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NUP133 Gene

protein-coding   GIFtS: 63
GCID: GC01M229580

Nucleoporin 133kDa

(Previous name: nucleoporin 133kD)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nucleoporin 133kDa1 2
Nucleoporin Nup1332 3
133 KDa Nucleoporin2 3
Nucleoporin 133kD1
hNUP1332
Nuclear Pore Complex Protein Nup1332

External Ids:    HGNC: 180161   Entrez Gene: 557462   Ensembl: ENSG000000692487   OMIM: 6076135   UniProtKB: Q8WUM03   

Export aliases for NUP133 gene to outside databases

Previous GC identifers: GC01M228024 GC01M225271 GC01M225976 GC01M226538 GC01M225883 GC01M227643 GC01M200067


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NUP133 Gene:
The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two
concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate
the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100
different polypeptide subunits, many of which belong to the nucleoporin family. The nucleoporin protein encoded
by this gene displays evolutionarily conserved interactions with other nucleoporins. This protein, which
localizes to both sides of the nuclear pore complex at interphase, remains associated with the complex during
mitosis and is targeted at early stages to the reforming nuclear envelope. This protein also localizes to
kinetochores of mitotic cells. (provided by RefSeq, Jul 2008)

GeneCards Summary for NUP133 Gene:
NUP133 (nucleoporin 133kDa) is a protein-coding gene. Diseases associated with NUP133 include breast and colorectal cancer, and influenza. GO annotations related to this gene include nucleocytoplasmic transporter activity.

UniProtKB/Swiss-Prot: NU133_HUMAN, Q8WUM0
Function: Involved in poly(A)+ RNA transport

Gene Wiki entry for NUP133 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_167186.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NUP133 gene promoter:
         C/EBPbeta   AML1a   SREBP-1c   SREBP-1b   SREBP-1a   POU2F1   POU2F1a   TGIF   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNUP133 promoter sequence
   Search Chromatin IP Primers for NUP133

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NUP133


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.13   Ensembl cytogenetic band:  1q42.13   HGNC cytogenetic band: 1q42.13

NUP133 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUP133 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M229580:  view genomic region     (about GC identifiers)

Start:
229,577,044 bp from pter      End:
229,644,103 bp from pter
Size:
67,060 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NU133_HUMAN, Q8WUM0 (See protein sequence)
Recommended Name: Nuclear pore complex protein Nup133  
Size: 1156 amino acids; 128979 Da
Subunit: Forms part of the Nup160 subcomplex in the nuclear pore which is composed of NUP160, NUP133, NUP107 and
Nup96. This complex plays a role in RNA export and in tethering Nup98 and NUP153 to the nucleus
Sequence caution: Sequence=BAA91885.1; Type=Erroneous initiation; Sequence=BAB14106.1; Type=Erroneous initiation;
4 PDB 3D structures from and Proteopedia for NUP133:
1XKS (3D)        3CQC (3D)        3CQG (3D)        3I4R (3D)    
Secondary accessions: B2RAZ8 Q5T8N0 Q9H9W2 Q9NV71 Q9NVC4

Explore the universe of human proteins at neXtProt for NUP133: NX_Q8WUM0

Explore proteomics data for NUP133 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys35, Lys523, Lys674, Lys787, Lys842, Lys1110
  • Modification sites at PhosphoSitePlus

  • See NUP133 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060700.2  
    ENSEMBL proteins: 
     ENSP00000261396   ENSP00000355639   ENSP00000443496  
    Reactome Protein details: Q8WUM0

    NUP133 Human Recombinant Protein Products:

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    Novus Biologicals NUP133 Protein
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    NUP133 Assay Products:

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    Cloud-Clone Corp. CLIAs for NUP133


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR014908 Nucleoporin_Nup133/Nup155_N
     IPR015943 WD40/YVTN_repeat-like_dom
     IPR007187 Nucleoporin_Nup133/Nup155_C

    Graphical View of Domain Structure for InterPro Entry Q8WUM0

    ProtoNet protein and cluster: Q8WUM0

    1 Blocks protein domain: IPB007187 Nup133 nucleoporin

    UniProtKB/Swiss-Prot: NU133_HUMAN, Q8WUM0
    Similarity: Belongs to the nucleoporin Nup133 family


    NUP133 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NU133_HUMAN, Q8WUM0
    Function: Involved in poly(A)+ RNA transport

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005487nucleocytoplasmic transporter activity IDA11684705
    GO:0005515protein binding IPI11564755
         
    NUP133 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for NUP133:
     Decreased Tat-dependent transc  Decreased p24 protein expressi  Decreased viability of wild-ty  G0/1 arrest 
     Increased G1 DNA content  Increased gamma-H2AX phosphory 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nup133):
     cardiovascular system  embryogenesis  growth/size/body  homeostasis/metabolism  mortality/aging 
     nervous system 

    NUP133 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NUP133
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NUP133
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NUP133

    miRNA
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    miRTarBase miRNAs that target NUP133:
    hsa-mir-1301-3p (MIRT035996)

    Block miRNA regulation of human, mouse, rat NUP133 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate NUP133:
    hsa-miR-301b hsa-miR-301a hsa-miR-3666 hsa-miR-454 hsa-miR-4295 hsa-miR-130a hsa-miR-3148 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidNUP133 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NUP133

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: NUP133 (NM_018230)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUP133
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUP133

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUP133


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NU133_HUMAN, Q8WUM0: Nucleus, nuclear pore complex. Chromosome, centromere, kinetochore. Note=Located on both the
    cytoplasmic and nuclear sides of the nuclear pore. During mitosis, localizes to the kinetochores
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    mitochondrion2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000777colocalizes with condensed chromosome kinetochore IDA17098863
    GO:0000940colocalizes with condensed chromosome outer kinetochore IDA17363900
    GO:0005635nuclear envelope TAS--
    GO:0005643nuclear pore IDA11564755
    GO:0005829cytosol TAS--

    NUP133 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NUP133 About   (see all 16)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Regulation of Glucokinase by Glucokinase Regulatory Protein
    Transport of the SLBP Dependant Mature mRNA0.92
    Export of Viral Ribonucleoproteins from Nucleus0.88
    Transport of Mature mRNAs Derived from Intronless Transcripts0.92
    Transport of Ribonucleoproteins into the Host Nucleus0.88
    Transport of the SLBP independent Mature mRNA0.91
    Regulation of Glucokinase by Glucokinase Regulatory Protein0.87
    Nuclear import of Rev protein0.91
    Glucose transport0.87
    2HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    Host Interactions of HIV factors0.60
    3Interferon Signaling
    Interferon Signaling0.59
    ISG15 antiviral mechanism0.42
    Cytokine Signaling in Immune system0.59
    Antiviral mechanism by IFN-stimulated genes0.42
    4Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    5Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected Reactome Pathways for NUP133 (see all 9)
        Rev-mediated nuclear export of HIV RNA
    Regulation of Glucokinase by Glucokinase Regulatory Protein
    Nuclear Pore Complex (NPC) Disassembly
    Nuclear import of Rev protein
    Resolution of Sister Chromatid Cohesion


    1 Kegg Pathway  (Kegg details for NUP133):
        RNA transport


    NUP133 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NUP133
    Interactions:

        GeneGlobe Interaction Network for NUP133

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NUP133 (Q8WUM01, 2, 3 ENSP000002613964) via UniProtKB, MINT, STRING, and/or I2D (see all 209)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NUP107P577401, 2, 3, ENSP000002291794EBI-295695,EBI-295687 MINT-4788188 MINT-4788150 I2D: score=3 STRING: ENSP00000229179
    CENPFP494541, 2, 3, ENSP000003559224EBI-295695,EBI-968343 MINT-4788132 MINT-4788150 I2D: score=2 STRING: ENSP00000355922
    AHCTF1Q8WYP52, 3, ENSP000003757054MINT-4301609 I2D: score=1 STRING: ENSP00000375705
    MYCP011063, ENSP000003672074I2D: score=3 STRING: ENSP00000367207
    NUP37Q8NFH43, ENSP000002510744I2D: score=1 STRING: ENSP00000251074
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006406mRNA export from nucleus IDA11684705
    GO:0006999nuclear pore organization IMP15146057
    GO:0007077mitotic nuclear envelope disassembly TAS--

    NUP133 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NUP133 (NU133)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NUP133 gene: 
    NM_018230.2  

    Unigene Cluster for NUP133:

    Nucleoporin 133kDa
    Hs.12457  [show with all ESTs]
    Unigene Representative Sequence: AK001676
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261396(uc001htn.3) ENST00000490352 ENST00000485119 ENST00000366678
    ENST00000537506
    miRNA
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    Block miRNA regulation of human, mouse, rat NUP133 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate NUP133:
    hsa-miR-301b hsa-miR-301a hsa-miR-3666 hsa-miR-454 hsa-miR-4295 hsa-miR-130a hsa-miR-3148 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidNUP133 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for NUP133
    Predesigned siRNA for gene silencing in human, mouse, rat NUP133
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NUP133 (NM_018230)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUP133
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUP133
    Primer
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    OriGene qPCR primer pairs and template standards for NUP133
    OriGene qSTAR qPCR primer pairs in human, mouse for NUP133
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NUP133
      QuantiTect SYBR Green Assays in human, mouse, rat NUP133
      QuantiFast Probe-based Assays in human, mouse, rat NUP133

    Additional mRNA sequence: 

    AF052123.1 AK001676.1 AK001754.1 AK022572.1 AK092339.1 AK304061.1 AK304861.1 AK314431.1 
    BC020107.1 

    16 DOTS entries:

    DT.95212793  DT.455814  DT.95212752  DT.70102365  DT.100784364  DT.75186573  DT.95212786  DT.95212787 
    DT.100774395  DT.121402674  DT.75127098  DT.86857397  DT.91718225  DT.91808639  DT.92449712  DT.91660243 

    Selected AceView cDNA sequences (see all 303):

    AA600911 BX279556 BI963027 CR593569 AI862306 R19923 AU142302 AA251982 
    AI859524 BU947948 AI276857 AI624125 CR617378 CA424910 BM715830 N41982 
    BU947683 AA810040 AF052123 AA970775 AI074632 AX747487 AA738469 BF102972 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NUP133 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21a · 21b · 21c ^
    SP1:                    -                 -           -                                                                       -           -                     
    SP2:                    -                 -           -                                                                       -           -                     
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                      -                     
    SP5:                                                                                                                                                            

    ExUns: 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30a · 30b · 30c
    SP1:                                            -                                       
    SP2:        -     -     -                       -                                       
    SP3:                                                                                    
    SP4:                                                                                    
    SP5:              -                                                                     


    ECgene alternative splicing isoforms for NUP133

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NUP133 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAGCTTGAT
    NUP133 Expression
    About this image


    NUP133 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
    NUP133 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NUP133 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.12457
        Custom PCR Arrays for NUP133
    Primer
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    OriGene qPCR primer pairs and template standards for NUP133
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    QuantiTect SYBR Green Assays in human, mouse, rat NUP133
    QuantiFast Probe-based Assays in human, mouse, rat NUP133
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUP133

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NUP133 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nup1331 , 5 nucleoporin 1331, 5 80.38(n)1
    83.29(a)1
      8 (72.27 cM)5
    2348651  NM_172288.21  NP_758492.21 
     1238971235 
    chicken
    (Gallus gallus)
    Aves NUP1331 nucleoporin 133kDa 74.32(n)
    73.74(a)
      421535  XM_419576.4  XP_419576.4 
    lizard
    (Anolis carolinensis)
    Reptilia NUP1336
    nucleoporin 133kDa
    67(a)
    1 ↔ 1
    1(222220581-222266251)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.94852 Xenopus laevis transcribed sequence with weak similarity more 72.8(n)    BX842923.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa04e092 Danio rerio cDNA clone MGC55311 IMAGE2600558, complete more 72.23(n)    BC052764.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG69583
    Nup1331
    Nucleoporin 1331 26(a)3
    42.05(n)1
    29.4(a)1
      94C13
    426801  NM_142823.31  NP_651080.21 


    ENSEMBL Gene Tree for NUP133 (if available)
    TreeFam Gene Tree for NUP133 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NUP133 (see all 1512)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358544
    A breast cancer sample4--see VAR_0358542 G V mis40--------
    VAR_0358554
    A breast cancer sample4--see VAR_0358552 G R mis40--------
    rs115873591,2
    H--200075553(+) ttttcC/Tttttt 1 -- int1 trp30--------
    rs38355741,2
    C--200093081(+) TTTTA-/TTT   
       
    /TTTA
    AGCGA
    2 -- int1 cds10--------
    rs339122871,2
    C--200096370(+) TCTCA-/A/AA  
            
    AAAAA
    1 -- int11NA 2
    rs675145881,2
    C--229580593(+) AAAAA-/A/AA  
            
    CCCAA
    1 -- int11NA 2
    rs584905381,2
    C--229584474(+) CTCTG-/GTAACA 1 -- int10--------
    rs114443771,2
    C--229594459(+) TTTTTT/-TTTTT 1 -- int1 trp31Minor allele frequency- -:0.00NA 2
    rs1135527381,2
    C--229616942(+) GAGGGT/-TACTG 1 -- int12Minor allele frequency- -:0.25CSA 4
    rs106661311,2
    C--229623410(+) TTTGT-/TTG   
      T
    /TTTG
    ATGAT
    1 -- int10--------

    HapMap Linkage Disequilibrium report for NUP133 (229577044 - 229644103 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NUP133:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv259749OTHER Complex20981092
    esv259426OTHER Complex20981092

    Locus Specific Mutation Databases (LSDB): NUP133

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NUP133
    DNA2.0 Custom Variant and Variant Library Synthesis for NUP133

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607613    OMIM disorders: --

    6 diseases for NUP133:    
    About MalaCards
    breast and colorectal cancer    influenza    hiv-1    colorectal cancer
    hepatitis    malaria


    NUP133 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NUP133
    Human Genome Epidemiology (HuGE) Navigator: NUP133 (4 documents)

    Export disorders for NUP133 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NUP133 gene, integrated from 10 sources (see all 58):
    (articles sorted by number of sources associating them with NUP133)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export. (PubMed id 11684705)1, 2, 3, 9 Vasu S.... Forbes D.J. (J. Cell Biol. 2001)
    2. An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells. (PubMed id 11564755)1, 2, 9 Belgareh N.... Doye V. (J. Cell Biol. 2001)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Structural and functional analysis of Nup133 domains reveals modular building blocks of the nuclear pore complex. (PubMed id 15557116)1, 2 Berke I.C.... Schwartz T.U. (J. Cell Biol. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Structural and functional studies of Nup107/Nup133 interaction and its implications for the architecture of the nuclear pore complex. (PubMed id 18570875)1, 9 Boehmer T....Schwartz T.U. (Mol. Cell 2008)
    10. Architectural nucleoporins Nup157/170 and Nup133 are structurally related and descend from a second ancestral element. (PubMed id 19674973)1, 9 Whittle J.R. and Schwartz T.U. (J. Biol. Chem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55746 HGNC: 18016 AceView: NUP133 Ensembl:ENSG00000069248 euGenes: HUgn55746
    ECgene: NUP133 Kegg: 55746 H-InvDB: NUP133

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NUP133 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NUP133 gene:
    Search GeneIP for patents involving NUP133

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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