NUP35 Gene
protein-coding GIFtS: 50
GCID: GC02P183982
|
|
nucleoporin 35kDa
| |
Aliases for NUP35 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Nucleoporin 35kDa1 2 | | 35 KDa Nucleoporin2 3 | | MP441 2 3 | | MP-442 3 | | Mitotic Phosphoprotein 442 3 | | NUP532 3 | | Nuclear Pore Complex Protein Nup532 3 | | NP442 5 | | Nucleoporin Nup352 3 | | Nucleoporin NUP532 |
Export aliases for NUP35 gene to outside databasesPrevious GC identifers: GC02P184192 GC02P183814 GC02P183697 GC02P175847 |
Summaries for NUP35 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for NUP35: This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is part of thenuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are activelytransported by the NPC. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: NUP53_HUMAN, Q8NFH5Function: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to asnucleoporins (NUPs). Can play the role of both NPC structural components and of docking or interaction partners fortransiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC Gene Wiki entry for NUP35
|
Genomic Views for NUP35 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the NUP35 gene promoter: POU2F2 (Oct-2.1) Oct-B1 oct-B3 oct-B2 AML1a POU2F2 FOXL1 SRY POU2F1 POU2F1a Other transcription factors
Search SABiosciences Chromatin IP Primers for NUP35
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUP35 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q32.1 Ensembl cytogenetic band: 2q32.1 HGNC cytogenetic band: 2q32NUP35 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P183982: view genomic region
(about GC identifiers)
Start:
|
183,982,241 bp from pter |
End:
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184,026,408 bp from pter |
Size:
|
44,168 bases |
Orientation:
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plus strand |
|
Proteins for NUP35 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: NUP53_HUMAN, Q8NFH5 (See
protein sequence)Recommended Name: Nucleoporin NUP53 Size: 326 amino acids; 34774 Da
Subunit: Interacts with TMEM48/NDC1. Forms a complex with NUP93, NUP155, NUP205 and lamin B; the interaction with NUP93is direct
Subcellular location: Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein. Note=Tightlyassociated with the nuclear membrane and lamina
Secondary accessions: Q4ZFZ9 Q53S95 Q8TDJ1Explore the universe of human proteins at neXtProt for NUP35: NX_Q8NFH5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NFH5 NUP35 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_612142.2 ENSEMBL proteins: ENSP00000403819 ENSP00000412554 ENSP00000387305 ENSP00000393130 ENSP00000295119 ENSP00000364066 ENSP00000412311 ENSP00000442019 Reactome Protein details: Q8NFH5 Human Recombinant Protein Products:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
NUP35 for ontologies About GeneDecksing
NUP35 Antibody Products: Assay Products for NUP35: |
Protein
Domains / Families for NUP35 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NUP35 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NFH5ProtoNet protein and cluster: Q8NFH5 UniProtKB/Swiss-Prot: NUP53_HUMAN, Q8NFH5Similarity: Belongs to the Nup53 familySimilarity: Contains 1 RRM Nup35-type domain |
Function for NUP35 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: NUP53_HUMAN, Q8NFH5Function: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to asnucleoporins (NUPs). Can play the role of both NPC structural components and of docking or interaction partners fortransiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUP35 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUP35 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NUP35 (NM_138285) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NUP35 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUP35  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUP35 |
|
Pathways & Interactions for NUP35 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus | | | 2 | Cytokine Signaling in Immune system | | | 3 | HIV Infection | | | 4 | SLC-mediated transmembrane transport | | | 5 | Late Phase of HIV Life Cycle | |
Pathway sources See GeneCards unified pathways Show all pathways
5/23
Reactome Pathways for NUP35 (see all 23)
1
Kegg Pathway (Kegg details for NUP35):
NUP35 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NUP35
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
 5/65 Interacting proteins for NUP35 (ENSP000002951194) via UniProtKB, MINT, STRING, and/or I2D (see all 65)About this table
Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table
NUP35 for ontologies About GeneDecksing
|
Drugs & Compounds for NUP35 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for NUP35 Search CenterWatch for drugs/clinical trials and news about NUP35 / NUP53 
|
Transcripts for NUP35 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for NUP35 gene (2 alternative transcripts): NM_138285.3 NM_001008544.1 Unigene Cluster for NUP35: Nucleoporin 35kDa Hs.180591 [show with all ESTs]Unigene Representative Sequence: BC11101611 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000442895 ENST00000446612 ENST00000409798 ENST00000472844 ENST00000455063 ENST00000295119(uc010zfs.2 uc002upf.3 uc010zft.2 uc002upg.3) ENST00000497330 ENST00000374930 ENST00000479162 ENST00000452137 ENST00000541912
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUP35 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUP35 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NUP35 (NM_138285) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NUP35 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUP35  |
Additional cDNA sequence: AF411516.1 AF514993.1 AK289601.1 AK290760.1 AK298199.1 AK302350.1 BC022333.1 BC035597.1 BC047029.1 BC061698.1 BC111016.1 7 DOTS entries: DT.415692 DT.92439428 DT.92439430 DT.86858290 DT.102827351 DT.120944993 DT.95271139 24/149 AceView cDNA sequences (see all 149): F09530 BC061698 F03229 BI756639 F11883 BG503466 BE552422 N77138 BQ435302 BC047029 N59330 Z43996 BU945472 CR619859 AA805736 BC035597 BQ002933 BC022333 BE855908 T16472 AA805768 CR624044 CR615924 BI090075 GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for NUP35 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | - |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | - |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for NUP35
|
Expression for NUP35 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NUP35 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: AAGGGGAACT
About this image See NUP35 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for NUP35
SOURCE GeneReport for Unigene cluster: Hs.180591 SABiosciences Custom PCR Arrays for NUP35
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUP35 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat NUP35 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUP35 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUP35 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUP35 |
Orthologs for NUP35 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for NUP35 gene from 9/25 species (see all 25) About this table
ENSEMBL Gene Tree for NUP35 (if available) TreeFam Gene Tree for NUP35 (if available)  |
Paralogs for NUP35 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for NUP35 gene
NUP35 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for NUP35 PGOHUM00000238699 PGOHUM00000232898
|
Genomic Variants for NUP35 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 2 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for NUP35 (183982241 - 184026408 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 4 variations for NUP35 4 Indels: 78895 78894 63250 90168  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NUP35 |
|
Disorders
/ Diseases for NUP35 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NUP35 for disorders About GeneDecksing
OMIM gene information: 608140
OMIM disorders: --
1 disease for NUP35: About MalaCardshepatitis Human Genome Epidemiology (HuGE) Navigator: NUP35 (1 document) Export disorders for NUP35 gene to outside databases
|
Publications for NUP35 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NUP35 gene, integrated from 9 sources (see all 23): (articles sorted by number of sources associating them with NUP35) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The conserved transmembrane nucleoporin NDC1 is required for nuclear pore complex assembly in vertebrate cells. (PubMed id 16600873)1, 2 Mansfeld J.... Antonin W. (2006)
- Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex. (PubMed id 15703211)1, 2 Hawryluk-Gara L.A.... Wozniak R.W. (2005)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Proteomic analysis of the mammalian nuclear pore complex. (PubMed id 12196509)1, 2 Cronshaw J.M.... Matunis M.J. (2002)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
|
External Searches for NUP35 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing NUP35 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NUP35 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NUP35 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for NUP35 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NUP35 gene: Search GeneIP for patents involving NUP35
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for NUP35 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NUP35 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NUP35 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUP35 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUP35 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUP35 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUP35 |
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| | | Search Tocris compounds for NUP35 |
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 | | NUP35 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUP35 |
|  |  |  | | | ThermoFisher Antibodies for NUP35 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUP35 |
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