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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NUDT6 Gene

protein-coding   GIFtS: 57
GCID: GC04M123814

Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif...

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 61 2     GFG12
Antisense Basic Fibroblast Growth Factor2 3     Nucleoside Diphosphate-Linked Moiety X Motif 62
FGF2AS2 3     EC 3.6.1.-3
ASFGF22     Nudix Motif 63
FGF-AS2     Protein GFG3
GFG-12     

External Ids:    HGNC: 80531   Entrez Gene: 111622   Ensembl: ENSG000001709177   OMIM: 6062615   UniProtKB: P533703   

Export aliases for NUDT6 gene to outside databases

Previous GC identifers: GC04M124726 GC04M124093 GC04M124207 GC04M124272 GC04M124171 GC04M119540


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NUDT6 Gene:
This gene overlaps and lies on the opposite strand from FGF2 gene, and is thought to be the FGF2 antisense gene.
The two genes are independently transcribed, and their expression shows an inverse relationship, suggesting that
this antisense transcript may regulate FGF2 expression. This gene has also been shown to have hormone-regulatory
and antiproliferative actions in the pituitary that are independent of FGF2 expression. Alternatively spliced
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for NUDT6 Gene: 
NUDT6 (nudix (nucleoside diphosphate linked moiety X)-type motif 6) is a protein-coding gene. Diseases associated with NUDT6 include gingival overgrowth, and embryonal cancer, and among its related super-pathways are Rac1 Pathway and Ras Pathway. GO annotations related to this gene include hydrolase activity and growth factor activity.

UniProtKB/Swiss-Prot: NUDT6_HUMAN, P53370
Function: May contribute to the regulation of cell proliferation

Gene Wiki entry for NUDT6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NUDT6 gene promoter:
         AP-1   STAT3   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNUDT6 promoter sequence
   Search SABiosciences Chromatin IP Primers for NUDT6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUDT6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q26   Ensembl cytogenetic band:  4q28.1   HGNC cytogenetic band: 4q26

NUDT6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUDT6 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M123814:  view genomic region     (about GC identifiers)

Start:
123,813,730 bp from pter      End:
123,844,123 bp from pter
Size:
30,394 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NUDT6_HUMAN, P53370 (See protein sequence)
Recommended Name: Nucleoside diphosphate-linked moiety X motif 6  
Size: 316 amino acids; 35679 Da
Subunit: Monomer and homodimer (Probable)
Subcellular location: Cytoplasm. Nucleus. Mitochondrion. Note=Subcellular location may vary between isoforms
Miscellaneous: This protein is coded from a FGF2 (BFGF) gene antisense transcript
Caution: The rat protein was reported to play a role in DNA repair (PubMed:9406864), based on its ability to
complement E.coli deficient in the DNA repair enzyme mutT that hydrolyzes oxidized guanine nucleotides.
PubMed:17569023 found no such activity, neither for the human nor the rat protein
2 PDB 3D structures from and Proteopedia for NUDT6:
3FXT (3D)        3H95 (3D)    
Secondary accessions: A8K756 O95097 Q9UQD9
Alternative splicing: 2 isoforms:  P53370-1   P53370-2   

Explore the universe of human proteins at neXtProt for NUDT6: NX_P53370

Explore proteomics data for NUDT6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P53370

  • NUDT6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NUDT6 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_009014.2  NP_932158.1  

    ENSEMBL proteins: 
     ENSP00000420843   ENSP00000306070   ENSP00000344011   ENSP00000422698   ENSP00000423745  
     ENSP00000424117  

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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for NUDT6 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005634nucleus IEA--
    GO:0005739mitochondrion IEA--

    NUDT6 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    NUDT: Nudix motif containing

    4 InterPro protein domains:
     IPR015797 NUDIX_hydrolase_dom-like
     IPR020084 NUDIX_hydrolase_CS
     IPR003293 Nudix_hydrolase6-like
     IPR000086 NUDIX_hydrolase_dom

    Graphical View of Domain Structure for InterPro Entry P53370

    ProtoNet protein and cluster: P53370

    2 Blocks protein domains:
    IPB000086 NUDIX hydrolase
    IPB003293 Anti-sense to fibroblast growth factor protein GFG signature


    UniProtKB/Swiss-Prot: NUDT6_HUMAN, P53370
    Similarity: Belongs to the Nudix hydrolase family
    Similarity: Contains 1 nudix hydrolase domain


    NUDT6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NUDT6_HUMAN, P53370
    Function: May contribute to the regulation of cell proliferation

         Genatlas biochemistry entry for NUDT6:
    nudix (nucleoside diphosphate linked moiety X)-type motif 6,hydrolase,antisense transcript of FGF2,coexpressed
    with FGF2 in many tissues,and potentially regulator of FGF2 expression,putative mouse cleaning gene whose
    functions is to cleanse the cell of potentially deleterious endogenous metabolites and to modulate the
    accumulation of intermediates in biochemical pathways

         Enzyme Number (IUBMB): EC 3.6.1.-1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008083growth factor activity TAS7984147
    GO:0016787hydrolase activity IEA--
         
    NUDT6 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NUDT6:
     Decreased homologous recombina 

    Animal Models:
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NUDT6 About   (see all 12)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    2GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    3Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    4Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    5TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JAK-STAT Pathway0.57
    MAPK Family Pathway0.60
    JNK Pathway0.51

    5/54 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NUDT6 (see all 54)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NUDT6

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5/27 Interacting proteins for NUDT6 (P533703 ENSP000003060704) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARHGAP1Q079603I2D: score=3 
    BUD13Q9BRD03I2D: score=3 
    CADP277083I2D: score=3 
    COG8Q96MW53I2D: score=3 
    COPS3Q9UNS23I2D: score=3 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    NUDT6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NUDT6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NUDT6

    10/45 Novoseek inferred chemical compound relationships for NUDT6 gene (see all 45)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    saporin 35.3 5 8630880 (1)
    suramin 30.8 9 15840333 (6), 10398280 (1), 7678932 (1), 1984091 (1)
    5-methylthioadenosine 29.3 3 8395923 (2)
    17beta-hydroxysteroid 28.6 1 1338722 (1)
    matrigel 26.9 4 10676661 (1), 11027671 (1), 16323075 (1), 18468232 (1)
    famotidine 13.6 4 8774986 (2), 7594320 (2)
    lansoprazole 11 6 8774986 (3), 7594320 (3)
    ribonucleic acid 5.39 3 7815139 (1), 8559302 (1)
    iron 4.43 2 8478396 (1), 7762443 (1)
    dbc-amp 3.72 2 8395923 (1)

    Search CenterWatch for drugs/clinical trials and news about NUDT6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NUDT6 gene (2 alternative transcripts): 
    NM_007083.4  NM_198041.2  

    Unigene Cluster for NUDT6:

    Nudix (nucleoside diphosphate linked moiety X)-type motif 6
    Hs.558459  [show with all ESTs]
    Unigene Representative Sequence: BI560302
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000512116 ENST00000304430(uc003iew.3) ENST00000339154(uc003iex.3)
    ENST00000503370 ENST00000510735 ENST00000502270 ENST00000513517
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Additional mRNA sequence: 

    AF019632.2 AF019633.2 AK291871.1 AK294450.1 BC009842.2 

    5 DOTS entries:

    DT.100712482  DT.75103181  DT.100021932  DT.416573  DT.75181099 

    24/76 AceView cDNA sequences (see all 76):

    AI417721 AI420564 BG214454 AA226913 AI479705 BM970451 AA953379 NM_007083 
    BG197239 NM_198041 BQ434362 AI492978 BG200726 BG197240 BG190638 BU619706 
    AI401057 CB141532 AA281223 BC009842 AF019632 BQ716561 CA392430 CA397958 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NUDT6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACATTTTAA
    NUDT6 Expression
    About this image


    See NUDT6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NUDT6

    SOURCE GeneReport for Unigene cluster: Hs.558459

    UniProtKB/Swiss-Prot: NUDT6_HUMAN, P53370
    Tissue specificity: Detected in liver, kidney and esophagus (at protein level). Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Array including NUDT6: 
              Mesenchymal Stem Cell in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NUDT6 gene from 8/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nudt61 , 5 nudix (nucleoside diphosphate linked moiety X)-type more1, 5 77.01(n)1
    75.91(a)1
      3 (18.46 cM)5
    2292281  NM_153561.21  NP_705789.11 
     374049105 
    chicken
    (Gallus gallus)
    Aves NUDT61 nudix (nucleoside diphosphate linked moiety X)-type more 71.35(n)
    76.6(a)
      422666  XM_003641202.1  XP_003641250.1 
    lizard
    (Anolis carolinensis)
    Reptilia NUDT66
    nudix (nucleoside diphosphate linked moiety X)-typ...
    65(a)
    1 ↔ 1
    5(138549727-138571846)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.203902 Transcribed sequence with weak similarity to protein more 73.98(n)    BX708145.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nudt61 nudix (nucleoside diphosphate linked moiety X)-type more 61.3(n)
    63.22(a)
      100037370  NM_001089522.1  NP_001082991.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG81283   -- 38(a)     --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons NUDT21 nudix hydrolase 2 49.39(n)
    38.74(a)
      834816  NM_124139.3  NP_568687.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g06343001 hypothetical protein 51.61(n)
    40.1(a)
      4341595  NM_001064671.1  NP_001058136.1 


    ENSEMBL Gene Tree for NUDT6 (if available)
    TreeFam Gene Tree for NUDT6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/734 SNPs in NUDT6 are shown (see all 734)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs723624521,2
    C--119549867(+) GTATA-/ATTG  
            
    TTGGG
    2 -- int10--------
    rs2000476551,2
    C--119556673(+) CCAGC-/TTTTTT 2 -- int10--------
    rs1420268401,2
    C--119558190(+) CTTCT-/GAAACC 2 -- int10--------
    rs1112500291,2
    C,F--123599184(+) TTTAAT/CGGCCA 2 -- ds50012Minor allele frequency- C:0.00NS EU 1863
    rs1863127881,2
    --123599272(+) ATAGCC/TCAGTT 2 -- ds50010--------
    rs38041561,2
    C,F,H--123599281(+) TTTGGA/GTAATT 2 -- ds50018Minor allele frequency- G:0.00EA NS NA 1954
    rs456277361,2
    C,F--123599345(+) GAAAAA/CTAACA 2 -- ds50013Minor allele frequency- C:0.03NS NA 838
    rs2001670491,2
    --123599573(+) CATTCA/GTTAGT 2 -- ut310--------
    rs1481233531,2
    C--123599750(+) AGCAGC/TAGCCT 4 L syn10--------
    rs456066401,2
    C,F--123599790(+) TTTCAG/ATCTTC 4 /T /I mis12Minor allele frequency- A:0.00NA EU 5873

    HapMap Linkage Disequilibrium report for NUDT6 (123813730 - 123844123 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NUDT6:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2657447CNV Deletion23128226
    nsv879867CNV Gain21882294


    Human Gene Mutation Database (HGMD): NUDT6
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NUDT6
    DNA2.0 Custom Variant and Variant Library Synthesis for NUDT6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606261    OMIM disorders: --

    20/72 diseases for NUDT6 (see all 72):    About MalaCards
    gingival overgrowth    embryonal cancer    pulmonary capillary hemangiomatosis    gastric ulcer
    exfoliation syndrome    moyamoya disease    bone fracture    head injury
    bladder carcinoma    proliferative vitreoretinopathy    benign tumors    esophageal adenocarcinoma
    gingivitis    oral lichen planus    noonan syndrome    multiple endocrine neoplasia
    diabetic neuropathy    ischemic heart disease    myopia    chordoma


    NUDT6 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/57 Novoseek inferred disease relationships for NUDT6 gene (see all 57)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    skin ulcer 36.5 1 19638336 (1)
    scars hypertrophic 36.2 3 16199295 (1), 17971006 (1), 8860952 (1)
    vitreoretinopathy proliferative 33.9 2 12579721 (1)
    glioma 29.2 22 8559302 (4), 7984147 (2), 17306451 (2), 18799025 (2) (see all 8)
    gingival overgrowth 26.9 6 9477019 (4)
    retinal degeneration 23.8 1 12675490 (1)
    ulcer 20.9 25 19638336 (5), 15086596 (2), 7594320 (2), 7948825 (1) (see all 8)
    pituitary tumors 14.8 3 11266510 (2)
    tumors 13.5 81 8146294 (5), 9625854 (4), 9149261 (3), 16278388 (3) (see all 37)
    moyamoya disease 12.5 6 8893713 (3), 7694557 (1)

    Genetic Association Database (GAD): NUDT6
    Human Genome Epidemiology (HuGE) Navigator: NUDT6 (10 documents)

    Export disorders for NUDT6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NUDT6 gene, integrated from 9 sources (see all 346):
    (articles sorted by number of sources associating them with NUDT6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of an antisense RNA transcript (gfg) from the human basic fibroblast growth factor gene. (PubMed id 7984147)1, 2, 3, 9 Murphy P.R. and Knee R.S. (1994)
    2. Characterization of the promoter for the human antisense fibroblast growth factor-2 gene; regulation by Ets in Jurkat T cells. (PubMed id 10022609)1, 2, 3 Gagnon M.L.... Klagsbrun M. (1999)
    3. The endogenous fibroblast growth factor-2 antisense gene product regulates pituitary cell growth and hormone production. (PubMed id 11266510)1, 2, 9 Asa S.L.... Ezzat S. (2001)
    4. Alternative splicing of the FGF antisense gene: differential subcellular localization in human tissues and esophageal adenocarcinoma. (PubMed id 17569023)1, 2, 9 Zhang S.C.... Murphy P.R. (2007)
    5. Association study between keratinocyte-derived growth factor gene polymorphisms and susceptibility to vitiligo vulgaris in a Taiwanese population: potential involvement of stem cell factor. (PubMed id 19416273)1, 4, 9 Lan C.C....Yu H.S. (2009)
    6. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    7. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    8. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    9. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    10. Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence. (PubMed id 19054571)1, 4 GregA^rio S.P....Dias-Neto E. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11162 HGNC: 8053 AceView: NUDT6 Ensembl:ENSG00000170917 euGenes: HUgn11162
    ECgene: NUDT6 H-InvDB: NUDT6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NUDT6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NUDT6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NUDT6 gene:
    Search GeneIP for patents involving NUDT6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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