Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NUP133 Gene

protein-coding   GIFtS: 59
GCID: GC01M229580

nucleoporin 133kDa

(Previous name: nucleoporin 133kD )
 Explore 1 disease affiliated with
NUP133 via our new
 Human Malady Compendium 
Biological research products
for NUP133
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Nucleoporin 133kDa1 2     Nucleoporin 133kD1
Nucleoporin Nup1332 3     HNUP1331
133 KDa Nucleoporin2 3     Nuclear Pore Complex Protein Nup1332
FLJ108141     

External Ids:    HGNC: 180161   Entrez Gene: 557462   Ensembl: ENSG000000692487   OMIM: 6076135   UniProtKB: Q8WUM03   

Export aliases for NUP133 gene to outside databases

Previous GC identifers: GC01M228024 GC01M225271 GC01M225976 GC01M226538 GC01M225883 GC01M227643 GC01M200067


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NUP133:
The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two
concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the
flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different
polypeptide subunits, many of which belong to the nucleoporin family. The nucleoporin protein encoded by this gene
displays evolutionarily conserved interactions with other nucleoporins. This protein, which localizes to both sides of
the nuclear pore complex at interphase, remains associated with the complex during mitosis and is targeted at early
stages to the reforming nuclear envelope. This protein also localizes to kinetochores of mitotic cells. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NU133_HUMAN, Q8WUM0
Function: Involved in poly(A)+ RNA transport

Gene Wiki entry for NUP133


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NUP133 gene promoter:
         C/EBPbeta   AML1a   SREBP-1c   SREBP-1b   SREBP-1a   POU2F1   POU2F1a   TGIF   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNUP133 promoter sequence
   Search SABiosciences Chromatin IP Primers for NUP133

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUP133


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.13   Ensembl cytogenetic band:  1q42.13   HGNC cytogenetic band: 1q42.13

NUP133 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUP133 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M229580:  view genomic region     (about GC identifiers)

Start:
229,577,044 bp from pter      End:
229,644,103 bp from pter
Size:
67,060 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NU133_HUMAN, Q8WUM0 (See protein sequence)
Recommended Name: Nuclear pore complex protein Nup133  
Size: 1156 amino acids; 128979 Da
Subunit: Forms part of the Nup160 subcomplex in the nuclear pore which is composed of Nup160, Nup133, Nup107 and Nup96.
This complex plays a role in RNA export and in tethering Nup98 and Nup153 to the nucleus
Subcellular location: Nucleus, nuclear pore complex. Chromosome, centromere, kinetochore. Note=Located on both the
cytoplasmic and nuclear sides of the nuclear pore. During mitosis, localizes to the kinetochores
Sequence caution: Sequence=BAA91885.1; Type=Erroneous initiation; Sequence=BAB14106.1; Type=Erroneous initiation;
4 PDB 3D structures from and Proteopedia for NUP133:
1XKS (3D)        3CQC (3D)        3CQG (3D)        3I4R (3D)    
Secondary accessions: B2RAZ8 Q5T8N0 Q9H9W2 Q9NV71 Q9NVC4

Explore the universe of human proteins at neXtProt for NUP133: NX_Q8WUM0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8WUM0

  • NUP133 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_060700.2  
    ENSEMBL proteins: 
     ENSP00000261396   ENSP00000355640   ENSP00000355639   ENSP00000443496  
    Reactome Protein details: Q8WUM0
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: NUP133
    OriGene Protein Over-expression Lysate: NUP133
    OriGene Custom Protein Services for NUP133 
    GenScript Custom Purified and Recombinant Proteins Services for NUP133
    Novus Biologicals NUP133 Protein
    Novus Biologicals NUP133 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NUP133

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000777colocalizes with condensed chromosome kinetochore IDA17098863
    GO:0000940colocalizes with condensed chromosome outer kinetochore IDA17363900
    GO:0005635nuclear envelope TAS--
    GO:0005643nuclear pore IDA17098863
    GO:0005829cytosol TAS--


    NUP133 for ontologies           About GeneDecksing



    NUP133 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NUP133 
    GenScript Custom Superior Antibodies Services for NUP133
    Novus Biologicals NUP133 Antibodies
    Abcam antibodies for NUP133 
    Uscn Antibodies for NUP133
    ThermoFisher Antibodies for NUP133

    Assay Products for NUP133: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NUP133
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for NUP133


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    NUP133 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR014908 Nucleoporin_Nup133/Nup155_N
     IPR015943 WD40/YVTN_repeat-like_dom
     IPR007187 Nucleoporin_Nup133/Nup155_C

    Graphical View of Domain Structure for InterPro Entry Q8WUM0

    ProtoNet protein and cluster: Q8WUM0

    1 Blocks protein family: IPB007187 Nup133 nucleoporin

    UniProtKB/Swiss-Prot: NU133_HUMAN, Q8WUM0
    Similarity: Belongs to the nucleoporin Nup133 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: NU133_HUMAN, Q8WUM0
    Function: Involved in poly(A)+ RNA transport

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: NUP133
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NUP133
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate NUP133:
    hsa-miR-301b hsa-miR-301a hsa-miR-3666 hsa-miR-454 hsa-miR-4295 hsa-miR-130a hsa-miR-3148 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidNUP133 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NUP133 (see all 4)
    OriGene shRNA RFP: NUP133
    OriGene siRNA: NUP133
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUP133

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NUP133

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUP133 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUP133 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NUP133 (NM_018230)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUP133
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUP133 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NUP133
    Search LifeMap BioReagents cell lines for NUP133

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUP133

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005487nucleocytoplasmic transporter activity IDA11684705
    GO:0005515protein binding IPI11564755


    NUP133 for ontologies           About GeneDecksing


    6 GenomeRNAi human phenotypes for NUP133:
     Decreased Tat-dependent transc  Decreased p24 protein expressi  Decreased viability of wild-ty  G0/1 arrest 
     Increased G1 DNA content  Increased gamma-H2AX phosphory 

    Animal Models:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nup133):
     cardiovascular system  embryogenesis  growth/size  homeostasis/metabolism  mortality/aging 
     nervous system 

    NUP133 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/13 super-pathways (see all 13About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus
    8/11 pathways (see all 11)
    Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus1.00
    Interactions of Vpr with host cellular proteins0.70
    Nuclear import of Rev protein0.76
    Glucose transport0.57
    Vpr-mediated nuclear import of PICs0.76
    Hexose transport0.55
    Regulation of Glucokinase by Glucokinase Regulatory Protein0.75
    ISG15 antiviral mechanism0.49
    2M Phase
    M Phase1.00
    Mitotic Anaphase0.85
    Mitotic M-M/G1 phases0.88
    Separation of Sister Chromatids0.80
    Mitotic Metaphase and Anaphase0.85
    3Resolution of Sister Chromatid Cohesion
    Resolution of Sister Chromatid Cohesion1.00
    Mitotic Prometaphase0.93
    Kinetochore assembly0.96
    4Cytokine Signaling in Immune system
    Cytokine Signaling in Immune system1.00
    Interferon Signaling0.61
    5HIV Infection
    HIV Infection1.00
    Host Interactions of HIV factors0.64

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/33        Reactome Pathways for NUP133 (see all 33)
        Mitotic Prometaphase
    Interactions of Rev with host cellular proteins
    Rev-mediated nuclear export of HIV-1 RNA
    Interferon Signaling
    Vpr-mediated nuclear import of PICs


    1         Kegg Pathway  (Kegg details for NUP133):
        RNA transport


    NUP133 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NUP133

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/138 Interacting proteins for NUP133 (Q8WUM01, 2, 3 ENSP000002613964) via UniProtKB, MINT, STRING, and/or I2D (see all 138)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NUP107P577401, 2, 3, ENSP000002291794EBI-295695,EBI-295687 MINT-4788188 MINT-4788150 I2D: score=3 STRING: ENSP00000229179
    AHCTF1Q8WYP52, 3, ENSP000003757054MINT-4301609 I2D: score=1 STRING: ENSP00000375705
    CENPFP494542, 3, ENSP000003559224MINT-4788132 MINT-4788150 I2D: score=2 STRING: ENSP00000355922
    NUP98P529483, ENSP000003160324I2D: score=4 STRING: ENSP00000316032
    MYCP011063, ENSP000003672074I2D: score=3 STRING: ENSP00000367207
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000087M phase of mitotic cell cycle TAS--
    GO:0000236mitotic prometaphase TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006406mRNA export from nucleus IDA11684705


    NUP133 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NUP133
    Search CenterWatch for drugs/clinical trials and news about NUP133 / NU133 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NUP133 gene: 
    NM_018230.2  

    Unigene Cluster for NUP133:

    Nucleoporin 133kDa
    Hs.12457  [show with all ESTs]
    Unigene Representative Sequence: AK001676
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261396(uc001htn.3) ENST00000366679 ENST00000490352 ENST00000485119
    ENST00000366678 ENST00000537506

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: NUP133
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NUP133
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate NUP133:
    hsa-miR-301b hsa-miR-301a hsa-miR-3666 hsa-miR-454 hsa-miR-4295 hsa-miR-130a hsa-miR-3148 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidNUP133 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NUP133 (see all 4)
    OriGene shRNA RFP: NUP133
    OriGene siRNA: NUP133
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUP133
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUP133 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUP133 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NUP133 (NM_018230)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUP133
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUP133 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUP133
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NUP133
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUP133
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUP133

    Additional cDNA sequence: 

    AF052123.1 AK001676.1 AK001754.1 AK022572.1 AK092339.1 AK304061.1 AK304861.1 AK314431.1 
    BC020107.1 

    16 DOTS entries:

    DT.95212793  DT.455814  DT.95212752  DT.70102365  DT.100784364  DT.75186573  DT.95212786  DT.95212787 
    DT.100774395  DT.121402674  DT.75127098  DT.86857397  DT.91718225  DT.91808639  DT.92449712  DT.91660243 

    24/303 AceView cDNA sequences (see all 303):

    BX279556 AK022572 C01331 R19923 BG779519 BQ086193 CF135835 AA534880 
    AI914414 AU133448 CK903624 BP362868 CB306773 BF102972 CA426518 AI805453 
    BG150517 AI225068 AI086357 Z44088 BX494306 CR593569 AA788599 AL583194 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for NUP133 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21a · 21b · 21c ^
    SP1:                    -                 -           -                                                                       -           -                     
    SP2:                    -                 -           -                                                                       -           -                     
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                      -                     
    SP5:                                                                                                                                                            

    ExUns: 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30a · 30b · 30c
    SP1:                                            -                                       
    SP2:        -     -     -                       -                                       
    SP3:                                                                                    
    SP4:                                                                                    
    SP5:              -                                                                     


    ECgene alternative splicing isoforms for NUP133

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NUP133 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGAGCTTGAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See NUP133 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NUP133

    SOURCE GeneReport for Unigene cluster: Hs.12457
        SABiosciences Custom PCR Arrays for NUP133
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUP133
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NUP133
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUP133
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUP133
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUP133

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NUP133 gene from 9/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nup1331 , 5 nucleoporin 1331, 5 80.38(n)1
    83.29(a)1
      8 (72.27 cM)5
    2348651  NM_172288.21  NP_758492.21 
     1238971235 
    chicken
    (Gallus gallus)
    Aves NUP1331 nucleoporin 133kDa 74.32(n)
    73.74(a)
      421535  XM_419576.3  XP_419576.3 
    lizard
    (Anolis carolinensis)
    Reptilia NUP1336
    --
    66(a)
    1 ↔ 1
    1(222223311-222265816)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.94852 Xenopus laevis transcribed sequence with weak similarity more 72.8(n)    BX842923.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa04e092 Danio rerio cDNA clone MGC55311 IMAGE2600558, complete more 72.23(n)    BC052764.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG69583
    Nup1331
    Nucleoporin 1331 26(a)3
    41.39(n)1
    28.48(a)1
      94C13
    426801  NM_142823.21  NP_651080.21 
    worm
    (Caenorhabditis elegans)
    Secernentea npp-156
    Nuclear pore complex protein 15
    17(a)
    1 ↔ 1
    III(7928984-7932929)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G051206
    nucleoporin, Nup133/Nup155-like protein
    15(a)
    1 ↔ 1
    2(1841887-1846912)
    rice
    (Oryza sativa)
    Liliopsida --
    nucleoporin, putative, expressed
    16(a)
    1 ↔ 1
    3(6572198-6579719)


    ENSEMBL Gene Tree for NUP133 (if available)
    TreeFam Gene Tree for NUP133 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1206 NCBI SNPs in NUP133 are shown (see all 1206    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs731122681,2
    C,--200067566(+) GATGCT/CGGGCT 1 -- ds50012Minor allele frequency- C:0.24WA 120
    rs801451871,2
    C,--200067697(+) TCCAAC/ACTCTG 1 -- ds50011Minor allele frequency- A:0.50NA 2
    rs754431141,2
    C,--200068191(+) CCCTAG/AATTCT 1 -- ut312Minor allele frequency- A:0.05CSA WA 120
    rs118099771,2
    C,F,H,--200068841(+) TATAAC/TGTCAC 1 -- int111Minor allele frequency- T:0.04NS EA NA WA 1182
    rs2002391031,2
    C--200069411(+) TGGTTC/TTTTTT 1 -- int10--------
    rs795082501,2
    C,F,--200070245(+) NNNNAT/CGAAAT 1 -- int11Minor allele frequency- C:0.07NA 120
    rs731122701,2
    C,--200070311(+) TATTGT/GACATG 1 -- int12Minor allele frequency- G:0.19WA 120
    rs787233981,2
    F,--200070374(+) CGCACG/ACCTTA 1 -- int11Minor allele frequency- A:0.08WA 118
    rs1122935281,2
    C--200070616(+) TTTTTT/AAAATA 1 -- int12Minor allele frequency- A:0.00WA CSA 3
    rs618242981,2
    C,F,--200071542(+) GTAACA/GTATTC 1 -- int13Minor allele frequency- G:0.05NA 124

    HapMap Linkage Disequilibrium report for NUP133 (229577044 - 229644103 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NUP133: --
    Locus Specific Mutation Databases (LSDB): NUP133

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NUP133
    DNA2.0 Custom Variant and Variant Library Synthesis for NUP133

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NUP133 for disorders           About GeneDecksing

    OMIM gene information: 607613    OMIM disorders: --

    1 disease for NUP133:    About MalaCards
    hepatitis

    Human Genome Epidemiology (HuGE) Navigator: NUP133 (4 documents)

    Export disorders for NUP133 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NUP133 gene, integrated from 9 sources (see all 48):
    (articles sorted by number of sources associating them with NUP133)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export. (PubMed id 11684705)1, 2, 3, 9 Vasu S.... Forbes D.J. (2001)
    2. An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells. (PubMed id 11564755)1, 2, 9 Belgareh N.... Doye V. (2001)
    3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Structural and functional analysis of Nup133 domains reveals modular building blocks of the nuclear pore complex. (PubMed id 15557116)1, 2 Berke I.C.... Schwartz T.U. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Structural and functional studies of Nup107/Nup133 interaction and its implications for the architecture of the nuclear pore complex. (PubMed id 18570875)1, 9 Boehmer T....Schwartz T.U. (2008)
    9. Architectural nucleoporins Nup157/170 and Nup133 are structurally related and descend from a second ancestral element. (PubMed id 19674973)1, 9 Whittle J.R. and Schwartz T.U. (2009)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55746 HGNC: 18016 AceView: NUP133 Ensembl:ENSG00000069248 euGenes: HUgn55746
    ECgene: NUP133 Kegg: 55746 H-InvDB: NUP133

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NUP133 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NUP133 gene:
    Search GeneIP for patents involving NUP133

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for NUP133  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NUP133   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUP133  
     OriGene Protein Over-expression Lysate for NUP133   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for NUP133   OriGene 3'-UTR Clone for NUP133  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUP133   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUP133  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for NUP133   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NUP133   OriGene Custom Protein Services for NUP133  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NUP133
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NUP133
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUP133
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUP133
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUP133
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUP133
     GenScript Custom Purified and Recombinant Proteins Services for NUP133 GenScript cDNA clones with any tag delivered in your preferred vector for NUP133
     GenScript Custom Assay Services for NUP133 GenScript Custom Superior Antibodies Services for NUP133
     GenScript Custom overexpressing Cell Line Services for NUP133 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NUP133 promoter
     Search Chromatin IP Primers for NUP133
     RT2 qPCR Primer Assay in human, mouse, rat NUP133
     GNC Network for NUP133
     SABiosciences Custom PCR Arrays for NUP133
     Search Tocris compounds for NUP133
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NUP133 antibodies
     NUP133 proteins
     NUP133 lysates
     Antibodies for NUP133
     See all of Abcam's Antibodies, Kits and Proteins for NUP133
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     NUP133 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for NUP133
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUP133
     SwitchGear 3'UTR luciferase reporter plasmids for NUP133
     SwitchGear Promoter luciferase reporter plasmids for NUP133
     ThermoFisher Antibodies for NUP133
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUP133
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NUP133 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4