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Aliases for NUDT9 Gene

Aliases for NUDT9 Gene

  • Nudix Hydrolase 9 2 3 5
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 9 2 3
  • Adenosine Diphosphoribose Pyrophosphatase 3 4
  • ADP-Ribose Phosphohydrolase 3 4
  • ADP-Ribose Diphosphatase 3 4
  • ADPR-PPase 3 4
  • NUDT10 3 4
  • Nucleoside Diphosphate Linked Moiety X-Type Motif 9 3
  • Nucleoside Diphosphate-Linked Moiety X Motif 9 4
  • ADP-Ribose Pyrosphosphatase NUDT9 3
  • Nudix Motif 9 4
  • EC 3.6.1.13 4

External Ids for NUDT9 Gene

Previous GeneCards Identifiers for NUDT9 Gene

  • GC04P088501
  • GC04P088645
  • GC04P088802
  • GC04P088700
  • GC04P088343
  • GC04P084089

Summaries for NUDT9 Gene

Entrez Gene Summary for NUDT9 Gene

  • The protein encoded by this gene belongs to the Nudix hydrolase family. Nudix boxes are found in a family of diverse enzymes that catalyze the hydrolysis of nucleoside diphosphate derivatives. This enzyme is an ADP-ribose pyrophosphatase that catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. It requires divalent metal ions and an intact Nudix motif for enzymatic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for NUDT9 Gene

NUDT9 (Nudix Hydrolase 9) is a Protein Coding gene. Among its related pathways are Pyrimidine metabolism (KEGG) and Metabolism. GO annotations related to this gene include hydrolase activity and ADP-sugar diphosphatase activity.

UniProtKB/Swiss-Prot for NUDT9 Gene

  • Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5-phosphate.

Gene Wiki entry for NUDT9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT9 Gene

Genomics for NUDT9 Gene

Regulatory Elements for NUDT9 Gene

Enhancers for NUDT9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NUDT9 on UCSC Golden Path with GeneCards custom track

Promoters for NUDT9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NUDT9 on UCSC Golden Path with GeneCards custom track

Genomic Location for NUDT9 Gene

Chromosome:
4
Start:
87,422,557 bp from pter
End:
87,459,454 bp from pter
Size:
36,898 bases
Orientation:
Plus strand

Genomic View for NUDT9 Gene

Genes around NUDT9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDT9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDT9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT9 Gene

Proteins for NUDT9 Gene

  • Protein details for NUDT9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BW91-NUDT9_HUMAN
    Recommended name:
    ADP-ribose pyrophosphatase, mitochondrial
    Protein Accession:
    Q9BW91
    Secondary Accessions:
    • Q8NBN1
    • Q8NCB9
    • Q8NG25

    Protein attributes for NUDT9 Gene

    Size:
    350 amino acids
    Molecular mass:
    39125 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Monomer. Interacts with GLOD4.

    Three dimensional structures from OCA and Proteopedia for NUDT9 Gene

    Alternative splice isoforms for NUDT9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUDT9 Gene

Proteomics data for NUDT9 Gene at MOPED

Post-translational modifications for NUDT9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUDT9 Gene

No data available for DME Specific Peptides for NUDT9 Gene

Domains & Families for NUDT9 Gene

Gene Families for NUDT9 Gene

Protein Domains for NUDT9 Gene

Suggested Antigen Peptide Sequences for NUDT9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BW91

UniProtKB/Swiss-Prot:

NUDT9_HUMAN :
  • Contains 1 nudix hydrolase domain.
  • Belongs to the Nudix hydrolase family. NudF subfamily.
Domain:
  • Contains 1 nudix hydrolase domain.
Family:
  • Belongs to the Nudix hydrolase family. NudF subfamily.
genes like me logo Genes that share domains with NUDT9: view

Function for NUDT9 Gene

Molecular function for NUDT9 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ADP-D-ribose + H(2)O = AMP + D-ribose 5-phosphate.
UniProtKB/Swiss-Prot Function:
Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5-phosphate.
UniProtKB/Swiss-Prot Induction:
Isoform 1 is inhibited by fluoride and N-acetyl-p-benzoquinoneimine.

Enzyme Numbers (IUBMB) for NUDT9 Gene

genes like me logo Genes that share phenotypes with NUDT9: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NUDT9

miRNA for NUDT9 Gene

miRTarBase miRNAs that target NUDT9

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUDT9 Gene

Localization for NUDT9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDT9 Gene

Isoform 1: Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUDT9 Gene COMPARTMENTS Subcellular localization image for NUDT9 gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 3

No data available for Gene Ontology (GO) - Cellular Components for NUDT9 Gene

Pathways & Interactions for NUDT9 Gene

genes like me logo Genes that share pathways with NUDT9: view

Pathways by source for NUDT9 Gene

1 KEGG pathway for NUDT9 Gene

Interacting Proteins for NUDT9 Gene

Gene Ontology (GO) - Biological Process for NUDT9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044281 small molecule metabolic process TAS --
GO:0046709 IDP catabolic process IEA --
genes like me logo Genes that share ontologies with NUDT9: view

No data available for SIGNOR curated interactions for NUDT9 Gene

Drugs & Compounds for NUDT9 Gene

(5) Drugs for NUDT9 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
[(2r,3s,4s,5r)-3,4,5-Trihydroxytetrahydrofuran-2-Yl]Methyl Dihydrogen Phosphate Experimental Pharma Target 0
Beta-D-Glucose Experimental Pharma Target 0
Manganese Pharma 32
Magnesium Nutra 0

(5) Additional Compounds for NUDT9 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine diphosphate ribose
  • (Rib5)ppA
  • 5-(Adenosine 5'-pyrophosphoryl)-D-ribose
  • A5'pp5Rib
  • Adenosine 5'-diphosphoribose
  • Adenosine diphosphate ribose
20762-30-5
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
D-Ribose 5-phosphate
  • D-Ribose 5-phosphate
  • D-Ribose-5-P
  • D-Ribose-5-phosphate
  • D-Ribose-5-phosphorate
  • D-Ribose-5-phosphoric acid
3615-55-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with NUDT9: view

Transcripts for NUDT9 Gene

Unigene Clusters for NUDT9 Gene

Nudix (nucleoside diphosphate linked moiety X)-type motif 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT9 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12
SP1: - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4:
SP5:
SP6: - - - -
SP7: - - - - - - - -
SP8:
SP9: - -

Relevant External Links for NUDT9 Gene

GeneLoc Exon Structure for
NUDT9
ECgene alternative splicing isoforms for
NUDT9

Expression for NUDT9 Gene

mRNA expression in normal human tissues for NUDT9 Gene

Protein differential expression in normal tissues from HIPED for NUDT9 Gene

This gene is overexpressed in Testis (10.2), Adrenal (8.0), and Skin (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUDT9 Gene



SOURCE GeneReport for Unigene cluster for NUDT9 Gene Hs.149500

mRNA Expression by UniProt/SwissProt for NUDT9 Gene

Q9BW91-NUDT9_HUMAN
Tissue specificity: Ubiquitously expressed but isoform 1 is the most predominant isoform.
genes like me logo Genes that share expression patterns with NUDT9: view

Protein tissue co-expression partners for NUDT9 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NUDT9 Gene

Orthologs for NUDT9 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUDT9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NUDT9 35
  • 88.66 (n)
  • 85.01 (a)
NUDT9 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUDT9 35
  • 89.14 (n)
  • 87.14 (a)
NUDT9 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nudt9 35
  • 82.86 (n)
  • 89.43 (a)
Nudt9 16
Nudt9 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NUDT9 35
  • 99.14 (n)
  • 98.29 (a)
NUDT9 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nudt9 35
  • 82.29 (n)
  • 89.14 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia NUDT9 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUDT9 35
  • 71.1 (n)
  • 71.3 (a)
NUDT9 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUDT9 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5570 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.3444 35
zebrafish
(Danio rerio)
Actinopterygii nudt9 35
  • 58.85 (n)
  • 57.72 (a)
wufu33g07 35
nudt9 36
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG18217 37
  • 53 (a)
CG4098 37
  • 51 (a)
CG4098 35
  • 53.41 (n)
  • 53.53 (a)
CG4098 36
  • 48 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006085 35
  • 51.52 (n)
  • 50.65 (a)
worm
(Caenorhabditis elegans)
Secernentea ndx-6 35
  • 56.45 (n)
  • 52.82 (a)
ndx-6 36
  • 51 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToOne
Species with no ortholog for NUDT9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUDT9 Gene

ENSEMBL:
Gene Tree for NUDT9 (if available)
TreeFam:
Gene Tree for NUDT9 (if available)

Paralogs for NUDT9 Gene

(1) SIMAP similar genes for NUDT9 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for NUDT9 Gene

genes like me logo Genes that share paralogs with NUDT9: view

No data available for Paralogs for NUDT9 Gene

Variants for NUDT9 Gene

Sequence variations from dbSNP and Humsavar for NUDT9 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1128060 -- 87,458,085(+) GTATC(A/C)CAGAA utr-variant-3-prime
rs4324526 -- 87,447,678(+) TAAGC(A/G)ATTCA intron-variant
rs4493500 -- 87,428,086(+) ATACT(C/T)GCTCA intron-variant
rs4693163 -- 87,434,030(+) TTTAC(A/G)TAGAC intron-variant
rs4693817 -- 87,438,634(+) TATCT(C/T)GGAAA intron-variant

Variation tolerance for NUDT9 Gene

Residual Variation Intolerance Score: 36.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.49; 43.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUDT9 Gene

HapMap Linkage Disequilibrium report
NUDT9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NUDT9 Gene

Disorders for NUDT9 Gene

Relevant External Links for NUDT9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUDT9

No disorders were found for NUDT9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUDT9 Gene

Publications for NUDT9 Gene

  1. NUDT9, a member of the Nudix hydrolase family, is an evolutionarily conserved mitochondrial ADP-ribose pyrophosphatase. (PMID: 12427752) Perraud A.-L. … Scharenberg A.M. (J. Biol. Chem. 2003) 2 3 4 23 67
  2. Differential expression of NUDT9 at different phases of the menstrual cycle and in different components of normal and neoplastic human endometrium. (PMID: 19574167) Chen L.Y. … Chen M. (Taiwan J Obstet Gynecol 2009) 3 23
  3. The specific, submicromolar-Km ADP-ribose pyrophosphatase purified from human placenta is enzymically indistinguishable from recombinant NUDT9 protein, including a selectivity for Mn2+ as activating cation and increase in Km for ADP-ribose, both elicited by H2O2. (PMID: 16860484) Carloto A. … Ribeiro J.M. (Biochim. Biophys. Acta 2006) 3 23
  4. Interaction of C17orf25 with ADP-ribose pyrophosphatase NUDT9 detected via yeast two-hybrid method. (PMID: 12897971) Zhang H.-T. … Gong Y. (Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 2003) 3 23
  5. ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. (PMID: 11385575) Perraud A.-L. … Scharenberg A.M. (Nature 2001) 2 3

Products for NUDT9 Gene

Sources for NUDT9 Gene

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