Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NUP37 Gene

Aliases for NUP37 Gene

  • Nucleoporin 37kDa 2 3
  • P37 3 4 6
  • Nup107-160 Subcomplex Subunit Nup37 3 4
  • Nucleoporin Nup37 3

External Ids for NUP37 Gene

Summaries for NUP37 Gene

Entrez Gene Summary for NUP37 Gene

  • Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP37 is part of one such subcomplex, Nup107-160 (Loiodice et al., 2004 [PubMed 15146057]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NUP37 Gene

NUP37 (Nucleoporin 37kDa) is a Protein Coding gene. Among its related pathways are Disease and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for NUP37 Gene

  • Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP37 Gene

Genomics for NUP37 Gene

Genomic Location for NUP37 Gene

Start:
102,073,103 bp from pter
End:
102,120,247 bp from pter
Size:
47,145 bases
Orientation:
Minus strand

Genomic View for NUP37 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUP37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP37 Gene

Regulatory Elements for NUP37 Gene

Proteins for NUP37 Gene

  • Protein details for NUP37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFH4-NUP37_HUMAN
    Recommended name:
    Nucleoporin Nup37
    Protein Accession:
    Q8NFH4
    Secondary Accessions:
    • Q9H644

    Protein attributes for NUP37 Gene

    Size:
    326 amino acids
    Molecular mass:
    36708 Da
    Quaternary structure:
    • Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex includes NUP160, NUP133, NUP107, NUP98, NUP85, NUP43, NUP37, SEH1 and SEC13.
    SequenceCaution:
    • Sequence=BAB15422.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for NUP37 Gene

Proteomics data for NUP37 Gene at MOPED

Post-translational modifications for NUP37 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys94, Lys114, and Lys186

Other Protein References for NUP37 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NUP37 Gene

Domains for NUP37 Gene

Gene Families for NUP37 Gene

HGNC:
  • WDR :WD repeat domain containing

Protein Domains for NUP37 Gene

UniProtKB/Swiss-Prot:

NUP37_HUMAN
Similarity:
  • Contains 7 WD repeats.:
    • Q8NFH4
genes like me logo Genes that share domains with NUP37: view

Function for NUP37 Gene

Molecular function for NUP37 Gene

UniProtKB/Swiss-Prot Function: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation.

Gene Ontology (GO) - Molecular Function for NUP37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15146057
genes like me logo Genes that share ontologies with NUP37: view

Phenotypes for NUP37 Gene

GenomeRNAi human phenotypes for NUP37:
genes like me logo Genes that share phenotypes with NUP37: view

miRNA for NUP37 Gene

miRTarBase miRNAs that target NUP37

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NUP37 Gene

Localization for NUP37 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP37 Gene

Chromosome, centromere, kinetochore. Nucleus, nuclear pore complex.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUP37 Gene COMPARTMENTS Subcellular localization image for NUP37 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NUP37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 colocalizes_with kinetochore IDA 15146057
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus IDA 21630459
GO:0005635 nuclear envelope TAS --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with NUP37: view

Pathways for NUP37 Gene

SuperPathways for NUP37 Gene

genes like me logo Genes that share pathways with NUP37: view

Pathways by source for NUP37 Gene

47 Reactome pathways for NUP37 Gene
1 KEGG pathway for NUP37 Gene

Gene Ontology (GO) - Biological Process for NUP37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0005975 carbohydrate metabolic process TAS --
GO:0007059 chromosome segregation IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0007077 mitotic nuclear envelope disassembly TAS --
genes like me logo Genes that share ontologies with NUP37: view

Transcripts for NUP37 Gene

Unigene Clusters for NUP37 Gene

Nucleoporin 37kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUP37 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: - -
SP2: - -
SP3:
SP4:

Relevant External Links for NUP37 Gene

GeneLoc Exon Structure for
NUP37
ECgene alternative splicing isoforms for
NUP37

Expression for NUP37 Gene

mRNA expression in normal human tissues for NUP37 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUP37 Gene

SOURCE GeneReport for Unigene cluster for NUP37 Gene Hs.444276

genes like me logo Genes that share expressions with NUP37: view

Orthologs for NUP37 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUP37 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUP37 36
  • 99.9 (n)
  • 100 (a)
NUP37 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NUP37 36
  • 92.54 (n)
  • 94.79 (a)
NUP37 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUP37 36
  • 93.66 (n)
  • 94.17 (a)
NUP37 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nup37 36
  • 88.14 (n)
  • 91.1 (a)
Nup37 16
Nup37 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NUP37 37
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUP37 37
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nup37 36
  • 87.53 (n)
  • 89.26 (a)
chicken
(Gallus gallus)
Aves NUP37 36
  • 78.53 (n)
  • 78.22 (a)
NUP37 37
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUP37 37
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nup37 36
  • 71.78 (n)
  • 70.55 (a)
Str.3208 36
zebrafish
(Danio rerio)
Actinopterygii Dr.16553 36
nup37 36
  • 65.85 (n)
  • 69.02 (a)
nup37 37
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011887 36
  • 43.79 (n)
  • 33.1 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11875 36
  • 42.96 (n)
  • 33.1 (a)
CG11875 37
  • 31 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 32 (a)
OneToOne
Species with no ortholog for NUP37:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUP37 Gene

ENSEMBL:
Gene Tree for NUP37 (if available)
TreeFam:
Gene Tree for NUP37 (if available)

Paralogs for NUP37 Gene

No data available for Paralogs for NUP37 Gene

Variants for NUP37 Gene

Sequence variations from dbSNP and Humsavar for NUP37 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1509671 -- 102,095,374(-) GTATA(G/T)GCATA intron-variant
rs2136510 -- 102,111,825(-) TTCAC(C/T)GAATT intron-variant
rs2271266 -- 102,112,266(-) TTCTC(A/G)TTACT intron-variant
rs2465233 -- 102,105,750(-) ccgag(C/T)agctg intron-variant
rs2465234 -- 102,085,765(+) TTAAG(C/G)TTATT splice-donor-variant

Structural Variations from Database of Genomic Variants (DGV) for NUP37 Gene

Variant ID Type Subtype PubMed ID
nsv899472 CNV Gain 21882294
nsv899473 CNV Loss 21882294

Relevant External Links for NUP37 Gene

HapMap Linkage Disequilibrium report
NUP37
Human Gene Mutation Database (HGMD)
NUP37

Disorders for NUP37 Gene

(1) University of Copenhagen DISEASES for NUP37 Gene

Relevant External Links for NUP37

Genetic Association Database (GAD)
NUP37
Human Genome Epidemiology (HuGE) Navigator
NUP37
genes like me logo Genes that share disorders with NUP37: view

No data available for UniProtKB/Swiss-Prot for NUP37 Gene

Publications for NUP37 Gene

  1. Proteomic analysis of the mammalian nuclear pore complex. (PMID: 12196509) Cronshaw J.M. … Matunis M.J. (J. Cell Biol. 2002) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis. (PMID: 15146057) Loieodice I. … Doye V. (Mol. Biol. Cell 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160 subcomplex. (PMID: 17360435) Glavy J.S. … Chait B.T. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 4

Products for NUP37 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate NUP37
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for NUP37
    • Block miRNA regulation of NUP37 using miScript Target Protectors

    Sources for NUP37 Gene

    Back to Top

    Content