Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NUP210 Gene

protein-coding GIFtS: 56
GCID: GC03M013332

nucleoporin 210kDa

Explore 4 diseases affiliated with
NUP210 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Nucleoporin 210kDa¹ ²		Nuclear Pore Protein Gp210² ³
POM210¹ ² ³		Nucleoporin Nup210² ³
GP210¹ ² ⁵		Pore Membrane Protein Of 210 KDa² ³
KIAA0906¹ ³ ⁵		FLJ22389¹
Nuclear Envelope Pore Membrane Protein POM 210² ³		Nuclear Pore Membrane Glycoprotein 210²

External Ids:	HGNC: 30052¹	Entrez Gene: 23225²	Ensembl: ENSG00000132182⁷	OMIM: 607703⁵	UniProtKB: Q8TEM1³

Export aliases for NUP210 gene to outside databases

Previous GC identifers: GC03U990118 GC03M013297

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NUP210:

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that

regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of

the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a membrane-spanning glycoprotein

that is a major component of the nuclear pore complex. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PO210_HUMAN, Q8TEM1

Function: Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural

integrity

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NUP210 gene promoter:
RP58 Lmo2 HSF1 (long) Nkx5-1 E47 GATA-1 AREB6 HEN1 HSF1short
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NUP210 promoter sequence

Search SABiosciences Chromatin IP Primers for NUP210

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUP210

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.1 Ensembl cytogenetic band: 3p25.1 HGNC cytogenetic band: 3p25

NUP210 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUP210 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M013332: view genomic region (about GC identifiers)

Start:	13,357,737 bp from pter	End:	13,461,809 bp from pter
Size:	104,073 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PO210_HUMAN, Q8TEM1 (See protein sequence)

Recommended Name: Nuclear pore membrane glycoprotein 210 precursor

Size: 1887 amino acids; 205111 Da

Subunit: Forms dimers and possibly higher-order oligomers (By similarity)

Subcellular location: Nucleus, nuclear pore complex. Nucleus membrane; Single-pass type I membrane protein. Endoplasmic

reticulum membrane; Single-pass type I membrane protein

Miscellaneous: Recognized by antinuclear autoantibodies in primary biliary cirrhosis

Miscellaneous: Knockdown of NUP210 causes nuclear membranes to accumulate aberrant structures termed twinned and

fusion-arrested membranes and nuclear pore complex to cluster. Induces cell death and chromatin disruptions

Sequence caution: Sequence=BAB15332.1; Type=Erroneous initiation; Sequence=BAC11688.1; Type=Erroneous initiation;

Secondary accessions: A6NN56 O94980 Q6NXG6 Q8NBJ1 Q9H6C8 Q9UFP3

Alternative splicing: 2 isoforms: Q8TEM1-1 Q8TEM1-2

Explore the universe of human proteins at neXtProt for NUP210: NX_Q8TEM1

Post-translational modifications:

N-glycosylated, but not all potential glycosylation sites may be used. Contains high-mannose type oligosaccharides (By

similarity)¹

Phosphorylated at Ser-1881 in mitosis specifically; not phosphorylated in interphase (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8TEM1

NUP210 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_079199.2

ENSEMBL proteins:

ENSP00000254508

Reactome Protein details: Q8TEM1
Human Recombinant Protein Products for NUP210:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: NUP210 Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for NUP210
	GenScript Custom Purified and Recombinant Proteins Services for NUP210
	Novus Biologicals NUP210 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NUP210

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005635	nuclear envelope	TAS	--
GO:0005643	nuclear pore	IEA	--
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0031965	nuclear membrane	IEA	--

NUP210 for ontologies About GeneDecksing

NUP210 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for NUP210
	GenScript Custom Superior Antibodies Services for NUP210
	Novus Biologicals NUP210 Antibody
	Abcam antibodies for NUP210
	Uscn Antibodies for NUP210
	ThermoFisher Antibodies for NUP210

Assay Products for NUP210:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NUP210
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NUP210

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NUP210 for domains About GeneDecksing

2 InterPro domains/families:

IPR003343 Big_2

IPR008964 Invasin/intimin_cell_adhesion

Graphical View of Domain Structure for InterPro Entry Q8TEM1

ProtoNet protein and cluster: Q8TEM1

1 Blocks protein family: IPB003343 Bacterial Ig-like

UniProtKB/Swiss-Prot: PO210_HUMAN, Q8TEM1

Similarity: Belongs to the NUP210 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PO210_HUMAN, Q8TEM1

Function: Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural

integrity

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0046983	protein dimerization activity	IEA	--

NUP210 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NUP210

miRNA Products:		OriGene 3'-UTR Clone: NUP210 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NUP210
		8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate NUP210 (see all 31):
		hsa-miR-125a-5p hsa-miR-4328 hsa-miR-15a hsa-miR-513a-5p hsa-miR-128 hsa-miR-766 hsa-miR-1297 hsa-miR-223

		SwitchGear 3'UTR luciferase reporter plasmid: NUP210 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NUP210 (see all 7) OriGene shRNA RFP: NUP210 OriGene siRNA: NUP210
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUP210
		Sirion Biotech Custom design and validation of potent shRNA sequences against NUP210

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for NUP210
			Sirion Biotech Customized adenovirus for overexpression of NUP210 Sirion Biotech Customized adenovirus for potent knockdown of NUP210

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUP210 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUP210 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NUP210 (NM_024923)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUP210
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUP210

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NUP210
		Search LifeMap BioReagents cell lines for NUP210
		Sirion Biotech Customized stable knockdown cell line services for NUP210 Sirion Biotech Customized inducible knockdown cell line services for NUP210

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUP210

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus

8/11 pathways (see all 11)
Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus	1.00	Interactions of Vpr with host cellular proteins	0.70
Nuclear import of Rev protein	0.76	Glucose transport	0.57
Vpr-mediated nuclear import of PICs	0.76	Hexose transport	0.55
Regulation of Glucokinase by Glucokinase Regulatory Protein	0.75	ISG15 antiviral mechanism	0.49

Cytokine Signaling in Immune system

Cytokine Signaling in Immune system

1.00

Interferon Signaling

0.61

HIV Infection

HIV Infection

1.00

Host Interactions of HIV factors

0.64

SLC-mediated transmembrane transport

SLC-mediated transmembrane transport

1.00

Transmembrane transport of small molecules

0.50

Late Phase of HIV Life Cycle

Late Phase of HIV Life Cycle

1.00

HIV Life Cycle

0.90

Pathway sources
See GeneCards unified pathways
Show all pathways

5/23 Reactome Pathways for NUP210 (see all 23)

	Antiviral mechanism by IFN-stimulated genes
	Late Phase of HIV Life Cycle
	Metabolism
	Interactions of Rev with host cellular proteins
	Disease

1 Kegg Pathway (Kegg details for NUP210):

RNA transport

NUP210 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NUP210

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/84 Interacting proteins for NUP210 (Q8TEM1³ ENSP00000254508⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 84)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EXOSC5	Q9NQT4³, ENSP00000221233⁴	I2D: score=4 STRING: ENSP00000221233
TRIP6	Q15654³, ENSP00000200457⁴	I2D: score=2 STRING: ENSP00000200457
CDK1	P06493³	I2D: score=2
ATG14	Q6ZNE5³	I2D: score=1
ATG2A	Q2TAZ0³	I2D: score=1

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005975	carbohydrate metabolic process	TAS	--
GO:0008645	hexose transport	TAS	--
GO:0010827	regulation of glucose transport	TAS	--
GO:0015031	protein transport	IEA	--
GO:0015758	glucose transport	TAS	--

NUP210 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NUP210
Search CenterWatch for drugs/clinical trials and news about NUP210 / PO210

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NUP210 gene:

NM_024923.2

Unigene Cluster for NUP210:

Nucleoporin 210kDa

Hs.475525 [show with all ESTs]

Unigene Representative Sequence: NM_024923

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000254508(uc003bxv.1) ENST00000485755 ENST00000479519(uc003bxw.3)

ENST00000420141(uc003bxx.3)

miRNA Products:		OriGene 3'-UTR Clone: NUP210 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NUP210
		8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate NUP210 (see all 31):
		hsa-miR-125a-5p hsa-miR-4328 hsa-miR-15a hsa-miR-513a-5p hsa-miR-128 hsa-miR-766 hsa-miR-1297 hsa-miR-223

		SwitchGear 3'UTR luciferase reporter plasmid: NUP210 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NUP210 (see all 7) OriGene shRNA RFP: NUP210 OriGene siRNA: NUP210
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUP210
		Sirion Biotech Custom design and validation of potent shRNA sequences against NUP210

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUP210 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUP210 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NUP210 (NM_024923)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUP210
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUP210

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUP210 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat NUP210
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUP210
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUP210

Additional cDNA sequence:

AB020713.1 AK026042.1 AK074101.1 AK075545.1 AK225409.1 AL117527.1 BC020573.1 BC067089.1

BC068109.1

12 DOTS entries:

DT.101960732 DT.452801 DT.403002 DT.95250157 DT.100781092 DT.100759786 DT.120888581 DT.40226159

DT.91773402 DT.99966218 DT.95250367 DT.99932807

24/432 AceView cDNA sequences (see all 432):

NM_024923 AI268530 AI002329 BE467190 AI348362 AI703054 BF433728 BU931966

AI299477 CB178496 AI218744 AI023554 AA789129 AI050870 AI268346 BE550199

AI268398 BE502711 BX493065 AA446015 BQ706744 AI300921 AW166144 AI912716

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for NUP210 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16a	·	16b	^	17	^	18	^	19	^	20a	·	20b	^	21	^	22	^	23a	·	23b	^
SP1:																																											-		-		-
SP2:
SP3:
SP4:

ExUns:	24	^	25	^	26	^	27	^	28	^	29	^	30	^	31	^	32	^	33	^	34	^	35a	·	35b	^	36a	·	36b	^	37	^	38	^	39	^	40	^	41	^	42
SP1:																							-
SP2:
SP3:
SP4:

ECgene alternative splicing isoforms for NUP210

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NUP210 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGTTGATTT

About this image

NUP210 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Zeugopod Epiphyseal End

Chondrocytes

Bone, Cartilage

Brain

Blood Brain Barrier

Postnatal Endothelial Cells

Blood Brain Barrier, Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Sox17-GFP genetically modified stem cells (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

See NUP210 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NUP210

SOURCE GeneReport for Unigene cluster: Hs.475525

UniProtKB/Swiss-Prot: PO210_HUMAN, Q8TEM1

Tissue specificity: Ubiquitous expression, with highest levels in lung, liver, pancreas, testis, and ovary,

intermediate levels in brain, kidney, and spleen, and lowest levels in heart and skeletal muscle

SABiosciences Expression via Pathway-Focused PCR Array including NUP210:

Molecular Toxicology PathwayFinder 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUP210 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat NUP210
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUP210
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUP210

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUP210

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUP210 gene from 8/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Nup210^{1 , 5}	nucleoporin 210^{1, 5}	83.05(n)¹ 84.91(a)¹		6 (40.30 cM)⁵ 54563¹ NM_018815.2¹ NP_061285.2¹ 91013068⁵
chicken (Gallus gallus)	Aves	NUP210¹	nucleoporin 210kDa	68.28(n) 73.44(a)		415977 XM_414320.3 XP_414320.2
lizard (Anolis carolinensis)	Reptilia	NUP210⁶	--	64(a)	1 ↔ 1	3(95605455-95769392)
zebrafish (Danio rerio)	Actinopterygii	nup210¹	nucleoporin 210	63.51(n) 61.92(a)		570945 XM_002667560.2 XP_002667606.2
fruit fly (Drosophila melanogaster)	Insecta	gp210¹	CG7897-PA	43.15(n) 28.95(a)		35512 NM_136340.2 NP_610184.2
worm (Caenorhabditis elegans)	Secernentea	npp-12¹	Protein NPP-12	39.13(n) 28.15(a)		172348 NM_059454.2 NP_491855.1
thale cress (Arabidopsis thaliana)	eudicotyledons	EMB3012¹	protein embryo defective 3012	38.58(n) 25.53(a)		834046 NM_123412.3 NP_198864.2
rice (Oryza sativa)	Liliopsida	Os09g0565500¹	hypothetical protein	--		4347873 NM_001070483.1 NP_001063948.1

ENSEMBL Gene Tree for NUP210 (if available)
TreeFam Gene Tree for NUP210 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NUP210 gene

NUP210L²

2 SIMAP similar genes for NUP210 using alignment to 1 protein entry: PO210_HUMAN:

NUP210L DKFZp434E2118

NUP210 for paralogs About GeneDecksing

4 Pseudogenes.org Pseudogenes for NUP210
PGOHUM00000237538 PGOHUM00000237765 PGOHUM00000237936 PGOHUM00000250302

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs146871106^1,2	C	other	13399818(+)	`CAGACA/C/GAACTT`	3	F L	mis¹ syn¹		1		NA	4552
rs143820093^1,2	C	--	13357267(+)	`AAAAC-/AAAAAA`	1	--	ds500¹		0	--	--	--	--
rs180963220^1,2		--	13357336(+)	`AAACAC/GAGAAC`	1	--	ds500¹		0	--	--	--	--
rs145414191^1,2		--	13357342(+)	`AGAACA/GAGAGT`	1	--	ds500¹		0	--	--	--	--
rs145012479^1,2		--	13357746(+)	`AATCAC/TATAGA`	1	--	ut3¹		0	--	--	--	--
rs149072832^1,2		--	13357834(+)	`ACAATC/TCTTCC`	1	--	ut3¹		0	--	--	--	--
rs142223790^1,2		--	13357902(+)	`CTTGTA/GCGGGA`	1	--	ut3¹		0	--	--	--	--
rs185249331^1,2		--	13357903(+)	`TTGTGC/TGGGAT`	1	--	ut3¹		0	--	--	--	--
rs190402156^1,2		--	13357935(+)	`CACAGC/TGTCCA`	1	--	ut3¹		0	--	--	--	--
rs151232217^1,2		--	13357941(+)	`GTCCAA/CGCATG`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NUP210 (13357737 - 13461809 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NUP210: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NUP210

DNA2.0 Custom Variant and Variant Library Synthesis for NUP210

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NUP210 for disorders           About GeneDecksing

OMIM gene information: 607703    OMIM disorders: --

4 diseases for NUP210:    About MalaCards

primary biliary cirrhosis twinning myeloma hepatitis

Human Genome Epidemiology (HuGE) Navigator: NUP210 (3 documents)

Export disorders for NUP210 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NUP210 gene, integrated from 9 sources (see all 50):
(articles sorted by number of sources associating them with NUP210)

Utopia: connect your pdf to the dynamic
world of online information

A major glycoprotein of the nuclear pore complex is a membrane-spanning polypeptide with a large lumenal domain and a small cytoplasmic tail. (PubMed id 2184032)^{1, 3, 9} Greber U.F....Gerace L. (1990)
The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)^{1, 2} Muzny D.M....Gibbs R.A. (2006)
Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)^{1, 2} Otsuki T....Isogai T. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Nuclear pore protein gp210 is essential for viability in HeLa cells and Caenorhabditis elegans. (PubMed id 14517331)^{1, 2} Cohen M.... Gruenbaum Y. (2003)
Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)^{1, 2} Nagase T....Ohara O. (1998)
Autoantibodies from patients with primary biliary cir rhosis recognize a restricted region within the cytoplasmic tail of nuclear por e membrane glycoprotein Gp210. (PubMed id 7504063)^{1, 3} Nickowitz R.E. and Worman H.J. (1993)
The 210-kD nuclear envelope polypeptide recognized by human autoantibodies in primary biliary cirrhosis is the major glycoprotein of the nuclear pore. (PubMed id 2195063)^{1, 2} Courvalin J.-C.... Wozniak R.W. (1990)
Cell cycle-dependent phosphorylation of nucleoporins and nuclear pore membrane protein Gp210. (PubMed id 8672508)^{1, 9} Favreau C....Courvalin J.C. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 23225	HGNC: 30052	AceView: NUP210	Ensembl:ENSG00000132182	euGenes: HUgn23225
ECgene: NUP210	Kegg: 23225	H-InvDB: NUP210

(According to HUGE)
About This Section

HUGE: KIAA0906

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NUP210	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NUP210 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for NUP210 gene:
Search GeneIP for patents involving NUP210

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for NUP210
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NUP210		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUP210
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for NUP210		OriGene 3'-UTR Clone for NUP210
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUP210		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUP210
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for NUP210		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for NUP210		OriGene Custom Protein Services for NUP210
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NUP210
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NUP210
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUP210
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUP210
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUP210
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUP210

	GenScript Custom Purified and Recombinant Proteins Services for NUP210		GenScript cDNA clones with any tag delivered in your preferred vector for NUP210
	GenScript Custom Assay Services for NUP210		GenScript Custom Superior Antibodies Services for NUP210
	GenScript Custom overexpressing Cell Line Services for NUP210		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in NUP210 promoter
	Search Chromatin IP Primers for NUP210
	RT² qPCR Primer Assay in human, mouse, rat NUP210
	GNC Network for NUP210
	SABiosciences PCR Arrays including human, mouse, rat NUP210

Search Tocris compounds for NUP210

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	NUP210 antibodies
	NUP210 proteins

	Antibodies for NUP210
	See all of Abcam's Antibodies, Kits and Proteins for NUP210
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

NUP210 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for NUP210

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUP210

	SwitchGear 3'UTR luciferase reporter plasmids for NUP210
	SwitchGear Promoter luciferase reporter plasmids for NUP210

ThermoFisher Antibodies for NUP210

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUP210

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NUP210

Sirion Biotech Customized:

	stable knockdown cell line services for NUP210
	inducible knockdown cell line services for NUP210
	design and validation of potent shRNA sequences against NUP210
	adenovirus for potent knockdown of NUP210
	adenovirus for overexpression of NUP210
	stable overexpressing cell line services
	inducible overexpressing cell line services

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes NUP210 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

NUP210 Gene

nucleoporin 210kDa

Aliases
for NUP210 gene

Summaries
for NUP210 gene

Genomic Views
for NUP210 gene

Proteins
for NUP210 gene

Protein Domains /
Families
for NUP210 gene

Function
for NUP210 gene

Pathways & Interactions
for NUP210 gene

Drugs & Compounds
for NUP210 gene

Transcripts
for NUP210 gene

Expression
for NUP210 gene

Orthologs
for NUP210 gene

Paralogs
for NUP210 gene

Genomic Variants
for NUP210 gene

Disorders / Diseases
for NUP210 gene

Publications
for NUP210 gene

External Searches for NUP210 gene

Genome Databases showing NUP210 gene

Other Databases showing NUP210 gene

Specialized Databases showing NUP210 gene

Intellectual Property
for NUP210 gene

Products
for NUP210 gene

View Random Gene

Advanced Search

Export list of displayed genes

NUP210 Gene

nucleoporin 210kDa

Aliasesfor NUP210 gene

Summariesfor NUP210 gene

Genomic Viewsfor NUP210 gene

Proteinsfor NUP210 gene

Protein Domains /Familiesfor NUP210 gene

Functionfor NUP210 gene

Pathways & Interactionsfor NUP210 gene

Drugs & Compoundsfor NUP210 gene

Transcriptsfor NUP210 gene

Expression for NUP210 gene

Orthologsfor NUP210 gene

Paralogsfor NUP210 gene

Genomic Variantsfor NUP210 gene

Disorders / Diseasesfor NUP210 gene

Publicationsfor NUP210 gene

External Searches for NUP210 gene

Genome Databases showing NUP210 gene

Other Databases showing NUP210 gene

Specialized Databases showing NUP210 gene

Intellectual Propertyfor NUP210 gene

Productsfor NUP210 gene

View Random Gene

Aliases
for NUP210 gene

Summaries
for NUP210 gene

Genomic Views
for NUP210 gene

Proteins
for NUP210 gene

Protein Domains /
Families
for NUP210 gene

Function
for NUP210 gene

Pathways & Interactions
for NUP210 gene

Drugs & Compounds
for NUP210 gene

Transcripts
for NUP210 gene

Expression
for NUP210 gene

Orthologs
for NUP210 gene

Paralogs
for NUP210 gene

Genomic Variants
for NUP210 gene

Disorders / Diseases
for NUP210 gene

Publications
for NUP210 gene

Intellectual Property
for NUP210 gene

Products
for NUP210 gene