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Aliases for NUMBL Gene

Aliases for NUMBL Gene

  • Numb Homolog (Drosophila)-Like 2 3
  • Numb-Related Protein 3 4
  • NUMB-R 3 4
  • NUMBR 3 6
  • NBL 3 6
  • Numb (Drosophila) Homolog-Like 2
  • Numb Homolog-Like 3
  • Numb-Like Protein 3
  • NUMBLIKE 3
  • TNRC23 3
  • CAG3A 3
  • CTG3a 3

External Ids for NUMBL Gene

Summaries for NUMBL Gene

GeneCards Summary for NUMBL Gene

NUMBL (Numb Homolog (Drosophila)-Like) is a Protein Coding gene. Among its related pathways are Notch signaling pathway (KEGG) and Notch signaling pathway (KEGG). An important paralog of this gene is GULP1.

UniProtKB/Swiss-Prot for NUMBL Gene

  • Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the Lys-48-linked polyubiquitination and degradation of TRAF6 in cortical neurons.

Gene Wiki entry for NUMBL Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUMBL Gene

Genomics for NUMBL Gene

Genomic Location for NUMBL Gene

Start:
40,665,905 bp from pter
End:
40,691,757 bp from pter
Size:
25,853 bases
Orientation:
Minus strand

Genomic View for NUMBL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUMBL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUMBL Gene

Regulatory Elements for NUMBL Gene

Proteins for NUMBL Gene

  • Protein details for NUMBL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6R0-NUMBL_HUMAN
    Recommended name:
    Numb-like protein
    Protein Accession:
    Q9Y6R0
    Secondary Accessions:
    • Q7Z4J9

    Protein attributes for NUMBL Gene

    Size:
    609 amino acids
    Molecular mass:
    64891 Da
    Quaternary structure:
    • Interacts (via PTB domain) with MAP3K7IP2 (via C-terminal). Interacts (via C-terminal) with TRAF6 (via TRAF domains). Associates with EPS15 and NOTCH1.

    Three dimensional structures from OCA and Proteopedia for NUMBL Gene

neXtProt entry for NUMBL Gene

Proteomics data for NUMBL Gene at MOPED

Post-translational modifications for NUMBL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NUMBL Gene

Domains for NUMBL Gene

UniProtKB/Swiss-Prot:

NUMBL_HUMAN
Domain:
  • The PTB domain is necessary for the inhibition of MAP3K7IP2-mediated activation of NF-kappa-B:
    • Q9Y6R0
  • Contains 1 PID domain.:
    • Q9Y6R0
genes like me logo Genes that share domains with NUMBL: view

No data available for Gene Families for NUMBL Gene

Function for NUMBL Gene

Molecular function for NUMBL Gene

GENATLAS Biochemistry: Drosophila numb homolog-like,signal transducer Eps15-2 of yeast,nematode homolog
UniProtKB/Swiss-Prot Function: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the Lys-48-linked polyubiquitination and degradation of TRAF6 in cortical neurons.

Gene Ontology (GO) - Molecular Function for NUMBL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16713569
genes like me logo Genes that share ontologies with NUMBL: view
genes like me logo Genes that share phenotypes with NUMBL: view

Animal Models for NUMBL Gene

MGI Knock Outs for NUMBL:

miRNA for NUMBL Gene

miRTarBase miRNAs that target NUMBL

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NUMBL Gene

Localization for NUMBL Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUMBL Gene

Cytoplasm. Note=Symmetrically distributed throughout the cytoplasm in non dividing neuroblasts of the CNS. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUMBL Gene COMPARTMENTS Subcellular localization image for NUMBL gene
Compartment Confidence
nucleus 3
extracellular 1

Gene Ontology (GO) - Cellular Components for NUMBL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NUMBL: view

Pathways for NUMBL Gene

genes like me logo Genes that share pathways with NUMBL: view

Pathways by source for NUMBL Gene

2 BioSystems pathways for NUMBL Gene
1 KEGG pathway for NUMBL Gene

Gene Ontology (GO) - Biological Process for NUMBL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development TAS 9303539
GO:0007405 neuroblast proliferation --
GO:0007409 axonogenesis IEA --
GO:0019221 cytokine-mediated signaling pathway IDA 18299187
GO:0019538 protein metabolic process IDA 20079715
genes like me logo Genes that share ontologies with NUMBL: view

Transcripts for NUMBL Gene

Unigene Clusters for NUMBL Gene

Numb homolog (Drosophila)-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUMBL Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9
SP1: -
SP2: -
SP3:

Relevant External Links for NUMBL Gene

GeneLoc Exon Structure for
NUMBL
ECgene alternative splicing isoforms for
NUMBL

Expression for NUMBL Gene

mRNA expression in normal human tissues for NUMBL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUMBL Gene

SOURCE GeneReport for Unigene cluster for NUMBL Gene Hs.326953

genes like me logo Genes that share expressions with NUMBL: view

Orthologs for NUMBL Gene

This gene was present in the common ancestor of animals.

Orthologs for NUMBL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUMBL 36
  • 99.36 (n)
  • 99.42 (a)
NUMBL 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NUMBL 36
  • 90.4 (n)
  • 95.12 (a)
NUMBL 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUMBL 36
  • 90.41 (n)
  • 95.15 (a)
NUMBL 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Numbl 36
  • 89.24 (n)
  • 95.86 (a)
Numbl 16
Numbl 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NUMBL 37
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUMBL 37
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Numbl 36
  • 88.93 (n)
  • 95.23 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 16 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia NUMBL 37
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia numbl 36
  • 63.14 (n)
  • 68.27 (a)
zebrafish
(Danio rerio)
Actinopterygii numbl 36
  • 63.47 (n)
  • 64.2 (a)
numbl 37
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta numb 37
  • 38 (a)
OneToMany
numb 38
  • 56 (a)
worm
(Caenorhabditis elegans)
Secernentea num-1 37
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9113 37
  • 44 (a)
OneToMany
Species with no ortholog for NUMBL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUMBL Gene

ENSEMBL:
Gene Tree for NUMBL (if available)
TreeFam:
Gene Tree for NUMBL (if available)

Paralogs for NUMBL Gene

Paralogs for NUMBL Gene

Selected SIMAP similar genes for NUMBL Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with NUMBL: view

Variants for NUMBL Gene

Sequence variations from dbSNP and Humsavar for NUMBL Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2042935 -- 40,675,514(-) taatt(A/T)attta intron-variant
rs2250994 -- 40,670,498(+) GATAC(A/G)CCTGT intron-variant
rs2561537 -- 40,687,675(-) GCGGG(C/T)GCCTG intron-variant
rs2561539 -- 40,683,902(-) TACTC(A/G)CAAGG intron-variant
rs2561540 -- 40,683,628(-) ACGGC(A/G)TGGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUMBL Gene

Variant ID Type Subtype PubMed ID
dgv3869n71 CNV Loss 21882294
dgv3871n71 CNV Loss 21882294
nsv2489 CNV Loss 18451855
nsv820299 CNV Loss 19587683

Relevant External Links for NUMBL Gene

HapMap Linkage Disequilibrium report
NUMBL
Human Gene Mutation Database (HGMD)
NUMBL

Disorders for NUMBL Gene

(1) University of Copenhagen DISEASES for NUMBL Gene

Relevant External Links for NUMBL

Genetic Association Database (GAD)
NUMBL
Human Genome Epidemiology (HuGE) Navigator
NUMBL
genes like me logo Genes that share disorders with NUMBL: view

No data available for UniProtKB/Swiss-Prot for NUMBL Gene

Publications for NUMBL Gene

  1. Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module. (PMID: 9303539) Salcini A.E. … Di Fiore P.P. (Genes Dev. 1997) 2 3 4
  2. Mutation and copy number analysis of LNX1 and Numbl in nervous system tumors. (PMID: 18940473) Blom T. … Nupponen N.N. (Cancer Genet. Cytogenet. 2008) 3 49
  3. NUMBL interacts with TRAF6 and promotes the degradation of TRAF6. (PMID: 20079715) Zhou L. … Huo K. (Biochem. Biophys. Res. Commun. 2010) 3 4
  4. Analysis of coding-polymorphisms in NOTCH-related genes reveals NUMBL poly-glutamine repeat to be associated with schizophrenia in Brazilian and Danish subjects. (PMID: 16899352) Passos Gregorio S. … Dias-Neto E. (Schizophr. Res. 2006) 3 49
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for NUMBL Gene

Sources for NUMBL Gene

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