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Aliases for NUP133 Gene

Aliases for NUP133 Gene

  • Nucleoporin 133 2 3 5
  • 133 KDa Nucleoporin 3 4
  • Nucleoporin 133kDa 2 3
  • Nucleoporin Nup133 3 4
  • Nuclear Pore Complex Protein Nup133 3
  • Nucleoporin 133kD 3
  • HNUP133 3

External Ids for NUP133 Gene

Previous GeneCards Identifiers for NUP133 Gene

  • GC01M228024
  • GC01M225271
  • GC01M225976
  • GC01M226538
  • GC01M225883
  • GC01M227643
  • GC01M229580
  • GC01M200067

Summaries for NUP133 Gene

Entrez Gene Summary for NUP133 Gene

  • The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. The nucleoporin protein encoded by this gene displays evolutionarily conserved interactions with other nucleoporins. This protein, which localizes to both sides of the nuclear pore complex at interphase, remains associated with the complex during mitosis and is targeted at early stages to the reforming nuclear envelope. This protein also localizes to kinetochores of mitotic cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for NUP133 Gene

NUP133 (Nucleoporin 133) is a Protein Coding gene. Among its related pathways are Transport of Mature Transcript to Cytoplasm and Regulation of Glucokinase by Glucokinase Regulatory Protein. GO annotations related to this gene include nucleocytoplasmic transporter activity.

UniProtKB/Swiss-Prot for NUP133 Gene

  • Involved in poly(A)+ RNA transport.

Gene Wiki entry for NUP133 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP133 Gene

Genomics for NUP133 Gene

Regulatory Elements for NUP133 Gene

Enhancers for NUP133 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around NUP133 on UCSC Golden Path with GeneCards custom track

Promoters for NUP133 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NUP133 on UCSC Golden Path with GeneCards custom track

Genomic Location for NUP133 Gene

Chromosome:
1
Start:
229,440,260 bp from pter
End:
229,508,341 bp from pter
Size:
68,082 bases
Orientation:
Minus strand

Genomic View for NUP133 Gene

Genes around NUP133 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUP133 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUP133 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP133 Gene

Proteins for NUP133 Gene

  • Protein details for NUP133 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUM0-NU133_HUMAN
    Recommended name:
    Nuclear pore complex protein Nup133
    Protein Accession:
    Q8WUM0
    Secondary Accessions:
    • B2RAZ8
    • Q5T8N0
    • Q9H9W2
    • Q9NV71
    • Q9NVC4

    Protein attributes for NUP133 Gene

    Size:
    1156 amino acids
    Molecular mass:
    128979 Da
    Quaternary structure:
    • Forms part of the Nup160 subcomplex in the nuclear pore which is composed of NUP160, NUP133, NUP107 and Nup96. This complex plays a role in RNA export and in tethering Nup98 and NUP153 to the nucleus.
    SequenceCaution:
    • Sequence=BAA91885.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14106.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NUP133 Gene

neXtProt entry for NUP133 Gene

Post-translational modifications for NUP133 Gene

  • Ubiquitination at Lys 523, Lys 674, Lys 787, Lys 842, and Lys 1110
  • Modification sites at PhosphoSitePlus

Other Protein References for NUP133 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NUP133 Gene

Domains & Families for NUP133 Gene

Gene Families for NUP133 Gene

Protein Domains for NUP133 Gene

Suggested Antigen Peptide Sequences for NUP133 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WUM0

UniProtKB/Swiss-Prot:

NU133_HUMAN :
  • Belongs to the nucleoporin Nup133 family.
Family:
  • Belongs to the nucleoporin Nup133 family.
genes like me logo Genes that share domains with NUP133: view

Function for NUP133 Gene

Molecular function for NUP133 Gene

UniProtKB/Swiss-Prot Function:
Involved in poly(A)+ RNA transport.

Gene Ontology (GO) - Molecular Function for NUP133 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005487 nucleocytoplasmic transporter activity IDA 11684705
GO:0005515 protein binding IPI 11564755
GO:0017056 structural constituent of nuclear pore IBA --
genes like me logo Genes that share ontologies with NUP133: view
genes like me logo Genes that share phenotypes with NUP133: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUP133 Gene

Localization for NUP133 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP133 Gene

Nucleus, nuclear pore complex. Chromosome, centromere, kinetochore. Note=Located on both the cytoplasmic and nuclear sides of the nuclear pore (PubMed:11564755). During mitosis, localizes to the kinetochores (PubMed:11564755). {ECO:0000269 PubMed:11564755, ECO:0000269 PubMed:11684705}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUP133 Gene COMPARTMENTS Subcellular localization image for NUP133 gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for NUP133 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000777 colocalizes_with condensed chromosome kinetochore IDA 17098863
GO:0000940 colocalizes_with condensed chromosome outer kinetochore IDA 17363900
GO:0005635 nuclear envelope TAS --
GO:0005643 nuclear pore IEA,IDA 11564755
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NUP133: view

Pathways & Interactions for NUP133 Gene

SuperPathways for NUP133 Gene

Superpath Contained pathways
1 Regulation of Glucokinase by Glucokinase Regulatory Protein
2 Infectious disease
.48
3 Cell Cycle, Mitotic
.61
4 Mitotic Prophase
5 Influenza Viral RNA Transcription and Replication
genes like me logo Genes that share pathways with NUP133: view

Pathways by source for NUP133 Gene

Gene Ontology (GO) - Biological Process for NUP133 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery IBA --
GO:0006325 chromatin organization IBA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0006406 mRNA export from nucleus TAS --
GO:0006409 tRNA export from nucleus TAS --
genes like me logo Genes that share ontologies with NUP133: view

No data available for SIGNOR curated interactions for NUP133 Gene

Drugs & Compounds for NUP133 Gene

No Compound Related Data Available

Transcripts for NUP133 Gene

mRNA/cDNA for NUP133 Gene

Unigene Clusters for NUP133 Gene

Nucleoporin 133kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUP133 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21a · 21b · 21c ^
SP1: - - - - -
SP2: - - - - -
SP3:
SP4: -
SP5:
SP6:
SP7: -
SP8:

ExUns: 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30a · 30b · 30c
SP1: -
SP2: - - - -
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:

Relevant External Links for NUP133 Gene

GeneLoc Exon Structure for
NUP133
ECgene alternative splicing isoforms for
NUP133

Expression for NUP133 Gene

mRNA expression in normal human tissues for NUP133 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NUP133 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.6) and Lymph node (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NUP133 Gene



Protein tissue co-expression partners for NUP133 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NUP133 Gene:

NUP133

SOURCE GeneReport for Unigene cluster for NUP133 Gene:

Hs.12457
genes like me logo Genes that share expression patterns with NUP133: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NUP133 Gene

Orthologs for NUP133 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUP133 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NUP133 34
  • 89.07 (n)
  • 90.05 (a)
NUP133 35
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUP133 34
  • 90.43 (n)
  • 91.09 (a)
NUP133 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nup133 34
  • 80.38 (n)
  • 83.29 (a)
Nup133 16
Nup133 35
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NUP133 34
  • 99.48 (n)
  • 99.31 (a)
NUP133 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nup133 34
  • 78.48 (n)
  • 80.37 (a)
oppossum
(Monodelphis domestica)
Mammalia NUP133 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUP133 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUP133 34
  • 74.32 (n)
  • 73.74 (a)
NUP133 35
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUP133 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nup133 34
  • 66.02 (n)
  • 66.02 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9485 34
zebrafish
(Danio rerio)
Actinopterygii nup133 34
  • 60.82 (n)
  • 59.52 (a)
wufa04e09 34
nup133 35
  • 59 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12743 34
fruit fly
(Drosophila melanogaster)
Insecta CG6958 36
  • 26 (a)
Nup133 34
  • 42.05 (n)
  • 29.4 (a)
Nup133 35
  • 26 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003503 34
  • 42.21 (n)
  • 30.54 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1223 35
  • 32 (a)
OneToOne
Species where no ortholog for NUP133 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUP133 Gene

ENSEMBL:
Gene Tree for NUP133 (if available)
TreeFam:
Gene Tree for NUP133 (if available)

Paralogs for NUP133 Gene

No data available for Paralogs for NUP133 Gene

Variants for NUP133 Gene

Sequence variations from dbSNP and Humsavar for NUP133 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs428231 - 229,502,088(-) AGCTG(A/C)CCATT reference, missense
rs11805194 - 229,495,987(+) ACTGA(C/T)GTTTG reference, missense
rs1065674 - 229,487,591(-) GTGTC(A/G)GTTGA reference, missense
VAR_035854 A breast cancer sample
VAR_035855 A breast cancer sample

Structural Variations from Database of Genomic Variants (DGV) for NUP133 Gene

Variant ID Type Subtype PubMed ID
dgv299e59 CNV tandem duplication 20981092
esv3379471 CNV duplication 20981092

Variation tolerance for NUP133 Gene

Residual Variation Intolerance Score: 26.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.98; 89.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUP133 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUP133

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUP133 Gene

Disorders for NUP133 Gene

Relevant External Links for NUP133

Genetic Association Database (GAD)
NUP133
Human Genome Epidemiology (HuGE) Navigator
NUP133
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUP133

No disorders were found for NUP133 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUP133 Gene

Publications for NUP133 Gene

  1. Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export. (PMID: 11684705) Vasu S. … Forbes D.J. (J. Cell Biol. 2001) 2 3 4 22 65
  2. An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells. (PMID: 11564755) Belgareh N. … Doye V. (J. Cell Biol. 2001) 3 4 22 65
  3. Biallelic Mutations in Nuclear Pore Complex Subunit NUP107 Cause Early-Childhood-Onset Steroid-Resistant Nephrotic Syndrome. (PMID: 26411495) Miyake N. … Matsumoto N. (Am. J. Hum. Genet. 2015) 3 4 65
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 65
  5. Architectural nucleoporins Nup157/170 and Nup133 are structurally related and descend from a second ancestral element. (PMID: 19674973) Whittle J.R. … Schwartz T.U. (J. Biol. Chem. 2009) 3 22 65

Products for NUP133 Gene

Sources for NUP133 Gene

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