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NUF2 Gene

protein-coding   GIFtS: 59
GCID: GC01P163236

NUF2, NDC80 Kinetochore Complex Component

(Previous names: cell division cycle associated 1, NUF2, NDC80 kinetochore...)
(Previous symbol: CDCA1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NUF2, NDC80 Kinetochore Complex Component1 2     hNuf2R2 3
CDCA11 2 3 5     hsNuf22 3
NUF2R2 3 5     NUF2, NDC80 Kinetochore Complex Component, Homolog (S. Cerevisiae)1
Cell Division Cycle Associated 11 2     CT1062
Cancer/Testis Antigen 1061 2     Kinetochore Protein Nuf22
Cell Division Cycle-Associated Protein 12 3     NUF2, NDC80 Kinetochore Complex Component, Homolog2
hNuf22 3     

External Ids:    HGNC: 146211   Entrez Gene: 835402   Ensembl: ENSG000001432287   OMIM: 6117725   UniProtKB: Q9BZD43   

Export aliases for NUF2 gene to outside databases

Previous GC identifers: GC01P161559 GC01P163291 GC01P134537


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NUF2 Gene:
This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex
associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when
centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome
segregation. The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests
that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode
the same protein have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for NUF2 Gene:
NUF2 (NUF2, NDC80 kinetochore complex component) is a protein-coding gene. Diseases associated with NUF2 include duodenogastric reflux, and pulmonary function.

UniProtKB/Swiss-Prot: NUF2_HUMAN, Q9BZD4
Function: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for
chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization
of stable microtubule binding sites in the outer plate of the kinetochore

Gene Wiki entry for NUF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the NUF2 gene promoter:
         GR   C/EBPbeta   Sox5   FOXD3   POU6F1 (c2)   LCR-F1   MEF-2A   HFH-1   GR-alpha   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNUF2 promoter sequence
   Search Chromatin IP Primers for NUF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NUF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.3   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q23.3

NUF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUF2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P163236:  view genomic region     (about GC identifiers)

Start:
163,236,366 bp from pter      End:
163,325,554 bp from pter
Size:
89,189 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NUF2_HUMAN, Q9BZD4 (See protein sequence)
Recommended Name: Kinetochore protein Nuf2  
Size: 464 amino acids; 54304 Da
Subunit: Component of the NDC80 complex, which consists of NDC80/HEC1, CDCA1, SPBC24 and SPBC25. The NDC80 complex
is formed by two subcomplexes composed of NDC80/HEC1-CDCA1 and SPBC24-SPBC25. Each subcomplex is formed by
parallel interactions through the coiled-coil domains of individual subunits. Formation of a tetrameric complex
is mediated by interactions between the C-terminal regions of both subunits of the NDC80/HEC1-CDCA1 subcomplex
and the N-terminal regions of both subunits of the SPBC24-SPBC25 complex. The tetrameric NDC80 complex has an
elongated rod-like structure with globular domains at either end. May interact with AURKB/Aurora-B. Directly
interacts with CENPE; this interaction determines CENPE kinetochore localization
2 PDB 3D structures from and Proteopedia for NUF2:
2VE7 (3D)        3IZ0 (3D)    
Secondary accessions: Q8WU69 Q96HJ4 Q96Q78

Explore the universe of human proteins at neXtProt for NUF2: NX_Q9BZD4

Explore proteomics data for NUF2 at MOPED

Post-translational modifications: 

  • Can be phosphorylated by AURKA and AURKB1
  • Ubiquitination2 at Lys299, Lys383, Lys402, Lys418
  • Modification sites at PhosphoSitePlus

  • See NUF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_113611.2  NP_663735.2  

    ENSEMBL proteins: 
     ENSP00000433533   ENSP00000403252   ENSP00000436888   ENSP00000392652   ENSP00000356875  
     ENSP00000271452   ENSP00000436473  
    Reactome Protein details: Q9BZD4

    NUF2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR005549 Kinetochore_Nuf2

    Graphical View of Domain Structure for InterPro Entry Q9BZD4

    ProtoNet protein and cluster: Q9BZD4

    UniProtKB/Swiss-Prot: NUF2_HUMAN, Q9BZD4
    Similarity: Belongs to the NUF2 family


    NUF2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NUF2_HUMAN, Q9BZD4
    Function: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for
    chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization
    of stable microtubule binding sites in the outer plate of the kinetochore

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding IPI14699129
         
    NUF2 for ontologies           About GeneDecksing


    Phenotypes:
         10 GenomeRNAi human phenotypes for NUF2:
     Abundance of large cells with   Cell cycle / mitosis defect  Decreased Hepatitis C virus re  Decreased viability of wild-ty 
     Increased S DNA content  Increased Salmonella enterica   Increased Salmonella enterica   Increased gamma-H2AX phosphory 
     Increased number of cells in m  Increased number of mitotic ce 

    Animal Models:
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    miRNA
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    Block miRNA regulation of human, mouse, rat NUF2 using miScript Target Protectors
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NUF2_HUMAN, Q9BZD4: Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late
    prophase to anaphase. Localizes specifically to the outer plate of the kinetochore. NDC80 is required for
    efficient kinetochore localization
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region NAS11266451
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--
    GO:0031262Ndc80 complex IDA14699129

    NUF2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NUF2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    3Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Resolution of Sister Chromatid Cohesion0.92

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3 Reactome Pathways for NUF2
        Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Separation of Sister Chromatids



    NUF2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NUF2
    Interactions:

        GeneGlobe Interaction Network for NUF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NUF2 (Q9BZD41, 2, 3 ENSP000002714524) via UniProtKB, MINT, STRING, and/or I2D (see all 909)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NDC80O147771, 2, 3, ENSP000002615974EBI-724102,EBI-715849 MINT-7945693 MINT-7947479 I2D: score=4 STRING: ENSP00000261597
    BUB1O436832, 3, ENSP000003025304MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000302530
    CENPEQ022241, 3, ENSP000002651484EBI-724102,EBI-1375040 I2D: score=2 STRING: ENSP00000265148
    EXOC1Q9NV702, 3, ENSP000003265144MINT-7945693 I2D: score=2 STRING: ENSP00000326514
    AURKBQ96GD42, 3, ENSP000003139504MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000313950
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0007059chromosome segregation NAS11266451
    GO:0007067mitosis IEA--

    NUF2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NUF2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NUF2 gene (2 alternative transcripts): 
    NM_031423.3  NM_145697.2  

    Unigene Cluster for NUF2:

    NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
    Hs.651950  [show with all ESTs]
    Unigene Representative Sequence: NM_145697
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000534289 ENST00000450453 ENST00000524800 ENST00000442820 ENST00000367900(uc001gcr.1)
    ENST00000271452(uc001gcq.1) ENST00000490881 ENST00000487578 ENST00000497990
    ENST00000527439 ENST00000527120 ENST00000531529
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat NUF2
      QuantiFast Probe-based Assays in human, mouse, rat NUF2

    Additional mRNA sequence: 

    AB050577.1 AB050578.1 AF326731.1 AK093348.1 BC008489.1 BC021171.2 

    15 DOTS entries:

    DT.91717067  DT.100818709  DT.95272793  DT.95272795  DT.410980  DT.100818708  DT.121444525  DT.100842852 
    DT.121444490  DT.40118894  DT.75186952  DT.95272794  DT.95272796  DT.95272798  DT.99966185 

    Selected AceView cDNA sequences (see all 108):

    AA383719 CR619637 AL531815 AI081570 AI038782 AW197999 BU622548 AA764964 
    BU521688 AW001937 BX443441 AK093348 BX283986 CA428550 AB050578 AW662200 
    AX748068 BE882537 BG354574 BC008489 CR605406 AW239243 AI015982 BG119621 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NUF2 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                                -                       -                                                                 -         
    SP2:                          -     -                       -                                                                 -         
    SP3:                          -                             -                                                                           
    SP4:                                                        -                                                                           
    SP5:                                -                                                                                                   


    ECgene alternative splicing isoforms for NUF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NUF2 expression in normal human tissues (normalized intensities)      NUF2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTCTACTCT
    NUF2 Expression
    About this image


    NUF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Choroid Plexus Progenitor Cells Choroid Plexus
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Presumptive Podocytes Podocyte Layer
             Metanephros
     
     Intermediate Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Mesonephric cells Mesonephros
             Mesonephros
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
    NUF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NUF2 Protein Expression

    Genevestigator expression for NUF2

    SOURCE GeneReport for Unigene cluster: Hs.651950
        Custom PCR Arrays for NUF2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NUF2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nuf21 , 5 NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae) less1, 5 79.8(n)1
    73.38(a)1
      1 (76.84 cM)5
    669771  NM_023284.31  NP_075773.21 
     1694979345 
    chicken
    (Gallus gallus)
    Aves NUF21 NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae) less 66.59(n)
    58.41(a)
      395135  NM_204478.3  NP_989809.2 
    lizard
    (Anolis carolinensis)
    Reptilia NUF26
    NUF2, NDC80 kinetochore complex component
    47(a)
    1 ↔ 1
    GL343405.1(330568-361941)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.43922 Transcribed sequence with weak similarity to protein refNP_113611.1 (H.sapiens) hypothetical protein NUF2R [Homo sapiens] less 70.4(n)    142034571 
    zebrafish
    (Danio rerio)
    Actinopterygii nuf21 NUF2, NDC80 kinetochore complex component, homolog 47.54(n)
    34.79(a)
      393280  NM_200310.1  NP_956604.1 


    ENSEMBL Gene Tree for NUF2 (if available)
    TreeFam Gene Tree for NUF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NUF2 (see all 708)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs590169681,2
    C,F--163293628(+) CAACAA/GGAACA 2 -- int12Minor allele frequency- G:0.04WA 120
    rs113766761,2
    C--163293777(+) CATTAA/-TACTG 2 -- int11Minor allele frequency- -:0.00NA 2
    rs2018671171,2
    C--163293777(+) GCCATA/TATACT 2 -- int10--------
    rs763936241,2
    C,F--163293909(+) GTCATA/GTAAGG 2 -- int12Minor allele frequency- G:0.03WA EA 238
    rs105878551,2
    C--163294033(+) taaac-/AGagatt 2 -- int10--------
    rs618122141,2
    F--163294198(+) ACATGT/ATCAAG 2 -- int12Minor allele frequency- A:0.03NA 122
    rs1928390541,2
    --163294225(+) TTTGTA/TAGTGG 2 -- int10--------
    rs114218671,2
    C--163294303(+) ATTCTA/-AAAAA 2 -- int12Minor allele frequency- -:0.25NA CSA 4
    rs109177251,2
    C,F,A,H--163294334(+) AGATTG/ATCAGA 2 -- int130Minor allele frequency- A:0.38NS EA NA WA CSA 2815
    rs107999101,2
    C,F,A,H--163294528(+) TTTTTG/CTGGTT 2 -- int130Minor allele frequency- C:0.38NS EA NA WA CSA 2912

    HapMap Linkage Disequilibrium report for NUF2 (163236366 - 163325554 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for NUF2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv272989CNV Insertion20981092
    esv271740CNV Insertion20981092
    nsv160306CNV Loss16902084

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NUF2
    DNA2.0 Custom Variant and Variant Library Synthesis for NUF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611772    OMIM disorders: --

    11 diseases for NUF2:    About MalaCards
    duodenogastric reflux    pulmonary function    essential hypertension    sinusitis
    hypertension    choroiditis    schizophrenia    ovarian cancer
    lung cancer    breast cancer    cerebritis


    NUF2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NUF2
    Human Genome Epidemiology (HuGE) Navigator: NUF2 (2 documents)

    Export disorders for NUF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NUF2 gene, integrated from 10 sources (see all 50):
    (articles sorted by number of sources associating them with NUF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A conserved protein, Nuf2, is implicated in connecting the centromere to the spindle during chromosome segregation: a link between the kinetochore function and the spindle checkpoint. (PubMed id 11685532)1, 2, 3 Nabetani A.... Hiraoka Y. (Chromosoma 2001)
    2. The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation. (PubMed id 11266451)1, 2, 3 Wigge P.A. and Kilmartin J.V. (J. Cell Biol. 2001)
    3. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)
    4. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1, 4 Ehret G.B....Chakravarti A. (Eur. J. Hum. Genet. 2009)
    5. Human NUF2 interacts with centromere-associated protein E and is essential for a stable spindle microtubule-kinetochore attachment. (PubMed id 17535814)1, 2 Liu D.... Yao X. (J. Biol. Chem. 2007)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    7. Architecture of the human Ndc80-Hec1 complex, a critical constituent of the outer kinetochore. (PubMed id 15961401)1, 2 Ciferri C.... Musacchio A. (J. Biol. Chem. 2005)
    8. Hec1 and Nuf2 are core components of the kinetochore outer plate essential for organizing microtubule attachment sites. (PubMed id 15548592)1, 2 DeLuca J.G.... McEwen B.F. (Mol. Biol. Cell 2005)
    9. Kinetochore localization and microtubule interaction of the human spindle checkpoint kinase Mps1. (PubMed id 15235793)1, 2 Stucke V.M.... Nigg E.A. (Chromosoma 2004)
    10. Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model. (PubMed id 14602875)1, 2 Tien A.-C.... Huang C.-Y.F. (Mol. Cell. Proteomics 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 83540 HGNC: 14621 AceView: CDCA1 Ensembl:ENSG00000143228 euGenes: HUgn83540
    ECgene: NUF2 H-InvDB: NUF2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NUF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NUF2 gene:
    Search GeneIP for patents involving NUF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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