Aliases for NUMB Gene
External Ids for NUMB Gene
Previous Symbols for NUMB Gene
The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for NUMB Gene
NUMB (Numb Homolog (Drosophila)) is a Protein Coding gene. Diseases associated with NUMB include lip disease and tactile agnosia. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include beta-catenin binding and alpha-catenin binding. An important paralog of this gene is GULP1.
UniProtKB/Swiss-Prot for NUMB Gene
Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage