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Aliases for NUDT6 Gene

Aliases for NUDT6 Gene

  • Nudix Hydrolase 6 2 3 5
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 6 2 3
  • Antisense Basic Fibroblast Growth Factor 3 4
  • FGF2AS 3 4
  • Nucleoside Diphosphate-Linked Moiety X Motif 6 3
  • Nudix Motif 6 4
  • Protein GFG 4
  • EC 3.6.1.- 4
  • ASFGF2 3
  • FGF-AS 3
  • GFG-1 3
  • GFG1 3

External Ids for NUDT6 Gene

Previous GeneCards Identifiers for NUDT6 Gene

  • GC04M124726
  • GC04M124093
  • GC04M124207
  • GC04M124272
  • GC04M124171
  • GC04M123814
  • GC04M119540

Summaries for NUDT6 Gene

Entrez Gene Summary for NUDT6 Gene

  • This gene overlaps and lies on the opposite strand from FGF2 gene, and is thought to be the FGF2 antisense gene. The two genes are independently transcribed, and their expression shows an inverse relationship, suggesting that this antisense transcript may regulate FGF2 expression. This gene has also been shown to have hormone-regulatory and antiproliferative actions in the pituitary that are independent of FGF2 expression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for NUDT6 Gene

NUDT6 (Nudix Hydrolase 6) is a Protein Coding gene. Diseases associated with NUDT6 include Prostatic Adenoma and Bone Fracture. Among its related pathways are Activation of cAMP-Dependent PKA and GPCR Pathway. GO annotations related to this gene include hydrolase activity and growth factor activity.

UniProtKB/Swiss-Prot for NUDT6 Gene

  • May contribute to the regulation of cell proliferation.

Gene Wiki entry for NUDT6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT6 Gene

Genomics for NUDT6 Gene

Regulatory Elements for NUDT6 Gene

Enhancers for NUDT6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F122897 1 Ensembl ENCODE 22 +24.3 24253 2.9 ZNF362 JUN BHLHE40 CEBPB USF2 SIN3A EP300 RFX5 SREBF1 JUND NUDT6 FGF2 SPATA5 ENSG00000273007
GH04F122762 1.6 FANTOM5 Ensembl ENCODE 10.9 +158.5 158499 4.6 HDAC1 ELF3 TBP DMAP1 GTF3C2 GATA2 FOS CREM SMARCA5 ZBTB2 SPATA5 CETN4P FGF2 ENSG00000237868 BBS12 EXOSC9 NUDT6 CCNA2 LOC727709 RPL34P12
GH04F122795 1.5 FANTOM5 Ensembl ENCODE 9.9 +124.9 124853 4.5 TBP HDAC1 ZBTB40 RAD21 ZNF366 CEBPB ZEB2 REST ZNF518A POLR2H FGF2 NUDT6 SPATA5 IL21-AS1 CETN4P SPRY1 RPL34P12 LOC727709
GH04F122781 1.4 FANTOM5 Ensembl ENCODE 10.5 +139.3 139269 4.2 GTF2F1 TBP JUN TEAD4 MAX RFX5 TEAD3 ZNF316 POLR2A RCOR1 FGF2 NUDT6 SPATA5 CETN4P SPRY1 RPL34P12 LOC727709
GH04F122920 1.1 ENCODE 12.6 +0.3 347 3.8 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 ETS1 ELK1 NUDT6 FGF2 ENSG00000273007
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NUDT6 on UCSC Golden Path with GeneCards custom track

Promoters for NUDT6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001434821 204 3201 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 ETS1 ELK1

Genomic Location for NUDT6 Gene

Chromosome:
4
Start:
122,888,697 bp from pter
End:
122,923,004 bp from pter
Size:
34,308 bases
Orientation:
Minus strand

Genomic View for NUDT6 Gene

Genes around NUDT6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDT6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDT6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT6 Gene

Proteins for NUDT6 Gene

  • Protein details for NUDT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53370-NUDT6_HUMAN
    Recommended name:
    Nucleoside diphosphate-linked moiety X motif 6
    Protein Accession:
    P53370
    Secondary Accessions:
    • A8K756
    • O95097
    • Q9UQD9

    Protein attributes for NUDT6 Gene

    Size:
    316 amino acids
    Molecular mass:
    35679 Da
    Quaternary structure:
    • Monomer and homodimer.
    Miscellaneous:
    • This protein is coded from a FGF2 (BFGF) gene antisense transcript.

    Three dimensional structures from OCA and Proteopedia for NUDT6 Gene

    Alternative splice isoforms for NUDT6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUDT6 Gene

Post-translational modifications for NUDT6 Gene

  • Ubiquitination at Lys 76
  • Modification sites at PhosphoSitePlus

Other Protein References for NUDT6 Gene

No data available for DME Specific Peptides for NUDT6 Gene

Domains & Families for NUDT6 Gene

Gene Families for NUDT6 Gene

Suggested Antigen Peptide Sequences for NUDT6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P53370

UniProtKB/Swiss-Prot:

NUDT6_HUMAN :
  • Contains 1 nudix hydrolase domain.
  • Belongs to the Nudix hydrolase family.
Domain:
  • Contains 1 nudix hydrolase domain.
Family:
  • Belongs to the Nudix hydrolase family.
genes like me logo Genes that share domains with NUDT6: view

Function for NUDT6 Gene

Molecular function for NUDT6 Gene

GENATLAS Biochemistry:
nudix (nucleoside diphosphate linked moiety X)-type motif 6,hydrolase,antisense transcript of FGF2,coexpressed with FGF2 in many tissues,and potentially regulator of FGF2 expression,putative mouse cleaning gene whose functions is to cleanse the cell of potentially deleterious endogenous metabolites and to modulate the accumulation of intermediates in biochemical pathways
UniProtKB/Swiss-Prot Function:
May contribute to the regulation of cell proliferation.

Enzyme Numbers (IUBMB) for NUDT6 Gene

Gene Ontology (GO) - Molecular Function for NUDT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008083 growth factor activity TAS 7984147
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with NUDT6: view
genes like me logo Genes that share phenotypes with NUDT6: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NUDT6 Gene

Localization for NUDT6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDT6 Gene

Cytoplasm. Nucleus. Mitochondrion. Note=Subcellular location may vary between isoforms.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUDT6 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytoskeleton 3

Gene Ontology (GO) - Cellular Components for NUDT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with NUDT6: view

Pathways & Interactions for NUDT6 Gene

genes like me logo Genes that share pathways with NUDT6: view

Interacting Proteins for NUDT6 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000306070%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000306070 P53370-NUDT6_HUMAN for NUDT6 Gene via STRING IID

Gene Ontology (GO) - Biological Process for NUDT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with NUDT6: view

No data available for SIGNOR curated interactions for NUDT6 Gene

Drugs & Compounds for NUDT6 Gene

(30) Drugs for NUDT6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(15) Additional Compounds for NUDT6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NUDT6: view

Transcripts for NUDT6 Gene

Unigene Clusters for NUDT6 Gene

Nudix (nucleoside diphosphate linked moiety X)-type motif 6:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT6 Gene

No ASD Table

Relevant External Links for NUDT6 Gene

GeneLoc Exon Structure for
NUDT6
ECgene alternative splicing isoforms for
NUDT6

Expression for NUDT6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NUDT6 Gene

Protein differential expression in normal tissues from HIPED for NUDT6 Gene

This gene is overexpressed in Gallbladder (27.6), Liver (10.7), Kidney (10.2), and Heart (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NUDT6 Gene



NURSA nuclear receptor signaling pathways regulating expression of NUDT6 Gene:

NUDT6

SOURCE GeneReport for Unigene cluster for NUDT6 Gene:

Hs.558459

mRNA Expression by UniProt/SwissProt for NUDT6 Gene:

P53370-NUDT6_HUMAN
Tissue specificity: Detected in liver, kidney and esophagus (at protein level). Ubiquitous.
genes like me logo Genes that share expression patterns with NUDT6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for NUDT6 Gene

Orthologs for NUDT6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUDT6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUDT6 34 35
  • 99.37 (n)
cow
(Bos Taurus)
Mammalia NUDT6 34 35
  • 90.2 (n)
dog
(Canis familiaris)
Mammalia NUDT6 34 35
  • 86.58 (n)
rat
(Rattus norvegicus)
Mammalia Nudt6 34
  • 79.83 (n)
mouse
(Mus musculus)
Mammalia Nudt6 34 16 35
  • 77.01 (n)
oppossum
(Monodelphis domestica)
Mammalia NUDT6 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUDT6 34 35
  • 75.93 (n)
lizard
(Anolis carolinensis)
Reptilia NUDT6 35
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nudt6 34
  • 69.01 (n)
Str.20390 34
zebrafish
(Danio rerio)
Actinopterygii nudt6 34 35
  • 60.73 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8128 36 34 35
  • 45.26 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012857 34
  • 43.21 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons NUDT8 34
  • 48.91 (n)
rice
(Oryza sativa)
Liliopsida Os04g0547900 34
  • 48.86 (n)
Species where no ortholog for NUDT6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUDT6 Gene

ENSEMBL:
Gene Tree for NUDT6 (if available)
TreeFam:
Gene Tree for NUDT6 (if available)

Paralogs for NUDT6 Gene

No data available for Paralogs for NUDT6 Gene

Variants for NUDT6 Gene

Sequence variations from dbSNP and Humsavar for NUDT6 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs552219028 Pathogenic 122,923,143(+) TGACC(A/C/G/T)TGTCT nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs1048201 -- 122,893,153(+) GTTGC(C/T)GAATA reference, missense, utr-variant-3-prime
rs10518408 -- 122,924,398(+) TCCTG(A/G)TGTGG intron-variant, upstream-variant-2KB
rs11098674 -- 122,910,138(+) AAACA(C/T)AGTTT intron-variant
rs11098675 -- 122,911,621(+) GAAAT(A/G)TGTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUDT6 Gene

Variant ID Type Subtype PubMed ID
esv3894022 CNV gain 25118596
esv3602036 CNV loss 21293372
esv2657447 CNV deletion 23128226

Variation tolerance for NUDT6 Gene

Residual Variation Intolerance Score: 71.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.58; 82.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUDT6 Gene

Human Gene Mutation Database (HGMD)
NUDT6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUDT6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT6 Gene

Disorders for NUDT6 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NUDT6 Gene - From: GeneCards

Disorder Aliases PubMed IDs
prostatic adenoma
  • adenoma - prostate
bone fracture
brain glioma
  • lower grade glioma
- elite association - COSMIC cancer census association via MalaCards
Search NUDT6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NUDT6

Genetic Association Database (GAD)
NUDT6
Human Genome Epidemiology (HuGE) Navigator
NUDT6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUDT6
genes like me logo Genes that share disorders with NUDT6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUDT6 Gene

Publications for NUDT6 Gene

  1. Identification and characterization of an antisense RNA transcript (gfg) from the human basic fibroblast growth factor gene. (PMID: 7984147) Murphy P.R. … Knee R.S. (Mol. Endocrinol. 1994) 2 3 4 22 64
  2. The endogenous fibroblast growth factor-2 antisense gene product regulates pituitary cell growth and hormone production. (PMID: 11266510) Asa S.L. … Ezzat S. (Mol. Endocrinol. 2001) 3 4 22 64
  3. Characterization of the promoter for the human antisense fibroblast growth factor-2 gene; regulation by Ets in Jurkat T cells. (PMID: 10022609) Gagnon M.L. … Klagsbrun M. (J. Cell. Biochem. 1999) 2 3 4 64
  4. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P. … Inskip P.D. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 46 64
  5. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S. … Kang D. (Hum. Immunol. 2010) 3 46 64

Products for NUDT6 Gene

Sources for NUDT6 Gene

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