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Aliases for NUMA1 Gene

Aliases for NUMA1 Gene

  • Nuclear Mitotic Apparatus Protein 1 2 3
  • Nuclear Matrix Protein-22 3 4
  • SP-H Antigen 3 4
  • NMP-22 3 4
  • NUMA 3 4
  • Centrophilin Stabilizes Mitotic Spindle In Mitotic Cells 3
  • Structural Nuclear Protein 3
  • NuMA Protein 4
  • NMP22 4

External Ids for NUMA1 Gene

Summaries for NUMA1 Gene

Entrez Gene Summary for NUMA1 Gene

  • This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

GeneCards Summary for NUMA1 Gene

NUMA1 (Nuclear Mitotic Apparatus Protein 1) is a Protein Coding gene. Diseases associated with NUMA1 include leukemia, acute promyelocytic. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include structural molecule activity.

UniProtKB/Swiss-Prot for NUMA1 Gene

  • Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority if the nuclear volume. Required for maintenance and establishment of the mitotic spindle poles, functionning as a tether linking bulk microtubules of the spindle to centrosomes. May be involved in coordination of the alignment of the mitotic spindle to the cellular polarity axis, which is a prerequisite for asymmetric cell divisions.

Gene Wiki entry for NUMA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUMA1 Gene

Genomics for NUMA1 Gene

Genomic Location for NUMA1 Gene

Start:
72,002,864 bp from pter
End:
72,080,693 bp from pter
Size:
77,830 bases
Orientation:
Minus strand

Genomic View for NUMA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUMA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUMA1 Gene

Regulatory Elements for NUMA1 Gene

Proteins for NUMA1 Gene

  • Protein details for NUMA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14980-NUMA1_HUMAN
    Recommended name:
    Nuclear mitotic apparatus protein 1
    Protein Accession:
    Q14980
    Secondary Accessions:
    • H0YH75
    • Q14981
    • Q9BTE9

    Protein attributes for NUMA1 Gene

    Size:
    2115 amino acids
    Molecular mass:
    238260 Da
    Quaternary structure:
    • Homodimer. Also forms multiarm oligomers by association of C-terminal tail domains, oligomers may further assemble to form a hexagonal nuclear lattice-like network. Interacts with TNKS.
    Miscellaneous:
    • Also known as nuclear matrix protein-22/NMP-22/NMP22, an antigen used in diagnostic tests of bladder cancer.
    SequenceCaution:
    • Sequence=CAA77670.1; Type=Frameshift; Positions=1270, 1299; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NUMA1 Gene

    Alternative splice isoforms for NUMA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUMA1 Gene

Proteomics data for NUMA1 Gene at MOPED

Post-translational modifications for NUMA1 Gene

  • ADP-ribosylated by TNKS during mitosis
  • O-glycosylated during cytokinesis at sites identical or close to phosphorylation sites, this interferes with the phosphorylation status.
  • Phosphorylated in the C-terminal tail during mitosis, probably by CDK1. Phosphorylation increases solubility and promotes association with dynein and subsequent translocation to the spindle poles
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys54, Lys326, Lys358, Lys364, Lys386, Lys604, Lys616, Lys855, Lys891, Lys908, Lys1330, Lys1335, Lys1430, Lys1475, Lys1511, Lys1573, Lys1699, Lys1708, Lys1766, and Lys1821
  • Glycosylation at Ser1844

No data available for DME Specific Peptides for NUMA1 Gene

Domains for NUMA1 Gene

Protein Domains for NUMA1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

NUMA1_HUMAN
Domain:
  • The C-terminal tubulin-binding domain mediates direct binding to microtubules, independantly of dynein and dynactin, and induces their bundling and stabilization:
    • Q14980
genes like me logo Genes that share domains with NUMA1: view

No data available for Gene Families for NUMA1 Gene

Function for NUMA1 Gene

Molecular function for NUMA1 Gene

GENATLAS Biochemistry: nuclear mitotic apparatus protein
UniProtKB/Swiss-Prot Function: Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority if the nuclear volume. Required for maintenance and establishment of the mitotic spindle poles, functionning as a tether linking bulk microtubules of the spindle to centrosomes. May be involved in coordination of the alignment of the mitotic spindle to the cellular polarity axis, which is a prerequisite for asymmetric cell divisions.

Gene Ontology (GO) - Molecular Function for NUMA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0005198 structural molecule activity TAS 1541630
GO:0005515 protein binding IPI 15537540
GO:0008017 microtubule binding IEA --
genes like me logo Genes that share ontologies with NUMA1: view

Phenotypes for NUMA1 Gene

genes like me logo Genes that share phenotypes with NUMA1: view

Animal Models for NUMA1 Gene

MGI Knock Outs for NUMA1:

miRNA for NUMA1 Gene

miRTarBase miRNAs that target NUMA1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NUMA1 Gene

Localization for NUMA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUMA1 Gene

Nucleus matrix. Chromosome. Cytoplasm, cytoskeleton, spindle pole. Note=Resides in the nuclear matrix during interphases. Dissociates from condensing chromosomes during early prophase, and relocates to the spindle poles via dynein/dynamin association, it remain there until the anaphase onset. Before the complete disintegration of the nuclear lamina. As mitosis progresses it reassociates with telophase chromosomes very early during nuclear reformation, before substantial accumulation of lamins on chromosomal surfaces is evident.
Isoform Numa-m: Cytoplasm. Note=Mainly clustered at the centrosomal region.
Isoform Numa-s: Cytoplasm. Note=Mainly clustered at the centrosomal region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUMA1 Gene COMPARTMENTS Subcellular localization image for NUMA1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4
mitochondrion 2
extracellular 1

Gene Ontology (GO) - Cellular Components for NUMA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0000922 spindle pole IDA 14718566
GO:0005634 nucleus IDA 1541636
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with NUMA1: view

Pathways for NUMA1 Gene

genes like me logo Genes that share pathways with NUMA1: view

Pathways by source for NUMA1 Gene

2 Qiagen pathways for NUMA1 Gene
1 Cell Signaling Technology pathway for NUMA1 Gene

Gene Ontology (GO) - Biological Process for NUMA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000132 establishment of mitotic spindle orientation IEA --
GO:0000278 mitotic cell cycle TAS --
GO:0006997 nucleus organization TAS 1541630
GO:0007067 mitotic nuclear division IEA --
genes like me logo Genes that share ontologies with NUMA1: view

Compounds for NUMA1 Gene

(6) Novoseek inferred chemical compound relationships for NUMA1 Gene

Compound -log(P) Hits PubMed IDs
nocodazole 46.3 2
retinoic acid 40.7 3
paclitaxel 16.7 1
nacl 0 1
atp 0 1
genes like me logo Genes that share compounds with NUMA1: view

Transcripts for NUMA1 Gene

Unigene Clusters for NUMA1 Gene

Nuclear mitotic apparatus protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUMA1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11 ^ 12a · 12b · 12c ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - - - -
SP6: - -
SP7:
SP8:
SP9:
SP10: - - - - -
SP11: - - - - - - - - - - -
SP12: - - - - - - - - -
SP13:
SP14: - - - - -
SP15: -
SP16:

ExUns: 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27a · 27b · 27c ^ 28a · 28b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - - -
SP9: -
SP10:
SP11:
SP12:
SP13: -
SP14:
SP15:
SP16:

Relevant External Links for NUMA1 Gene

GeneLoc Exon Structure for
NUMA1
ECgene alternative splicing isoforms for
NUMA1

Expression for NUMA1 Gene

mRNA expression in normal human tissues for NUMA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUMA1 Gene

SOURCE GeneReport for Unigene cluster for NUMA1 Gene Hs.325978

genes like me logo Genes that share expressions with NUMA1: view

Orthologs for NUMA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NUMA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUMA1 36
  • 99.53 (n)
  • 99.24 (a)
NUMA1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NUMA1 36
  • 86.18 (n)
  • 86.18 (a)
NUMA1 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUMA1 36
  • 87.52 (n)
  • 88.78 (a)
NUMA1 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Numa1 36
  • 83.33 (n)
  • 82.97 (a)
Numa1 16
Numa1 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NUMA1 37
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUMA1 37
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Numa1 36
  • 82.84 (n)
  • 82.31 (a)
chicken
(Gallus gallus)
Aves NUMA1 36
  • 64.68 (n)
  • 56.89 (a)
NUMA1 37
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 50 (a)
OneToMany
-- 37
  • 52 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia NuMA 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100145664 36
  • 53.14 (n)
  • 44.16 (a)
zebrafish
(Danio rerio)
Actinopterygii numa1 37
  • 29 (a)
OneToMany
NUMA1 (2 of 4) 37
  • 31 (a)
OneToMany
NUMA1 (3 of 4) 37
  • 32 (a)
OneToMany
NUMA1 (4 of 4) 37
  • 35 (a)
OneToMany
Species with no ortholog for NUMA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUMA1 Gene

ENSEMBL:
Gene Tree for NUMA1 (if available)
TreeFam:
Gene Tree for NUMA1 (if available)

Paralogs for NUMA1 Gene

genes like me logo Genes that share paralogs with NUMA1: view

No data available for Paralogs for NUMA1 Gene

Variants for NUMA1 Gene

Sequence variations from dbSNP and Humsavar for NUMA1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs2503 -- 72,008,357(+) AATAG(C/T)CGGTC intron-variant
rs482197 -- 72,070,201(+) AGAAA(A/G)CTTCT intron-variant
rs510938 -- 72,057,590(-) atttt(G/T)gtatt intron-variant
rs541228 -- 72,056,550(-) AAGGT(C/G)AGGAG intron-variant
rs547208 -- 72,068,622(-) TTTTT(C/T)CCAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUMA1 Gene

Variant ID Type Subtype PubMed ID
nsv428262 CNV Gain+Loss 18775914
esv2494956 CNV Deletion 19546169
nsv384 CNV Insertion 18451855

Relevant External Links for NUMA1 Gene

HapMap Linkage Disequilibrium report
NUMA1
Human Gene Mutation Database (HGMD)
NUMA1

Disorders for NUMA1 Gene

(10) Novoseek inferred disease relationships for NUMA1 Gene

Disease -log(P) Hits PubMed IDs
glioma 12.1 1
leukemia 1.6 1
colon cancer 0.998 1
necrosis 0 1
shock 0 3

Relevant External Links for NUMA1

Genetic Association Database (GAD)
NUMA1
Human Genome Epidemiology (HuGE) Navigator
NUMA1
genes like me logo Genes that share disorders with NUMA1: view

No data available for UniProtKB/Swiss-Prot for NUMA1 Gene

Publications for NUMA1 Gene

  1. NuMA: an unusually long coiled-coil related protein in the mammalian nucleus. (PMID: 1541630) Yang C.H. … Snyder M. (J. Cell Biol. 1992) 3 4 23
  2. Primary structure of NuMA, an intranuclear protein that defines a novel pathway for segregation of proteins at mitosis. (PMID: 1541636) Compton D.A. … Cleveland D.W. (J. Cell Biol. 1992) 3 4 23
  3. Mutation of the predicted p34cdc2 phosphorylation sites in NuMA impair the assembly of the mitotic spindle and block mitosis. (PMID: 7769006) Compton D.A. … Luo C. (J. Cell Sci. 1995) 3 4 23
  4. Assignment of the nuclear mitotic apparatus protein NuMA gene to human chromosome 11q13. (PMID: 8406455) Sparks C.A. … Fey E.G. (Genomics 1993) 2 3 23
  5. Primary structure and microtubule-interacting domain of the SP-H antigen: a mitotic map located at the spindle pole characterized as a homologous protein to NuMA. (PMID: 8408288) Maekawa T. … Kuriyama R. (J. Cell Sci. 1993) 3 4 23

Products for NUMA1 Gene

  • Addgene plasmids for NUMA1

Sources for NUMA1 Gene

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