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Aliases for NUP188 Gene

Aliases for NUP188 Gene

  • Nucleoporin 188kDa 2 3 5
  • KIAA0169 2 3 4
  • HNup188 3 4

External Ids for NUP188 Gene

Previous HGNC Symbols for NUP188 Gene

  • KIAA0169

Previous GeneCards Identifiers for NUP188 Gene

  • GC09U900613
  • GC09P128789
  • GC09P130749
  • GC09P131709
  • GC09P101317

Summaries for NUP188 Gene

Entrez Gene Summary for NUP188 Gene

  • The nuclear pore complex (NPC) is found on the nuclear envelope and forms a gateway that regulates the flow of proteins and RNAs between the cytoplasm and nucleoplasm. The NPC is comprised of approximately 30 distinct proteins collectively known as nucleoporins. Nucleoporins are pore-complex-specific glycoproteins which often have cytoplasmically oriented O-linked N-acetylglucosamine residues and numerous repeats of the pentapeptide sequence XFXFG. However, the nucleoporin protein encoded by this gene does not contain the typical FG repeat sequences found in most vertebrate nucleoporins. This nucleoporin is thought to form part of the scaffold for the central channel of the nuclear pore. [provided by RefSeq, Jan 2013]

GeneCards Summary for NUP188 Gene

NUP188 (Nucleoporin 188kDa) is a Protein Coding gene. Among its related pathways are Cellular response to heat stress and Glycosaminoglycan metabolism. GO annotations related to this gene include binding. An important paralog of this gene is ENSG00000251184.

UniProtKB/Swiss-Prot for NUP188 Gene

  • May function as a component of the nuclear pore complex (NPC).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP188 Gene

Genomics for NUP188 Gene

Regulatory Elements for NUP188 Gene

Enhancers for NUP188 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NUP188 on UCSC Golden Path with GeneCards custom track

Promoters for NUP188 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NUP188 on UCSC Golden Path with GeneCards custom track

Genomic Location for NUP188 Gene

128,947,693 bp from pter
129,007,096 bp from pter
59,404 bases
Plus strand

Genomic View for NUP188 Gene

Genes around NUP188 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUP188 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUP188 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP188 Gene

Proteins for NUP188 Gene

  • Protein details for NUP188 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleoporin NUP188 homolog
    Protein Accession:
    Secondary Accessions:
    • Q14675
    • Q2TA87
    • Q7Z3K8
    • Q8IWF1

    Protein attributes for NUP188 Gene

    1749 amino acids
    Molecular mass:
    196043 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAD97835.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for NUP188 Gene


neXtProt entry for NUP188 Gene

Proteomics data for NUP188 Gene at MOPED

Post-translational modifications for NUP188 Gene

  • Ubiquitination at Lys 38, Lys 344, Lys 470, Lys 479, Lys 481, Lys 500, Lys 720, Lys 812, Lys 1409, Lys 1496, Lys 1684, and Lys 1727
  • Modification sites at PhosphoSitePlus

Other Protein References for NUP188 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NUP188 Gene

Domains & Families for NUP188 Gene

Gene Families for NUP188 Gene

Protein Domains for NUP188 Gene

Suggested Antigen Peptide Sequences for NUP188 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NUP188: view

No data available for UniProtKB/Swiss-Prot for NUP188 Gene

Function for NUP188 Gene

Molecular function for NUP188 Gene

UniProtKB/Swiss-Prot Function:
May function as a component of the nuclear pore complex (NPC).
genes like me logo Genes that share phenotypes with NUP188: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUP188 Gene

Localization for NUP188 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP188 Gene

Nucleus, nuclear pore complex.

Subcellular locations from

Jensen Localization Image for NUP188 Gene COMPARTMENTS Subcellular localization image for NUP188 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for NUP188 Gene

Pathways & Interactions for NUP188 Gene

SuperPathways for NUP188 Gene

Superpath Contained pathways
1 Regulation of Glucokinase by Glucokinase Regulatory Protein
2 Infectious disease
3 Cell Cycle, Mitotic
4 Mitotic Prophase
5 Influenza Viral RNA Transcription and Replication
genes like me logo Genes that share pathways with NUP188: view

Pathways by source for NUP188 Gene

Gene Ontology (GO) - Biological Process for NUP188 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006405 RNA export from nucleus IBA --
GO:0006606 protein import into nucleus IBA --
GO:0007077 mitotic nuclear envelope disassembly TAS --
GO:0008033 tRNA processing TAS --
genes like me logo Genes that share ontologies with NUP188: view

No data available for SIGNOR curated interactions for NUP188 Gene

Drugs & Compounds for NUP188 Gene

No Compound Related Data Available

Transcripts for NUP188 Gene

Unigene Clusters for NUP188 Gene

Nucleoporin 188kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUP188 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^

ExUns: 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29a · 29b ^ 30a · 30b ^ 31 ^ 32a · 32b ^ 33a · 33b ^ 34 ^ 35 ^ 36 ^ 37 ^ 38a · 38b ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44
SP1: - - - -
SP2: - - -
SP5: - -

Relevant External Links for NUP188 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NUP188 Gene

mRNA expression in normal human tissues for NUP188 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NUP188 Gene

This gene is overexpressed in Synovial fluid (15.2) and Cerebrospinal fluid (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUP188 Gene

SOURCE GeneReport for Unigene cluster for NUP188 Gene Hs.308340

genes like me logo Genes that share expression patterns with NUP188: view

Protein tissue co-expression partners for NUP188 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NUP188 Gene

Orthologs for NUP188 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUP188 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NUP188 35
  • 90.24 (n)
  • 95.88 (a)
-- 36
  • 96 (a)
(Canis familiaris)
Mammalia NUP188 35
  • 90.78 (n)
  • 95.82 (a)
-- 36
  • 96 (a)
(Mus musculus)
Mammalia Nup188 35
  • 87.57 (n)
  • 94.28 (a)
Nup188 16
Nup188 36
  • 94 (a)
(Pan troglodytes)
Mammalia NUP188 35
  • 99.49 (n)
  • 99.71 (a)
NUP188 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Nup188 35
  • 87.38 (n)
  • 94.51 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 92 (a)
(Gallus gallus)
Aves NUP188 35
  • 76.59 (n)
  • 85.93 (a)
NUP188 36
  • 86 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nup188 35
  • 69.72 (n)
  • 72.13 (a)
Str.4929 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.20942 35
(Danio rerio)
Actinopterygii nup188 35
  • 68.2 (n)
  • 72.72 (a)
wufk95d02 35
nup188 36
  • 72 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8771 36
  • 19 (a)
Species with no ortholog for NUP188:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUP188 Gene

Gene Tree for NUP188 (if available)
Gene Tree for NUP188 (if available)

Paralogs for NUP188 Gene

Paralogs for NUP188 Gene

genes like me logo Genes that share paralogs with NUP188: view

Variants for NUP188 Gene

Sequence variations from dbSNP and Humsavar for NUP188 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_034792 -
VAR_034793 -
rs719703 -- 128,983,269(-) ACTAT(A/G)CTCAA intron-variant
rs7855915 -- 128,953,986(+) cacca(C/T)gccca intron-variant
rs7858951 -- 128,984,280(+) cacca(C/G)cacgc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUP188 Gene

Variant ID Type Subtype PubMed ID
nsv893902 CNV Gain 21882294
dgv8297n71 CNV Loss 21882294
nsv831729 CNV Loss 17160897
nsv509323 CNV Insertion 20534489
esv2739079 CNV Deletion 23290073

Variation tolerance for NUP188 Gene

Residual Variation Intolerance Score: 4.87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.41; 63.77% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NUP188 Gene

Disorders for NUP188 Gene


  • Note=Copy number variations of NUP188 gene may be a cause of heterotaxy, a congenital heart disease resulting from abnormalities in left-right (LR) body patterning. {ECO:0000269 PubMed:21282601}.

Relevant External Links for NUP188

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NUP188 Gene.

No data available for MalaCards and Genatlas for NUP188 Gene

Publications for NUP188 Gene

  1. Identification of a new vertebrate nucleoporin, Nup188, with the use of a novel organelle trap assay. (PMID: 11029043) Miller B.R. … Forbes D.J. (Mol. Biol. Cell 2000) 2 3 4 67
  2. KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and lysosome-mediated degradation. (PMID: 25582440) Hong J.H. … Raught B. (Mol. Cell Proteomics 2015) 3
  3. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for NUP188 Gene

Sources for NUP188 Gene