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Aliases for NUDT8 Gene

Aliases for NUDT8 Gene

  • Nudix Hydrolase 8 2 3 5
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 8 2
  • Nudix Motif 8 4
  • EC 3.6.1.- 4

External Ids for NUDT8 Gene

Previous GeneCards Identifiers for NUDT8 Gene

  • GC11U990247
  • GC11M067645
  • GC11M067170
  • GC11M067151
  • GC11M067395
  • GC11M063724

Summaries for NUDT8 Gene

GeneCards Summary for NUDT8 Gene

NUDT8 (Nudix Hydrolase 8) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is NUDT7.

UniProtKB/Swiss-Prot for NUDT8 Gene

  • Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT8 Gene

Genomics for NUDT8 Gene

Regulatory Elements for NUDT8 Gene

Promoters for NUDT8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NUDT8 on UCSC Golden Path with GeneCards custom track

Genomic Location for NUDT8 Gene

Chromosome:
11
Start:
67,627,938 bp from pter
End:
67,629,937 bp from pter
Size:
2,000 bases
Orientation:
Minus strand

Genomic View for NUDT8 Gene

Genes around NUDT8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDT8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDT8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT8 Gene

Proteins for NUDT8 Gene

  • Protein details for NUDT8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WV74-NUDT8_HUMAN
    Recommended name:
    Nucleoside diphosphate-linked moiety X motif 8
    Protein Accession:
    Q8WV74
    Secondary Accessions:
    • Q6ZW59

    Protein attributes for NUDT8 Gene

    Size:
    236 amino acids
    Molecular mass:
    25370 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NUDT8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUDT8 Gene

Proteomics data for NUDT8 Gene at MOPED

Post-translational modifications for NUDT8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUDT8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NUDT8 Gene

Domains & Families for NUDT8 Gene

Gene Families for NUDT8 Gene

Protein Domains for NUDT8 Gene

Suggested Antigen Peptide Sequences for NUDT8 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WV74

UniProtKB/Swiss-Prot:

NUDT8_HUMAN :
  • Contains 1 nudix hydrolase domain.
  • Belongs to the Nudix hydrolase family.
Domain:
  • Contains 1 nudix hydrolase domain.
Family:
  • Belongs to the Nudix hydrolase family.
genes like me logo Genes that share domains with NUDT8: view

Function for NUDT8 Gene

Molecular function for NUDT8 Gene

UniProtKB/Swiss-Prot Function:
Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.

Enzyme Numbers (IUBMB) for NUDT8 Gene

Gene Ontology (GO) - Molecular Function for NUDT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with NUDT8: view
genes like me logo Genes that share phenotypes with NUDT8: view

Animal Model Products

miRNA for NUDT8 Gene

miRTarBase miRNAs that target NUDT8

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUDT8 Gene

Localization for NUDT8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUDT8 Gene COMPARTMENTS Subcellular localization image for NUDT8 gene
Compartment Confidence
cytosol 3
mitochondrion 3
nucleus 2
extracellular 1
golgi apparatus 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NUDT8 Gene

Pathways & Interactions for NUDT8 Gene

SuperPathways for NUDT8 Gene

No Data Available

Interacting Proteins for NUDT8 Gene

Gene Ontology (GO) - Biological Process for NUDT8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NUDT8 Gene

Drugs & Compounds for NUDT8 Gene

(4) Drugs for NUDT8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
CDP Experimental Pharma 0
Guanosine diphosphate Experimental Pharma 0
Manganese Pharma 32
Magnesium Nutra 0

(2) Additional Compounds for NUDT8 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
dTDP
  • Deoxy-TDP
  • Deoxythymidine 5'-diphosphate
  • dTDP
  • TDP
  • Thymidine 5'-diphosphate
491-97-4
genes like me logo Genes that share compounds with NUDT8: view

Transcripts for NUDT8 Gene

mRNA/cDNA for NUDT8 Gene

Unigene Clusters for NUDT8 Gene

Nudix (nucleoside diphosphate linked moiety X)-type motif 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT8 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4
SP1: -
SP2: -
SP3:

Relevant External Links for NUDT8 Gene

GeneLoc Exon Structure for
NUDT8
ECgene alternative splicing isoforms for
NUDT8

Expression for NUDT8 Gene

mRNA expression in normal human tissues for NUDT8 Gene

mRNA differential expression in normal tissues according to GTEx for NUDT8 Gene

This gene is overexpressed in Heart - Left Ventricle (x5.7) and Heart - Atrial Appendage (x4.8).

Protein differential expression in normal tissues from HIPED for NUDT8 Gene

This gene is overexpressed in Heart (15.7), Gallbladder (15.3), Kidney (11.3), Salivary gland (8.7), and Liver (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUDT8 Gene



SOURCE GeneReport for Unigene cluster for NUDT8 Gene Hs.433329

genes like me logo Genes that share expression patterns with NUDT8: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NUDT8 Gene

Orthologs for NUDT8 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUDT8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NUDT8 35
  • 87.09 (n)
  • 91.18 (a)
NUDT8 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUDT8 35
  • 85.55 (n)
  • 89.66 (a)
NUDT8 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nudt8 35
  • 81.94 (n)
  • 83.25 (a)
Nudt8 16
Nudt8 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NUDT8 35
  • 99.86 (n)
  • 100 (a)
NUDT8 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nudt8 35
  • 82.27 (n)
  • 82.27 (a)
oppossum
(Monodelphis domestica)
Mammalia NUDT8 36
  • 39 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUDT8 35
  • 65.42 (n)
  • 60.45 (a)
NUDT8 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUDT8 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487518 35
  • 52.08 (n)
  • 50 (a)
zebrafish
(Danio rerio)
Actinopterygii nudt8 35
  • 57.73 (n)
  • 55.67 (a)
nudt8 36
  • 30 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000942 35
  • 48.54 (n)
  • 42.69 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11095 35
  • 50.59 (n)
  • 40 (a)
CG11095 36
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ndx-3 35
  • 45.57 (n)
  • 40.11 (a)
ndx-3 36
  • 29 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6580 36
  • 26 (a)
OneToOne
Species with no ortholog for NUDT8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUDT8 Gene

ENSEMBL:
Gene Tree for NUDT8 (if available)
TreeFam:
Gene Tree for NUDT8 (if available)

Paralogs for NUDT8 Gene

Paralogs for NUDT8 Gene

genes like me logo Genes that share paralogs with NUDT8: view

Variants for NUDT8 Gene

Sequence variations from dbSNP and Humsavar for NUDT8 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs7102670 -- 67,630,204(+) GGTCC(A/G)TTAGG upstream-variant-2KB
rs7102800 -- 67,630,261(+) CCCCC(A/G)GATGG upstream-variant-2KB
rs7124513 -- 67,628,243(+) AACAC(C/T)TCATC reference, synonymous-codon, utr-variant-3-prime
rs11227867 -- 67,628,481(+) AAGAC(C/T)CCTTT intron-variant
rs12282749 -- 67,630,262(+) CCCCG(C/G)ATggg upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NUDT8 Gene

Variant ID Type Subtype PubMed ID
nsv897801 CNV Loss 21882294
dgv1194n71 CNV Loss 21882294
esv2422195 CNV Duplication 17116639
dgv1196n71 CNV Loss 21882294
nsv897815 CNV Loss 21882294
nsv468606 CNV Gain 19166990
dgv1197n71 CNV Loss 21882294
dgv154n27 CNV Loss 19166990
dgv1198n71 CNV Loss 21882294
dgv1199n71 CNV Loss 21882294
nsv468609 CNV Loss 19166990
nsv469963 CNV Loss 18288195

Variation tolerance for NUDT8 Gene

Residual Variation Intolerance Score: 46.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.88; 48.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUDT8 Gene

HapMap Linkage Disequilibrium report
NUDT8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT8 Gene

Disorders for NUDT8 Gene

Relevant External Links for NUDT8

Genetic Association Database (GAD)
NUDT8
Human Genome Epidemiology (HuGE) Navigator
NUDT8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUDT8

No disorders were found for NUDT8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUDT8 Gene

Publications for NUDT8 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. The mouse Nudt7 gene encodes a peroxisomal nudix hydrolase specific for coenzyme A and its derivatives. (PMID: 11415433) Gasmi L. … McLennan A.G. (Biochem. J. 2001) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang A.G. … Kim N.S. (Biochem. Biophys. Res. Commun. 2006) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for NUDT8 Gene

Sources for NUDT8 Gene

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