Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



NUP37 Gene

protein-coding   GIFtS: 54
GCID: GC12M102467

Nucleoporin 37kDa

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Nucleoporin 37kDa1 2
p372 3 5
Nup107-160 Subcomplex Subunit Nup372 3
Nucleoporin Nup372

External Ids:    HGNC: 299291   Entrez Gene: 790232   Ensembl: ENSG000000751887   OMIM: 6092645   UniProtKB: Q8NFH43   

Export aliases for NUP37 gene to outside databases

Previous GC identifers: GC12M100971 GC12M100972 GC12M099527


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for NUP37 Gene:
Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes
(NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP37 is part of one such
subcomplex, Nup107-160 (Loiodice et al., 2004 (PubMed 15146057)).(supplied by OMIM, Mar 2008)

GeneCards Summary for NUP37 Gene:
NUP37 (nucleoporin 37kDa) is a protein-coding gene. Diseases associated with NUP37 include ehrlichiosis, and influenza.

UniProtKB/Swiss-Prot: NUP37_HUMAN, Q8NFH4
Function: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is
required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore
microtubule attachment, mitotic progression and chromosome segregation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NUP37 gene promoter:
         AML1a   CUTL1   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   NF-AT   C/EBPalpha   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNUP37 promoter sequence
   Search Chromatin IP Primers for NUP37

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NUP37


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.2   Ensembl cytogenetic band:  12q23.2   HGNC cytogenetic band: 12q23

NUP37 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUP37 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M102467:  view genomic region     (about GC identifiers)

Start:
102,467,967 bp from pter      End:
102,513,902 bp from pter
Size:
45,936 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NUP37_HUMAN, Q8NFH4 (See protein sequence)
Recommended Name: Nucleoporin Nup37  
Size: 326 amino acids; 36708 Da
Subunit: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex
includes NUP160, NUP133, NUP107, NUP98, NUP85, NUP43, NUP37, SEH1 and SEC13
Sequence caution: Sequence=BAB15422.1; Type=Erroneous initiation;
Secondary accessions: Q9H644

Explore the universe of human proteins at neXtProt for NUP37: NX_Q8NFH4

Explore proteomics data for NUP37 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys94, Lys114, Lys186
  • Modification sites at PhosphoSitePlus

  • See NUP37 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_076962.2  
    ENSEMBL proteins: 
     ENSP00000448054   ENSP00000447284   ENSP00000448086   ENSP00000449982   ENSP00000251074  
    Reactome Protein details: Q8NFH4

    NUP37 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for NUP37
    OriGene Protein Over-expression Lysate for NUP37
    OriGene MassSpec for NUP37
    OriGene Custom Protein Services for NUP37
    GenScript Custom Purified and Recombinant Proteins Services for NUP37
    Novus Biologicals NUP37 Protein
    Novus Biologicals NUP37 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NUP37

    NUP37 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NUP37
    Novus Biologicals NUP37 Antibody
    Search for Antibodies for NUP37 at Abcam
    Cloud-Clone Corp. Antibodies for NUP37
    ThermoFisher Antibodies for NUP37
    Search LSBio for Antibodies for NUP37

    NUP37 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NUP37
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NUP37
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NUP37
    Cloud-Clone Corp. CLIAs for NUP37


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    WDR: WD repeat domain containing

    4 InterPro protein domains:
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q8NFH4

    ProtoNet protein and cluster: Q8NFH4

    UniProtKB/Swiss-Prot: NUP37_HUMAN, Q8NFH4
    Similarity: Contains 4 WD repeats


    NUP37 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NUP37_HUMAN, Q8NFH4
    Function: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is
    required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore
    microtubule attachment, mitotic progression and chromosome segregation

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15146057
         
    NUP37 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NUP37:
     Increased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NUP37
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NUP37

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NUP37
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NUP37

    miRNA
    Products:
        
    miRTarBase miRNAs that target NUP37:
    hsa-mir-10a-5p (MIRT047580), hsa-mir-193b-3p (MIRT041410)

    Block miRNA regulation of human, mouse, rat NUP37 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate NUP37
    SwitchGear 3'UTR luciferase reporter plasmidNUP37 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NUP37
    Predesigned siRNA for gene silencing in human, mouse, rat NUP37

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NUP37

    Clone
    Products:
         
    OriGene clones in human, mouse for NUP37 (see all 6)
    OriGene ORF clones in mouse, rat for NUP37
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NUP37 (NM_024057)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUP37
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUP37

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NUP37
    Browse ESI BIO Cell Lines and PureStem Progenitors for NUP37 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUP37


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    NUP37_HUMAN, Q8NFH4: Chromosome, centromere, kinetochore. Nucleus, nuclear pore complex
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    extracellular1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000776colocalizes with kinetochore IDA15146057
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0005634nucleus IDA--
    GO:0005635nuclear envelope TAS--
    GO:0005730NOT nucleolus IDA--

    NUP37 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for NUP37 About   (see all 16)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Regulation of Glucokinase by Glucokinase Regulatory Protein
    Transport of the SLBP Dependant Mature mRNA0.92
    Export of Viral Ribonucleoproteins from Nucleus0.88
    Transport of Mature mRNAs Derived from Intronless Transcripts0.92
    Transport of Ribonucleoproteins into the Host Nucleus0.88
    Transport of the SLBP independent Mature mRNA0.91
    Regulation of Glucokinase by Glucokinase Regulatory Protein0.87
    Nuclear import of Rev protein0.91
    Glucose transport0.87
    2HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    Host Interactions of HIV factors0.60
    3Interferon Signaling
    Interferon Signaling0.59
    ISG15 antiviral mechanism0.42
    Cytokine Signaling in Immune system0.59
    Antiviral mechanism by IFN-stimulated genes0.42
    4Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    5Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected Reactome Pathways for NUP37 (see all 9)
        Rev-mediated nuclear export of HIV RNA
    Regulation of Glucokinase by Glucokinase Regulatory Protein
    Nuclear Pore Complex (NPC) Disassembly
    Nuclear import of Rev protein
    Resolution of Sister Chromatid Cohesion


    1 Kegg Pathway  (Kegg details for NUP37):
        RNA transport


    NUP37 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NUP37
    Interactions:

        Search GeneGlobe Interaction Network for NUP37

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NUP37 (Q8NFH42, 3 ENSP000002510744) via UniProtKB, MINT, STRING, and/or I2D (see all 706)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NUP107P577403, ENSP000002291794I2D: score=1 STRING: ENSP00000229179
    NUP43Q8NFH33, ENSP000003422624I2D: score=1 STRING: ENSP00000342262
    NUP85Q9BW273, ENSP000002455444I2D: score=1 STRING: ENSP00000245544
    SEC13P557353, ENSP000003121224I2D: score=1 STRING: ENSP00000312122
    AURKBQ96GD42, ENSP000003139504MINT-7945693 STRING: ENSP00000313950
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0007059chromosome segregation IEA--
    GO:0007067mitosis IEA--
    GO:0007077mitotic nuclear envelope disassembly TAS--

    NUP37 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NUP37



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for NUP37 gene: 
    NM_024057.2  

    Unigene Cluster for NUP37:

    Nucleoporin 37kDa
    Hs.444276  [show with all ESTs]
    Unigene Representative Sequence: BU535474
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000546385 ENST00000552283(uc001tjc.3) ENST00000547269 ENST00000551744
    ENST00000551200(uc009zub.1) ENST00000543021 ENST00000548994 ENST00000550459
    ENST00000251074
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NUP37 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate NUP37
    SwitchGear 3'UTR luciferase reporter plasmidNUP37 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NUP37
    Predesigned siRNA for gene silencing in human, mouse, rat NUP37
    Clone
    Products:
         
    OriGene clones in human, mouse for NUP37 (see all 6)
    OriGene ORF clones in mouse, rat for NUP37
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NUP37 (NM_024057)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUP37
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUP37
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for NUP37
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat NUP37
      QuantiTect SYBR Green Assays in human, mouse, rat NUP37
      QuantiFast Probe-based Assays in human, mouse, rat NUP37

    Additional mRNA sequence: 

    AF514994.1 AK026271.1 AK296733.1 AK310619.1 BC000861.2 

    6 DOTS entries:

    DT.443427  DT.75101830  DT.99944956  DT.100779052  DT.92426051  DT.92027114 

    Selected AceView cDNA sequences (see all 122):

    BM995521 AK026271 BM907179 AI377046 BM840012 BQ421921 BU179266 NM_024057 
    AI192424 AI567451 BG743307 BM906963 CK820042 AA872406 BM463297 CD250898 
    BU622817 AA417762 BQ020631 BQ632136 BC000861 BU626052 BX352968 AI718619 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for NUP37    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
    SP1:              -                                   -                                 
    SP2:              -                                   -                                 
    SP3:                                                                                    
    SP4:                                                                                    


    ECgene alternative splicing isoforms for NUP37

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    NUP37 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTTCTGTAG
    NUP37 Expression
    About this image

    NUP37 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NUP37 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.444276
        Custom PCR Arrays for NUP37
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for NUP37
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat NUP37
    QuantiTect SYBR Green Assays in human, mouse, rat NUP37
    QuantiFast Probe-based Assays in human, mouse, rat NUP37
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUP37

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for NUP37 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nup371 , 5 nucleoporin 371, 5 88.14(n)1
    91.1(a)1
      10 (43.70 cM)5
    697361  NM_027191.21  NP_081467.21 
     881469925 
    chicken
    (Gallus gallus)
    Aves NUP371 nucleoporin 37kDa 78.53(n)
    78.22(a)
      418093  NM_001277392.1  NP_001264321.1 
    lizard
    (Anolis carolinensis)
    Reptilia NUP376
    nucleoporin 37kDa
    75(a)
    1 ↔ 1
    5(17510554-17536135)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.32082 Transcribed sequences 72.81(n)    BX706316.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.165532 Transcribed sequence with moderate similarity to protein more 73.38(n)    BM141470.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG118751 CG11875 42.96(n)
    33.1(a)
      43040  NM_143103.4  NP_651360.1 


    ENSEMBL Gene Tree for NUP37 (if available)
    TreeFam Gene Tree for NUP37 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for NUP37 (see all 824)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1119081251,2
    C,F--102467704(+) AGCCTC/TCCAAA 1 -- int11Minor allele frequency- T:0.50WA 2
    rs1995591311,2
    --102467927(+) TAAAA-/ATATATA 1 -- int10--------
    rs2009656051,2
    --102467940(+) TATAT-/ACACACA 1 -- int10--------
    rs116096181,2
    C,F,A,H--102467941(+) ATATAC/TACACA 1 -- int13Minor allele frequency- T:0.02NS NA 244
    rs1463780911,2
    C--102467948(+) CACAC-/AGAGAAC 1 -- int10--------
    rs745596211,2
    C,F--102468002(+) ATAAAC/AGCAAC 1 -- ut312Minor allele frequency- A:0.33WA CSA 3
    rs1861044411,2
    C--102468096(+) TAAAAA/CTACAA 1 -- ut310--------
    rs3731414021,2
    C--102468103(+) ACAAAA/GTTTGT 1 -- ut310--------
    rs1500837541,2
    C,F--102468130(+) AAACAC/ATTTAT 1 -- ut311Minor allele frequency- A:0.00NA 4548
    rs2005457371,2
    --102468219(+) GATCCA/GACGGC 2 V syn10--------

    HapMap Linkage Disequilibrium report for NUP37 (102467967 - 102513902 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NUP37:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv899473CNV Loss21882294
    nsv899472CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NUP37
    DNA2.0 Custom Variant and Variant Library Synthesis for NUP37

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609264    OMIM disorders: --

    5 diseases for NUP37:    About MalaCards
    ehrlichiosis    influenza    hiv-1    malaria
    hepatitis

    1 disease from the University of Copenhagen DISEASES database for NUP37:
    Ehrlichiosis

    NUP37 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NUP37
    Human Genome Epidemiology (HuGE) Navigator: NUP37 (1 document)

    Export disorders for NUP37 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for NUP37 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with NUP37)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Proteomic analysis of the mammalian nuclear pore complex. (PubMed id 12196509)1, 2, 3 Cronshaw J.M.... Matunis M.J. (J. Cell Biol. 2002)
    2. Identification of 15 loci influencing height in a Korean population. (PubMed id 19893584)1, 4 Kim J.J....Lee J.K. (J. Hum. Genet. 2010)
    3. Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160 subcomplex. (PubMed id 17360435)1, 2 Glavy J.S.... Chait B.T. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    4. The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions. (PubMed id 17363900)1, 2 Zuccolo M.... Doye V. (EMBO J. 2007)
    5. The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis. (PubMed id 15146057)1, 2 Loieodice I.... Doye V. (Mol. Biol. Cell 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Molecular basis for Nup37 and ELY5/ELYS recruitment to the nuclear pore complex. (PubMed id 22955883)1 Bilokapic S. and Schwartz T.U. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Proteomics strategy to identify substrates of LNX, a PDZ domain-containing E3 ubiquitin ligase. (PubMed id 22889411)1 Guo Z....Gao Y. (J. Proteome Res. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 79023 HGNC: 29929 AceView: NUP37 Ensembl:ENSG00000075188 euGenes: HUgn79023
    ECgene: NUP37 Kegg: 79023 H-InvDB: NUP37

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for NUP37 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NUP37 gene:
    Search GeneIP for patents involving NUP37

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for NUP37  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for NUP37  
     OriGene MassSpec something-or-other for NUP37   OriGene clones in human, mouse for NUP37  
     OriGene qSTAR qPCR primer pairs in human, mouse for NUP37   OriGene Purified Protein for NUP37  
     OriGene ORF clones in mouse, rat for NUP37   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NUP37   OriGene Custom Protein Services for NUP37  

     
     
     Block miRNA regulation of human, mouse, rat NUP37 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NUP37
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NUP37 Predesigned siRNA for gene silencing in human, mouse, rat NUP37
     QuantiFast Probe-based Assays in human, mouse, rat NUP37 QuantiTect SYBR Green Assays in human, mouse, rat NUP37
     Custom PCR Arrays for NUP37 Search Chromatin IP Primers for NUP37
     Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat NUP37 Search GeneGlobe Interaction Network for NUP37
     Regulatory tfbs in NUP37 promoter
     GenScript Custom Purified and Recombinant Proteins Services for NUP37 GenScript cDNA clones with any tag delivered in your preferred vector for NUP37
     GenScript Custom Assay Services for NUP37 GenScript Custom overexpressing Cell Line Services for NUP37
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for NUP37
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     NUP37 antibodies
     NUP37 proteins
     NUP37 lysates
     Search for Antibodies for NUP37 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for NUP37
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for NUP37
     Antibodies for NUP37
     ELISAs for NUP37
     CLIAs for NUP37



     Browse ESI BIO Cell Lines and PureStem Progenitors for NUP37
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUP37
     SwitchGear 3'UTR luciferase reporter plasmids for NUP37
     SwitchGear Promoter luciferase reporter plasmids for NUP37
     ThermoFisher Antibodies for NUP37
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUP37
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NUP37
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NUP37
     Search LSBio for Antibodies for NUP37
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NUP37 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4