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Aliases for NUDT9 Gene

Aliases for NUDT9 Gene

  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 9 2 3
  • Adenosine Diphosphoribose Pyrophosphatase 3 4
  • ADP-Ribose Phosphohydrolase 3 4
  • ADP-Ribose Diphosphatase 3 4
  • ADPR-PPase 3 4
  • NUDT10 3 4
  • Nucleoside Diphosphate Linked Moiety X-Type Motif 9 3
  • Nucleoside Diphosphate-Linked Moiety X Motif 9 4
  • ADP-Ribose Pyrophosphatase, Mitochondrial 3
  • ADP-Ribose Pyrosphosphatase NUDT9 3
  • Nudix Motif 9 4
  • EC 3.6.1.13 4

External Ids for NUDT9 Gene

Summaries for NUDT9 Gene

Entrez Gene Summary for NUDT9 Gene

  • The protein encoded by this gene belongs to the Nudix hydrolase family. Nudix boxes are found in a family of diverse enzymes that catalyze the hydrolysis of nucleoside diphosphate derivatives. This enzyme is an ADP-ribose pyrophosphatase that catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. It requires divalent metal ions and an intact Nudix motif for enzymatic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for NUDT9 Gene

NUDT9 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 9) is a Protein Coding gene. Among its related pathways are Metabolism and Purine metabolism (REACTOME). GO annotations related to this gene include ADP-sugar diphosphatase activity and adenosine-diphosphatase activity.

UniProtKB/Swiss-Prot for NUDT9 Gene

  • Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5-phosphate

Gene Wiki entry for NUDT9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT9 Gene

Genomics for NUDT9 Gene

Genomic Location for NUDT9 Gene

Start:
87,422,576 bp from pter
End:
87,459,454 bp from pter
Size:
36,879 bases
Orientation:
Plus strand

Genomic View for NUDT9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUDT9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT9 Gene

Regulatory Elements for NUDT9 Gene

Proteins for NUDT9 Gene

  • Protein details for NUDT9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BW91-NUDT9_HUMAN
    Recommended name:
    ADP-ribose pyrophosphatase, mitochondrial
    Protein Accession:
    Q9BW91
    Secondary Accessions:
    • Q8NBN1
    • Q8NCB9
    • Q8NG25

    Protein attributes for NUDT9 Gene

    Size:
    350 amino acids
    Molecular mass:
    39125 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Monomer. Interacts with GLOD4.

    Three dimensional structures from OCA and Proteopedia for NUDT9 Gene

    Alternative splice isoforms for NUDT9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUDT9 Gene

Proteomics data for NUDT9 Gene at MOPED

Post-translational modifications for NUDT9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUDT9 Gene

No data available for DME Specific Peptides for NUDT9 Gene

Domains for NUDT9 Gene

Gene Families for NUDT9 Gene

HGNC:
  • NUDT :Nudix motif containing

Protein Domains for NUDT9 Gene

UniProtKB/Swiss-Prot:

NUDT9_HUMAN
Domain:
  • Contains 1 nudix hydrolase domain.:
    • Q9BW91
Family:
  • Belongs to the Nudix hydrolase family. NudF subfamily.:
    • Q9BW91
genes like me logo Genes that share domains with NUDT9: view

Function for NUDT9 Gene

Molecular function for NUDT9 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ADP-D-ribose + H(2)O = AMP + D-ribose 5-phosphate
UniProtKB/Swiss-Prot Function: Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5-phosphate
UniProtKB/Swiss-Prot Induction: Isoform 1 is inhibited by fluoride and N-acetyl-p-benzoquinoneimine.

Enzyme Numbers (IUBMB) for NUDT9 Gene

Gene Ontology (GO) - Molecular Function for NUDT9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity --
GO:0019144 ADP-sugar diphosphatase activity NAS 11385575
GO:0043262 adenosine-diphosphatase activity IEA --
GO:0047631 ADP-ribose diphosphatase activity EXP --
genes like me logo Genes that share ontologies with NUDT9: view

miRNA for NUDT9 Gene

miRTarBase miRNAs that target NUDT9

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NUDT9 Gene

Localization for NUDT9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDT9 Gene

Isoform 1: Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUDT9 Gene COMPARTMENTS Subcellular localization image for NUDT9 gene
Compartment Confidence
mitochondrion 5
nucleus 3
extracellular 1

Gene Ontology (GO) - Cellular Components for NUDT9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular NAS 11385575
GO:0005759 mitochondrial matrix TAS --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with NUDT9: view

Pathways for NUDT9 Gene

genes like me logo Genes that share pathways with NUDT9: view

Interacting Proteins for NUDT9 Gene

Gene Ontology (GO) - Biological Process for NUDT9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0034656 nucleobase-containing small molecule catabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0046032 ADP catabolic process IEA --
GO:0046709 IDP catabolic process IEA --
genes like me logo Genes that share ontologies with NUDT9: view

Compounds for NUDT9 Gene

(4) HMDB Compounds for NUDT9 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine diphosphate ribose
  • (Rib5)ppA
20762-30-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4
Manganese
  • manganese
7439-96-5

(2) Drugbank Compounds for NUDT9 Gene

(1) Novoseek inferred chemical compound relationships for NUDT9 Gene

Compound -log(P) Hits PubMed IDs
adpribose 84.9 6
genes like me logo Genes that share compounds with NUDT9: view

Transcripts for NUDT9 Gene

Unigene Clusters for NUDT9 Gene

Nudix (nucleoside diphosphate linked moiety X)-type motif 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT9 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12
SP1: - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4:
SP5:
SP6: - - - -
SP7: - - - - - - - -
SP8:
SP9: - -

Relevant External Links for NUDT9 Gene

GeneLoc Exon Structure for
NUDT9
ECgene alternative splicing isoforms for
NUDT9

Expression for NUDT9 Gene

mRNA expression in normal human tissues for NUDT9 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUDT9 Gene

SOURCE GeneReport for Unigene cluster for NUDT9 Gene Hs.149500

mRNA Expression by UniProt/SwissProt for NUDT9 Gene

Q9BW91-NUDT9_HUMAN
Tissue specificity: Ubiquitously expressed but isoform 1 is the most predominant isoform.
genes like me logo Genes that share expressions with NUDT9: view

Orthologs for NUDT9 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUDT9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUDT9 36
  • 99.14 (n)
  • 98.29 (a)
NUDT9 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NUDT9 36
  • 88.66 (n)
  • 85.01 (a)
NUDT9 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUDT9 36
  • 89.14 (n)
  • 87.14 (a)
NUDT9 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nudt9 36
  • 82.86 (n)
  • 89.43 (a)
Nudt9 16
Nudt9 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 70 (a)
OneToMany
-- 37
  • 85 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia NUDT9 37
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nudt9 36
  • 82.29 (n)
  • 89.14 (a)
chicken
(Gallus gallus)
Aves NUDT9 36
  • 71.1 (n)
  • 71.3 (a)
NUDT9 37
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUDT9 37
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3444 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5570 36
zebrafish
(Danio rerio)
Actinopterygii nudt9 36
  • 58.85 (n)
  • 57.72 (a)
nudt9 37
  • 54 (a)
OneToOne
wufu33g07 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006085 36
  • 51.52 (n)
  • 50.65 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4098 36
  • 53.41 (n)
  • 53.53 (a)
CG4098 37
  • 48 (a)
OneToOne
CG4098 38
  • 51 (a)
CG18217 38
  • 53 (a)
worm
(Caenorhabditis elegans)
Secernentea ndx-6 36
  • 56.45 (n)
  • 52.82 (a)
ndx-6 37
  • 51 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 47 (a)
OneToOne
Species with no ortholog for NUDT9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUDT9 Gene

ENSEMBL:
Gene Tree for NUDT9 (if available)
TreeFam:
Gene Tree for NUDT9 (if available)

Paralogs for NUDT9 Gene

Selected SIMAP similar genes for NUDT9 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for NUDT9 Gene

genes like me logo Genes that share paralogs with NUDT9: view

No data available for Paralogs for NUDT9 Gene

Variants for NUDT9 Gene

Sequence variations from dbSNP and Humsavar for NUDT9 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1128060 -- 87,458,085(+) GTATC(A/C)CAGAA utr-variant-3-prime
rs4324526 -- 87,447,678(+) TAAGC(A/G)ATTCA intron-variant
rs4493500 -- 87,428,086(+) ATACT(C/T)GCTCA intron-variant
rs4642210 -- 87,455,630(+) ttagc(A/G)tgctt intron-variant
rs4643778 -- 87,459,456(+) TGTTA(A/G)CCATG downstream-variant-500B

Relevant External Links for NUDT9 Gene

HapMap Linkage Disequilibrium report
NUDT9

No data available for Structural Variations from Database of Genomic Variants (DGV) for NUDT9 Gene

Disorders for NUDT9 Gene

No disorders were found for NUDT9 Gene.

No data available for UniProtKB/Swiss-Prot for NUDT9 Gene

Publications for NUDT9 Gene

  1. NUDT9, a member of the Nudix hydrolase family, is an evolutionarily conserved mitochondrial ADP-ribose pyrophosphatase. (PMID: 12427752) Perraud A.-L. … Scharenberg A.M. (J. Biol. Chem. 2003) 2 3 4 23
  2. Interaction of C17orf25 with ADP-ribose pyrophosphatase NUDT9 detected via yeast two-hybrid method. (PMID: 12897971) Zhang H.-T. … Gong Y. (Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 2003) 3 4 23
  3. ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. (PMID: 11385575) Perraud A.-L. … Scharenberg A.M. (Nature 2001) 2 3 4
  4. Cloning, expression and characterisation of a human Nudix hydrolase specific for adenosine 5'-diphosphoribose (ADP-ribose). (PMID: 11825615) Lin S. … McLennan A.G. (Biochim. Biophys. Acta 2002) 3 4
  5. Differential expression of NUDT9 at different phases of the menstrual cycle and in different components of normal and neoplastic human endometrium. (PMID: 19574167) Chen L.Y. … Chen M. (Taiwan J Obstet Gynecol 2009) 3 23

Products for NUDT9 Gene

Sources for NUDT9 Gene

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