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Aliases for NUP155 Gene

Aliases for NUP155 Gene

  • Nucleoporin 155kDa 2 3
  • 155 KDa Nucleoporin 3 4
  • Nucleoporin 155kD 2 3
  • KIAA0791 4 6
  • Nuclear Pore Complex Protein Nup155 3
  • Nucleoporin Nup155 4
  • ATFB15 3
  • N155 3

External Ids for NUP155 Gene

Previous GeneCards Identifiers for NUP155 Gene

  • GC05M037473
  • GC05M038358
  • GC05M037290
  • GC05M037337
  • GC05M037327

Summaries for NUP155 Gene

Entrez Gene Summary for NUP155 Gene

  • Nucleoporins are proteins that play an important role in the assembly and functioning of the nuclear pore complex (NPC) which regulates the movement of macromolecules across the nuclear envelope (NE). The protein encoded by this gene plays a role in the fusion of NE vesicles and formation of the double membrane NE. The protein may also be involved in cardiac physiology and may be associated with the pathogenesis of atrial fibrillation. Alternative splicing results in multiple transcript variants of this gene. A pseudogene associated with this gene is located on chromosome 6. [provided by RefSeq, May 2013]

GeneCards Summary for NUP155 Gene

NUP155 (Nucleoporin 155kDa) is a Protein Coding gene. Diseases associated with NUP155 include atrial fibrillation 15 and atrial fibrillation. Among its related pathways are Disease and Cell Cycle, Mitotic. GO annotations related to this gene include transporter activity and structural constituent of nuclear pore.

UniProtKB/Swiss-Prot for NUP155 Gene

  • Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport.

Gene Wiki entry for NUP155 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP155 Gene

Genomics for NUP155 Gene

Regulatory Elements for NUP155 Gene

Genomic Location for NUP155 Gene

Start:
37,288,137 bp from pter
End:
37,371,181 bp from pter
Size:
83,045 bases
Orientation:
Minus strand

Genomic View for NUP155 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUP155 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP155 Gene

Proteins for NUP155 Gene

  • Protein details for NUP155 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75694-NU155_HUMAN
    Recommended name:
    Nuclear pore complex protein Nup155
    Protein Accession:
    O75694
    Secondary Accessions:
    • Q9UBE9
    • Q9UFL5

    Protein attributes for NUP155 Gene

    Size:
    1391 amino acids
    Molecular mass:
    155199 Da
    Quaternary structure:
    • Interacts with GLE1. Able to form a heterotrimer with GLE1 and NUPL2 in vitro. Forms a complex with NUP53, NUP93, NUP205 and lamin B.
    SequenceCaution:
    • Sequence=AAD52966.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA34511.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for NUP155 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUP155 Gene

Proteomics data for NUP155 Gene at MOPED

Post-translational modifications for NUP155 Gene

  • Disulfide-linked to NUP62. The the inner channel of the NPC has a different redox environment from the cytoplasm and allows the formation of interchain disulfide bonds between some nucleoporins, the significant increase of these linkages upon oxidative stress reduces the permeability of the NPC (By similarity).
  • Phosphorylated. Phosphorylation and dephosphorylation may be important for the function of NUP155 and may play a role in the reversible disassembly of the nuclear pore complex during mitosis (By similarity).
  • Ubiquitination at Lys297, Lys340, Lys740, Lys824, Lys906, Lys973, Lys1147, and Lys1308
  • Glycosylation at Ser526
  • Modification sites at PhosphoSitePlus

Other Protein References for NUP155 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for NUP155

No data available for DME Specific Peptides for NUP155 Gene

Domains for NUP155 Gene

Suggested Antigen Peptide Sequences for NUP155 Gene

Graphical View of Domain Structure for InterPro Entry

O75694

UniProtKB/Swiss-Prot:

NU155_HUMAN :
  • O75694
Family:
  • Belongs to the non-repetitive/WGA-negative nucleoporin family.
genes like me logo Genes that share domains with NUP155: view

No data available for Gene Families for NUP155 Gene

Function for NUP155 Gene

Molecular function for NUP155 Gene

GENATLAS Biochemistry:
nucleoporin 155 with two alternative spliced isoforms,ubiquitously expressed,component of nuclear pore complexes,involved in nucleocytoplasmic transport maybe involved in mental and developmental retardation in patients with 5p13 deletion
UniProtKB/Swiss-Prot Function:
Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport.

Gene Ontology (GO) - Molecular Function for NUP155 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity TAS 10191094
GO:0005515 protein binding IPI 25416956
GO:0017056 structural constituent of nuclear pore IEA --
genes like me logo Genes that share ontologies with NUP155: view

Phenotypes for NUP155 Gene

genes like me logo Genes that share phenotypes with NUP155: view

Animal Model Products

miRNA for NUP155 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NUP155

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NUP155 Gene

Localization for NUP155 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP155 Gene

Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note=In mitosis, assumes a diffuse cytoplasmic distribution probably as a monomer, before reversing back into a punctate nuclear surface localization at the end of mitosis. {ECO:0000250 UniProtKB:P37199}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUP155 Gene COMPARTMENTS Subcellular localization image for NUP155 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 2
endoplasmic reticulum 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NUP155 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope TAS --
GO:0005643 nuclear pore IEA --
GO:0016020 membrane IDA 19946888
GO:0031965 nuclear membrane IEA --
genes like me logo Genes that share ontologies with NUP155: view

Pathways for NUP155 Gene

SuperPathways for NUP155 Gene

genes like me logo Genes that share pathways with NUP155: view

Pathways by source for NUP155 Gene

42 Reactome pathways for NUP155 Gene
1 KEGG pathway for NUP155 Gene

Gene Ontology (GO) - Biological Process for NUP155 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0005975 carbohydrate metabolic process TAS --
GO:0006406 mRNA export from nucleus IEA --
GO:0006606 protein import into nucleus IEA --
GO:0006913 nucleocytoplasmic transport --
genes like me logo Genes that share ontologies with NUP155: view

Transcripts for NUP155 Gene

Unigene Clusters for NUP155 Gene

Nucleoporin 155kDa:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NUP155

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUP155 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^
SP1: -
SP2:
SP3:
SP4:

ExUns: 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b ^ 32 ^ 33 ^ 34 ^ 35a · 35b ^ 36a · 36b
SP1: - -
SP2: - -
SP3:
SP4:

Relevant External Links for NUP155 Gene

GeneLoc Exon Structure for
NUP155
ECgene alternative splicing isoforms for
NUP155

Expression for NUP155 Gene

mRNA expression in normal human tissues for NUP155 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NUP155 Gene

This gene is overexpressed in Testis (6.1).

Protein differential expression in normal tissues for NUP155 Gene

This gene is overexpressed in Lymph node (11.9) and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUP155 Gene

SOURCE GeneReport for Unigene cluster for NUP155 Gene Hs.547696

mRNA Expression by UniProt/SwissProt for NUP155 Gene

O75694-NU155_HUMAN
Tissue specificity: Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas
genes like me logo Genes that share expressions with NUP155: view

Expression partners for NUP155 Gene

In Situ Assay Products

Orthologs for NUP155 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUP155 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NUP155 35
  • 92.14 (n)
  • 96.26 (a)
NUP155 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUP155 35
  • 93.12 (n)
  • 96.69 (a)
NUP155 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nup155 35
  • 87.58 (n)
  • 94.96 (a)
Nup155 16
Nup155 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NUP155 35
  • 99.26 (n)
  • 98.97 (a)
NUP155 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nup155 35
  • 87.46 (n)
  • 93.81 (a)
oppossum
(Monodelphis domestica)
Mammalia NUP155 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUP155 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUP155 35
  • 78.55 (n)
  • 86.09 (a)
NUP155 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 78 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
-- 36
  • 84 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia nup155 35
  • 72.66 (n)
  • 79.99 (a)
Str.16474 35
African clawed frog
(Xenopus laevis)
Amphibia nup155-prov 35
zebrafish
(Danio rerio)
Actinopterygii nup155 35
  • 65.87 (n)
  • 73.59 (a)
zgc55435 35
nup155 36
  • 73 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Nup154 37
  • 31 (a)
Nup154 35
  • 45.59 (n)
  • 35.48 (a)
Nup154 36
  • 33 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007999 35
  • 23.54 (n)
  • 6.07 (a)
worm
(Caenorhabditis elegans)
Secernentea npp-8 35
  • 41.63 (n)
  • 29.73 (a)
npp-8 36
  • 27 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NUP157 36
  • 18 (a)
OneToMany
NUP170 36
  • 18 (a)
OneToMany
NUP170 38
thale cress
(Arabidopsis thaliana)
eudicotyledons NUP155 35
  • 44 (n)
  • 30.98 (a)
rice
(Oryza sativa)
Liliopsida Os06g0305200 35
  • 44.31 (n)
  • 31.36 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.412 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToOne
Species with no ortholog for NUP155:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUP155 Gene

ENSEMBL:
Gene Tree for NUP155 (if available)
TreeFam:
Gene Tree for NUP155 (if available)

Paralogs for NUP155 Gene

Pseudogenes.org Pseudogenes for NUP155 Gene

genes like me logo Genes that share paralogs with NUP155: view

No data available for Paralogs for NUP155 Gene

Variants for NUP155 Gene

Sequence variations from dbSNP and Humsavar for NUP155 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs53429 -- 37,310,663(+) AGAGA(A/G)GCAAT intron-variant, synonymous-codon, reference
rs56401 -- 37,326,696(+) TGTGA(C/G)AGTCT intron-variant
rs56402 -- 37,327,123(+) catat(A/G)acaca intron-variant
rs125682 -- 37,337,045(-) CTCCT(A/G)AATAG intron-variant
rs125684 -- 37,301,350(+) AATTT(C/T)CCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUP155 Gene

Variant ID Type Subtype PubMed ID
nsv525478 CNV Loss 19592680
nsv881511 CNV Gain 21882294
nsv830265 CNV Loss 17160897
nsv880406 CNV Gain 21882294
dgv6037n71 CNV Gain 21882294
nsv881512 CNV Gain 21882294
nsv328371 CNV Loss 16902084
esv2496620 CNV Deletion 19546169
dgv29e194 CNV Deletion 18987734
esv2730083 CNV Deletion 23290073
esv2671337 CNV Deletion 23128226
nsv329973 CNV Loss 16902084
nsv881076 CNV Gain 21882294
esv2270645 CNV Deletion 18987734
nsv471012 CNV Gain 18288195

Relevant External Links for NUP155 Gene

HapMap Linkage Disequilibrium report
NUP155
Human Gene Mutation Database (HGMD)
NUP155

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUP155 Gene

Disorders for NUP155 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for NUP155 Gene in MalaCards »

(3) Diseases for NUP155 Gene including...

UniProtKB/Swiss-Prot

NU155_HUMAN
  • Atrial fibrillation, familial, 15 (ATFB15) [MIM:615770]: A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. {ECO:0000269 PubMed:19070573}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for NUP155

Genetic Association Database (GAD)
NUP155
Human Genome Epidemiology (HuGE) Navigator
NUP155
genes like me logo Genes that share disorders with NUP155: view

No data available for OMIM , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for NUP155 Gene

Publications for NUP155 Gene

  1. The mRNA export factor human Gle1 interacts with the nuclear pore complex protein Nup155. (PMID: 14645504) Rayala H.J. … Wente S.R. (Mol. Cell. Proteomics 2004) 3 4 23
  2. Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex. (PMID: 15703211) Hawryluk-Gara L.A. … Wozniak R.W. (Mol. Biol. Cell 2005) 3 4 23
  3. Localization of a human nucleoporin 155 gene (NUP155) to the 5p13 region and cloning of its cDNA. (PMID: 10191094) Zhang X. … Bolund L. (Genomics 1999) 2 3 4
  4. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for NUP155 Gene

Sources for NUP155 Gene

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