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Aliases for NUDT7 Gene

Aliases for NUDT7 Gene

  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 7 2 3
  • Nucleoside Diphosphate-Linked Moiety X Motif 7 4
  • Nudix Motif 7 4
  • EC 3.6.1.- 4

External Ids for NUDT7 Gene

Summaries for NUDT7 Gene

Entrez Gene Summary for NUDT7 Gene

  • The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for NUDT7 Gene

NUDT7 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 7) is a Protein Coding gene. Among its related pathways are Peroxisome. GO annotations related to this gene include receptor binding and manganese ion binding. An important paralog of this gene is NUDT8.

UniProtKB/Swiss-Prot for NUDT7 Gene

  • Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3,5-ADP and the corresponding 4-phosphopantetheine derivative as products. CoA into 3,5-ADP and 4-phosphopantetheine. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5-triphosphates, nucleoside 5-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT7 Gene

Genomics for NUDT7 Gene

Genomic Location for NUDT7 Gene

Start:
77,722,492 bp from pter
End:
77,742,260 bp from pter
Size:
19,769 bases
Orientation:
Plus strand

Genomic View for NUDT7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUDT7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT7 Gene

Regulatory Elements for NUDT7 Gene

Proteins for NUDT7 Gene

  • Protein details for NUDT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C024-NUDT7_HUMAN
    Recommended name:
    Peroxisomal coenzyme A diphosphatase NUDT7
    Protein Accession:
    P0C024
    Secondary Accessions:
    • B4DLE5
    • H3BUB8

    Protein attributes for NUDT7 Gene

    Size:
    238 amino acids
    Molecular mass:
    26942 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NUDT7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUDT7 Gene

Proteomics data for NUDT7 Gene at MOPED

Post-translational modifications for NUDT7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NUDT7 Gene

Domains for NUDT7 Gene

Gene Families for NUDT7 Gene

HGNC:
  • NUDT :Nudix motif containing

Protein Domains for NUDT7 Gene

UniProtKB/Swiss-Prot:

NUDT7_HUMAN
Domain:
  • Contains 1 nudix hydrolase domain.:
    • P0C024
Family:
  • Belongs to the Nudix hydrolase family. PCD1 subfamily.:
    • P0C024
genes like me logo Genes that share domains with NUDT7: view

Function for NUDT7 Gene

Molecular function for NUDT7 Gene

UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by fluoride.
UniProtKB/Swiss-Prot Function: Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3,5-ADP and the corresponding 4-phosphopantetheine derivative as products. CoA into 3,5-ADP and 4-phosphopantetheine. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5-triphosphates, nucleoside 5-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (By similarity).

Enzyme Numbers (IUBMB) for NUDT7 Gene

Gene Ontology (GO) - Molecular Function for NUDT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0003674 molecular_function ND --
GO:0003986 acetyl-CoA hydrolase activity ISS --
GO:0005102 receptor binding IPI 20178365
GO:0016787 hydrolase activity --
genes like me logo Genes that share ontologies with NUDT7: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NUDT7 Gene

Localization for NUDT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDT7 Gene

Peroxisome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUDT7 Gene COMPARTMENTS Subcellular localization image for NUDT7 gene
Compartment Confidence
peroxisome 4
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NUDT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005777 peroxisome ISS --
genes like me logo Genes that share ontologies with NUDT7: view

Pathways for NUDT7 Gene

SuperPathways for NUDT7 Gene

Superpath Contained pathways
1 Peroxisome
genes like me logo Genes that share pathways with NUDT7: view

Pathways by source for NUDT7 Gene

1 KEGG pathway for NUDT7 Gene

Interacting Proteins for NUDT7 Gene

Gene Ontology (GO) - Biological Process for NUDT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0009132 nucleoside diphosphate metabolic process IEA --
GO:0015938 coenzyme A catabolic process ISS --
GO:0046356 acetyl-CoA catabolic process ISS --
GO:0050873 brown fat cell differentiation IEA --
genes like me logo Genes that share ontologies with NUDT7: view

Compounds for NUDT7 Gene

(38) HMDB Compounds for NUDT7 Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with NUDT7: view

Transcripts for NUDT7 Gene

mRNA/cDNA for NUDT7 Gene

(6) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NUDT7 Gene

Nudix (nucleoside diphosphate linked moiety X)-type motif 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: -
SP2: - -
SP3: - -
SP4: - - -

Relevant External Links for NUDT7 Gene

GeneLoc Exon Structure for
NUDT7
ECgene alternative splicing isoforms for
NUDT7

Expression for NUDT7 Gene

mRNA expression in normal human tissues for NUDT7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NUDT7 Gene

This gene is overexpressed in Liver (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUDT7 Gene

SOURCE GeneReport for Unigene cluster for NUDT7 Gene Hs.282665

mRNA Expression by UniProt/SwissProt for NUDT7 Gene

P0C024-NUDT7_HUMAN
Tissue specificity: Expressed in liver, kidney, pancreas, pituitary, small intestine, spleen, heart and placenta. Weakly expressed in brain.
genes like me logo Genes that share expressions with NUDT7: view

Orthologs for NUDT7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUDT7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUDT7 36
  • 99.44 (n)
  • 99.58 (a)
NUDT7 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NUDT7 36
  • 76.19 (n)
  • 68.49 (a)
NUDT7 37
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUDT7 36
  • 80.53 (n)
  • 71.85 (a)
NUDT7 37
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nudt7 36
  • 74.74 (n)
  • 67.84 (a)
Nudt7 16
Nudt7 37
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NUDT7 37
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUDT7 37
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102555567 36
  • 72.78 (n)
  • 65.5 (a)
chicken
(Gallus gallus)
Aves NUDT7 36
  • 56.93 (n)
  • 50 (a)
NUDT7 37
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUDT7 37
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nudt7 36
  • 54.67 (n)
  • 48.89 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100329471 36
  • 50.32 (n)
  • 42.72 (a)
NUDT7 37
  • 39 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ndx-8 37
  • 27 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PCD1 39
thale cress
(Arabidopsis thaliana)
eudicotyledons NUDT11 36
  • 46.44 (n)
  • 36.52 (a)
rice
(Oryza sativa)
Liliopsida Os05g0209400 36
  • 46.79 (n)
  • 37.27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 32 (a)
OneToOne
Species with no ortholog for NUDT7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUDT7 Gene

ENSEMBL:
Gene Tree for NUDT7 (if available)
TreeFam:
Gene Tree for NUDT7 (if available)

Paralogs for NUDT7 Gene

Paralogs for NUDT7 Gene

genes like me logo Genes that share paralogs with NUDT7: view

Variants for NUDT7 Gene

Sequence variations from dbSNP and Humsavar for NUDT7 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs160197 -- 77,726,260(+) aatat(C/T)agtaa intron-variant
rs186305 -- 77,735,750(-) TACTG(A/G)ACTTC intron-variant
rs308924 -- 77,736,453(-) TGTAT(C/T)ACAGA intron-variant
rs308927 -- 77,734,943(-) tttaa(C/T)acatt intron-variant
rs308928 -- 77,732,955(-) TGTCT(C/T)ACCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUDT7 Gene

Variant ID Type Subtype PubMed ID
nsv521833 CNV Loss 19592680
nsv457542 CNV Gain 19166990
nsv471098 CNV Gain 18288195
nsv457543 CNV Gain 19166990
esv2714736 CNV Deletion 23290073

Relevant External Links for NUDT7 Gene

HapMap Linkage Disequilibrium report
NUDT7
Human Gene Mutation Database (HGMD)
NUDT7

Disorders for NUDT7 Gene

Relevant External Links for NUDT7

Genetic Association Database (GAD)
NUDT7
Human Genome Epidemiology (HuGE) Navigator
NUDT7
genes like me logo Genes that share disorders with NUDT7: view

No data available for UniProtKB/Swiss-Prot for NUDT7 Gene

Publications for NUDT7 Gene

  1. The mouse Nudt7 gene encodes a peroxisomal nudix hydrolase specific for coenzyme A and its derivatives. (PMID: 11415433) Gasmi L. … McLennan A.G. (Biochem. J. 2001) 2 3 4 23
  2. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 3 4
  3. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PMID: 19844255) Dastani Z. … Genest J. (Eur. J. Hum. Genet. 2010) 3 49
  4. A proteome-wide perspective on peroxisome targeting signal 1(PTS1)- Pex5p affinities. (PMID: 20178365) Ghosh D. … Berg J.M. (J. Am. Chem. Soc. 2010) 3
  5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3

Products for NUDT7 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate NUDT7
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for NUDT7
    • Block miRNA regulation of NUDT7 using miScript Target Protectors

    Sources for NUDT7 Gene

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