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Aliases for NUP155 Gene

Aliases for NUP155 Gene

  • Nucleoporin 155 2 3 5
  • 155 KDa Nucleoporin 3 4
  • Nucleoporin 155kDa 2 3
  • Nuclear Pore Complex Protein Nup155 3
  • Nucleoporin Nup155 4
  • Nucleoporin 155kD 3
  • KIAA0791 4
  • ATFB15 3
  • N155 3

External Ids for NUP155 Gene

Previous GeneCards Identifiers for NUP155 Gene

  • GC05M037473
  • GC05M038358
  • GC05M037290
  • GC05M037337
  • GC05M037327

Summaries for NUP155 Gene

Entrez Gene Summary for NUP155 Gene

  • Nucleoporins are proteins that play an important role in the assembly and functioning of the nuclear pore complex (NPC) which regulates the movement of macromolecules across the nuclear envelope (NE). The protein encoded by this gene plays a role in the fusion of NE vesicles and formation of the double membrane NE. The protein may also be involved in cardiac physiology and may be associated with the pathogenesis of atrial fibrillation. Alternative splicing results in multiple transcript variants of this gene. A pseudogene associated with this gene is located on chromosome 6. [provided by RefSeq, May 2013]

GeneCards Summary for NUP155 Gene

NUP155 (Nucleoporin 155) is a Protein Coding gene. Diseases associated with NUP155 include Atrial Fibrillation 15 and Familial Atrial Fibrillation. Among its related pathways are Interferon gamma signaling and Transport of the SLBP independent Mature mRNA. GO annotations related to this gene include transporter activity and structural constituent of nuclear pore.

UniProtKB/Swiss-Prot for NUP155 Gene

  • Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport.

Gene Wiki entry for NUP155 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP155 Gene

Genomics for NUP155 Gene

Regulatory Elements for NUP155 Gene

Enhancers for NUP155 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F037369 1.2 ENCODE 0.8 +0.6 591 3.0 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 WDR70 C5orf42 OFD1P17 ENSG00000250155 NUP155 GC05P037328
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NUP155 on UCSC Golden Path with GeneCards custom track

Promoters for NUP155 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001278351 555 2601 CREB3L1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 MEF2D

Genomic Location for NUP155 Gene

Chromosome:
5
Start:
37,288,137 bp from pter
End:
37,371,455 bp from pter
Size:
83,319 bases
Orientation:
Minus strand

Genomic View for NUP155 Gene

Genes around NUP155 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUP155 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUP155 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP155 Gene

Proteins for NUP155 Gene

  • Protein details for NUP155 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75694-NU155_HUMAN
    Recommended name:
    Nuclear pore complex protein Nup155
    Protein Accession:
    O75694
    Secondary Accessions:
    • Q9UBE9
    • Q9UFL5

    Protein attributes for NUP155 Gene

    Size:
    1391 amino acids
    Molecular mass:
    155199 Da
    Quaternary structure:
    • Interacts with GLE1. Able to form a heterotrimer with GLE1 and NUPL2 in vitro. Forms a complex with NUP53, NUP93, NUP205 and lamin B.
    SequenceCaution:
    • Sequence=AAD52966.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA34511.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NUP155 Gene

    Alternative splice isoforms for NUP155 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUP155 Gene

Post-translational modifications for NUP155 Gene

  • Disulfide-linked to NUP62. The the inner channel of the NPC has a different redox environment from the cytoplasm and allows the formation of interchain disulfide bonds between some nucleoporins, the significant increase of these linkages upon oxidative stress reduces the permeability of the NPC (By similarity).
  • Phosphorylated. Phosphorylation and dephosphorylation may be important for the function of NUP155 and may play a role in the reversible disassembly of the nuclear pore complex during mitosis (By similarity).
  • Ubiquitination at Lys 297, Lys 340, Lys 740, Lys 824, Lys 906, Lys 973, Lys 1147, and Lys 1308
  • Glycosylation at Ser 526
  • Modification sites at PhosphoSitePlus

Other Protein References for NUP155 Gene

No data available for DME Specific Peptides for NUP155 Gene

Domains & Families for NUP155 Gene

Gene Families for NUP155 Gene

Suggested Antigen Peptide Sequences for NUP155 Gene

Graphical View of Domain Structure for InterPro Entry

O75694

UniProtKB/Swiss-Prot:

NU155_HUMAN :
  • Belongs to the non-repetitive/WGA-negative nucleoporin family.
Family:
  • Belongs to the non-repetitive/WGA-negative nucleoporin family.
genes like me logo Genes that share domains with NUP155: view

Function for NUP155 Gene

Molecular function for NUP155 Gene

GENATLAS Biochemistry:
nucleoporin 155 with two alternative spliced isoforms,ubiquitously expressed,component of nuclear pore complexes,involved in nucleocytoplasmic transport maybe involved in mental and developmental retardation in patients with 5p13 deletion
UniProtKB/Swiss-Prot Function:
Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport.

Gene Ontology (GO) - Molecular Function for NUP155 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity TAS 10191094
GO:0005515 protein binding IPI 25416956
GO:0017056 structural constituent of nuclear pore IEA,IBA --
genes like me logo Genes that share ontologies with NUP155: view
genes like me logo Genes that share phenotypes with NUP155: view

Human Phenotype Ontology for NUP155 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

miRNA for NUP155 Gene

miRTarBase miRNAs that target NUP155

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for NUP155 Gene

Localization for NUP155 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP155 Gene

Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note=In mitosis, assumes a diffuse cytoplasmic distribution probably as a monomer, before reversing back into a punctate nuclear surface localization at the end of mitosis. {ECO:0000250 UniProtKB:P37199}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUP155 gene
Compartment Confidence
nucleus 5
plasma membrane 2
cytosol 2
extracellular 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for NUP155 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope IDA,TAS --
GO:0005643 nuclear pore IEA --
GO:0016020 membrane IEA,IDA 19946888
GO:0031965 nuclear membrane IEA --
genes like me logo Genes that share ontologies with NUP155: view

Pathways & Interactions for NUP155 Gene

SuperPathways for NUP155 Gene

SuperPathway Contained pathways
1 Transport of the SLBP independent Mature mRNA
2 HIV Life Cycle
.45
3 Cell Cycle, Mitotic
.60
4 Mitotic Prophase
5 Influenza Viral RNA Transcription and Replication
genes like me logo Genes that share pathways with NUP155: view

Pathways by source for NUP155 Gene

Gene Ontology (GO) - Biological Process for NUP155 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery IBA --
GO:0006405 RNA export from nucleus IBA --
GO:0006406 mRNA export from nucleus TAS --
GO:0006409 tRNA export from nucleus TAS --
GO:0006606 protein import into nucleus IBA --
genes like me logo Genes that share ontologies with NUP155: view

No data available for SIGNOR curated interactions for NUP155 Gene

Transcripts for NUP155 Gene

Unigene Clusters for NUP155 Gene

Nucleoporin 155kDa:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUP155 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^
SP1: -
SP2:
SP3:
SP4:

ExUns: 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b ^ 32 ^ 33 ^ 34 ^ 35a · 35b ^ 36a · 36b
SP1: - -
SP2: - -
SP3:
SP4:

Relevant External Links for NUP155 Gene

GeneLoc Exon Structure for
NUP155
ECgene alternative splicing isoforms for
NUP155

Expression for NUP155 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NUP155 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NUP155 Gene

This gene is overexpressed in Testis (x6.1).

Protein differential expression in normal tissues from HIPED for NUP155 Gene

This gene is overexpressed in Lymph node (11.9) and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NUP155 Gene



Protein tissue co-expression partners for NUP155 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NUP155 Gene:

NUP155

SOURCE GeneReport for Unigene cluster for NUP155 Gene:

Hs.547696

mRNA Expression by UniProt/SwissProt for NUP155 Gene:

O75694-NU155_HUMAN
Tissue specificity: Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expression patterns with NUP155: view

Orthologs for NUP155 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUP155 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUP155 34 35
  • 99.26 (n)
dog
(Canis familiaris)
Mammalia NUP155 34 35
  • 93.12 (n)
cow
(Bos Taurus)
Mammalia NUP155 34 35
  • 92.14 (n)
oppossum
(Monodelphis domestica)
Mammalia NUP155 35
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUP155 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nup155 34 16 35
  • 87.58 (n)
rat
(Rattus norvegicus)
Mammalia Nup155 34
  • 87.46 (n)
chicken
(Gallus gallus)
Aves NUP155 34 35
  • 78.55 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 84 (a)
OneToMany
-- 35
  • 82 (a)
OneToMany
-- 35
  • 78 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia nup155 34
  • 72.66 (n)
Str.16474 34
African clawed frog
(Xenopus laevis)
Amphibia nup155-prov 34
zebrafish
(Danio rerio)
Actinopterygii nup155 34 35
  • 65.87 (n)
zgc55435 34
fruit fly
(Drosophila melanogaster)
Insecta Nup154 36 34 35
  • 45.59 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007999 34
  • 23.54 (n)
worm
(Caenorhabditis elegans)
Secernentea npp-8 34 35
  • 41.63 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NUP157 35
  • 18 (a)
OneToMany
NUP170 35 37
  • 18 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons NUP155 34
  • 44 (n)
rice
(Oryza sativa)
Liliopsida Os06g0305200 34
  • 44.31 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.412 34
Species where no ortholog for NUP155 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUP155 Gene

ENSEMBL:
Gene Tree for NUP155 (if available)
TreeFam:
Gene Tree for NUP155 (if available)

Paralogs for NUP155 Gene

Pseudogenes.org Pseudogenes for NUP155 Gene

genes like me logo Genes that share paralogs with NUP155: view

No data available for Paralogs for NUP155 Gene

Variants for NUP155 Gene

Sequence variations from dbSNP and Humsavar for NUP155 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs587777339 Atrial fibrillation, familial, 15 (ATFB15) [MIM:615770], Pathogenic 37,341,164(+) GTAAG(C/T)GGACA nc-transcript-variant, reference, missense
rs10045656 -- 37,363,204(+) tcagc(A/G)tgctc intron-variant
rs10051872 -- 37,324,721(+) ttaat(C/T)ttatt intron-variant
rs10053828 -- 37,353,260(+) tatat(A/T)tatac intron-variant
rs10054453 -- 37,361,978(+) tgcca(C/T)gtgag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUP155 Gene

Variant ID Type Subtype PubMed ID
nsv830265 CNV loss 17160897
nsv597845 CNV gain 21841781
nsv597844 CNV gain 21841781
nsv597823 CNV gain 21841781
nsv525478 CNV loss 19592680
nsv471012 CNV gain 18288195
nsv329973 CNV deletion 16902084
nsv328371 CNV deletion 16902084
nsv1136992 CNV deletion 24896259
nsv1131889 CNV deletion 24896259
nsv1030797 CNV gain 25217958
esv3604734 CNV gain 21293372
esv3604731 CNV gain 21293372
esv3604728 CNV gain 21293372
esv3575837 CNV gain 25503493
esv3565822 CNV deletion 23714750
esv2730083 CNV deletion 23290073
esv2671337 CNV deletion 23128226
esv2496620 CNV deletion 19546169
esv2270645 CNV deletion 18987734
dgv9722n54 CNV loss 21841781
dgv5634n100 CNV gain 25217958
dgv29e194 CNV deletion 18987734

Variation tolerance for NUP155 Gene

Residual Variation Intolerance Score: 1.07% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.26; 40.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUP155 Gene

Human Gene Mutation Database (HGMD)
NUP155
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUP155

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUP155 Gene

Disorders for NUP155 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NUP155 Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
atrial fibrillation 15
  • atrial fibrillation, familial, 15
familial atrial fibrillation
  • atrial fibrillation, familial, 1
atrial fibrillation
  • a-fib
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

NU155_HUMAN
  • Atrial fibrillation, familial, 15 (ATFB15) [MIM:615770]: A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. {ECO:0000269 PubMed:19070573}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for NUP155

Genetic Association Database (GAD)
NUP155
Human Genome Epidemiology (HuGE) Navigator
NUP155
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUP155
genes like me logo Genes that share disorders with NUP155: view

No data available for Genatlas for NUP155 Gene

Publications for NUP155 Gene

  1. Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex. (PMID: 15703211) Hawryluk-Gara L.A. … Wozniak R.W. (Mol. Biol. Cell 2005) 3 4 22 64
  2. The mRNA export factor human Gle1 interacts with the nuclear pore complex protein Nup155. (PMID: 14645504) Rayala H.J. … Wente S.R. (Mol. Cell. Proteomics 2004) 3 4 22 64
  3. Localization of a human nucleoporin 155 gene (NUP155) to the 5p13 region and cloning of its cDNA. (PMID: 10191094) Zhang X. … Bolund L. (Genomics 1999) 2 3 4 64
  4. Mutation in nuclear pore component NUP155 leads to atrial fibrillation and early sudden cardiac death. (PMID: 19070573) Zhang X. … Wang Q.K. (Cell 2008) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for NUP155 Gene

Sources for NUP155 Gene

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