Aliases for NUDT7 Gene
External Ids for NUDT7 Gene
The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
GeneCards Summary for NUDT7 Gene
NUDT7 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 7) is a Protein Coding gene. Among its related pathways are Peroxisome. GO annotations related to this gene include receptor binding and manganese ion binding. An important paralog of this gene is NUDT8.
UniProtKB/Swiss-Prot for NUDT7 Gene
Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3,5-ADP and the corresponding 4-phosphopantetheine derivative as products. CoA into 3,5-ADP and 4-phosphopantetheine. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5-triphosphates, nucleoside 5-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (By similarity).