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Aliases for NUDT8 Gene

Aliases for NUDT8 Gene

  • Nudix Hydrolase 8 2 3 5
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 8 2
  • Nudix Motif 8 4
  • EC 3.6.1.- 4

External Ids for NUDT8 Gene

Previous GeneCards Identifiers for NUDT8 Gene

  • GC11U990247
  • GC11M067645
  • GC11M067170
  • GC11M067151
  • GC11M067395
  • GC11M063724

Summaries for NUDT8 Gene

GeneCards Summary for NUDT8 Gene

NUDT8 (Nudix Hydrolase 8) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is NUDT7.

UniProtKB/Swiss-Prot for NUDT8 Gene

  • Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.

Additional gene information for NUDT8 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT8 Gene

Genomics for NUDT8 Gene

Regulatory Elements for NUDT8 Gene

Enhancers for NUDT8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H067579 1.6 Ensembl ENCODE dbSUPER 36.2 +45.6 45601 10 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 ZNF143 ENSG00000255119 NUDT8 PTPRCAP NDUFV1 C11orf72 DOC2GP RHOD LRP5 ALDH3B2 CDK2AP2
GH11H067627 1.4 ENCODE dbSUPER 26.7 -1.4 -1351 8 HDGF MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 PPP6R3 NUDT8 ENSG00000260808 DOC2GP ENSG00000255119 ENSG00000258297 KDM2A RAD9A RBM4 RPS6KB2
GH11H067612 1.4 Ensembl ENCODE dbSUPER 25.4 +15.3 15302 4 HDGF PKNOX1 PTBP1 RB1 RAD21 GLIS2 SCRT2 ZNF143 ZNF207 ATF7 NUDT8 DOC2GP ANKRD13D RAD9A CDK2AP2 PIR42297
GH11H067604 1.4 ENCODE dbSUPER 25.2 +23.3 23320 3 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF207 ENSG00000255119 NUDT8 NDUFV1 CDK2AP2 C11orf72
GH11H067572 1.5 Ensembl ENCODE dbSUPER 12 +56.9 56928 1 HDGF PKNOX1 ATF1 FOXA2 ARNT ARID4B ZNF2 TCF12 ZNF143 FOS NDUFV1 RBM14 RBM4B ENSG00000255119 C11orf72 DOC2GP NUDT8 TBX10 KDM2A PPP6R3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NUDT8 on UCSC Golden Path with GeneCards custom track

Promoters for NUDT8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000041138 -163 1401 HDGF MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF766 ZNF143

Genomic Location for NUDT8 Gene

Chromosome:
11
Start:
67,627,938 bp from pter
End:
67,629,937 bp from pter
Size:
2,000 bases
Orientation:
Minus strand

Genomic View for NUDT8 Gene

Genes around NUDT8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDT8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDT8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT8 Gene

Proteins for NUDT8 Gene

  • Protein details for NUDT8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WV74-NUDT8_HUMAN
    Recommended name:
    Nucleoside diphosphate-linked moiety X motif 8
    Protein Accession:
    Q8WV74
    Secondary Accessions:
    • Q6ZW59

    Protein attributes for NUDT8 Gene

    Size:
    236 amino acids
    Molecular mass:
    25370 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NUDT8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUDT8 Gene

Post-translational modifications for NUDT8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUDT8 Gene

No data available for DME Specific Peptides for NUDT8 Gene

Domains & Families for NUDT8 Gene

Gene Families for NUDT8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NUDT8 Gene

Suggested Antigen Peptide Sequences for NUDT8 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WV74

UniProtKB/Swiss-Prot:

NUDT8_HUMAN :
  • Belongs to the Nudix hydrolase family.
Family:
  • Belongs to the Nudix hydrolase family.
genes like me logo Genes that share domains with NUDT8: view

Function for NUDT8 Gene

Molecular function for NUDT8 Gene

UniProtKB/Swiss-Prot Function:
Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.

Enzyme Numbers (IUBMB) for NUDT8 Gene

Gene Ontology (GO) - Molecular Function for NUDT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NUDT8: view
genes like me logo Genes that share phenotypes with NUDT8: view

Animal Model Products

CRISPR Products

miRNA for NUDT8 Gene

miRTarBase miRNAs that target NUDT8

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NUDT8
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUDT8 Gene

Localization for NUDT8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUDT8 gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 2
plasma membrane 1
extracellular 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NUDT8 Gene

Pathways & Interactions for NUDT8 Gene

SuperPathways for NUDT8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NUDT8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NUDT8 Gene

Drugs & Compounds for NUDT8 Gene

(4) Drugs for NUDT8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Approved Nutra 35
CDP Experimental Pharma 0
Guanosine diphosphate Experimental Pharma 0
Magnesium Nutra 0

(2) Additional Compounds for NUDT8 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
dTDP
  • Deoxy-TDP
  • Deoxythymidine 5'-diphosphate
  • dTDP
  • TDP
  • Thymidine 5'-diphosphate
491-97-4
genes like me logo Genes that share compounds with NUDT8: view

Transcripts for NUDT8 Gene

mRNA/cDNA for NUDT8 Gene

Unigene Clusters for NUDT8 Gene

Nudix (nucleoside diphosphate linked moiety X)-type motif 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NUDT8
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT8 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4
SP1: -
SP2: -
SP3:

Relevant External Links for NUDT8 Gene

GeneLoc Exon Structure for
NUDT8
ECgene alternative splicing isoforms for
NUDT8

Expression for NUDT8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUDT8 Gene

mRNA differential expression in normal tissues according to GTEx for NUDT8 Gene

This gene is overexpressed in Heart - Left Ventricle (x5.7) and Heart - Atrial Appendage (x4.8).

Protein differential expression in normal tissues from HIPED for NUDT8 Gene

This gene is overexpressed in Heart (15.7), Gallbladder (15.3), Kidney (11.3), Salivary gland (8.7), and Liver (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NUDT8 Gene



NURSA nuclear receptor signaling pathways regulating expression of NUDT8 Gene:

NUDT8

SOURCE GeneReport for Unigene cluster for NUDT8 Gene:

Hs.433329
genes like me logo Genes that share expression patterns with NUDT8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUDT8 Gene

Orthologs for NUDT8 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUDT8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUDT8 33 34
  • 99.86 (n)
cow
(Bos Taurus)
Mammalia NUDT8 33 34
  • 87.09 (n)
dog
(Canis familiaris)
Mammalia NUDT8 33 34
  • 85.55 (n)
rat
(Rattus norvegicus)
Mammalia Nudt8 33
  • 82.27 (n)
mouse
(Mus musculus)
Mammalia Nudt8 33 16 34
  • 81.94 (n)
oppossum
(Monodelphis domestica)
Mammalia NUDT8 34
  • 39 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUDT8 33 34
  • 65.42 (n)
lizard
(Anolis carolinensis)
Reptilia NUDT8 34
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487518 33
  • 52.08 (n)
zebrafish
(Danio rerio)
Actinopterygii nudt8 33 34
  • 57.73 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11095 33 34
  • 50.59 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000942 33
  • 48.54 (n)
worm
(Caenorhabditis elegans)
Secernentea ndx-3 33 34
  • 45.57 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6580 34
  • 26 (a)
OneToOne
Species where no ortholog for NUDT8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUDT8 Gene

ENSEMBL:
Gene Tree for NUDT8 (if available)
TreeFam:
Gene Tree for NUDT8 (if available)

Paralogs for NUDT8 Gene

Paralogs for NUDT8 Gene

genes like me logo Genes that share paralogs with NUDT8: view

Variants for NUDT8 Gene

Sequence variations from dbSNP and Humsavar for NUDT8 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000006152 -- 67,627,058(+) TGTGA(C/T)AGGCT intron-variant
rs1000232630 -- 67,623,455(+) TTGCT(C/G)TTTTC intron-variant
rs1000701724 -- 67,629,484(+) AGGAC(A/G)CGTAC intron-variant
rs1001334269 -- 67,630,083(+) TCGGG(A/G)GGCCT upstream-variant-2KB, utr-variant-5-prime
rs1001554337 -- 67,624,224(+) TTCTA(A/G)CTAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUDT8 Gene

Variant ID Type Subtype PubMed ID
dgv1214n100 CNV gain 25217958
dgv154n27 CNV loss 19166990
dgv1981n54 CNV gain 21841781
dgv1982n54 CNV loss 21841781
esv2422195 CNV duplication 17116639
nsv1070046 CNV deletion 25765185
nsv1143690 CNV deletion 24896259
nsv468606 CNV gain 19166990
nsv468609 CNV loss 19166990
nsv469963 CNV loss 18288195
nsv555272 CNV loss 21841781
nsv555273 CNV loss 21841781
nsv951023 CNV deletion 24416366

Variation tolerance for NUDT8 Gene

Residual Variation Intolerance Score: 46.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.88; 48.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUDT8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUDT8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT8 Gene

Disorders for NUDT8 Gene

Relevant External Links for NUDT8

Genetic Association Database (GAD)
NUDT8
Human Genome Epidemiology (HuGE) Navigator
NUDT8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUDT8

No disorders were found for NUDT8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUDT8 Gene

Publications for NUDT8 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. The mouse Nudt7 gene encodes a peroxisomal nudix hydrolase specific for coenzyme A and its derivatives. (PMID: 11415433) Gasmi L … McLennan AG (The Biochemical journal 2001) 2 3 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for NUDT8 Gene

Sources for NUDT8 Gene

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