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Aliases for NUP35 Gene

Aliases for NUP35 Gene

  • Nucleoporin 35kDa 2 3 5
  • Nuclear Pore Complex Protein Nup53 3 4
  • Mitotic Phosphoprotein 44 3 4
  • MP-44 3 4
  • NUP53 3 4
  • MP44 3 4
  • 35 KDa Nucleoporin 4
  • Nucleoporin Nup35 4
  • NP44 3

External Ids for NUP35 Gene

Previous GeneCards Identifiers for NUP35 Gene

  • GC02P184192
  • GC02P183814
  • GC02P183697
  • GC02P183982
  • GC02P175847

Summaries for NUP35 Gene

Entrez Gene Summary for NUP35 Gene

  • This gene encodes a member of the nucleoporin family. The encoded protein contains two membrane binding regions, is localized to the nuclear rim, and is part of the nuclear pore complex. All molecules entering or leaving the nucleus either diffuse through or are actively transported by the nuclear pore complex. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 7 and 10. [provided by RefSeq, Dec 2013]

GeneCards Summary for NUP35 Gene

NUP35 (Nucleoporin 35kDa) is a Protein Coding gene. Among its related pathways are Gene Expression and Metabolism.

UniProtKB/Swiss-Prot for NUP35 Gene

  • Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs). Can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC.

Gene Wiki entry for NUP35 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP35 Gene

Genomics for NUP35 Gene

Regulatory Elements for NUP35 Gene

Genomic Location for NUP35 Gene

Chromosome:
2
Start:
183,117,490 bp from pter
End:
183,161,684 bp from pter
Size:
44,195 bases
Orientation:
Plus strand

Genomic View for NUP35 Gene

Genes around NUP35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUP35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUP35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP35 Gene

Proteins for NUP35 Gene

  • Protein details for NUP35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFH5-NUP53_HUMAN
    Recommended name:
    Nucleoporin NUP53
    Protein Accession:
    Q8NFH5
    Secondary Accessions:
    • B4DP57
    • B4DYB4
    • Q4ZFZ9
    • Q53S95
    • Q8TDJ1

    Protein attributes for NUP35 Gene

    Size:
    326 amino acids
    Molecular mass:
    34774 Da
    Quaternary structure:
    • Interacts with TMEM48/NDC1. Forms a complex with NUP93, NUP155, NUP205 and lamin B; the interaction with NUP93 is direct.

    Three dimensional structures from OCA and Proteopedia for NUP35 Gene

    Alternative splice isoforms for NUP35 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUP35 Gene

Proteomics data for NUP35 Gene at MOPED

Post-translational modifications for NUP35 Gene

  • Ubiquitination at Lys 269 and Lys 294
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cloud-Clone Corp. Antibodies for NUP35

No data available for DME Specific Peptides for NUP35 Gene

Domains & Families for NUP35 Gene

Gene Families for NUP35 Gene

Protein Domains for NUP35 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NFH5

UniProtKB/Swiss-Prot:

NUP53_HUMAN :
  • Contains 1 RRM Nup35-type domain.
  • Belongs to the Nup53 family.
Domain:
  • Contains 1 RRM Nup35-type domain.
Family:
  • Belongs to the Nup53 family.
genes like me logo Genes that share domains with NUP35: view

Function for NUP35 Gene

Molecular function for NUP35 Gene

UniProtKB/Swiss-Prot Function:
Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs). Can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC.

Gene Ontology (GO) - Molecular Function for NUP35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003697 single-stranded DNA binding IBA --
genes like me logo Genes that share ontologies with NUP35: view

Phenotypes for NUP35 Gene

genes like me logo Genes that share phenotypes with NUP35: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUP35 Gene

Localization for NUP35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP35 Gene

Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein. Note=Tightly associated with the nuclear membrane and lamina. {ECO:0000269 PubMed:15703211}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUP35 Gene COMPARTMENTS Subcellular localization image for NUP35 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
plasma membrane 5
cytosol 2

Gene Ontology (GO) - Cellular Components for NUP35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005652 nuclear lamina IEA --
GO:0031965 nuclear membrane IEA,IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with NUP35: view

Pathways & Interactions for NUP35 Gene

SuperPathways for NUP35 Gene

Superpath Contained pathways
1 Regulation of Glucokinase by Glucokinase Regulatory Protein
2 Infectious disease
.48
3 SUMOylation
4 Mitotic Prophase
5 Cell Cycle, Mitotic
.61
genes like me logo Genes that share pathways with NUP35: view

Pathways by source for NUP35 Gene

Gene Ontology (GO) - Biological Process for NUP35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0006406 mRNA export from nucleus TAS --
GO:0006409 tRNA export from nucleus TAS --
GO:0007077 mitotic nuclear envelope disassembly TAS --
GO:0008033 tRNA processing TAS --
genes like me logo Genes that share ontologies with NUP35: view

No data available for SIGNOR curated interactions for NUP35 Gene

Drugs & Compounds for NUP35 Gene

No Compound Related Data Available

Transcripts for NUP35 Gene

Unigene Clusters for NUP35 Gene

Nucleoporin 35kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUP35 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10
SP1: - - -
SP2: - - - - -
SP3: - - - -
SP4: - -
SP5: - - - - - - -
SP6: -
SP7:

Relevant External Links for NUP35 Gene

GeneLoc Exon Structure for
NUP35
ECgene alternative splicing isoforms for
NUP35

Expression for NUP35 Gene

mRNA expression in normal human tissues for NUP35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NUP35 Gene

This gene is overexpressed in Testis (10.4), Peripheral blood mononuclear cells (9.8), and Liver (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUP35 Gene



SOURCE GeneReport for Unigene cluster for NUP35 Gene Hs.180591

genes like me logo Genes that share expression patterns with NUP35: view

Protein tissue co-expression partners for NUP35 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NUP35 Gene

Orthologs for NUP35 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUP35 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NUP35 35
  • 92.84 (n)
  • 96.63 (a)
NUP35 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUP35 35
  • 94.61 (n)
  • 98.06 (a)
NUP35 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nup35 35
  • 88.31 (n)
  • 93.23 (a)
Nup35 16
Gm4353 36
  • 93 (a)
OneToMany
Nup35 36
  • 93 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia NUP35 35
  • 99.8 (n)
  • 100 (a)
NUP35 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nup35 35
  • 89.23 (n)
  • 94.77 (a)
oppossum
(Monodelphis domestica)
Mammalia NUP35 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 84 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
chicken
(Gallus gallus)
Aves NUP35 35
  • 77.06 (n)
  • 83.64 (a)
NUP35 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUP35 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nup35 35
  • 74.32 (n)
  • 75.47 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC64281 35
zebrafish
(Danio rerio)
Actinopterygii nup35 35
  • 70.43 (n)
  • 77.08 (a)
wufj68d11 35
nup35 36
  • 73 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008619 35
  • 39.96 (n)
  • 36.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6540 35
  • 40.37 (n)
  • 34.6 (a)
CG6540 36
  • 29 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea npp-19 36
  • 20 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10509 36
  • 42 (a)
OneToOne
Species with no ortholog for NUP35:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUP35 Gene

ENSEMBL:
Gene Tree for NUP35 (if available)
TreeFam:
Gene Tree for NUP35 (if available)

Paralogs for NUP35 Gene

Pseudogenes.org Pseudogenes for NUP35 Gene

genes like me logo Genes that share paralogs with NUP35: view

No data available for Paralogs for NUP35 Gene

Variants for NUP35 Gene

Sequence variations from dbSNP and Humsavar for NUP35 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs925803 -- 183,131,014(-) ACTGA(G/T)CAGGA intron-variant, utr-variant-5-prime
rs925806 -- 183,131,353(-) ACTTA(C/T)CAACT intron-variant
rs1006141 -- 183,139,834(+) gactt(C/T)gggcc intron-variant
rs1006142 -- 183,139,844(+) ctcca(G/T)aattt intron-variant
rs1110953 -- 183,119,781(-) CTTGA(C/G)CCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUP35 Gene

Variant ID Type Subtype PubMed ID
nsv875485 CNV Gain 21882294
esv2668397 CNV Deletion 23128226
esv26746 CNV Loss 19812545
nsv875486 CNV Loss 21882294

Variation tolerance for NUP35 Gene

Residual Variation Intolerance Score: 30.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUP35 Gene

HapMap Linkage Disequilibrium report
NUP35

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUP35 Gene

Disorders for NUP35 Gene

Relevant External Links for NUP35

Genetic Association Database (GAD)
NUP35
Human Genome Epidemiology (HuGE) Navigator
NUP35
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUP35

No disorders were found for NUP35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUP35 Gene

Publications for NUP35 Gene

  1. The conserved transmembrane nucleoporin NDC1 is required for nuclear pore complex assembly in vertebrate cells. (PMID: 16600873) Mansfeld J. … Antonin W. (Mol. Cell 2006) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Identifying biological pathways that underlie primordial short stature using network analysis. (PMID: 24711643) Hanson D. … Clayton P.E. (J. Mol. Endocrinol. 2014) 3
  4. Probing nuclear pore complex architecture with proximity-dependent biotinylation. (PMID: 24927568) Kim D.I. … Roux K.J. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for NUP35 Gene

Sources for NUP35 Gene

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