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Aliases for NUP210 Gene

Aliases for NUP210 Gene

  • Nucleoporin 210kDa 2 3
  • Nuclear Envelope Pore Membrane Protein POM 210 3 4
  • Pore Membrane Protein Of 210 KDa 3 4
  • Nuclear Pore Protein Gp210 3 4
  • Nucleoporin Nup210 3 4
  • KIAA0906 4 6
  • POM210 3 4
  • GP210 3 6
  • Nuclear Pore Membrane Glycoprotein 210 3

External Ids for NUP210 Gene

Previous GeneCards Identifiers for NUP210 Gene

  • GC03U990118
  • GC03M013297
  • GC03M013332
  • GC03M013420
  • GC03M013548

Summaries for NUP210 Gene

Entrez Gene Summary for NUP210 Gene

  • The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a membrane-spanning glycoprotein that is a major component of the nuclear pore complex. Multiple pseudogenes related to this gene are located on chromosome 3. [provided by RefSeq, Jul 2013]

GeneCards Summary for NUP210 Gene

NUP210 (Nucleoporin 210kDa) is a Protein Coding gene. Among its related pathways are Disease and Cell Cycle, Mitotic. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is NUP210L.

UniProtKB/Swiss-Prot for NUP210 Gene

  • Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP210 Gene

Genomics for NUP210 Gene

Regulatory Elements for NUP210 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NUP210 Gene

Start:
13,316,230 bp from pter
End:
13,420,319 bp from pter
Size:
104,090 bases
Orientation:
Minus strand

Genomic View for NUP210 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUP210 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP210 Gene

Proteins for NUP210 Gene

  • Protein details for NUP210 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TEM1-PO210_HUMAN
    Recommended name:
    Nuclear pore membrane glycoprotein 210
    Protein Accession:
    Q8TEM1
    Secondary Accessions:
    • A6NN56
    • O94980
    • Q6NXG6
    • Q8NBJ1
    • Q9H6C8
    • Q9UFP3

    Protein attributes for NUP210 Gene

    Size:
    1887 amino acids
    Molecular mass:
    205111 Da
    Quaternary structure:
    • Forms dimers and possibly higher-order oligomers.
    Miscellaneous:
    • Knockdown of NUP210 causes nuclear membranes to accumulate aberrant structures termed twinned and fusion-arrested membranes and nuclear pore complex to cluster. Induces cell death and chromatin disruptions
    • Recognized by antinuclear autoantibodies in primary biliary cirrhosis
    SequenceCaution:
    • Sequence=BAB15332.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11688.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NUP210 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUP210 Gene

Proteomics data for NUP210 Gene at MOPED

Post-translational modifications for NUP210 Gene

  • N-glycosylated, but not all potential glycosylation sites may be used. Contains high-mannose type oligosaccharides (By similarity).
  • Phosphorylated at Ser-1881 in mitosis specifically; not phosphorylated in interphase.
  • Ubiquitination at Lys32, Lys79, Lys201, Lys212, Lys228, Lys774, Lys1020, Lys1063, Lys1258, Lys1576, Lys1724, and Lys1872
  • Glycosylation at Asn44, Asn337, Asn405, Asn484, Asn681, Asn801, Asn926, Asn1039, Asn1116, Asn1135, Asn1362, and Asn1441
  • Modification sites at PhosphoSitePlus

Other Protein References for NUP210 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NUP210 Gene

Domains for NUP210 Gene

Protein Domains for NUP210 Gene

Suggested Antigen Peptide Sequences for NUP210 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TEM1

UniProtKB/Swiss-Prot:

PO210_HUMAN :
  • Q8TEM1
Family:
  • Belongs to the NUP210 family.
genes like me logo Genes that share domains with NUP210: view

No data available for Gene Families for NUP210 Gene

Function for NUP210 Gene

Molecular function for NUP210 Gene

UniProtKB/Swiss-Prot Function: Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity.

Gene Ontology (GO) - Molecular Function for NUP210 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with NUP210: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NUP210

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NUP210 Gene

Localization for NUP210 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP210 Gene

Nucleus, nuclear pore complex. Nucleus membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUP210 Gene COMPARTMENTS Subcellular localization image for NUP210 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for NUP210 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope TAS --
GO:0005643 nuclear pore IEA --
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with NUP210: view

Pathways for NUP210 Gene

SuperPathways for NUP210 Gene

genes like me logo Genes that share pathways with NUP210: view

Pathways by source for NUP210 Gene

42 Reactome pathways for NUP210 Gene
1 KEGG pathway for NUP210 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for NUP210 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0005975 carbohydrate metabolic process TAS --
GO:0007077 mitotic nuclear envelope disassembly TAS --
GO:0008645 hexose transport TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with NUP210: view

Transcripts for NUP210 Gene

Unigene Clusters for NUP210 Gene

Nucleoporin 210kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NUP210

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NUP210

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUP210 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b ^
SP1: - - -
SP2:
SP3:
SP4:

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35a · 35b ^ 36a · 36b ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42
SP1: -
SP2:
SP3:
SP4:

Relevant External Links for NUP210 Gene

GeneLoc Exon Structure for
NUP210
ECgene alternative splicing isoforms for
NUP210

Expression for NUP210 Gene

mRNA expression in normal human tissues for NUP210 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NUP210 Gene

This gene is overexpressed in Whole Blood (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUP210 Gene

SOURCE GeneReport for Unigene cluster for NUP210 Gene Hs.475525

mRNA Expression by UniProt/SwissProt for NUP210 Gene

Q8TEM1-PO210_HUMAN
Tissue specificity: Ubiquitous expression, with highest levels in lung, liver, pancreas, testis, and ovary, intermediate levels in brain, kidney, and spleen, and lowest levels in heart and skeletal muscle.
genes like me logo Genes that share expressions with NUP210: view

In Situ Assay Products

Orthologs for NUP210 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUP210 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUP210 35
  • 99.06 (n)
  • 98.89 (a)
NUP210 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NUP210 35
  • 84.38 (n)
  • 84.29 (a)
NUP210 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUP210 35
  • 86.06 (n)
  • 86.7 (a)
NUP210 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nup210 35
  • 83.15 (n)
  • 85.16 (a)
Nup210 16
Nup210 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NUP210 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 60 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nup210 35
  • 82.56 (n)
  • 84.41 (a)
chicken
(Gallus gallus)
Aves NUP210 35
  • 68.39 (n)
  • 73.59 (a)
NUP210 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUP210 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nup210 35
  • 64.62 (n)
  • 62 (a)
zebrafish
(Danio rerio)
Actinopterygii nup210 35
  • 63.61 (n)
  • 62.16 (a)
nup210 36
  • 61 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006280 35
  • 42.61 (n)
  • 27.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta gp210 35
  • 43.12 (n)
  • 29.3 (a)
gp210 36
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea npp-12 35
  • 40.08 (n)
  • 29.33 (a)
npp-12 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for NUP210:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUP210 Gene

ENSEMBL:
Gene Tree for NUP210 (if available)
TreeFam:
Gene Tree for NUP210 (if available)

Paralogs for NUP210 Gene

Paralogs for NUP210 Gene

Selected SIMAP similar genes for NUP210 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for NUP210 Gene

genes like me logo Genes that share paralogs with NUP210: view

Variants for NUP210 Gene

Sequence variations from dbSNP and Humsavar for NUP210 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs93697 -- 13,318,788(+) AGCAA(G/T)TGGGC intron-variant
rs181351 -- 13,318,906(+) CCCCT(C/G)TGCCC intron-variant
rs184930 -- 13,319,013(+) TCCCC(C/T)AGGGC intron-variant
rs187129 -- 13,318,664(+) GTTAG(A/C)CCATT intron-variant
rs241755 -- 13,317,883(+) GGACA(C/T)TCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUP210 Gene

Variant ID Type Subtype PubMed ID
nsv876549 CNV Loss 21882294
nsv876550 CNV Loss 21882294
nsv3706 CNV Insertion 18451855
esv2724941 CNV Deletion 23290073
nsv876551 CNV Gain 21882294

Relevant External Links for NUP210 Gene

HapMap Linkage Disequilibrium report
NUP210
Human Gene Mutation Database (HGMD)
NUP210

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUP210 Gene

Disorders for NUP210 Gene

Relevant External Links for NUP210

Genetic Association Database (GAD)
NUP210
Human Genome Epidemiology (HuGE) Navigator
NUP210
genes like me logo Genes that share disorders with NUP210: view

No data available for UniProtKB/Swiss-Prot for NUP210 Gene

Publications for NUP210 Gene

  1. A major glycoprotein of the nuclear pore complex is a membrane-spanning polypeptide with a large lumenal domain and a small cytoplasmic tail. (PMID: 2184032) Greber U.F. … Gerace L. (EMBO J. 1990) 2 3 23
  2. Cell cycle-dependent phosphorylation of nucleoporins and nuclear pore membrane protein Gp210. (PMID: 8672508) Favreau C. … Courvalin J.C. (Biochemistry 1996) 3 23
  3. Antibody titer to gp210-C terminal peptide as a clinical parameter for monitoring primary biliary cirrhosis. (PMID: 15710222) Nakamura M. … Ishibashi H. (J. Hepatol. 2005) 3 23
  4. The 210-kD nuclear envelope polypeptide recognized by human autoantibodies in primary biliary cirrhosis is the major glycoprotein of the nuclear pore. (PMID: 2195063) Courvalin J.-C. … Wozniak R.W. (J. Clin. Invest. 1990) 3 4
  5. Autoantibodies from patients with primary biliary cirrhosis recognize a restricted region within the cytoplasmic tail of nuclear pore membrane glycoprotein Gp210. (PMID: 7504063) Nickowitz R.E. … Worman H.J. (J. Exp. Med. 1993) 2 3

Products for NUP210 Gene

Sources for NUP210 Gene

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