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Aliases for NUP107 Gene

Aliases for NUP107 Gene

  • Nucleoporin 107kDa 2 3
  • 107 KDa Nucleoporin 3 4
  • Nucleoporin Nup107 3 4
  • NUP84 3 6
  • Nuclear Pore Complex Protein Nup107 3

External Ids for NUP107 Gene

Summaries for NUP107 Gene

Entrez Gene Summary for NUP107 Gene

  • This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is an essential component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for NUP107 Gene

NUP107 (Nucleoporin 107kDa) is a Protein Coding gene. Diseases associated with NUP107 include mesenchymal chondrosarcoma. Among its related pathways are Disease and Cell Cycle, Mitotic. GO annotations related to this gene include nucleocytoplasmic transporter activity and structural constituent of nuclear pore.

UniProtKB/Swiss-Prot for NUP107 Gene

  • Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to the NPC.

Gene Wiki entry for NUP107 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP107 Gene

Genomics for NUP107 Gene

Genomic Location for NUP107 Gene

68,686,734 bp from pter
68,745,809 bp from pter
59,076 bases
Plus strand

Genomic View for NUP107 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUP107 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP107 Gene

Regulatory Elements for NUP107 Gene

Proteins for NUP107 Gene

  • Protein details for NUP107 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nuclear pore complex protein Nup107
    Protein Accession:
    Secondary Accessions:
    • B4DZ67
    • Q6PJE1

    Protein attributes for NUP107 Gene

    925 amino acids
    Molecular mass:
    106374 Da
    Quaternary structure:
    • Part of the nuclear pore complex (NPC). Forms part of the Nup160 subcomplex in the nuclear pore which is composed of NUP160, NUP133, NUP107 and Nup96; this complex plays a role in RNA export and in tethering Nup98 and NUP153 to the nucleus. Does not interact with TPR.

    Three dimensional structures from OCA and Proteopedia for NUP107 Gene

    Alternative splice isoforms for NUP107 Gene


neXtProt entry for NUP107 Gene

Proteomics data for NUP107 Gene at MOPED

Post-translational modifications for NUP107 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys85, Lys305, Lys332, Lys348, Lys382, Lys408, Lys637, Lys690, and Lys773

Other Protein References for NUP107 Gene

No data available for DME Specific Peptides for NUP107 Gene

Domains for NUP107 Gene

Protein Domains for NUP107 Gene



  • Belongs to the nucleoporin Nup84/Nup107 family.:
    • P57740
genes like me logo Genes that share domains with NUP107: view

No data available for Gene Families for NUP107 Gene

Function for NUP107 Gene

Molecular function for NUP107 Gene

UniProtKB/Swiss-Prot Function: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to the NPC.

Gene Ontology (GO) - Molecular Function for NUP107 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005487 nucleocytoplasmic transporter activity IDA 11684705
GO:0005515 protein binding IPI 11564755
GO:0017056 structural constituent of nuclear pore IMP 15229283
genes like me logo Genes that share ontologies with NUP107: view
genes like me logo Genes that share phenotypes with NUP107: view

miRNA for NUP107 Gene

miRTarBase miRNAs that target NUP107

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NUP107 Gene

Localization for NUP107 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP107 Gene

Nucleus membrane. Nucleus, nuclear pore complex. Chromosome, centromere, kinetochore. Note=Located on both the cytoplasmic and nuclear sides of the NPC core structure. During mitosis, localizes to the kinetochores. Dissociates from the dissasembled NPC structure late during prophase of mitosis.

Subcellular locations from

Jensen Localization Image for NUP107 Gene COMPARTMENTS Subcellular localization image for NUP107 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NUP107 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 colocalizes_with kinetochore IDA 17363900
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus --
GO:0005635 nuclear envelope TAS --
GO:0005643 nuclear pore IDA 11564755
genes like me logo Genes that share ontologies with NUP107: view

Pathways for NUP107 Gene

SuperPathways for NUP107 Gene

genes like me logo Genes that share pathways with NUP107: view

Pathways by source for NUP107 Gene

1 BioSystems pathway for NUP107 Gene
47 Reactome pathways for NUP107 Gene
1 KEGG pathway for NUP107 Gene

Gene Ontology (GO) - Biological Process for NUP107 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0005975 carbohydrate metabolic process TAS --
GO:0006406 mRNA export from nucleus IDA 11684705
GO:0006810 transport --
GO:0007077 mitotic nuclear envelope disassembly TAS --
genes like me logo Genes that share ontologies with NUP107: view

Transcripts for NUP107 Gene

Unigene Clusters for NUP107 Gene

Nucleoporin 107kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUP107 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - - - -
SP2: - - - - -
SP5: - -

ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28
SP2: - -

Relevant External Links for NUP107 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NUP107 Gene

mRNA expression in normal human tissues for NUP107 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUP107 Gene

SOURCE GeneReport for Unigene cluster for NUP107 Gene Hs.524574

genes like me logo Genes that share expressions with NUP107: view

Orthologs for NUP107 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NUP107 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NUP107 36
  • 99.21 (n)
  • 98.92 (a)
NUP107 37
  • 99 (a)
(Bos Taurus)
Mammalia NUP107 36
  • 91.85 (n)
  • 94.26 (a)
NUP107 37
  • 94 (a)
(Canis familiaris)
Mammalia NUP107 36
  • 91.16 (n)
  • 93.61 (a)
NUP107 37
  • 94 (a)
(Mus musculus)
Mammalia Nup107 36
  • 84.81 (n)
  • 91.45 (a)
Nup107 16
Nup107 37
  • 91 (a)
(Monodelphis domestica)
Mammalia -- 37
  • 82 (a)
-- 37
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia NUP107 37
  • 83 (a)
(Rattus norvegicus)
Mammalia Nup107 36
  • 85.03 (n)
  • 92.1 (a)
(Gallus gallus)
Aves NUP107 36
  • 76.19 (n)
  • 81.24 (a)
NUP107 37
  • 78 (a)
(Anolis carolinensis)
Reptilia NUP107 37
  • 65 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16196 36
tropical clawed frog
(Silurana tropicalis)
Amphibia nup107 36
  • 71.25 (n)
  • 75.91 (a)
Str.7316 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4383 36
(Danio rerio)
Actinopterygii nup107 36
  • 65.89 (n)
  • 68.73 (a)
nup107 37
  • 67 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001685 36
  • 44.22 (n)
  • 37.98 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nup107 36
  • 43.09 (n)
  • 35.94 (a)
Nup107 37
  • 33 (a)
BcDNA:LD18761 38
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NUP84 37
  • 20 (a)
NUP84 39
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 38 (a)
-- 37
  • 40 (a)
Species with no ortholog for NUP107:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUP107 Gene

Gene Tree for NUP107 (if available)
Gene Tree for NUP107 (if available)

Paralogs for NUP107 Gene

No data available for Paralogs for NUP107 Gene

Variants for NUP107 Gene

Sequence variations from dbSNP and Humsavar for NUP107 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs2059111 -- 68,692,441(-) CCACC(A/T)TACCC intron-variant
rs2259588 -- 68,689,025(-) TGTTT(C/T)CGTGC synonymous-codon, reference
rs2259592 -- 68,688,889(-) CACAG(C/T)TGGAG intron-variant
rs2261987 -- 68,701,333(-) ATTTA(A/G)CCAAT intron-variant
rs2431658 -- 68,716,731(-) AAGAG(C/G)CATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUP107 Gene

Variant ID Type Subtype PubMed ID
nsv522941 CNV Gain 19592680
nsv510302 CNV Loss 20534489
nsv759 CNV Loss 18451855

Relevant External Links for NUP107 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for NUP107 Gene

(1) University of Copenhagen DISEASES for NUP107 Gene

Relevant External Links for NUP107

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with NUP107: view

No data available for UniProtKB/Swiss-Prot for NUP107 Gene

Publications for NUP107 Gene

  1. Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export. (PMID: 11684705) Vasu S. … Forbes D.J. (J. Cell Biol. 2001) 3 4 23
  2. Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket. (PMID: 15229283) Krull S. … Cordes V.C. (Mol. Biol. Cell 2004) 3 4 23
  3. Depletion of a single nucleoporin, Nup107, prevents the assembly of a subset of nucleoporins into the nuclear pore complex. (PMID: 12552102) Boehmer T. … Zhong H. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4
  4. The conserved Nup107-160 complex is critical for nuclear pore complex assembly. (PMID: 12705868) Walther T.C. … Doye V. (Cell 2003) 2 3
  5. Direct interaction with nup153 mediates binding of Tpr to the periphery of the nuclear pore complex. (PMID: 12802065) Hase M.E. … Cordes V.C. (Mol. Biol. Cell 2003) 3 4

Products for NUP107 Gene

Sources for NUP107 Gene

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