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Aliases for NUP133 Gene

Aliases for NUP133 Gene

  • Nucleoporin 133kDa 2 3 5
  • 133 KDa Nucleoporin 3 4
  • Nucleoporin Nup133 3 4
  • Nucleoporin 133kD 2 3
  • HNUP133 3

External Ids for NUP133 Gene

Previous GeneCards Identifiers for NUP133 Gene

  • GC01M228024
  • GC01M225271
  • GC01M225976
  • GC01M226538
  • GC01M225883
  • GC01M227643
  • GC01M229580
  • GC01M200067

Summaries for NUP133 Gene

Entrez Gene Summary for NUP133 Gene

  • The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. The nucleoporin protein encoded by this gene displays evolutionarily conserved interactions with other nucleoporins. This protein, which localizes to both sides of the nuclear pore complex at interphase, remains associated with the complex during mitosis and is targeted at early stages to the reforming nuclear envelope. This protein also localizes to kinetochores of mitotic cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for NUP133 Gene

NUP133 (Nucleoporin 133kDa) is a Protein Coding gene. Among its related pathways are Mitotic Metaphase and Anaphase and Cellular response to heat stress. GO annotations related to this gene include nucleocytoplasmic transporter activity.

UniProtKB/Swiss-Prot for NUP133 Gene

  • Involved in poly(A)+ RNA transport.

Gene Wiki entry for NUP133 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP133 Gene

Genomics for NUP133 Gene

Regulatory Elements for NUP133 Gene

Enhancers for NUP133 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NUP133 on UCSC Golden Path with GeneCards custom track

Promoters for NUP133 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NUP133 on UCSC Golden Path with GeneCards custom track

Genomic Location for NUP133 Gene

229,440,260 bp from pter
229,508,341 bp from pter
68,082 bases
Minus strand

Genomic View for NUP133 Gene

Genes around NUP133 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUP133 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUP133 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP133 Gene

Proteins for NUP133 Gene

  • Protein details for NUP133 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nuclear pore complex protein Nup133
    Protein Accession:
    Secondary Accessions:
    • B2RAZ8
    • Q5T8N0
    • Q9H9W2
    • Q9NV71
    • Q9NVC4

    Protein attributes for NUP133 Gene

    1156 amino acids
    Molecular mass:
    128979 Da
    Quaternary structure:
    • Forms part of the Nup160 subcomplex in the nuclear pore which is composed of NUP160, NUP133, NUP107 and Nup96. This complex plays a role in RNA export and in tethering Nup98 and NUP153 to the nucleus.
    • Sequence=BAA91885.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14106.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NUP133 Gene

neXtProt entry for NUP133 Gene

Proteomics data for NUP133 Gene at MOPED

Post-translational modifications for NUP133 Gene

  • Ubiquitination at Lys 523, Lys 674, Lys 787, Lys 842, and Lys 1110
  • Modification sites at PhosphoSitePlus

Other Protein References for NUP133 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NUP133 Gene

Domains & Families for NUP133 Gene

Gene Families for NUP133 Gene

Protein Domains for NUP133 Gene

Suggested Antigen Peptide Sequences for NUP133 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the nucleoporin Nup133 family.
  • Belongs to the nucleoporin Nup133 family.
genes like me logo Genes that share domains with NUP133: view

Function for NUP133 Gene

Molecular function for NUP133 Gene

UniProtKB/Swiss-Prot Function:
Involved in poly(A)+ RNA transport.
genes like me logo Genes that share phenotypes with NUP133: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUP133 Gene

Localization for NUP133 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP133 Gene

Nucleus, nuclear pore complex. Chromosome, centromere, kinetochore. Note=Located on both the cytoplasmic and nuclear sides of the nuclear pore (PubMed:11564755). During mitosis, localizes to the kinetochores (PubMed:11564755). {ECO:0000269 PubMed:11564755, ECO:0000269 PubMed:11684705}.

Subcellular locations from

Jensen Localization Image for NUP133 Gene COMPARTMENTS Subcellular localization image for NUP133 gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 2

No data available for Gene Ontology (GO) - Cellular Components for NUP133 Gene

Pathways & Interactions for NUP133 Gene

SuperPathways for NUP133 Gene

Superpath Contained pathways
1 Regulation of Glucokinase by Glucokinase Regulatory Protein
2 Infectious disease
3 Cell Cycle, Mitotic
4 Mitotic Prophase
5 Influenza Viral RNA Transcription and Replication
genes like me logo Genes that share pathways with NUP133: view

Pathways by source for NUP133 Gene

Gene Ontology (GO) - Biological Process for NUP133 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006406 mRNA export from nucleus IDA,TAS --
GO:0006409 tRNA export from nucleus TAS --
GO:0006606 protein import into nucleus IBA --
GO:0006999 nuclear pore organization IMP 15146057
genes like me logo Genes that share ontologies with NUP133: view

No data available for SIGNOR curated interactions for NUP133 Gene

Drugs & Compounds for NUP133 Gene

No Compound Related Data Available

Transcripts for NUP133 Gene

Unigene Clusters for NUP133 Gene

Nucleoporin 133kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUP133 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21a · 21b · 21c ^
SP1: - - - - -
SP2: - - - - -
SP4: -
SP7: -

ExUns: 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30a · 30b · 30c
SP1: -
SP2: - - - -
SP5: -

Relevant External Links for NUP133 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NUP133 Gene

mRNA expression in normal human tissues for NUP133 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NUP133 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.6) and Lymph node (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUP133 Gene

SOURCE GeneReport for Unigene cluster for NUP133 Gene Hs.12457

genes like me logo Genes that share expression patterns with NUP133: view

Protein tissue co-expression partners for NUP133 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NUP133 Gene

Orthologs for NUP133 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUP133 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NUP133 35
  • 89.07 (n)
  • 90.05 (a)
NUP133 36
  • 90 (a)
(Canis familiaris)
Mammalia NUP133 35
  • 90.43 (n)
  • 91.09 (a)
NUP133 36
  • 91 (a)
(Mus musculus)
Mammalia Nup133 35
  • 80.38 (n)
  • 83.29 (a)
Nup133 16
Nup133 36
  • 83 (a)
(Pan troglodytes)
Mammalia NUP133 35
  • 99.48 (n)
  • 99.31 (a)
NUP133 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Nup133 35
  • 78.48 (n)
  • 80.37 (a)
(Monodelphis domestica)
Mammalia NUP133 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia NUP133 36
  • 71 (a)
(Gallus gallus)
Aves NUP133 35
  • 74.32 (n)
  • 73.74 (a)
NUP133 36
  • 72 (a)
(Anolis carolinensis)
Reptilia NUP133 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nup133 35
  • 66.02 (n)
  • 66.02 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9485 35
(Danio rerio)
Actinopterygii nup133 35
  • 60.82 (n)
  • 59.52 (a)
wufa04e09 35
nup133 36
  • 59 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12743 35
fruit fly
(Drosophila melanogaster)
Insecta CG6958 37
  • 26 (a)
Nup133 35
  • 42.05 (n)
  • 29.4 (a)
Nup133 36
  • 26 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003503 35
  • 42.21 (n)
  • 30.54 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1223 36
  • 32 (a)
Species with no ortholog for NUP133:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUP133 Gene

Gene Tree for NUP133 (if available)
Gene Tree for NUP133 (if available)

Paralogs for NUP133 Gene

No data available for Paralogs for NUP133 Gene

Variants for NUP133 Gene

Sequence variations from dbSNP and Humsavar for NUP133 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs428231 - 229,502,088(-) AGCTG(A/C)CCATT reference, missense
rs11805194 - 229,495,987(+) ACTGA(C/T)GTTTG reference, missense
rs1065674 - 229,487,591(-) GTGTC(A/G)GTTGA reference, missense
VAR_035854 A breast cancer sample
VAR_035855 A breast cancer sample

Structural Variations from Database of Genomic Variants (DGV) for NUP133 Gene

Variant ID Type Subtype PubMed ID
esv259426 OTHER Complex 20981092
esv259749 OTHER Complex 20981092

Variation tolerance for NUP133 Gene

Residual Variation Intolerance Score: 26.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.98; 89.96% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NUP133 Gene

Disorders for NUP133 Gene

Relevant External Links for NUP133

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NUP133 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUP133 Gene

Publications for NUP133 Gene

  1. Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export. (PMID: 11684705) Vasu S. … Forbes D.J. (J. Cell Biol. 2001) 2 3 4 23 67
  2. Architectural nucleoporins Nup157/170 and Nup133 are structurally related and descend from a second ancestral element. (PMID: 19674973) Whittle J.R. … Schwartz T.U. (J. Biol. Chem. 2009) 3 23
  3. Structural and functional studies of Nup107/Nup133 interaction and its implications for the architecture of the nuclear pore complex. (PMID: 18570875) Boehmer T. … Schwartz T.U. (Mol. Cell 2008) 3 23
  4. An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells. (PMID: 11564755) Belgareh N. … Doye V. (J. Cell Biol. 2001) 3 23
  5. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3

Products for NUP133 Gene

Sources for NUP133 Gene