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Aliases for NUP160 Gene

Aliases for NUP160 Gene

  • Nucleoporin 160kDa 2 3 5
  • 160 KDa Nucleoporin 4
  • Nucleoporin Nup160 4
  • Nucleoporin 160kD 2
  • KIAA0197 4
  • NUP120 4

External Ids for NUP160 Gene

Previous GeneCards Identifiers for NUP160 Gene

  • GC11M049712
  • GC11M048677
  • GC11M047831
  • GC11M047763
  • GC11M047757
  • GC11M047505
  • GC11M047866
  • GC11M048084
  • GC11M048807
  • GC11M049912
  • GC11M047973
  • GC11M048098

Summaries for NUP160 Gene

Entrez Gene Summary for NUP160 Gene

  • NUP160 is 1 of up to 60 proteins that make up the 120-MD nuclear pore complex, which mediates nucleoplasmic transport.[supplied by OMIM, Apr 2004]

GeneCards Summary for NUP160 Gene

NUP160 (Nucleoporin 160kDa) is a Protein Coding gene. Diseases associated with NUP160 include Angiosarcoma. Among its related pathways are Mitotic Metaphase and Anaphase and Cellular response to heat stress. GO annotations related to this gene include nucleocytoplasmic transporter activity.

UniProtKB/Swiss-Prot for NUP160 Gene

  • Involved in poly(A)+ RNA transport.

Gene Wiki entry for NUP160 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP160 Gene

Genomics for NUP160 Gene

Regulatory Elements for NUP160 Gene

Enhancers for NUP160 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NUP160 on UCSC Golden Path with GeneCards custom track

Promoters for NUP160 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NUP160 on UCSC Golden Path with GeneCards custom track

Genomic Location for NUP160 Gene

47,778,087 bp from pter
47,848,555 bp from pter
70,469 bases
Minus strand

Genomic View for NUP160 Gene

Genes around NUP160 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUP160 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUP160 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP160 Gene

Proteins for NUP160 Gene

  • Protein details for NUP160 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nuclear pore complex protein Nup160
    Protein Accession:
    Secondary Accessions:
    • B4DYE8
    • B4E2J9
    • Q08AD3
    • Q7Z5X6
    • Q96GB3
    • Q9H660

    Protein attributes for NUP160 Gene

    1436 amino acids
    Molecular mass:
    162121 Da
    Quaternary structure:
    • Forms part of the Nup160 subcomplex in the nuclear pore which is composed of NUP160, NUP133, NUP107 and Nup96. This complex plays a role in RNA export and in tethering Nup98 and NUP153 to the nucleus.
    • Sequence=AAH09822.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA12110.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact. Aberrant splice sites.; Evidence={ECO:0000305}; Sequence=BAB15406.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG65161.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NUP160 Gene

    Alternative splice isoforms for NUP160 Gene


neXtProt entry for NUP160 Gene

Proteomics data for NUP160 Gene at MOPED

Post-translational modifications for NUP160 Gene

  • Ubiquitination at Lys 131, Lys 343, Lys 925, Lys 939, Lys 965, Lys 1006, Lys 1120, Lys 1185, and Lys 1415
  • Modification sites at PhosphoSitePlus

Other Protein References for NUP160 Gene

Antibody Products

  • Cloud-Clone Corp. Antibodies for NUP160

No data available for DME Specific Peptides for NUP160 Gene

Domains & Families for NUP160 Gene

Gene Families for NUP160 Gene

Protein Domains for NUP160 Gene


Suggested Antigen Peptide Sequences for NUP160 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NUP160: view

No data available for UniProtKB/Swiss-Prot for NUP160 Gene

Function for NUP160 Gene

Molecular function for NUP160 Gene

UniProtKB/Swiss-Prot Function:
Involved in poly(A)+ RNA transport.
genes like me logo Genes that share phenotypes with NUP160: view

Animal Model Products

miRNA for NUP160 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUP160 Gene

Localization for NUP160 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP160 Gene

Nucleus, nuclear pore complex.

Subcellular locations from

Jensen Localization Image for NUP160 Gene COMPARTMENTS Subcellular localization image for NUP160 gene
Compartment Confidence
cytosol 5
nucleus 5
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NUP160 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031080 nuclear pore outer ring NAS 15146057
genes like me logo Genes that share ontologies with NUP160: view

Pathways & Interactions for NUP160 Gene

SuperPathways for NUP160 Gene

Superpath Contained pathways
1 Regulation of Glucokinase by Glucokinase Regulatory Protein
2 Infectious disease
3 Cell Cycle, Mitotic
4 Mitotic Prophase
5 Influenza Viral RNA Transcription and Replication
genes like me logo Genes that share pathways with NUP160: view

Pathways by source for NUP160 Gene

Gene Ontology (GO) - Biological Process for NUP160 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006409 tRNA export from nucleus TAS --
GO:0007062 sister chromatid cohesion TAS --
GO:0007077 mitotic nuclear envelope disassembly TAS --
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with NUP160: view

No data available for SIGNOR curated interactions for NUP160 Gene

Drugs & Compounds for NUP160 Gene

No Compound Related Data Available

Transcripts for NUP160 Gene

Unigene Clusters for NUP160 Gene

Nucleoporin 160kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUP160 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^
SP1: - - -
SP2: - - - -
SP6: -

ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29a · 29b · 29c ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35a · 35b ^ 36 ^ 37 ^ 38a · 38b
SP1: - - - -
SP2: - - - -
SP3: -

Relevant External Links for NUP160 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NUP160 Gene

mRNA expression in normal human tissues for NUP160 Gene

Protein differential expression in normal tissues from HIPED for NUP160 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.7) and Lymph node (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUP160 Gene

SOURCE GeneReport for Unigene cluster for NUP160 Gene Hs.744107

genes like me logo Genes that share expression patterns with NUP160: view

Protein tissue co-expression partners for NUP160 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NUP160 Gene

Orthologs for NUP160 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUP160 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NUP160 35
  • 90.35 (n)
  • 93.94 (a)
NUP160 36
  • 92 (a)
(Canis familiaris)
Mammalia NUP160 35
  • 90.52 (n)
  • 92.39 (a)
NUP160 36
  • 93 (a)
(Mus musculus)
Mammalia Nup160 35
  • 88.23 (n)
  • 92.72 (a)
Nup160 16
Nup160 36
  • 93 (a)
(Pan troglodytes)
Mammalia NUP160 35
  • 99.58 (n)
  • 99.37 (a)
NUP160 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Nup160 35
  • 89 (n)
  • 93.55 (a)
(Monodelphis domestica)
Mammalia NUP160 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia NUP160 36
  • 77 (a)
(Gallus gallus)
Aves NUP160 35
  • 69.71 (n)
  • 74.95 (a)
NUP160 36
  • 71 (a)
(Anolis carolinensis)
Reptilia NUP160 36
  • 70 (a)
(Danio rerio)
Actinopterygii nup160 35
  • 63.48 (n)
  • 63.65 (a)
zgc66306 35
CABZ01080568.2 36
  • 64 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4738 37
  • 30 (a)
Nup160 35
  • 43.63 (n)
  • 31.18 (a)
Nup160 36
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
CSA.8115 36
  • 32 (a)
Species with no ortholog for NUP160:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUP160 Gene

Gene Tree for NUP160 (if available)
Gene Tree for NUP160 (if available)

Paralogs for NUP160 Gene

No data available for Paralogs for NUP160 Gene

Variants for NUP160 Gene

Sequence variations from dbSNP and Humsavar for NUP160 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2305984 - 47,848,303(+) CAGGG(A/C/G/T)TCCCG reference, missense
rs3816605 - 47,835,701(+) CATGG(C/G/T)GGGGG reference, missense, utr-variant-5-prime
rs754434 -- 47,792,728(+) AAACA(A/G)GTAGA intron-variant
rs930940 -- 47,799,601(-) GCCAC(C/T)GCACT intron-variant
rs1227976 -- 47,850,423(+) gagga(C/T)acagt upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NUP160 Gene

Variant ID Type Subtype PubMed ID
nsv469858 CNV Gain 16826518
nsv832143 CNV Loss 17160897
nsv825874 CNV Loss 20364138
esv2669124 CNV Deletion 23128226

Variation tolerance for NUP160 Gene

Residual Variation Intolerance Score: 3.99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.44; 71.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUP160 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUP160 Gene

Disorders for NUP160 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NUP160 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • hemangiosarcoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NUP160

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NUP160: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUP160 Gene

Publications for NUP160 Gene

  1. Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export. (PMID: 11684705) Vasu S. … Forbes D.J. (J. Cell Biol. 2001) 2 3 4 23 67
  2. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  3. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for NUP160 Gene

Sources for NUP160 Gene