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NUDT9 Gene

protein-coding   GIFtS: 57

GC04P088645
nudix (nucleoside diphosphate linked moiety X)-type motif 9
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
ADPR-PPase 3
EC 3.6.1.13 3
MGC3037 1, 2
NUDT10 2, 3
Descriptions
ADP-ribose diphosphatase 2, 3
ADP-ribose phosphohydrolase 2, 3
ADP-ribose pyrosphosphatase NUDT9 2
Adenosine diphosphoribose pyrophosphatase 2, 3
Nucleoside diphosphate-linked moiety X motif 9 3
Nudix motif 9 3
nucleoside diphosphate linked moiety X-type motif 9 2
nudix (nucleoside diphosphate linked moiety X)-type motif 9 2
nudix-type motif 9 2
External Ids
HGNC: 80561
Entrez Gene: 533432
UniProtKB: Q9BW913
Ensembl: ENSG000001705027
Search outside databases for aliases for NUDT9 gene

Previous GC identifers: GC04P088501 GC04P088802 GC04P088700

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: NUDT9_HUMAN, Q9BW91
Function: Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate

Gene Wiki entry for NUDT9

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the NUDT9 gene  

Entrez Gene cytogenetic band: 4q22.1   Ensembl cytogenetic band:  4q22.1   HGNC cytogenetic band: 4q22.1

NUDT9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P088645:     (about GC identifiers)

Start:
88,562,759 bp from pter
End:
88,598,523 bp from pter
Size:
35,765 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000004.10  NT_016354.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: NUDT9_HUMAN, Q9BW91 (See protein sequence)
Recommended Name: ADP-ribose pyrophosphatase, mitochondrial precursor  
Size: 350 amino acids; 39125 Da
Cofactor: Magnesium
Cofactor: Manganese
Subunit: Monomer. Interacts with C17orf25
Subcellular location: Isoform 1: Mitochondrion
PDB structure from and Proteopedia :
1Q33 (3D)    1QVJ (3D)    
Secondary accessions: Q8NBN1 Q8NCB9 Q8NG25
Alternative splicing: 2 isoforms:  Q9BW91-1   Q9BW91-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_076952.1  NP_932155.1  


    ENSEMBL proteins: 
    ENSP00000350728 ENSP00000303575 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (NUDT9)
    Human Recombinant Proteins from Abnova (NUDT9)
                  OriGene Purified Recombinant Human Protein: NUDT9 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular NAS11385575
    GO:0005739 mitochondrion IEA--
    About this table

    Antibodies for NUDT9: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for NUDT9
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (NUDT9), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (NUDT9)
    Novus Biologicals Antibodies for NUDT9

    Assays for NUDT9: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR000086 NUDIX_hydrolase_core


       GeneDecks  NUDT9 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9BW91

    ProtoNet protein and cluster: Q9BW91

    1 Blocks protein family: IPB000086 NUDIX hydrolase

    UniProtKB/Swiss-Prot: NUDT9_HUMAN, Q9BW91
    Similarity: Belongs to the Nudix hydrolase family. NudF subfamily

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (NUDT9)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (NUDT9)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_198038

                  Applied Biosystems Silencer® siRNAs for NUDT9

                  Sigma-Aldrich siRNA for NUDT9  
                         Sigma-Aldrich shRNA for NUDT9  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for NUDT9
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_024047
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_024047
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_024047 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_024047

    UniProtKB/Swiss-Prot: NUDT9_HUMAN, Q9BW91
    Function: Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate
    Catalytic activity: ADP-ribose + H(2)O = AMP + D-ribose 5-phosphate
    Induction: Isoform 1 is inhibited by fluoride and N-acetyl-p-benzoquinoneimine
    Enzyme Number (IUBMB): EC 3.6.1.13 

    1 MGI phenotypic allele for Nudt9 (no phenotypes)


    5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287 magnesium ion binding IEA--
    GO:0005227 calcium activated cation channel activity NAS11385575
    GO:0016787 hydrolase activity IEA--
    GO:0017110 nucleoside-diphosphatase activity IEA--
    GO:0030145 manganese ion binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    2 Sigma-Aldrich "Your Favorite Gene" Pathways for  NUDT9  (Your Favorite Gene powered by Ingenuity) 
     Purine Metabolism
     Pyrimidine Metabolism

       GeneDecks  NUDT9 for the pathways selected above  
    About GeneDecksing

    1 Kegg Pathway  (Kegg details for NUDT9):
     hsa00230 Purine metabolism

       GeneDecks  NUDT9 for the pathways selected above  
    About GeneDecksing

    5/7 Interacting proteins for NUDT9 (ENSP000003035753) via UniProtKB, MINT, and/or STRING (see all 7 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NUDT5ENSP000003682193STRING (score=.946)
    PRPS1ENSP000003615123STRING (score=.899)
    PRPS2ENSP000003700433STRING (score=.899)
    GLOD4ENSP000003013283STRING (score=.867)
    TRPM7ENSP000003202393STRING (score=.793)
    About this table

    3 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006812 cation transport NAS11385575
    GO:0046032 ADP catabolic process IEA--
    GO:0046709 IDP catabolic process IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for NUDT9

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (NUDT9)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (NUDT9)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_198038

                  Sigma-Aldrich siRNA for NUDT9  
                         Sigma-Aldrich shRNA for NUDT9  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_024047  NM_198038  

    REFSEQ mRNAs for NUDT9 gene (2 alternative transcripts): 

    NM_024047.3   NM_198038.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_024047  NM_198038  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_024047
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_024047
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_024047 

    Additional cDNA sequence: 

    AF265341.1 AF273028.1 AK027295.1 AK075408.1 AK308028.1 AY026252.1 AY359123.1 BC000542.2 
    CR597296.1 CR604538.1 CR619203.1 CR620878.1 CR626425.1 

    13 DOTS entries:

    DT.315308  DT.92045022  DT.100841614  DT.100027645  DT.100819331  DT.92426610  DT.100027640  DT.121234885 
    DT.315309  DT.100819324  DT.121234852  DT.92426611  DT.95170258 

    24/240 AceView cDNA sequences (see all 240 ):

    BQ876864 AI522180 AI376380 AI262640 CR619203 AI473262 BI836200 BM825595 
    AW067801 BQ003544 BM769664 CB960100 CF552699 BQ130633 BX113602 NM_198039 
    BE313464 AK074845 CD243190 AI473395 BF589881 BM818963 BQ020812 CR604538 

    highest scoring ESTs for NUDT9:

    AW000891 AA151649 AA317639 AA449304 AA478767 AA526157 AA558703 AA640299 AA643644 AA644080 

    Unigene Cluster for NUDT9:

    Nudix (nucleoside diphosphate linked moiety X)-type motif 9
    Hs.149500  [show with all ESTs]
    Unigene Representative Sequence: BM923755


    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for NUDT9 (see all 9 )

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12
    SP1:                                            -                                   -     -                                       
    SP2:                          -     -     -     -                                   -     -                                       
    SP3:                    -     -     -     -     -                                   -     -                                       
    SP4:                                                                                                                              
    SP5:                                                                                                                              

    About this scheme

    ECgene alternative splicing isoforms for NUDT9

    2 Ensembl transcripts including schematic representations:
    ENST00000358033  ENST00000302174  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    NUDT9 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for NUDT9

    1 / 2 / 3

    3 probe-sets matching NUDT9 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    78421_at2, 3 U95-E 1 1.00 1.00 1.00 1.00 AW000891 1.00 1.00 1.00 1

    218375_at2, 3 U133-A 1 1.00 1.00 -- -- NM_024047 0.60 1.00 0.82 1

    218375_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  NUDT9 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GCTTAAATTA

    SOURCE GeneReport for Unigene cluster: Hs.149500

    UniProtKB/Swiss-Prot: NUDT9_HUMAN, Q9BW91
    Tissue specificity: Ubiquitously expressed but isoform 1 is the most predominant isoform

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for NUDT9 gene from 5/12 species (see all 12 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    NUDT91   -- nudix (nucleoside diphosphate linked moiety X)-type more 89.14(n)
    87.14(a)
    478469  XM_535647.2  XP_535647.1 
    chimpanzee
    (Pan troglodytes)
    NUDT91   -- nudix (nucleoside diphosphate linked moiety X)-type more 99.14(n)
    98.29(a)
    471246  XM_526628.2  XP_526628.1 
    cow
    (Bos taurus)
    NUDT91   -- nudix (nucleoside diphosphate linked moiety X)-type more 88.66(n)
    85.01(a)
    517589  XM_595761.3  XP_595761.3 
    rat
    (Rattus norvegicus)
    Nudt91   -- nudix (nucleoside diphosphate linked moiety X)-type more 82.29(n)
    89.14(a)
    305149  NM_001006991.1  NP_001006992.1 
    mouse
    (Mus musculus)
    Nudt91, 5 55
    nudix (nucleoside diphosphate linked moiety X)-type more1, 5 82.86(n)1
    89.43(a)1
    741671  NM_028794.31  NP_083070.21 
     AI4624745  AK0044445  (see all 15)
    About this table        Species with no ortholog for NUDT9

    ENSEMBL Gene Tree for NUDT9
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Pseudogenes
    1 related pseudogene


    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/232 NCBI SNPs in NUDT9 are shown (see all 232 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 84)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 4 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs119352261,2
    A,C,F,H88561174(+) tctatC/Ttcgtg 2 -- ng514Minor allele frequency- T:0.09EU EA WA 404
    rs119452321,2
    A,C,F,H88561393(+) AATGAA/GGTAAG 2 -- ng51 tfbs38Minor allele frequency- G:0.29EU EA WA 836
    rs119365451,2
    C,F,H88562211(+) CTTCCG/CCAACA 2 -- ng514Minor allele frequency- C:0.01EU EA WA 400
    rs68442061,2
    F,H88560866(+) cacttT/Cgttat 2 -- ng514Minor allele frequency- C:0.02EU EA WA 418
    rs283727751,2
    C,F88562728(+) AGCCGG/ACAACG 2 -- ng512Minor allele frequency- A:0.21MN EA 1252
    rs11280601,2
    F88598261(+) GTATCA/CCAGAA 2 -- ut31 ese31Minor allele frequency- C:0.02MN 184
    --
    rs283727761,2
    F88562938(+) CACAGCTACTCC 
    CGTTCG
    /-
    GGAAC
    2 -- int1 ut512Minor allele frequency- -:0.28MN EA 1252
    rs119377701,2
    A,C,F,H88563087(+) ATGGCG/CGGACG 2 A/A syn1 int1 ese34Minor allele frequency- C:0.11EU EA WA 412
    rs65319971,2
    A,C,F,H88584511(+) CCCATA/TCTCAC 2 -- int17Minor allele frequency- T:0.42NA EU EA WA 548
    rs100277861,2
    A,C,F,H88566536(+) TCTCAA/GTTGTG 2 -- int14Minor allele frequency- G:0.22EU EA WA 384
    About this table

    HapMap Linkage Disequilibrium images for NUDT9 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 606022

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/15 PubMed articles for NUDT9 gene (see all 15 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 53343 HGNC: 8056 AceView: NUDT9 Ensembl:ENSG00000170502 euGenes: HUgn53343
    ECgene: NUDT9 H-InvDB: NUDT9
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for NUDT9:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for NUDT9-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
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     Predesigned and custom siRNAs for NUDT9 Antibodies for NUDT9
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for NUDT9 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     shRNA in GFP-retroviral vector
     Search Tocris compounds for NUDT9




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for NUDT9

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