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Aliases for NUP210 Gene

Aliases for NUP210 Gene

  • Nucleoporin 210 2 3 5
  • Nuclear Envelope Pore Membrane Protein POM 210 3 4
  • Pore Membrane Protein Of 210 KDa 3 4
  • Nuclear Pore Protein Gp210 3 4
  • Nucleoporin 210kDa 2 3
  • Nucleoporin Nup210 3 4
  • POM210 3 4
  • Nuclear Pore Membrane Glycoprotein 210 3
  • KIAA0906 4
  • GP210 3

External Ids for NUP210 Gene

Previous GeneCards Identifiers for NUP210 Gene

  • GC03U990118
  • GC03M013297
  • GC03M013332
  • GC03M013420
  • GC03M013548
  • GC03M013607
  • GC03M013634
  • GC03M013756
  • GC03M013880
  • GC03M013994
  • GC03M014114

Summaries for NUP210 Gene

Entrez Gene Summary for NUP210 Gene

  • The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a membrane-spanning glycoprotein that is a major component of the nuclear pore complex. Multiple pseudogenes related to this gene are located on chromosome 3. [provided by RefSeq, Jul 2013]

GeneCards Summary for NUP210 Gene

NUP210 (Nucleoporin 210) is a Protein Coding gene. Diseases associated with NUP210 include Primary Biliary Cirrhosis and Autoimmune Disease Of Urogenital Tract. Among its related pathways are Transport of the SLBP independent Mature mRNA and Cell Cycle, Mitotic. GO annotations related to this gene include calcium ion binding and protein dimerization activity. An important paralog of this gene is NUP210L.

UniProtKB/Swiss-Prot for NUP210 Gene

  • Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity.

Additional gene information for NUP210 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP210 Gene

Genomics for NUP210 Gene

Regulatory Elements for NUP210 Gene

Enhancers for NUP210 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H013351 1.2 ENCODE dbSUPER 20.6 +67.1 67145 2.4 HDGF PKNOX1 ARNT TCF12 GLIS2 CBX5 FOS ATF7 NCOA1 ZNF592 NUP210 HDAC11-AS1 HDAC11 IQSEC1
GH03H013331 1.1 ENCODE dbSUPER 20.9 +87.8 87784 2.3 PKNOX1 TBL1XR1 BACH1 ZIC2 RELA FOS ATF7 ETV6 RUNX3 IKZF2 NUP210 IQSEC1
GH03H013363 1 dbSUPER 21.1 +55.3 55289 2.5 FOXA2 ATF1 MLX ARID4B DMAP1 ATF7 MXD4 REST MIER2 PPARG NUP210 IQSEC1
GH03H013450 2 FANTOM5 Ensembl ENCODE dbSUPER 8.9 -31.7 -31696 2.2 PKNOX1 ARNT ARID4B SIN3A YBX1 YY1 SLC30A9 ZNF766 ZNF143 FOS XPC ENSG00000228242 NUP210 GC03P013444 ENSG00000238138
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NUP210 on UCSC Golden Path with GeneCards custom track

Promoters for NUP210 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000148796 219 1401 ARID4B SIN3A DMAP1 ZNF766 ELK1 REST SMARCB1 ZNF592 MEF2D MBD2

Genomic Locations for NUP210 Gene

Genomic Locations for NUP210 Gene
104,090 bases
Minus strand

Genomic View for NUP210 Gene

Genes around NUP210 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUP210 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUP210 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP210 Gene

Proteins for NUP210 Gene

  • Protein details for NUP210 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nuclear pore membrane glycoprotein 210
    Protein Accession:
    Secondary Accessions:
    • A6NN56
    • O94980
    • Q6NXG6
    • Q8NBJ1
    • Q9H6C8
    • Q9UFP3

    Protein attributes for NUP210 Gene

    1887 amino acids
    Molecular mass:
    205111 Da
    Quaternary structure:
    • Forms dimers and possibly higher-order oligomers.
    • Knockdown of NUP210 causes nuclear membranes to accumulate aberrant structures termed twinned and fusion-arrested membranes and nuclear pore complex to cluster. Induces cell death and chromatin disruptions.
    • Recognized by antinuclear autoantibodies in primary biliary cirrhosis.
    • Sequence=BAB15332.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11688.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NUP210 Gene


neXtProt entry for NUP210 Gene

Post-translational modifications for NUP210 Gene

  • N-glycosylated, but not all potential glycosylation sites may be used. Contains high-mannose type oligosaccharides (By similarity).
  • Phosphorylated at Ser-1881 in mitosis specifically; not phosphorylated in interphase.
  • Ubiquitination at Lys32, Lys79, Lys201, Lys212, posLast=228228, posLast=774774, posLast=10201020, Lys1063, posLast=12581258, posLast=15761576, and posLast=17241724
  • Glycosylation at Asn44, posLast=337337, Asn405, Asn484, posLast=681681, posLast=801801, Asn926, Asn1039, Asn1116, posLast=11351135, posLast=13621362, and posLast=14411441
  • Modification sites at PhosphoSitePlus

Other Protein References for NUP210 Gene

No data available for DME Specific Peptides for NUP210 Gene

Domains & Families for NUP210 Gene

Gene Families for NUP210 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for NUP210 Gene

Suggested Antigen Peptide Sequences for NUP210 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NUP210 family.
  • Belongs to the NUP210 family.
genes like me logo Genes that share domains with NUP210: view

Function for NUP210 Gene

Molecular function for NUP210 Gene

UniProtKB/Swiss-Prot Function:
Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity.

Phenotypes From GWAS Catalog for NUP210 Gene

Gene Ontology (GO) - Molecular Function for NUP210 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with NUP210: view
genes like me logo Genes that share phenotypes with NUP210: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUP210 Gene

Localization for NUP210 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP210 Gene

Nucleus, nuclear pore complex. Nucleus membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUP210 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 4
plasma membrane 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for NUP210 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope TAS,IEA --
GO:0005643 nuclear pore IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IDA,IEA 19946888
genes like me logo Genes that share ontologies with NUP210: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NUP210 Gene

Pathways & Interactions for NUP210 Gene

SuperPathways for NUP210 Gene

SuperPathway Contained pathways
1 Transport of the SLBP independent Mature mRNA
2 HIV Life Cycle
3 Cell Cycle, Mitotic
4 Mitotic Prophase
5 Influenza Viral RNA Transcription and Replication
genes like me logo Genes that share pathways with NUP210: view

Pathways by source for NUP210 Gene

Gene Ontology (GO) - Biological Process for NUP210 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006110 regulation of glycolytic process TAS --
GO:0006406 mRNA export from nucleus TAS --
GO:0006409 tRNA export from nucleus TAS --
GO:0006810 transport IEA --
GO:0007077 mitotic nuclear envelope disassembly TAS --
genes like me logo Genes that share ontologies with NUP210: view

No data available for SIGNOR curated interactions for NUP210 Gene

Drugs & Compounds for NUP210 Gene

No Compound Related Data Available

Transcripts for NUP210 Gene

Unigene Clusters for NUP210 Gene

Nucleoporin 210kDa:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUP210 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b ^
SP1: - - -

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35a · 35b ^ 36a · 36b ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42
SP1: -

Relevant External Links for NUP210 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NUP210 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUP210 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NUP210 Gene

This gene is overexpressed in Whole Blood (x4.6).

Protein differential expression in normal tissues from HIPED for NUP210 Gene

This gene is overexpressed in Nasal epithelium (24.5), Peripheral blood mononuclear cells (9.4), and Tlymphocyte (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NUP210 Gene

Protein tissue co-expression partners for NUP210 Gene

NURSA nuclear receptor signaling pathways regulating expression of NUP210 Gene:


SOURCE GeneReport for Unigene cluster for NUP210 Gene:


mRNA Expression by UniProt/SwissProt for NUP210 Gene:

Tissue specificity: Ubiquitous expression, with highest levels in lung, liver, pancreas, testis, and ovary, intermediate levels in brain, kidney, and spleen, and lowest levels in heart and skeletal muscle.

Evidence on tissue expression from TISSUES for NUP210 Gene

  • Liver(4.6)
  • Nervous system(4.6)
  • Lung(4.3)
  • Spleen(4.2)
  • Intestine(2.8)
  • Eye(2)
genes like me logo Genes that share expression patterns with NUP210: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NUP210 Gene

Orthologs for NUP210 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUP210 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NUP210 33 34
  • 99.06 (n)
(Canis familiaris)
Mammalia NUP210 33 34
  • 86.06 (n)
(Bos Taurus)
Mammalia NUP210 33 34
  • 84.38 (n)
(Mus musculus)
Mammalia Nup210 33 16 34
  • 83.15 (n)
(Rattus norvegicus)
Mammalia Nup210 33
  • 82.56 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 82 (a)
-- 34
  • 73 (a)
-- 34
  • 60 (a)
(Monodelphis domestica)
Mammalia NUP210 34
  • 78 (a)
(Gallus gallus)
Aves NUP210 33 34
  • 68.39 (n)
(Anolis carolinensis)
Reptilia NUP210 34
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nup210 33
  • 64.62 (n)
(Danio rerio)
Actinopterygii nup210 33 34
  • 63.61 (n)
fruit fly
(Drosophila melanogaster)
Insecta gp210 33 34
  • 43.12 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006280 33
  • 42.61 (n)
(Caenorhabditis elegans)
Secernentea npp-12 33 34
  • 40.08 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
Species where no ortholog for NUP210 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUP210 Gene

Gene Tree for NUP210 (if available)
Gene Tree for NUP210 (if available)

Paralogs for NUP210 Gene

Paralogs for NUP210 Gene

(1) SIMAP similar genes for NUP210 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NUP210: view

Variants for NUP210 Gene

Sequence variations from dbSNP and Humsavar for NUP210 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000046014 -- 13,387,690(+) GGCAC(C/T)GGTTG intron-variant
rs1000054 -- 13,390,641(-) AGCTC(C/T)GGGAG intron-variant
rs1000110635 -- 13,351,068(+) GATTT(A/T)AACTG intron-variant
rs1000143795 -- 13,413,471(+) TCTCA(A/G)AAAAA intron-variant
rs1000160024 -- 13,330,316(+) ACCTA(A/G)GACCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUP210 Gene

Variant ID Type Subtype PubMed ID
nsv955315 CNV deletion 24416366
nsv589740 CNV loss 21841781
nsv3706 CNV insertion 18451855
esv3425589 CNV duplication 20981092
esv3366661 CNV insertion 20981092
esv2724941 CNV deletion 23290073

Variation tolerance for NUP210 Gene

Residual Variation Intolerance Score: 58.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.92; 67.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUP210 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUP210 Gene

Disorders for NUP210 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NUP210 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
primary biliary cirrhosis
  • biliary liver cirrhosis
autoimmune disease of urogenital tract
cholangitis, primary sclerosing
  • primary sclerosing cholangitis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NUP210

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NUP210: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUP210 Gene

Publications for NUP210 Gene

  1. A major glycoprotein of the nuclear pore complex is a membrane-spanning polypeptide with a large lumenal domain and a small cytoplasmic tail. (PMID: 2184032) Greber UF … Gerace L (The EMBO journal 1990) 2 3 22 60
  2. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M … Yamada Y (American journal of hypertension 2010) 3 45 60
  3. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T … Yamada Y (International journal of molecular medicine 2010) 3 45 60
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  5. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 3 4 60

Products for NUP210 Gene

Sources for NUP210 Gene

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