Aliases for NUMBL Gene
External Ids for NUMBL Gene
Previous GeneCards Identifiers for NUMBL Gene
GeneCards Summary for NUMBL Gene
NUMBL (NUMB Like, Endocytic Adaptor Protein) is a Protein Coding gene. Diseases associated with NUMBL include autonomic nervous system neoplasm and peripheral nervous system neoplasm. Among its related pathways are Notch signaling pathway (KEGG). An important paralog of this gene is GULP1.
UniProtKB/Swiss-Prot for NUMBL Gene
Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the Lys-48-linked polyubiquitination and degradation of TRAF6 in cortical neurons.