NUGGC Gene
protein-coding GIFtS: 33
GCID: GC08M027879
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nuclear GTPase, germinal center associated(Previous name: chromosome 8 open reading frame 80 )
(Previous symbol: C8orf80)
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Aliases
for NUGGC gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
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| Nuclear GTPase, Germinal Center Associated1 2 | | Chromosome 8 Open Reading Frame 801 | | C8orf801 2 3 | | GTPase SLIP-GC2 | | SLIP-GC1 2 | | Nuclear GTPase SLIP-GC2 | | Speckled-Like Pattern In The Germinal Center2 3 | | EC 3.6.1.-3 | | HMFN06721 | | |
Export aliases for NUGGC gene to outside databases |
Summaries
for NUGGC gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SLIP_HUMAN, Q68CJ6Function: Plays a role as replication-related GTPase protein in germinal center B-cell
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Genomic Views
for NUGGC gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_167187.1
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for NUGGC
Other transcription factors
Search SABiosciences Chromatin IP Primers for NUGGC
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUGGC |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8p21.1 Ensembl cytogenetic band: 8p21.1 HGNC cytogenetic band: 8p21.1NUGGC Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M027879: view genomic region
(about GC identifiers)
Start:
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27,879,481 bp from pter |
End:
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27,941,388 bp from pter |
Size:
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61,908 bases |
Orientation:
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minus strand |
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Proteins
for NUGGC gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SLIP_HUMAN, Q68CJ6 (See
protein sequence)Recommended Name: Nuclear GTPase SLIP-GC Size: 796 amino acids; 91132 Da
Subcellular location: Nucleus
Sequence caution: Sequence=BAC85251.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=BAD38652.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
Secondary accessions: Q6ZP73Explore the universe of human proteins at neXtProt for NUGGC: NX_Q68CJ6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q68CJ6
NUGGC Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001010906.1
ENSEMBL proteins: ENSP00000408697 ENSP00000388515 ENSP00000345031
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
NUGGC for ontologies About GeneDecksing
NUGGC Antibody Products:
Assay Products for NUGGC: |
Protein
Domains /
Families
for NUGGC gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NUGGC for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q68CJ6ProtoNet protein and cluster: Q68CJ6 |
Function
for NUGGC gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SLIP_HUMAN, Q68CJ6Function: Plays a role as replication-related GTPase protein in germinal center B-cellEnzyme Number (IUBMB): EC 3.6.1.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUGGC
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUGGC
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for NUGGC | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUGGC |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUGGC |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
NUGGC for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Nuggctm1.1Diaz for NUGGC
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Nuggc):
NUGGC for phenotypes About GeneDecksing
|
Pathways & Interactions
for NUGGC gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NUGGC
|
Drugs & Compounds
for NUGGC gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NUGGC
Search CenterWatch for drugs/clinical trials and news about NUGGC / SLIP
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Transcripts
for NUGGC gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NUGGC gene: NM_001010906.1 Unigene Cluster for NUGGC: Nuclear GTPase, germinal center associated Hs.370129 [show with all ESTs]Unigene Representative Sequence: NM_0010109063 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000413272(uc003xgm.4) ENST00000418860 ENST00000341513
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUGGC
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUGGC
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for NUGGC | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NUGGC | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUGGC |
Additional cDNA sequence: AB075870.1 AK129923.1 6 DOTS entries: DT.440732 DT.101980002 DT.121492288 DT.40283317 DT.97769475 DT.95358652 22 AceView cDNA sequences: BX280763 AA243356 AA482187 AI479236 BE514093 AA255972 AI928030 AA482282 AB075870 CF137482 AA284374 AA768146 AI935423 AW504479 CF138718 AK129923 AW968887 CF136851 AA256145 AW408829 BU429067 AA927797
GeneLoc Exon Structure
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Expression
for NUGGC gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
See NUGGC Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.370129
UniProtKB/Swiss-Prot: SLIP_HUMAN, Q68CJ6Tissue specificity: Expressed in germinal center B-cell and in lymphomas derived from germinal center B-cell
SABiosciences Custom PCR Arrays for NUGGC
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUGGC
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat NUGGC | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUGGC | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUGGC | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUGGC |
Orthologs
for NUGGC gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for NUGGC gene from 4/12 species (see all 12) About this table
ENSEMBL Gene Tree for NUGGC (if available)
TreeFam Gene Tree for NUGGC (if available) |
Paralogs
for NUGGC gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for NUGGC gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for NUGGC (27879481 - 27941388 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NUGGC: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NUGGC |
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Disorders
/ Diseases
for NUGGC gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NUGGC for disorders About GeneDecksing
2  diseases for NUGGC: About MalaCardshepatoblastoma b-cell lymphomas
Export disorders for NUGGC gene to outside databases
|
Publications
for NUGGC gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NUGGC gene integrated from 9 sources:
(articles sorted by number of sources associating them with NUGGC) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Speckled-like pattern in the germinal center (SLIP-GC): a nuclear GTPase expressed in activation-induced deaminase-expressing lymphomas and germinal center B cells. (PubMed id 19734146)1, 2, 3 Richter K....Diaz M. (2009)
- Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PubMed id 15221005)1, 2 Yamada S....Nakagawara A. (2004)
- Altered pattern of immunoglobulin hypermutation in mic e deficient in Slip-GC protein. (PubMed id 22833677)1 Richter K....Diaz M. (2012)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Genome-wide association study of increasing suicidal ideation during antidepressant treatment in the GENDEP project. (PubMed id 20877300)1 Perroud N....McGuffin P. (2010)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1 Rush J.... Comb M.J. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
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External Searches for NUGGC gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing NUGGC gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing NUGGC gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NUGGC gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NUGGC | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for NUGGC gene:
Search GeneIP for patents involving NUGGC
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NUGGC gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NUGGC | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NUGGC | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUGGC | | | OriGene Protein Over-expression Lysate for NUGGC | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NUGGC | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUGGC | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUGGC | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NUGGC | | OriGene Custom Protein Services for NUGGC | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NUGGC | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NUGGC | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUGGC | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUGGC | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUGGC | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUGGC |
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| | | | Search Tocris compounds for NUGGC |
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 | | | NUGGC Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUGGC |
|  |  |  | | | | Search ThermoFisher Antibodies for NUGGC |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUGGC |
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