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NUMA1 Gene

protein-coding   GIFtS: 64
GCID: GC11M071713

Nuclear Mitotic Apparatus Protein 1

  See NUMA1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Nuclear Mitotic Apparatus Protein 11 2
NUMA2 3
SP-H Antigen2 3
Centrophilin Stabilizes Mitotic Spindle In Mitotic Cells2
Structural Nuclear Protein2
NuMA Protein3

External Ids:    HGNC: 80591   Entrez Gene: 49262   Ensembl: ENSG000001374977   OMIM: 1640095   UniProtKB: Q149803   
ORGUL members:         

Export aliases for NUMA1 gene to outside databases

Previous GC identifers: GC11M074046 GC11M073253 GC11M071936 GC11M071440 GC11M071391 GC11M068007


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NUMA1 Gene:
This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein
interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell
division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome
17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple
transcript variants. (provided by RefSeq, Nov 2013)

GeneCards Summary for NUMA1 Gene:
NUMA1 (nuclear mitotic apparatus protein 1) is a protein-coding gene. Diseases associated with NUMA1 include leukemia, acute promyelocytic, numa/rara type, and acute promyelocytic leukemia. GO annotations related to this gene include structural molecule activity.

UniProtKB/Swiss-Prot: NUMA1_HUMAN, Q14980
Function: Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role,
occupies the majority if the nuclear volume. Required for maintenance and establishment of the mitotic spindle
poles, functionning as a tether linking bulk microtubules of the spindle to centrosomes. May be involved in
coordination of the alignment of the mitotic spindle to the cellular polarity axis, which is a prerequisite for
asymmetric cell divisions

Gene Wiki entry for NUMA1 (Nuclear mitotic apparatus protein 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NUMA1 gene promoter:
         SRF   Sox5   SRF (504 AA)   FOXD1   CUTL1   Nkx2-5   GATA-2   HEN1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NUMA1 promoter sequence
   Search Chromatin IP Primers for NUMA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NUMA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q13

NUMA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUMA1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M071713:  view genomic region     (about GC identifiers)

Start:
71,713,910 bp from pter      End:
71,791,739 bp from pter
Size:
77,830 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NUMA1_HUMAN, Q14980 (See protein sequence)
Recommended Name: Nuclear mitotic apparatus protein 1  
Size: 2115 amino acids; 238260 Da
Subunit: Homodimer. Also forms multiarm oligomers by association of C-terminal tail domains, oligomers may further
assemble to form a hexagonal nuclear lattice-like network. Interacts with TNKS
Sequence caution: Sequence=CAA77670.1; Type=Frameshift; Positions=1270, 1299;
1 PDB 3D structure from and Proteopedia for NUMA1:
3RO2 (3D)    
Secondary accessions: H0YH75 Q14981
Alternative splicing: 4 isoforms:  Q14980-1   Q14980-2   Q14980-3   Q14980-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NUMA1: NX_Q14980

Explore proteomics data for NUMA1 at MOPED

Post-translational modifications: 

  • ADP-ribosylated by TNKS during mitosis1
  • Phosphorylated in the C-terminal tail during mitosis, probably by CDK1. Phosphorylation increases solubility and
    promotes association with dynein and subsequent translocation to the spindle poles1
  • O-glycosylated during cytokinesis at sites identical or close to phosphorylation sites, this interferes with the
    phosphorylation status1
  • Ubiquitination2 at Lys54, Lys326, Lys358, Lys364, Lys386, Lys604, Lys616, Lys855, Lys891, Lys908,
                                 Lys1330, Lys1335, Lys1430, Lys1475, Lys1511, Lys1573, Lys1699, Lys1708, Lys1766, Lys1821
  • Glycosylation2 at Ser1844
  • Modification sites at PhosphoSitePlus

  • See NUMA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001273490.1  NP_006176.2  

    ENSEMBL proteins: 
     ENSP00000440954   ENSP00000260051   ENSP00000351851   ENSP00000377298   ENSP00000446396  
     ENSP00000444880   ENSP00000442936   ENSP00000442761   ENSP00000439759   ENSP00000438821  
     ENSP00000438589   ENSP00000439092   ENSP00000444175   ENSP00000439576   ENSP00000357955  
     ENSP00000438331   ENSP00000438318   ENSP00000441598   ENSP00000441674   ENSP00000444831  
     ENSP00000442331  
    Reactome Protein details: Q14980

    NUMA1 Human Recombinant Protein Products:

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    Novus Biologicals NUMA1 Protein
    Novus Biologicals NUMA1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NUMA1

     
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    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for NUMA1
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    NUMA1 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026650 NUMA1

    Graphical View of Domain Structure for InterPro Entry Q14980

    ProtoNet protein and cluster: Q14980

    UniProtKB/Swiss-Prot: NUMA1_HUMAN, Q14980
    Domain: The C-terminal tubulin-binding domain mediates direct binding to microtubules, independantly of dynein and
    dynactin, and induces their bundling and stabilization


    Find genes that share domains with NUMA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NUMA1_HUMAN, Q14980
    Function: Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role,
    occupies the majority if the nuclear volume. Required for maintenance and establishment of the mitotic spindle
    poles, functionning as a tether linking bulk microtubules of the spindle to centrosomes. May be involved in
    coordination of the alignment of the mitotic spindle to the cellular polarity axis, which is a prerequisite for
    asymmetric cell divisions

         Genatlas biochemistry entry for NUMA1:
    nuclear mitotic apparatus protein

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0005198structural molecule activity TAS1541630
    GO:0005515protein binding IPI15537540
    GO:0008017microtubule binding IEA--
         
    Find genes that share ontologies with NUMA1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NUMA1:
     Increased gamma-H2AX phosphory 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Numa1):
     behavior/neurological  cellular  mortality/aging  nervous system 

    Find genes that share phenotypes with NUMA1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Numa1tm1.2Dwc for NUMA1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NUMA1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NUMA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NUMA1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NUMA1

    miRNA
    Products:
        
    miRTarBase miRNAs that target NUMA1:
    hsa-mir-335-5p (MIRT018163)

    Block miRNA regulation of human, mouse, rat NUMA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NUMA1 (see all 25):
    hsa-miR-148b hsa-miR-938 hsa-miR-605 hsa-miR-1260b hsa-miR-520a-5p hsa-miR-124 hsa-miR-661 hsa-miR-548x
    SwitchGear 3'UTR luciferase reporter plasmidNUMA1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NUMA1
    Predesigned siRNA for gene silencing in human, mouse, rat NUMA1

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: NUMA1 (NM_006185)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUMA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUMA1
    Addgene plasmids for NUMA1 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUMA1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NUMA1_HUMAN, Q14980: Nucleus matrix. Chromosome. Cytoplasm, cytoskeleton, spindle pole. Note=Resides in the
    nuclear matrix during interphases. Dissociates from condensing chromosomes during early prophase, and relocates
    to the spindle poles via dynein/dynamin association, it remain there until the anaphase onset. Before the
    complete disintegration of the nuclear lamina. As mitosis progresses it reassociates with telophase chromosomes
    very early during nuclear reformation, before substantial accumulation of lamins on chromosomal surfaces is
    evident
    NUMA1_HUMAN, Q14980: Isoform Numa-m: Cytoplasm. Note=Mainly clustered at the centrosomal region
    NUMA1_HUMAN, Q14980: Isoform Numa-s: Cytoplasm. Note=Mainly clustered at the centrosomal region
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol4
    mitochondrion2
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane ----
    GO:0000922spindle pole IDA14718566
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005694chromosome IEA--

    Find genes that share ontologies with NUMA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NUMA1 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Apoptosis and survival Caspase cascade
    Apoptosis and survival Caspase cascade0.44
    Caspase cascade in apoptosis0.42
    Apoptosis and survival FAS signaling cascades0.44
    2Regulation of PLK1 Activity at G2/M Transition
    Recruitment of mitotic centrosome proteins and complexes0.86
    Mitotic G2-G2/M phases0.69
    Centrosome maturation0.86
    Recruitment of NuMA to mitotic centrosomes0.00
    G2/M Transition0.70
    3Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90
    4Granzyme Pathway
    Granzyme Pathway
    Granzyme-B Pathway0.00
    5Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32


    Find genes that share SuperPaths with NUMA1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NUMA1
        Granzyme-B Pathway
    Granzyme Pathway

    1 Cell Signaling Technology (CST) Pathway for NUMA1
        Cell Cycle / Checkpoint Control

    3 GeneGo (Thomson Reuters) Pathways for NUMA1
        Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades
    Cell cycle Spindle assembly and chromosome separation

    1 BioSystems Pathway for NUMA1
        Caspase cascade in apoptosis

    1 Reactome Pathway for NUMA1
        Recruitment of NuMA to mitotic centrosomes


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NUMA1
    Interactions:

        GeneGlobe Interaction Network for NUMA1

    Selected Interacting proteins for NUMA1 (Q149801, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GPSM2P812741, 3EBI-521611,EBI-618655 I2D: score=4 
    GNAI1P630961, 3EBI-521611,EBI-618639 I2D: score=3 
    HSP90AB1P082382, 3MINT-72664 I2D: score=3 
    YWHAZP631042, 3MINT-3295089 I2D: score=1 
    EPB41P111713I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000090mitotic anaphase TAS1541636
    GO:0000132establishment of mitotic spindle orientation IEA--
    GO:0000278mitotic cell cycle TAS--
    GO:0006997nucleus organization TAS1541630

    Find genes that share ontologies with NUMA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NUMA1

    6 Novoseek inferred chemical compound relationships for NUMA1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nocodazole 46.3 2 1679010 (1), 12477396 (1)
    retinoic acid 40.7 3 9288109 (2), 10360373 (1)
    paclitaxel 16.7 1 11781568 (1)
    nacl 0 1 1679010 (1)
    atp 0 1 1679010 (1)
    threonine 0 1 7769006 (1)



    Find genes that share compounds with NUMA1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NUMA1 gene (2 alternative transcripts): 
    NM_001286561.1  NM_006185.3  

    Unigene Cluster for NUMA1:

    Nuclear mitotic apparatus protein 1
    Hs.325978  [show with all ESTs]
    Unigene Representative Sequence: Z11584
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 31):
    ENST00000540626(uc001orj.2) ENST00000541584 ENST00000351960(uc001ork.1)
    ENST00000358965(uc009ysw.1 uc009ysx.1 uc001oro.1 uc001orm.1)
    ENST00000393695(uc001orn.2 uc001orl.1) ENST00000541262 ENST00000545721
    ENST00000546036 ENST00000540588 ENST00000542977 ENST00000537217 ENST00000534987(uc001orp.3)
    ENST00000540843(uc009ysy.2 uc001orq.3) ENST00000536119 ENST00000544238
    ENST00000543937(uc021qmw.1) ENST00000543009 ENST00000537930
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NUMA1 (see all 25):
    hsa-miR-148b hsa-miR-938 hsa-miR-605 hsa-miR-1260b hsa-miR-520a-5p hsa-miR-124 hsa-miR-661 hsa-miR-548x
    SwitchGear 3'UTR luciferase reporter plasmidNUMA1 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat NUMA1

    Additional mRNA sequence: 

    AB208841.1 AB210007.1 AB621824.1 AK290509.1 AK307577.1 AK309041.1 BC004165.2 BC008345.1 
    BC013023.2 BC027493.1 BC032228.1 BC036808.1 BC043499.1 BC068539.1 BC103765.1 BC126909.1 
    Z11583.1 Z11584.1 Z14227.1 Z14228.1 Z14229.1 

    Selected DOTS entries (see all 36):

    DT.100881038  DT.100881042  DT.448720  DT.95201570  DT.40132911  DT.95201565  DT.120712074  DT.91715291 
    DT.95090721  DT.95103148  DT.100034579  DT.92324397  DT.95324983  DT.120712033  DT.120712043  DT.91713375 
    DT.100881034  DT.75120030  DT.95137931  DT.40305758  DT.120711938  DT.120712069  DT.120711924  DT.100045744 

    Selected AceView cDNA sequences (see all 824):

    BQ921623 BI333698 CA393711 BU157442 BC036808 BU526485 BE264135 BU161239 
    BU537945 BQ678640 BE242409 BX378686 BP358621 BF725399 AA323592 BM804999 
    BQ937342 BG470017 BU173264 BM700180 BE379090 BE894353 BF725649 BP356745 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NUMA1 (see all 16)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11 ^ 12a · 12b · 12c ^
    SP1:                                      -     -     -     -           -     -     -     -     -                 -                 -                       -   
    SP2:                                -     -     -     -     -           -     -     -     -     -                 -                 -                       -   
    SP3:                                                                          -     -     -     -                 -                 -                       -   
    SP4:                                                                    -     -     -     -     -                 -                 -                           
    SP5:                                -     -     -     -     -           -     -           -     -                 -                                             

    ExUns: 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27a · 27b · 27c ^ 28a · 28b
    SP1:                                            -                                                                                                         
    SP2:                                                                                                                                                      
    SP3:                                                                                                                                                      
    SP4:                                                                                                                                                      
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for NUMA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    NUMA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACAGTGTGG
    NUMA1 Expression
    About this image


    NUMA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 23) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Eye (Sensory Organs)
             Retina
    NUMA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NUMA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.325978
        Custom PCR Arrays for NUMA1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for NUMA1
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUMA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NUMA1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Numa11 , 5 nuclear mitotic apparatus protein 11, 5 83.33(n)1
    82.97(a)1
      7 (54.70 cM)5
    1017061  NM_133947.31  NP_598708.31 
     1019698435 
    chicken
    (Gallus gallus)
    Aves NUMA11 nuclear mitotic apparatus protein 1 64.68(n)
    56.89(a)
      768717  NM_001190925.1  NP_001177854.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    52(a)
    50(a)
    many → 1
    many → 1
    GL343792.1(150888-166011)
    GL343792.1(125536-149798)
    African clawed frog
    (Xenopus laevis)
    Amphibia NuMA2 nuclear/mitotic apparatus protein 74.13(n)    Y07624.1 
    zebrafish
    (Danio rerio)
    Actinopterygii NUMA1 (4 of 4)6
    NUMA1 (3 of 4)6
    (see all 4)
    nuclear mitotic apparatus protein 1
    (see all 4)
    35(a)
    32(a)
    (see all 4)
    many → 1
    many → 1
    (see all 4)
    15(42809392-42814574) ENSDARG00000088910
    15(42614952-42623009) ENSDARG00000087136


    ENSEMBL Gene Tree for NUMA1 (if available)
    TreeFam Gene Tree for NUMA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NUMA1 gene
    3 SIMAP similar genes for NUMA1 using alignment to 22 protein entries:     NUMA1_HUMAN (see all proteins):
    NuMA    NUMA1 variant protein    IFT81

    Find genes that share paralogs with NUMA1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NUMA1 (see all 1622)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs9493241,2
    C,F,A--71714526(-) CTGACG/CTCACC 1 -- ut31 ese315Minor allele frequency- C:0.09NA EU EA WA CSA 2855
    rs9493231,2
    C,F,A,H--71714528(-) TGCTGA/CCCTCA 1 -- ut31 ese330Minor allele frequency- T:0.00NA NS EA EU WA CSA 8948
    rs1995095691,2
    C--71714552(+) TGGGGA/CCACTC 1 -- ut310--------
    rs1927027831,2
    C--71714557(+) CCACTC/GACTGG 1 -- ut310--------
    rs1488256531,2
    C--71714559(+) ACTCAC/GTGGTA 1 -- ut310--------
    rs1838256161,2
    C--71714627(+) GCGATA/TCTAGC 1 -- int10--------
    rs2001526421,2
    --71714632(+) ACTAGC/TCTGCA 1 -- int10--------
    rs745468341,2
    C,F--71714654(+) GGAAGA/TTCTCT 1 -- int11Minor allele frequency- T:0.03EA 120
    rs57436811,2
    C,F,H--71714688(+) GATCCC/TCTCCC 1 -- int1 trp38Minor allele frequency- T:0.03NA EU NS EA WA 618
    rs57436831,2
    C,F,H--71714742(+) CTCTGG/AGTGCT 1 -- int110Minor allele frequency- A:0.04NA EU NS EA WA 634

    HapMap Linkage Disequilibrium report for NUMA1 (71713910 - 71791739 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for NUMA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2494956CNV Deletion19546169
    nsv384CNV Insertion18451855
    nsv428262CNV Gain+Loss18775914

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NUMA1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 164009    OMIM disorders: --

    2 diseases for NUMA1:    
    About MalaCards
    leukemia, acute promyelocytic, numa/rara type    acute promyelocytic leukemia


    Find genes that share disorders with NUMA1           About GenesLikeMe

    10 Novoseek inferred disease relationships for NUMA1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioma 12.1 1 11903063 (1)
    leukemia 1.6 1 9288109 (1)
    colon cancer 0.998 1 17575123 (1)
    necrosis 0 1 11455567 (1)
    shock 0 4 12944923 (1), 11453544 (1), 11449886 (1)
    inflammation 0 1 17397533 (1)
    breast cancer 0 7 15684076 (3), 12508117 (1), 11449886 (1), 10739661 (1)
    colorectal cancer 0 4 10470168 (4)
    tumors 0 1 10545425 (1)
    cancer 0 4 10629118 (1), 10470168 (1), 19804886 (1), 16146802 (1)

    Genetic Association Database (GAD): NUMA1
    Human Genome Epidemiology (HuGE) Navigator: NUMA1 (5 documents)

    Export disorders for NUMA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NUMA1 gene, integrated from 10 sources (see all 225):
    (articles sorted by number of sources associating them with NUMA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Primary structure and microtubule-interacting domain of the SP-H antigen: a mitotic map located at the spindle pole characterized as a homologous protein to NuMA. (PubMed id 8408288)1, 2, 9 Maekawa T. and Kuriyama R. (J. Cell Sci. 1993)
    2. Mutation of the predicted p34cdc2 phosphorylation sites in NuMA impair the assembly of the mitotic spindle and block mitosis. (PubMed id 7769006)1, 2, 9 Compton D.A. and Luo C. (J. Cell Sci. 1995)
    3. NuMA is a major acceptor of poly(ADP-ribosyl)ation by tankyrase 1 in mitosis. (PubMed id 16076287)1, 2, 9 Chang W.... Smith S. (Biochem. J. 2005)
    4. Direct binding of NuMA to tubulin is mediated by a novel sequence motif in the tail domain that bundles and stabilizes microtubules. (PubMed id 11956313)1, 2, 9 Haren L. and Merdes A. (J. Cell Sci. 2002)
    5. Nuclear mitotic apparatus protein (NuMA): spindle association, nuclear targeting and differential subcellular localization of various NuMA isoforms. (PubMed id 7962183)1, 2, 9 Tang T.K.... Wu C.W. (J. Cell Sci. 1994)
    6. NuMA: an unusually long coiled-coil related protein in the mammalian nucleus. (PubMed id 1541630)1, 2, 9 Yang C.H.... Snyder M. (J. Cell Biol. 1992)
    7. Primary structure of NuMA, an intranuclear protein that defines a novel pathway for segregation of proteins at mitosis. (PubMed id 1541636)1, 2, 9 Compton D.A.... Cleveland D.W. (J. Cell Biol. 1992)
    8. Assignment of the nuclear mitotic apparatus protein NuMA gene to human chromosome 11q13. (PubMed id 8406455)1, 3, 9 Sparks C.A....Fey E.G. (Genomics 1993)
    9. Nuclear proteins of the bovine esophageal epithelium. II. The NuMA gene gives rise to multiple mRNAs and gene products reactive with monoclonal antibody W1. (PubMed id 8505359)1, 2, 9 Tang T.K.... Wu C.W. (J. Cell Sci. 1993)
    10. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4926 HGNC: 8059 AceView: NUMA1 Ensembl:ENSG00000137497 euGenes: HUgn4926
    ECgene: NUMA1 H-InvDB: NUMA1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NUMA1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NUMA1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NUMA1 gene:
    Search GeneIP for patents involving NUMA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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