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Aliases for NUGGC Gene

Aliases for NUGGC Gene

  • Nuclear GTPase, Germinal Center Associated 2 3
  • Speckled-Like Pattern In The Germinal Center 2 3 4
  • C8orf80 3 4
  • Chromosome 8 Open Reading Frame 80 2
  • GTPase SLIP-GC 3
  • EC 3.6.1.- 4
  • HMFN0672 3
  • SLIP-GC 3

External Ids for NUGGC Gene

Previous HGNC Symbols for NUGGC Gene

  • C8orf80

Previous GeneCards Identifiers for NUGGC Gene

  • GC08M027879

Summaries for NUGGC Gene

GeneCards Summary for NUGGC Gene

NUGGC (Nuclear GTPase, Germinal Center Associated) is a Protein Coding gene. GO annotations related to this gene include GTP binding and GTPase activity.

UniProtKB/Swiss-Prot for NUGGC Gene

  • Plays a role as replication-related GTPase protein in germinal center B-cell.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUGGC Gene

Genomics for NUGGC Gene

Genomic Location for NUGGC Gene

Chromosome:
8
Start:
28,021,964 bp from pter
End:
28,084,063 bp from pter
Size:
62,100 bases
Orientation:
Minus strand

Genomic View for NUGGC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUGGC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUGGC Gene

No data available for Regulatory Elements for NUGGC Gene

Proteins for NUGGC Gene

  • Protein details for NUGGC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68CJ6-SLIP_HUMAN
    Recommended name:
    Nuclear GTPase SLIP-GC
    Protein Accession:
    Q68CJ6
    Secondary Accessions:
    • Q6ZP73

    Protein attributes for NUGGC Gene

    Size:
    796 amino acids
    Molecular mass:
    91132 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC85251.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD38652.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

neXtProt entry for NUGGC Gene

Proteomics data for NUGGC Gene at MOPED

Post-translational modifications for NUGGC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUGGC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NUGGC Gene

Domains & Families for NUGGC Gene

Protein Domains for NUGGC Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NUGGC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NUGGC: view

No data available for Gene Families and UniProtKB/Swiss-Prot for NUGGC Gene

Function for NUGGC Gene

Molecular function for NUGGC Gene

UniProtKB/Swiss-Prot Function:
Plays a role as replication-related GTPase protein in germinal center B-cell.

Enzyme Numbers (IUBMB) for NUGGC Gene

Gene Ontology (GO) - Molecular Function for NUGGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with NUGGC: view
genes like me logo Genes that share phenotypes with NUGGC: view

Animal Models for NUGGC Gene

MGI Knock Outs for NUGGC:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NUGGC

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for NUGGC Gene

Localization for NUGGC Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUGGC Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUGGC Gene COMPARTMENTS Subcellular localization image for NUGGC gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for NUGGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with NUGGC: view

Pathways & Interactions for NUGGC Gene

SuperPathways for NUGGC Gene

No Data Available

Interacting Proteins for NUGGC Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000408697%0d%0a9606.ENSP00000301838%0d%0a
Selected Interacting proteins: ENSP00000408697 for NUGGC Gene via STRING

Symbol External ID(s) Details
FADD

Gene Ontology (GO) - Biological Process for NUGGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0008152 metabolic process IEA --
GO:0016446 somatic hypermutation of immunoglobulin genes IEA --
genes like me logo Genes that share ontologies with NUGGC: view

No data available for Pathways by source and SIGNOR curated interactions for NUGGC Gene

Drugs & Compounds for NUGGC Gene

No Compound Related Data Available

Transcripts for NUGGC Gene

mRNA/cDNA for NUGGC Gene

Unigene Clusters for NUGGC Gene

Nuclear GTPase, germinal center associated:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NUGGC

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUGGC Gene

No ASD Table

Relevant External Links for NUGGC Gene

GeneLoc Exon Structure for
NUGGC
ECgene alternative splicing isoforms for
NUGGC

Expression for NUGGC Gene

mRNA expression in normal human tissues for NUGGC Gene

mRNA differential expression in normal tissues according to GTEx for NUGGC Gene

This gene is overexpressed in Liver (x20.2) and Spleen (x4.1).

Protein differential expression in normal tissues from HIPED for NUGGC Gene

This gene is overexpressed in Frontal cortex (21.5), Heart (17.8), Skin (17.4), and Esophagus (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NUGGC Gene



SOURCE GeneReport for Unigene cluster for NUGGC Gene Hs.370129

mRNA Expression by UniProt/SwissProt for NUGGC Gene

Q68CJ6-SLIP_HUMAN
Tissue specificity: Expressed in germinal center B-cell and in lymphomas derived from germinal center B-cell.
genes like me logo Genes that share expression patterns with NUGGC: view

Protein tissue co-expression partners for NUGGC Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for NUGGC Gene

Orthologs for NUGGC Gene

This gene was present in the common ancestor of chordates.

Orthologs for NUGGC Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NUGGC 35
  • 86.06 (n)
  • 85.14 (a)
NUGGC 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUGGC 35
  • 86.06 (n)
  • 85.68 (a)
NUGGC 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nuggc 35
  • 81.69 (n)
  • 79.18 (a)
Nuggc 16
Nuggc 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NUGGC 35
  • 99.29 (n)
  • 98.99 (a)
NUGGC 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nuggc 35
  • 81.83 (n)
  • 80.15 (a)
oppossum
(Monodelphis domestica)
Mammalia NUGGC 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUGGC 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves C3H8ORF80 35
  • 58.78 (n)
  • 49.1 (a)
-- 36
  • 48 (a)
OneToMany
-- 36
  • 42 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia NUGGC 36
  • 37 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:dkeyp-85e10.1 35
  • 43.13 (n)
  • 28.66 (a)
NUGGC (1 of 4) 36
  • 18 (a)
OneToMany
NUGGC (2 of 4) 36
  • 12 (a)
OneToMany
NUGGC (3 of 4) 36
  • 20 (a)
OneToMany
NUGGC (4 of 4) 36
  • 17 (a)
OneToMany
Species with no ortholog for NUGGC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUGGC Gene

ENSEMBL:
Gene Tree for NUGGC (if available)
TreeFam:
Gene Tree for NUGGC (if available)

Paralogs for NUGGC Gene

No data available for Paralogs for NUGGC Gene

Variants for NUGGC Gene

Sequence variations from dbSNP and Humsavar for NUGGC Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs735880 -- 28,053,510(-) CATGC(C/T)GTTGT intron-variant
rs921597 -- 28,023,309(-) CCTGG(A/G)GCTTA utr-variant-3-prime
rs971882 -- 28,078,680(+) TGAAA(A/C)TGAGA intron-variant, upstream-variant-2KB
rs997549 -- 28,022,078(-) ATATC(A/C/G/T)TGCAA utr-variant-3-prime, downstream-variant-500B
rs999112 -- 28,049,407(-) AACTG(C/T)TTTAA intron-variant

Variation tolerance for NUGGC Gene

Residual Variation Intolerance Score: 88.78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.70; 89.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUGGC Gene

HapMap Linkage Disequilibrium report
NUGGC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NUGGC Gene

Disorders for NUGGC Gene

Relevant External Links for NUGGC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUGGC
genes like me logo Genes that share disorders with NUGGC: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUGGC Gene

Publications for NUGGC Gene

  1. Speckled-like pattern in the germinal center (SLIP-GC): a nuclear GTPase expressed in activation-induced deaminase-expressing lymphomas and germinal center B cells. (PMID: 19734146) Richter K. … Diaz M. (J. Biol. Chem. 2009) 2 67
  2. Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies. (PMID: 23247143) Yu B. … Boerwinkle E. (Circ Cardiovasc Genet 2013) 67
  3. Altered pattern of immunoglobulin hypermutation in mice deficient in Slip-GC protein. (PMID: 22833677) Richter K. … Diaz M. (J. Biol. Chem. 2012) 67
  4. Genome-wide association study of increasing suicidal ideation during antidepressant treatment in the GENDEP project. (PMID: 20877300) Perroud N. … McGuffin P. (Pharmacogenomics J. 2012) 67
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 67

Products for NUGGC Gene

Sources for NUGGC Gene

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