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NUP35 Gene

protein-coding   GIFtS: 54
GCID: GC02P183982

Nucleoporin 35kDa

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Nucleoporin 35kDa1 2     NUP532 3
Mitotic Phosphoprotein 442 3     NP442 5
Nuclear Pore Complex Protein Nup532 3     Nucleoporin NUP532
MP-442 3     35 KDa Nucleoporin3
MP442 3     Nucleoporin Nup353

External Ids:    HGNC: 297971   Entrez Gene: 1294012   Ensembl: ENSG000001630027   OMIM: 6081405   UniProtKB: Q8NFH53   
ORGUL members:         

Export aliases for NUP35 gene to outside databases

Previous GC identifers: GC02P184192 GC02P183814 GC02P183697 GC02P175847


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NUP35 Gene:
This gene encodes a member of the nucleoporin family. The encoded protein contains two membrane binding regions,
is localized to the nuclear rim, and is part of the nuclear pore complex. All molecules entering or leaving the
nucleus either diffuse through or are actively transported by the nuclear pore complex. Alternative splicing
results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 7 and 10.
(provided by RefSeq, Dec 2013)

GeneCards Summary for NUP35 Gene:
NUP35 (nucleoporin 35kDa) is a protein-coding gene.

UniProtKB/Swiss-Prot: NUP53_HUMAN, Q8NFH5
Function: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as
nucleoporins (NUPs). Can play the role of both NPC structural components and of docking or interaction partners
for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC

Gene Wiki entry for NUP35 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NUP35 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   AML1a   POU2F2   FOXL1   SRY   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNUP35 promoter sequence
   Search Chromatin IP Primers for NUP35

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NUP35


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32.1   Ensembl cytogenetic band:  2q32.1   HGNC cytogenetic band: 2q32

NUP35 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUP35 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P183982:  view genomic region     (about GC identifiers)

Start:
183,982,241 bp from pter      End:
184,026,408 bp from pter
Size:
44,168 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NUP53_HUMAN, Q8NFH5 (See protein sequence)
Recommended Name: Nucleoporin NUP53  
Size: 326 amino acids; 34774 Da
Subunit: Interacts with TMEM48/NDC1. Forms a complex with NUP93, NUP155, NUP205 and lamin B; the interaction with
NUP93 is direct
1 PDB 3D structure from and Proteopedia for NUP35:
4LIR (3D)    
Secondary accessions: Q4ZFZ9 Q53S95 Q8TDJ1

Explore the universe of human proteins at neXtProt for NUP35: NX_Q8NFH5

Explore proteomics data for NUP35 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys269, Lys294
  • Modification sites at PhosphoSitePlus

  • See NUP35 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001274513.1  NP_001274514.1  NP_612142.2  

    ENSEMBL proteins: 
     ENSP00000403819   ENSP00000412554   ENSP00000387305   ENSP00000393130   ENSP00000295119  
     ENSP00000364066   ENSP00000412311   ENSP00000442019  
    Reactome Protein details: Q8NFH5

    NUP35 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for NUP35

     
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    antibodies-online proteins for NUP35 (7 products) 

     
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    antibodies-online antibodies for NUP35 (30 products) 

    NUP35 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR017389 Nucleoporin_NUP53
     IPR007846 RRM_NUP35_dom

    Graphical View of Domain Structure for InterPro Entry Q8NFH5

    ProtoNet protein and cluster: Q8NFH5

    UniProtKB/Swiss-Prot: NUP53_HUMAN, Q8NFH5
    Similarity: Belongs to the Nup53 family
    Similarity: Contains 1 RRM Nup35-type domain


    Find genes that share domains with NUP35           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NUP53_HUMAN, Q8NFH5
    Function: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as
    nucleoporins (NUPs). Can play the role of both NPC structural components and of docking or interaction partners
    for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC

    Animal Models:

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NUP35
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    hsa-let-7b-5p (MIRT032327)

    Block miRNA regulation of human, mouse, rat NUP35 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NUP35 (see all 11):
    hsa-miR-20a hsa-miR-519d hsa-miR-187* hsa-miR-1283 hsa-miR-106a hsa-miR-106b hsa-miR-410 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidNUP35 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: NUP35 (NM_138285)
    Sino Biological Human cDNA Clone for NUP35
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUP35

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NUP53_HUMAN, Q8NFH5: Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein. Note=Tightly
    associated with the nuclear membrane and lamina
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    plasma membrane4
    cytosol2

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005635nuclear envelope TAS--
    GO:0005643nuclear pore IEA--
    GO:0005730NOT nucleolus IDA--
    GO:0005886plasma membrane IDA--

    Find genes that share ontologies with NUP35           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NUP35 About   (see all 14)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Regulation of Glucokinase by Glucokinase Regulatory Protein
    Transport of the SLBP Dependant Mature mRNA0.92
    Export of Viral Ribonucleoproteins from Nucleus0.88
    Transport of Mature mRNAs Derived from Intronless Transcripts0.92
    Transport of Ribonucleoproteins into the Host Nucleus0.88
    Transport of the SLBP independent Mature mRNA0.91
    Regulation of Glucokinase by Glucokinase Regulatory Protein0.87
    Nuclear import of Rev protein0.91
    Glucose transport0.87
    2HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    Host Interactions of HIV factors0.60
    3Interferon Signaling
    Interferon Signaling0.59
    ISG15 antiviral mechanism0.42
    Cytokine Signaling in Immune system0.59
    Antiviral mechanism by IFN-stimulated genes0.42
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    5Transport of Mature Transcript to Cytoplasm
    Transport of Mature Transcript to Cytoplasm0.93
    Transport of Mature mRNA derived from an Intron-Containing Transcript0.93


    Find genes that share SuperPaths with NUP35           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    Selected Reactome Pathways for NUP35 (see all 6)
        Rev-mediated nuclear export of HIV RNA
    Regulation of Glucokinase by Glucokinase Regulatory Protein
    Nuclear import of Rev protein
    Nuclear Pore Complex (NPC) Disassembly
    Vpr-mediated nuclear import of PICs


    1 Kegg Pathway  (Kegg details for NUP35):
        RNA transport

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NUP35
    Interactions:

        Search GeneGlobe Interaction Network for NUP35

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NUP35 (ENSP000002951194) via UniProtKB, MINT, STRING, and/or I2D (see all 80)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AAASENSP000002098734STRING: ENSP00000209873
    ALYREFENSP000003318174STRING: ENSP00000331817
    BANF1ENSP000003102754STRING: ENSP00000310275
    CDC40ENSP000003043704STRING: ENSP00000304370
    CPSF2ENSP000002988754STRING: ENSP00000298875
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0007077mitotic nuclear envelope disassembly TAS--
    GO:0008645hexose transport TAS--
    GO:0010827regulation of glucose transport TAS--

    Find genes that share ontologies with NUP35           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NUP35 (NUP53)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NUP35 gene (4 alternative transcripts): 
    NM_001287584.1  NM_001287585.1  NM_138285.4  NM_001008544.1  

    Unigene Cluster for NUP35:

    Nucleoporin 35kDa
    Hs.180591  [show with all ESTs]
    Unigene Representative Sequence: BC111016
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000442895 ENST00000446612 ENST00000409798 ENST00000472844 ENST00000455063
    ENST00000295119(uc010zfs.2 uc002upf.3 uc010zft.2 uc002upg.3)
    ENST00000497330 ENST00000374930 ENST00000479162 ENST00000452137 ENST00000541912

    miRNA
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    Block miRNA regulation of human, mouse, rat NUP35 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NUP35 (see all 11):
    hsa-miR-20a hsa-miR-519d hsa-miR-187* hsa-miR-1283 hsa-miR-106a hsa-miR-106b hsa-miR-410 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidNUP35 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NUP35
    Clone
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    GenScript: all cDNA clones in your preferred vector: NUP35 (NM_138285)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUP35
    Primer
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    OriGene qPCR primer pairs and template standards for NUP35
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat NUP35
      QuantiTect SYBR Green Assays in human, mouse, rat NUP35
      QuantiFast Probe-based Assays in human, mouse, rat NUP35

    Additional mRNA sequence: 

    AF411516.1 AF514993.1 AK289601.1 AK290760.1 AK298199.1 AK302350.1 BC022333.1 BC035597.1 
    BC047029.1 BC061698.1 BC111016.1 

    7 DOTS entries:

    DT.415692  DT.92439428  DT.92439430  DT.86858290  DT.102827351  DT.120944993  DT.95271139 

    Selected AceView cDNA sequences (see all 149):

    BC035597 AA805736 CR619859 N59330 Z43996 CR624044 CR615924 AA805768 
    BQ002933 BE855908 BC022333 T16472 BE552422 BU945472 BC047029 BQ435302 
    N77138 BG503466 F11883 F03229 BI756639 BC061698 F09530 BM800721 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NUP35 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10
    SP1:                                                  -           -     -                                                         
    SP2:                                                  -           -     -           -     -                                       
    SP3:                                                  -                 -           -     -                                       
    SP4:                                                  -                 -                                                         
    SP5:                                                  -           -     -     -     -     -     -                                 


    ECgene alternative splicing isoforms for NUP35

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NUP35 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGGGAACT
    NUP35 Expression
    About this image


    NUP35 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    NUP35 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NUP35 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.180591
        Custom PCR Arrays for NUP35
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat NUP35
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUP35

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NUP35 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nup351 , 5 nucleoporin 351, 5 88.31(n)1
    93.23(a)1
      2 (48.31 cM)5
    694821  NM_027091.41  NP_081367.11 
     806172365 
    chicken
    (Gallus gallus)
    Aves NUP351 nucleoporin 35kDa 77.06(n)
    83.64(a)
      423998  XM_421854.4  XP_421854.1 
    lizard
    (Anolis carolinensis)
    Reptilia NUP356
    nucleoporin 35kDa
    80(a)
    1 ↔ 1
    GL343221.1(1865523-1881296)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC642812 hypothetical protein MGC64281 76.83(n)    BC054165.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj68d112 wufj68d11 78.67(n)   337461  BC061958.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG65401 CG6540 40.37(n)
    34.6(a)
      32851  NM_133086.3  NP_573314.1 
    worm
    (Caenorhabditis elegans)
    Secernentea npp-196
    Protein NPP-19, isoform b (npp-19) mRNA, complete ...
    20(a)
    1 ↔ 1
    II(10796586-10798479) WBGene00003805


    ENSEMBL Gene Tree for NUP35 (if available)
    TreeFam Gene Tree for NUP35 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NUP35 gene

    Find genes that share paralogs with NUP35           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for NUP35
    PGOHUM00000238699 PGOHUM00000232898


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NUP35 (see all 985)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1404059931,2
    --183987086(+) GGCATA/GAGCCA 1 -- us2k10--------
    rs76085451,2
    C,F,A,H--183987210(+) GTGCCA/GTATAT 1 -- us2k121Minor allele frequency- G:0.40NS EA NA WA CSA 2231
    rs728926561,2
    C,F--183987255(+) ATCTAT/ACACAG 1 -- us2k11Minor allele frequency- A:0.04NA 120
    rs1442649361,2
    C--183987262(+) ACAGAA/GGTCTT 1 -- us2k10--------
    rs1884892581,2
    --183987301(+) ATCCAC/TCTAAT 1 -- us2k10--------
    rs1922495591,2
    --183987379(+) TATTTG/TGTAGA 1 -- us2k10--------
    rs26751031,2
    C,F,H--183987402(+) cactaT/Actcaa 1 -- us2k16Minor allele frequency- A:0.05NS EA CSA NA 542
    rs76089631,2
    C,F,A--183987615(+) tgaatT/Gttacc 1 -- us2k1 tfbs34Minor allele frequency- G:0.38NA WA 8
    rs342679831,2
    C--183987623(+) ACCTT-/ATATGG 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs75698541,2
    C,F,A,H--183987655(+) gattaC/Ttaact 1 -- us2k1 tfbs313Minor allele frequency- T:0.34NS EA NA WA CSA 782

    HapMap Linkage Disequilibrium report for NUP35 (183982241 - 184026408 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for NUP35:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2668397CNV Deletion23128226
    esv26746CNV Loss19812545
    nsv875486CNV Loss21882294
    nsv875485CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NUP35
    DNA2.0 Custom Variant and Variant Library Synthesis for NUP35

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608140    OMIM disorders: --


    Find genes that share disorders with NUP35           About GenesLikeMe

    Genetic Association Database (GAD): NUP35
    Human Genome Epidemiology (HuGE) Navigator: NUP35 (1 document)

    Export disorders for NUP35 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NUP35 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with NUP35)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The conserved transmembrane nucleoporin NDC1 is required for nuclear pore complex assembly in vertebrate cells. (PubMed id 16600873)1, 2 Mansfeld J.... Antonin W. (Mol. Cell 2006)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    4. Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex. (PubMed id 15703211)1, 2 Hawryluk-Gara L.A.... Wozniak R.W. (Mol. Biol. Cell 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Proteomic analysis of the mammalian nuclear pore complex. (PubMed id 12196509)1, 2 Cronshaw J.M.... Matunis M.J. (J. Cell Biol. 2002)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Dimerization and direct membrane interaction of Nup53 contribute to nuclear pore complex assembly. (PubMed id 22960634)1 Vollmer B....Antonin W. (EMBO J. 2012)
    10. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PubMed id 22678362)1 Stehling O.... Lill R. (Science 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 129401 HGNC: 29797 AceView: NUP35 Ensembl:ENSG00000163002 euGenes: HUgn129401
    ECgene: NUP35 Kegg: 129401 H-InvDB: NUP35

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NUP35 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NUP35 gene:
    Search GeneIP for patents involving NUP35

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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