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Aliases for NUP210L Gene

Aliases for NUP210L Gene

  • Nucleoporin 210 Like 2 3 5
  • Nucleoporin 210 KDa-Like 4
  • Nucleoporin 210kDa Like 2
  • Nucleoporin Nup210-Like 4

External Ids for NUP210L Gene

Previous GeneCards Identifiers for NUP210L Gene

  • GC01M150780
  • GC01M152231
  • GC01M153965
  • GC01M125327

Summaries for NUP210L Gene

GeneCards Summary for NUP210L Gene

NUP210L (Nucleoporin 210 Like) is a Protein Coding gene. Among its related pathways are RNA transport. An important paralog of this gene is NUP210.

Additional gene information for NUP210L Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP210L Gene

Genomics for NUP210L Gene

Regulatory Elements for NUP210L Gene

Enhancers for NUP210L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H154177 1.8 FANTOM5 ENCODE dbSUPER 24.8 -25.8 -25765 6 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 NUP210L PYGO2 ENSG00000224784 MIR4258 UBAP2L ENSG00000272654 LOC101928120 C1orf189 SNORA58B HAX1
GH01H154153 1.5 Ensembl ENCODE dbSUPER 24.8 -1.7 -1670 6 HDGF PKNOX1 ATF1 ARNT SIN3A TCF12 GATA2 ELK1 ATF7 RUNX3 NUP210L HAX1 CREB3L4 RN7SL431P GC01M154167
GH01H153955 1.4 ENCODE dbSUPER 25.4 +196.8 196816 5 HDGF PKNOX1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF766 ZNF207 ZNF143 NUP210L UBAP2L CRTC2 SLC27A3 ILF2 INTS3 CREB3L4 CHTOP RAB13 DENND4B
GH01H154998 1.9 FANTOM5 ENCODE dbSUPER 12.6 -849.3 -849336 11 MLX YBX1 DMAP1 YY1 ZNF416 ZNF143 SP3 NFYC ZC3H11A PPARGC1A GON4L CLK2 UBAP2L KIAA0907 ENSG00000271267 MSTO1 RUSC1-AS1 THBS3 YY1AP1 FLAD1
GH01H154606 1.7 FANTOM5 ENCODE dbSUPER 12.6 -453.3 -453349 4 HDGF ARNT ARID4B SIN3A FEZF1 YBX1 ZNF2 YY1 ZNF143 ZNF207 CLK2 CHRNB2 ENSG00000271267 UBAP2L ILF2 FLAD1 MIR4258 DAP3P1 RUSC1-AS1 CREB3L4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NUP210L on UCSC Golden Path with GeneCards custom track

Genomic Location for NUP210L Gene

Chromosome:
1
Start:
153,992,685 bp from pter
End:
154,155,116 bp from pter
Size:
162,432 bases
Orientation:
Minus strand

Genomic View for NUP210L Gene

Genes around NUP210L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUP210L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUP210L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP210L Gene

Proteins for NUP210L Gene

  • Protein details for NUP210L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VU65-P210L_HUMAN
    Recommended name:
    Nuclear pore membrane glycoprotein 210-like
    Protein Accession:
    Q5VU65
    Secondary Accessions:
    • E7EP56
    • Q5T4L7
    • Q6ZRN1
    • Q6ZRT4
    • Q6ZU81
    • Q8NDI6
    • Q9UF31

    Protein attributes for NUP210L Gene

    Size:
    1888 amino acids
    Molecular mass:
    210605 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC86345.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC87279.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB63757.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for NUP210L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUP210L Gene

Post-translational modifications for NUP210L Gene

  • Glycosylation at posLast=8484, posLast=304304, Asn348, posLast=495495, posLast=522522, posLast=812812, posLast=931931, posLast=14451445, and posLast=18591859
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NUP210L Gene

Domains & Families for NUP210L Gene

Gene Families for NUP210L Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted membrane proteins

Protein Domains for NUP210L Gene

Suggested Antigen Peptide Sequences for NUP210L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5VU65

UniProtKB/Swiss-Prot:

P210L_HUMAN :
  • Belongs to the NUP210 family.
Family:
  • Belongs to the NUP210 family.
genes like me logo Genes that share domains with NUP210L: view

Function for NUP210L Gene

Phenotypes From GWAS Catalog for NUP210L Gene

genes like me logo Genes that share phenotypes with NUP210L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NUP210L
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NUP210L Gene

Localization for NUP210L Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP210L Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUP210L gene
Compartment Confidence
plasma membrane 3
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NUP210L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NUP210L: view

Pathways & Interactions for NUP210L Gene

SuperPathways for NUP210L Gene

SuperPathway Contained pathways
1 RNA transport
genes like me logo Genes that share pathways with NUP210L: view

Pathways by source for NUP210L Gene

1 KEGG pathway for NUP210L Gene

Interacting Proteins for NUP210L Gene

Gene Ontology (GO) - Biological Process for NUP210L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007286 spermatid development IEA --
GO:0060009 Sertoli cell development IEA --
genes like me logo Genes that share ontologies with NUP210L: view

No data available for SIGNOR curated interactions for NUP210L Gene

Drugs & Compounds for NUP210L Gene

No Compound Related Data Available

Transcripts for NUP210L Gene

Unigene Clusters for NUP210L Gene

Nucleoporin 210kDa-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NUP210L
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NUP210L Gene

No ASD Table

Relevant External Links for NUP210L Gene

GeneLoc Exon Structure for
NUP210L
ECgene alternative splicing isoforms for
NUP210L

Expression for NUP210L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUP210L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NUP210L Gene

This gene is overexpressed in Testis (x37.6).

Protein differential expression in normal tissues from HIPED for NUP210L Gene

This gene is overexpressed in Ovary (40.4) and Testis (23.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NUP210L Gene



Protein tissue co-expression partners for NUP210L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NUP210L Gene:

NUP210L

SOURCE GeneReport for Unigene cluster for NUP210L Gene:

Hs.67639

Evidence on tissue expression from TISSUES for NUP210L Gene

  • Blood(2.8)
  • Lymph node(2.7)
  • Adrenal gland(2.6)
  • Intestine(2.6)
  • Lung(2.6)
  • Spleen(2.6)
  • Thyroid gland(2.6)
  • Bone marrow(2.5)
  • Eye(2.5)
  • Kidney(2.4)
  • Pancreas(2.4)
  • Skin(2.4)
  • Heart(2.3)
  • Liver(2.3)
  • Nervous system(2.3)
  • Muscle(2)
genes like me logo Genes that share expression patterns with NUP210L: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUP210L Gene

Orthologs for NUP210L Gene

This gene was present in the common ancestor of animals.

Orthologs for NUP210L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUP210L 33 34
  • 99.61 (n)
cow
(Bos Taurus)
Mammalia NUP210L 33 34
  • 89.86 (n)
dog
(Canis familiaris)
Mammalia NUP210L 33 34
  • 89.35 (n)
mouse
(Mus musculus)
Mammalia Nup210l 33 16 34
  • 83.43 (n)
rat
(Rattus norvegicus)
Mammalia Nup210l 33
  • 83.07 (n)
oppossum
(Monodelphis domestica)
Mammalia NUP210L 34
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 70 (a)
OneToMany
-- 34
  • 56 (a)
OneToMany
-- 34
  • 31 (a)
OneToMany
chicken
(Gallus gallus)
Aves NUP210L 33 34
  • 64.47 (n)
lizard
(Anolis carolinensis)
Reptilia NUP210L 34
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta gp210 34
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea npp-12 34
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 30 (a)
OneToMany
Species where no ortholog for NUP210L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for NUP210L Gene

ENSEMBL:
Gene Tree for NUP210L (if available)
TreeFam:
Gene Tree for NUP210L (if available)

Paralogs for NUP210L Gene

Paralogs for NUP210L Gene

(1) SIMAP similar genes for NUP210L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NUP210L: view

Variants for NUP210L Gene

Sequence variations from dbSNP and Humsavar for NUP210L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000040094 -- 154,090,028(+) GCCAT(A/G)TTCAT intron-variant
rs1000079794 -- 154,141,909(+) GTAAT(C/T)CCAGC intron-variant
rs1000102785 -- 154,108,145(+) TTAAA(C/G)TGTAG intron-variant
rs1000112073 -- 154,010,705(+) GTCTC(C/T)ACTAA intron-variant
rs1000116325 -- 154,003,328(+) TCAGC(C/T)TCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUP210L Gene

Variant ID Type Subtype PubMed ID
esv2063006 CNV deletion 18987734
esv2586978 CNV deletion 19546169
esv2648729 CNV loss 19546169
esv2660112 CNV deletion 23128226
esv2718306 CNV deletion 23290073
esv3310079 CNV mobile element insertion 20981092
esv3383476 CNV insertion 20981092
esv3417021 CNV insertion 20981092
esv3578197 CNV loss 25503493
esv3587597 CNV loss 21293372
esv3587598 CNV loss 21293372
nsv1000153 CNV gain 25217958
nsv520398 CNV gain+loss 19592680
nsv946401 CNV duplication 23825009

Variation tolerance for NUP210L Gene

Residual Variation Intolerance Score: 3.93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.46; 92.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUP210L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUP210L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUP210L Gene

Disorders for NUP210L Gene

Relevant External Links for NUP210L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUP210L

No disorders were found for NUP210L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUP210L Gene

Publications for NUP210L Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 60
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 60
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 60

Products for NUP210L Gene

Sources for NUP210L Gene

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