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Aliases for NUP214 Gene

Aliases for NUP214 Gene

  • Nucleoporin 214kDa 2 3
  • CAIN 3 4
  • CAN 3 4
  • Nuclear Pore Complex Protein Nup214 2
  • CAN Protein, Putative Oncogene 3
  • Nucleoporin 214kD (CAIN) 2
  • 214 KDa Nucleoporin 4
  • Nucleoporin Nup214 4
  • Putative Oncogene 2
  • CAN Protein 2
  • Protein CAN 4
  • KIAA0023 4
  • D9S46E 3
  • P250 3
  • N214 3

External Ids for NUP214 Gene

Previous GeneCards Identifiers for NUP214 Gene

  • GC09P125015
  • GC09P125547
  • GC09P127354
  • GC09P129277
  • GC09P131031
  • GC09P132990
  • GC09P134000
  • GC09P103491

Summaries for NUP214 Gene

Entrez Gene Summary for NUP214 Gene

  • The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome. [provided by RefSeq, Jul 2008]

GeneCards Summary for NUP214 Gene

NUP214 (Nucleoporin 214kDa) is a Protein Coding gene. Diseases associated with NUP214 include acute myeloid leukemia with t(6;9)(p23;q34) and leukemia, acute lymphoblastic. Among its related pathways are Immune System and Infectious disease. GO annotations related to this gene include transporter activity and nucleocytoplasmic transporter activity.

UniProtKB/Swiss-Prot for NUP214 Gene

  • May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex

Gene Wiki entry for NUP214 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP214 Gene

Genomics for NUP214 Gene

Regulatory Elements for NUP214 Gene

Transcription factor binding sites by QIAGEN in the NUP214 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NUP214 Gene

Chromosome:
9
Start:
131,124,959 bp from pter
End:
131,234,670 bp from pter
Size:
109,712 bases
Orientation:
Plus strand

Genomic View for NUP214 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUP214 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP214 Gene

Proteins for NUP214 Gene

  • Protein details for NUP214 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35658-NU214_HUMAN
    Recommended name:
    Nuclear pore complex protein Nup214
    Protein Accession:
    P35658
    Secondary Accessions:
    • A6NFQ0
    • Q15010
    • Q3KQZ0
    • Q5JUP7
    • Q75R47
    • Q86XD3

    Protein attributes for NUP214 Gene

    Size:
    2090 amino acids
    Molecular mass:
    213620 Da
    Quaternary structure:
    • Homodimer. Interacts with DDX19, NUP88, XPO1 and XPO5. Interacts with human herpes virus 1 (HHV-1) protein UL25; this interaction might be essential to the capsid docking onto the host nuclear pore.
    SequenceCaution:
    • Sequence=BAD07398.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NUP214 Gene

    Alternative splice isoforms for NUP214 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUP214 Gene

Proteomics data for NUP214 Gene at MOPED

Post-translational modifications for NUP214 Gene

  • Probably glycosylated as it reacts with wheat germ agglutinin (WGA)
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NUP214 Gene

Domains & Families for NUP214 Gene

Gene Families for NUP214 Gene

Protein Domains for NUP214 Gene

Graphical View of Domain Structure for InterPro Entry

P35658

UniProtKB/Swiss-Prot:

NU214_HUMAN :
  • Contains FG repeats
Domain:
  • Contains FG repeats
  • The beta-propeller contains long interblade connector loops, and mediates interaction with DDX19B
genes like me logo Genes that share domains with NUP214: view

Function for NUP214 Gene

Molecular function for NUP214 Gene

GENATLAS Biochemistry:
nucleoporin,involved in nucleocytoplasmic transport processes and cell cycle progression
UniProtKB/Swiss-Prot Function:
May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex

Gene Ontology (GO) - Molecular Function for NUP214 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity TAS 8108440
GO:0005487 nucleocytoplasmic transporter activity IEA --
GO:0005515 protein binding IPI 11545741
genes like me logo Genes that share ontologies with NUP214: view
genes like me logo Genes that share phenotypes with NUP214: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NUP214

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for NUP214 Gene

Localization for NUP214 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP214 Gene

Nucleus, nuclear pore complex. Note=Cytoplasmic filaments.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUP214 Gene COMPARTMENTS Subcellular localization image for NUP214 gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for NUP214 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005643 nuclear pore IEA --
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0005925 focal adhesion IDA --
genes like me logo Genes that share ontologies with NUP214: view

Pathways & Interactions for NUP214 Gene

SuperPathways for NUP214 Gene

Superpath Contained pathways
1 Transport of Ribonucleoproteins into the Host Nucleus
2 Infectious disease
.53
3 Cell Cycle, Mitotic
.62
4 Mitotic Prophase
5 Influenza Viral RNA Transcription and Replication
genes like me logo Genes that share pathways with NUP214: view

SIGNOR curated interactions for NUP214 Gene

Activates:

Gene Ontology (GO) - Biological Process for NUP214 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0005975 carbohydrate metabolic process TAS --
GO:0006406 mRNA export from nucleus IEA --
GO:0006606 protein import into nucleus IEA --
GO:0006611 protein export from nucleus IMP 12191473
genes like me logo Genes that share ontologies with NUP214: view

Drugs & Compounds for NUP214 Gene

(1) Additional Compounds for NUP214 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
leptomycin b
87081-35-4
genes like me logo Genes that share compounds with NUP214: view

Transcripts for NUP214 Gene

Unigene Clusters for NUP214 Gene

Nucleoporin 214kDa:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NUP214

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUP214 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^
SP1: - -
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

ExUns: 24a · 24b ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b ^ 32a · 32b · 32c ^ 33a · 33b ^ 34
SP1: - - - - -
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8: -
SP9:
SP10: -
SP11: -

Relevant External Links for NUP214 Gene

GeneLoc Exon Structure for
NUP214
ECgene alternative splicing isoforms for
NUP214

Expression for NUP214 Gene

mRNA expression in normal human tissues for NUP214 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NUP214 Gene

This gene is overexpressed in CD8 Tcells (13.0), Peripheral blood mononuclear cells (8.4), and Lymph node (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUP214 Gene



SOURCE GeneReport for Unigene cluster for NUP214 Gene Hs.654530

mRNA Expression by UniProt/SwissProt for NUP214 Gene

P35658-NU214_HUMAN
Tissue specificity: Expressed in thymus, spleen, bone marrow, kidney, brain and testis, but hardly in all other tissues or in whole embryos during development
genes like me logo Genes that share expression patterns with NUP214: view

Protein tissue co-expression partners for NUP214 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for NUP214 Gene

Orthologs for NUP214 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUP214 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NUP214 35
  • 84.7 (n)
  • 83.41 (a)
NUP214 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUP214 35
  • 85.84 (n)
  • 84.64 (a)
NUP214 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nup214 35
  • 80.97 (n)
  • 78.21 (a)
Nup214 16
Nup214 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NUP214 35
  • 98.83 (n)
  • 98.98 (a)
NUP214 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nup214 35
  • 81.01 (n)
  • 78.44 (a)
oppossum
(Monodelphis domestica)
Mammalia NUP214 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
chicken
(Gallus gallus)
Aves NUP214 35
  • 68.45 (n)
  • 66.19 (a)
NUP214 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 80 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3884 35
African clawed frog
(Xenopus laevis)
Amphibia MGC52541 35
zebrafish
(Danio rerio)
Actinopterygii nup214 36
  • 43 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Nup214 37
  • 28 (a)
Nup214 36
  • 26 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea npp-14 36
  • 20 (a)
OneToOne
Species with no ortholog for NUP214:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUP214 Gene

ENSEMBL:
Gene Tree for NUP214 (if available)
TreeFam:
Gene Tree for NUP214 (if available)

Paralogs for NUP214 Gene

genes like me logo Genes that share paralogs with NUP214: view

No data available for Paralogs for NUP214 Gene

Variants for NUP214 Gene

Sequence variations from dbSNP and Humsavar for NUP214 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs16922 -- 131,134,849(+) GGATC(C/T)GAGAA intron-variant
rs102993 -- 131,139,685(-) TTTCA(A/C)CCAGA intron-variant
rs103612 - 131,144,705(+) TGAAG(C/T)CCTCC reference, missense
rs352962 -- 131,233,020(-) TATAt(A/T)ttttt intron-variant
rs352963 -- 131,230,552(-) CCTGC(A/C/T)GTAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUP214 Gene

Variant ID Type Subtype PubMed ID
dgv2423e1 CNV Complex 17122850
nsv831737 CNV Loss 17160897
nsv831738 CNV Loss 17160897
nsv893974 CNV Loss 21882294
dgv8310n71 CNV Loss 21882294
nsv831739 CNV Loss 17160897
esv7289 CNV Gain 19470904
esv275417 CNV Gain+Loss 21479260
dgv8311n71 CNV Loss 21882294
nsv893979 CNV Loss 21882294

Variation tolerance for NUP214 Gene

Residual Variation Intolerance Score: 5.03% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.98; 59.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUP214 Gene

HapMap Linkage Disequilibrium report
NUP214
Human Gene Mutation Database (HGMD)
NUP214

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUP214 Gene

Disorders for NUP214 Gene

MalaCards: The human disease database

(5) MalaCards diseases for NUP214 Gene - From: OMIM, GeneTests, Orphanet, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
acute myeloid leukemia with t(6;9)(p23;q34)
  • aml with t(6;9)(p23;q34)
leukemia, acute lymphoblastic
  • leukemia, t-cell acute lymphocytic, somatic
leukemia, acute myeloid
  • leukemia, acute myeloid, somatic
plasma cell neoplasm
  • plasmacytic tumor
myeloid leukemia
  • myeloid leukemia, nos, without mention of remission
- elite association

UniProtKB/Swiss-Prot

NU214_HUMAN
  • Note=A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene.
  • Note=A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET.

Relevant External Links for NUP214

Genetic Association Database (GAD)
NUP214
Human Genome Epidemiology (HuGE) Navigator
NUP214
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUP214
genes like me logo Genes that share disorders with NUP214: view

No data available for Genatlas for NUP214 Gene

Publications for NUP214 Gene

  1. The human CAN protein, a putative oncogene product associated with myeloid leukemogenesis, is a nuclear pore complex protein that faces the cytoplasm. (PMID: 8108440) Kraemer D. … Radu A. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 23 67
  2. Inhibition of CRM1-mediated nuclear export of transcription factors by leukemogenic NUP98 fusion proteins. (PMID: 20233715) Takeda A. … Yaseen N.R. (J. Biol. Chem. 2010) 23 67
  3. Oxidative stress inhibits nuclear protein export by multiple mechanisms that target FG nucleoporins and Crm1. (PMID: 19828735) Crampton N. … Stochaj U. (Mol. Biol. Cell 2009) 23 67
  4. Cell-cycle regulation and dynamics of cytoplasmic compartments containing the promyelocytic leukemia protein and nucleoporins. (PMID: 19339552) Jul-Larsen A. … e S.O. (J. Cell. Sci. 2009) 23 67
  5. Structural and functional analysis of the interaction between the nucleoporin Nup214 and the DEAD-box helicase Ddx19. (PMID: 19208808) Napetschnig J. … Hoelz A. (Proc. Natl. Acad. Sci. U.S.A. 2009) 23 67

Products for NUP214 Gene

Sources for NUP214 Gene

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