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Aliases for NUGGC Gene

Aliases for NUGGC Gene

  • Nuclear GTPase, Germinal Center Associated 2 3 5
  • Speckled-Like Pattern In The Germinal Center 2 3 4
  • C8orf80 3 4
  • Chromosome 8 Open Reading Frame 80 2
  • Nuclear GTPase SLIP-GC 3
  • GTPase SLIP-GC 3
  • EC 3.6.1.- 4
  • HMFN0672 3
  • SLIP-GC 3

External Ids for NUGGC Gene

Previous HGNC Symbols for NUGGC Gene

  • C8orf80

Previous GeneCards Identifiers for NUGGC Gene

  • GC08M027879

Summaries for NUGGC Gene

GeneCards Summary for NUGGC Gene

NUGGC (Nuclear GTPase, Germinal Center Associated) is a Protein Coding gene. GO annotations related to this gene include GTP binding and GTPase activity.

UniProtKB/Swiss-Prot for NUGGC Gene

  • Nuclear GTPase found in germinal center B-cells, where it may inhibit function of the activation-induced cytidine deaminase AICDA (PubMed:19734146). Reduces somatic hypermutation in B-cells which may enhance genome stability (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUGGC Gene

Genomics for NUGGC Gene

Regulatory Elements for NUGGC Gene

Enhancers for NUGGC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F028061 0.2 ENCODE 11.4 +22.8 22825 0.2 CTCF PKNOX1 ARID4B MAX ZNF2 RAD21 HBP1 TEAD3 ZNF143 SMC3 NUGGC PNOC SCARA5
GH08F027855 0.5 ENCODE 10.2 +227.6 227604 1.3 CTCF CBX3 REST RFX5 CHAMP1 GTF3C2 ATF3 ZNF512 ZNF580 SMC3 CCDC25 ZNF395 SCARA5 NUGGC LOC100130612 MIR4287
GH08F028319 1.1 Ensembl ENCODE 10.2 -235.6 -235602 1.3 STAT1 TAL1 ARID1B GATA2 HDAC2 STAT2 PBX2 PRDM10 KDM1A TRIM28 NUGGC PNOC ENSG00000253690
GH08F028346 1.1 Ensembl ENCODE 9.8 -266.1 -266073 7.9 HDGF TBP PKNOX1 SIN3A ZBTB40 ZNF121 ZNF766 HSF1 FOS SMARCC1 FZD3 FBXO16 EXTL3 NUGGC PNOC PIR39512 ZNF395
GH08F028355 0.2 ENCODE 9.5 -271.7 -271676 0.2 CTCF PKNOX1 CBX3 TRIM22 REST RAD21 SMC3 ZBTB33 PRDM1 SPI1 ZNF395 FZD3 FBXO16 EXTL3 PNOC NUGGC PIR39512
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NUGGC on UCSC Golden Path with GeneCards custom track

Genomic Location for NUGGC Gene

Chromosome:
8
Start:
28,021,964 bp from pter
End:
28,084,063 bp from pter
Size:
62,100 bases
Orientation:
Minus strand

Genomic View for NUGGC Gene

Genes around NUGGC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUGGC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUGGC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUGGC Gene

Proteins for NUGGC Gene

  • Protein details for NUGGC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68CJ6-SLIP_HUMAN
    Recommended name:
    Nuclear GTPase SLIP-GC
    Protein Accession:
    Q68CJ6
    Secondary Accessions:
    • Q6ZP73

    Protein attributes for NUGGC Gene

    Size:
    796 amino acids
    Molecular mass:
    91132 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC85251.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD38652.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

neXtProt entry for NUGGC Gene

Post-translational modifications for NUGGC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUGGC Gene

No data available for DME Specific Peptides for NUGGC Gene

Domains & Families for NUGGC Gene

Protein Domains for NUGGC Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NUGGC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NUGGC: view

No data available for Gene Families and UniProtKB/Swiss-Prot for NUGGC Gene

Function for NUGGC Gene

Molecular function for NUGGC Gene

UniProtKB/Swiss-Prot Function:
Nuclear GTPase found in germinal center B-cells, where it may inhibit function of the activation-induced cytidine deaminase AICDA (PubMed:19734146). Reduces somatic hypermutation in B-cells which may enhance genome stability (By similarity).

Enzyme Numbers (IUBMB) for NUGGC Gene

Gene Ontology (GO) - Molecular Function for NUGGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with NUGGC: view
genes like me logo Genes that share phenotypes with NUGGC: view

Animal Models for NUGGC Gene

MGI Knock Outs for NUGGC:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NUGGC Gene

Localization for NUGGC Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUGGC Gene

Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUGGC Gene COMPARTMENTS Subcellular localization image for NUGGC gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NUGGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with NUGGC: view

Pathways & Interactions for NUGGC Gene

SuperPathways for NUGGC Gene

No Data Available

Interacting Proteins for NUGGC Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000408697%0d%0a9606.ENSP00000301838%0d%0a
Selected Interacting proteins: ENSP00000408697 for NUGGC Gene via STRING

Symbol External ID(s) Details
FADD

Gene Ontology (GO) - Biological Process for NUGGC Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NUGGC Gene

Transcripts for NUGGC Gene

mRNA/cDNA for NUGGC Gene

Unigene Clusters for NUGGC Gene

Nuclear GTPase, germinal center associated:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUGGC Gene

No ASD Table

Relevant External Links for NUGGC Gene

GeneLoc Exon Structure for
NUGGC
ECgene alternative splicing isoforms for
NUGGC

Expression for NUGGC Gene

mRNA expression in normal human tissues for NUGGC Gene

mRNA differential expression in normal tissues according to GTEx for NUGGC Gene

This gene is overexpressed in Liver (x20.2) and Spleen (x4.1).

Protein differential expression in normal tissues from HIPED for NUGGC Gene

This gene is overexpressed in Frontal cortex (21.5), Heart (17.8), Skin (17.4), and Esophagus (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NUGGC Gene



Protein tissue co-expression partners for NUGGC Gene

NURSA nuclear receptor signaling pathways regulating expression of NUGGC Gene:

NUGGC

SOURCE GeneReport for Unigene cluster for NUGGC Gene:

Hs.370129

mRNA Expression by UniProt/SwissProt for NUGGC Gene:

Q68CJ6-SLIP_HUMAN
Tissue specificity: Expressed in germinal center B-cell and in lymphomas derived from germinal center B-cell.
genes like me logo Genes that share expression patterns with NUGGC: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for NUGGC Gene

Orthologs for NUGGC Gene

This gene was present in the common ancestor of chordates.

Orthologs for NUGGC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUGGC 34 35
  • 99.29 (n)
cow
(Bos Taurus)
Mammalia NUGGC 34 35
  • 86.06 (n)
dog
(Canis familiaris)
Mammalia NUGGC 34 35
  • 86.06 (n)
rat
(Rattus norvegicus)
Mammalia Nuggc 34
  • 81.83 (n)
mouse
(Mus musculus)
Mammalia Nuggc 34 16 35
  • 81.69 (n)
oppossum
(Monodelphis domestica)
Mammalia NUGGC 35
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUGGC 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves C3H8ORF80 34
  • 58.78 (n)
-- 35
  • 48 (a)
OneToMany
-- 35
  • 42 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia NUGGC 35
  • 37 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:dkeyp-85e10.1 34
  • 43.13 (n)
NUGGC (3 of 4) 35
  • 20 (a)
OneToMany
NUGGC (1 of 4) 35
  • 18 (a)
OneToMany
NUGGC (4 of 4) 35
  • 17 (a)
OneToMany
NUGGC (2 of 4) 35
  • 12 (a)
OneToMany
Species where no ortholog for NUGGC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUGGC Gene

ENSEMBL:
Gene Tree for NUGGC (if available)
TreeFam:
Gene Tree for NUGGC (if available)

Paralogs for NUGGC Gene

No data available for Paralogs for NUGGC Gene

Variants for NUGGC Gene

Sequence variations from dbSNP and Humsavar for NUGGC Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000658 -- 28,048,082(+) CTGTT(C/T)CAGTC intron-variant
rs10046724 -- 28,022,638(+) AGAAA(A/G)AATTC utr-variant-3-prime
rs10081617 -- 28,082,697(+) cccag(G/T)agctt intron-variant
rs10088772 -- 28,025,718(+) AGAAC(A/G)GATTG intron-variant
rs10093400 -- 28,068,279(+) TGTAC(A/T)ATGCA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for NUGGC Gene

Variant ID Type Subtype PubMed ID
esv3616733 CNV loss 21293372
esv3616734 CNV loss 21293372
nsv521155 CNV loss 19592680
nsv524295 CNV loss 19592680

Variation tolerance for NUGGC Gene

Residual Variation Intolerance Score: 88.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.70; 89.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUGGC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUGGC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUGGC Gene

Disorders for NUGGC Gene

Relevant External Links for NUGGC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUGGC

No disorders were found for NUGGC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUGGC Gene

Publications for NUGGC Gene

  1. Speckled-like pattern in the germinal center (SLIP-GC): a nuclear GTPase expressed in activation-induced deaminase-expressing lymphomas and germinal center B cells. (PMID: 19734146) Richter K. … Diaz M. (J. Biol. Chem. 2009) 2 3 4 64
  2. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PMID: 15221005) Yamada S. … Nakagawara A. (Oncogene 2004) 3 4 64
  3. Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies. (PMID: 23247143) Yu B. … Boerwinkle E. (Circ Cardiovasc Genet 2013) 3 64
  4. Genome-wide association study of increasing suicidal ideation during antidepressant treatment in the GENDEP project. (PMID: 20877300) Perroud N. … McGuffin P. (Pharmacogenomics J. 2012) 3 64
  5. Altered pattern of immunoglobulin hypermutation in mice deficient in Slip-GC protein. (PMID: 22833677) Richter K. … Diaz M. (J. Biol. Chem. 2012) 3 64

Products for NUGGC Gene

Sources for NUGGC Gene

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