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NUP214 Gene

protein-coding GIFtS: 62

GC09P132990

nucleoporin 214kDa
(Previous name: nucleoporin 214kD (CAIN) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CAIN ^¹, ², ³, ⁵
CAN ^¹, ², ³, ⁵
D9S46E ^¹, ², ⁵
KIAA0023 ^³
MGC104525 ^²
N214 ^¹, ²
OTTHUMP00000064563 ^²
p250 ^²

Descriptions
214 kDa nucleoporin ^³
CAN protein, putative oncogene ^²
Nucleoporin Nup214 ^³
Protein CAN ^³
nuclear pore complex protein Nup214 ^²
nucleoporin 214kD (CAIN) ^¹, ²
nucleoporin 214kDa ^²

External Ids
HGNC: 8064¹
Entrez Gene: 8021²
UniProtKB: P35658³
Ensembl: ENSG00000126883⁷

Search outside databases for aliases for NUP214 gene

Previous GC identifers: GC09P125015 GC09P125547 GC09P127354 GC09P129277 GC09P131031

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for NUP214:

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a

gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm.

Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is

a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized

to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle

progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene

with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia

and myelodysplastic syndrome. [provided by RefSeq]

UniProtKB/Swiss-Prot: NU214_HUMAN, P35658

Function: May serve as a docking site in the receptor-mediated import of substrates across the

nuclear pore complex

Gene Wiki entry for NUP214

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the NUP214 gene

Entrez Gene cytogenetic band: 9q34.1 Ensembl cytogenetic band: 9q34.13 HGNC cytogenetic band: 9q34

NUP214 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P132990: (about GC identifiers)

Start:	132,990,802 bp from pter
End:	133,098,912 bp from pter
Size:	108,111 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000009.10 NT_035014.4

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: NU214_HUMAN, P35658 (See protein sequence)

Recommended Name: Nuclear pore complex protein Nup214

Size: 2090 amino acids; 213620 Da

Subunit: Homodimer. Interacts with DDX19, NUP88, XPO1 and XPO5

Subcellular location: Nucleus, nuclear pore complex. Note=Cytoplasmic filaments

PDB structure from and Proteopedia :

2OIT (3D)

3FHC (3D)

Secondary accessions: A6NFQ0 Q15010 Q3KQZ0 Q5JUP7 Q75R47 Q86XD3

Alternative splicing: 5 isoforms: P35658-1 P35658-2 P35658-3 P35658-4 P35658-5

Post-translational modifications:

Probably glycosylated as it reacts with wheat germ agglutinin (WGA)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_005076.3

ENSEMBL proteins:

ENSP00000352400 ENSP00000346167

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (NUP214)
	Human Recombinant Proteins from Abnova (NUP214)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005643	nuclear pore	TAS	8108440
GO:0005829	cytosol	EXP	12228227

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Antibodies for NUP214:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for NUP214
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (NUP214), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (NUP214)
	Novus Biologicals Antibodies for NUP214

Assays for NUP214:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P35658

ProtoNet protein and cluster: P35658

UniProtKB/Swiss-Prot: NU214_HUMAN, P35658

Domain: Contains FG repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NUP214)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NUP214)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005085

Applied Biosystems Silencer® siRNAs for NUP214

Sigma-Aldrich siRNA for NUP214

Sigma-Aldrich shRNA for NUP214

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005085
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005085
untagged cDNA clones in CMV expression vector (see all 2): AJ420413

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005085

UniProtKB/Swiss-Prot: NU214_HUMAN, P35658

Function: May serve as a docking site in the receptor-mediated import of substrates across the

nuclear pore complex

Genatlas biochemistry entry for NUP214:

nucleoporin,involved in nucleocytoplasmic transport processes and cell cycle progression

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Nup214):

cellular

embryogenesis

lethality-prenatal/perinatal

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005215	transporter activity	TAS	8108440
GO:0005515	protein binding	IPI	11545741

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for NUP214

5/90 Interacting proteins for NUP214 (ENSP00000346167³ P35658²) via UniProtKB, MINT, and/or STRING (see all 90 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NUP107	P57740²	STRING (score=.994) MINT-4301750
NUP160	Q12769²	STRING (score=.981) MINT-4301750
NXF1	Q9UBU9²	STRING (score=.987) MINT-15076
RANBP2	P49792²	STRING (score=.984) MINT-4301750
AHCTF1	Q8WYP5²	MINT-4301750

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006611	protein export from nucleus	IMP	12191473
GO:0015031	protein transport	IEA	--
GO:0051028	mRNA transport	IEA	--
GO:0065002	intracellular protein transmembrane transport	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for NUP214

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NUP214)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NUP214)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005085

Sigma-Aldrich siRNA for NUP214

Sigma-Aldrich shRNA for NUP214

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005085

REFSEQ mRNAs for NUP214 gene:

NM_005085.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005085

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005085
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005085
                                 untagged cDNA clones in CMV expression vector (see all 2): AJ420413

Additional cDNA sequence:

AB159230.1 AJ420413.1 AK302676.1 AK303016.1 AK307573.1 AK310406.1 AK310476.1 AK310515.1

AK316417.1 AK316435.1 AL832609.2 BC012500.1 BC045620.1 BC105998.1 BX537986.1 D14689.1

X64228.1

23 DOTS entries:

DT.453259 DT.99946775 DT.91802533 DT.40244489 DT.92068544 DT.97819744 DT.92460700 DT.75189159

DT.121159449 DT.100798030 DT.95121236 DT.100798031 DT.121159432 DT.121159477 DT.75172818 DT.92460671

DT.92460693 DT.92460701 DT.95117258 DT.95121234 DT.97845015 DT.92460689 DT.95178225

24/335 AceView cDNA sequences (see all 335 ):

AI203438 BQ212823 BQ051602 BU187774 BU539474 AL040843 BM455135 BM560722

AU125828 BQ637014 BU164616 BF724988 AA286804 CB152346 BQ188124 AL699371

CB162015 AU100267 T12639 BM545068 BX495633 AI674135 AU127630 BU737134

highest scoring ESTs for NUP214:

AL040843 AA004416 AA135786 AA193606 AA469302 AA516455 AA583028 AA921758 AI025524 AI026661

Unigene Cluster for NUP214:

Nucleoporin 214kDa

Hs.654530 [show with all ESTs]

Unigene Representative Sequence: BC105998

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for NUP214 (see all 11 )

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	·	5c	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20a	·	20b	^	21	^	22	^	23	^
SP1:																																											-		-
SP2:
SP3:
SP4:																																																	-
SP5:

ExUns:	24a	·	24b	^	25	^	26a	·	26b	^	27	^	28	^	29	^	30	^	31a	·	31b	^	32a	·	32b	·	32c	^	33a	·	33b	^	34
SP1:													-		-				-				-						-
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for NUP214

2 Ensembl transcripts including schematic representations:

ENST00000359428 ENST00000354226

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

NUP214 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for NUP214

¹ / ² / ³

9 probe-sets matching NUP214 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
54602_at²^{, 3}	U95-B	1	1.00	1.00	0.73	1.02	AL040843	1.00	1.00	1.00	1
40769_r_at²^{, 3}	U95-A	1	1.00	1.00	0.85	0.75	D14689	0.80	0.88	0.84	1
40768_s_at²^{, 3}	U95-A	2	1.00	0.97	0.93	1.24	X64228	0.80	0.88	0.84	1
202155_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005085	0.60	1.00	0.82	1
228902_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AA516455	0.80	1.00	0.91	1
211261_at²^{, 3}	U133-A	1	1.00	1.00	--	--	D14689	0.80	0.88	0.84	1
202155_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
228902_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211261_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks NUP214 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTGGGTTTTC

SOURCE GeneReport for Unigene cluster: Hs.654530
Expression variation in blood from EXPOLDB for NUP214
UniProtKB/Swiss-Prot: NU214_HUMAN, P35658
Tissue specificity: Expressed in thymus, spleen, bone marrow, kidney, brain and testis, but hardly
in all other tissues or in whole embryos during development

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for NUP214 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	NUP214¹	--	nucleoporin 214kDa	85.41(n) 87.02(a)	608534 XM_845587.1 XP_850680.1
chimpanzee (Pan troglodytes)	NUP214¹	--	nucleoporin 214kDa	99.33(n) 99.62(a)	464807 XM_001166820.1 XP_001166820.1
cow (Bos taurus)	NUP214¹	--	nucleoporin 214kDa	84.5(n) 83.1(a)	784219 XM_001252592.1 XP_001252593.1
rat (Rattus norvegicus)	Nup214¹	--	nucleoporin 214	81.44(n) 79.03(a)	296634 XM_238325.4 XP_238325.4
mouse (Mus musculus)	Nup214^{1, 5}	2 (21.30 cM)⁵	nucleoporin 214^{1, 5}	81.4(n)¹ 78.75(a)¹	227720¹ NM_172268.2¹ NP_758472.2¹ AK040284⁵ AK122189⁵ (see all 12)

About this table Species with no ortholog for NUP214

ENSEMBL Gene Tree for NUP214

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for NUP214 gene

NUP153²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/476 NCBI SNPs in NUP214 are shown (see all 476 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 139)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs103612^1,2	A,C,F,H	133009913(+)	`TGAAGT/CCCTCC`	1	S/P	mis¹ trp³		10		MN EU EA WA NA	804
	rs10122056^1,2	A,F,H	133099144(+)	`GAGGCT/CGAAAC`	1	--	ng3¹ ese³		4		EU EA WA	418
--	rs11244296^1,2	C,H	132989971(+)	`GCTGAG/AACTAC`	1	--	ng5¹		4		EU EA WA	418
	rs1064428^1,2	C,H	132994617(+)	`TATTGC/ATGTCC`	1	D/A	mis¹		8		EU EA WA	812
--	rs9328549^1,2	A,C	132990639(+)	`CCAGGA/GCCATC`	1	--	ng5¹ tfbs³		0	--	--	--	--
--	rs353506^1,2	A	132989348(-)	`tatacA/Gggagg`	1	--	ng5¹		0	--	--	--	--
--	rs3215836^1,2	C	132990589(-)	`TGTTA-/AGTCTC`	1	--	ng5¹		0	--	--	--	--
	rs12002428^1,2	H	133001164(+)	`TGGCAG/ACATCT`	1	T/A	mis¹ ese³		4		EU EA WA	418
--	rs2767417^1,2	A	132989210(+)	`tatatA/Gtatat`	1	--	ng5¹ tfbs³		0	--	--	--	--
--	rs12683223^1,2	A	132990903(+)	`ACTGAA/GGGCGG`	1	--	ut5¹ ese³		0	--	--	--	--

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HapMap Linkage Disequilibrium images for NUP214 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 114350

UniProtKB/Swiss-Prot: NU214_HUMAN, P35658

A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia

(AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It

results in the formation of a DEK-CAN fusion gene

A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated

leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET

Defects in NUP214 may be a cause of breast cancer

2 Novoseek disease relationships for NUP214 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
t-all	60.66	1	15361874 (1)
immunodeficiency	24.53	1	9847314 (1)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/74 PubMed articles for NUP214 gene (see all 74 ):

The human CAN protein, a putative oncogene product associated with myeloid leukemogenesis, is a nuclear pore complex protein that faces the cytoplasm. (PubMed id 8108440)^{1, 2, 3, 4} Kraemer D.... Radu A. (1994)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
Exportin-5, a novel karyopherin, mediates nuclear export of double- stranded RNA binding proteins. (PubMed id 11777942)^{3, 4} Brownawell A.M. and Macara I.G. (2002)
The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and the novel nuclear pore component Nup88. (PubMed id 9049309)^{3, 4} Fornerod M.... Grosveld G. (1997)
Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)^{3, 4} Nomura N....Tabata S. (1994)
The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA. (PubMed id 1549122)^{3, 4} Von Lindern M.... Grosveld G. (1992)
The (6;9) chromosome translocation, associated with a specific subtype of acute nonlymphocytic leukemia, leads to aberrant transcription of a target gene on 9q34. (PubMed id 2370860)^{2, 3} von Lindern M....Grosveld G. (1990)
Nucleoporins nup98 and nup214 participate in nuclear export of human immunodeficiency virus type 1 Rev. (PubMed id 9847314)^{1, 3} Zolotukhin A.S. and Felber B.K. (1999)
Nup214 is required for CRM1-dependent nuclear protein export in vivo. (PubMed id 16943420)^{1, 3} Hutten S. and Kehlenbach R.H. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 8021	HGNC: 8064	AceView: NUP214	Ensembl:ENSG00000126883	euGenes: HUgn8021
ECgene: NUP214	H-InvDB: NUP214

(According to HUGE)
About This Section

HUGE: KIAA0023

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for NUP214	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for NUP214
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for NUP214:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for NUP214-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for NUP214		Antibodies for NUP214
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for NUP214		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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NUP214 Gene at Home site.
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NUP214 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for NUP214

Summaries
for NUP214

Genomic Location
for NUP214

Proteins
for NUP214

Protein Domains/
Families
for NUP214

Gene Function
for NUP214

Pathways & Interactions
for NUP214

Drugs & Compounds
for NUP214

Transcripts
for NUP214

Expression
for NUP214

Orthologs
for NUP214

Paralogs
for NUP214

SNPs/Variants
for NUP214

Disorders & Mutations
for NUP214

Medical News
for NUP214

Publications
for NUP214

Search for NUP214

Genome Databases showing NUP214

Other Databases showing NUP214

Specialized Databases showing NUP214

Licensable Technologies
for NUP214

Services
for NUP214

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

NUP214 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor NUP214

Summariesfor NUP214

Genomic Locationfor NUP214

Proteinsfor NUP214

Protein Domains/Familiesfor NUP214

Gene Functionfor NUP214

Pathways & Interactionsfor NUP214

Drugs & Compoundsfor NUP214

Transcriptsfor NUP214

Expression for NUP214

Orthologsfor NUP214

Paralogsfor NUP214

SNPs/Variantsfor NUP214

Disorders & Mutationsfor NUP214

Medical Newsfor NUP214

Publicationsfor NUP214

Search for NUP214

Genome Databases showing NUP214

Other Databases showing NUP214

Specialized Databases showing NUP214

Licensable Technologiesfor NUP214

Servicesfor NUP214

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for NUP214

Summaries
for NUP214

Genomic Location
for NUP214

Proteins
for NUP214

Protein Domains/
Families
for NUP214

Gene Function
for NUP214

Pathways & Interactions
for NUP214

Drugs & Compounds
for NUP214

Transcripts
for NUP214

Expression
for NUP214

Orthologs
for NUP214

Paralogs
for NUP214

SNPs/Variants
for NUP214

Disorders & Mutations
for NUP214

Medical News
for NUP214

Publications
for NUP214

Licensable Technologies
for NUP214

Services
for NUP214