structure:
    • Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex includes NUP160, NUP133, NUP107, NUP98, NUP85, NUP43, NUP37, SEH1 and SEC13.
    SequenceCaution:
    • Sequence=BAB14536.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NUP43 Gene

    Alternative splice isoforms for NUP43 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUP43 Gene

Proteomics data for NUP43 Gene at MOPED

Post-translational modifications for NUP43 Gene

  • Ubiquitination at Lys 196
  • Modification sites at PhosphoSitePlus

Other Protein References for NUP43 Gene

No data available for DME Specific Peptides for NUP43 Gene

Domains & Families for NUP43 Gene

Gene Families for NUP43 Gene

Protein Domains for NUP43 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NFH3

UniProtKB/Swiss-Prot:

NUP43_HUMAN :
  • Contains 6 WD repeats.
Similarity:
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with NUP43: view

Function for NUP43 Gene

Molecular function for NUP43 Gene

UniProtKB/Swiss-Prot Function:
Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation.
genes like me logo Genes that share phenotypes with NUP43: view

Animal Model Products

miRNA for NUP43 Gene

miRTarBase miRNAs that target NUP43

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUP43 Gene

Localization for NUP43 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP43 Gene

Chromosome, centromere, kinetochore. Nucleus, nuclear pore complex.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUP43 Gene COMPARTMENTS Subcellular localization image for NUP43 gene
Compartment Confidence
cytosol 5
nucleus 5
plasma membrane 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for NUP43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031080 nuclear pore outer ring NAS 15146057
genes like me logo Genes that share ontologies with NUP43: view

Pathways & Interactions for NUP43 Gene

SuperPathways for NUP43 Gene

Superpath Contained pathways
1 Regulation of Glucokinase by Glucokinase Regulatory Protein
2 Infectious disease
.48
3 Cell Cycle, Mitotic
.61
4 Mitotic Prophase
5 Influenza Viral RNA Transcription and Replication
genes like me logo Genes that share pathways with NUP43: view

Pathways by source for NUP43 Gene

Gene Ontology (GO) - Biological Process for NUP43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006409 tRNA export from nucleus TAS --
GO:0007059 chromosome segregation IEA --
GO:0007062 sister chromatid cohesion TAS --
GO:0007067 mitotic nuclear division IEA --
genes like me logo Genes that share ontologies with NUP43: view

No data available for SIGNOR curated interactions for NUP43 Gene

Drugs & Compounds for NUP43 Gene

No Compound Related Data Available

Transcripts for NUP43 Gene

Unigene Clusters for NUP43 Gene

Nucleoporin 43kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUP43 Gene

No ASD Table

Relevant External Links for NUP43 Gene

GeneLoc Exon Structure for
NUP43
ECgene alternative splicing isoforms for
NUP43

Expression for NUP43 Gene

mRNA expression in normal human tissues for NUP43 Gene

Protein differential expression in normal tissues from HIPED for NUP43 Gene

This gene is overexpressed in Breast (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUP43 Gene



SOURCE GeneReport for Unigene cluster for NUP43 Gene Hs.510375

genes like me logo Genes that share expression patterns with NUP43: view

Protein tissue co-expression partners for NUP43 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NUP43 Gene

Orthologs for NUP43 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUP43 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NUP43 35
  • 91.05 (n)
  • 94.21 (a)
NUP43 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUP43 35
  • 92.46 (n)
  • 95 (a)
NUP43 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nup43 35
  • 88.77 (n)
  • 93.68 (a)
Nup43 16
Nup43 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NUP43 35
  • 99.74 (n)
  • 99.74 (a)
NUP43 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nup43 35
  • 88.83 (n)
  • 92.61 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 89 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia NUP43 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUP43 35
  • 75.13 (n)
  • 76.47 (a)
NUP43 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUP43 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nup43 35
  • 68.72 (n)
  • 69.71 (a)
Str.1191 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.25711 35
zebrafish
(Danio rerio)
Actinopterygii Dr.16507 35
nup43 35
  • 62.07 (n)
  • 62.7 (a)
nup43 36
  • 62 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9079 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000480 35
  • 38.92 (n)
  • 26.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nup43 35
  • 44.41 (n)
  • 28.86 (a)
Nup43 36
  • 28 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToOne
Species with no ortholog for NUP43:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUP43 Gene

ENSEMBL:
Gene Tree for NUP43 (if available)
TreeFam:
Gene Tree for NUP43 (if available)

Paralogs for NUP43 Gene

Pseudogenes.org Pseudogenes for NUP43 Gene

genes like me logo Genes that share paralogs with NUP43: view

No data available for Paralogs for NUP43 Gene

Variants for NUP43 Gene

Sequence variations from dbSNP and Humsavar for NUP43 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1048113 -- 149,724,613(-) gagca(A/G)aacgc nc-transcript-variant, utr-variant-3-prime
rs1048114 -- 149,724,612(-) agcaa(A/G)acgcc nc-transcript-variant, utr-variant-3-prime
rs1048117 -- 149,724,592(-) aaTAT(A/G)CATAT nc-transcript-variant, utr-variant-3-prime
rs1048137 -- 149,724,611(-) gcaaa(A/G)cgcca nc-transcript-variant, utr-variant-3-prime
rs1057724 -- 149,725,825(+) ATAAA(G/T)ATGGT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NUP43 Gene

Variant ID Type Subtype PubMed ID
nsv886762 CNV Loss 21882294
esv2732861 CNV Deletion 23290073
nsv436520 CNV Deletion 17901297

Variation tolerance for NUP43 Gene

Residual Variation Intolerance Score: 42.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.40; 54.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUP43 Gene

HapMap Linkage Disequilibrium report
NUP43

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUP43 Gene

Disorders for NUP43 Gene

Relevant External Links for NUP43

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUP43

No disorders were found for NUP43 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUP43 Gene

Publications for NUP43 Gene

  1. Proteomic analysis of the mammalian nuclear pore complex. (PMID: 12196509) Cronshaw J.M. … Matunis M.J. (J. Cell Biol. 2002) 2 3 4 67
  2. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Crystal structure of human nuclear pore complex component NUP43. (PMID: 26391640) Xu C. … Min J. (FEBS Lett. 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for NUP43 Gene

Sources for NUP43 Gene

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