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Aliases & Descriptions for NUDT9
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases ADPR-PPase 3 EC 3.6.1.13 3 MGC3037 1 , 2 NUDT10 2 , 3
Descriptions ADP-ribose diphosphatase 2 , 3 ADP-ribose phosphohydrolase 2 , 3 ADP-ribose pyrosphosphatase NUDT9 2 Adenosine diphosphoribose pyrophosphatase 2 , 3 Nucleoside diphosphate-linked moiety X motif 9 3 Nudix motif 9 3 nucleoside diphosphate linked moiety X-type motif 9 2 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2 nudix-type motif 9 2
Search outside databases for aliases for NUDT9 genePrevious GC identifers: GC04P088501 GC04P088802 GC04P088700
Summaries for NUDT9 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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UniProtKB/Swiss-Prot: NUDT9_HUMAN, Q9BW91 Function : Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate
Gene Wiki entry for NUDT9
Genomic Location for NUDT9
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the NUDT9 gene Entrez Gene cytogenetic band: 4q22.1 Ensembl cytogenetic band: 4q22.1 HGNC cytogenetic band: 4q22.1 NUDT9 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04P088645:
(about GC identifiers )
Start:
88,562,759 bp from pter
End:
88,598,523 bp from pter
Size:
35,765 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000004.10 NT_016354.18 Proteins for NUDT9
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: NUDT9_HUMAN, Q9BW91 (See
protein sequence )Recommended Name: ADP-ribose pyrophosphatase, mitochondrial precursor Size : 350 amino acids; 39125 Da
Cofactor : Magnesium
Cofactor : Manganese
Subunit : Monomer. Interacts with C17orf25
Subcellular location : Isoform 1: Mitochondrion
PDB structure from and Proteopedia : 1Q33 (3D)
 1QVJ (3D)
 
Secondary accessions : Q8NBN1 Q8NCB9 Q8NG25Alternative splicing : 2 isoforms : Q9BW91-1 Q9BW91-2
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_076952.1 NP_932155.1 ENSEMBL proteins: ENSP00000350728 ENSP00000303575 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: NUDT9 2 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for NUDT9: Assays for NUDT9:
Protein
Domains/ Families for NUDT9(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9BW91 ProtoNet protein and cluster: Q9BW91
1 Blocks protein family : IPB000086 NUDIX hydrolase UniProtKB/Swiss-Prot: NUDT9_HUMAN, Q9BW91 Similarity : Belongs to the Nudix hydrolase family. NudF subfamily
Gene Function for NUDT9
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
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SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_198038 Applied Biosystems Silencer ® siRNAs for NUDT9 Sigma-Aldrich siRNA for NUDT9 Sigma-Aldrich shRNA for NUDT9 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_024047                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_024047                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_024047  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_024047 UniProtKB/Swiss-Prot: NUDT9_HUMAN, Q9BW91 Function : Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphateCatalytic activity : ADP-ribose + H(2)O = AMP + D-ribose 5-phosphateInduction : Isoform 1 is inhibited by fluoride and N-acetyl-p-benzoquinoneimineEnzyme Number (IUBMB): EC 3.6.1.13
1 MGI phenotypic allele for Nudt9 (no phenotypes)5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6
):
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Pathways & Interactions for NUDT9
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for NUDT9 (Your Favorite Gene powered by Ingenuity) 5/7 Interacting proteins for NUDT9 (ENSP00000303575 3 ) via UniProtKB, MINT, and/or STRING (see all 7
)About this table 3 Gene Ontology (GO) biological process terms (links to tree view) :
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Drugs & Compounds for NUDT9 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
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Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Transcripts for NUDT9(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
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shRNA from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_198038 Sigma-Aldrich siRNA for NUDT9 Sigma-Aldrich shRNA for NUDT9 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_024047 NM_198038
REFSEQ mRNAs for NUDT9 gene (2 alternative transcripts): NM_024047.3 NM_198038.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_024047 NM_198038
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_024047                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_024047                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_024047  
Additional cDNA sequence: AF265341.1 AF273028.1 AK027295.1 AK075408.1 AK308028.1 AY026252.1 AY359123.1 BC000542.2 CR597296.1 CR604538.1 CR619203.1 CR620878.1 CR626425.1
13 DOTS entries : DT.315308 DT.92045022 DT.100841614 DT.100027645 DT.100819331 DT.92426610 DT.100027640 DT.121234885 DT.315309 DT.100819324 DT.121234852 DT.92426611 DT.95170258
24/240 AceView cDNA sequences (see all 240
):BQ876864 AI522180 AI376380 AI262640 CR619203 AI473262 BI836200 BM825595 AW067801 BQ003544 BM769664 CB960100 CF552699 BQ130633 BX113602 NM_198039 BE313464 AK074845 CD243190 AI473395 BF589881 BM818963 BQ020812 CR604538
highest scoring ESTs for NUDT9 :AW000891 AA151649 AA317639 AA449304 AA478767 AA526157 AA558703 AA640299 AA643644 AA644080
Unigene Cluster for NUDT9: Nudix (nucleoside diphosphate linked moiety X)-type motif 9 Hs.149500 [show with all ESTs ] Unigene Representative Sequence: BM923755 GeneLoc Exon Structure 5/9 Alternative Splicing Database (ASD) splice patterns (SP) for NUDT9 (see all 9
) ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 SP1 :               -             -   -               SP2 :         -   -   -   -             -   -               SP3 :       -   -   -   -   -             -   -               SP4 :                                           SP5 :                                          
About this scheme ECgene alternative splicing isoforms for NUDT9 2 Ensembl transcripts including schematic representations : ENST00000358033
ENST00000302174
Expression for NUDT9
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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NUDT9 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for NUDT9 1 / 2 / 3
3 probe-sets matching NUDT9 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GCTTAAATTASOURCE GeneReport for Unigene cluster: Hs.149500 UniProtKB/Swiss-Prot: NUDT9_HUMAN, Q9BW91 Tissue specificity : Ubiquitously expressed but isoform 1 is the most predominant isoform
Orthologs for NUDT9
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for NUDT9 gene from 5/12 species (see all 12
)
About this table Species with no ortholog for NUDT9 ENSEMBL Gene Tree for NUDT9 Paralogs for NUDT9 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Pseudogenes 1 related pseudogene
SNPs/Variants for NUDT9 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for NUDT9 (up to first 250kb)
Disorders & Mutations for NUDT9
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 606022
Medical News for NUDT9 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for NUDT9 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/15 PubMed articles for NUDT9 gene (see all 15
): NUDT9, a member of the Nudix hydrolase family, is an evolutionarily conserved mitochondrial ADP-ribose pyrophosphatase. (PubMed id 12427752) 1, 2, 3, 4 Perraud A.L....Scharenberg A.M. (2003) ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. (PubMed id 11385575) 2, 3, 4 Perraud A.L....Scharenberg A.M. (2001) Interaction of C17orf25 with ADP-ribose pyrophosphatase NUDT9 detected via yeast two-hybrid method. (PubMed id 12897971) 1, 3, 4 Zhang H.-T.... Gong Y. (2003) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3, 4 Ota T....Sugano S. (2004) The crystal structure and mutational analysis of human NUDT9. (PubMed id 12948489) 3, 4 Shen B.W.... Stoddard B.L. (2003) The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309) 3, 4 Clark H.F....Gray A. (2003) Cloning, expression and characterisation of a human Nudix hydrolase specific for adenosine 5'-diphosphoribose (ADP-ribose). (PubMed id 11825615) 3, 4 Lin S.... McLennan A.G. (2002) The specific, submicromolar-Km ADP-ribose pyrophosphatase purified from human placenta is enzymically indistinguishable from recombinant NUDT9 protein, including a selectivity for Mn2+ as activating cation and increase in Km for ADP-ribose, both elicited by H2O2. (PubMed id 16860484) 1, 3 Carloto A....Ribeiro J.M. (2006) A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648) 4 Dephoure N.... Gygi S.P. (2008)
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Genome Databases showing NUDT9
(According to
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AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
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Other Databases showing NUDT9
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Specialized Databases showing NUDT9 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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