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Aliases for NUP205 Gene

Aliases for NUP205 Gene

  • Nucleoporin 205kDa 2 3
  • 205 KDa Nucleoporin 3 4
  • Nucleoporin Nup205 3 4
  • C7orf14 3 4
  • Chromosome 7 Open Reading Frame 14 2
  • KIAA0225 4

External Ids for NUP205 Gene

Previous HGNC Symbols for NUP205 Gene

  • C7orf14

Previous GeneCards Identifiers for NUP205 Gene

  • GC07P134659
  • GC07P134660
  • GC07P134699
  • GC07P134893
  • GC07P135242
  • GC07P129545

Summaries for NUP205 Gene

GeneCards Summary for NUP205 Gene

NUP205 (Nucleoporin 205kDa) is a Protein Coding gene. Diseases associated with NUP205 include paget's disease of bone. Among its related pathways are Immune System and Infectious disease. GO annotations related to this gene include structural constituent of nuclear pore.

UniProtKB/Swiss-Prot for NUP205 Gene

  • Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor NUP62 and other nucleoporins, but not NUP153 and TPR, to the NPC.

Gene Wiki entry for NUP205 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP205 Gene

Genomics for NUP205 Gene

Regulatory Elements for NUP205 Gene

Genomic Location for NUP205 Gene

Chromosome:
7
Start:
135,557,914 bp from pter
End:
135,648,757 bp from pter
Size:
90,844 bases
Orientation:
Plus strand

Genomic View for NUP205 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUP205 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP205 Gene

Proteins for NUP205 Gene

  • Protein details for NUP205 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92621-NU205_HUMAN
    Recommended name:
    Nuclear pore complex protein Nup205
    Protein Accession:
    Q92621
    Secondary Accessions:
    • A6H8X3
    • Q86YC1

    Protein attributes for NUP205 Gene

    Size:
    2012 amino acids
    Molecular mass:
    227922 Da
    Quaternary structure:
    • Part of the nuclear pore complex (NPC). Forms a complex with NUP53, NUP93, NUP155 and lamin B. Does not interact with TPR.
    SequenceCaution:
    • Sequence=BAA13214.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for NUP205 Gene

Proteomics data for NUP205 Gene at MOPED

Post-translational modifications for NUP205 Gene

  • Ubiquitination at Lys 23, Lys 41, Lys 69, Lys 156, Lys 304, Lys 321, Lys 496, Lys 571, Lys 648, Lys 918, Lys 1150, Lys 1177, Lys 1219, Lys 1461, Lys 1732, and Lys 1988
  • Modification sites at PhosphoSitePlus

Other Protein References for NUP205 Gene

No data available for DME Specific Peptides for NUP205 Gene

Domains & Families for NUP205 Gene

Gene Families for NUP205 Gene

Protein Domains for NUP205 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NUP205 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NUP205: view

No data available for UniProtKB/Swiss-Prot for NUP205 Gene

Function for NUP205 Gene

Molecular function for NUP205 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor NUP62 and other nucleoporins, but not NUP153 and TPR, to the NPC.

Gene Ontology (GO) - Molecular Function for NUP205 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9348540
GO:0017056 structural constituent of nuclear pore IMP 15229283
genes like me logo Genes that share ontologies with NUP205: view
genes like me logo Genes that share phenotypes with NUP205: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NUP205

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for NUP205 Gene

Localization for NUP205 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP205 Gene

Nucleus membrane; Peripheral membrane protein. Nucleus, nuclear pore complex. Note=Localized near the center, on both the cytoplasmic and nuclear side, of the NPC core structure.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUP205 Gene COMPARTMENTS Subcellular localization image for NUP205 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for NUP205 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope TAS --
GO:0005643 nuclear pore NAS 9348540
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with NUP205: view

Pathways & Interactions for NUP205 Gene

SuperPathways for NUP205 Gene

Superpath Contained pathways
1 Transport of Ribonucleoproteins into the Host Nucleus
2 Infectious disease
.53
3 Cell Cycle, Mitotic
.62
4 Mitotic Prophase
5 Influenza Viral RNA Transcription and Replication
genes like me logo Genes that share pathways with NUP205: view

Pathways by source for NUP205 Gene

1 KEGG pathway for NUP205 Gene

Gene Ontology (GO) - Biological Process for NUP205 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000059 protein import into nucleus, docking TAS 9348540
GO:0000278 mitotic cell cycle TAS --
GO:0005975 carbohydrate metabolic process TAS --
GO:0006913 nucleocytoplasmic transport TAS 9348540
GO:0007077 mitotic nuclear envelope disassembly TAS --
genes like me logo Genes that share ontologies with NUP205: view

No data available for SIGNOR curated interactions for NUP205 Gene

Drugs & Compounds for NUP205 Gene

No Compound Related Data Available

Transcripts for NUP205 Gene

Unigene Clusters for NUP205 Gene

Nucleoporin 205kDa:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NUP205

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUP205 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - -
SP2:
SP3:
SP4:

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41a · 41b ^ 42 ^ 43 ^ 44 ^ 45
SP1: -
SP2:
SP3:
SP4: -

Relevant External Links for NUP205 Gene

GeneLoc Exon Structure for
NUP205
ECgene alternative splicing isoforms for
NUP205

Expression for NUP205 Gene

mRNA expression in normal human tissues for NUP205 Gene

Protein differential expression in normal tissues from HIPED for NUP205 Gene

This gene is overexpressed in Nasal epithelium (10.5) and Bone (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUP205 Gene



SOURCE GeneReport for Unigene cluster for NUP205 Gene Hs.743250

genes like me logo Genes that share expression patterns with NUP205: view

Protein tissue co-expression partners for NUP205 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NUP205 Gene

Orthologs for NUP205 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUP205 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NUP205 35
  • 91.02 (n)
  • 96.32 (a)
NUP205 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUP205 35
  • 92.33 (n)
  • 96.61 (a)
NUP205 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nup205 35
  • 87.88 (n)
  • 93.57 (a)
Nup205 16
Nup205 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NUP205 35
  • 99.55 (n)
  • 99.7 (a)
NUP205 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nup205 35
  • 87.98 (n)
  • 94.52 (a)
oppossum
(Monodelphis domestica)
Mammalia NUP205 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 92 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
chicken
(Gallus gallus)
Aves NUP205 35
  • 78.71 (n)
  • 89.36 (a)
NUP205 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUP205 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nup205 35
  • 71.12 (n)
  • 78.96 (a)
Str.19120 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.13298 35
zebrafish
(Danio rerio)
Actinopterygii nup205 35
  • 66.14 (n)
  • 71.22 (a)
nup205 36
  • 70 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008090 35
  • 44.73 (n)
  • 34.04 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nup205 35
  • 42.77 (n)
  • 32.1 (a)
CG11943 36
  • 29 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea npp-3 36
  • 19 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G51200 35
  • 41.87 (n)
  • 27.67 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToOne
Species with no ortholog for NUP205:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUP205 Gene

ENSEMBL:
Gene Tree for NUP205 (if available)
TreeFam:
Gene Tree for NUP205 (if available)

Paralogs for NUP205 Gene

No data available for Paralogs for NUP205 Gene

Variants for NUP205 Gene

Sequence variations from dbSNP and Humsavar for NUP205 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1140667 -- 135,645,567(+) CTCGA(G/T)AACCT reference, missense
rs1140668 -- 135,645,588(+) CAGAA(G/T)ACTGC reference, missense
rs3800759 -- 135,637,552(+) ACAAA(A/C/T)GTGTC intron-variant
rs3800760 -- 135,637,916(+) AGATA(A/C/T)CTTTT intron-variant
rs3839678 -- 135,637,717(+) AAAAA(-/A)GGGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUP205 Gene

Variant ID Type Subtype PubMed ID
nsv520786 CNV Gain 19592680
nsv831146 CNV Loss 17160897
esv2659766 CNV Deletion 23128226
esv2485767 CNV Deletion 19546169
esv2288564 CNV Deletion 18987734
esv2675714 CNV Deletion 23128226
esv2735191 CNV Deletion 23290073

Variation tolerance for NUP205 Gene

Residual Variation Intolerance Score: 1.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.95; 67.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUP205 Gene

HapMap Linkage Disequilibrium report
NUP205

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUP205 Gene

Disorders for NUP205 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NUP205 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
paget's disease of bone
  • paget disease of bone
- elite association

Relevant External Links for NUP205

Genetic Association Database (GAD)
NUP205
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUP205
genes like me logo Genes that share disorders with NUP205: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUP205 Gene

Publications for NUP205 Gene

  1. Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex. (PMID: 15703211) Hawryluk-Gara L.A. … Wozniak R.W. (Mol. Biol. Cell 2005) 23 67
  2. Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket. (PMID: 15229283) Krull S. … Cordes V.C. (Mol. Biol. Cell 2004) 23 67
  3. Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assembly. (PMID: 9348540) Grandi P. … Hurt E. (Mol. Biol. Cell 1997) 2 67
  4. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 2 67
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67

Products for NUP205 Gene

Sources for NUP205 Gene

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