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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NUP133 Gene

protein-coding GIFtS: 59
GCID: GC01M229580

nucleoporin 133kDa

(Previous name: nucleoporin 133kD )

Explore 1 disease affiliated with
NUP133 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Nucleoporin 133kDa¹ ²		Nucleoporin 133kD¹
Nucleoporin Nup133² ³		HNUP133¹
133 KDa Nucleoporin² ³		Nuclear Pore Complex Protein Nup133²
FLJ10814¹

External Ids:	HGNC: 18016¹	Entrez Gene: 55746²	Ensembl: ENSG00000069248⁷	OMIM: 607613⁵	UniProtKB: Q8WUM0³

Export aliases for NUP133 gene to outside databases

Previous GC identifers: GC01M228024 GC01M225271 GC01M225976 GC01M226538 GC01M225883 GC01M227643 GC01M200067

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NUP133:

The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two

concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the

flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different

polypeptide subunits, many of which belong to the nucleoporin family. The nucleoporin protein encoded by this gene

displays evolutionarily conserved interactions with other nucleoporins. This protein, which localizes to both sides of

the nuclear pore complex at interphase, remains associated with the complex during mitosis and is targeted at early

stages to the reforming nuclear envelope. This protein also localizes to kinetochores of mitotic cells. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NU133_HUMAN, Q8WUM0

Function: Involved in poly(A)+ RNA transport

Gene Wiki entry for NUP133

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_167186.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NUP133 gene promoter:
C/EBPbeta AML1a SREBP-1c SREBP-1b SREBP-1a POU2F1 POU2F1a TGIF Ik-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NUP133 promoter sequence

Search SABiosciences Chromatin IP Primers for NUP133

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUP133

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.13 Ensembl cytogenetic band: 1q42.13 HGNC cytogenetic band: 1q42.13

NUP133 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUP133 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M229580: view genomic region (about GC identifiers)

Start:	229,577,044 bp from pter	End:	229,644,103 bp from pter
Size:	67,060 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NU133_HUMAN, Q8WUM0 (See protein sequence)

Recommended Name: Nuclear pore complex protein Nup133

Size: 1156 amino acids; 128979 Da

Subunit: Forms part of the Nup160 subcomplex in the nuclear pore which is composed of Nup160, Nup133, Nup107 and Nup96.

This complex plays a role in RNA export and in tethering Nup98 and Nup153 to the nucleus

Subcellular location: Nucleus, nuclear pore complex. Chromosome, centromere, kinetochore. Note=Located on both the

cytoplasmic and nuclear sides of the nuclear pore. During mitosis, localizes to the kinetochores

Sequence caution: Sequence=BAA91885.1; Type=Erroneous initiation; Sequence=BAB14106.1; Type=Erroneous initiation;

4 PDB 3D structures from and Proteopedia for NUP133:

1XKS (3D)

3CQC (3D)

3CQG (3D)

3I4R (3D)

Secondary accessions: B2RAZ8 Q5T8N0 Q9H9W2 Q9NV71 Q9NVC4

Explore the universe of human proteins at neXtProt for NUP133: NX_Q8WUM0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8WUM0

NUP133 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_060700.2

ENSEMBL proteins:

ENSP00000261396 ENSP00000355640 ENSP00000355639 ENSP00000443496

Reactome Protein details: Q8WUM0
Human Recombinant Protein Products:

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	Novus Biologicals NUP133 Protein Novus Biologicals NUP133 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NUP133

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000777	colocalizes with condensed chromosome kinetochore	IDA	17098863
GO:0000940	colocalizes with condensed chromosome outer kinetochore	IDA	17363900
GO:0005635	nuclear envelope	TAS	--
GO:0005643	nuclear pore	IDA	17098863
GO:0005829	cytosol	TAS	--

NUP133 for ontologies About GeneDecksing

NUP133 Antibody Products:

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Assay Products for NUP133:

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	Uscn ELISAs and CLIAs for NUP133

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NUP133 for domains About GeneDecksing

3 InterPro domains/families:

IPR014908 Nucleoporin_Nup133/Nup155_N

IPR015943 WD40/YVTN_repeat-like_dom

IPR007187 Nucleoporin_Nup133/Nup155_C

Graphical View of Domain Structure for InterPro Entry Q8WUM0

ProtoNet protein and cluster: Q8WUM0

1 Blocks protein family: IPB007187 Nup133 nucleoporin

UniProtKB/Swiss-Prot: NU133_HUMAN, Q8WUM0

Similarity: Belongs to the nucleoporin Nup133 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: NU133_HUMAN, Q8WUM0

Function: Involved in poly(A)+ RNA transport

miRNA Products:		OriGene 3'-UTR Clone: NUP133 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NUP133
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate NUP133:
		hsa-miR-301b hsa-miR-301a hsa-miR-3666 hsa-miR-454 hsa-miR-4295 hsa-miR-130a hsa-miR-3148 hsa-miR-130b

		SwitchGear 3'UTR luciferase reporter plasmid: NUP133 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NUP133 (see all 4) OriGene shRNA RFP: NUP133 OriGene siRNA: NUP133
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUP133

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for NUP133

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUP133 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUP133 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NUP133 (NM_018230)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUP133

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NUP133
		Search LifeMap BioReagents cell lines for NUP133

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUP133

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005487	nucleocytoplasmic transporter activity	IDA	11684705
GO:0005515	protein binding	IPI	11564755

NUP133 for ontologies About GeneDecksing

6 GenomeRNAi human phenotypes for NUP133:

Decreased Tat-dependent transc	Decreased p24 protein expressi	Decreased viability of wild-ty	G0/1 arrest
Increased G1 DNA content	Increased gamma-H2AX phosphory

Animal Models:
6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Nup133):

cardiovascular system	embryogenesis	growth/size	homeostasis/metabolism	mortality/aging
nervous system

NUP133 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus

8/11 pathways (see all 11)
Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus	1.00	Interactions of Vpr with host cellular proteins	0.70
Nuclear import of Rev protein	0.76	Glucose transport	0.57
Vpr-mediated nuclear import of PICs	0.76	Hexose transport	0.55
Regulation of Glucokinase by Glucokinase Regulatory Protein	0.75	ISG15 antiviral mechanism	0.49

M Phase

M Phase	1.00	Mitotic Anaphase	0.85
Mitotic M-M/G1 phases	0.88	Separation of Sister Chromatids	0.80
Mitotic Metaphase and Anaphase	0.85

Resolution of Sister Chromatid Cohesion

	Resolution of Sister Chromatid Cohesion	1.00			Mitotic Prometaphase	0.93
	Kinetochore assembly	0.96

Cytokine Signaling in Immune system

Cytokine Signaling in Immune system

1.00

Interferon Signaling

0.61

HIV Infection

HIV Infection

1.00

Host Interactions of HIV factors

0.64

Pathway sources
See GeneCards unified pathways
Show all pathways

5/33 Reactome Pathways for NUP133 (see all 33)

	Mitotic Prometaphase
	Interactions of Rev with host cellular proteins
	Rev-mediated nuclear export of HIV-1 RNA
	Interferon Signaling
	Vpr-mediated nuclear import of PICs

1 Kegg Pathway (Kegg details for NUP133):

RNA transport

NUP133 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NUP133

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/138 Interacting proteins for NUP133 (Q8WUM0^{1, 2, 3} ENSP00000261396⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 138)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NUP107	P57740¹^,²^,³, ENSP00000229179⁴	EBI-295695,EBI-295687 MINT-4788188 MINT-4788150 I2D: score=3 STRING: ENSP00000229179
AHCTF1	Q8WYP5²^,³, ENSP00000375705⁴	MINT-4301609 I2D: score=1 STRING: ENSP00000375705
CENPF	P49454²^,³, ENSP00000355922⁴	MINT-4788132 MINT-4788150 I2D: score=2 STRING: ENSP00000355922
NUP98	P52948³, ENSP00000316032⁴	I2D: score=4 STRING: ENSP00000316032
MYC	P01106³, ENSP00000367207⁴	I2D: score=3 STRING: ENSP00000367207

About this table

Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000087	M phase of mitotic cell cycle	TAS	--
GO:0000236	mitotic prometaphase	TAS	--
GO:0000278	mitotic cell cycle	TAS	--
GO:0005975	carbohydrate metabolic process	TAS	--
GO:0006406	mRNA export from nucleus	IDA	11684705

NUP133 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NUP133
Search CenterWatch for drugs/clinical trials and news about NUP133 / NU133

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NUP133 gene:

NM_018230.2

Unigene Cluster for NUP133:

Nucleoporin 133kDa

Hs.12457 [show with all ESTs]

Unigene Representative Sequence: AK001676

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000261396(uc001htn.3) ENST00000366679 ENST00000490352 ENST00000485119

ENST00000366678 ENST00000537506

miRNA Products:		OriGene 3'-UTR Clone: NUP133 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NUP133
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate NUP133:
		hsa-miR-301b hsa-miR-301a hsa-miR-3666 hsa-miR-454 hsa-miR-4295 hsa-miR-130a hsa-miR-3148 hsa-miR-130b

		SwitchGear 3'UTR luciferase reporter plasmid: NUP133 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NUP133 (see all 4) OriGene shRNA RFP: NUP133 OriGene siRNA: NUP133
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUP133

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUP133 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUP133 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NUP133 (NM_018230)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUP133
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUP133

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUP133
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUP133

Additional cDNA sequence:

AF052123.1 AK001676.1 AK001754.1 AK022572.1 AK092339.1 AK304061.1 AK304861.1 AK314431.1

BC020107.1

16 DOTS entries:

DT.95212793 DT.455814 DT.95212752 DT.70102365 DT.100784364 DT.75186573 DT.95212786 DT.95212787

DT.100774395 DT.121402674 DT.75127098 DT.86857397 DT.91718225 DT.91808639 DT.92449712 DT.91660243

24/303 AceView cDNA sequences (see all 303):

BX279556 AK022572 C01331 R19923 BG779519 BQ086193 CF135835 AA534880

AI914414 AU133448 CK903624 BP362868 CB306773 BF102972 CA426518 AI805453

BG150517 AI225068 AI086357 Z44088 BX494306 CR593569 AA788599 AL583194

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for NUP133 (see all 8) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17a	·	17b	^	18	^	19	^	20	^	21a	·	21b	·	21c	^
SP1:							-						-				-																								-				-
SP2:							-						-				-																								-				-
SP3:
SP4:																																													-
SP5:

ExUns:	22a	·	22b	^	23	^	24a	·	24b	^	25	^	26	^	27a	·	27b	^	28	^	29	^	30a	·	30b	·	30c
SP1:															-
SP2:			-		-		-								-
SP3:
SP4:
SP5:					-

ECgene alternative splicing isoforms for NUP133

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NUP133 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAGCTTGAT

About this image
See NUP133 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NUP133

SOURCE GeneReport for Unigene cluster: Hs.12457

SABiosciences Custom PCR Arrays for NUP133

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUP133 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUP133
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUP133

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUP133

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUP133 gene from 9/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Nup133^{1 , 5}	nucleoporin 133^{1, 5}	80.38(n)¹ 83.29(a)¹		8 (72.27 cM)⁵ 234865¹ NM_172288.2¹ NP_758492.2¹ 123897123⁵
chicken (Gallus gallus)	Aves	NUP133¹	nucleoporin 133kDa	74.32(n) 73.74(a)		421535 XM_419576.3 XP_419576.3
lizard (Anolis carolinensis)	Reptilia	NUP133⁶	--	66(a)	1 ↔ 1	1(222223311-222265816)
African clawed frog (Xenopus laevis)	Amphibia	Xl.9485²	Xenopus laevis transcribed sequence with weak similarity to protein refNP_060700.1 (H.sapiens) hypothetical protein FLJ10814; nucleoporin 133 [Homo sapiens] less	72.8(n)		BX842923.1
zebrafish (Danio rerio)	Actinopterygii	wufa04e09²	Danio rerio cDNA clone MGC55311 IMAGE2600558, complete cds less	72.23(n)		BC052764.1
fruit fly (Drosophila melanogaster)	Insecta	CG6958³ Nup133¹	Nucleoporin 133¹	26(a)³ 41.39(n)¹ 28.48(a)¹		94C1³ 42680¹ NM_142823.2¹ NP_651080.2¹
worm (Caenorhabditis elegans)	Secernentea	npp-15⁶	Nuclear pore complex protein 15	17(a)	1 ↔ 1	III(7928984-7932929)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G05120⁶	nucleoporin, Nup133/Nup155-like protein	15(a)	1 ↔ 1	2(1841887-1846912)
rice (Oryza sativa)	Liliopsida	--	nucleoporin, putative, expressed	16(a)	1 ↔ 1	3(6572198-6579719)

ENSEMBL Gene Tree for NUP133 (if available)
TreeFam Gene Tree for NUP133 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs73112268^1,2	C,	--	200067566(+)	`GATGCT/CGGGCT`	1	--	ds500¹		2		WA	120
rs80145187^1,2	C,	--	200067697(+)	`TCCAAC/ACTCTG`	1	--	ds500¹		1		NA	2
rs75443114^1,2	C,	--	200068191(+)	`CCCTAG/AATTCT`	1	--	ut3¹		2		CSA WA	120
rs11809977^1,2	C,F,H,	--	200068841(+)	`TATAAC/TGTCAC`	1	--	int¹		11		NS EA NA WA	1182
rs200239103^1,2	C	--	200069411(+)	`TGGTTC/TTTTTT`	1	--	int¹		0	--	--	--	--
rs79508250^1,2	C,F,	--	200070245(+)	`NNNNAT/CGAAAT`	1	--	int¹		1		NA	120
rs73112270^1,2	C,	--	200070311(+)	`TATTGT/GACATG`	1	--	int¹		2		WA	120
rs78723398^1,2	F,	--	200070374(+)	`CGCACG/ACCTTA`	1	--	int¹		1		WA	118
rs112293528^1,2	C	--	200070616(+)	`TTTTTT/AAAATA`	1	--	int¹		2		WA CSA	3
rs61824298^1,2	C,F,	--	200071542(+)	`GTAACA/GTATTC`	1	--	int¹		3		NA	124

HapMap Linkage Disequilibrium report for NUP133 (229577044 - 229644103 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NUP133: --
Locus Specific Mutation Databases (LSDB): NUP133

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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NUP133 for disorders           About GeneDecksing

OMIM gene information: 607613    OMIM disorders: --

1 disease for NUP133:    About MalaCards

hepatitis

Human Genome Epidemiology (HuGE) Navigator: NUP133 (4 documents)

Export disorders for NUP133 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for NUP133 gene, integrated from 9 sources (see all 48):
(articles sorted by number of sources associating them with NUP133)

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Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export. (PubMed id 11684705)^{1, 2, 3, 9} Vasu S.... Forbes D.J. (2001)
An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells. (PubMed id 11564755)^{1, 2, 9} Belgareh N.... Doye V. (2001)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Structural and functional analysis of Nup133 domains reveals modular building blocks of the nuclear pore complex. (PubMed id 15557116)^{1, 2} Berke I.C.... Schwartz T.U. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Structural and functional studies of Nup107/Nup133 interaction and its implications for the architecture of the nuclear pore complex. (PubMed id 18570875)^{1, 9} Boehmer T....Schwartz T.U. (2008)
Architectural nucleoporins Nup157/170 and Nup133 are structurally related and descend from a second ancestral element. (PubMed id 19674973)^{1, 9} Whittle J.R. and Schwartz T.U. (2009)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 55746	HGNC: 18016	AceView: NUP133	Ensembl:ENSG00000069248	euGenes: HUgn55746
ECgene: NUP133	Kegg: 55746	H-InvDB: NUP133

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NUP133	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NUP133 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NUP133 gene:
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nucleoporin 133kDa

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nucleoporin 133kDa

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