NUP214 Gene
protein-coding GIFtS: 62
GCID: GC09P134000
|
|
nucleoporin 214kDa(Previous name: nucleoporin 214kD (CAIN) )
| |
Aliases
for NUP214 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nucleoporin 214kDa1 2 | | 214 KDa Nucleoporin2 3 | | CAIN1 2 3 5 | | CAN Protein, Putative Oncogene2 | | CAN1 2 3 5 | | Nuclear Pore Complex Protein Nup2142 | | D9S46E1 2 5 | | P2501 | | N2141 2 | | KIAA00233 | | Nucleoporin 214kD (CAIN)1 2 | | Protein CAN3 | | Nucleoporin Nup2142 3 | | |
Export aliases for NUP214 gene to outside databasesPrevious GC identifers: GC09P125015 GC09P125547 GC09P127354 GC09P129277 GC09P131031 GC09P132990 GC09P103491 |
Summaries
for NUP214 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NUP214:
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway thatregulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components ofthe nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. Theprotein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required forproper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene withthe DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplasticsyndrome. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: NU214_HUMAN, P35658Function: May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex
Gene Wiki entry for NUP214
|
Genomic Views
for NUP214 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_035014.4
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NUP214 gene promoter:
AML1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for NUP214
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUP214 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.1 Ensembl cytogenetic band: 9q34.13 HGNC cytogenetic band: 9q34NUP214 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P134000: view genomic region
(about GC identifiers)
Start:
|
134,000,948 bp from pter |
End:
|
134,110,057 bp from pter |
Size:
|
109,110 bases |
Orientation:
|
plus strand |
|
Proteins
for NUP214 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NU214_HUMAN, P35658 (See
protein sequence)Recommended Name: Nuclear pore complex protein Nup214 Size: 2090 amino acids; 213620 Da
Subunit: Homodimer. Interacts with DDX19, NUP88, XPO1 and XPO5. Interacts with human herpes virus 1 (HHV-1) proteinUL25; this interaction might be essential to the capsid docking onto the host nuclear pore
Subcellular location: Nucleus, nuclear pore complex. Note=Cytoplasmic filaments
Sequence caution: Sequence=BAD07398.1; Type=Erroneous initiation;
4 PDB 3D structures from  and Proteopedia  for NUP214:2OIT (3D)
3FHC (3D)
3FMO (3D)
3FMP (3D)
Secondary accessions: A6NFQ0 Q15010 Q3KQZ0 Q5JUP7 Q75R47 Q86XD3Alternative splicing: 5 isoforms: P35658-1 P35658-2 P35658-3 P35658-4 P35658-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for NUP214: NX_P35658
Post-translational modifications:
Probably glycosylated as it reacts with wheat germ agglutinin (WGA)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P35658
NUP214 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005076.3
ENSEMBL proteins: ENSP00000352400 ENSP00000396576 ENSP00000435874 ENSP00000434223 ENSP00000437139 ENSP00000416934 ENSP00000436793 ENSP00000435364 ENSP00000435583 ENSP00000433606 ENSP00000433654 ENSP00000405014 Reactome Protein details: P35658
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
NUP214 for ontologies About GeneDecksing
NUP214 Antibody Products:
Assay Products for NUP214: |
Protein
Domains /
Families
for NUP214 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NUP214 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P35658ProtoNet protein and cluster: P35658 UniProtKB/Swiss-Prot: NU214_HUMAN, P35658Domain: Contains FG repeatsDomain: The beta-propeller contains long interblade connector loops, and mediates interaction with DDX19B |
Function
for NUP214 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NU214_HUMAN, P35658Function: May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex Genatlas biochemistry entry for NUP214:nucleoporin,involved in nucleocytoplasmic transport processes and cell cycle progression
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUP214 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUP214
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NUP214 (NM_005085) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NUP214 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUP214 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUP214 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
NUP214 for ontologies About GeneDecksing
6 GenomeRNAi human phenotypes for NUP214:
Animal Models:
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Nup214):
NUP214 for phenotypes About GeneDecksing
|
Pathways & Interactions
for NUP214 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/18 super-pathways (see all 18) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus | | | 2 | Cytokine Signaling in Immune system | | | 3 | HIV Infection | | | 4 | Stabilization of mRNA by HuR | | | 5 | Metabolism of mRNA | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4  BioSystems Pathways for NUP214
5/29 
Reactome Pathways for NUP214 (see all 29)
1 
Kegg Pathway (Kegg details for NUP214):
NUP214 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NUP214
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/103 Interacting proteins for NUP214 (P356582, 3 ENSP000003524004) via UniProtKB, MINT, STRING, and/or I2D (see all 103)About this table
Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table
NUP214 for ontologies About GeneDecksing
|
Drugs & Compounds
for NUP214 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
NUP214 for compounds About GeneDecksing
 Browse Tocris compounds for NUP214
1 Novoseek chemical compound relationship for NUP214 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| leptomycin b |
70.5 |
1 |
16484227 (1) |
Search CenterWatch for drugs/clinical trials and news about NUP214 / NU214
|
Transcripts
for NUP214 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NUP214 gene: NM_005085.2 Unigene Cluster for NUP214: Nucleoporin 214kDa Hs.654530 [show with all ESTs]Unigene Representative Sequence: BC10599818/27 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27): ENST00000359428(uc004cag.3) ENST00000411637(uc004cah.3) ENST00000531584
ENST00000526412 ENST00000525561 ENST00000530843 ENST00000530863 ENST00000525980
ENST00000530630 ENST00000489260 ENST00000526346 ENST00000531929 ENST00000524578
ENST00000453861(uc010mzi.1 uc010mzg.3) ENST00000470765 ENST00000483497(uc011mcf.1 uc010mzh.1 uc011mcg.2)
ENST00000465486 ENST00000531600
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUP214 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUP214
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NUP214 (NM_005085) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NUP214 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUP214 |
Additional cDNA sequence: AB159230.1 AJ420413.1 AK302676.1 AK303016.1 AK307573.1 AK310406.1 AK310476.1 AK310515.1 AK316417.1 AK316435.1 AL832609.2 BC012500.1 BC045620.1 BC105998.1 BX537986.1 D14689.1 X64228.1 24 DOTS entries: DT.453259 DT.99946775 DT.91802533 DT.97819744 DT.40244489 DT.92460700 DT.92068544 DT.121159449 DT.75189159 DT.100798030 DT.95121236 DT.100798031 DT.121159432 DT.121159477 DT.75172818 DT.92460671 DT.92460693 DT.92460701 DT.95117258 DT.97845015 DT.86855004 DT.92460689 DT.95121234 DT.95178225 24/335 AceView cDNA sequences (see all 335): T12639 AI214628 BG818699 CA311014 BU187774 AU131389 AA699355 CK301173 AB159230 BQ637332 BM697856 NM_005085 T12557 BM560722 AL040843 BX112388 AI203438 BQ681604 AA286804 AU100267 D12142 T12558 BX495633 AI636198
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for NUP214 (see all 11) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | ^ | 21 | ^ | 22 | ^ | 23 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 24a | · | 24b | ^ | 25 | ^ | 26a | · | 26b | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31a | · | 31b | ^ | 32a | · | 32b | · | 32c | ^ | 33a | · | 33b | ^ | 34 |
|---|
|
| SP1: | | | | | | | | | | | | | - | | - | | | | - | | | | - | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NUP214
|
Expression
for NUP214 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NUP214 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGGGTTTTC
About this image
See NUP214 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NUP214
SOURCE GeneReport for Unigene cluster: Hs.654530
UniProtKB/Swiss-Prot: NU214_HUMAN, P35658Tissue specificity: Expressed in thymus, spleen, bone marrow, kidney, brain and testis, but hardly in all other tissuesor in whole embryos during development
SABiosciences Custom PCR Arrays for NUP214
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUP214
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NUP214 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUP214 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUP214 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUP214 |
Orthologs
for NUP214 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for NUP214 gene from 7/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
NUP2141 |
nucleoporin 214kDa |
68.63(n)
66.42(a) |
|
427760 XM_425333.3 XP_425333.3 |
African clawed frog
(Xenopus laevis) |
Amphibia |
MGC525412 |
similar to nucleoporin 214kDa |
74.17(n) |
|
AJ243889.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
570883232 |
-- |
72.56(n) |
|
57088323 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Nup2141 , 3 |
Nucleoporin 2141 |
28(a)3
42.93(n)1
32.55(a)1 |
|
59B63
460911 NM_143782.21 NP_652039.21 |
worm
(Caenorhabditis elegans) |
Secernentea |
npp-141 |
Protein NPP-14 |
40.7(n)
27.91(a) |
|
172813 NM_060167.5 NP_492568.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
NUP966 |
suppressor of auxin resistance 3 |
4(a) |
1 → many |
1(30324008-30328769) |
rice
(Oryza sativa) |
Liliopsida |
-- |
OsNucAP1 - Putative Nucleoporin Autopeptidase homo... |
4(a) |
1 → many |
3(3858381-3863721) |
ENSEMBL Gene Tree for NUP214 (if available)
TreeFam Gene Tree for NUP214 (if available) |
Paralogs
for NUP214 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NUP214 gene
- NUP1532 POM121C2 POM121L4P2 POM121L1P2 POM121L22 ENSG000001823562 POM121L72 POM1212
1 SIMAP similar gene for NUP214 using alignment to 10 protein entries: NU214_HUMAN (see all proteins):DKFZp686J0330
NUP214 for paralogs About GeneDecksing
|
Genomic Variants
for NUP214 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NUP214 (134000948 - 134110057 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for NUP214
1 CNV: 3782
1 Indel: 60770 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NUP214 |
|
Disorders
/ Diseases
for NUP214 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NUP214 for disorders About GeneDecksing
OMIM gene information: 114350
OMIM disorders: 601626
UniProtKB/Swiss-Prot: NU214_HUMAN, P35658
Note=A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); alsoknown as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of aDEK-CAN fusion gene Note=A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia(AUL). Translocation t(6;9)(q21;q34.1) with SET
13  diseases for NUP214: About MalaCardsacute myeloid leukemia myeloid leukemia leukemia myelodysplastic syndrome
glucocorticoid resistance acute lymphoblastic leukemia lymphoblastic leukemia myeloid malignancy
hepatitis b t-cell leukemia immunodeficiency ischemia
hepatitis
1 disease from the University of Copenhagen DISEASES database for NUP214:Leukemia 2 Novoseek disease relationships for NUP214 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| t-all |
59 |
1 |
15361874 (1) |
| immunodeficiency |
22.9 |
1 |
9847314 (1) |
Human Genome Epidemiology (HuGE) Navigator: NUP214 (3 documents)
Export disorders for NUP214 gene to outside databases
|
Publications
for NUP214 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NUP214 gene, integrated from 9 sources (see all 110):
(articles sorted by number of sources associating them with NUP214) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human CAN protein, a putative oncogene product associated with myeloid leukemogenesis, is a nuclear pore complex protein that faces the cytoplasm. (PubMed id 8108440)1, 2, 3, 9 Kraemer D.... Radu A. (1994)
- Herpesvirus capsid association with the nuclear pore complex and viral DNA release involve the nucleoporin CAN/Nup214 and the capsid protein pUL25. (PubMed id 19386703)1, 2 Pasdeloup D....Rixon F.J. (2009)
- The mRNA export protein DBP5 binds RNA and the cytoplasmic nucleoporin NUP214 in a mutually exclusive manner. (PubMed id 19219046)1, 2 von Moeller H....Conti E. (2009)
- Crystal structure of the N-terminal domain of the human protooncogene Nup214/CAN. (PubMed id 17264208)1, 2 Napetschnig J....Hoelz A. (2007)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Exportin-5, a novel karyopherin, mediates nuclear export of double- stranded RNA binding proteins. (PubMed id 11777942)1, 2 Brownawell A.M. and Macara I.G. (2002)
- The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and the novel nuclear pore component Nup88. (PubMed id 9049309)1, 2 Fornerod M.... Grosveld G. (1997)
- Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)1, 2 Nomura N.... Tabata S. (1994)
- The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA. (PubMed id 1549122)1, 2 Von Lindern M.... Grosveld G. (1992)
- The (6;9) chromosome translocation, associated with a specific subtype of acute nonlymphocytic leukemia, leads to aberrant transcription of a target gene on 9q34. (PubMed id 2370860)1, 3 von Lindern M....Grosveld G. (1990)
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External Searches for NUP214 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing NUP214 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing NUP214 gene
(According to HUGE)
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Specialized Databases showing NUP214 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for NUP214 gene:
Search GeneIP for patents involving NUP214
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for NUP214 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NUP214 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NUP214 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUP214 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NUP214 | | OriGene 3'-UTR Clone for NUP214 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUP214 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUP214 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NUP214 | | OriGene Custom Protein Services for NUP214 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NUP214 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NUP214 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUP214 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUP214 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUP214 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUP214 |
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| | | | Search Tocris compounds for NUP214 |
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 | | | NUP214 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUP214 |
|  |  |  | | | | ThermoFisher Antibody for NUP214 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUP214 |
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