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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NUP210 Gene

protein-coding   GIFtS: 59
GCID: GC03M013420

Nucleoporin 210kDa

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nucleoporin 210kDa1 2     POM2102 3
Nuclear Envelope Pore Membrane Protein POM 2102 3     GP2102 5
Nuclear Pore Protein Gp2102 3     KIAA09063 5
Nucleoporin Nup2102 3     Nuclear Pore Membrane Glycoprotein 2102
Pore Membrane Protein Of 210 KDa2 3     

External Ids:    HGNC: 300521   Entrez Gene: 232252   Ensembl: ENSG000001321827   OMIM: 6077035   UniProtKB: Q8TEM13   

Export aliases for NUP210 gene to outside databases

Previous GC identifers: GC03U990118 GC03M013297 GC03M013332


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NUP210 Gene:
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that
regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components
of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a membrane-spanning
glycoprotein that is a major component of the nuclear pore complex. Multiple pseudogenes related to this gene are
located on chromosome 3. (provided by RefSeq, Jul 2013)

GeneCards Summary for NUP210 Gene: 
NUP210 (nucleoporin 210kDa) is a protein-coding gene. Diseases associated with NUP210 include primary biliary cirrhosis, and influenza, and among its related super-pathways are Interactions of Rev with host cellular proteins and HIV Life Cycle. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is NUP210L.

UniProtKB/Swiss-Prot: PO210_HUMAN, Q8TEM1
Function: Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural
integrity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NUP210 gene promoter:
         RP58   Lmo2   HSF1 (long)   Nkx5-1   E47   GATA-1   AREB6   HEN1   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNUP210 promoter sequence
   Search SABiosciences Chromatin IP Primers for NUP210

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUP210


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.1   Ensembl cytogenetic band:  3p25.1   HGNC cytogenetic band: 3p25

NUP210 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUP210 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M013420:  view genomic region     (about GC identifiers)

Start:
13,357,737 bp from pter      End:
13,461,809 bp from pter
Size:
104,073 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PO210_HUMAN, Q8TEM1 (See protein sequence)
Recommended Name: Nuclear pore membrane glycoprotein 210 precursor  
Size: 1887 amino acids; 205111 Da
Subunit: Forms dimers and possibly higher-order oligomers (By similarity)
Subcellular location: Nucleus, nuclear pore complex. Nucleus membrane; Single-pass type I membrane protein.
Endoplasmic reticulum membrane; Single-pass type I membrane protein
Miscellaneous: Recognized by antinuclear autoantibodies in primary biliary cirrhosis
Miscellaneous: Knockdown of NUP210 causes nuclear membranes to accumulate aberrant structures termed twinned and
fusion-arrested membranes and nuclear pore complex to cluster. Induces cell death and chromatin disruptions
Sequence caution: Sequence=BAB15332.1; Type=Erroneous initiation; Sequence=BAC11688.1; Type=Erroneous initiation;
Secondary accessions: A6NN56 O94980 Q6NXG6 Q8NBJ1 Q9H6C8 Q9UFP3
Alternative splicing: 2 isoforms:  Q8TEM1-1   Q8TEM1-2   

Explore the universe of human proteins at neXtProt for NUP210: NX_Q8TEM1

Explore proteomics data for NUP210 at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated, but not all potential glycosylation sites may be used. Contains high-mannose type oligosaccharides
    (By similarity)
  • UniProtKB: Phosphorylated at Ser-1881 in mitosis specifically; not phosphorylated in interphase (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TEM1

  • NUP210 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NUP210 Protein Expression
    REFSEQ proteins: NP_079199.2  
    ENSEMBL proteins: 
     ENSP00000254508  
    Reactome Protein details: Q8TEM1
    Human Recombinant Protein Products for NUP210: 
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    Novus Biologicals NUP210 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NUP210 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope TAS--
    GO:0005643nuclear pore IEA--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016020membrane ----
    GO:0031965nuclear membrane IEA--

    NUP210 for ontologies           About GeneDecksing



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    Assay Products for NUP210: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR003343 Big_2
     IPR008964 Invasin/intimin_cell_adhesion

    Graphical View of Domain Structure for InterPro Entry Q8TEM1

    ProtoNet protein and cluster: Q8TEM1

    1 Blocks protein domain: IPB003343 Bacterial Ig-like

    UniProtKB/Swiss-Prot: PO210_HUMAN, Q8TEM1
    Similarity: Belongs to the NUP210 family


    NUP210 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PO210_HUMAN, Q8TEM1
    Function: Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural
    integrity

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding ----
    GO:0046983protein dimerization activity IEA--
         
    NUP210 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NUP210 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NUP210

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NUP210 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NUP210 

    miRNA
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    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate NUP210 (see all 31):
    hsa-miR-125a-5p hsa-miR-4328 hsa-miR-15a hsa-miR-513a-5p hsa-miR-128 hsa-miR-766 hsa-miR-1297 hsa-miR-223
    SwitchGear 3'UTR luciferase reporter plasmidNUP210 3' UTR sequence
    Inhib. RNA
    Products:
        
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    GenScript: all cDNA clones in your preferred vector: NUP210 (NM_024923)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUP210


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NUP210 About   (see all 11)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Regulation of Glucokinase by Glucokinase Regulatory Protein
    Rev-mediated nuclear export of HIV RNA0.94
    Hexose transport0.87
    Nuclear import of Rev protein0.94
    Regulation of Glucokinase by Glucokinase Regulatory Protein0.82
    Interactions of Rev with host cellular proteins0.94
    Nuclear Pore Complex (NPC) Disassembly0.77
    Vpr-mediated nuclear import of PICs0.91
    Nuclear Envelope Breakdown0.77
    2HIV Life Cycle
    HIV Life Cycle0.92
    HIV Infection0.61
    Late Phase of HIV Life Cycle0.92
    Host Interactions of HIV factors0.60
    3Interferon Signaling
    Interferon Signaling0.61
    Antiviral mechanism by IFN-stimulated genes0.42
    Cytokine Signaling in Immune system0.61
    ISG15 antiviral mechanism0.42
    4M Phase
    M Phase0.88
    Mitotic M-M/G1 phases0.88
    5Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/29        Reactome Pathways for NUP210 (see all 29)
        Antiviral mechanism by IFN-stimulated genes
    Late Phase of HIV Life Cycle
    Metabolism
    Cell Cycle
    M Phase


    1         Kegg Pathway  (Kegg details for NUP210):
        RNA transport


    NUP210 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NUP210

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/84 Interacting proteins for NUP210 (Q8TEM13 ENSP000002545084) via UniProtKB, MINT, STRING, and/or I2D (see all 84)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EXOSC5Q9NQT43, ENSP000002212334I2D: score=4 STRING: ENSP00000221233
    TRIP6Q156543, ENSP000002004574I2D: score=2 STRING: ENSP00000200457
    CDK1P064933I2D: score=2 
    ATG14Q6ZNE53I2D: score=1 
    ATG2AQ2TAZ03I2D: score=1 
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0007077mitotic nuclear envelope disassembly TAS--
    GO:0008645hexose transport TAS--
    GO:0010827regulation of glucose transport TAS--

    NUP210 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NUP210 (PO210)

    Search CenterWatch for drugs/clinical trials and news about NUP210 / PO210

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NUP210 gene: 
    NM_024923.3  

    Unigene Cluster for NUP210:

    Nucleoporin 210kDa
    Hs.475525  [show with all ESTs]
    Unigene Representative Sequence: NM_024923
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000254508(uc003bxv.1) ENST00000485755 ENST00000479519(uc003bxw.3)
    ENST00000420141(uc003bxx.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NUP210
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate NUP210 (see all 31):
    hsa-miR-125a-5p hsa-miR-4328 hsa-miR-15a hsa-miR-513a-5p hsa-miR-128 hsa-miR-766 hsa-miR-1297 hsa-miR-223
    SwitchGear 3'UTR luciferase reporter plasmidNUP210 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NUP210
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUP210
    Clone
    Products:
         
    OriGene clones in human, mouse for NUP210 (see all 6)
    OriGene ORF clones in mouse, rat for NUP210
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NUP210 (NM_024923)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUP210
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUP210
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for NUP210
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUP210
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUP210

    Additional mRNA sequence: 

    AB020713.1 AK026042.1 AK074101.1 AK075545.1 AK225409.1 AL117527.1 BC020573.1 BC067089.1 
    BC068109.1 

    12 DOTS entries:

    DT.101960732  DT.452801  DT.403002  DT.95250157  DT.100781092  DT.100759786  DT.120888581  DT.40226159 
    DT.91773402  DT.99966218  DT.95250367  DT.99932807 

    24/432 AceView cDNA sequences (see all 432):

    AI912716 AW166144 AI300921 BM669587 BU076315 AI050870 AI299545 AI348602 
    T99718 AA789129 BE220406 AI342752 BU543083 AI690287 AI300623 AW006390 
    BX114540 AI302027 AL039259 BQ920567 AA652891 AW574552 BF433382 BU850250 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for NUP210    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b ^
    SP1:                                                                                                                                -     -     -               
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            

    ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35a · 35b ^ 36a · 36b ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42
    SP1:                                                                    -                                                         
    SP2:                                                                                                                              
    SP3:                                                                                                                              
    SP4:                                                                                                                              


    ECgene alternative splicing isoforms for NUP210

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NUP210 expression in normal human tissues (normalized intensities)      NUP210 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGTTGATTT
    NUP210 Expression
    About this image


    NUP210 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Bone Marrow CD105+ Cells   
             cd8+ t cell   
     
     Blood Brain Barrier (Nervous System)
             Postnatal Endothelial Cells Blood Brain Barrier
     
     Inner Cell Mass (Early Embryonic Tissues)
             Sox17-GFP genetically modified stem cells
     
     Bone (Muscoskeletal System)
             Chondrocytes Zeugopod Epiphyseal End
     
     Neural Tube (Nervous System)
             Telencephalon

    See NUP210 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NUP210

    SOURCE GeneReport for Unigene cluster: Hs.475525

    UniProtKB/Swiss-Prot: PO210_HUMAN, Q8TEM1
    Tissue specificity: Ubiquitous expression, with highest levels in lung, liver, pancreas, testis, and ovary,
    intermediate levels in brain, kidney, and spleen, and lowest levels in heart and skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Array including NUP210: 
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUP210
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUP210

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NUP210 gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nup2101 , 5 nucleoporin 2101, 5 83.05(n)1
    84.91(a)1
      6 (40.30 cM)5
    545631  NM_018815.21  NP_061285.21 
     910130685 
    chicken
    (Gallus gallus)
    Aves NUP2101 nucleoporin 210kDa 68.28(n)
    73.44(a)
      415977  XM_414320.3  XP_414320.2 
    lizard
    (Anolis carolinensis)
    Reptilia NUP2106
    nucleoporin 210kDa
    61(a)
    1 ↔ 1
    3(95603733-95769860)
    zebrafish
    (Danio rerio)
    Actinopterygii nup2101 nucleoporin 210 63.51(n)
    61.92(a)
      570945  XM_002667560.2  XP_002667606.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta gp2101 CG7897-PA 43.15(n)
    28.95(a)
      35512  NM_136340.2  NP_610184.2 
    worm
    (Caenorhabditis elegans)
    Secernentea npp-121 Protein NPP-12 39.13(n)
    28.15(a)
      172348  NM_059454.2  NP_491855.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons EMB30121 protein embryo defective 3012 38.58(n)
    25.53(a)
      834046  NM_123412.3  NP_198864.2 
    rice
    (Oryza sativa)
    Liliopsida Os09g05655001 hypothetical protein   --   4347873  NM_001070483.1  NP_001063948.1 


    ENSEMBL Gene Tree for NUP210 (if available)
    TreeFam Gene Tree for NUP210 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NUP210 gene
    NUP210L2  
    2 SIMAP similar genes for NUP210 using alignment to 1 protein entry:     PO210_HUMAN:
    NUP210L    DKFZp434E2118

    NUP210 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for NUP210
    PGOHUM00000237538 PGOHUM00000237765 PGOHUM00000237936 PGOHUM00000250302


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2490 SNPs in NUP210 are shown (see all 2490)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1468711061,2
    Cuntested113399818(+) CAGACA/C/GAACTT 2 F syn11NA 4552
    rs1438200931,2
    C--13357271(+) AAAAC-/AAAAAA 1 -- ds50010--------
    rs2002877561,2
    C--13357278(+) AAAAA-/A/AA  
            
    CATTT
    1 -- ds50010--------
    rs1809632201,2
    --13357336(+) AAACAC/GAGAAC 1 -- ds50010--------
    rs1454141911,2
    --13357342(+) AGAACA/GAGAGT 1 -- ds50010--------
    rs1450124791,2
    --13357746(+) AATCAC/TATAGA 1 -- ut310--------
    rs1490728321,2
    --13357834(+) ACAATC/TCTTCC 1 -- ut310--------
    rs1422237901,2
    C--13357902(+) CTTGTA/GCGGGA 1 -- ut310--------
    rs1852493311,2
    --13357903(+) TTGTGC/TGGGAT 1 -- ut310--------
    rs1458845421,2
    C--13357912(+) ATCCCA/C/GTCATC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for NUP210 (13357737 - 13461809 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for NUP210:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2724941CNV Deletion23290073
    nsv3706CNV Insertion18451855
    nsv876550CNV Loss21882294
    nsv876549CNV Loss21882294
    nsv876551CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607703    OMIM disorders: --

    3 diseases for NUP210:    About MalaCards
    primary biliary cirrhosis    influenza    hepatitis


    NUP210 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NUP210
    Human Genome Epidemiology (HuGE) Navigator: NUP210 (3 documents)

    Export disorders for NUP210 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NUP210 gene, integrated from 9 sources (see all 54):
    (articles sorted by number of sources associating them with NUP210)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A major glycoprotein of the nuclear pore complex is a membrane-spanning polypeptide with a large lumenal domain and a small cytoplasmic tail. (PubMed id 2184032)1, 3, 9 Greber U.F....Gerace L. (1990)
    2. Assessment of a polymorphism of SDK1 with hypertensio n in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (2010)
    3. Association of genetic variants with hemorrhagic stro ke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)1, 2 Muzny D.M....Gibbs R.A. (2006)
    6. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Nuclear pore protein gp210 is essential for viability in HeLa cells and Caenorhabditis elegans. (PubMed id 14517331)1, 2 Cohen M.... Gruenbaum Y. (2003)
    10. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2 Nagase T....Ohara O. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23225 HGNC: 30052 AceView: NUP210 Ensembl:ENSG00000132182 euGenes: HUgn23225
    ECgene: NUP210 Kegg: 23225 H-InvDB: NUP210

    (According to HUGE)
    About This Section
    HUGE: KIAA0906

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NUP210 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NUP210 gene:
    Search GeneIP for patents involving NUP210

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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