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Aliases for NUP188 Gene

Aliases for NUP188 Gene

  • Nucleoporin 188kDa 2 3
  • KIAA0169 2 3 4
  • HNup188 3 4
  • Nucleoporin NUP188 Homolog 3
  • KIAA1069 6

External Ids for NUP188 Gene

Previous HGNC Symbols for NUP188 Gene

  • KIAA0169

Previous GeneCards Identifiers for NUP188 Gene

  • GC09U900613
  • GC09P128789
  • GC09P130749
  • GC09P131709
  • GC09P101317

Summaries for NUP188 Gene

Entrez Gene Summary for NUP188 Gene

  • The nuclear pore complex (NPC) is found on the nuclear envelope and forms a gateway that regulates the flow of proteins and RNAs between the cytoplasm and nucleoplasm. The NPC is comprised of approximately 30 distinct proteins collectively known as nucleoporins. Nucleoporins are pore-complex-specific glycoproteins which often have cytoplasmically oriented O-linked N-acetylglucosamine residues and numerous repeats of the pentapeptide sequence XFXFG. However, the nucleoporin protein encoded by this gene does not contain the typical FG repeat sequences found in most vertebrate nucleoporins. This nucleoporin is thought to form part of the scaffold for the central channel of the nuclear pore. [provided by RefSeq, Jan 2013]

GeneCards Summary for NUP188 Gene

NUP188 (Nucleoporin 188kDa) is a Protein Coding gene. Among its related pathways are Disease and Cell Cycle, Mitotic. An important paralog of this gene is ENSG00000251184.

UniProtKB/Swiss-Prot for NUP188 Gene

  • May function as a component of the nuclear pore complex (NPC)

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP188 Gene

Genomics for NUP188 Gene

Regulatory Elements for NUP188 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NUP188 Gene

Start:
128,947,693 bp from pter
End:
129,007,096 bp from pter
Size:
59,404 bases
Orientation:
Plus strand

Genomic View for NUP188 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUP188 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP188 Gene

Proteins for NUP188 Gene

  • Protein details for NUP188 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SRE5-NU188_HUMAN
    Recommended name:
    Nucleoporin NUP188 homolog
    Protein Accession:
    Q5SRE5
    Secondary Accessions:
    • Q14675
    • Q2TA87
    • Q7Z3K8
    • Q8IWF1

    Protein attributes for NUP188 Gene

    Size:
    1749 amino acids
    Molecular mass:
    196043 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAD97835.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for NUP188 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUP188 Gene

Proteomics data for NUP188 Gene at MOPED

Post-translational modifications for NUP188 Gene

  • Ubiquitination at Lys38, Lys344, Lys470, Lys479, Lys481, Lys500, Lys720, Lys812, Lys876, Lys1409, Lys1496, Lys1684, and Lys1727
  • Modification sites at PhosphoSitePlus

Other Protein References for NUP188 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NUP188 Gene

Domains for NUP188 Gene

Protein Domains for NUP188 Gene

Suggested Antigen Peptide Sequences for NUP188 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NUP188: view

No data available for Gene Families and UniProtKB/Swiss-Prot for NUP188 Gene

Function for NUP188 Gene

Molecular function for NUP188 Gene

UniProtKB/Swiss-Prot Function: May function as a component of the nuclear pore complex (NPC)

Gene Ontology (GO) - Molecular Function for NUP188 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
genes like me logo Genes that share ontologies with NUP188: view

Animal Model Products

CRISPR Products

miRNA for NUP188 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NUP188 Gene

Localization for NUP188 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP188 Gene

Nucleus, nuclear pore complex.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUP188 Gene COMPARTMENTS Subcellular localization image for NUP188 gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NUP188 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope TAS --
GO:0005643 nuclear pore IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with NUP188: view

Pathways for NUP188 Gene

SuperPathways for NUP188 Gene

genes like me logo Genes that share pathways with NUP188: view

Pathways by source for NUP188 Gene

42 Reactome pathways for NUP188 Gene
1 KEGG pathway for NUP188 Gene

Gene Ontology (GO) - Biological Process for NUP188 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0005975 carbohydrate metabolic process TAS --
GO:0007077 mitotic nuclear envelope disassembly TAS --
GO:0008645 hexose transport TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with NUP188: view

Transcripts for NUP188 Gene

Unigene Clusters for NUP188 Gene

Nucleoporin 188kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NUP188

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NUP188

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUP188 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

ExUns: 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29a · 29b ^ 30a · 30b ^ 31 ^ 32a · 32b ^ 33a · 33b ^ 34 ^ 35 ^ 36 ^ 37 ^ 38a · 38b ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44
SP1: - - - -
SP2: - - -
SP3:
SP4:
SP5: - -
SP6:
SP7:

Relevant External Links for NUP188 Gene

GeneLoc Exon Structure for
NUP188
ECgene alternative splicing isoforms for
NUP188

Expression for NUP188 Gene

mRNA expression in normal human tissues for NUP188 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUP188 Gene

SOURCE GeneReport for Unigene cluster for NUP188 Gene Hs.308340

genes like me logo Genes that share expressions with NUP188: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NUP188 Gene

Orthologs for NUP188 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUP188 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUP188 35
  • 99.49 (n)
  • 99.71 (a)
NUP188 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 96 (a)
OneToMany
NUP188 35
  • 90.24 (n)
  • 95.88 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 96 (a)
OneToMany
NUP188 35
  • 90.78 (n)
  • 95.82 (a)
mouse
(Mus musculus)
Mammalia Nup188 35
  • 87.57 (n)
  • 94.28 (a)
Nup188 16
Nup188 36
  • 94 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 92 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 92 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nup188 35
  • 87.38 (n)
  • 94.51 (a)
chicken
(Gallus gallus)
Aves NUP188 35
  • 76.59 (n)
  • 85.93 (a)
NUP188 36
  • 86 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 74 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.20942 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nup188 35
  • 69.72 (n)
  • 72.13 (a)
Str.4929 35
zebrafish
(Danio rerio)
Actinopterygii nup188 35
  • 68.2 (n)
  • 72.72 (a)
nup188 36
  • 72 (a)
OneToMany
wufk95d02 35
fruit fly
(Drosophila melanogaster)
Insecta CG8771 36
  • 19 (a)
OneToMany
Species with no ortholog for NUP188:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUP188 Gene

ENSEMBL:
Gene Tree for NUP188 (if available)
TreeFam:
Gene Tree for NUP188 (if available)

Paralogs for NUP188 Gene

Paralogs for NUP188 Gene

genes like me logo Genes that share paralogs with NUP188: view

Variants for NUP188 Gene

Sequence variations from dbSNP and Humsavar for NUP188 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs719703 -- 128,983,269(-) ACTAT(A/G)CTCAA intron-variant
rs2146293 -- 128,992,886(-) AGCAA(C/G)GATAG intron-variant
rs2146294 -- 128,951,517(-) ataat(A/T)taaat intron-variant
rs2181257 -- 128,968,919(+) TCTTT(C/T)ACTTA intron-variant
rs2181258 -- 128,968,923(+) TTACT(C/T)ACTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUP188 Gene

Variant ID Type Subtype PubMed ID
nsv893902 CNV Gain 21882294
dgv8297n71 CNV Loss 21882294
nsv831729 CNV Loss 17160897
nsv509323 CNV Insertion 20534489
esv2739079 CNV Deletion 23290073

Relevant External Links for NUP188 Gene

HapMap Linkage Disequilibrium report
NUP188

PCR Panel Products

  • Copy Number PCR Panels: for NUP188

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUP188 Gene

Disorders for NUP188 Gene

UniProtKB/Swiss-Prot

NU188_HUMAN
  • Note=Copy number variations of NUP188 gene may be a cause of heterotaxy, a congenital heart disease resulting from abnormalities in left-right (LR) body patterning. {ECO:0000269 PubMed:21282601}.

No disorders were found for NUP188 Gene.

Publications for NUP188 Gene

  1. Identification of a new vertebrate nucleoporin, Nup188, with the use of a novel organelle trap assay. (PMID: 11029043) Miller B.R. … Forbes D.J. (Mol. Biol. Cell 2000) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8724849) Nagase T. … Nomura N. (DNA Res. 1996) 3 4
  3. The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates. (PMID: 10668806) Bachi A. … Izaurralde E. (RNA 2000) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3

Products for NUP188 Gene

Sources for NUP188 Gene

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