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NUP153 Gene

protein-coding   GIFtS: 62
GCID: GC06M017615

Nucleoporin 153kDa

(Previous name: nucleoporin 153kD)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nucleoporin 153kDa1 2     HNUP1532
Nucleoporin Nup1532 3     N1532
153 KDa Nucleoporin2 3     Nuclear Pore Complex Protein Hnup1532
Nucleoporin 153kD1     Nuclear Pore Complex Protein Nup1532

External Ids:    HGNC: 80621   Entrez Gene: 99722   Ensembl: ENSG000001247897   OMIM: 6039485   UniProtKB: P497903   

Export aliases for NUP153 gene to outside databases

Previous GC identifers: GC06M017672 GC06M017723 GC06M017559


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NUP153 Gene:
Nuclear pore complexes regulate the transport of macromolecules between the nucleus and cytoplasm. They are
composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family.
Nucleoporins are glycoproteins found in nuclear pores and contain characteristic pentapeptide XFXFG repeats as
well as O-linked N-acetylglucosamine residues oriented towards the cytoplasm. The protein encoded by this gene
has three distinct domains: a N-terminal region containing a pore targeting and an RNA-binding domain domain, a
central region containing multiple zinc finger motifs, and a C-terminal region containing multiple XFXFG repeats.
Alternative splicing results in multiple transcript variants of this gene. (provided by RefSeq, May 2013)

GeneCards Summary for NUP153 Gene:
NUP153 (nucleoporin 153kDa) is a protein-coding gene. GO annotations related to this gene include nucleocytoplasmic transporter activity and identical protein binding.

UniProtKB/Swiss-Prot: NU153_HUMAN, P49790
Function: Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear
envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal
nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced
mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing
constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the
nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to
the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC)

Gene Wiki entry for NUP153 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NUP153 gene promoter:
         AhR   TBP   HFH-3   FOXD3   POU6F1 (c2)   LCR-F1   C/EBPalpha   FOXI1   IRF-2   FOXC1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NUP153 promoter sequence
   Search Chromatin IP Primers for NUP153

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NUP153


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.3   Ensembl cytogenetic band:  6p22.3   HGNC cytogenetic band: 6p22.3

NUP153 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUP153 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M017615:  view genomic region     (about GC identifiers)

Start:
17,615,269 bp from pter      End:
17,706,818 bp from pter
Size:
91,550 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NU153_HUMAN, P49790 (See protein sequence)
Recommended Name: Nuclear pore complex protein Nup153  
Size: 1475 amino acids; 153938 Da
Cofactor: Binds at least 4 zinc ions per subunit (By similarity)
Subunit: Interacts with RAN; the interaction occurs in a GTP- and GDP-independent manner (By similarity). Part of
the nuclear pore complex (NPC). Interacts with TPR (via coiled coil region); the interaction is direct and
provides a link between the core structure and the TPR-containing nuclear basket of the nuclear pore complex
(NPC). Interacts with HIV-1 integrase; this interaction might play a role in nuclear import of HIV
pre-integration complex. Interacts with hepatitis B virus capsid protein; this interaction probably plays a role
in nuclear import of HBV genome. Interacts with C11orf73/Hikeshi, SENP2 and XPO5
4 PDB 3D structures from and Proteopedia for NUP153:
2EBQ (3D)        2EBR (3D)        2EBV (3D)        2GQE (3D)    
Secondary accessions: Q5T9I7

Explore the universe of human proteins at neXtProt for NUP153: NX_P49790

Explore proteomics data for NUP153 at MOPED

Post-translational modifications: 

  • Phosphorylated in interphase, hyperphosphorylated during mitosis. May play a role in the reversible disassembly of
    the nuclear pore complex during mitosis (By similarity)1
  • Proteolytically degraded after poliovirus (PV) infection; degradation is partial and NCP- and TPR-binding domains
    withstand degradation1
  • O-glycosylated during cytokinesis at sites identical or close to phosphorylation sites, this interferes with the
    phosphorylation status1
  • Ubiquitination2 at Lys15, Lys48, Lys263, Lys384, Lys960, Lys1148
  • Glycosylation2 at Ser534, Ser544, Ser908, Ser909, Ser1113, Thr1156
  • Modification sites at PhosphoSitePlus

  • See NUP153 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001265138.1  NP_001265139.1  NP_005115.2  

    ENSEMBL proteins: 
     ENSP00000262077   ENSP00000444029  
    Reactome Protein details: P49790

    NUP153 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for NUP153

     
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    NUP153 Assay Products:

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    Cloud-Clone Corp. ELISAs for NUP153
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    Search eBioscience for ELISAs for NUP153 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR026054 Nucleoporin
     IPR013913 Nucleoporin_Nup153
     IPR001876 Znf_RanBP2
     IPR018892 Retro-transposon_transp_CS

    Graphical View of Domain Structure for InterPro Entry P49790

    ProtoNet protein and cluster: P49790

    2 Blocks protein domains:
    IPB001876 Zn-finger
    IPB013913 Nucleoporin Nup153-like


    UniProtKB/Swiss-Prot: NU153_HUMAN, P49790
    Domain: Contains F-X-F-G repeats
    Similarity: Belongs to the NUP153 family
    Similarity: Contains 4 RanBP2-type zinc fingers


    Find genes that share domains with NUP153           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NU153_HUMAN, P49790
    Function: Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear
    envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal
    nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced
    mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing
    constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the
    nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to
    the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC)

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005215transporter activity TAS8110839
    GO:0005487nucleocytoplasmic transporter activity IDA--
    GO:0005515protein binding IPI11896061
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with NUP153           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for NUP153:
     Cell cycle / mitosis defect  Decreased p24 protein expressi  Increased homologous recombina  Nucleoplasmic pre-40S maturati 
     Upregulation of Wnt/beta-caten  Wnt reporter upregulated 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NUP153
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NUP153
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NUP153

    miRNA
    Products:
        
    miRTarBase miRNAs that target NUP153:
    hsa-mir-330-3p (MIRT043842), hsa-mir-744-5p (MIRT037471), hsa-let-7b-5p (MIRT052022), hsa-mir-93-5p (MIRT048835), hsa-mir-26b-5p (MIRT030167), hsa-mir-23a-3p (MIRT050446), hsa-mir-106b-3p (MIRT038549), hsa-mir-374b-5p (MIRT016069)

    Block miRNA regulation of human, mouse, rat NUP153 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NUP153 (see all 54):
    hsa-miR-361-5p hsa-miR-429 hsa-miR-513a-5p hsa-miR-548k hsa-let-7a-2* hsa-miR-29b-1* hsa-miR-3167 hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidNUP153 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat NUP153

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: NUP153 (NM_005124)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUP153

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUP153


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NU153_HUMAN, P49790: Nucleus. Nucleus membrane. Nucleus, nuclear pore complex. Note=Tightly associated with the
    nuclear membrane and lamina (By similarity). Localized to the nucleoplasmic side of the nuclear pore complex
    (NPC) core structure, forming a fibrous structure called the nuclear basket. Dissociates from the NPC structure
    early during prophase of mitosis. Integrated in the newly assembled nuclear envelope of postmitotic cells early
    in G1. Colocalized with NUP98 and TPR to the nuclear basket at the nucleoplasmic side of the NPC. Detected in
    diffuse and discrete intranuclear foci. Remained localized to the nuclear membrane after poliovirus (PV)
    infection
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005643nuclear pore IDA12802065
    GO:0005654nucleoplasm TAS--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0031965nuclear membrane IDA--

    Find genes that share ontologies with NUP153           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NUP153 About   (see all 16)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Regulation of Glucokinase by Glucokinase Regulatory Protein
    Transport of the SLBP Dependant Mature mRNA0.92
    Export of Viral Ribonucleoproteins from Nucleus0.88
    Transport of Mature mRNAs Derived from Intronless Transcripts0.92
    Transport of Ribonucleoproteins into the Host Nucleus0.88
    Transport of the SLBP independent Mature mRNA0.91
    Regulation of Glucokinase by Glucokinase Regulatory Protein0.87
    Nuclear import of Rev protein0.91
    Glucose transport0.87
    2HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    Host Interactions of HIV factors0.60
    3Interferon Signaling
    Interferon Signaling0.59
    ISG15 antiviral mechanism0.42
    Cytokine Signaling in Immune system0.59
    Antiviral mechanism by IFN-stimulated genes0.42
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    5Transport of Mature Transcript to Cytoplasm
    Transport of Mature Transcript to Cytoplasm0.93
    Transport of Mature mRNA derived from an Intron-Containing Transcript0.93


    Find genes that share SuperPaths with NUP153           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for NUP153
        TGF-beta Receptor Signaling Pathway
    Regulation of cytoplasmic and nuclear SMAD2/3 signaling

    Selected Reactome Pathways for NUP153 (see all 6)
        Rev-mediated nuclear export of HIV RNA
    Regulation of Glucokinase by Glucokinase Regulatory Protein
    Nuclear import of Rev protein
    Nuclear Pore Complex (NPC) Disassembly
    Vpr-mediated nuclear import of PICs


    1 Kegg Pathway  (Kegg details for NUP153):
        RNA transport

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NUP153
    Interactions:

        GeneGlobe Interaction Network for NUP153

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NUP153 (P497901, 2, 3 ENSP000002620774) via UniProtKB, MINT, STRING, and/or I2D (see all 726)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NUP153P497901, 2EBI-286779,EBI-286779 MINT-8430351 MINT-8430381 MINT-8430398 MINT-8430367
    NXF1Q9UBU92, 3, ENSP000002941724MINT-15627 I2D: score=3 STRING: ENSP00000294172
    NUP62P371982, 3, ENSP000003055034MINT-4301750 I2D: score=2 STRING: ENSP00000305503
    KPNA2P522922, 3, ENSP000003324554MINT-7945693 I2D: score=1 STRING: ENSP00000332455
    EPHB2P293231, 2, 3, ENSP000003637634EBI-286779,EBI-1059294 MINT-4300391 MINT-4300355 I2D: score=1 STRING: ENSP00000363763
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006913nucleocytoplasmic transport ----
    GO:0007077mitotic nuclear envelope disassembly TAS--
    GO:0008645hexose transport TAS--

    Find genes that share ontologies with NUP153           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NUP153 (NU153)

    3 Novoseek inferred chemical compound relationships for NUP153 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 27.4 4 16314393 (2), 8110839 (1)
    actinomycin d 26.4 1 9847314 (1)
    pyruvate 15 1 8794857 (1)



    Find genes that share compounds with NUP153           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NUP153 gene (3 alternative transcripts): 
    NM_001278209.1  NM_001278210.1  NM_005124.3  

    Unigene Cluster for NUP153:

    Nucleoporin 153kDa
    Hs.601591  [show with all ESTs]
    Unigene Representative Sequence: AB210024
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262077(uc003ncd.1 uc011dje.1 uc010jpl.1) ENST00000537253

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NUP153 (see all 54):
    hsa-miR-361-5p hsa-miR-429 hsa-miR-513a-5p hsa-miR-548k hsa-let-7a-2* hsa-miR-29b-1* hsa-miR-3167 hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidNUP153 3' UTR sequence
    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector: NUP153 (NM_005124)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUP153
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NUP153
      QuantiTect SYBR Green Assays in human, mouse, rat NUP153
      QuantiFast Probe-based Assays in human, mouse, rat NUP153

    Additional mRNA sequence: 

    AB210024.1 AK295644.1 BC052965.1 Z25535.1 

    15 DOTS entries:

    DT.446927  DT.434816  DT.102824068  DT.121337199  DT.441584  DT.95148921  DT.95276137  DT.100668485 
    DT.100783295  DT.121337101  DT.121337117  DT.121337129  DT.95276139  DT.99971020  DT.97823514 

    Selected AceView cDNA sequences (see all 284):

    AA682410 AW168038 AI654609 AI636641 AI280382 BQ003194 BF514609 T28358 
    AI334024 AW243855 BE302064 AA465205 AA287055 AL043770 BQ000141 AW341977 
    AI263520 AA401272 BE676763 CA419219 AI654426 T09409 AI246397 AL043523 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NUP153 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 22a · 22b ^ 23a · 23b ^ 24
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for NUP153

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    NUP153 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCCTTAGAA
    NUP153 Expression
    About this image


    NUP153 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    NUP153 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NUP153 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.601591
        Custom PCR Arrays for NUP153
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NUP153 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nup1531 , 5 nucleoporin 1531, 5 85.66(n)1
    83.12(a)1
      13 (24.30 cM)5
    2182101  NM_175749.21  NP_786925.21 
     466799055 
    chicken
    (Gallus gallus)
    Aves NUP1531 nucleoporin 153kDa 69.25(n)
    65.02(a)
      420848  XM_418937.4  XP_418937.4 
    lizard
    (Anolis carolinensis)
    Reptilia NUP1536
    nucleoporin 153kDa
    56(a)
    1 ↔ 1
    4(59114621-59142860)
    African clawed frog
    (Xenopus laevis)
    Amphibia NUP1532 nucleoporin Nup153 76.36(n)    AF434196.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd23d092 Transcribed sequence with weak similarity to protein more 88.52(n)    57057051 
    fruit fly
    (Drosophila melanogaster)
    Insecta Nup1536
    Nucleoporin 153
    14(a)
    1 ↔ 1
    X(16493356-16504492)


    ENSEMBL Gene Tree for NUP153 (if available)
    TreeFam Gene Tree for NUP153 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NUP153 gene
    1 SIMAP similar gene for NUP153 using alignment to 3 protein entries:     NU153_HUMAN (see all proteins):
    NUP153 variant protein

    Find genes that share paralogs with NUP153           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NUP153 (see all 2213)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs715367431,2
    C--17593605(+) AAAAA-/AAAA  
      
    /AAAAA
    GTACT
    1 -- int11NA 2
    rs676847051,2
    C--17612986(+) TTTTT-/T/TT  
            
    GAGAT
    1 -- int11NA 2
    rs2015258201,2
    --17614868(+) ACTGG-/GCGGGGG 1 -- ds50010--------
    rs93710051,2
    C,A--17614870(+) CTGGGG/CGGGGG 1 -- ds50014Minor allele frequency- C:0.48NA CSA WA 241
    rs93500501,2
    --17614873(+) gggggG/Tggggg 1 -- ds50010--------
    rs1853374321,2
    --17614882(+) GGGAGG/TGCAGT 1 -- ds50010--------
    rs93500511,2
    C,F,A,H--17614952(+) CAAGAC/ACTTTA 1 -- ds500123Minor allele frequency- A:0.45NA NS EA WA CSA 2474
    rs787846241,2
    C,F--17615041(+) AAGGTA/GCCTAA 1 -- ds50011Minor allele frequency- G:0.04WA 118
    rs1463591811,2
    --17615208(+) TATTTC/TACAAA 1 -- ds50010--------
    rs1396592361,2
    C--17615803(+) TCAGGA/CTTCCT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NUP153 (17615269 - 17706818 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for NUP153:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv268526CNV Insertion20981092
    nsv883456CNV Gain21882294
    nsv883457CNV Gain21882294
    nsv830596CNV Gain17160897
    nsv883458CNV Gain21882294
    nsv516012CNV Gain+Loss19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603948    OMIM disorders: --


    Find genes that share disorders with NUP153           About GenesLikeMe

    1 Novoseek inferred disease relationship for NUP153 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 1.21 1 19369352 (1)

    Genetic Association Database (GAD): NUP153
    Human Genome Epidemiology (HuGE) Navigator: NUP153 (2 documents)

    Export disorders for NUP153 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NUP153 gene, integrated from 10 sources (see all 137):
    (articles sorted by number of sources associating them with NUP153)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence analysis of a cDNA encoding a human nuclear pore complex protein, hnup153. (PubMed id 8110839)1, 2, 3, 9 McMorrow I.... Burke B. (Biochim. Biophys. Acta 1994)
    2. Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket. (PubMed id 15229283)1, 2, 9 Krull S.... Cordes V.C. (Mol. Biol. Cell 2004)
    3. Integrase interacts with nucleoporin NUP153 to mediate the nuclear import of human immunodeficiency virus type 1. (PubMed id 19369352)1, 2, 9 Woodward C.L.... Chow S.A. (J. Virol. 2009)
    4. Nucleoporin 153 arrests the nuclear import of hepatitis B virus capsids in the nuclear basket. (PubMed id 20126445)1, 2 Schmitz A.... Kann M. (PLoS Pathog. 2010)
    5. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
    6. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    8. Direct interaction with nup153 mediates binding of Tpr to the periphery of the nuclear pore complex. (PubMed id 12802065)1, 2 Hase M.E. and Cordes V.C. (Mol. Biol. Cell 2003)
    9. Tpr is localized within the nuclear basket of the pore complex and has a role in nuclear protein export. (PubMed id 11839768)1, 2 Frosst P.... Gerace L. (J. Cell Biol. 2002)
    10. Exportin-5, a novel karyopherin, mediates nuclear export of double- stranded RNA binding proteins. (PubMed id 11777942)1, 2 Brownawell A.M. and Macara I.G. (J. Cell Biol. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9972 HGNC: 8062 AceView: NUP153 Ensembl:ENSG00000124789 euGenes: HUgn9972
    ECgene: NUP153 Kegg: 9972 H-InvDB: NUP153

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NUP153 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NUP153 gene:
    Search GeneIP for patents involving NUP153

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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