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Aliases for NUP160 Gene

Aliases for NUP160 Gene

  • Nucleoporin 160 2 3 5
  • 160 KDa Nucleoporin 4
  • Nucleoporin 160kDa 2
  • Nucleoporin Nup160 4
  • KIAA0197 4
  • NUP120 4

External Ids for NUP160 Gene

Previous GeneCards Identifiers for NUP160 Gene

  • GC11M049712
  • GC11M048677
  • GC11M047831
  • GC11M047763
  • GC11M047757
  • GC11M047505
  • GC11M047866
  • GC11M048084
  • GC11M048807
  • GC11M049912
  • GC11M047973
  • GC11M048098
  • GC11M050811
  • GC11M051606
  • GC11M052268
  • GC11M052928
  • GC11M053596

Summaries for NUP160 Gene

Entrez Gene Summary for NUP160 Gene

  • NUP160 is 1 of up to 60 proteins that make up the 120-MD nuclear pore complex, which mediates nucleoplasmic transport.[supplied by OMIM, Apr 2004]

GeneCards Summary for NUP160 Gene

NUP160 (Nucleoporin 160) is a Protein Coding gene. Among its related pathways are Mitotic Prophase and SUMOylation. Gene Ontology (GO) annotations related to this gene include nuclear pore activity.

UniProtKB/Swiss-Prot for NUP160 Gene

  • Involved in poly(A)+ RNA transport.

Gene Wiki entry for NUP160 Gene

Additional gene information for NUP160 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP160 Gene

Genomics for NUP160 Gene

GeneHancer (GH) Regulatory Elements for NUP160 Gene

Promoters and enhancers for NUP160 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I047846 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 565.3 +0.4 367 2.8 HDGF PKNOX1 SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 NUP160 C1QTNF4 FNBP4 ENSG00000270060 DDB2 YPEL5P2
GH11I047577 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 105.6 +269.7 269689 3.1 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 KBTBD4 ENSG00000231880 NDUFS3 FNBP4 NUP160 ENSG00000200090 ENSG00000270060 DDB2 ZNF408 CELF1
GH11I047506 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 136.2 +335.0 334974 14.4 HDGF PKNOX1 ZFP64 ZNF213 FOS JUNB ZC3H11A REST SREBF1 SMARCA4 ENSG00000270072 NUP160 FNBP4 ENSG00000200090 ENSG00000270060 C1QTNF4 ZNF408 DDB2 AMBRA1 CELF1
GH11I047175 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 61.6 +670.8 670815 4.7 HDGF HNRNPUL1 PKNOX1 CLOCK FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ARFGAP2 MIR6745 NUP160 FNBP4 ENSG00000270060 ENSG00000200090 DDB2 RPS10P19 ZNF408 LRP4
GH11I047373 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 50 +471.9 471913 6.2 HDGF PKNOX1 SMAD1 ARID4B SIN3A YBX1 POLR2B ZNF766 CBX5 ZNF207 SPI1 GC11M054465 FNBP4 NUP160 ENSG00000200090 ENSG00000270060 C1QTNF4 SLC39A13 PSMC3 DDB2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NUP160 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NUP160 gene promoter:

Genomic Locations for NUP160 Gene

Genomic Locations for NUP160 Gene
70,469 bases
Minus strand

Genomic View for NUP160 Gene

Genes around NUP160 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUP160 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUP160 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP160 Gene

Proteins for NUP160 Gene

  • Protein details for NUP160 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nuclear pore complex protein Nup160
    Protein Accession:
    Secondary Accessions:
    • B4DYE8
    • B4E2J9
    • Q08AD3
    • Q7Z5X6
    • Q96GB3
    • Q9H660

    Protein attributes for NUP160 Gene

    1436 amino acids
    Molecular mass:
    162121 Da
    Quaternary structure:
    • Forms part of the Nup160 subcomplex in the nuclear pore which is composed of NUP160, NUP133, NUP107 and Nup96. This complex plays a role in RNA export and in tethering Nup98 and NUP153 to the nucleus.
    • Sequence=AAH09822.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA12110.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact. Aberrant splice sites.; Evidence={ECO:0000305}; Sequence=BAB15406.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG65161.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NUP160 Gene

    Alternative splice isoforms for NUP160 Gene


neXtProt entry for NUP160 Gene

Post-translational modifications for NUP160 Gene

  • Ubiquitination at isoforms=2131, Lys343, Lys925, isoforms=939, Lys965, isoforms=1006, Lys1120, Lys1185, and isoforms=1415

Other Protein References for NUP160 Gene

No data available for DME Specific Peptides for NUP160 Gene

Domains & Families for NUP160 Gene

Gene Families for NUP160 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for NUP160 Gene


Suggested Antigen Peptide Sequences for NUP160 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NUP160: view

No data available for UniProtKB/Swiss-Prot for NUP160 Gene

Function for NUP160 Gene

Molecular function for NUP160 Gene

UniProtKB/Swiss-Prot Function:
Involved in poly(A)+ RNA transport.

Phenotypes From GWAS Catalog for NUP160 Gene

Gene Ontology (GO) - Molecular Function for NUP160 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005487 nuclear pore activity IDA 11684705
GO:0005515 protein binding IPI 15146057
genes like me logo Genes that share ontologies with NUP160: view
genes like me logo Genes that share phenotypes with NUP160: view

Animal Model Products

CRISPR Products

miRNA for NUP160 Gene

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUP160 Gene

Localization for NUP160 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP160 Gene

Nucleus, nuclear pore complex.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUP160 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NUP160 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 colocalizes_with kinetochore IDA 15146057
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope TAS --
GO:0005643 nuclear pore IDA,IEA 11564755
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NUP160: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NUP160 Gene

Pathways & Interactions for NUP160 Gene

SuperPathways for NUP160 Gene

SuperPathway Contained pathways
1 Transport of the SLBP independent Mature mRNA
2 HIV Life Cycle
3 Cell Cycle, Mitotic
4 Mitotic Prophase
5 Influenza Viral RNA Transcription and Replication
genes like me logo Genes that share pathways with NUP160: view

Pathways by source for NUP160 Gene

Gene Ontology (GO) - Biological Process for NUP160 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006110 regulation of glycolytic process TAS --
GO:0006406 mRNA export from nucleus TAS --
GO:0006409 tRNA export from nucleus TAS --
GO:0006810 transport IEA --
GO:0007062 sister chromatid cohesion TAS --
genes like me logo Genes that share ontologies with NUP160: view

No data available for SIGNOR curated interactions for NUP160 Gene

Drugs & Compounds for NUP160 Gene

No Compound Related Data Available

Transcripts for NUP160 Gene

Unigene Clusters for NUP160 Gene

Nucleoporin 160kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUP160 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^
SP1: - - -
SP2: - - - -
SP6: -

ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29a · 29b · 29c ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35a · 35b ^ 36 ^ 37 ^ 38a · 38b
SP1: - - - -
SP2: - - - -
SP3: -

Relevant External Links for NUP160 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NUP160 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUP160 Gene

Protein differential expression in normal tissues from HIPED for NUP160 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.7) and Lymph node (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NUP160 Gene

Protein tissue co-expression partners for NUP160 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NUP160 Gene:


SOURCE GeneReport for Unigene cluster for NUP160 Gene:


Evidence on tissue expression from TISSUES for NUP160 Gene

  • Bone marrow(4.2)
  • Intestine(4.2)
  • Liver(4.2)
  • Muscle(4.2)
  • Skin(4.2)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with NUP160: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUP160 Gene

Orthologs for NUP160 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUP160 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NUP160 33 34
  • 99.58 (n)
(Canis familiaris)
Mammalia NUP160 33 34
  • 90.52 (n)
(Bos Taurus)
Mammalia NUP160 33 34
  • 90.35 (n)
(Rattus norvegicus)
Mammalia Nup160 33
  • 89 (n)
(Mus musculus)
Mammalia Nup160 33 16 34
  • 88.23 (n)
(Monodelphis domestica)
Mammalia NUP160 34
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia NUP160 34
  • 77 (a)
(Gallus gallus)
Aves NUP160 33 34
  • 69.71 (n)
(Anolis carolinensis)
Reptilia NUP160 34
  • 70 (a)
(Danio rerio)
Actinopterygii CABZ01080568.2 34
  • 64 (a)
nup160 33
  • 63.48 (n)
zgc66306 33
fruit fly
(Drosophila melanogaster)
Insecta Nup160 33 34
  • 43.63 (n)
CG4738 35
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8115 34
  • 32 (a)
-- 34
  • 24 (a)
Species where no ortholog for NUP160 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUP160 Gene

Gene Tree for NUP160 (if available)
Gene Tree for NUP160 (if available)

Paralogs for NUP160 Gene

No data available for Paralogs for NUP160 Gene

Variants for NUP160 Gene

Sequence variations from dbSNP and Humsavar for NUP160 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000014227 -- 47,802,207(-) T/G genic_downstream_transcript_variant, intron_variant
rs1000039310 -- 47,785,761(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000081862 -- 47,831,134(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000092430 -- 47,817,063(-) C/A genic_downstream_transcript_variant, intron_variant
rs1000161052 -- 47,834,770(-) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NUP160 Gene

Variant ID Type Subtype PubMed ID
dgv1111n100 CNV gain 25217958
esv2669124 CNV deletion 23128226
esv3626209 CNV loss 21293372
esv3626210 CNV gain 21293372
esv3626211 CNV gain 21293372
nsv469858 CNV gain 16826518
nsv825874 CNV loss 20364138
nsv832143 CNV loss 17160897
nsv983009 CNV duplication 23825009

Variation tolerance for NUP160 Gene

Residual Variation Intolerance Score: 3.99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.44; 71.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUP160 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUP160 Gene

Disorders for NUP160 Gene

Additional Disease Information for NUP160

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NUP160 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUP160 Gene

Publications for NUP160 Gene

  1. Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export. (PMID: 11684705) Vasu S … Forbes DJ (The Journal of cell biology 2001) 2 3 4 22 58
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells. (PMID: 11564755) Belgareh N … Doye V (The Journal of cell biology 2001) 3 4 58

Products for NUP160 Gene

Sources for NUP160 Gene

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