Aliases for NUMA1 Gene
External Ids for NUMA1 Gene
Previous GeneCards Identifiers for NUMA1 Gene
This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
GeneCards Summary for NUMA1 Gene
NUMA1 (Nuclear Mitotic Apparatus Protein 1) is a Protein Coding gene. Diseases associated with NUMA1 include Leukemia, Acute Promyelocytic, Somatic and Acute Promyelocytic Leukemia Numa/Rara Type. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Apoptosis and survival Caspase cascade. GO annotations related to this gene include nucleotide binding and microtubule binding.
UniProtKB/Swiss-Prot for NUMA1 Gene
Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority if the nuclear volume (PubMed:10075938). Required for maintenance and establishment of the mitotic spindle poles during symmetric cell divisions, functioning as a tether linking bulk microtubules of the spindle to centrosomes (PubMed:7769006, PubMed:11956313, PubMed:26195665). Also required for proper alignment of the mitotic spindle during asymmetric cell divisions (PubMed:21816348).