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Aliases for NUP160 Gene

Aliases for NUP160 Gene

  • Nucleoporin 160 2 3 5
  • 160 KDa Nucleoporin 4
  • Nucleoporin 160kDa 2
  • Nucleoporin Nup160 4
  • KIAA0197 4
  • NUP120 4

External Ids for NUP160 Gene

Previous GeneCards Identifiers for NUP160 Gene

  • GC11M049712
  • GC11M048677
  • GC11M047831
  • GC11M047763
  • GC11M047757
  • GC11M047505
  • GC11M047866
  • GC11M048084
  • GC11M048807
  • GC11M049912
  • GC11M047973
  • GC11M048098
  • GC11M050811

Summaries for NUP160 Gene

Entrez Gene Summary for NUP160 Gene

  • NUP160 is 1 of up to 60 proteins that make up the 120-MD nuclear pore complex, which mediates nucleoplasmic transport.[supplied by OMIM, Apr 2004]

GeneCards Summary for NUP160 Gene

NUP160 (Nucleoporin 160) is a Protein Coding gene. Diseases associated with NUP160 include Angiosarcoma. Among its related pathways are Transport of Mature Transcript to Cytoplasm and Regulation of Glucokinase by Glucokinase Regulatory Protein. GO annotations related to this gene include nucleocytoplasmic transporter activity.

UniProtKB/Swiss-Prot for NUP160 Gene

  • Involved in poly(A)+ RNA transport.

Gene Wiki entry for NUP160 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP160 Gene

Genomics for NUP160 Gene

Regulatory Elements for NUP160 Gene

Enhancers for NUP160 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around NUP160 on UCSC Golden Path with GeneCards custom track

Promoters for NUP160 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for NUP160 Gene

Chromosome:
11
Start:
47,778,087 bp from pter
End:
47,848,555 bp from pter
Size:
70,469 bases
Orientation:
Minus strand

Genomic View for NUP160 Gene

Genes around NUP160 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUP160 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUP160 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP160 Gene

Proteins for NUP160 Gene

  • Protein details for NUP160 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12769-NU160_HUMAN
    Recommended name:
    Nuclear pore complex protein Nup160
    Protein Accession:
    Q12769
    Secondary Accessions:
    • B4DYE8
    • B4E2J9
    • Q08AD3
    • Q7Z5X6
    • Q96GB3
    • Q9H660

    Protein attributes for NUP160 Gene

    Size:
    1436 amino acids
    Molecular mass:
    162121 Da
    Quaternary structure:
    • Forms part of the Nup160 subcomplex in the nuclear pore which is composed of NUP160, NUP133, NUP107 and Nup96. This complex plays a role in RNA export and in tethering Nup98 and NUP153 to the nucleus.
    SequenceCaution:
    • Sequence=AAH09822.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA12110.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact. Aberrant splice sites.; Evidence={ECO:0000305}; Sequence=BAB15406.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG65161.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NUP160 Gene

    Alternative splice isoforms for NUP160 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUP160 Gene

Post-translational modifications for NUP160 Gene

  • Ubiquitination at Lys 131, Lys 343, Lys 925, Lys 939, Lys 965, Lys 1006, Lys 1120, Lys 1185, and Lys 1415
  • Modification sites at PhosphoSitePlus

Other Protein References for NUP160 Gene

Antibody Products

No data available for DME Specific Peptides for NUP160 Gene

Domains & Families for NUP160 Gene

Gene Families for NUP160 Gene

Protein Domains for NUP160 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for NUP160 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NUP160: view

No data available for UniProtKB/Swiss-Prot for NUP160 Gene

Function for NUP160 Gene

Molecular function for NUP160 Gene

UniProtKB/Swiss-Prot Function:
Involved in poly(A)+ RNA transport.

Gene Ontology (GO) - Molecular Function for NUP160 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005487 nucleocytoplasmic transporter activity IDA 11684705
GO:0005515 protein binding IPI 15146057
genes like me logo Genes that share ontologies with NUP160: view
genes like me logo Genes that share phenotypes with NUP160: view

Animal Model Products

CRISPR Products

miRNA for NUP160 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUP160 Gene

Localization for NUP160 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP160 Gene

Nucleus, nuclear pore complex.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUP160 Gene COMPARTMENTS Subcellular localization image for NUP160 gene
Compartment Confidence
cytosol 5
nucleus 5
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NUP160 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 colocalizes_with kinetochore IDA 15146057
GO:0005635 nuclear envelope TAS --
GO:0005643 nuclear pore IDA 11564755
GO:0005829 cytosol TAS --
GO:0031080 nuclear pore outer ring NAS 15146057
genes like me logo Genes that share ontologies with NUP160: view

Pathways & Interactions for NUP160 Gene

SuperPathways for NUP160 Gene

Superpath Contained pathways
1 Regulation of Glucokinase by Glucokinase Regulatory Protein
2 Infectious disease
.48
3 Cell Cycle, Mitotic
.61
4 Mitotic Prophase
5 Influenza Viral RNA Transcription and Replication
genes like me logo Genes that share pathways with NUP160: view

Pathways by source for NUP160 Gene

Gene Ontology (GO) - Biological Process for NUP160 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006406 mRNA export from nucleus TAS --
GO:0006409 tRNA export from nucleus TAS --
GO:0007062 sister chromatid cohesion TAS --
GO:0007077 mitotic nuclear envelope disassembly TAS --
GO:0010827 regulation of glucose transport TAS --
genes like me logo Genes that share ontologies with NUP160: view

No data available for SIGNOR curated interactions for NUP160 Gene

Drugs & Compounds for NUP160 Gene

No Compound Related Data Available

Transcripts for NUP160 Gene

Unigene Clusters for NUP160 Gene

Nucleoporin 160kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUP160 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^
SP1: - - -
SP2: - - - -
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:

ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29a · 29b · 29c ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35a · 35b ^ 36 ^ 37 ^ 38a · 38b
SP1: - - - -
SP2: - - - -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for NUP160 Gene

GeneLoc Exon Structure for
NUP160
ECgene alternative splicing isoforms for
NUP160

Expression for NUP160 Gene

mRNA expression in normal human tissues for NUP160 Gene

Protein differential expression in normal tissues from HIPED for NUP160 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.7) and Lymph node (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NUP160 Gene



Protein tissue co-expression partners for NUP160 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NUP160 Gene:

NUP160

SOURCE GeneReport for Unigene cluster for NUP160 Gene:

Hs.744107
genes like me logo Genes that share expression patterns with NUP160: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NUP160 Gene

Orthologs for NUP160 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUP160 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NUP160 34
  • 90.35 (n)
  • 93.94 (a)
NUP160 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUP160 34
  • 90.52 (n)
  • 92.39 (a)
NUP160 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nup160 34
  • 88.23 (n)
  • 92.72 (a)
Nup160 16
Nup160 35
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NUP160 34
  • 99.58 (n)
  • 99.37 (a)
NUP160 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nup160 34
  • 89 (n)
  • 93.55 (a)
oppossum
(Monodelphis domestica)
Mammalia NUP160 35
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUP160 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUP160 34
  • 69.71 (n)
  • 74.95 (a)
NUP160 35
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUP160 35
  • 70 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nup160 34
  • 63.48 (n)
  • 63.65 (a)
zgc66306 34
CABZ01080568.2 35
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG4738 36
  • 30 (a)
Nup160 34
  • 43.63 (n)
  • 31.18 (a)
Nup160 35
  • 28 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 24 (a)
OneToMany
CSA.8115 35
  • 32 (a)
OneToMany
Species where no ortholog for NUP160 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUP160 Gene

ENSEMBL:
Gene Tree for NUP160 (if available)
TreeFam:
Gene Tree for NUP160 (if available)

Paralogs for NUP160 Gene

No data available for Paralogs for NUP160 Gene

Variants for NUP160 Gene

Sequence variations from dbSNP and Humsavar for NUP160 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2305984 - 47,848,303(+) CAGGG(A/C/G/T)TCCCG reference, missense
rs3816605 - 47,835,701(+) CATGG(C/G/T)GGGGG reference, missense, utr-variant-5-prime
rs1227976 -- 47,850,423(+) gagga(C/T)acagt upstream-variant-2KB
rs1234512 -- 47,850,496(+) aGGAG(A/G)AAGGg upstream-variant-2KB
rs1459988 -- 47,820,395(-) TGATT(A/G)TACCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUP160 Gene

Variant ID Type Subtype PubMed ID
dgv1111n100 CNV gain 25217958
esv2669124 CNV deletion 23128226
esv3626209 CNV loss 21293372
esv3626210 CNV gain 21293372
esv3626211 CNV gain 21293372
nsv469858 CNV gain 16826518
nsv825874 CNV loss 20364138
nsv832143 CNV loss 17160897
nsv983009 CNV duplication 23825009

Variation tolerance for NUP160 Gene

Residual Variation Intolerance Score: 3.99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.44; 71.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUP160 Gene

Human Gene Mutation Database (HGMD)
NUP160
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUP160

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUP160 Gene

Disorders for NUP160 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NUP160 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
angiosarcoma
  • hemangiosarcoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NUP160

Genetic Association Database (GAD)
NUP160
Human Genome Epidemiology (HuGE) Navigator
NUP160
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUP160
genes like me logo Genes that share disorders with NUP160: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUP160 Gene

Publications for NUP160 Gene

  1. Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export. (PMID: 11684705) Vasu S. … Forbes D.J. (J. Cell Biol. 2001) 2 3 4 22 65
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 65
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  5. An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells. (PMID: 11564755) Belgareh N. … Doye V. (J. Cell Biol. 2001) 3 4 65

Products for NUP160 Gene

Sources for NUP160 Gene

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