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Aliases for NUF2 Gene

Aliases for NUF2 Gene

  • NUF2, NDC80 Kinetochore Complex Component 2 3
  • CDCA1 3 4 6
  • NUF2R 3 4 6
  • Cell Division Cycle-Associated Protein 1 3 4
  • Cell Division Cycle Associated 1 2 3
  • Cancer/Testis Antigen 106 2 3
  • HNuf2R 3 4
  • HsNuf2 3 4
  • HNuf2 3 4
  • NUF2, NDC80 Kinetochore Complex Component, Homolog (S. Cerevisiae) 2
  • NUF2, NDC80 Kinetochore Complex Component, Homolog 3
  • Kinetochore Protein Nuf2 3
  • CT106 3

External Ids for NUF2 Gene

Previous HGNC Symbols for NUF2 Gene

  • CDCA1

Previous GeneCards Identifiers for NUF2 Gene

  • GC01P161559
  • GC01P163291
  • GC01P134537

Summaries for NUF2 Gene

Entrez Gene Summary for NUF2 Gene

  • This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation. The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for NUF2 Gene

NUF2 (NUF2, NDC80 Kinetochore Complex Component) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for NUF2 Gene

  • Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore.

Gene Wiki entry for NUF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUF2 Gene

Genomics for NUF2 Gene

Regulatory Elements for NUF2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NUF2 Gene

Start:
163,266,576 bp from pter
End:
163,355,764 bp from pter
Size:
89,189 bases
Orientation:
Plus strand

Genomic View for NUF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUF2 Gene

Proteins for NUF2 Gene

  • Protein details for NUF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZD4-NUF2_HUMAN
    Recommended name:
    Kinetochore protein Nuf2
    Protein Accession:
    Q9BZD4
    Secondary Accessions:
    • Q8WU69
    • Q96HJ4
    • Q96Q78

    Protein attributes for NUF2 Gene

    Size:
    464 amino acids
    Molecular mass:
    54304 Da
    Quaternary structure:
    • Component of the NDC80 complex, which consists of NDC80/HEC1, CDCA1, SPBC24 and SPBC25. The NDC80 complex is formed by two subcomplexes composed of NDC80/HEC1-CDCA1 and SPBC24-SPBC25. Each subcomplex is formed by parallel interactions through the coiled-coil domains of individual subunits. Formation of a tetrameric complex is mediated by interactions between the C-terminal regions of both subunits of the NDC80/HEC1-CDCA1 subcomplex and the N-terminal regions of both subunits of the SPBC24-SPBC25 complex. The tetrameric NDC80 complex has an elongated rod-like structure with globular domains at either end. May interact with AURKB/Aurora-B. Directly interacts with CENPE; this interaction determines CENPE kinetochore localization.

    Three dimensional structures from OCA and Proteopedia for NUF2 Gene

neXtProt entry for NUF2 Gene

Proteomics data for NUF2 Gene at MOPED

Post-translational modifications for NUF2 Gene

  • Can be phosphorylated by AURKA and AURKB.
  • Ubiquitination at Lys299, Lys383, Lys402, and Lys418
  • Modification sites at PhosphoSitePlus

Other Protein References for NUF2 Gene

No data available for DME Specific Peptides for NUF2 Gene

Domains for NUF2 Gene

Protein Domains for NUF2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NUF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BZD4

UniProtKB/Swiss-Prot:

NUF2_HUMAN :
  • Q9BZD4
Family:
  • Belongs to the NUF2 family.
genes like me logo Genes that share domains with NUF2: view

No data available for Gene Families for NUF2 Gene

Function for NUF2 Gene

Molecular function for NUF2 Gene

UniProtKB/Swiss-Prot Function: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore.

Gene Ontology (GO) - Molecular Function for NUF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 14699129
genes like me logo Genes that share ontologies with NUF2: view
genes like me logo Genes that share phenotypes with NUF2: view

Animal Model Products

CRISPR Products

miRNA for NUF2 Gene

miRTarBase miRNAs that target NUF2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NUF2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NUF2 Gene

Localization for NUF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUF2 Gene

Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore. NDC80 is required for efficient kinetochore localization.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUF2 Gene COMPARTMENTS Subcellular localization image for NUF2 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for NUF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region NAS 11266451
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with NUF2: view

Pathways for NUF2 Gene

genes like me logo Genes that share pathways with NUF2: view

Pathways by source for NUF2 Gene

Gene Ontology (GO) - Biological Process for NUF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0007059 chromosome segregation NAS 11266451
GO:0007067 mitotic nuclear division IEA --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with NUF2: view

Transcripts for NUF2 Gene

Unigene Clusters for NUF2 Gene

NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NUF2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NUF2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUF2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - -
SP2: - - - -
SP3: - -
SP4: -
SP5: -
SP6:

Relevant External Links for NUF2 Gene

GeneLoc Exon Structure for
NUF2
ECgene alternative splicing isoforms for
NUF2

Expression for NUF2 Gene

mRNA expression in normal human tissues for NUF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NUF2 Gene

This gene is overexpressed in Testis (12.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUF2 Gene

SOURCE GeneReport for Unigene cluster for NUF2 Gene Hs.651950

genes like me logo Genes that share expressions with NUF2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NUF2 Gene

Orthologs for NUF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NUF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUF2 35
  • 99.35 (n)
  • 100 (a)
NUF2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NUF2 35
  • 92.12 (n)
  • 91.54 (a)
NUF2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUF2 35
  • 90.45 (n)
  • 89.22 (a)
NUF2 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nuf2 35
  • 79.8 (n)
  • 73.38 (a)
Nuf2 16
Nuf2 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NUF2 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUF2 36
  • 40 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nuf2 35
  • 81.6 (n)
  • 79.44 (a)
chicken
(Gallus gallus)
Aves NUF2 35
  • 66.59 (n)
  • 58.41 (a)
NUF2 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUF2 36
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nuf2 35
  • 57.95 (n)
  • 44.88 (a)
Str.4392 35
zebrafish
(Danio rerio)
Actinopterygii nuf2 35
  • 47.54 (n)
  • 34.79 (a)
nuf2 36
  • 33 (a)
OneToOne
Species with no ortholog for NUF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUF2 Gene

ENSEMBL:
Gene Tree for NUF2 (if available)
TreeFam:
Gene Tree for NUF2 (if available)

Paralogs for NUF2 Gene

No data available for Paralogs for NUF2 Gene

Variants for NUF2 Gene

Sequence variations from dbSNP and Humsavar for NUF2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1022058 -- 163,340,720(+) TGATA(C/T)TAGGC intron-variant
rs1022059 -- 163,340,761(+) TTAGC(A/G)ATATA intron-variant
rs1047134 -- 163,328,757(+) AATCT(C/T)TTTCT intron-variant
rs1509022 -- 163,339,429(+) GATGG(A/T)ATTCA reference, synonymous-codon
rs1509023 -- 163,339,843(+) TGTCA(C/T)ATCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUF2 Gene

Variant ID Type Subtype PubMed ID
nsv160306 CNV Loss 16902084
esv271740 CNV Insertion 20981092
esv272989 CNV Insertion 20981092

Relevant External Links for NUF2 Gene

HapMap Linkage Disequilibrium report
NUF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUF2 Gene

Disorders for NUF2 Gene

Relevant External Links for NUF2

Genetic Association Database (GAD)
NUF2
Human Genome Epidemiology (HuGE) Navigator
NUF2
genes like me logo Genes that share disorders with NUF2: view

No data available for UniProtKB/Swiss-Prot for NUF2 Gene

Publications for NUF2 Gene

  1. The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation. (PMID: 11266451) Wigge P.A. … Kilmartin J.V. (J. Cell Biol. 2001) 2 3 4
  2. A conserved protein, Nuf2, is implicated in connecting the centromere to the spindle during chromosome segregation: a link between the kinetochore function and the spindle checkpoint. (PMID: 11685532) Nabetani A. … Hiraoka Y. (Chromosoma 2001) 2 3 4
  3. hNuf2 inhibition blocks stable kinetochore-microtubule attachment and induces mitotic cell death in HeLa cells. (PMID: 12438418) DeLuca J.G. … Salmon E.D. (J. Cell Biol. 2002) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Hec1 and Nuf2 are core components of the kinetochore outer plate essential for organizing microtubule attachment sites. (PMID: 15548592) DeLuca J.G. … McEwen B.F. (Mol. Biol. Cell 2005) 3 4

Products for NUF2 Gene

Sources for NUF2 Gene

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