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Aliases for NUDT8 Gene

Aliases for NUDT8 Gene

  • Nudix Hydrolase 8 2 3 5
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 8 2
  • Nudix Motif 8 4
  • EC 3.6.1.- 4

External Ids for NUDT8 Gene

Previous GeneCards Identifiers for NUDT8 Gene

  • GC11U990247
  • GC11M067645
  • GC11M067170
  • GC11M067151
  • GC11M067395
  • GC11M063724

Summaries for NUDT8 Gene

GeneCards Summary for NUDT8 Gene

NUDT8 (Nudix Hydrolase 8) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is NUDT7.

UniProtKB/Swiss-Prot for NUDT8 Gene

  • Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT8 Gene

Genomics for NUDT8 Gene

Regulatory Elements for NUDT8 Gene

Enhancers for NUDT8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around NUDT8 on UCSC Golden Path with GeneCards custom track

Promoters for NUDT8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for NUDT8 Gene

Chromosome:
11
Start:
67,627,938 bp from pter
End:
67,629,937 bp from pter
Size:
2,000 bases
Orientation:
Minus strand

Genomic View for NUDT8 Gene

Genes around NUDT8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDT8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDT8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT8 Gene

Proteins for NUDT8 Gene

  • Protein details for NUDT8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WV74-NUDT8_HUMAN
    Recommended name:
    Nucleoside diphosphate-linked moiety X motif 8
    Protein Accession:
    Q8WV74
    Secondary Accessions:
    • Q6ZW59

    Protein attributes for NUDT8 Gene

    Size:
    236 amino acids
    Molecular mass:
    25370 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NUDT8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUDT8 Gene

Post-translational modifications for NUDT8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUDT8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NUDT8 Gene

Domains & Families for NUDT8 Gene

Gene Families for NUDT8 Gene

Protein Domains for NUDT8 Gene

Suggested Antigen Peptide Sequences for NUDT8 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WV74

UniProtKB/Swiss-Prot:

NUDT8_HUMAN :
  • Contains 1 nudix hydrolase domain.
  • Belongs to the Nudix hydrolase family.
Domain:
  • Contains 1 nudix hydrolase domain.
Family:
  • Belongs to the Nudix hydrolase family.
genes like me logo Genes that share domains with NUDT8: view

Function for NUDT8 Gene

Molecular function for NUDT8 Gene

UniProtKB/Swiss-Prot Function:
Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.

Enzyme Numbers (IUBMB) for NUDT8 Gene

Gene Ontology (GO) - Molecular Function for NUDT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NUDT8: view
genes like me logo Genes that share phenotypes with NUDT8: view

Animal Model Products

CRISPR Products

miRNA for NUDT8 Gene

miRTarBase miRNAs that target NUDT8

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUDT8 Gene

Localization for NUDT8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUDT8 Gene COMPARTMENTS Subcellular localization image for NUDT8 gene
Compartment Confidence
cytosol 3
mitochondrion 3
nucleus 2
extracellular 1
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NUDT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with NUDT8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NUDT8 Gene

Pathways & Interactions for NUDT8 Gene

SuperPathways for NUDT8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NUDT8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NUDT8 Gene

Drugs & Compounds for NUDT8 Gene

(4) Drugs for NUDT8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Approved Nutra 33
CDP Experimental Pharma 0
Guanosine diphosphate Experimental Pharma 0
Magnesium Nutra 0

(2) Additional Compounds for NUDT8 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
dTDP
  • Deoxy-TDP
  • Deoxythymidine 5'-diphosphate
  • dTDP
  • TDP
  • Thymidine 5'-diphosphate
491-97-4
genes like me logo Genes that share compounds with NUDT8: view

Transcripts for NUDT8 Gene

mRNA/cDNA for NUDT8 Gene

Unigene Clusters for NUDT8 Gene

Nudix (nucleoside diphosphate linked moiety X)-type motif 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT8 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4
SP1: -
SP2: -
SP3:

Relevant External Links for NUDT8 Gene

GeneLoc Exon Structure for
NUDT8
ECgene alternative splicing isoforms for
NUDT8

Expression for NUDT8 Gene

mRNA expression in normal human tissues for NUDT8 Gene

mRNA differential expression in normal tissues according to GTEx for NUDT8 Gene

This gene is overexpressed in Heart - Left Ventricle (x5.7) and Heart - Atrial Appendage (x4.8).

Protein differential expression in normal tissues from HIPED for NUDT8 Gene

This gene is overexpressed in Heart (15.7), Gallbladder (15.3), Kidney (11.3), Salivary gland (8.7), and Liver (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NUDT8 Gene



NURSA nuclear receptor signaling pathways regulating expression of NUDT8 Gene:

NUDT8

SOURCE GeneReport for Unigene cluster for NUDT8 Gene:

Hs.433329
genes like me logo Genes that share expression patterns with NUDT8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for NUDT8 Gene

Orthologs for NUDT8 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUDT8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NUDT8 34
  • 87.09 (n)
  • 91.18 (a)
NUDT8 35
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUDT8 34
  • 85.55 (n)
  • 89.66 (a)
NUDT8 35
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nudt8 34
  • 81.94 (n)
  • 83.25 (a)
Nudt8 16
Nudt8 35
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NUDT8 34
  • 99.86 (n)
  • 100 (a)
NUDT8 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nudt8 34
  • 82.27 (n)
  • 82.27 (a)
oppossum
(Monodelphis domestica)
Mammalia NUDT8 35
  • 39 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUDT8 34
  • 65.42 (n)
  • 60.45 (a)
NUDT8 35
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUDT8 35
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487518 34
  • 52.08 (n)
  • 50 (a)
zebrafish
(Danio rerio)
Actinopterygii nudt8 34
  • 57.73 (n)
  • 55.67 (a)
nudt8 35
  • 30 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000942 34
  • 48.54 (n)
  • 42.69 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11095 34
  • 50.59 (n)
  • 40 (a)
CG11095 35
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ndx-3 34
  • 45.57 (n)
  • 40.11 (a)
ndx-3 35
  • 29 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6580 35
  • 26 (a)
OneToOne
Species where no ortholog for NUDT8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUDT8 Gene

ENSEMBL:
Gene Tree for NUDT8 (if available)
TreeFam:
Gene Tree for NUDT8 (if available)

Paralogs for NUDT8 Gene

Paralogs for NUDT8 Gene

genes like me logo Genes that share paralogs with NUDT8: view

Variants for NUDT8 Gene

Sequence variations from dbSNP and Humsavar for NUDT8 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs34195815 -- 67,629,823(+) CCGAC(-/G)CGGGC reference, frameshift-variant
rs35118978 -- 67,628,426(+) TCAGG(C/G)AAGCA intron-variant
rs35181012 -- 67,628,163(+) TGTAG(C/G/T)GGAAG reference, missense, utr-variant-3-prime
rs138933955 -- 67,628,330(+) CCTCC(A/G)AGTTG reference, missense
rs138977536 -- 67,628,325(+) CACCT(C/G)CTCCG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NUDT8 Gene

Variant ID Type Subtype PubMed ID
dgv1214n100 CNV gain 25217958
dgv154n27 CNV loss 19166990
dgv1981n54 CNV gain 21841781
dgv1982n54 CNV loss 21841781
esv2422195 CNV duplication 17116639
nsv1070046 CNV deletion 25765185
nsv1143690 CNV deletion 24896259
nsv468606 CNV gain 19166990
nsv468609 CNV loss 19166990
nsv469963 CNV loss 18288195
nsv555272 CNV loss 21841781
nsv555273 CNV loss 21841781
nsv951023 CNV deletion 24416366

Variation tolerance for NUDT8 Gene

Residual Variation Intolerance Score: 46.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.88; 48.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUDT8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUDT8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT8 Gene

Disorders for NUDT8 Gene

Relevant External Links for NUDT8

Genetic Association Database (GAD)
NUDT8
Human Genome Epidemiology (HuGE) Navigator
NUDT8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUDT8

No disorders were found for NUDT8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUDT8 Gene

Publications for NUDT8 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  4. The mouse Nudt7 gene encodes a peroxisomal nudix hydrolase specific for coenzyme A and its derivatives. (PMID: 11415433) Gasmi L. … McLennan A.G. (Biochem. J. 2001) 2 3 65
  5. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd B.J. … Pagliarini D.J. (Mol. Cell 2016) 3 65

Products for NUDT8 Gene

Sources for NUDT8 Gene

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