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Aliases for NUP214 Gene

Aliases for NUP214 Gene

  • Nucleoporin 214kDa 2 3 5
  • CAIN 3 4
  • CAN 3 4
  • Nuclear Pore Complex Protein Nup214 2
  • CAN Protein, Putative Oncogene 3
  • Nucleoporin 214kD (CAIN) 2
  • 214 KDa Nucleoporin 4
  • Nucleoporin Nup214 4
  • Putative Oncogene 2
  • CAN Protein 2
  • Protein CAN 4
  • KIAA0023 4

External Ids for NUP214 Gene

Previous GeneCards Identifiers for NUP214 Gene

  • GC09P125015
  • GC09P125547
  • GC09P127354
  • GC09P129277
  • GC09P131031
  • GC09P132990
  • GC09P134000
  • GC09P103491

Summaries for NUP214 Gene

Entrez Gene Summary for NUP214 Gene

  • The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

GeneCards Summary for NUP214 Gene

NUP214 (Nucleoporin 214kDa) is a Protein Coding gene. Diseases associated with NUP214 include Acute Myeloid Leukemia With T(6;9)(P23;Q34) and Leukemia, Acute Lymphoblastic. Among its related pathways are Cellular response to heat stress and Glycosaminoglycan metabolism. GO annotations related to this gene include transporter activity and nucleocytoplasmic transporter activity.

UniProtKB/Swiss-Prot for NUP214 Gene

  • May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.

Gene Wiki entry for NUP214 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP214 Gene

Genomics for NUP214 Gene

Regulatory Elements for NUP214 Gene

Enhancers for NUP214 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NUP214 on UCSC Golden Path with GeneCards custom track

Promoters for NUP214 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NUP214 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the NUP214 gene promoter:

Genomic Location for NUP214 Gene

131,124,959 bp from pter
131,234,670 bp from pter
109,712 bases
Plus strand

Genomic View for NUP214 Gene

Genes around NUP214 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUP214 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUP214 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP214 Gene

Proteins for NUP214 Gene

  • Protein details for NUP214 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nuclear pore complex protein Nup214
    Protein Accession:
    Secondary Accessions:
    • A6NFQ0
    • Q15010
    • Q3KQZ0
    • Q5JUP7
    • Q75R47
    • Q86XD3

    Protein attributes for NUP214 Gene

    2090 amino acids
    Molecular mass:
    213620 Da
    Quaternary structure:
    • Homodimer. Interacts with DDX19, NUP88, XPO1 and XPO5. Interacts with human herpes virus 1 (HHV-1) protein UL25; this interaction might be essential to the capsid docking onto the host nuclear pore.
    • Sequence=BAD07398.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NUP214 Gene

    Alternative splice isoforms for NUP214 Gene


neXtProt entry for NUP214 Gene

Proteomics data for NUP214 Gene at MOPED

Post-translational modifications for NUP214 Gene

  • Probably glycosylated as it reacts with wheat germ agglutinin (WGA).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NUP214 Gene

Domains & Families for NUP214 Gene

Gene Families for NUP214 Gene

Protein Domains for NUP214 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains FG repeats.
  • Contains FG repeats.
  • The beta-propeller contains long interblade connector loops, and mediates interaction with DDX19B.
genes like me logo Genes that share domains with NUP214: view

Function for NUP214 Gene

Molecular function for NUP214 Gene

GENATLAS Biochemistry:
nucleoporin,involved in nucleocytoplasmic transport processes and cell cycle progression
UniProtKB/Swiss-Prot Function:
May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.

Gene Ontology (GO) - Molecular Function for NUP214 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 11545741
genes like me logo Genes that share ontologies with NUP214: view
genes like me logo Genes that share phenotypes with NUP214: view

Human Phenotype Ontology for NUP214 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for NUP214 Gene

MGI Knock Outs for NUP214:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for NUP214 Gene

Localization for NUP214 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP214 Gene

Nucleus, nuclear pore complex. Note=Cytoplasmic filaments.

Subcellular locations from

Jensen Localization Image for NUP214 Gene COMPARTMENTS Subcellular localization image for NUP214 gene
Compartment Confidence
cytosol 5
nucleus 5
plasma membrane 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for NUP214 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005643 nuclear pore IEA --
genes like me logo Genes that share ontologies with NUP214: view

Pathways & Interactions for NUP214 Gene

SuperPathways for NUP214 Gene

Superpath Contained pathways
1 Regulation of Glucokinase by Glucokinase Regulatory Protein
2 Infectious disease
3 Cell Cycle, Mitotic
4 Mitotic Prophase
5 Influenza Viral RNA Transcription and Replication
genes like me logo Genes that share pathways with NUP214: view

SIGNOR curated interactions for NUP214 Gene


Gene Ontology (GO) - Biological Process for NUP214 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006606 protein import into nucleus IEA --
GO:0006611 protein export from nucleus IMP 12191473
GO:0007077 mitotic nuclear envelope disassembly TAS --
GO:0008033 tRNA processing TAS --
genes like me logo Genes that share ontologies with NUP214: view

Drugs & Compounds for NUP214 Gene

(1) Additional Compounds for NUP214 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NUP214: view

Transcripts for NUP214 Gene

Unigene Clusters for NUP214 Gene

Nucleoporin 214kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUP214 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^
SP1: - -
SP4: -

ExUns: 24a · 24b ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b ^ 32a · 32b · 32c ^ 33a · 33b ^ 34
SP1: - - - - -
SP6: -
SP8: -
SP10: -
SP11: -

Relevant External Links for NUP214 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NUP214 Gene

mRNA expression in normal human tissues for NUP214 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NUP214 Gene

This gene is overexpressed in CD8 Tcells (13.0), Peripheral blood mononuclear cells (8.4), and Lymph node (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUP214 Gene

SOURCE GeneReport for Unigene cluster for NUP214 Gene Hs.654530

mRNA Expression by UniProt/SwissProt for NUP214 Gene

Tissue specificity: Expressed in thymus, spleen, bone marrow, kidney, brain and testis, but hardly in all other tissues or in whole embryos during development.
genes like me logo Genes that share expression patterns with NUP214: view

Protein tissue co-expression partners for NUP214 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for NUP214 Gene

Orthologs for NUP214 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUP214 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NUP214 35
  • 84.7 (n)
  • 83.41 (a)
NUP214 36
  • 83 (a)
(Canis familiaris)
Mammalia NUP214 35
  • 85.84 (n)
  • 84.64 (a)
NUP214 36
  • 85 (a)
(Mus musculus)
Mammalia Nup214 35
  • 80.97 (n)
  • 78.21 (a)
Nup214 16
Nup214 36
  • 77 (a)
(Pan troglodytes)
Mammalia NUP214 35
  • 98.83 (n)
  • 98.98 (a)
NUP214 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Nup214 35
  • 81.01 (n)
  • 78.44 (a)
(Monodelphis domestica)
Mammalia NUP214 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
-- 36
  • 81 (a)
(Gallus gallus)
Aves NUP214 35
  • 68.45 (n)
  • 66.19 (a)
NUP214 36
  • 63 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 80 (a)
-- 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3884 35
African clawed frog
(Xenopus laevis)
Amphibia MGC52541 35
(Danio rerio)
Actinopterygii nup214 36
  • 43 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nup214 37
  • 28 (a)
Nup214 36
  • 26 (a)
(Caenorhabditis elegans)
Secernentea npp-14 36
  • 20 (a)
Species with no ortholog for NUP214:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUP214 Gene

Gene Tree for NUP214 (if available)
Gene Tree for NUP214 (if available)

Paralogs for NUP214 Gene

genes like me logo Genes that share paralogs with NUP214: view

No data available for Paralogs for NUP214 Gene

Variants for NUP214 Gene

Sequence variations from dbSNP and Humsavar for NUP214 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_035856 A breast cancer sample
VAR_035857 A breast cancer sample
VAR_035858 A breast cancer sample
rs103612 - 131,144,705(+) TGAAG(C/T)CCTCC reference, missense
rs28594669 - 131,198,269(+) GCCTG(C/G)GCAGA downstream-variant-500B, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NUP214 Gene

Variant ID Type Subtype PubMed ID
dgv2423e1 CNV Complex 17122850
nsv831737 CNV Loss 17160897
nsv831738 CNV Loss 17160897
nsv893974 CNV Loss 21882294
dgv8310n71 CNV Loss 21882294
nsv831739 CNV Loss 17160897
esv7289 CNV Gain 19470904
esv275417 CNV Gain+Loss 21479260
dgv8311n71 CNV Loss 21882294
nsv893979 CNV Loss 21882294

Variation tolerance for NUP214 Gene

Residual Variation Intolerance Score: 5.03% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.98; 59.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUP214 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUP214 Gene

Disorders for NUP214 Gene

MalaCards: The human disease database

(5) MalaCards diseases for NUP214 Gene - From: OMIM, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
acute myeloid leukemia with t(6;9)(p23;q34)
  • aml with t(6;9)(p23;q34)
leukemia, acute lymphoblastic
  • leukemia, t-cell acute lymphocytic, somatic
leukemia, acute myeloid
  • leukemia, acute myeloid, somatic
myeloid leukemia
  • leukemia myelogenous
plasma cell neoplasm
  • multiple myeloma
- elite association - COSMIC cancer census association via MalaCards


  • Note=A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene. {ECO:0000269 PubMed:1549122}.
  • Note=A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET. {ECO:0000269 PubMed:1630450}.

Relevant External Links for NUP214

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NUP214: view

No data available for Genatlas for NUP214 Gene

Publications for NUP214 Gene

  1. The human CAN protein, a putative oncogene product associated with myeloid leukemogenesis, is a nuclear pore complex protein that faces the cytoplasm. (PMID: 8108440) Kraemer D. … Radu A. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4 23 67
  2. Oncogenic nucleoporin CAN/Nup214 interacts with vitamin D receptor and modulates its function. (PMID: 19229862) Miyauchi Y. … Michigami T. (J. Cell. Biochem. 2009) 3 23
  3. Oxidative stress inhibits nuclear protein export by multiple mechanisms that target FG nucleoporins and Crm1. (PMID: 19828735) Crampton N. … Stochaj U. (Mol. Biol. Cell 2009) 3 23
  4. The N-terminal domain of the mammalian nucleoporin p62 interacts with other nucleoporins of the FXFG family during interphase. (PMID: 16730000) Stochaj U. … Matusiewicz N. (Exp. Cell Res. 2006) 3 23
  5. Nup214 is required for CRM1-dependent nuclear protein export in vivo. (PMID: 16943420) Hutten S. … Kehlenbach R.H. (Mol. Cell. Biol. 2006) 3 23

Products for NUP214 Gene

Sources for NUP214 Gene