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NUP210 Gene

protein-coding   GIFtS: 60
GCID: GC03M013548

Nucleoporin 210kDa

  Search for NUP210
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nucleoporin 210kDa1 2     POM2102 3
Nuclear Envelope Pore Membrane Protein POM 2102 3     GP2102 5
Nuclear Pore Protein Gp2102 3     KIAA09063 5
Nucleoporin Nup2102 3     Nuclear Pore Membrane Glycoprotein 2102
Pore Membrane Protein Of 210 KDa2 3     

External Ids:    HGNC: 300521   Entrez Gene: 232252   Ensembl: ENSG000001321827   OMIM: 6077035   UniProtKB: Q8TEM13   

Export aliases for NUP210 gene to outside databases

Previous GC identifers: GC03U990118 GC03M013297 GC03M013332 GC03M013420


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NUP210 Gene:
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that
regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components
of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a membrane-spanning
glycoprotein that is a major component of the nuclear pore complex. Multiple pseudogenes related to this gene are
located on chromosome 3. (provided by RefSeq, Jul 2013)

GeneCards Summary for NUP210 Gene:
NUP210 (nucleoporin 210kDa) is a protein-coding gene. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is NUP210L.

UniProtKB/Swiss-Prot: PO210_HUMAN, Q8TEM1
Function: Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural
integrity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NUP210 gene promoter:
         RP58   Lmo2   HSF1 (long)   Nkx5-1   E47   GATA-1   AREB6   HEN1   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNUP210 promoter sequence
   Search Chromatin IP Primers for NUP210

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NUP210


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.1   Ensembl cytogenetic band:  3p25.1   HGNC cytogenetic band: 3p25

NUP210 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUP210 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M013548:  view genomic region     (about GC identifiers)

Start:
13,357,737 bp from pter      End:
13,461,809 bp from pter
Size:
104,073 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PO210_HUMAN, Q8TEM1 (See protein sequence)
Recommended Name: Nuclear pore membrane glycoprotein 210 precursor  
Size: 1887 amino acids; 205111 Da
Subunit: Forms dimers and possibly higher-order oligomers (By similarity)
Miscellaneous: Recognized by antinuclear autoantibodies in primary biliary cirrhosis
Miscellaneous: Knockdown of NUP210 causes nuclear membranes to accumulate aberrant structures termed twinned and
fusion-arrested membranes and nuclear pore complex to cluster. Induces cell death and chromatin disruptions
Sequence caution: Sequence=BAB15332.1; Type=Erroneous initiation; Sequence=BAC11688.1; Type=Erroneous initiation;
Secondary accessions: A6NN56 O94980 Q6NXG6 Q8NBJ1 Q9H6C8 Q9UFP3
Alternative splicing: 2 isoforms:  Q8TEM1-1   Q8TEM1-2   

Explore the universe of human proteins at neXtProt for NUP210: NX_Q8TEM1

Explore proteomics data for NUP210 at MOPED

Post-translational modifications: 

  • N-glycosylated, but not all potential glycosylation sites may be used. Contains high-mannose type oligosaccharides
    (By similarity)1
  • Phosphorylated at Ser-1881 in mitosis specifically; not phosphorylated in interphase (By similarity)1
  • Ubiquitination2 at Lys32, Lys79, Lys201, Lys212, Lys228, Lys774, Lys1020, Lys1063, Lys1258, Lys1576,
                                 Lys1724, Lys1872
  • Glycosylation2 at Asn44, Asn337, Asn405, Asn484, Asn681, Asn801, Asn926, Asn1039, Asn1116, Asn1135,
                                 Asn1362, Asn1441
  • Modification sites at PhosphoSitePlus

  • See NUP210 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079199.2  
    ENSEMBL proteins: 
     ENSP00000254508  
    Reactome Protein details: Q8TEM1

    NUP210 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals NUP210 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NUP210

     
    Search eBioscience for Proteins for NUP210 

    NUP210 Antibody Products:

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    Abcam antibodies for NUP210
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    ThermoFisher Antibodies for NUP210
    LSBio Antibodies in human, mouse, rat for NUP210

    NUP210 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for NUP210
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NUP210
    Cloud-Clone Corp. CLIAs for NUP210
    Search eBioscience for ELISAs for NUP210 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR003343 Big_2
     IPR008964 Invasin/intimin_cell_adhesion

    Graphical View of Domain Structure for InterPro Entry Q8TEM1

    ProtoNet protein and cluster: Q8TEM1

    1 Blocks protein domain: IPB003343 Bacterial Ig-like

    UniProtKB/Swiss-Prot: PO210_HUMAN, Q8TEM1
    Similarity: Belongs to the NUP210 family


    Find genes that share domains with NUP210           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PO210_HUMAN, Q8TEM1
    Function: Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural
    integrity

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding ----
    GO:0046983protein dimerization activity IEA--
         
    Find genes that share ontologies with NUP210           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NUP210
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NUP210

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NUP210
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NUP210

    miRNA
    Products:
        
    miRTarBase miRNAs that target NUP210:
    hsa-mir-92a-3p (MIRT049762), hsa-mir-15b-5p (MIRT046399), hsa-mir-1 (MIRT023939), hsa-mir-296-3p (MIRT038351), hsa-mir-1229-3p (MIRT036333), hsa-mir-335-5p (MIRT018659), hsa-mir-221-3p (MIRT046916), hsa-mir-423-3p (MIRT042645), hsa-mir-18a-3p (MIRT040810)

    Block miRNA regulation of human, mouse, rat NUP210 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NUP210 (see all 31):
    hsa-miR-125a-5p hsa-miR-4328 hsa-miR-15a hsa-miR-513a-5p hsa-miR-128 hsa-miR-766 hsa-miR-1297 hsa-miR-223
    SwitchGear 3'UTR luciferase reporter plasmidNUP210 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NUP210
    Predesigned siRNA for gene silencing in human, mouse, rat NUP210

    Gene Editing
    Products:
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    Clone
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    OriGene clones in human, mouse for NUP210 (see all 6)
    OriGene ORF clones in mouse, rat for NUP210
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NUP210 (NM_024923)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUP210
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUP210

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for NUP210 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUP210


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PO210_HUMAN, Q8TEM1: Nucleus, nuclear pore complex. Nucleus membrane; Single-pass type I membrane protein.
    Endoplasmic reticulum membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    nucleus5
    plasma membrane3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope TAS--
    GO:0005643nuclear pore IEA--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016020membrane ----
    GO:0031965nuclear membrane IEA--

    Find genes that share ontologies with NUP210           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NUP210 About   (see all 14)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Regulation of Glucokinase by Glucokinase Regulatory Protein
    Transport of the SLBP Dependant Mature mRNA0.92
    Export of Viral Ribonucleoproteins from Nucleus0.88
    Transport of Mature mRNAs Derived from Intronless Transcripts0.92
    Transport of Ribonucleoproteins into the Host Nucleus0.88
    Transport of the SLBP independent Mature mRNA0.91
    Regulation of Glucokinase by Glucokinase Regulatory Protein0.87
    Nuclear import of Rev protein0.91
    Glucose transport0.87
    2HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    Host Interactions of HIV factors0.60
    3Interferon Signaling
    Interferon Signaling0.59
    ISG15 antiviral mechanism0.42
    Cytokine Signaling in Immune system0.59
    Antiviral mechanism by IFN-stimulated genes0.42
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    5Transport of Mature Transcript to Cytoplasm
    Transport of Mature Transcript to Cytoplasm0.93
    Transport of Mature mRNA derived from an Intron-Containing Transcript0.93


    Find genes that share SuperPaths with NUP210           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected Reactome Pathways for NUP210 (see all 6)
        Rev-mediated nuclear export of HIV RNA
    Regulation of Glucokinase by Glucokinase Regulatory Protein
    Nuclear import of Rev protein
    Nuclear Pore Complex (NPC) Disassembly
    Vpr-mediated nuclear import of PICs


    1 Kegg Pathway  (Kegg details for NUP210):
        RNA transport

        Pathway & Disease-focused RT2 Profiler PCR Array including NUP210: 
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NUP210

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NUP210 (Q8TEM13 ENSP000002545084) via UniProtKB, MINT, STRING, and/or I2D (see all 113)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EXOSC5Q9NQT43, ENSP000002212334I2D: score=4 STRING: ENSP00000221233
    TRIP6Q156543, ENSP000002004574I2D: score=2 STRING: ENSP00000200457
    CDK1P064933I2D: score=2 
    ATG14Q6ZNE53I2D: score=1 
    ATG2AQ2TAZ03I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0007077mitotic nuclear envelope disassembly TAS--
    GO:0008645hexose transport TAS--
    GO:0010827regulation of glucose transport TAS--

    Find genes that share ontologies with NUP210           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NUP210 (PO210)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NUP210 gene: 
    NM_024923.3  

    Unigene Cluster for NUP210:

    Nucleoporin 210kDa
    Hs.475525  [show with all ESTs]
    Unigene Representative Sequence: NM_024923
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000254508(uc003bxv.1) ENST00000485755 ENST00000479519(uc003bxw.3)
    ENST00000420141(uc003bxx.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NUP210 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NUP210 (see all 31):
    hsa-miR-125a-5p hsa-miR-4328 hsa-miR-15a hsa-miR-513a-5p hsa-miR-128 hsa-miR-766 hsa-miR-1297 hsa-miR-223
    SwitchGear 3'UTR luciferase reporter plasmidNUP210 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NUP210
    Predesigned siRNA for gene silencing in human, mouse, rat NUP210
    Clone
    Products:
         
    OriGene clones in human, mouse for NUP210 (see all 6)
    OriGene ORF clones in mouse, rat for NUP210
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NUP210 (NM_024923)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUP210
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUP210
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for NUP210
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NUP210
      QuantiTect SYBR Green Assays in human, mouse, rat NUP210
      QuantiFast Probe-based Assays in human, mouse, rat NUP210

    Additional mRNA sequence: 

    AB020713.1 AK026042.1 AK074101.1 AK075545.1 AK225409.1 AL117527.1 BC020573.1 BC067089.1 
    BC068109.1 

    12 DOTS entries:

    DT.101960732  DT.452801  DT.403002  DT.95250157  DT.100781092  DT.100759786  DT.120888581  DT.40226159 
    DT.91773402  DT.99966218  DT.95250367  DT.99932807 

    Selected AceView cDNA sequences (see all 432):

    AI023554 AI802599 BE551444 AI348572 AA687290 BQ721094 AI216187 AI380071 
    AI215821 AA347047 BE327534 BM698800 CD367817 BF477598 BU541934 AI291215 
    AI818912 AA679845 BE218924 AI814038 BI826015 AA436286 AI290867 AI218972 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for NUP210    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b ^
    SP1:                                                                                                                                -     -     -               
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            

    ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35a · 35b ^ 36a · 36b ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42
    SP1:                                                                    -                                                         
    SP2:                                                                                                                              
    SP3:                                                                                                                              
    SP4:                                                                                                                              


    ECgene alternative splicing isoforms for NUP210

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NUP210 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGTTGATTT
    NUP210 Expression
    About this image


    NUP210 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Endothelium (Cardiovascular System)
             Mature Endothelial Cells Blood Brain Barrier
     
     Bone (Muscoskeletal System)
             Chondrocytes Zeugopod Epiphyseal End
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Cartilage (Muscoskeletal System)
             Chondrocytes Zeugopod Epiphyseal End
     
     Brain (Nervous System)
             Mature Endothelial Cells Blood Brain Barrier
    NUP210 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NUP210 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.475525

    UniProtKB/Swiss-Prot: PO210_HUMAN, Q8TEM1
    Tissue specificity: Ubiquitous expression, with highest levels in lung, liver, pancreas, testis, and ovary,
    intermediate levels in brain, kidney, and spleen, and lowest levels in heart and skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Array including NUP210: 
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for NUP210
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NUP210
    QuantiTect SYBR Green Assays in human, mouse, rat NUP210
    QuantiFast Probe-based Assays in human, mouse, rat NUP210
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUP210

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NUP210 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nup2101 , 5 nucleoporin 2101, 5 83.15(n)1
    85.16(a)1
      6 (40.30 cM)5
    545631  NM_018815.21  NP_061285.21 
     910130685 
    chicken
    (Gallus gallus)
    Aves NUP2101 nucleoporin 210kDa 68.39(n)
    73.59(a)
      415977  XM_414320.4  XP_414320.3 
    lizard
    (Anolis carolinensis)
    Reptilia NUP2106
    nucleoporin 210kDa
    61(a)
    1 ↔ 1
    3(95603733-95769860)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia nup2101 nucleoporin 210kDa 64.62(n)
    62(a)
      100493693  XM_002943657.2  XP_002943703.2 
    zebrafish
    (Danio rerio)
    Actinopterygii nup2101 nucleoporin 210 63.61(n)
    62.16(a)
      570945  XM_002667560.3  XP_002667606.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta gp2101 gp210 43.12(n)
    29.3(a)
      35512  NM_001273785.1  NP_001260714.1 
    worm
    (Caenorhabditis elegans)
    Secernentea npp-121 npp-12 40.08(n)
    29.33(a)
      172348  NM_059454.3  NP_491855.1 


    ENSEMBL Gene Tree for NUP210 (if available)
    TreeFam Gene Tree for NUP210 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NUP210 gene
    NUP210L2  
    1 SIMAP similar gene for NUP210 using alignment to 1 protein entry:     PO210_HUMAN:
    NUP210L

    Find genes that share paralogs with NUP210           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for NUP210
    PGOHUM00000237538 PGOHUM00000237765 PGOHUM00000237936 PGOHUM00000250302


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NUP210 (see all 2490)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1468711061,2
    Cuntested113399818(+) CAGACA/C/GAACTT 2 F syn11NA 4552
    rs1438200931,2
    C--13357271(+) AAAAC-/AAAAAA 1 -- ds50010--------
    rs2002877561,2
    C--13357278(+) AAAAA-/A/AA  
            
    CATTT
    1 -- ds50010--------
    rs1809632201,2
    --13357336(+) AAACAC/GAGAAC 1 -- ds50010--------
    rs1454141911,2
    --13357342(+) AGAACA/GAGAGT 1 -- ds50010--------
    rs1450124791,2
    --13357746(+) AATCAC/TATAGA 1 -- ut310--------
    rs1490728321,2
    --13357834(+) ACAATC/TCTTCC 1 -- ut310--------
    rs1422237901,2
    C--13357902(+) CTTGTA/GCGGGA 1 -- ut310--------
    rs1852493311,2
    --13357903(+) TTGTGC/TGGGAT 1 -- ut310--------
    rs1458845421,2
    C--13357912(+) ATCCCA/C/GTCATC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for NUP210 (13357737 - 13461809 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for NUP210:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2724941CNV Deletion23290073
    nsv3706CNV Insertion18451855
    nsv876550CNV Loss21882294
    nsv876549CNV Loss21882294
    nsv876551CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NUP210
    DNA2.0 Custom Variant and Variant Library Synthesis for NUP210

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607703    OMIM disorders: --


    Find genes that share disorders with NUP210           About GenesLikeMe

    Genetic Association Database (GAD): NUP210
    Human Genome Epidemiology (HuGE) Navigator: NUP210 (3 documents)

    Export disorders for NUP210 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NUP210 gene, integrated from 10 sources (see all 54):
    (articles sorted by number of sources associating them with NUP210)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A major glycoprotein of the nuclear pore complex is a membrane-spanning polypeptide with a large lumenal domain and a small cytoplasmic tail. (PubMed id 2184032)1, 3, 9 Greber U.F....Gerace L. (EMBO J. 1990)
    2. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (Am. J. Hypertens. 2010)
    3. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)1, 2 Muzny D.M....Gibbs R.A. (Nature 2006)
    6. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Nuclear pore protein gp210 is essential for viability in HeLa cells and Caenorhabditis elegans. (PubMed id 14517331)1, 2 Cohen M.... Gruenbaum Y. (Mol. Biol. Cell 2003)
    10. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2 Nagase T.... Ohara O. (DNA Res. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23225 HGNC: 30052 AceView: NUP210 Ensembl:ENSG00000132182 euGenes: HUgn23225
    ECgene: NUP210 Kegg: 23225 H-InvDB: NUP210

    (According to HUGE)
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    HUGE: KIAA0906

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NUP210 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NUP210 gene:
    Search GeneIP for patents involving NUP210

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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