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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NUP153 Gene

protein-coding   GIFtS: 61
GCID: GC06M017559

Nucleoporin 153kDa

(Previous name: nucleoporin 153kD)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nucleoporin 153kDa1 2     HNUP1532
Nucleoporin Nup1532 3     N1532
153 KDa Nucleoporin2 3     Nuclear Pore Complex Protein Hnup1532
Nucleoporin 153kD1     Nuclear Pore Complex Protein Nup1532

External Ids:    HGNC: 80621   Entrez Gene: 99722   Ensembl: ENSG000001247897   OMIM: 6039485   UniProtKB: P497903   

Export aliases for NUP153 gene to outside databases

Previous GC identifers: GC06M017672 GC06M017723


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NUP153 Gene:
Nuclear pore complexes regulate the transport of macromolecules between the nucleus and cytoplasm. They are
composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family.
Nucleoporins are glycoproteins found in nuclear pores and contain characteristic pentapeptide XFXFG repeats as
well as O-linked N-acetylglucosamine residues oriented towards the cytoplasm. The protein encoded by this gene
has three distinct domains: a N-terminal region containing a pore targeting and an RNA-binding domain domain, a
central region containing multiple zinc finger motifs, and a C-terminal region containing multiple XFXFG repeats.
Alternative splicing results in multiple transcript variants of this gene. (provided by RefSeq, May 2013)

GeneCards Summary for NUP153 Gene: 
NUP153 (nucleoporin 153kDa) is a protein-coding gene. Diseases associated with NUP153 include hemophagocytic lymphohistiocytosis, and influenza, and among its related super-pathways are Interactions of Rev with host cellular proteins and HIV Life Cycle. GO annotations related to this gene include structural constituent of nuclear pore and transporter activity.

UniProtKB/Swiss-Prot: NU153_HUMAN, P49790
Function: Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear
envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal
nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced
mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing
constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the
nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to
the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC)

Gene Wiki entry for NUP153 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NUP153 gene promoter:
         AhR   TBP   HFH-3   FOXD3   POU6F1 (c2)   LCR-F1   C/EBPalpha   FOXI1   IRF-2   FOXC1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NUP153 promoter sequence
   Search SABiosciences Chromatin IP Primers for NUP153

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUP153


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.3   Ensembl cytogenetic band:  6p22.3   HGNC cytogenetic band: 6p22.3

NUP153 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUP153 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M017559:  view genomic region     (about GC identifiers)

Start:
17,615,269 bp from pter      End:
17,706,818 bp from pter
Size:
91,550 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NU153_HUMAN, P49790 (See protein sequence)
Recommended Name: Nuclear pore complex protein Nup153  
Size: 1475 amino acids; 153938 Da
Cofactor: Binds at least 4 zinc ions per subunit (By similarity)
Subunit: Interacts with RAN; the interaction occurs in a GTP- and GDP-independent manner (By similarity). Part of
the nuclear pore complex (NPC). Interacts with TPR (via coiled coil region); the interaction is direct and
provides a link between the core structure and the TPR-containing nuclear basket of the nuclear pore complex
(NPC). Interacts with HIV-1 integrase; this interaction might play a role in nuclear import of HIV
pre-integration complex. Interacts with hepatitis B virus capsid protein; this interaction probably plays a role
in nuclear import of HBV genome. Interacts with C11orf73/Hikeshi, SENP2 and XPO5
Subcellular location: Nucleus. Nucleus membrane. Nucleus, nuclear pore complex. Note=Tightly associated with the
nuclear membrane and lamina (By similarity). Localized to the nucleoplasmic side of the nuclear pore complex
(NPC) core structure, forming a fibrous structure called the nuclear basket. Dissociates from the NPC structure
early during prophase of mitosis. Integrated in the newly assembled nuclear envelope of postmitotic cells early
in G1. Colocalized with NUP98 and TPR to the nuclear basket at the nucleoplasmic side of the NPC. Detected in
diffuse and discrete intranuclear foci. Remained localized to the nuclear membrane after poliovirus (PV)
infection
4 PDB 3D structures from and Proteopedia for NUP153:
2EBQ (3D)        2EBR (3D)        2EBV (3D)        2GQE (3D)    
Secondary accessions: Q5T9I7

Explore the universe of human proteins at neXtProt for NUP153: NX_P49790

Explore proteomics data for NUP153 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated in interphase, hyperphosphorylated during mitosis. May play a role in the reversible disassembly of
    the nuclear pore complex during mitosis (By similarity)
  • UniProtKB: Proteolytically degraded after poliovirus (PV) infection; degradation is partial and NCP- and TPR-binding domains
    withstand degradation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P49790

  • NUP153 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NUP153 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001265138.1  NP_001265139.1  NP_005115.2  

    ENSEMBL proteins: 
     ENSP00000262077   ENSP00000444029  
    Reactome Protein details: P49790
    Human Recombinant Protein Products for NUP153: 
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    Cloud-Clone Corp. Proteins for NUP153 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005643nuclear pore IDA12802065
    GO:0005654nucleoplasm TAS--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0031965nuclear membrane IDA--

    NUP153 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for NUP153


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR026054 Nucleoporin
     IPR013913 Nucleoporin_Nup153
     IPR001876 Znf_RanBP2
     IPR018892 Retro-transposon_transp_CS

    Graphical View of Domain Structure for InterPro Entry P49790

    ProtoNet protein and cluster: P49790

    2 Blocks protein domains:
    IPB001876 Zn-finger
    IPB013913 Nucleoporin Nup153-like


    UniProtKB/Swiss-Prot: NU153_HUMAN, P49790
    Domain: Contains F-X-F-G repeats
    Similarity: Belongs to the NUP153 family
    Similarity: Contains 4 RanBP2-type zinc fingers


    NUP153 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NU153_HUMAN, P49790
    Function: Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear
    envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal
    nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced
    mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing
    constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the
    nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to
    the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC)

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005215transporter activity TAS8110839
    GO:0005487nucleocytoplasmic transporter activity IDA--
    GO:0005515protein binding IPI11896061
    GO:0008270zinc ion binding IEA--
         
    NUP153 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for NUP153:
     Cell cycle / mitosis defect  Decreased p24 protein expressi  Increased homologous recombina  Nucleoplasmic pre-40S maturati 
     Upregulation of Wnt/beta-caten  Wnt reporter upregulated 

    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NUP153 
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    SwitchGear 3'UTR luciferase reporter plasmidNUP153 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NUP153 About   (see all 13)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Regulation of Glucokinase by Glucokinase Regulatory Protein
    Rev-mediated nuclear export of HIV RNA0.94
    Hexose transport0.87
    Nuclear import of Rev protein0.94
    Regulation of Glucokinase by Glucokinase Regulatory Protein0.82
    Interactions of Rev with host cellular proteins0.94
    Nuclear Pore Complex (NPC) Disassembly0.77
    Vpr-mediated nuclear import of PICs0.91
    Nuclear Envelope Breakdown0.77
    2HIV Life Cycle
    HIV Life Cycle0.92
    HIV Infection0.61
    Late Phase of HIV Life Cycle0.92
    Host Interactions of HIV factors0.60
    3Interferon Signaling
    Interferon Signaling0.61
    Antiviral mechanism by IFN-stimulated genes0.42
    Cytokine Signaling in Immune system0.61
    ISG15 antiviral mechanism0.42
    4M Phase
    M Phase0.88
    Mitotic M-M/G1 phases0.88
    5Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for NUP153
        TGF-beta Receptor Signaling Pathway
    Regulation of cytoplasmic and nuclear SMAD2/3 signaling

    5/29        Reactome Pathways for NUP153 (see all 29)
        Antiviral mechanism by IFN-stimulated genes
    Late Phase of HIV Life Cycle
    Metabolism
    Cell Cycle
    M Phase


    1         Kegg Pathway  (Kegg details for NUP153):
        RNA transport


    NUP153 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NUP153

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/662 Interacting proteins for NUP153 (P497902, 3 ENSP000002620774) via UniProtKB, MINT, STRING, and/or I2D (see all 662)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EPHB2P293232, 3, ENSP000003637634MINT-4300391 MINT-4300355 I2D: score=1 STRING: ENSP00000363763
    KPNB1Q149742, 3, ENSP000002901584MINT-7945693 I2D: score=3 STRING: ENSP00000290158
    NXF1Q9UBU92, 3, ENSP000002941724MINT-15627 I2D: score=3 STRING: ENSP00000294172
    KPNA2P522922, 3, ENSP000003324554MINT-7945693 I2D: score=1 STRING: ENSP00000332455
    LMNAP025452, 3, ENSP000003572834MINT-7945693 MINT-7893777 I2D: score=1 STRING: ENSP00000357283
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006913nucleocytoplasmic transport IDA--
    GO:0007077mitotic nuclear envelope disassembly TAS--
    GO:0008645hexose transport TAS--

    NUP153 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NUP153 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NUP153 (NU153)

    3 Novoseek inferred chemical compound relationships for NUP153 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 27.4 4 16314393 (2), 8110839 (1)
    actinomycin d 26.4 1 9847314 (1)
    pyruvate 15 1 8794857 (1)

    Search CenterWatch for drugs/clinical trials and news about NUP153 / NU153

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NUP153 gene (3 alternative transcripts): 
    NM_001278209.1  NM_001278210.1  NM_005124.3  

    Unigene Clusters for NUP153:

    Nucleoporin 153kDa
    Hs.601591  [show with all ESTs], Hs.718703  [show with all ESTs]
    Unigene Representative Sequences: AB210024, BM913096
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262077(uc003ncd.1 uc011dje.1 uc010jpl.1) ENST00000537253

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    BC035502.2 BC046172.1 

    16 DOTS entries:

    DT.446927  DT.434816  DT.99971020  DT.102824068  DT.121337199  DT.441584  DT.95148921  DT.95276137 
    DT.100668485  DT.100736910  DT.100783295  DT.121337101  DT.121337117  DT.121337129  DT.95276139  DT.97823514 

    24/284 AceView cDNA sequences (see all 284):

    BM452707 BE302064 BF514609 AI674110 BQ003194 AI334024 T17448 AI633612 
    AI076481 BU625075 BC052965 AL043771 AW243855 AI636641 AA401272 BE676763 
    CA419219 AI654426 T09409 AI246397 AL043523 NM_005124 BE503034 AI652148 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for NUP153 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 22a · 22b ^ 23a · 23b ^ 24
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for NUP153

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NUP153 expression in normal human tissues (normalized intensities)      NUP153 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCCTTAGAA
    NUP153 Expression
    About this image


    NUP153 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/33 selected tissues (see all 33) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See NUP153 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NUP153

    SOURCE GeneReport for Unigene clusters: Hs.601591 Hs.718703
        SABiosciences Custom PCR Arrays for NUP153
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NUP153 gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nup1531 , 5 nucleoporin 1531, 5 86.38(n)1
    83.28(a)1
      13 (24.30 cM)5
    2182101  NM_175749.21  NP_786925.21 
     466799055 
    chicken
    (Gallus gallus)
    Aves NUP1531 nucleoporin 153kDa 70.31(n)
    66.76(a)
      420848  XM_418937.3  XP_418937.3 
    lizard
    (Anolis carolinensis)
    Reptilia NUP1536
    Uncharacterized protein
    57(a)
    1 ↔ 1
    4(59114621-59142860)
    African clawed frog
    (Xenopus laevis)
    Amphibia NUP1532 nucleoporin Nup153 76.36(n)    AF434196.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd23d092 Transcribed sequence with weak similarity to protein more 88.52(n)    57057051 
    fruit fly
    (Drosophila melanogaster)
    Insecta Nup1531 Nucleoporin 153 39.09(n)
    30.57(a)
      32630  NM_001103532.2  NP_001097002.1 
    worm
    (Caenorhabditis elegans)
    Secernentea npp-76
    Protein NPP-7
    15(a)
    1 ↔ 1
    I(5691838-5697450)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NUP16
    Nuclear pore complex (NPC) subunit, involved in pr...
    20(a)
    1 ↔ 1
    XV(507948-511178)


    ENSEMBL Gene Tree for NUP153 (if available)
    TreeFam Gene Tree for NUP153 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NUP153 gene
    1 SIMAP similar gene for NUP153 using alignment to 3 protein entries:     NU153_HUMAN (see all proteins):
    NUP153 variant protein

    NUP153 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2212 SNPs in NUP153 are shown (see all 2212)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0465594
    ----see VAR_0465592 T A mis40--------
    rs715367431,2
    C--17593605(+) AAAAA-/AAAA  
      
    /AAAAA
    GTACT
    1 -- int11NA 2
    rs676847051,2
    C--17612986(+) TTTTT-/T/TT  
            
    GAGAT
    1 -- int11NA 2
    rs2015258201,2
    --17614868(+) ACTGG-/GCGGGGG 1 -- ds50010--------
    rs93710051,2
    C,A--17614870(+) CTGGGG/CGGGGG 1 -- ds50014Minor allele frequency- C:0.48NA CSA WA 241
    rs93500501,2
    --17614873(+) gggggG/Tggggg 1 -- ds50010--------
    rs1853374321,2
    --17614882(+) GGGAGG/TGCAGT 1 -- ds50010--------
    rs93500511,2
    C,F,A,H--17614952(+) CAAGAC/ACTTTA 1 -- ds500123Minor allele frequency- A:0.45NA NS EA WA CSA 2474
    rs787846241,2
    C,F--17615041(+) AAGGTA/GCCTAA 1 -- ds50011Minor allele frequency- G:0.04WA 118
    rs1463591811,2
    --17615208(+) TATTTC/TACAAA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for NUP153 (17615269 - 17706818 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for NUP153:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv268526CNV Insertion20981092
    nsv883456CNV Gain21882294
    nsv883457CNV Gain21882294
    nsv830596CNV Gain17160897
    nsv883458CNV Gain21882294
    nsv516012CNV Gain+Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603948    OMIM disorders: --

    5 diseases for NUP153:    About MalaCards
    hemophagocytic lymphohistiocytosis    influenza    hepatitis b    hepatitis
    breast cancer


    NUP153 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for NUP153 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 1.21 1 19369352 (1)

    Genetic Association Database (GAD): NUP153
    Human Genome Epidemiology (HuGE) Navigator: NUP153 (2 documents)

    Export disorders for NUP153 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NUP153 gene, integrated from 9 sources (see all 133):
    (articles sorted by number of sources associating them with NUP153)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence analysis of a cDNA encoding a human nuclear pore complex protein, hnup153. (PubMed id 8110839)1, 2, 3, 9 McMorrow I.... Burke B. (1994)
    2. Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket. (PubMed id 15229283)1, 2, 9 Krull S....Cordes V.C. (2004)
    3. Integrase interacts with nucleoporin NUP153 to mediat e the nuclear import of human immunodeficiency virus type 1. (PubMed id 19369352)1, 2, 9 Woodward C.L....Chow S.A. (2009)
    4. Nucleoporin 153 arrests the nuclear import of hepatiti s B virus capsids in the nuclear basket. (PubMed id 20126445)1, 2 Schmitz A....Kann M. (2010)
    5. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (2008)
    6. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    8. Direct interaction with nup153 mediates binding of Tpr to the periphery of the nuclear pore complex. (PubMed id 12802065)1, 2 Hase M.E. and Cordes V.C. (2003)
    9. Tpr is localized within the nuclear basket of the por e complex and has a role in nuclear protein export. (PubMed id 11839768)1, 2 Frosst P....Gerace L. (2002)
    10. Exportin-5, a novel karyopherin, mediates nuclear export of double- stranded RNA binding proteins. (PubMed id 11777942)1, 2 Brownawell A.M. and Macara I.G. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9972 HGNC: 8062 AceView: NUP153 Ensembl:ENSG00000124789 euGenes: HUgn9972
    ECgene: NUP153 Kegg: 9972 H-InvDB: NUP153

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NUP153 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NUP153 gene:
    Search GeneIP for patents involving NUP153

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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