NUMA1 Gene
protein-coding GIFtS: 59
GCID: GC11M071713
|
|
nuclear mitotic apparatus protein 1
| |
Aliases
for NUMA1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nuclear Mitotic Apparatus Protein 11 2 | | NUMA2 3 | | SP-H Antigen2 3 | | Centrophilin Stabilizes Mitotic Spindle In Mitotic Cells2 | | Structural Nuclear Protein2 | | NuMA Protein3 |
Export aliases for NUMA1 gene to outside databasesPrevious GC identifers: GC11M074046 GC11M073253 GC11M071936 GC11M071440 GC11M071391 GC11M068007 |
Summaries
for NUMA1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: NUMA1_HUMAN, Q14980Function: Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupiesthe majority if the nuclear volume. Required for maintenance and establishment of the mitotic spindle poles,functionning as a tether linking bulk microtubules of the spindle to centrosomes. May be involved in coordination ofthe alignment of the mitotic spindle to the cellular polarity axis, which is a prerequisite for asymmetric celldivisions
Gene Wiki entry for NUMA1 (Nuclear mitotic apparatus protein 1)
|
Genomic Views
for NUMA1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NUMA1 gene promoter:
SRF Sox5 SRF (504 AA) FOXD1 CUTL1 Nkx2-5 GATA-2 HEN1 STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for NUMA1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUMA1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.4 HGNC cytogenetic band: 11q13NUMA1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M071713: view genomic region
(about GC identifiers)
Start:
|
71,713,910 bp from pter |
End:
|
71,791,739 bp from pter |
Size:
|
77,830 bases |
Orientation:
|
minus strand |
|
Proteins
for NUMA1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NUMA1_HUMAN, Q14980 (See
protein sequence)Recommended Name: Nuclear mitotic apparatus protein 1 Size: 2115 amino acids; 238260 Da
Subunit: Homodimer. Also forms multiarm oligomers by association of C-terminal tail domains, oligomers may furtherassemble to form a hexagonal nuclear lattice-like network. Interacts with TNKS
Subcellular location: Nucleus matrix. Chromosome. Cytoplasm, cytoskeleton, spindle pole. Note=Resides in the nuclearmatrix during interphases. Dissociates from condensing chromosomes during early prophase, and relocates to the spindlepoles via dynein/dynamin association, it remain there until the anaphase onset. Before the complete disintegration ofthe nuclear lamina. As mitosis progresses it reassociates with telophase chromosomes very early during nuclearreformation, before substantial accumulation of lamins on chromosomal surfaces is evident
Subcellular location: Isoform Numa-m: Cytoplasm. Note=Mainly clustered at the centrosomal region
Subcellular location: Isoform Numa-s: Cytoplasm. Note=Mainly clustered at the centrosomal region
Sequence caution: Sequence=CAA77670.1; Type=Frameshift; Positions=1270, 1299;
1 PDB 3D structure from  and Proteopedia  for NUMA1:3RO2 (3D)
Secondary accessions: H0YH75 Q14981Alternative splicing: 4 isoforms: Q14980-1 Q14980-2 Q14980-3 Q14980-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for NUMA1: NX_Q14980
Post-translational modifications:
ADP-ribosylated by TNKS during mitosis1
Phosphorylated in the C-terminal tail during mitosis, probably by CDK1. Phosphorylation increases solubility andpromotes association with dynein and subsequent translocation to the spindle poles1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q14980
NUMA1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006176.2
ENSEMBL proteins: ENSP00000440954 ENSP00000260051 ENSP00000351851 ENSP00000377298 ENSP00000446396 ENSP00000444880 ENSP00000442936 ENSP00000442761 ENSP00000439759 ENSP00000438821 ENSP00000438589 ENSP00000439092 ENSP00000444175 ENSP00000439576 ENSP00000357955 ENSP00000438331 ENSP00000438318 ENSP00000441598 ENSP00000441674 ENSP00000444831 ENSP00000442331 Reactome Protein details: Q14980
Human Recombinant Protein Products:
Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11): About this table
NUMA1 for ontologies About GeneDecksing
NUMA1 Antibody Products:
Assay Products for NUMA1: |
Protein
Domains /
Families
for NUMA1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q14980 UniProtKB/Swiss-Prot: NUMA1_HUMAN, Q14980Domain: The C-terminal tubulin-binding domain mediates direct binding to microtubules, independantly of dynein anddynactin, and induces their bundling and stabilization |
Function
for NUMA1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NUMA1_HUMAN, Q14980Function: Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupiesthe majority if the nuclear volume. Required for maintenance and establishment of the mitotic spindle poles,functionning as a tether linking bulk microtubules of the spindle to centrosomes. May be involved in coordination ofthe alignment of the mitotic spindle to the cellular polarity axis, which is a prerequisite for asymmetric celldivisions Genatlas biochemistry entry for NUMA1:nuclear mitotic apparatus protein
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUMA1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUMA1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NUMA1 (NM_006185) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NUMA1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUMA1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUMA1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
NUMA1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for NUMA1:
Animal Models:
Mouse knock-out Numa1tm1.2Dwc for NUMA1
4 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Numa1):
NUMA1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for NUMA1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Apoptosis and survival_Caspase cascade | | | 2 | Recruitment of mitotic centrosome proteins and complexes | | | 3 | Cell cycle_Spindle assembly and chromosome separation | | | 4 | Cell Cycle | | | 5 | Granzyme Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 EMD Millipore Pathways for NUMA1
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NUMA1
1 
Cell Signaling Technology (CST) Pathway for NUMA1
3  GeneGo (Thomson Reuters) Pathways for NUMA1
1  BioSystems Pathway for NUMA1
5/7 
Reactome Pathways for NUMA1 (see all 7)
NUMA1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NUMA1
5/28 Interacting proteins for NUMA1 (Q149801, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 28)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
NUMA1 for ontologies About GeneDecksing
|
Drugs & Compounds
for NUMA1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
NUMA1 for compounds About GeneDecksing
 Browse Tocris compounds for NUMA1
6 Novoseek chemical compound relationships for NUMA1 gene About this table
Search CenterWatch for drugs/clinical trials and news about NUMA1
|
Transcripts
for NUMA1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NUMA1 gene: NM_006185.2 Unigene Cluster for NUMA1: Nuclear mitotic apparatus protein 1 Hs.325978 [show with all ESTs]Unigene Representative Sequence: Z1158418/31 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 31): ENST00000540626(uc001orj.2) ENST00000541584 ENST00000351960(uc001ork.1)
ENST00000358965(uc009ysw.1 uc009ysx.1 uc001oro.1 uc001orm.1)
ENST00000393695(uc001orn.2 uc001orl.1) ENST00000541262 ENST00000545721
ENST00000546036 ENST00000540588 ENST00000542977 ENST00000537217 ENST00000534987(uc001orp.3)
ENST00000540843(uc009ysy.2 uc001orq.3) ENST00000536119 ENST00000544238
ENST00000543937(uc021qmw.1) ENST00000543009 ENST00000537930
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUMA1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUMA1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NUMA1 (NM_006185) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NUMA1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUMA1 |
Additional cDNA sequence: AB208841.1 AB210007.1 AB621824.1 AK290509.1 AK307577.1 AK309041.1 BC004165.2 BC008345.1 BC013023.2 BC027493.1 BC032228.1 BC036808.1 BC043499.1 BC068539.1 BC103765.1 BC126909.1 Z11583.1 Z11584.1 Z14227.1 Z14228.1 Z14229.1 24/36 DOTS entries (see all 36): DT.100881038 DT.100881042 DT.448720 DT.95201570 DT.40132911 DT.95201565 DT.120712074 DT.91715291 DT.95090721 DT.95103148 DT.100034579 DT.92324397 DT.95324983 DT.120712033 DT.120712043 DT.91713375 DT.100881034 DT.75120030 DT.95137931 DT.40305758 DT.120711938 DT.120712069 DT.120711924 DT.100045744 24/824 AceView cDNA sequences (see all 824): BP359716 BQ679648 BF037740 CD517934 BE792364 CR606262 BU543750 BM804991 T28041 BE264135 CR604035 BP358621 BM804287 AI310822 BF725649 AW071439 BU541638 BE718723 CD558649 BC027493 BQ073818 BI333698 AA598659 BC008345
GeneLoc Exon Structure
5/16 Alternative Splicing Database (ASD) splice patterns (SP) for NUMA1 (see all 16) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | · | 10d | ^ | 11 | ^ | 12a | · | 12b | · | 12c | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | - | | - | | - | | - | | | | - | | - | | - | | - | | - | | | | | | - | | | | | | - | | | | | | | | - | | |
| SP2: | | | | | | | | | | | - | | - | | - | | - | | - | | | | - | | - | | - | | - | | - | | | | | | - | | | | | | - | | | | | | | | - | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | - | | | | | | - | | | | | | | | - | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | - | | | | | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | - | | - | | - | | | | - | | - | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | |
| ExUns: | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | ^ | 22a | · | 22b | ^ | 23 | ^ | 24a | · | 24b | ^ | 25 | ^ | 26a | · | 26b | ^ | 27a | · | 27b | · | 27c | ^ | 28a | · | 28b |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NUMA1
|
Expression
for NUMA1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NUMA1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACAGTGTGG
About this image
See NUMA1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NUMA1
SOURCE GeneReport for Unigene cluster: Hs.325978
SABiosciences Custom PCR Arrays for NUMA1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUMA1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NUMA1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUMA1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUMA1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUMA1 |
Orthologs
for NUMA1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for NUMA1 gene from 6/14 species (see all 14) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
NUMA11 |
nuclear mitotic apparatus protein 1 |
64.48(n)
56.52(a) |
|
768717 NM_001190925.1 NP_001177854.1 |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
51(a) |
1 ↔ 1 |
GL343792.1(125536-149798) |
African clawed frog
(Xenopus laevis) |
Amphibia |
NuMA2 |
nuclear/mitotic apparatus protein |
74.13(n) |
|
Y07624.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC1003325071 |
nuclear mitotic apparatus protein 1-like |
46.18(n)
33.12(a) |
|
100332507 XM_002666750.2 XP_002666796.2 |
honey bee
(Apis mellifera) |
Insecta |
-- |
-- |
7(a) |
possible ortholog |
Group8.17(54593-62455) |
worm
(Caenorhabditis elegans) |
Secernentea |
dyf-146 |
abnormal DYe Filling family member (dyf-14) |
8(a) |
1 → many |
II(4627808-4638381) |
ENSEMBL Gene Tree for NUMA1 (if available)
TreeFam Gene Tree for NUMA1 (if available) |
Paralogs
for NUMA1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NUMA1 gene
- GOLGA42 GCC22 CEP2502 AKAP92 PCNT2 LOC7287632 CROCC2 EEA12
- TRIP112 CENPF2 CNTRL2 GOLGB12
3 SIMAP similar genes for NUMA1 using alignment to 22 protein entries: NUMA1_HUMAN (see all proteins):NuMA NUMA1 variant protein IFT81
NUMA1 for paralogs About GeneDecksing
|
Genomic Variants
for NUMA1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NUMA1 (71713910 - 71791739 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for NUMA1
1 CNV: 101257 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NUMA1 |
|
Disorders
/ Diseases
for NUMA1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NUMA1 for disorders About GeneDecksing
OMIM gene information: 164009
OMIM disorders: --
20/22  diseases for NUMA1 (see all 22): About MalaCardsleukemia, acute promyelocytic, numa/rara type acute promyelocytic leukemia breast cancer susceptibility muscular dystrophy
kaposi's sarcoma breast cancer colon cancer seminoma
colorectal cancer myeloid leukemia leukemia measles
sarcoma prostate cancer esophagitis prostatitis
arthritis thyroiditis malaria neuronitis
10 Novoseek disease relationships for NUMA1 gene About this table
Human Genome Epidemiology (HuGE) Navigator: NUMA1 (5 documents)
Export disorders for NUMA1 gene to outside databases
|
Publications
for NUMA1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NUMA1 gene, integrated from 9 sources (see all 202):
(articles sorted by number of sources associating them with NUMA1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Primary structure and microtubule-interacting domain of the SP-H antigen: a mitotic map located at the spindle pole characterized as a homologous protein to NuMA. (PubMed id 8408288)1, 2, 9 Maekawa T. and Kuriyama R. (1993)
- Mutation of the predicted p34cdc2 phosphorylation sites in NuMA impair the assembly of the mitotic spindle and block mitosis. (PubMed id 7769006)1, 2, 9 Compton D.A. and Luo C. (1995)
- NuMA is a major acceptor of poly(ADP-ribosyl)ation by tankyrase 1 in mitosis. (PubMed id 16076287)1, 2, 9 Chang W....Smith S. (2005)
- Direct binding of NuMA to tubulin is mediated by a novel sequence motif in the tail domain that bundles and stabilizes microtubules. (PubMed id 11956313)1, 2, 9 Haren L. and Merdes A. (2002)
- NuMA: an unusually long coiled-coil related protein in the mammalian nucleus. (PubMed id 1541630)1, 2, 9 Yang C.H.... Snyder M. (1992)
- Primary structure of NuMA, an intranuclear protein that defines a novel pathway for segregation of proteins at mitosis. (PubMed id 1541636)1, 2, 9 Compton D.A.... Cleveland D.W. (1992)
- Assignment of the nuclear mitotic apparatus protein NuMA gene to human chromosome 11q13. (PubMed id 8406455)1, 3, 9 Sparks C.A....Fey E.G. (1993)
- Nuclear proteins of the bovine esophageal epithelium. II. The NuMA gene gives rise to multiple mRNAs and gene products reactive with monoclonal antibody W1. (PubMed id 8505359)1, 2, 9 Tang T.K....Wu C.W. (1993)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
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External Searches for NUMA1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing NUMA1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing NUMA1 gene
(According to HUGE)
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Specialized Databases showing NUMA1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for NUMA1 gene:
Search GeneIP for patents involving NUMA1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for NUMA1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for NUMA1 | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NUMA1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUMA1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NUMA1 | | OriGene 3'-UTR Clone for NUMA1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUMA1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUMA1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NUMA1 | | OriGene Custom Protein Services for NUMA1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NUMA1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NUMA1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUMA1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUMA1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUMA1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUMA1 |
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| | Antibodies & Assays for NUMA1 (NuMA-1) |
| | | | Search Tocris compounds for NUMA1 |
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 | | | NUMA1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUMA1 |
|  |  |  | | | | ThermoFisher Antibody for NUMA1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUMA1 |
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