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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NUMB Gene

protein-coding   GIFtS: 68
GCID: GC14M073741

Numb Homolog (Drosophila)

(Previous names: numb (Drosophila) homolog, chromosome 14 open reading frame...)
(Previous symbol: C14orf41)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Numb Homolog (Drosophila)1 2     Numb (Drosophila) Homolog1
C14orf411 2     c14_55272
h-Numb2 3     Protein Numb Homolog2
S1712 5     Protein S1713
Chromosome 14 Open Reading Frame 411     

External Ids:    HGNC: 80601   Entrez Gene: 86502   Ensembl: ENSG000001339617   OMIM: 6037285   UniProtKB: P497573   

Export aliases for NUMB gene to outside databases

Previous GC identifers: GC14M071246 GC14M067537 GC14M071731 GC14M072811 GC14M053907


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NUMB Gene:
The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded
protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that
has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms
have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for NUMB Gene: 
NUMB (numb homolog (Drosophila)) is a protein-coding gene. Diseases associated with NUMB include lip disease, and sensory peripheral neuropathy, and among its related super-pathways are Notch signaling pathway and Constitutive Signaling by NOTCH1 PEST Domain Mutants. GO annotations related to this gene include alpha-catenin binding and beta-catenin binding. An important paralog of this gene is NUMBL.

UniProtKB/Swiss-Prot: NUMB_HUMAN, P49757
Function: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain
neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose
progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the
onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ
neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage

Gene Wiki entry for NUMB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NUMB gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNUMB promoter sequence
   Search SABiosciences Chromatin IP Primers for NUMB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUMB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q24.3

NUMB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUMB gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M073741:  view genomic region     (about GC identifiers)

Start:
73,741,815 bp from pter      End:
73,930,348 bp from pter
Size:
188,534 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NUMB_HUMAN, P49757 (See protein sequence)
Recommended Name: Protein numb homolog  
Size: 651 amino acids; 70804 Da
Subunit: Interacts with CDH1 and TFAP2B (By similarity). Interacts with EPS15, LNX and NOTCH1. May interact with
DUOXA1. Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis
Subcellular location: Membrane; Peripheral membrane protein
Sequence caution: Sequence=AAH20788.1; Type=Miscellaneous discrepancy; Note=Intron retention;
Secondary accessions: B4E2B1 Q6NUQ7 Q86SY1 Q8WW73 Q9UBG1 Q9UEQ4 Q9UKE8 Q9UKE9 Q9UKF0 Q9UQJ4
Alternative splicing: 4 isoforms:  P49757-1   P49757-2   P49757-3   P49757-4   

Explore the universe of human proteins at neXtProt for NUMB: NX_P49757

Explore proteomics data for NUMB at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on Ser-276 and Ser-295 by CaMK1 (By similarity)
  • UniProtKB: Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation (By
    similarity). Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P49757

  • NUMB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NUMB Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001005743.1  NP_001005744.1  NP_001005745.1  NP_003735.3  

    ENSEMBL proteins: 
     ENSP00000452416   ENSP00000348644   ENSP00000451117   ENSP00000451300   ENSP00000451513  
     ENSP00000451625   ENSP00000452888   ENSP00000453209   ENSP00000452069   ENSP00000450817  
     ENSP00000451326   ENSP00000452357   ENSP00000451374   ENSP00000451559   ENSP00000451959  
     ENSP00000347169   ENSP00000352563   ENSP00000394025   ENSP00000446001   ENSP00000441258  
    Reactome Protein details: P49757
    Human Recombinant Protein Products for NUMB: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for NUMB
    OriGene Protein Over-expression Lysate for NUMB
    OriGene MassSpec for NUMB 
    OriGene Custom Protein Services for NUMB
    GenScript Custom Purified and Recombinant Proteins Services for NUMB
    Novus Biologicals NUMB Proteins
    Novus Biologicals NUMB Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NUMB 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005769early endosome IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS7596406

    NUMB for ontologies           About GeneDecksing



    NUMB Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of NUMB
    R&D Systems Antibodies for NUMB
    Cell Signaling Technology (CST) Antibodies for NUMB 
    OriGene Antibodies for NUMB
    OriGene Custom Antibody Services for NUMB
    GenScript Superior Antibodies for NUMB
    Novus Biologicals NUMB Antibodies
    Abcam antibodies for NUMB
    Cloud-Clone Corp. Antibodies for NUMB 
    ThermoFisher Antibody for NUMB
    LSBio Antibodies in human, mouse, rat for NUMB 

    Assay Products for NUMB: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NUMB
    R&D Systems ELISAs for NUMB
    GenScript Custom Assay Services for NUMB
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NUMB 
    Cloud-Clone Corp. CLIAs for NUMB


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR011993 PH_like_dom
     IPR010449 Numb_domain
     IPR006020 PTyr_interaction_dom
     IPR016698 Numb/numb-like

    Graphical View of Domain Structure for InterPro Entry P49757

    ProtoNet protein and cluster: P49757

    2 Blocks protein domains:
    IPB006020 Phosphotyrosine interaction domain
    IPB010449 NUMB phenylalanine-rich


    UniProtKB/Swiss-Prot: NUMB_HUMAN, P49757
    Similarity: Contains 1 PID domain


    NUMB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NUMB_HUMAN, P49757
    Function: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain
    neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose
    progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the
    onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ
    neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage

         Genatlas biochemistry entry for NUMB:
    Drosophila numb homolog,signal transducer Eps15 of yeast,nematode homolog

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17203073
    GO:0008013beta-catenin binding IEA--
    GO:0045294alpha-catenin binding IEA--
    GO:0045296cadherin binding IEA--
         
    NUMB for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NUMB:
     Synthetic lethal with Ras 

         12 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Numb):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  growth/size 
     hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism  mortality/aging  nervous system 
     normal  reproductive system 

    NUMB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NUMB: Numbtm1.1Ynj Numbtm1.1Zili

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NUMB 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NUMB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NUMB 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NUMB 

    miRNA
    Products:
        
    miRTarBase miRNAs that target NUMB:
    hsa-mir-31 (MIRT004970)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NUMB
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate NUMB (see all 18):
    hsa-miR-429 hsa-miR-146a hsa-miR-1271 hsa-miR-219-5p hsa-miR-374a hsa-miR-410 hsa-miR-508-3p hsa-miR-3119
    SwitchGear 3'UTR luciferase reporter plasmidNUMB 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NUMB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUMB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NUMB
    Sirion Biotech Customized adenovirus for overexpression of NUMB

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NUMB (see all 26)
    OriGene ORF clones in mouse, rat for NUMB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): NUMB (NM_003744)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUMB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUMB
    Sirion Biotech Customized lentivirus for stable overexpression of NUMB 
                         Customized lentivirus expression plasmids for stable overexpression of NUMB 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for NUMB
    Search LifeMap BioReagents cell lines for NUMB
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUMB


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NUMB About   (see all 12)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Notch signaling pathway
    Notch signaling pathway0.84
    Delta-Notch Signaling Pathway0.33
    Notch Signaling Pathway0.84
    2Signaling by NOTCH1 t(7 9)(NOTCH1:M1580 K2555) Translocation Mutant
    Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH1 in Cancer0.79
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH10.79
    FBXW7 Mutants and NOTCH1 in Cancer0.79
    Signaling by NOTCH1 t(7 9)(NOTCH1:M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH1 HD Domain Mutants in Cancer0.79
    Signaling by NOTCH0.74
    3Axon guidance
    Axon guidance0.69
    L1CAM interactions0.39
    Developmental Biology0.69
    Recycling pathway of L10.38
    4NOTCH2 intracellular domain regulates transcription
    Activated NOTCH1 Transmits Signal to the Nucleus0.59
    5Signaling by GPCR
    Signal Transduction0.55

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for NUMB
        Notch Signaling Pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for NUMB
        Molecular Mechanisms of Cancer

    2 Cell Signaling Technology (CST) Pathways for NUMB
        Wnt / Hedgehog / Notch
    Neuroscience

    4 BioSystems Pathways for NUMB
        Notch Signaling Pathway
    Delta-Notch Signaling Pathway
    Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
    Notch signaling pathway

    5/15        Reactome Pathways for NUMB (see all 15)
        L1CAM interactions
    Signaling by NOTCH
    Developmental Biology
    FBXW7 Mutants and NOTCH1 in Cancer
    Signaling by NOTCH1 HD Domain Mutants in Cancer


    1         Kegg Pathway  (Kegg details for NUMB):
        Notch signaling pathway


    NUMB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NUMB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/44 Interacting proteins for NUMB (P497572, 3 ENSP000003471694) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKCZQ055132, 3, ENSP000003678304MINT-4298232 MINT-4298218 MINT-4298249 MINT-4298283 I2D: score=1 STRING: ENSP00000367830
    EPS15P425662, 3, ENSP000003607984MINT-17946 MINT-17947 I2D: score=5 STRING: ENSP00000360798
    AP2A1O957822, 3, ENSP000003519264MINT-4298264 I2D: score=2 STRING: ENSP00000351926
    EGFRP005332, 3, ENSP000002754934MINT-74593 I2D: score=2 STRING: ENSP00000275493
    LNX1Q8TBB13, ENSP000002639254I2D: score=5 STRING: ENSP00000263925
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007219Notch signaling pathway TAS--
    GO:0007399nervous system development ----
    GO:0007405neuroblast proliferation ----
    GO:0007409axonogenesis ----
    GO:0007411axon guidance TAS--

    NUMB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NUMB

    Search CenterWatch for drugs/clinical trials and news about NUMB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NUMB gene (4 alternative transcripts): 
    NM_001005743.1  NM_001005744.1  NM_001005745.1  NM_003744.5  

    Unigene Clusters for NUMB:

    Numb homolog (Drosophila)
    Hs.525443  [show with all ESTs], Hs.654609  [show with all ESTs], Hs.714879
    Unigene Representative Sequences: AK055876, AK226069, AK294591
    18/33 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 33):
    ENST00000554546(uc010ttz.1 uc010arp.1 uc010arr.1 uc001xoa.1 uc001xob.1)
    ENST00000356296(uc001xod.1) ENST00000557597 ENST00000555238(uc010aro.1 uc010arq.1 uc001xny.1 uc001xnz.1 uc001xoc.1 uc010ars.1)
    ENST00000556772 ENST00000555394(uc001xof.1 uc001xog.3) ENST00000559312
    ENST00000560335 ENST00000555738 ENST00000554521 ENST00000554014 ENST00000553997
    ENST00000557486 ENST00000555859 ENST00000555307 ENST00000554394 ENST00000554315(uc001xoh.1)
    ENST00000556989

    miRNA
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    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate NUMB (see all 18):
    hsa-miR-429 hsa-miR-146a hsa-miR-1271 hsa-miR-219-5p hsa-miR-374a hsa-miR-410 hsa-miR-508-3p hsa-miR-3119
    SwitchGear 3'UTR luciferase reporter plasmidNUMB 3' UTR sequence
    Inhib. RNA
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    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUMB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUMB
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUMB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUMB

    Additional mRNA sequence: AK294591.1 

    24/35 DOTS entries (see all 35):

    DT.417960  DT.100828613  DT.95261004  DT.95261062  DT.95261159  DT.40125317  DT.101958534  DT.95122429 
    DT.95261058  DT.101984283  DT.40107298  DT.75105596  DT.120758323  DT.310351  DT.100828610  DT.100828614 
    DT.120758409  DT.100035916  DT.95146246  DT.310353  DT.100746813  DT.99958597  DT.100774353  DT.120758443 

    24/281 AceView cDNA sequences (see all 281):

    AA336300 AI890090 BM769879 BM823609 Z38627 F05457 AW008797 Z44006 
    AA487149 AA825182 BP363865 BQ189373 AA513444 CD365680 AI921872 BE673258 
    AA418445 BG110839 BX390808 CR600039 N68734 BX342338 BE882223 BE672190 

    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for NUMB (see all 16)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13a · 13b · 13c ^
    SP1:                          -           -                                   -     -           -     -     -                                               -   
    SP2:                          -           -                                   -     -           -     -     -                                               -   
    SP3:                          -           -                                   -     -     -     -     -     -                                               -   
    SP4:                          -           -                                   -     -     -     -     -     -                                               -   
    SP5:                                      -     -                             -     -           -     -     -                                               -   

    ExUns: 14a · 14b · 14c · 14d ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c · 17d
    SP1:                                -                                 
    SP2:                                -     -                           
    SP3:                                -                                 
    SP4:                                -     -                           
    SP5:                                -     -                           


    ECgene alternative splicing isoforms for NUMB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NUMB expression in normal human tissues (normalized intensities)      NUMB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCAGAGATT
    NUMB Expression
    About this image


    NUMB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 16 entries
             Thalamus
             Septum   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             neutrophils   
     
     Heart (Cardiovascular System)
             heart/ventricle   
     
     Spinal Cord (Nervous System)
             Ventral Horn   

    See NUMB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NUMB

    SOURCE GeneReport for Unigene clusters: Hs.525443 Hs.654609 Hs.714879
        SABiosciences Expression via Pathway-Focused PCR Arrays including NUMB: 
              Hedgehog Signaling Pathway in human mouse rat
              Embryonic Stem Cells in human mouse rat
              Notch Signaling Pathway in human mouse rat
              Stem Cells in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NUMB gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Numb1 , 5 numb gene homolog (Drosophila)1, 5 89.55(n)1
    93.7(a)1
      12 (38.89 cM)5
    182221  NM_001136075.11  NP_001129547.11 
     837940345 
    chicken
    (Gallus gallus)
    Aves NUMB1 numb homolog (Drosophila) 77.82(n)
    83.88(a)
      395639  NM_204835.1  NP_990166.1 
    lizard
    (Anolis carolinensis)
    Reptilia NUMB6
    Uncharacterized protein
    82(a)
    1 ↔ 1
    1(39077910-39113045)
    African clawed frog
    (Xenopus laevis)
    Amphibia BG364060.12   -- 73.47(n)    BG364060.1 
    zebrafish
    (Danio rerio)
    Actinopterygii numb1 numb homolog (Drosophila) 64.99(n)
    67.45(a)
      692064  NM_001040406.1  NP_001035496.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta numb3 N receptor signaling pathway protein
    binding
    56(a)   30B5   --
    worm
    (Caenorhabditis elegans)
    Secernentea num-16
    Numb-related protein 1
    23(a)
    1 → many
    V(20829811-20837552)


    ENSEMBL Gene Tree for NUMB (if available)
    TreeFam Gene Tree for NUMB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NUMB gene
    NUMBL2  LDLRAP12  GULP12  
    1 SIMAP similar gene for NUMB using alignment to 11 protein entries:     NUMB_HUMAN (see all proteins):
    NUMBL

    NUMB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3824 SNPs in NUMB are shown (see all 3824)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1124943111,2
    C,F--53927065(+) TGGGAG/CGCCGA 4 -- int12Minor allele frequency- C:0.50NA 4
    rs128806931,2
    C,F--53927068(+) GACGCT/CGAGGT 4 -- int14Minor allele frequency- C:0.30NA 10
    rs2007857601,2
    --53987049(+) ACAGG-/CCAGGC 4 -- int10--------
    rs2000482441,2
    C--53987062(+) GGTGGC/TTCAGG 4 -- int10--------
    rs2006590171,2
    C--53987065(+) GGCTCA/CGGCCT 4 -- int10--------
    rs1113818201,2
    C--54018364(+) GCTTTTTTG/-  
            
    TTTTG
    4 -- int11Minor allele frequency- -:0.50CSA 2
    rs361361681,2
    C--54018368(+) TTTTG-/CTT   
      G
    /GTTT
    TTTGT
    4 -- int10--------
    rs58096131,2
    C--54048791(+) TGCTT-/G/GCTT
            
    CTCAT
    4 -- int11NA 2
    rs2013492111,2
    --54048906(+) AACAA-/CATTGTTA 4 -- int10--------
    rs1120549381,2
    F--54069986(+) ATTTTC/TAGTAA 4 -- int11Minor allele frequency- T:0.50CSA 2

    HapMap Linkage Disequilibrium report for NUMB (73741815 - 73930348 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for NUMB:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2671759CNV Deletion23128226
    esv2659371CNV Deletion23128226
    esv1057343CNV Insertion17803354
    nsv513412CNV Insertion21212237
    nsv513411CNV Insertion21212237
    esv2651254CNV Insertion19546169
    nsv902085CNV Gain21882294
    dgv1958n71CNV Gain21882294
    nsv826974CNV Gain20364138


    Human Gene Mutation Database (HGMD): NUMB
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603728    OMIM disorders: --

    16 diseases for NUMB:    About MalaCards
    lip disease    sensory peripheral neuropathy    agnosia    peripheral neuropathy
    neuropathy    myelodysplastic syndromes    alzheimer's disease    astrocytoma
    atherosclerosis    acute myeloid leukemia    myeloid leukemia    cervicitis
    colon cancer    breast cancer    leukemia    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for NUMB:
    Tactile agnosia     Lip disease

    NUMB for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    3 Novoseek inferred disease relationships for NUMB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 5.13 1 16452208 (1)
    tumors 4.74 5 15492044 (3), 17332928 (2)
    cancer 0 1 17332928 (1)

    Genetic Association Database (GAD): NUMB
    Human Genome Epidemiology (HuGE) Navigator: NUMB (2 documents)

    Export disorders for NUMB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NUMB gene, integrated from 9 sources (see all 89):
    (articles sorted by number of sources associating them with NUMB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module. (PubMed id 9303539)1, 2, 9 Salcini A.E....Di Fiore P.P. (1997)
    2. Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study. (PubMed id 17903303)1, 4 O'Donnell C.J....Demissie S. (2007)
    3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. A novel transmembrane protein recruits numb to the plasma membrane during asymmetric cell division. (PubMed id 14670962)1, 2 Qin H.... Li S.S.-C. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis. (PubMed id 12775724)1, 2 Rosse C.... Camonis J. (2003)
    9. Siah-1 binds and regulates the function of Numb. (PubMed id 11752454)1, 2 Susini L.... Telerman A. (2001)
    10. Distinct human NUMB isoforms regulate differentiation vs. proliferation in the neuronal lineage. (PubMed id 10468633)1, 2 Verdi J.M.... Lipshitz H.D. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8650 HGNC: 8060 AceView: NUMB Ensembl:ENSG00000133961 euGenes: HUgn8650
    ECgene: NUMB Kegg: 8650 H-InvDB: NUMB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NUMB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NUMB Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NUMB gene:
    Search GeneIP for patents involving NUMB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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