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Aliases for NUP210 Gene

Aliases for NUP210 Gene

  • Nucleoporin 210kDa 2 3 5
  • Nuclear Envelope Pore Membrane Protein POM 210 3 4
  • Pore Membrane Protein Of 210 KDa 3 4
  • Nuclear Pore Protein Gp210 3 4
  • Nucleoporin Nup210 3 4
  • POM210 3 4
  • KIAA0906 4
  • GP210 3

External Ids for NUP210 Gene

Previous GeneCards Identifiers for NUP210 Gene

  • GC03U990118
  • GC03M013297
  • GC03M013332
  • GC03M013420
  • GC03M013548
  • GC03M013607
  • GC03M013634

Summaries for NUP210 Gene

Entrez Gene Summary for NUP210 Gene

  • The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a membrane-spanning glycoprotein that is a major component of the nuclear pore complex. Multiple pseudogenes related to this gene are located on chromosome 3. [provided by RefSeq, Jul 2013]

GeneCards Summary for NUP210 Gene

NUP210 (Nucleoporin 210kDa) is a Protein Coding gene. Diseases associated with NUP210 include Autoimmune Disease Of Urogenital Tract and Primary Biliary Cirrhosis. Among its related pathways are Cellular response to heat stress and Glycosaminoglycan metabolism. GO annotations related to this gene include calcium ion binding and protein dimerization activity. An important paralog of this gene is NUP210L.

UniProtKB/Swiss-Prot for NUP210 Gene

  • Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP210 Gene

Genomics for NUP210 Gene

Regulatory Elements for NUP210 Gene

Enhancers for NUP210 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NUP210 on UCSC Golden Path with GeneCards custom track

Promoters for NUP210 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NUP210 on UCSC Golden Path with GeneCards custom track

Genomic Location for NUP210 Gene

13,316,230 bp from pter
13,420,319 bp from pter
104,090 bases
Minus strand

Genomic View for NUP210 Gene

Genes around NUP210 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUP210 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUP210 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP210 Gene

Proteins for NUP210 Gene

  • Protein details for NUP210 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nuclear pore membrane glycoprotein 210
    Protein Accession:
    Secondary Accessions:
    • A6NN56
    • O94980
    • Q6NXG6
    • Q8NBJ1
    • Q9H6C8
    • Q9UFP3

    Protein attributes for NUP210 Gene

    1887 amino acids
    Molecular mass:
    205111 Da
    Quaternary structure:
    • Forms dimers and possibly higher-order oligomers.
    • Knockdown of NUP210 causes nuclear membranes to accumulate aberrant structures termed twinned and fusion-arrested membranes and nuclear pore complex to cluster. Induces cell death and chromatin disruptions.
    • Recognized by antinuclear autoantibodies in primary biliary cirrhosis.
    • Sequence=BAB15332.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11688.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NUP210 Gene


neXtProt entry for NUP210 Gene

Proteomics data for NUP210 Gene at MOPED

Post-translational modifications for NUP210 Gene

  • N-glycosylated, but not all potential glycosylation sites may be used. Contains high-mannose type oligosaccharides (By similarity).
  • Phosphorylated at Ser-1881 in mitosis specifically; not phosphorylated in interphase.
  • Ubiquitination at Lys 32, Lys 79, Lys 201, Lys 212, Lys 228, Lys 774, Lys 1020, Lys 1063, Lys 1258, Lys 1576, and Lys 1724
  • Glycosylation at Asn 44, Asn 337, Asn 405, Asn 484, Asn 681, Asn 801, Asn 926, Asn 1039, Asn 1116, Asn 1135, Asn 1362, and Asn 1441
  • Modification sites at PhosphoSitePlus

Other Protein References for NUP210 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for NUP210

No data available for DME Specific Peptides for NUP210 Gene

Domains & Families for NUP210 Gene

Gene Families for NUP210 Gene

Protein Domains for NUP210 Gene

Suggested Antigen Peptide Sequences for NUP210 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NUP210 family.
  • Belongs to the NUP210 family.
genes like me logo Genes that share domains with NUP210: view

Function for NUP210 Gene

Molecular function for NUP210 Gene

UniProtKB/Swiss-Prot Function:
Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity.
genes like me logo Genes that share phenotypes with NUP210: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUP210 Gene

Localization for NUP210 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP210 Gene

Nucleus, nuclear pore complex. Nucleus membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for NUP210 Gene COMPARTMENTS Subcellular localization image for NUP210 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 4
plasma membrane 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NUP210 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with NUP210: view

Pathways & Interactions for NUP210 Gene

SuperPathways for NUP210 Gene

Superpath Contained pathways
1 Regulation of Glucokinase by Glucokinase Regulatory Protein
2 Infectious disease
3 Cell Cycle, Mitotic
4 Mitotic Prophase
5 Influenza Viral RNA Transcription and Replication
genes like me logo Genes that share pathways with NUP210: view

Pathways by source for NUP210 Gene

Gene Ontology (GO) - Biological Process for NUP210 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0007077 mitotic nuclear envelope disassembly TAS --
GO:0008033 tRNA processing TAS --
GO:0008645 hexose transport TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with NUP210: view

No data available for SIGNOR curated interactions for NUP210 Gene

Drugs & Compounds for NUP210 Gene

No Compound Related Data Available

Transcripts for NUP210 Gene

Unigene Clusters for NUP210 Gene

Nucleoporin 210kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUP210 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b ^
SP1: - - -

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35a · 35b ^ 36a · 36b ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42
SP1: -

Relevant External Links for NUP210 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NUP210 Gene

mRNA expression in normal human tissues for NUP210 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NUP210 Gene

This gene is overexpressed in Whole Blood (x4.6).

Protein differential expression in normal tissues from HIPED for NUP210 Gene

This gene is overexpressed in Nasal epithelium (24.5), Peripheral blood mononuclear cells (9.4), and Tlymphocyte (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUP210 Gene

SOURCE GeneReport for Unigene cluster for NUP210 Gene Hs.475525

mRNA Expression by UniProt/SwissProt for NUP210 Gene

Tissue specificity: Ubiquitous expression, with highest levels in lung, liver, pancreas, testis, and ovary, intermediate levels in brain, kidney, and spleen, and lowest levels in heart and skeletal muscle.
genes like me logo Genes that share expression patterns with NUP210: view

Protein tissue co-expression partners for NUP210 Gene

Primer Products

Orthologs for NUP210 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUP210 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NUP210 35
  • 84.38 (n)
  • 84.29 (a)
NUP210 36
  • 84 (a)
(Canis familiaris)
Mammalia NUP210 35
  • 86.06 (n)
  • 86.7 (a)
NUP210 36
  • 85 (a)
(Mus musculus)
Mammalia Nup210 35
  • 83.15 (n)
  • 85.16 (a)
Nup210 16
Nup210 36
  • 84 (a)
(Pan troglodytes)
Mammalia NUP210 35
  • 99.06 (n)
  • 98.89 (a)
NUP210 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Nup210 35
  • 82.56 (n)
  • 84.41 (a)
(Monodelphis domestica)
Mammalia NUP210 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 60 (a)
-- 36
  • 73 (a)
-- 36
  • 82 (a)
(Gallus gallus)
Aves NUP210 35
  • 68.39 (n)
  • 73.59 (a)
NUP210 36
  • 73 (a)
(Anolis carolinensis)
Reptilia NUP210 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nup210 35
  • 64.62 (n)
  • 62 (a)
(Danio rerio)
Actinopterygii nup210 35
  • 63.61 (n)
  • 62.16 (a)
nup210 36
  • 61 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006280 35
  • 42.61 (n)
  • 27.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta gp210 35
  • 43.12 (n)
  • 29.3 (a)
gp210 36
  • 22 (a)
(Caenorhabditis elegans)
Secernentea npp-12 35
  • 40.08 (n)
  • 29.33 (a)
npp-12 36
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
Species with no ortholog for NUP210:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUP210 Gene

Gene Tree for NUP210 (if available)
Gene Tree for NUP210 (if available)

Paralogs for NUP210 Gene

Paralogs for NUP210 Gene

(1) SIMAP similar genes for NUP210 Gene using alignment to 1 proteins: Pseudogenes for NUP210 Gene

genes like me logo Genes that share paralogs with NUP210: view

Variants for NUP210 Gene

Sequence variations from dbSNP and Humsavar for NUP210 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs2280084 - 13,354,079(-) CCCCC(A/G/T)GCTGG reference, missense
rs354479 - 13,319,891(+) GGTCC(A/G)AGACG reference, missense
rs354478 - 13,319,787(+) ATCCA(C/T)CACAA reference, missense
rs7628051 - 13,379,650(+) CCGGG(C/T)TGGGT reference, missense
rs3732671 - 13,366,056(-) GCGGC(A/G)TCCGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NUP210 Gene

Variant ID Type Subtype PubMed ID
nsv876549 CNV Loss 21882294
nsv876550 CNV Loss 21882294
nsv3706 CNV Insertion 18451855
esv2724941 CNV Deletion 23290073
nsv876551 CNV Gain 21882294

Variation tolerance for NUP210 Gene

Residual Variation Intolerance Score: 58.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.92; 67.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUP210 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUP210 Gene

Disorders for NUP210 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NUP210 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
autoimmune disease of urogenital tract
primary biliary cirrhosis
  • biliary liver cirrhosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NUP210

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NUP210: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUP210 Gene

Publications for NUP210 Gene

  1. A major glycoprotein of the nuclear pore complex is a membrane-spanning polypeptide with a large lumenal domain and a small cytoplasmic tail. (PMID: 2184032) Greber U.F. … Gerace L. (EMBO J. 1990) 2 3 23 67
  2. Antibody titer to gp210-C terminal peptide as a clinical parameter for monitoring primary biliary cirrhosis. (PMID: 15710222) Nakamura M. … Ishibashi H. (J. Hepatol. 2005) 3 23
  3. Cell cycle-dependent phosphorylation of nucleoporins and nuclear pore membrane protein Gp210. (PMID: 8672508) Favreau C. … Courvalin J.C. (Biochemistry 1996) 3 23
  4. Autoantibodies from patients with primary biliary cirrhosis recognize a restricted region within the cytoplasmic tail of nuclear pore membrane glycoprotein Gp210. (PMID: 7504063) Nickowitz R.E. … Worman H.J. (J. Exp. Med. 1993) 2 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for NUP210 Gene

Sources for NUP210 Gene