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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NUMB Gene

protein-coding GIFtS: 65
GCID: GC14M073741

numb homolog (Drosophila)

(Previous names: numb (Drosophila) homolog, chromosome 14 open reading frame...)
(Previous symbol: C14orf41)

Explore 11 diseases affiliated with
NUMB via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Numb Homolog (Drosophila)¹ ²		Numb (Drosophila) Homolog¹
C14orf41¹ ²		C14_5527¹
H-Numb¹		Protein Numb Homolog²
S171² ⁵		Protein S171³
Chromosome 14 Open Reading Frame 41¹

External Ids:	HGNC: 8060¹	Entrez Gene: 8650²	Ensembl: ENSG00000133961⁷	OMIM: 603728⁵	UniProtKB: P49757³

Export aliases for NUMB gene to outside databases

Previous GC identifers: GC14M071246 GC14M067537 GC14M071731 GC14M072811 GC14M053907

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NUMB:

The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded

protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has

been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been

found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NUMB_HUMAN, P49757

Function: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural

progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over

neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis.

Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and

ependymal wall integrity. May also mediate local repair of brain ventricular wall damage

Gene Wiki entry for NUMB

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NUMB gene promoter:
AP-2alpha isoform 3 AP-2alpha isoform 2 AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NUMB promoter sequence

Search SABiosciences Chromatin IP Primers for NUMB

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUMB

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3 Ensembl cytogenetic band: 14q24.3 HGNC cytogenetic band: 14q24.3

NUMB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUMB gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M073741: view genomic region (about GC identifiers)

Start:	73,741,815 bp from pter	End:	73,930,348 bp from pter
Size:	188,534 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NUMB_HUMAN, P49757 (See protein sequence)

Recommended Name: Protein numb homolog

Size: 651 amino acids; 70804 Da

Subunit: Interacts with CDH1 and TFAP2B (By similarity). Interacts with EPS15, LNX and NOTCH1. May interact with

DUOXA1. Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis

Subcellular location: Membrane; Peripheral membrane protein

Sequence caution: Sequence=AAH20788.1; Type=Miscellaneous discrepancy; Note=Intron retention;

Secondary accessions: B4E2B1 Q6NUQ7 Q86SY1 Q8WW73 Q9UBG1 Q9UEQ4 Q9UKE8 Q9UKE9 Q9UKF0 Q9UQJ4

Alternative splicing: 4 isoforms: P49757-1 P49757-2 P49757-3 P49757-4

Explore the universe of human proteins at neXtProt for NUMB: NX_P49757

Post-translational modifications:

Phosphorylated on Ser-276 and Ser-295 by CaMK1 (By similarity)¹

Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation (By similarity).

Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P49757

NUMB Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001005743.1 NP_001005744.1 NP_001005745.1 NP_003735.3

ENSEMBL proteins:

ENSP00000452416 ENSP00000348644 ENSP00000451117 ENSP00000451300 ENSP00000451513

ENSP00000451625 ENSP00000452888 ENSP00000453209 ENSP00000452069 ENSP00000450817

ENSP00000451326 ENSP00000452357 ENSP00000451374 ENSP00000451559 ENSP00000451959

ENSP00000347169 ENSP00000352563 ENSP00000394025 ENSP00000446001 ENSP00000441258

Reactome Protein details: P49757
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 3): NUMB OriGene Protein Over-expression Lysate (see all 3): NUMB OriGene Custom Protein Services for NUMB
	GenScript Custom Purified and Recombinant Proteins Services for NUMB
	Novus Biologicals NUMB Proteins Novus Biologicals NUMB Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NUMB

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	--	--
GO:0005769	early endosome	IEA	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	7596406

NUMB for ontologies About GeneDecksing

NUMB Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of NUMB
	R&D Systems Antibodies for NUMB
	Cell Signaling Technology (CST) Antibodies for NUMB
	OriGene Antibodies (see all 6): NUMB OriGene Custom Antibody Services for NUMB
	GenScript Superior Antibodies for NUMB
	Novus Biologicals NUMB Antibodies
	Search for Antibodies for NUMB at Abcam
	Uscn Antibodies for NUMB
	ThermoFisher Antibodies for NUMB

Assay Products for NUMB:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for NUMB
	GenScript Custom Assay Services for NUMB
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NUMB

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NUMB for domains About GeneDecksing

4 InterPro domains/families:

IPR011993 PH_like_dom

IPR010449 Numb_domain

IPR006020 PTyr_interaction_dom

IPR016698 Numb/numb-like

Graphical View of Domain Structure for InterPro Entry P49757

ProtoNet protein and cluster: P49757

2 Blocks protein families:

IPB006020 Phosphotyrosine interaction domain

IPB010449 NUMB phenylalanine-rich

UniProtKB/Swiss-Prot: NUMB_HUMAN, P49757

Similarity: Contains 1 PID domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: NUMB_HUMAN, P49757

Function: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural

progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over

neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis.

Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and

ependymal wall integrity. May also mediate local repair of brain ventricular wall damage

Genatlas biochemistry entry for NUMB:

Drosophila numb homolog,signal transducer Eps15 of yeast,nematode homolog

miRNA Products:		miRTarBase miRNAs that target NUMB: hsa-mir-31 (MIRT004970)

		OriGene 3'-UTR Clone (see all 4): NUMB Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NUMB
		8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate NUMB (see all 18):
		hsa-miR-429 hsa-miR-146a hsa-miR-1271 hsa-miR-219-5p hsa-miR-374a hsa-miR-410 hsa-miR-508-3p hsa-miR-3119

		SwitchGear 3'UTR luciferase reporter plasmid: NUMB 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NUMB (see all 7) OriGene shRNA RFP: NUMB OriGene siRNA: NUMB
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUMB

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for NUMB

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUMB (see all 8) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUMB (see all 5) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): NUMB (NM_003744)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUMB
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUMB

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NUMB
		Search LifeMap BioReagents cell lines for NUMB

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUMB

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--
GO:0008013	beta-catenin binding	IEA	--
GO:0045294	alpha-catenin binding	IEA	--
GO:0045296	cadherin binding	IEA	--

NUMB for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for NUMB:

Synthetic lethal with Ras

Animal Models:
Mouse knock-outs for NUMB: Numb^tm1.1Ynj Numb^tm1.1Zili
12 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Numb):

behavior/neurological	cardiovascular system	cellular	embryogenesis	growth/size
hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	mortality/aging	nervous system
normal	reproductive system

NUMB for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant

Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant	1.00	Signaling by NOTCH1 HD Domain Mutants in Cancer	1.00
Signaling by NOTCH1 PEST Domain Mutants in Cancer	1.00	FBXW7 Mutants and NOTCH1 in Cancer	1.00
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	1.00	Signaling by NOTCH1	1.00
Signaling by NOTCH1 in Cancer	1.00	Signaling by NOTCH	0.77

Axon guidance

	Axon guidance	1.00			L1CAM interactions	0.39
	Developmental Biology	0.69			Recycling pathway of L1	0.15

Notch Signaling Pathway

	Notch Signaling Pathway	1.00			Delta-Notch Signaling Pathway	0.27
	Notch signaling pathway	0.82

Wnt / Hedgehog / Notch

Wnt / Hedgehog / Notch

1.00

Neuroscience

Neuroscience

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for NUMB

Molecular Mechanisms of Cancer

2 Cell Signaling Technology (CST) Pathways for NUMB

	Wnt / Hedgehog / Notch
	Neuroscience

4 BioSystems Pathways for NUMB

	Notch Signaling Pathway
	Delta-Notch Signaling Pathway
	Notch signaling pathway
	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)

5/15 Reactome Pathways for NUMB (see all 15)

	L1CAM interactions
	Signaling by NOTCH
	Developmental Biology
	FBXW7 Mutants and NOTCH1 in Cancer
	Signaling by NOTCH1 HD Domain Mutants in Cancer

1 Kegg Pathway (Kegg details for NUMB):

Notch signaling pathway

NUMB for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NUMB

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/43 Interacting proteins for NUMB (P49757^{2, 3} ENSP00000347169⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 43)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PRKCZ	Q05513²^,³, ENSP00000367830⁴	MINT-4298232 MINT-4298218 MINT-4298249 MINT-4298283 I2D: score=1 STRING: ENSP00000367830
EPS15	P42566²^,³, ENSP00000360798⁴	MINT-17946 MINT-17947 I2D: score=5 STRING: ENSP00000360798
AP2A1	O95782²^,³, ENSP00000351926⁴	MINT-4298264 I2D: score=2 STRING: ENSP00000351926
EGFR	P00533²^,³, ENSP00000275493⁴	MINT-74593 I2D: score=2 STRING: ENSP00000275493
LNX1	Q8TBB1³, ENSP00000263925⁴	I2D: score=5 STRING: ENSP00000263925

About this table

Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007219	Notch signaling pathway	TAS	--
GO:0007399	nervous system development	--	--
GO:0007405	neuroblast proliferation	--	--
GO:0007409	axonogenesis	--	--
GO:0007411	axon guidance	TAS	--

NUMB for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NUMB
Search CenterWatch for drugs/clinical trials and news about NUMB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NUMB gene (4 alternative transcripts):

NM_001005743.1 NM_001005744.1 NM_001005745.1 NM_003744.5

Unigene Clusters for NUMB:

Numb homolog (Drosophila)

Hs.525443 [show with all ESTs], Hs.654609 [show with all ESTs], Hs.714879

Unigene Representative Sequences: AK055876, AK226069, AK294591

18/34 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 34):

ENST00000554546(uc010ttz.1 uc010arp.1 uc010arr.1 uc001xoa.1 uc001xob.1)

ENST00000356296(uc001xod.1) ENST00000557597 ENST00000555238(uc010aro.1 uc010arq.1 uc001xny.1 uc001xnz.1 uc001xoc.1 uc010ars.1)

ENST00000556772 ENST00000555394(uc001xof.1 uc001xog.3) ENST00000559312

ENST00000560335 ENST00000555738 ENST00000554521 ENST00000554014 ENST00000553997

ENST00000557486 ENST00000555859 ENST00000555307 ENST00000554394 ENST00000554315(uc001xoh.1)

ENST00000556989

miRNA Products:		OriGene 3'-UTR Clone (see all 4): NUMB Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NUMB
		8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate NUMB (see all 18):
		hsa-miR-429 hsa-miR-146a hsa-miR-1271 hsa-miR-219-5p hsa-miR-374a hsa-miR-410 hsa-miR-508-3p hsa-miR-3119

		SwitchGear 3'UTR luciferase reporter plasmid: NUMB 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NUMB (see all 7) OriGene shRNA RFP: NUMB OriGene siRNA: NUMB
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		GenScript: all cDNA clones in your preferred vector (see all 4): NUMB (NM_003744)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUMB

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUMB Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat NUMB
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUMB
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUMB

Additional cDNA sequence: AK294591.1

24/35 DOTS entries (see all 35):

DT.417960 DT.100828613 DT.95261004 DT.95261062 DT.95261159 DT.40125317 DT.101958534 DT.95122429

DT.95261058 DT.101984283 DT.40107298 DT.75105596 DT.310351 DT.120758323 DT.100828610 DT.100828614

DT.120758409 DT.100035916 DT.95146246 DT.310353 DT.100746813 DT.99958597 DT.100774353 DT.120758443

24/281 AceView cDNA sequences (see all 281):

BM853932 AA236028 F03234 AL541223 CD370867 BG697811 BG548331 AA486828

BM856053 BI756378 BQ009315 BM841742 AI080408 AA890469 BU676020 AW512226

BQ049415 F01718 AI333340 BC033824 AW780348 AA278312 AA600285 AA856652

GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for NUMB (see all 16) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7a	·	7b	·	7c	^	8a	·	8b	^	9	^	10	^	11a	·	11b	·	11c	^	12a	·	12b	·	12c	^	13a	·	13b	·	13c	^
SP1:									-				-												-		-				-		-		-																-
SP2:									-				-												-		-				-		-		-																-
SP3:									-				-												-		-		-		-		-		-																-
SP4:									-				-												-		-		-		-		-		-																-
SP5:													-		-										-		-				-		-		-																-

ExUns:	14a	·	14b	·	14c	·	14d	^	15a	·	15b	^	16	^	17a	·	17b	·	17c	·	17d
SP1:											-
SP2:											-		-
SP3:											-
SP4:											-		-
SP5:											-		-

ECgene alternative splicing isoforms for NUMB

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NUMB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCAGAGATT

About this image
See NUMB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NUMB

SOURCE GeneReport for Unigene clusters: Hs.525443 Hs.654609 Hs.714879

SABiosciences Expression via Pathway-Focused PCR Arrays including NUMB:

Hedgehog Signaling Pathway in human mouse rat

Embryonic Stem Cells in human mouse rat

Notch Signaling Pathway in human mouse rat

Stem Cells in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUMB Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUMB

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUMB

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for NUMB gene from 6/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	NUMB¹	numb homolog (Drosophila)	77.82(n) 83.88(a)		395639 NM_204835.1 NP_990166.1
lizard (Anolis carolinensis)	Reptilia	NUMB⁶	--	81(a)	1 ↔ 1	1(39077910-39113028)
African clawed frog (Xenopus laevis)	Amphibia	BG364060.1²	--	73.47(n)		BG364060.1
zebrafish (Danio rerio)	Actinopterygii	numb¹	numb homolog (Drosophila)	64.99(n) 67.45(a)		692064 NM_001040406.1 NP_001035496.1
fruit fly (Drosophila melanogaster)	Insecta	numb³	N receptor signaling pathway protein binding	56(a)		30B5 --
worm (Caenorhabditis elegans)	Secernentea	num-1⁶	Numb-related protein 1	24(a)	1 → many	V(20829780-20837521)

ENSEMBL Gene Tree for NUMB (if available)
TreeFam Gene Tree for NUMB (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NUMB gene

NUMBL² GULP1² LDLRAP1²

1 SIMAP similar gene for NUMB using alignment to 11 protein entries: NUMB_HUMAN (see all proteins):

NUMBL

NUMB for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs10146755^1,2	C,H	--	53907087(+)	`GATTTT/AAAAAA`	4	--	ds500¹		4		NS EA	420
rs56270625^1,2	C,	--	53907174(+)	`ACCAGC/TTCCTA`	4	--	ds500¹		3		NA EA	242
rs74848346^1,2		--	53907381(+)	`AGGAAA/GGGGGA`	4	--	ds500¹		0	--	--	--	--
rs74061088^1,2	C,	--	53907409(+)	`GGCAAC/AAGCTT`	4	--	ut3¹		1		WA	2
rs74061089^1,2	C,F,	--	53908293(+)	`CTGGGA/GATTCT`	4	--	ut3¹		3		WA CSA	122
rs17126536^1,2	F	--	53908353(+)	`TCTTGA/CTCTCT`	4	--	ut3¹		3		NA	142
rs73306841^1,2	C,F,	--	53908677(+)	`GTGAAA/GAGAGT`	4	--	ut3¹		4		WA CSA	124
rs61746660^1,2	F	--	53909022(+)	`TGGTAC/GCACTG`	8	A G	mis¹		1		NS	48
rs1050479^1,2	H	--	53909463(-)	`TGGTGC/ATGCCT`	8	/D /A	mis¹ ese³		4		NS EA	406
rs34076521^1,2	C,F,	--	53909752(-)	`NNNNTG/ACCGTG`	4	--	int¹		5		WA CSA NA EA	362

HapMap Linkage Disequilibrium report for NUMB (73741815 - 73930348 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for NUMB
1 Indel: 101978
Human Gene Mutation Database (HGMD): NUMB

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NUMB

DNA2.0 Custom Variant and Variant Library Synthesis for NUMB

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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NUMB for disorders           About GeneDecksing

OMIM gene information: 603728    OMIM disorders: --

11 diseases for NUMB:    About MalaCards

early-onset familial alzheimer disease sensory peripheral neuropathy peripheral neuropathy neuropathy

alzheimer's disease breast cancer astrocytoma atherosclerosis

cervicitis neuronitis carcinoma

2 diseases from the University of Copenhagen DISEASES database for NUMB:

Tactile agnosia Lip disease

3 Novoseek disease relationships for NUMB gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer	5.13	1	16452208 (1)
tumors	4.74	5	15492044 (3), 17332928 (2)
cancer	0	1	17332928 (1)

Human Genome Epidemiology (HuGE) Navigator: NUMB (2 documents)

Export disorders for NUMB gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NUMB gene, integrated from 9 sources (see all 79):
(articles sorted by number of sources associating them with NUMB)

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Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module. (PubMed id 9303539)^{1, 2, 9} Salcini A.E....Di Fiore P.P. (1997)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
A novel transmembrane protein recruits numb to the plasma membrane during asymmetric cell division. (PubMed id 14670962)^{1, 2} Qin H.... Li S.S.-C. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis. (PubMed id 12775724)^{1, 2} Rosse C.... Camonis J. (2003)
Siah-1 binds and regulates the function of Numb. (PubMed id 11752454)^{1, 2} Susini L.... Telerman A. (2001)
Distinct human NUMB isoforms regulate differentiation vs. proliferation in the neuronal lineage. (PubMed id 10468633)^{1, 2} Verdi J.M.... Lipshitz H.D. (1999)
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. (PubMed id 7596406)^{1, 2} Sherrington R....Holman K. (1995)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8650	HGNC: 8060	AceView: NUMB	Ensembl:ENSG00000133961	euGenes: HUgn8650
ECgene: NUMB	Kegg: 8650	H-InvDB: NUMB

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for NUMB	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NUMB gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NUMB gene:
Search GeneIP for patents involving NUMB

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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NUMB Gene

numb homolog (Drosophila)

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NUMB Gene

numb homolog (Drosophila)

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