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Aliases for NUP155 Gene

Aliases for NUP155 Gene

  • Nucleoporin 155kDa 2 3 5
  • 155 KDa Nucleoporin 3 4
  • Nucleoporin 155kD 2 3
  • Nucleoporin Nup155 4
  • KIAA0791 4
  • ATFB15 3
  • N155 3

External Ids for NUP155 Gene

Previous GeneCards Identifiers for NUP155 Gene

  • GC05M037473
  • GC05M038358
  • GC05M037290
  • GC05M037337
  • GC05M037327

Summaries for NUP155 Gene

Entrez Gene Summary for NUP155 Gene

  • Nucleoporins are proteins that play an important role in the assembly and functioning of the nuclear pore complex (NPC) which regulates the movement of macromolecules across the nuclear envelope (NE). The protein encoded by this gene plays a role in the fusion of NE vesicles and formation of the double membrane NE. The protein may also be involved in cardiac physiology and may be associated with the pathogenesis of atrial fibrillation. Alternative splicing results in multiple transcript variants of this gene. A pseudogene associated with this gene is located on chromosome 6. [provided by RefSeq, May 2013]

GeneCards Summary for NUP155 Gene

NUP155 (Nucleoporin 155kDa) is a Protein Coding gene. Diseases associated with NUP155 include Atrial Fibrillation 15 and Atrial Fibrillation. Among its related pathways are Cellular response to heat stress and Glycosaminoglycan metabolism. GO annotations related to this gene include transporter activity and structural constituent of nuclear pore.

UniProtKB/Swiss-Prot for NUP155 Gene

  • Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport.

Gene Wiki entry for NUP155 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP155 Gene

Genomics for NUP155 Gene

Regulatory Elements for NUP155 Gene

Enhancers for NUP155 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NUP155 on UCSC Golden Path with GeneCards custom track

Promoters for NUP155 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NUP155 on UCSC Golden Path with GeneCards custom track

Genomic Location for NUP155 Gene

37,288,137 bp from pter
37,371,455 bp from pter
83,319 bases
Minus strand

Genomic View for NUP155 Gene

Genes around NUP155 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUP155 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUP155 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP155 Gene

Proteins for NUP155 Gene

  • Protein details for NUP155 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nuclear pore complex protein Nup155
    Protein Accession:
    Secondary Accessions:
    • Q9UBE9
    • Q9UFL5

    Protein attributes for NUP155 Gene

    1391 amino acids
    Molecular mass:
    155199 Da
    Quaternary structure:
    • Interacts with GLE1. Able to form a heterotrimer with GLE1 and NUPL2 in vitro. Forms a complex with NUP53, NUP93, NUP205 and lamin B.
    • Sequence=AAD52966.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA34511.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NUP155 Gene

    Alternative splice isoforms for NUP155 Gene


neXtProt entry for NUP155 Gene

Proteomics data for NUP155 Gene at MOPED

Post-translational modifications for NUP155 Gene

  • Disulfide-linked to NUP62. The the inner channel of the NPC has a different redox environment from the cytoplasm and allows the formation of interchain disulfide bonds between some nucleoporins, the significant increase of these linkages upon oxidative stress reduces the permeability of the NPC (By similarity).
  • Phosphorylated. Phosphorylation and dephosphorylation may be important for the function of NUP155 and may play a role in the reversible disassembly of the nuclear pore complex during mitosis (By similarity).
  • Ubiquitination at Lys 297, Lys 340, Lys 740, Lys 824, Lys 906, Lys 973, Lys 1147, and Lys 1308
  • Glycosylation at Ser 526
  • Modification sites at PhosphoSitePlus

Other Protein References for NUP155 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for NUP155

No data available for DME Specific Peptides for NUP155 Gene

Domains & Families for NUP155 Gene

Gene Families for NUP155 Gene

Suggested Antigen Peptide Sequences for NUP155 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the non-repetitive/WGA-negative nucleoporin family.
  • Belongs to the non-repetitive/WGA-negative nucleoporin family.
genes like me logo Genes that share domains with NUP155: view

Function for NUP155 Gene

Molecular function for NUP155 Gene

GENATLAS Biochemistry:
nucleoporin 155 with two alternative spliced isoforms,ubiquitously expressed,component of nuclear pore complexes,involved in nucleocytoplasmic transport maybe involved in mental and developmental retardation in patients with 5p13 deletion
UniProtKB/Swiss-Prot Function:
Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport.
genes like me logo Genes that share phenotypes with NUP155: view

Human Phenotype Ontology for NUP155 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

miRNA for NUP155 Gene

miRTarBase miRNAs that target NUP155

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for NUP155 Gene

Localization for NUP155 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP155 Gene

Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note=In mitosis, assumes a diffuse cytoplasmic distribution probably as a monomer, before reversing back into a punctate nuclear surface localization at the end of mitosis. {ECO:0000250 UniProtKB:P37199}.

Subcellular locations from

Jensen Localization Image for NUP155 Gene COMPARTMENTS Subcellular localization image for NUP155 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 2
endoplasmic reticulum 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NUP155 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044611 nuclear pore inner ring IBA --
genes like me logo Genes that share ontologies with NUP155: view

Pathways & Interactions for NUP155 Gene

SuperPathways for NUP155 Gene

Superpath Contained pathways
1 Regulation of Glucokinase by Glucokinase Regulatory Protein
2 Infectious disease
3 Cell Cycle, Mitotic
4 Mitotic Prophase
5 Influenza Viral RNA Transcription and Replication
genes like me logo Genes that share pathways with NUP155: view

Pathways by source for NUP155 Gene

Gene Ontology (GO) - Biological Process for NUP155 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery IBA --
GO:0005975 carbohydrate metabolic process TAS --
GO:0006405 RNA export from nucleus IBA --
GO:0006409 tRNA export from nucleus TAS --
GO:0006606 protein import into nucleus IEA,IBA --
genes like me logo Genes that share ontologies with NUP155: view

No data available for SIGNOR curated interactions for NUP155 Gene

Drugs & Compounds for NUP155 Gene

No Compound Related Data Available

Transcripts for NUP155 Gene

Unigene Clusters for NUP155 Gene

Nucleoporin 155kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUP155 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^
SP1: -

ExUns: 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b ^ 32 ^ 33 ^ 34 ^ 35a · 35b ^ 36a · 36b
SP1: - -
SP2: - -

Relevant External Links for NUP155 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NUP155 Gene

mRNA expression in normal human tissues for NUP155 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NUP155 Gene

This gene is overexpressed in Testis (x6.1).

Protein differential expression in normal tissues from HIPED for NUP155 Gene

This gene is overexpressed in Lymph node (11.9) and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUP155 Gene

SOURCE GeneReport for Unigene cluster for NUP155 Gene Hs.547696

mRNA Expression by UniProt/SwissProt for NUP155 Gene

Tissue specificity: Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expression patterns with NUP155: view

Protein tissue co-expression partners for NUP155 Gene

- Elite partner

Primer Products

Orthologs for NUP155 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUP155 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NUP155 35
  • 92.14 (n)
  • 96.26 (a)
NUP155 36
  • 96 (a)
(Canis familiaris)
Mammalia NUP155 35
  • 93.12 (n)
  • 96.69 (a)
NUP155 36
  • 97 (a)
(Mus musculus)
Mammalia Nup155 35
  • 87.58 (n)
  • 94.96 (a)
Nup155 16
Nup155 36
  • 95 (a)
(Pan troglodytes)
Mammalia NUP155 35
  • 99.26 (n)
  • 98.97 (a)
NUP155 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Nup155 35
  • 87.46 (n)
  • 93.81 (a)
(Monodelphis domestica)
Mammalia NUP155 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia NUP155 36
  • 91 (a)
(Gallus gallus)
Aves NUP155 35
  • 78.55 (n)
  • 86.09 (a)
NUP155 36
  • 85 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 78 (a)
-- 36
  • 82 (a)
-- 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nup155 35
  • 72.66 (n)
  • 79.99 (a)
Str.16474 35
African clawed frog
(Xenopus laevis)
Amphibia nup155-prov 35
(Danio rerio)
Actinopterygii nup155 35
  • 65.87 (n)
  • 73.59 (a)
zgc55435 35
nup155 36
  • 73 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nup154 37
  • 31 (a)
Nup154 35
  • 45.59 (n)
  • 35.48 (a)
Nup154 36
  • 33 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007999 35
  • 23.54 (n)
  • 6.07 (a)
(Caenorhabditis elegans)
Secernentea npp-8 35
  • 41.63 (n)
  • 29.73 (a)
npp-8 36
  • 27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NUP157 36
  • 18 (a)
NUP170 36
  • 18 (a)
NUP170 38
thale cress
(Arabidopsis thaliana)
eudicotyledons NUP155 35
  • 44 (n)
  • 30.98 (a)
(Oryza sativa)
Liliopsida Os06g0305200 35
  • 44.31 (n)
  • 31.36 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.412 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
Species with no ortholog for NUP155:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUP155 Gene

Gene Tree for NUP155 (if available)
Gene Tree for NUP155 (if available)

Paralogs for NUP155 Gene Pseudogenes for NUP155 Gene

genes like me logo Genes that share paralogs with NUP155: view

No data available for Paralogs for NUP155 Gene

Variants for NUP155 Gene

Sequence variations from dbSNP and Humsavar for NUP155 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_071762 Atrial fibrillation, familial, 15 (ATFB15)
rs2737076 -- 37,353,872(-) tgtaa(A/C)cttca intron-variant
rs2737077 -- 37,353,380(-) gtctc(A/G)aactc intron-variant
rs53429 -- 37,310,663(+) AGAGA(A/G)GCAAT intron-variant, reference, synonymous-codon
rs56401 -- 37,326,696(+) TGTGA(C/G)AGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUP155 Gene

Variant ID Type Subtype PubMed ID
nsv525478 CNV Loss 19592680
nsv881511 CNV Gain 21882294
nsv830265 CNV Loss 17160897
nsv880406 CNV Gain 21882294
dgv6037n71 CNV Gain 21882294
nsv881512 CNV Gain 21882294
nsv328371 CNV Loss 16902084
esv2496620 CNV Deletion 19546169
dgv29e194 CNV Deletion 18987734
esv2730083 CNV Deletion 23290073
esv2671337 CNV Deletion 23128226
nsv329973 CNV Loss 16902084
nsv881076 CNV Gain 21882294
esv2270645 CNV Deletion 18987734
nsv471012 CNV Gain 18288195

Variation tolerance for NUP155 Gene

Residual Variation Intolerance Score: 1.07% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.26; 40.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUP155 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUP155 Gene

Disorders for NUP155 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NUP155 Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
atrial fibrillation 15
  • atrial fibrillation, familial, 15
atrial fibrillation
  • a-fib
familial atrial fibrillation
  • atrial fibrillation, familial, 1
- elite association - COSMIC cancer census association via MalaCards


  • Atrial fibrillation, familial, 15 (ATFB15) [MIM:615770]: A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. {ECO:0000269 PubMed:19070573}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for NUP155

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NUP155: view

No data available for Genatlas for NUP155 Gene

Publications for NUP155 Gene

  1. Localization of a human nucleoporin 155 gene (NUP155) to the 5p13 region and cloning of its cDNA. (PMID: 10191094) Zhang X. … Bolund L. (Genomics 1999) 2 3 4 67
  2. Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex. (PMID: 15703211) Hawryluk-Gara L.A. … Wozniak R.W. (Mol. Biol. Cell 2005) 3 23
  3. The mRNA export factor human Gle1 interacts with the nuclear pore complex protein Nup155. (PMID: 14645504) Rayala H.J. … Wente S.R. (Mol. Cell. Proteomics 2004) 3 23
  4. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for NUP155 Gene

Sources for NUP155 Gene