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Aliases for NUP210 Gene

Aliases for NUP210 Gene

  • Nucleoporin 210 2 3 5
  • Nuclear Envelope Pore Membrane Protein POM 210 3 4
  • Pore Membrane Protein Of 210 KDa 3 4
  • Nuclear Pore Protein Gp210 3 4
  • Nucleoporin 210kDa 2 3
  • Nucleoporin Nup210 3 4
  • POM210 3 4
  • Nuclear Pore Membrane Glycoprotein 210 3
  • KIAA0906 4
  • GP210 3

External Ids for NUP210 Gene

Previous GeneCards Identifiers for NUP210 Gene

  • GC03U990118
  • GC03M013297
  • GC03M013332
  • GC03M013420
  • GC03M013548
  • GC03M013607
  • GC03M013634
  • GC03M013756
  • GC03M013880

Summaries for NUP210 Gene

Entrez Gene Summary for NUP210 Gene

  • The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a membrane-spanning glycoprotein that is a major component of the nuclear pore complex. Multiple pseudogenes related to this gene are located on chromosome 3. [provided by RefSeq, Jul 2013]

GeneCards Summary for NUP210 Gene

NUP210 (Nucleoporin 210) is a Protein Coding gene. Diseases associated with NUP210 include Autoimmune Disease Of Urogenital Tract and Primary Biliary Cirrhosis. Among its related pathways are Interferon gamma signaling and Transport of the SLBP independent Mature mRNA. GO annotations related to this gene include calcium ion binding and protein dimerization activity. An important paralog of this gene is NUP210L.

UniProtKB/Swiss-Prot for NUP210 Gene

  • Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP210 Gene

Genomics for NUP210 Gene

Regulatory Elements for NUP210 Gene

Enhancers for NUP210 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F013351 1 ENCODE 20.6 +67.1 67145 2.4 HDGF PKNOX1 ARNT ARID4B YY1 GLIS2 FOS JUNB NCOA1 PPARG NUP210 HDAC11 HDAC11-AS1 IQSEC1
GH03F013412 1.5 FANTOM5 ENCODE 12.6 +2.6 2649 10.0 HDGF PKNOX1 MLX ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZNF766 NUP210 IQSEC1
GH03F013331 0.8 ENCODE 20.8 +87.8 87784 2.3 HDGF PKNOX1 MXI1 TBL1XR1 MAX ZIC2 RELA ZFHX2 POLR2A ELK1 NUP210 IQSEC1
GH03F013450 1.8 FANTOM5 Ensembl ENCODE 8.8 -31.7 -31682 2.4 PKNOX1 ARNT ARID4B SIN3A YBX1 YY1 SLC30A9 ZNF143 FOS KLF13 ENSG00000228242 NUP210 GC03P013444 ENSG00000238138
GH03F013429 1 ENCODE 10.9 -9.1 -9105 0.4 ATF1 MLX ARID4B DMAP1 ZNF48 YY1 SP5 NFYC MXD4 MIER2 NUP210 GC03P013426 PIR38600
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NUP210 on UCSC Golden Path with GeneCards custom track

Promoters for NUP210 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001357893 119 2001 HDGF PKNOX1 MLX ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZNF143

Genomic Location for NUP210 Gene

Chromosome:
3
Start:
13,316,230 bp from pter
End:
13,420,319 bp from pter
Size:
104,090 bases
Orientation:
Minus strand

Genomic View for NUP210 Gene

Genes around NUP210 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUP210 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUP210 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP210 Gene

Proteins for NUP210 Gene

  • Protein details for NUP210 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TEM1-PO210_HUMAN
    Recommended name:
    Nuclear pore membrane glycoprotein 210
    Protein Accession:
    Q8TEM1
    Secondary Accessions:
    • A6NN56
    • O94980
    • Q6NXG6
    • Q8NBJ1
    • Q9H6C8
    • Q9UFP3

    Protein attributes for NUP210 Gene

    Size:
    1887 amino acids
    Molecular mass:
    205111 Da
    Quaternary structure:
    • Forms dimers and possibly higher-order oligomers.
    Miscellaneous:
    • Knockdown of NUP210 causes nuclear membranes to accumulate aberrant structures termed twinned and fusion-arrested membranes and nuclear pore complex to cluster. Induces cell death and chromatin disruptions.
    • Recognized by antinuclear autoantibodies in primary biliary cirrhosis.
    SequenceCaution:
    • Sequence=BAB15332.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11688.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NUP210 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUP210 Gene

Post-translational modifications for NUP210 Gene

  • N-glycosylated, but not all potential glycosylation sites may be used. Contains high-mannose type oligosaccharides (By similarity).
  • Phosphorylated at Ser-1881 in mitosis specifically; not phosphorylated in interphase.
  • Ubiquitination at Lys 32, Lys 79, Lys 201, Lys 212, Lys 228, Lys 774, Lys 1020, Lys 1063, Lys 1258, Lys 1576, and Lys 1724
  • Glycosylation at Asn 44, Asn 337, Asn 405, Asn 484, Asn 681, Asn 801, Asn 926, Asn 1039, Asn 1116, Asn 1135, Asn 1362, and Asn 1441
  • Modification sites at PhosphoSitePlus

Other Protein References for NUP210 Gene

No data available for DME Specific Peptides for NUP210 Gene

Domains & Families for NUP210 Gene

Gene Families for NUP210 Gene

Protein Domains for NUP210 Gene

Suggested Antigen Peptide Sequences for NUP210 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TEM1

UniProtKB/Swiss-Prot:

PO210_HUMAN :
  • Belongs to the NUP210 family.
Family:
  • Belongs to the NUP210 family.
genes like me logo Genes that share domains with NUP210: view

Function for NUP210 Gene

Molecular function for NUP210 Gene

UniProtKB/Swiss-Prot Function:
Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity.

Gene Ontology (GO) - Molecular Function for NUP210 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with NUP210: view
genes like me logo Genes that share phenotypes with NUP210: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUP210 Gene

Localization for NUP210 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP210 Gene

Nucleus, nuclear pore complex. Nucleus membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUP210 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 4
plasma membrane 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for NUP210 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope TAS --
GO:0005643 nuclear pore IEA,IBA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA,IDA 19946888
genes like me logo Genes that share ontologies with NUP210: view

Pathways & Interactions for NUP210 Gene

SuperPathways for NUP210 Gene

SuperPathway Contained pathways
1 Transport of the SLBP independent Mature mRNA
2 HIV Life Cycle
.45
3 Cell Cycle, Mitotic
.60
4 Mitotic Prophase
5 Influenza Viral RNA Transcription and Replication
genes like me logo Genes that share pathways with NUP210: view

Pathways by source for NUP210 Gene

Gene Ontology (GO) - Biological Process for NUP210 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006406 mRNA export from nucleus TAS --
GO:0006409 tRNA export from nucleus TAS --
GO:0006810 transport IEA --
GO:0007077 mitotic nuclear envelope disassembly TAS --
GO:0010827 regulation of glucose transport TAS --
genes like me logo Genes that share ontologies with NUP210: view

No data available for SIGNOR curated interactions for NUP210 Gene

Transcripts for NUP210 Gene

Unigene Clusters for NUP210 Gene

Nucleoporin 210kDa:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUP210 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b ^
SP1: - - -
SP2:
SP3:
SP4:

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35a · 35b ^ 36a · 36b ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42
SP1: -
SP2:
SP3:
SP4:

Relevant External Links for NUP210 Gene

GeneLoc Exon Structure for
NUP210
ECgene alternative splicing isoforms for
NUP210

Expression for NUP210 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NUP210 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NUP210 Gene

This gene is overexpressed in Whole Blood (x4.6).

Protein differential expression in normal tissues from HIPED for NUP210 Gene

This gene is overexpressed in Nasal epithelium (24.5), Peripheral blood mononuclear cells (9.4), and Tlymphocyte (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NUP210 Gene



Protein tissue co-expression partners for NUP210 Gene

NURSA nuclear receptor signaling pathways regulating expression of NUP210 Gene:

NUP210

SOURCE GeneReport for Unigene cluster for NUP210 Gene:

Hs.475525

mRNA Expression by UniProt/SwissProt for NUP210 Gene:

Q8TEM1-PO210_HUMAN
Tissue specificity: Ubiquitous expression, with highest levels in lung, liver, pancreas, testis, and ovary, intermediate levels in brain, kidney, and spleen, and lowest levels in heart and skeletal muscle.
genes like me logo Genes that share expression patterns with NUP210: view

Primer Products

Orthologs for NUP210 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUP210 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUP210 34 35
  • 99.06 (n)
dog
(Canis familiaris)
Mammalia NUP210 34 35
  • 86.06 (n)
cow
(Bos Taurus)
Mammalia NUP210 34 35
  • 84.38 (n)
mouse
(Mus musculus)
Mammalia Nup210 34 16 35
  • 83.15 (n)
rat
(Rattus norvegicus)
Mammalia Nup210 34
  • 82.56 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 82 (a)
OneToMany
-- 35
  • 73 (a)
OneToMany
-- 35
  • 60 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia NUP210 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUP210 34 35
  • 68.39 (n)
lizard
(Anolis carolinensis)
Reptilia NUP210 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nup210 34
  • 64.62 (n)
zebrafish
(Danio rerio)
Actinopterygii nup210 34 35
  • 63.61 (n)
fruit fly
(Drosophila melanogaster)
Insecta gp210 34 35
  • 43.12 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006280 34
  • 42.61 (n)
worm
(Caenorhabditis elegans)
Secernentea npp-12 34 35
  • 40.08 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
OneToMany
Species where no ortholog for NUP210 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUP210 Gene

ENSEMBL:
Gene Tree for NUP210 (if available)
TreeFam:
Gene Tree for NUP210 (if available)

Paralogs for NUP210 Gene

Paralogs for NUP210 Gene

(1) SIMAP similar genes for NUP210 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NUP210: view

Variants for NUP210 Gene

Sequence variations from dbSNP and Humsavar for NUP210 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000054 -- 13,390,641(-) AGCTC(C/T)GGGAG intron-variant
rs1048620 -- 13,316,630(-) CGGCC(A/G)CCAGC utr-variant-3-prime
rs1048637 -- 13,316,671(-) CCAGC(A/C)GGCCC utr-variant-3-prime
rs1048650 -- 13,316,704(-) CAGCT(C/T)ATCAG utr-variant-3-prime
rs10575765 -- 13,400,930(+) TCTGA(-/AGG)AGACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUP210 Gene

Variant ID Type Subtype PubMed ID
esv2724941 CNV deletion 23290073
esv3366661 CNV insertion 20981092
esv3425589 CNV duplication 20981092
nsv955315 CNV deletion 24416366
nsv589740 CNV loss 21841781
nsv3706 CNV insertion 18451855

Variation tolerance for NUP210 Gene

Residual Variation Intolerance Score: 58.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.92; 67.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUP210 Gene

Human Gene Mutation Database (HGMD)
NUP210
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUP210

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUP210 Gene

Disorders for NUP210 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NUP210 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
autoimmune disease of urogenital tract
primary biliary cirrhosis
  • biliary liver cirrhosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NUP210

Genetic Association Database (GAD)
NUP210
Human Genome Epidemiology (HuGE) Navigator
NUP210
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUP210
genes like me logo Genes that share disorders with NUP210: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUP210 Gene

Publications for NUP210 Gene

  1. A major glycoprotein of the nuclear pore complex is a membrane-spanning polypeptide with a large lumenal domain and a small cytoplasmic tail. (PMID: 2184032) Greber U.F. … Gerace L. (EMBO J. 1990) 2 3 22 64
  2. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 46 64
  3. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2010) 3 46 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 3 4 64

Products for NUP210 Gene

Sources for NUP210 Gene

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