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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NUF2 Gene

protein-coding GIFtS: 56
GCID: GC01P163236

NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)

(Previous name: cell division cycle associated 1 )
(Previous symbol: CDCA1)

Explore 7 diseases affiliated with
NUF2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
NUF2, NDC80 Kinetochore Complex Component, Homolog (S. Cerevisiae)¹ ²		HNuf2¹
CDCA1¹ ² ³ ⁵		HNuf2R¹
NUF2R¹ ² ³ ⁵		HsNuf2¹
CT106¹ ²		Cancer/Testis Antigen 106²
Cell Division Cycle Associated 1¹ ²		Kinetochore Protein Nuf2²
Cell Division Cycle-Associated Protein 1² ³

External Ids:	HGNC: 14621¹	Entrez Gene: 83540²	Ensembl: ENSG00000143228⁷	OMIM: 611772⁵	UniProtKB: Q9BZD4³

Export aliases for NUF2 gene to outside databases

Previous GC identifers: GC01P161559 GC01P163291 GC01P134537

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NUF2:

This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated

with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their

connection to the spindle pole body, and plays a regulatory role in chromosome segregation. The encoded protein is

found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional

homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NUF2_HUMAN, Q9BZD4

Function: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome

segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable

microtubule binding sites in the outer plate of the kinetochore

Gene Wiki entry for NUF2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NUF2 gene promoter:
GR C/EBPbeta Sox5 FOXD3 POU6F1 (c2) LCR-F1 MEF-2A HFH-1 GR-alpha aMEF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NUF2 promoter sequence

Search SABiosciences Chromatin IP Primers for NUF2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUF2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.3 Ensembl cytogenetic band: 1q23.3 HGNC cytogenetic band: 1q23.3

NUF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUF2 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P163236: view genomic region (about GC identifiers)

Start:	163,236,366 bp from pter	End:	163,325,554 bp from pter
Size:	89,189 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NUF2_HUMAN, Q9BZD4 (See protein sequence)

Recommended Name: Kinetochore protein Nuf2

Size: 464 amino acids; 54304 Da

Subunit: Component of the NDC80 complex, which consists of NDC80/HEC1, CDCA1, SPBC24 and SPBC25. The NDC80 complex is

formed by two subcomplexes composed of NDC80/HEC1-CDCA1 and SPBC24-SPBC25. Each subcomplex is formed by parallel

interactions through the coiled-coil domains of individual subunits. Formation of a tetrameric complex is mediated by

interactions between the C-terminal regions of both subunits of the NDC80/HEC1-CDCA1 subcomplex and the N-terminal

regions of both subunits of the SPBC24-SPBC25 complex. The tetrameric NDC80 complex has an elongated rod-like

structure with globular domains at either end. May interact with AURKB/Aurora-B. Directly interacts with CENPE; this

interaction determines CENPE kinetochore localization

Subcellular location: Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase

to anaphase. Localizes specifically to the outer plate of the kinetochore. NDC80 is required for efficient kinetochore

localization

2 PDB 3D structures from and Proteopedia for NUF2:

2VE7 (3D)

3IZ0 (3D)

Secondary accessions: Q8WU69 Q96HJ4 Q96Q78

Explore the universe of human proteins at neXtProt for NUF2: NX_Q9BZD4

Post-translational modifications:

Can be phosphorylated by AURKA and AURKB¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BZD4

NUF2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_113611.2 NP_663735.2

ENSEMBL proteins:

ENSP00000433533 ENSP00000403252 ENSP00000436888 ENSP00000392652 ENSP00000356875

ENSP00000271452 ENSP00000436473

Reactome Protein details: Q9BZD4
Human Recombinant Protein Products for NUF2:

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	Uscn Proteins for NUF2

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000775	chromosome, centromeric region	NAS	11266451
GO:0000777	condensed chromosome kinetochore	IEA	--
GO:0005634	nucleus	IEA	--
GO:0005829	cytosol	TAS	--
GO:0031262	Ndc80 complex	IDA	14699129

NUF2 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for NUF2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NUF2 for domains About GeneDecksing

1 InterPro domain/family:

IPR005549 Kinetochore_Nuf2

Graphical View of Domain Structure for InterPro Entry Q9BZD4

ProtoNet protein and cluster: Q9BZD4

UniProtKB/Swiss-Prot: NUF2_HUMAN, Q9BZD4

Similarity: Belongs to the NUF2 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: NUF2_HUMAN, Q9BZD4

Function: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome

segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable

microtubule binding sites in the outer plate of the kinetochore

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0005515	protein binding	IPI	--

NUF2 for ontologies About GeneDecksing

Phenotypes:
10 GenomeRNAi human phenotypes for NUF2:

Abundance of large cells with	Cell cycle / mitosis defect	Decreased Hepatitis C virus re	Decreased viability of wild-ty
Increased S DNA content	Increased Salmonella enterica	Increased Salmonella enterica	Increased gamma-H2AX phosphory
Increased number of cells in m	Increased number of mitotic ce

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NUF2

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUF2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

M Phase

M Phase	1.00	Mitotic Anaphase	0.85
Mitotic M-M/G1 phases	0.88	Separation of Sister Chromatids	0.80
Mitotic Metaphase and Anaphase	0.85

Resolution of Sister Chromatid Cohesion

	Resolution of Sister Chromatid Cohesion	1.00			Mitotic Prometaphase	0.93
	Kinetochore assembly	0.96

Cell Cycle

Cell Cycle

1.00

Cell Cycle, Mitotic

0.84

Pathway sources
See GeneCards unified pathways
Show all pathways

5/10 Reactome Pathways for NUF2 (see all 10)

	Mitotic Metaphase and Anaphase
	Mitotic Prometaphase
	Resolution of Sister Chromatid Cohesion
	Mitotic Anaphase
	Cell Cycle

NUF2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NUF2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/807 Interacting proteins for NUF2 (Q9BZD4^{1, 2, 3} ENSP00000271452⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 807)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NDC80	O14777¹^,²^,³, ENSP00000261597⁴	EBI-724102,EBI-715849 MINT-7945693 MINT-7947479 I2D: score=4 STRING: ENSP00000261597
BUB1	O43683²^,³, ENSP00000302530⁴	MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000302530
CENPE	Q02224¹^,³, ENSP00000265148⁴	EBI-724102,EBI-1375040 I2D: score=2 STRING: ENSP00000265148
EXOC1	Q9NV70²^,³, ENSP00000326514⁴	MINT-7945693 I2D: score=2 STRING: ENSP00000326514
AURKB	Q96GD4²^,³, ENSP00000313950⁴	MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000313950

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000087	M phase of mitotic cell cycle	TAS	--
GO:0000236	mitotic prometaphase	TAS	--
GO:0000278	mitotic cell cycle	TAS	--
GO:0007059	chromosome segregation	NAS	11266451
GO:0007067	mitosis	--	--

NUF2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NUF2
Search CenterWatch for drugs/clinical trials and news about NUF2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NUF2 gene (2 alternative transcripts):

NM_031423.3 NM_145697.2

Unigene Cluster for NUF2:

NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)

Hs.651950 [show with all ESTs]

Unigene Representative Sequence: NM_145697

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000534289 ENST00000450453 ENST00000524800 ENST00000442820 ENST00000367900(uc001gcr.1)

ENST00000271452(uc001gcq.1) ENST00000490881 ENST00000487578 ENST00000497990

ENST00000527439 ENST00000527120 ENST00000531529

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Additional cDNA sequence:

AB050577.1 AB050578.1 AF326731.1 AK093348.1 BC008489.1 BC021171.2

15 DOTS entries:

DT.91717067 DT.100818709 DT.95272793 DT.95272795 DT.410980 DT.100818708 DT.121444525 DT.100842852

DT.121444490 DT.40118894 DT.75186952 DT.95272794 DT.95272796 DT.95272798 DT.99966185

24/108 AceView cDNA sequences (see all 108):

BC008489 AI015982 BG354574 BE882537 BG119621 AA764964 BU622548 AW662200

AA383719 AW130102 AB050578 CA428550 BU521688 BX443441 AI038782 AW001937

AL531815 AK093348 BX283986 AI081570 AW197999 AX748068 CR619637 AW239243

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for NUF2 (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16
SP1:											-								-																						-
SP2:									-		-								-																						-
SP3:									-										-
SP4:																			-
SP5:											-

ECgene alternative splicing isoforms for NUF2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NUF2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTCTACTCT

About this image

NUF2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

S-shaped Body

Kidney Endothelial Cells

Endothelium

Reproductive System

Kidney

Reproductive System

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Adult human kidney epithelial cells (Primary Cell)

Kidney

See NUF2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NUF2

SOURCE GeneReport for Unigene cluster: Hs.651950

SABiosciences Custom PCR Arrays for NUF2

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUF2 gene from 9/26 species (see all 26) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Nuf2^{1 , 5}	NUF2, NDC80 kinetochore complex component, homolog more^{1, 5}	79.8(n)¹ 73.38(a)¹		1 (76.84 cM)⁵ 66977¹ NM_023284.3¹ NP_075773.2¹ 169497934⁵
chicken (Gallus gallus)	Aves	NUF2¹	NUF2, NDC80 kinetochore complex component, homolog more	66.59(n) 58.41(a)		395135 NM_204478.2 NP_989809.2
lizard (Anolis carolinensis)	Reptilia	NUF2⁶	--	46(a)	1 ↔ 1	GL343405.1(332867-362014)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.4392²	Transcribed sequence with weak similarity to protein more	70.4(n)		142034571
zebrafish (Danio rerio)	Actinopterygii	nuf2¹	NUF2, NDC80 kinetochore complex component, homolog	47.34(n) 34.38(a)		393280 NM_200310.1 NP_956604.1
worm (Caenorhabditis elegans)	Secernentea	him-10⁶	Kinetochore protein Nuf2 homolog	14(a)	1 ↔ 1	III(5803215-5805205)
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	NUF2¹	Nuf2p	42.42(n) 25.5(a)		854085 NP_014572.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G61000⁶	kinetochore protein Nuf2	14(a)	1 ↔ 1	1(22470924-22474105)
rice (Oryza sativa)	Liliopsida	-- --	nuf2 family protein, expressed	18(a) 18(a)	many → 1 many → 1	3(21100638-21104522) 8(3721368-3725249)

ENSEMBL Gene Tree for NUF2 (if available)
TreeFam Gene Tree for NUF2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs59016968^1,2	C	--	163293628(+)	`CAACAA/GGAACA`	2	--	int¹		2		WA	120
rs11455569^1,2	C	--	163293777(+)	`CCATT-/AATACT`	2	--	int¹		0	--	--	--	--
rs201867117^1,2	C	--	163293777(+)	`GCCATA/TATACT`	2	--	int¹		0	--	--	--	--
rs11376676^1,2	C	--	163293778(+)	`CATTAA/-TACTG`	2	--	int¹		1		NA	2
rs76393624^1,2	F	--	163293909(+)	`GTCATA/GTAAGG`	2	--	int¹		2		WA EA	238
rs10587855^1,2	C	--	163294033(+)	`TAAAC-/AGAGATT`	2	--	int¹		0	--	--	--	--
rs61812214^1,2		--	163294198(+)	`ACATGT/ATCAAG`	2	--	int¹		2		NA	122
rs192839054^1,2		--	163294225(+)	`TTTGTA/TAGTGG`	2	--	int¹		0	--	--	--	--
rs34585024^1,2	C	--	163294303(+)	`ATTCT-/AAAAAA`	2	--	int¹		1		CSA	2
rs11421867^1,2	C	--	163294304(+)	`AAAAAA/-TTAGG`	2	--	int¹		1		NA	2

HapMap Linkage Disequilibrium report for NUF2 (163236366 - 163325554 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for NUF2
1 CNV: 5531

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NUF2 for disorders           About GeneDecksing

OMIM gene information: 611772    OMIM disorders: --

7 diseases for NUF2:    About MalaCards

duodenogastric reflux essential hypertension hypertension gastric cancer

lung cancer breast cancer schizophrenia

Human Genome Epidemiology (HuGE) Navigator: NUF2 (2 documents)

Export disorders for NUF2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for NUF2 gene, integrated from 9 sources (see all 41):
(articles sorted by number of sources associating them with NUF2)

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A conserved protein, Nuf2, is implicated in connecting the centromere to the spindle during chromosome segregation: a link between the kinetochore function and the spindle checkpoint. (PubMed id 11685532)^{1, 2, 3} Nabetani A.... Hiraoka Y. (2001)
The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation. (PubMed id 11266451)^{1, 2, 3} Wigge P.A. and Kilmartin J.V. (2001)
Human NUF2 interacts with centromere-associated protein E and is essential for a stable spindle microtubule-kinetochore attachment. (PubMed id 17535814)^{1, 2} Liu D....Yao X. (2007)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
Architecture of the human Ndc80-Hec1 complex, a critical constituent of the outer kinetochore. (PubMed id 15961401)^{1, 2} Ciferri C.... Musacchio A. (2005)
Hec1 and Nuf2 are core components of the kinetochore outer plate essential for organizing microtubule attachment sites. (PubMed id 15548592)^{1, 2} DeLuca J.G.... McEwen B.F. (2005)
Kinetochore localization and microtubule interaction of the human spindle checkpoint kinase Mps1. (PubMed id 15235793)^{1, 2} Stucke V.M.... Nigg E.A. (2004)
Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model. (PubMed id 14602875)^{1, 2} Tien A.-C.... Huang C.-Y.F. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Identification of two novel components of the human NDC80 kinetochore complex. (PubMed id 14699129)^{1, 2} Bharadwaj R.... Yu H. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 83540	HGNC: 14621	AceView: CDCA1	Ensembl:ENSG00000143228	euGenes: HUgn83540
ECgene: NUF2	H-InvDB: NUF2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NUF2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NUF2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NUF2 gene:
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NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)

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NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)

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