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NUP210L Gene

protein-coding   GIFtS: 42
GCID: GC01M153965

Nucleoporin 210kDa-Like

  Search for NUP210L
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nucleoporin 210kDa-Like1 2
Nucleoporin Nup210-Like2 3
Nuclear Pore Membrane Glycoprotein 210-Like2
Nuclear Pore Membrane Glycoprotein 210-Like (LOC91181)2
Nucleoporin 210 KDa-Like3

External Ids:    HGNC: 299151   Entrez Gene: 911812   Ensembl: ENSG000001435527   UniProtKB: Q5VU653   

Export aliases for NUP210L gene to outside databases

Previous GC identifers: GC01M150780 GC01M152231 GC01M125327


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NUP210L Gene:
NUP210L (nucleoporin 210kDa-like) is a protein-coding gene. An important paralog of this gene is NUP210.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NUP210L gene promoter:
         AhR   SRF   AML1a   SRF (504 AA)   CUTL1   GATA-1   Arnt   POU2F1   POU2F1a   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNUP210L promoter sequence
   Search Chromatin IP Primers for NUP210L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NUP210L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.3

NUP210L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUP210L gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M153965:  view genomic region     (about GC identifiers)

Start:
153,965,161 bp from pter      End:
154,127,592 bp from pter
Size:
162,432 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: P210L_HUMAN, Q5VU65 (See protein sequence)
Recommended Name: Nuclear pore membrane glycoprotein 210-like precursor  
Size: 1888 amino acids; 210605 Da
Sequence caution: Sequence=BAC86345.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAC87279.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAB63757.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: E7EP56 Q5T4L7 Q6ZRN1 Q6ZRT4 Q6ZU81 Q8NDI6 Q9UF31
Alternative splicing: 2 isoforms:  Q5VU65-1   Q5VU65-2   

Explore the universe of human proteins at neXtProt for NUP210L: NX_Q5VU65

Explore proteomics data for NUP210L at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn84, Asn304, Asn348, Asn495, Asn522, Asn812, Asn931, Asn1445, Asn1859
  • Modification sites at PhosphoSitePlus

  • See NUP210L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001152956.1  NP_997191.2  

    ENSEMBL proteins: 
     ENSP00000357547   ENSP00000357541   ENSP00000271854  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR003343 Big_2
     IPR008964 Invasin/intimin_cell_adhesion

    Graphical View of Domain Structure for InterPro Entry Q5VU65

    ProtoNet protein and cluster: Q5VU65

    1 Blocks protein domain: IPB003343 Bacterial Ig-like

    UniProtKB/Swiss-Prot: P210L_HUMAN, Q5VU65
    Similarity: Belongs to the NUP210 family


    NUP210L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NUP210L
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NUP210L

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NUP210L
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NUP210L

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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    P210L_HUMAN, Q5VU65: Membrane; Single-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    endoplasmic reticulum1
    extracellular1
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    NUP210L for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NUP210L About    
    See pathways by source

    SuperPathContained pathways About
    1RNA transport
    RNA transport

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for NUP210L):
        RNA transport


    NUP210L for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NUP210L
    Interactions:

        Search GeneGlobe Interaction Network for NUP210L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NUP210L (ENSP000003575474) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATP2B4ENSP000003503104STRING: ENSP00000350310
    FCGR1AENSP000003581654STRING: ENSP00000358165
    NUP93ENSP000003106684STRING: ENSP00000310668
    DNAJC3ENSP000003659914STRING: ENSP00000365991
    LAMA3ENSP000003245324STRING: ENSP00000324532
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007286spermatid development IEA--
    GO:0060009Sertoli cell development IEA--

    NUP210L for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NUP210L (P210L)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NUP210L gene (2 alternative transcripts): 
    NM_001159484.1  NM_207308.2  

    Unigene Cluster for NUP210L:

    Nucleoporin 210kDa-like
    Hs.67639  [show with all ESTs]
    Unigene Representative Sequence: NM_207308
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368559(uc009woq.3 uc001fdw.3 uc010peh.2) ENST00000368553
    ENST00000271854
    miRNA
    Products:
         
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    SwitchGear 3'UTR luciferase reporter plasmidNUP210L 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NUP210L
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat NUP210L
      QuantiFast Probe-based Assays in human, mouse, rat NUP210L

    Additional mRNA sequence: 

    AK125924.1 AK128000.1 AK128108.1 AL133633.1 AL833964.1 BX648132.1 

    3 DOTS entries:

    DT.206359  DT.101981855  DT.95079270 

    Selected AceView cDNA sequences (see all 1845):

    BG284581 BQ876654 BM835944 CA413501 BU844961 AA369774 AW651625 AA211692 
    BG107137 AW337645 CD673504 BM786005 BU190979 AA339022 AA969824 AW474755 
    AI650799 BQ684921 BQ723572 F25683 BX095105 AA180901 BX103467 BU508189 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NUP210L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NUP210L Expression
    About this image


    NUP210L expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Heart (Cardiovascular System)
             Cardiac Fibroblasts Myocardium
     
     Fibroblasts
             Cardiac Fibroblasts Myocardium
     
     Testis (Reproductive System)
    NUP210L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NUP210L Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.67639
        Custom PCR Arrays for NUP210L
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NUP210L gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nup210l1 , 5 nucleoporin 210-like1, 5 83.43(n)1
    83.43(a)1
      3 (39.20 cM)5
    775951  NM_029937.11  NP_084213.11 
     901041325 
    chicken
    (Gallus gallus)
    Aves NUP210L1 nucleoporin 210kDa-like 64.47(n)
    58.92(a)
      426146  XM_004948277.1  XP_004948334.1 
    lizard
    (Anolis carolinensis)
    Reptilia NUP210L6
    nucleoporin 210kDa-like
    60(a)
    1 ↔ 1
    GL343805.1(57187-100770)
    fruit fly
    (Drosophila melanogaster)
    Insecta gp2106
    gp210
    21(a)
    1 → many
    2R(1648373-1660077)
    worm
    (Caenorhabditis elegans)
    Secernentea npp-126
    Protein NPP-12 (npp-12) mRNA, complete cds
    19(a)
    1 → many
    I(6447309-6453949) WBGene00003798


    ENSEMBL Gene Tree for NUP210L (if available)
    TreeFam Gene Tree for NUP210L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NUP210L gene
    NUP2102  
    1 SIMAP similar gene for NUP210L using alignment to 1 protein entry:     P210L_HUMAN:
    NUP210

    NUP210L for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NUP210L (see all 2794)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs357604111,2
    C--125344514(+) AAAAA-/A/AA  
            
    GGCAT
    2 -- int11NA 2
    rs1415441941,2
    --153965150(+) CAATAC/GAGTCT 2 -- ds5001 int10--------
    rs1508939761,2
    --153965211(+) GAAGCC/TTTATC 2 -- ut310--------
    rs1858005121,2
    --153965278(+) ATTCCC/TCTGCA 2 -- ut310--------
    rs1999817321,2
    C--153965306(+) CAAGCA/GGAGGT 2 -- ut310--------
    rs617389451,2
    C,F--153965322(+) CCTTAT/CACTCC 4 /I /V mis13Minor allele frequency- C:0.01NS WA EU 1315
    rs1910579661,2
    C--153965358(+) GGCCAA/GTGGAG 4 L syn10--------
    rs2019229571,2
    --153965590(+) TGTCAC/TAAGGC 2 -- int10--------
    rs1141655251,2
    C,F--153965609(+) GGAAGG/TCCTTA 2 -- int11Minor allele frequency- T:0.06WA 118
    rs1829045211,2
    --153965770(+) GGGCAC/TGGTGG 2 -- int10--------

    HapMap Linkage Disequilibrium report for NUP210L (153965161 - 154127592 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for NUP210L:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2063006CNV Deletion18987734
    esv2718306CNV Deletion23290073
    esv2586978CNV Deletion19546169
    esv2660112CNV Deletion23128226
    esv274351CNV Insertion20981092
    esv267891CNV Insertion20981092
    esv2648729CNV Loss19546169
    nsv872451CNV Gain21882294
    nsv520398CNV Gain+Loss19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NUP210L gene integrated from 10 sources:
    (articles sorted by number of sources associating them with NUP210L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    4. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 91181 HGNC: 29915 AceView: TPM3 Ensembl:ENSG00000143552 euGenes: HUgn91181
    ECgene: NUP210L Kegg: 91181 H-InvDB: NUP210L

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NUP210L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NUP210L gene:
    Search GeneIP for patents involving NUP210L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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