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Aliases for NUP35 Gene

Aliases for NUP35 Gene

  • Nucleoporin 35 2 3 5
  • Mitotic Phosphoprotein 44 2 3 4
  • Nuclear Pore Complex Protein Nup53 3 4
  • Nucleoporin 35kDa 2 3
  • MP-44 3 4
  • NUP53 3 4
  • MP44 3 4
  • 35 KDa Nucleoporin 4
  • Nucleoporin NUP53 3
  • Nucleoporin Nup35 4
  • NP44 3

External Ids for NUP35 Gene

Previous GeneCards Identifiers for NUP35 Gene

  • GC02P184192
  • GC02P183814
  • GC02P183697
  • GC02P183982
  • GC02P175847

Summaries for NUP35 Gene

Entrez Gene Summary for NUP35 Gene

  • This gene encodes a member of the nucleoporin family. The encoded protein contains two membrane binding regions, is localized to the nuclear rim, and is part of the nuclear pore complex. All molecules entering or leaving the nucleus either diffuse through or are actively transported by the nuclear pore complex. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 7 and 10. [provided by RefSeq, Dec 2013]

GeneCards Summary for NUP35 Gene

NUP35 (Nucleoporin 35) is a Protein Coding gene. Among its related pathways are Interferon gamma signaling and Transport of the SLBP independent Mature mRNA.

UniProtKB/Swiss-Prot for NUP35 Gene

  • Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs). Can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC.

Gene Wiki entry for NUP35 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP35 Gene

Genomics for NUP35 Gene

Regulatory Elements for NUP35 Gene

Enhancers for NUP35 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F183034 1.1 ENCODE 25.2 -80.3 -80323 4.8 PKNOX1 ZFP64 ARID4B SIN3A YY1 CBX5 ZNF143 FOS KLF13 ZNF263 NUP35 FRZB NCKAP1 ENSG00000202141 GC02M183023
GH02F183078 1.1 ENCODE 23 -38.4 -38389 1.9 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 FOS NFYC REST SMARCB1 NUP35 NCKAP1 ENSG00000224643 DUSP19 FRZB
GH02F183070 1.1 Ensembl ENCODE 16.5 -46.1 -46109 0.8 ELF3 DRAP1 CTCF SAP130 ARID4B ZNF48 ZSCAN9 RAD21 TEAD3 GATAD1 NUP35 KRT8P10 GC02M183065 ENSG00000221498
GH02F183123 1.1 ENCODE 13.6 +7.6 7593 3.0 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 DUSP19 NUP35 LOC105373774 GC02P183146
GH02F183091 0.7 ENCODE 11.1 -26.0 -25953 0.1 DRAP1 ATF1 SAP130 NFYC ARID4B DMAP1 ZNF644 IRF1 NR2F6 HOMEZ ENSG00000221498 NUP35 DUSP19 ENSG00000224643
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NUP35 on UCSC Golden Path with GeneCards custom track

Genomic Location for NUP35 Gene

Chromosome:
2
Start:
183,117,490 bp from pter
End:
183,161,684 bp from pter
Size:
44,195 bases
Orientation:
Plus strand

Genomic View for NUP35 Gene

Genes around NUP35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUP35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUP35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP35 Gene

Proteins for NUP35 Gene

  • Protein details for NUP35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFH5-NUP53_HUMAN
    Recommended name:
    Nucleoporin NUP53
    Protein Accession:
    Q8NFH5
    Secondary Accessions:
    • B4DP57
    • B4DYB4
    • Q4ZFZ9
    • Q53S95
    • Q8TDJ1

    Protein attributes for NUP35 Gene

    Size:
    326 amino acids
    Molecular mass:
    34774 Da
    Quaternary structure:
    • Interacts with TMEM48/NDC1. Forms a complex with NUP93, NUP155, NUP205 and lamin B; the interaction with NUP93 is direct.

    Three dimensional structures from OCA and Proteopedia for NUP35 Gene

    Alternative splice isoforms for NUP35 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUP35 Gene

Post-translational modifications for NUP35 Gene

  • Ubiquitination at Lys 269 and Lys 294
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NUP35 Gene

Domains & Families for NUP35 Gene

Gene Families for NUP35 Gene

Protein Domains for NUP35 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NFH5

UniProtKB/Swiss-Prot:

NUP53_HUMAN :
  • Contains 1 RRM Nup35-type domain.
  • Belongs to the Nup53 family.
Domain:
  • Contains 1 RRM Nup35-type domain.
Family:
  • Belongs to the Nup53 family.
genes like me logo Genes that share domains with NUP35: view

Function for NUP35 Gene

Molecular function for NUP35 Gene

UniProtKB/Swiss-Prot Function:
Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs). Can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC.

Gene Ontology (GO) - Molecular Function for NUP35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003697 single-stranded DNA binding IBA --
GO:0005487 nucleocytoplasmic transporter activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0005543 phospholipid binding IBA --
genes like me logo Genes that share ontologies with NUP35: view
genes like me logo Genes that share phenotypes with NUP35: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUP35 Gene

Localization for NUP35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP35 Gene

Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein. Note=Tightly associated with the nuclear membrane and lamina. {ECO:0000269 PubMed:15703211}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUP35 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for NUP35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope TAS --
GO:0005643 nuclear pore IEA --
GO:0005652 nuclear lamina IEA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with NUP35: view

Pathways & Interactions for NUP35 Gene

SuperPathways for NUP35 Gene

SuperPathway Contained pathways
1 Transport of the SLBP independent Mature mRNA
2 HIV Life Cycle
.45
3 Cell Cycle, Mitotic
.60
4 Mitotic Prophase
5 Influenza Viral RNA Transcription and Replication
genes like me logo Genes that share pathways with NUP35: view

Pathways by source for NUP35 Gene

Gene Ontology (GO) - Biological Process for NUP35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0006406 mRNA export from nucleus TAS --
GO:0006409 tRNA export from nucleus TAS --
GO:0006607 NLS-bearing protein import into nucleus IBA --
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with NUP35: view

No data available for SIGNOR curated interactions for NUP35 Gene

Transcripts for NUP35 Gene

Unigene Clusters for NUP35 Gene

Nucleoporin 35kDa:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUP35 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10
SP1: - - -
SP2: - - - - -
SP3: - - - -
SP4: - -
SP5: - - - - - - -
SP6: -
SP7:

Relevant External Links for NUP35 Gene

GeneLoc Exon Structure for
NUP35
ECgene alternative splicing isoforms for
NUP35

Expression for NUP35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NUP35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NUP35 Gene

This gene is overexpressed in Testis (10.4), Peripheral blood mononuclear cells (9.8), and Liver (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NUP35 Gene



Protein tissue co-expression partners for NUP35 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NUP35 Gene:

NUP35

SOURCE GeneReport for Unigene cluster for NUP35 Gene:

Hs.180591
genes like me logo Genes that share expression patterns with NUP35: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NUP35 Gene

Orthologs for NUP35 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUP35 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUP35 34 35
  • 99.8 (n)
dog
(Canis familiaris)
Mammalia NUP35 34 35
  • 94.61 (n)
mouse
(Mus musculus)
Mammalia Gm4353 35
  • 93 (a)
OneToMany
Nup35 34 16 35
  • 88.31 (n)
cow
(Bos Taurus)
Mammalia NUP35 34 35
  • 92.84 (n)
oppossum
(Monodelphis domestica)
Mammalia NUP35 35
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nup35 34
  • 89.23 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 86 (a)
OneToMany
-- 35
  • 84 (a)
OneToMany
chicken
(Gallus gallus)
Aves NUP35 34 35
  • 77.06 (n)
lizard
(Anolis carolinensis)
Reptilia NUP35 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nup35 34
  • 74.32 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC64281 34
zebrafish
(Danio rerio)
Actinopterygii nup35 34 35
  • 70.43 (n)
wufj68d11 34
fruit fly
(Drosophila melanogaster)
Insecta CG6540 34 35
  • 40.37 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008619 34
  • 39.96 (n)
worm
(Caenorhabditis elegans)
Secernentea npp-19 35
  • 20 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10509 35
  • 42 (a)
OneToOne
Species where no ortholog for NUP35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUP35 Gene

ENSEMBL:
Gene Tree for NUP35 (if available)
TreeFam:
Gene Tree for NUP35 (if available)

Paralogs for NUP35 Gene

Pseudogenes.org Pseudogenes for NUP35 Gene

genes like me logo Genes that share paralogs with NUP35: view

No data available for Paralogs for NUP35 Gene

Variants for NUP35 Gene

Sequence variations from dbSNP and Humsavar for NUP35 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1006141 -- 183,139,834(+) gactt(C/T)gggcc intron-variant
rs1006142 -- 183,139,844(+) ctcca(G/T)aattt intron-variant
rs10165922 -- 183,120,863(+) ACGGG(G/T)AGGTT intron-variant
rs10167583 -- 183,153,448(+) gggtt(A/G)tagga intron-variant
rs10167838 -- 183,146,329(+) TAGAA(C/T)TAATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUP35 Gene

Variant ID Type Subtype PubMed ID
esv2668397 CNV deletion 23128226
esv26746 CNV loss 19812545
esv2763287 CNV gain+loss 21179565
esv3593580 CNV gain 21293372
esv3593582 CNV loss 21293372
esv3593583 CNV loss 21293372
esv3893517 CNV gain+loss 25118596
nsv1009882 CNV gain 25217958
nsv1109318 CNV deletion 24896259
nsv1138873 CNV deletion 24896259

Variation tolerance for NUP35 Gene

Residual Variation Intolerance Score: 30.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUP35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUP35

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUP35 Gene

Disorders for NUP35 Gene

Relevant External Links for NUP35

Genetic Association Database (GAD)
NUP35
Human Genome Epidemiology (HuGE) Navigator
NUP35
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUP35

No disorders were found for NUP35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUP35 Gene

Publications for NUP35 Gene

  1. The conserved transmembrane nucleoporin NDC1 is required for nuclear pore complex assembly in vertebrate cells. (PMID: 16600873) Mansfeld J. … Antonin W. (Mol. Cell 2006) 3 4 64
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  3. Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex. (PMID: 15703211) Hawryluk-Gara L.A. … Wozniak R.W. (Mol. Biol. Cell 2005) 3 4 64
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for NUP35 Gene

Sources for NUP35 Gene

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