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Aliases for NUF2 Gene

Aliases for NUF2 Gene

  • NUF2, NDC80 Kinetochore Complex Component 2 3 5
  • Cell Division Cycle-Associated Protein 1 3 4
  • Cell Division Cycle Associated 1 2 3
  • Cancer/Testis Antigen 106 2 3
  • HNuf2R 3 4
  • HsNuf2 3 4
  • CDCA1 3 4
  • NUF2R 3 4
  • HNuf2 3 4
  • NUF2, NDC80 Kinetochore Complex Component, Homolog (S. Cerevisiae) 2
  • NUF2, NDC80 Kinetochore Complex Component, Homolog 3
  • Kinetochore Protein Nuf2 3
  • CT106 3

External Ids for NUF2 Gene

Previous HGNC Symbols for NUF2 Gene

  • CDCA1

Previous GeneCards Identifiers for NUF2 Gene

  • GC01P161559
  • GC01P163291
  • GC01P134537

Summaries for NUF2 Gene

Entrez Gene Summary for NUF2 Gene

  • This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation. The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for NUF2 Gene

NUF2 (NUF2, NDC80 Kinetochore Complex Component) is a Protein Coding gene. Among its related pathways are Mitotic Metaphase and Anaphase and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for NUF2 Gene

  • Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12438418, PubMed:14654001, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:17535814). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).

Gene Wiki entry for NUF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUF2 Gene

Genomics for NUF2 Gene

Regulatory Elements for NUF2 Gene

Enhancers for NUF2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F163320 1.2 ENCODE 19 +55.6 55584 3.1 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF263 SP3 ENSG00000272574 NUF2 UAP1 RGS4 LOC101928404 ENSG00000232995 LOC100422212
GH01F163195 1 Ensembl ENCODE 10.4 -70.1 -70055 1.8 HDAC1 JUN ZMYM3 RAD21 CCNT2 GATA2 NFE2 MAFK TCF7L2 ARID1B LOC101928404 RGS5 NUF2 ENSG00000232995 LOC100113374
GH01F163307 0.5 ENCODE 11.1 +41.2 41205 1.4 ZNF664 JUND FOS ENSG00000232995 NUF2 RGS4 GC01P163316 PIR46310
GH01F163231 0.4 ENCODE 11.4 -34.9 -34866 0.9 JUND NUF2 RGS4 ENSG00000232995 LOC100113374 LOC101928404
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NUF2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NUF2 Gene

Chromosome:
1
Start:
163,266,576 bp from pter
End:
163,355,764 bp from pter
Size:
89,189 bases
Orientation:
Plus strand

Genomic View for NUF2 Gene

Genes around NUF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUF2 Gene

Proteins for NUF2 Gene

  • Protein details for NUF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZD4-NUF2_HUMAN
    Recommended name:
    Kinetochore protein Nuf2
    Protein Accession:
    Q9BZD4
    Secondary Accessions:
    • Q8WU69
    • Q96HJ4
    • Q96Q78

    Protein attributes for NUF2 Gene

    Size:
    464 amino acids
    Molecular mass:
    54304 Da
    Quaternary structure:
    • Component of the NDC80 complex, which consists of NDC80/HEC1, CDCA1, SPBC24 and SPBC25. The NDC80 complex is formed by two subcomplexes composed of NDC80/HEC1-CDCA1 and SPBC24-SPBC25. Each subcomplex is formed by parallel interactions through the coiled-coil domains of individual subunits. Formation of a tetrameric complex is mediated by interactions between the C-terminal regions of both subunits of the NDC80/HEC1-CDCA1 subcomplex and the N-terminal regions of both subunits of the SPBC24-SPBC25 complex. The tetrameric NDC80 complex has an elongated rod-like structure with globular domains at either end. May interact with AURKB/Aurora-B. Directly interacts with CENPE; this interaction determines CENPE kinetochore localization.

    Three dimensional structures from OCA and Proteopedia for NUF2 Gene

neXtProt entry for NUF2 Gene

Post-translational modifications for NUF2 Gene

  • Can be phosphorylated by AURKA and AURKB.
  • Ubiquitination at Lys 299, Lys 383, Lys 402, and Lys 418
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NUF2 Gene

Domains & Families for NUF2 Gene

Protein Domains for NUF2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NUF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BZD4

UniProtKB/Swiss-Prot:

NUF2_HUMAN :
  • Belongs to the NUF2 family.
Family:
  • Belongs to the NUF2 family.
genes like me logo Genes that share domains with NUF2: view

No data available for Gene Families for NUF2 Gene

Function for NUF2 Gene

Molecular function for NUF2 Gene

UniProtKB/Swiss-Prot Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12438418, PubMed:14654001, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:17535814). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).

Gene Ontology (GO) - Molecular Function for NUF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 14699129
genes like me logo Genes that share ontologies with NUF2: view
genes like me logo Genes that share phenotypes with NUF2: view

Animal Model Products

miRNA for NUF2 Gene

miRTarBase miRNAs that target NUF2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NUF2

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUF2 Gene

Localization for NUF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUF2 Gene

Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore. NDC80 is required for efficient kinetochore localization.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUF2 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for NUF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region NAS 11266451
GO:0000776 kinetochore IEA --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus IDA --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with NUF2: view

Pathways & Interactions for NUF2 Gene

genes like me logo Genes that share pathways with NUF2: view

Pathways by source for NUF2 Gene

Gene Ontology (GO) - Biological Process for NUF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007059 chromosome segregation NAS 11266451
GO:0007062 sister chromatid cohesion TAS --
GO:0007067 mitotic nuclear division IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with NUF2: view

No data available for SIGNOR curated interactions for NUF2 Gene

Transcripts for NUF2 Gene

Unigene Clusters for NUF2 Gene

NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NUF2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUF2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - -
SP2: - - - -
SP3: - -
SP4: -
SP5: -
SP6:

Relevant External Links for NUF2 Gene

GeneLoc Exon Structure for
NUF2
ECgene alternative splicing isoforms for
NUF2

Expression for NUF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NUF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NUF2 Gene

This gene is overexpressed in Testis (x12.7).

Protein differential expression in normal tissues from HIPED for NUF2 Gene

This gene is overexpressed in Breast (47.6), Bone (10.5), and Plasma (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NUF2 Gene



Protein tissue co-expression partners for NUF2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NUF2 Gene:

NUF2

SOURCE GeneReport for Unigene cluster for NUF2 Gene:

Hs.651950
genes like me logo Genes that share expression patterns with NUF2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for NUF2 Gene

Orthologs for NUF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NUF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUF2 34 35
  • 99.35 (n)
cow
(Bos Taurus)
Mammalia NUF2 34 35
  • 92.12 (n)
dog
(Canis familiaris)
Mammalia NUF2 34 35
  • 90.45 (n)
rat
(Rattus norvegicus)
Mammalia Nuf2 34
  • 81.6 (n)
mouse
(Mus musculus)
Mammalia Nuf2 34 16 35
  • 79.8 (n)
oppossum
(Monodelphis domestica)
Mammalia NUF2 35
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUF2 35
  • 40 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUF2 34 35
  • 66.59 (n)
lizard
(Anolis carolinensis)
Reptilia NUF2 35
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nuf2 34
  • 57.95 (n)
Str.4392 34
zebrafish
(Danio rerio)
Actinopterygii nuf2 34 35
  • 47.54 (n)
Species where no ortholog for NUF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUF2 Gene

ENSEMBL:
Gene Tree for NUF2 (if available)
TreeFam:
Gene Tree for NUF2 (if available)

Paralogs for NUF2 Gene

No data available for Paralogs for NUF2 Gene

Variants for NUF2 Gene

Sequence variations from dbSNP and Humsavar for NUF2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10158552 -- 163,346,101(+) TTAGG(A/G)GATTC intron-variant
rs1022058 -- 163,340,720(+) TGATA(C/T)TAGGC intron-variant
rs1022059 -- 163,340,761(+) TTAGC(A/G)ATATA intron-variant
rs10449259 -- 163,354,717(+) TCTAA(A/G)AGAAG intron-variant
rs1047134 -- 163,328,757(+) AATCT(C/T)TTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUF2 Gene

Variant ID Type Subtype PubMed ID
nsv160306 CNV deletion 16902084

Variation tolerance for NUF2 Gene

Residual Variation Intolerance Score: 38% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.00; 80.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUF2 Gene

Disorders for NUF2 Gene

Relevant External Links for NUF2

Genetic Association Database (GAD)
NUF2
Human Genome Epidemiology (HuGE) Navigator
NUF2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUF2

No disorders were found for NUF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUF2 Gene

Publications for NUF2 Gene

  1. The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation. (PMID: 11266451) Wigge P.A. … Kilmartin J.V. (J. Cell Biol. 2001) 2 3 4 64
  2. A conserved protein, Nuf2, is implicated in connecting the centromere to the spindle during chromosome segregation: a link between the kinetochore function and the spindle checkpoint. (PMID: 11685532) Nabetani A. … Hiraoka Y. (Chromosoma 2001) 2 3 4 64
  3. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson J.E. … Couch F.J. (Breast Cancer Res. Treat. 2011) 3 46 64
  4. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret G.B. … Chakravarti A. (Eur. J. Hum. Genet. 2009) 3 46 64
  5. Human NUF2 interacts with centromere-associated protein E and is essential for a stable spindle microtubule-kinetochore attachment. (PMID: 17535814) Liu D. … Yao X. (J. Biol. Chem. 2007) 3 4 64

Products for NUF2 Gene

Sources for NUF2 Gene

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