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Aliases for NUP35 Gene

Aliases for NUP35 Gene

  • Nucleoporin 35kDa 2 3
  • Nuclear Pore Complex Protein Nup53 3 4
  • Mitotic Phosphoprotein 44 3 4
  • MP-44 3 4
  • NUP53 3 4
  • MP44 3 4
  • NP44 3 6
  • 35 KDa Nucleoporin 4
  • Nucleoporin NUP53 3
  • Nucleoporin Nup35 4

External Ids for NUP35 Gene

Previous GeneCards Identifiers for NUP35 Gene

  • GC02P184192
  • GC02P183814
  • GC02P183697
  • GC02P183982
  • GC02P175847

Summaries for NUP35 Gene

Entrez Gene Summary for NUP35 Gene

  • This gene encodes a member of the nucleoporin family. The encoded protein contains two membrane binding regions, is localized to the nuclear rim, and is part of the nuclear pore complex. All molecules entering or leaving the nucleus either diffuse through or are actively transported by the nuclear pore complex. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 7 and 10. [provided by RefSeq, Dec 2013]

GeneCards Summary for NUP35 Gene

NUP35 (Nucleoporin 35kDa) is a Protein Coding gene. Among its related pathways are Disease and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for NUP35 Gene

  • Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs). Can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC.

Gene Wiki entry for NUP35 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP35 Gene

Genomics for NUP35 Gene

Regulatory Elements for NUP35 Gene

Genomic Location for NUP35 Gene

Start:
183,117,490 bp from pter
End:
183,161,684 bp from pter
Size:
44,195 bases
Orientation:
Plus strand

Genomic View for NUP35 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUP35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP35 Gene

Proteins for NUP35 Gene

  • Protein details for NUP35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFH5-NUP53_HUMAN
    Recommended name:
    Nucleoporin NUP53
    Protein Accession:
    Q8NFH5
    Secondary Accessions:
    • B4DP57
    • B4DYB4
    • Q4ZFZ9
    • Q53S95
    • Q8TDJ1

    Protein attributes for NUP35 Gene

    Size:
    326 amino acids
    Molecular mass:
    34774 Da
    Quaternary structure:
    • Interacts with TMEM48/NDC1. Forms a complex with NUP93, NUP155, NUP205 and lamin B; the interaction with NUP93 is direct.

    Three dimensional structures from OCA and Proteopedia for NUP35 Gene

    Alternative splice isoforms for NUP35 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUP35 Gene

Proteomics data for NUP35 Gene at MOPED

Post-translational modifications for NUP35 Gene

  • Ubiquitination at Lys269 and Lys294
  • Modification sites at PhosphoSitePlus

Other Protein References for NUP35 Gene

No data available for DME Specific Peptides for NUP35 Gene

Domains for NUP35 Gene

Protein Domains for NUP35 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8NFH5

UniProtKB/Swiss-Prot:

NUP53_HUMAN :
  • Q8NFH5
Domain:
  • Contains 1 RRM Nup35-type domain.
Family:
  • Belongs to the Nup53 family.
genes like me logo Genes that share domains with NUP35: view

No data available for Gene Families for NUP35 Gene

Function for NUP35 Gene

Molecular function for NUP35 Gene

UniProtKB/Swiss-Prot Function: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs). Can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC.

Gene Ontology (GO) - Molecular Function for NUP35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NUP35: view

Animal Model Products

CRISPR Products

miRNA for NUP35 Gene

miRTarBase miRNAs that target NUP35

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NUP35 Gene

Localization for NUP35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP35 Gene

Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein. Note=Tightly associated with the nuclear membrane and lamina.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUP35 Gene COMPARTMENTS Subcellular localization image for NUP35 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
plasma membrane 4
cytosol 2

Gene Ontology (GO) - Cellular Components for NUP35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005635 nuclear envelope TAS --
GO:0005643 nuclear pore IEA --
GO:0005654 nucleoplasm IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with NUP35: view

Pathways for NUP35 Gene

SuperPathways for NUP35 Gene

genes like me logo Genes that share pathways with NUP35: view

Pathways by source for NUP35 Gene

42 Reactome pathways for NUP35 Gene
1 KEGG pathway for NUP35 Gene

Gene Ontology (GO) - Biological Process for NUP35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0005975 carbohydrate metabolic process TAS --
GO:0007077 mitotic nuclear envelope disassembly TAS --
GO:0008645 hexose transport TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with NUP35: view

Transcripts for NUP35 Gene

Unigene Clusters for NUP35 Gene

Nucleoporin 35kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NUP35

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUP35 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10
SP1: - - -
SP2: - - - - -
SP3: - - - -
SP4: - -
SP5: - - - - - - -
SP6: -
SP7:

Relevant External Links for NUP35 Gene

GeneLoc Exon Structure for
NUP35
ECgene alternative splicing isoforms for
NUP35

Expression for NUP35 Gene

mRNA expression in normal human tissues for NUP35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUP35 Gene

SOURCE GeneReport for Unigene cluster for NUP35 Gene Hs.180591

genes like me logo Genes that share expressions with NUP35: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NUP35 Gene

Orthologs for NUP35 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUP35 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUP35 35
  • 99.8 (n)
  • 100 (a)
NUP35 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NUP35 35
  • 92.84 (n)
  • 96.63 (a)
NUP35 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUP35 35
  • 94.61 (n)
  • 98.06 (a)
NUP35 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm4353 36
  • 93 (a)
OneToMany
Nup35 35
  • 88.31 (n)
  • 93.23 (a)
Nup35 16
Nup35 36
  • 93 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia NUP35 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 84 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nup35 35
  • 89.23 (n)
  • 94.77 (a)
chicken
(Gallus gallus)
Aves NUP35 35
  • 77.06 (n)
  • 83.64 (a)
NUP35 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUP35 36
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC64281 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nup35 35
  • 74.32 (n)
  • 75.47 (a)
zebrafish
(Danio rerio)
Actinopterygii nup35 35
  • 70.43 (n)
  • 77.08 (a)
nup35 36
  • 73 (a)
OneToOne
wufj68d11 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008619 35
  • 39.96 (n)
  • 36.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6540 35
  • 40.37 (n)
  • 34.6 (a)
CG6540 36
  • 29 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea npp-19 36
  • 20 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10509 36
  • 42 (a)
OneToOne
Species with no ortholog for NUP35:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUP35 Gene

ENSEMBL:
Gene Tree for NUP35 (if available)
TreeFam:
Gene Tree for NUP35 (if available)

Paralogs for NUP35 Gene

Pseudogenes.org Pseudogenes for NUP35 Gene

genes like me logo Genes that share paralogs with NUP35: view

No data available for Paralogs for NUP35 Gene

Variants for NUP35 Gene

Sequence variations from dbSNP and Humsavar for NUP35 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs925803 -- 183,131,014(-) ACTGA(G/T)CAGGA intron-variant, utr-variant-5-prime
rs925806 -- 183,131,353(-) ACTTA(C/T)CAACT intron-variant
rs1006141 -- 183,139,834(+) gactt(C/T)gggcc intron-variant
rs1006142 -- 183,139,844(+) ctcca(G/T)aattt intron-variant
rs1110953 -- 183,119,781(-) CTTGA(C/G)CCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUP35 Gene

Variant ID Type Subtype PubMed ID
nsv875485 CNV Gain 21882294
esv2668397 CNV Deletion 23128226
esv26746 CNV Loss 19812545
nsv875486 CNV Loss 21882294

Relevant External Links for NUP35 Gene

HapMap Linkage Disequilibrium report
NUP35

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUP35 Gene

Disorders for NUP35 Gene

Relevant External Links for NUP35

Genetic Association Database (GAD)
NUP35
Human Genome Epidemiology (HuGE) Navigator
NUP35
genes like me logo Genes that share disorders with NUP35: view

No data available for UniProtKB/Swiss-Prot for NUP35 Gene

Publications for NUP35 Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex. (PMID: 15703211) Hawryluk-Gara L.A. … Wozniak R.W. (Mol. Biol. Cell 2005) 3 4
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  5. The conserved transmembrane nucleoporin NDC1 is required for nuclear pore complex assembly in vertebrate cells. (PMID: 16600873) Mansfeld J. … Antonin W. (Mol. Cell 2006) 3 4

Products for NUP35 Gene

Sources for NUP35 Gene

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