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Aliases for NUP37 Gene

Aliases for NUP37 Gene

  • Nucleoporin 37 2 3 5
  • Nup107-160 Subcomplex Subunit Nup37 3 4
  • Nucleoporin 37kDa 2 3
  • P37 3 4
  • Nucleoporin Nup37 3

External Ids for NUP37 Gene

Previous GeneCards Identifiers for NUP37 Gene

  • GC12M100971
  • GC12M100972
  • GC12M102467
  • GC12M099527

Summaries for NUP37 Gene

Entrez Gene Summary for NUP37 Gene

  • Nuclear pore complexes (NPCs) are used for transporting macromolecules between the cytoplasm and the nucleus. NPCs consist of multiple copies of 30 distinct proteins (nucleoporins), which assemble into biochemically-separable subcomplexes. The protein encoded by this gene is part of a subcomplex (Nup107-160) that is required for proper NPC function as well as for normal kinetochore-microtubule interaction and mitosis. [provided by RefSeq, Dec 2015]

GeneCards Summary for NUP37 Gene

NUP37 (Nucleoporin 37) is a Protein Coding gene. Among its related pathways are Transport of the SLBP independent Mature mRNA and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for NUP37 Gene

  • Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation.

Additional gene information for NUP37 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP37 Gene

Genomics for NUP37 Gene

Regulatory Elements for NUP37 Gene

Enhancers for NUP37 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H102060 1.1 ENCODE 22.3 +58.5 58465 2 HDGF PKNOX1 FOXA2 ATF1 ARID4B SIN3A DMAP1 BRCA1 YY1 ETS1 WASHC3 UTP20 NUP37 ENSG00000257222 ST13P22 PARPBP NENFP2
GH12H101875 1.5 FANTOM5 ENCODE 11.7 +242.8 242792 4 HDGF ARNT ARID4B SIN3A DMAP1 ZNF207 ZNF143 SP3 ZHX2 REST DRAM1 ENSG00000257222 UTP20 CHPT1 ST13P22 NUP37 PARPBP GNPTAB PIR46358
GH12H101669 1.1 Ensembl ENCODE 15.7 +449.8 449768 0 PKNOX1 ARNT ZSCAN4 ZSCAN9 RAD21 RUNX3 ZNF654 MCM3 CEBPB REST LOC105369936 NUP37 ENSG00000257222 CHPT1 UTP20 SYCP3 GC12P101665 ENSG00000274560
GH12H101279 1 ENCODE 12.8 +839.9 839913 1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ETS1 SLC30A9 ZNF143 ATF7 ARL1 UTP20 ENSG00000257222 NUP37
GH12H101828 1 ENCODE 11.7 +290.3 290332 3 ARNT ARID4B SIN3A ZNF121 GTF3C2 GLIS2 ZNF143 ATF7 RUNX3 SP3 CHPT1 GNPTAB ENSG00000257222 ST13P22 UTP20 NUP37 RNU6-172P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NUP37 on UCSC Golden Path with GeneCards custom track

Promoters for NUP37 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000056353 -161 2201 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B CBX5 ZNF143 FOS SP3 MXD4

Genomic Location for NUP37 Gene

Chromosome:
12
Start:
102,073,103 bp from pter
End:
102,120,139 bp from pter
Size:
47,037 bases
Orientation:
Minus strand

Genomic View for NUP37 Gene

Genes around NUP37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUP37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUP37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP37 Gene

Proteins for NUP37 Gene

  • Protein details for NUP37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFH4-NUP37_HUMAN
    Recommended name:
    Nucleoporin Nup37
    Protein Accession:
    Q8NFH4
    Secondary Accessions:
    • Q9H644

    Protein attributes for NUP37 Gene

    Size:
    326 amino acids
    Molecular mass:
    36708 Da
    Quaternary structure:
    • Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex includes NUP160, NUP133, NUP107, NUP98, NUP85, NUP43, NUP37, SEH1 and SEC13.
    SequenceCaution:
    • Sequence=BAB15422.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NUP37 Gene

neXtProt entry for NUP37 Gene

Post-translational modifications for NUP37 Gene

  • Ubiquitination at posLast=9494, Lys114, and posLast=186186
  • Modification sites at PhosphoSitePlus

Other Protein References for NUP37 Gene

No data available for DME Specific Peptides for NUP37 Gene

Domains & Families for NUP37 Gene

Gene Families for NUP37 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for NUP37 Gene

Suggested Antigen Peptide Sequences for NUP37 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NUP37: view

No data available for UniProtKB/Swiss-Prot for NUP37 Gene

Function for NUP37 Gene

Molecular function for NUP37 Gene

UniProtKB/Swiss-Prot Function:
Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation.

Phenotypes From GWAS Catalog for NUP37 Gene

Gene Ontology (GO) - Molecular Function for NUP37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15146057
genes like me logo Genes that share ontologies with NUP37: view

Phenotypes for NUP37 Gene

GenomeRNAi human phenotypes for NUP37:
genes like me logo Genes that share phenotypes with NUP37: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NUP37
  • Applied Biological Materials Clones for NUP37
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUP37 Gene

Localization for NUP37 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP37 Gene

Chromosome, centromere, kinetochore. Nucleus, nuclear pore complex.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUP37 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NUP37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 colocalizes_with kinetochore IEA,IDA 15146057
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus IDA,IEA 21630459
GO:0005635 nuclear envelope TAS --
GO:0005643 nuclear pore IEA --
genes like me logo Genes that share ontologies with NUP37: view

Pathways & Interactions for NUP37 Gene

SuperPathways for NUP37 Gene

SuperPathway Contained pathways
1 Transport of the SLBP independent Mature mRNA
2 HIV Life Cycle
.45
3 Cell Cycle, Mitotic
.60
4 Mitotic Prophase
5 Influenza Viral RNA Transcription and Replication
genes like me logo Genes that share pathways with NUP37: view

Pathways by source for NUP37 Gene

Gene Ontology (GO) - Biological Process for NUP37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006110 regulation of glycolytic process TAS --
GO:0006406 mRNA export from nucleus TAS --
GO:0006409 tRNA export from nucleus TAS --
GO:0006810 transport IEA --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with NUP37: view

No data available for SIGNOR curated interactions for NUP37 Gene

Drugs & Compounds for NUP37 Gene

No Compound Related Data Available

Transcripts for NUP37 Gene

Unigene Clusters for NUP37 Gene

Nucleoporin 37kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NUP37
  • Applied Biological Materials Clones for NUP37
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NUP37 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: - -
SP2: - -
SP3:
SP4:

Relevant External Links for NUP37 Gene

GeneLoc Exon Structure for
NUP37
ECgene alternative splicing isoforms for
NUP37

Expression for NUP37 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUP37 Gene

Protein differential expression in normal tissues from HIPED for NUP37 Gene

This gene is overexpressed in Serum (19.0) and Liver (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NUP37 Gene



Protein tissue co-expression partners for NUP37 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NUP37 Gene:

NUP37

SOURCE GeneReport for Unigene cluster for NUP37 Gene:

Hs.444276

Evidence on tissue expression from TISSUES for NUP37 Gene

  • Intestine(4.2)
genes like me logo Genes that share expression patterns with NUP37: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUP37 Gene

Orthologs for NUP37 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUP37 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUP37 33 34
  • 99.9 (n)
dog
(Canis familiaris)
Mammalia NUP37 33 34
  • 93.66 (n)
cow
(Bos Taurus)
Mammalia NUP37 33 34
  • 92.54 (n)
mouse
(Mus musculus)
Mammalia Nup37 33 16 34
  • 88.14 (n)
rat
(Rattus norvegicus)
Mammalia Nup37 33
  • 87.53 (n)
oppossum
(Monodelphis domestica)
Mammalia NUP37 34
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUP37 34
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUP37 33 34
  • 78.53 (n)
lizard
(Anolis carolinensis)
Reptilia NUP37 34
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nup37 33
  • 71.78 (n)
Str.3208 33
zebrafish
(Danio rerio)
Actinopterygii nup37 33 34
  • 65.85 (n)
Dr.16553 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011887 33
  • 43.79 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11875 33 34
  • 42.96 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 32 (a)
OneToOne
Species where no ortholog for NUP37 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUP37 Gene

ENSEMBL:
Gene Tree for NUP37 (if available)
TreeFam:
Gene Tree for NUP37 (if available)

Paralogs for NUP37 Gene

No data available for Paralogs for NUP37 Gene

Variants for NUP37 Gene

Sequence variations from dbSNP and Humsavar for NUP37 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000082842 -- 102,097,118(+) CAAAT(A/G)ACAGA intron-variant
rs1000154175 -- 102,103,899(+) CACAG(C/G)TAACA intron-variant
rs1000231368 -- 102,090,422(+) ATTTG(C/T)TGCAT intron-variant
rs1000271222 -- 102,110,548(+) TAGCA(A/G)ATATT intron-variant
rs1000325937 -- 102,116,458(+) CTTTT(A/T)ATGAT intron-variant

Variation tolerance for NUP37 Gene

Residual Variation Intolerance Score: 55.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.77; 16.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUP37 Gene

Human Gene Mutation Database (HGMD)
NUP37
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUP37

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NUP37 Gene

Disorders for NUP37 Gene

Relevant External Links for NUP37

Genetic Association Database (GAD)
NUP37
Human Genome Epidemiology (HuGE) Navigator
NUP37
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUP37

No disorders were found for NUP37 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUP37 Gene

Publications for NUP37 Gene

  1. Proteomic analysis of the mammalian nuclear pore complex. (PMID: 12196509) Cronshaw JM … Matunis MJ (The Journal of cell biology 2002) 2 3 4 60
  2. Identification of 15 loci influencing height in a Korean population. (PMID: 19893584) Kim JJ … Lee JK (Journal of human genetics 2010) 3 45 60
  3. Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160 subcomplex. (PMID: 17360435) Glavy JS … Chait BT (Proceedings of the National Academy of Sciences of the United States of America 2007) 3 4 60
  4. The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions. (PMID: 17363900) Zuccolo M … Doye V (The EMBO journal 2007) 3 4 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for NUP37 Gene

  • Addgene plasmids for NUP37

Sources for NUP37 Gene

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