Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NUDT6 Gene

protein-coding GIFtS: 54
GCID: GC04M123814

nudix (nucleoside diphosphate linked moiety X)-type motif...

Explore 75 diseases affiliated with
NUDT6 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 6¹ ²		GFG-1²
FGF2AS¹ ² ³		GFG1²
FGF-AS¹ ²		Nucleoside Diphosphate-Linked Moiety X Motif 6²
Antisense Basic Fibroblast Growth Factor² ³		EC 3.6.1.-³
Gfg¹		Nudix Motif 6³
Gfg-1¹		Protein GFG³
ASFGF2²

External Ids:	HGNC: 8053¹	Entrez Gene: 11162²	Ensembl: ENSG00000170917⁷	OMIM: 606261⁵	UniProtKB: P53370³

Export aliases for NUDT6 gene to outside databases

Previous GC identifers: GC04M124726 GC04M124093 GC04M124207 GC04M124272 GC04M124171 GC04M119540

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NUDT6:

This gene overlaps and lies on the opposite strand from FGF2 gene, and is thought to be the FGF2 antisense gene. The

two genes are independently transcribed, and their expression shows an inverse relationship, suggesting that this

antisense transcript may regulate FGF2 expression. This gene has also been shown to have hormone-regulatory and

antiproliferative actions in the pituitary that are independent of FGF2 expression. Alternatively spliced transcript

variants encoding different isoforms have been found for this gene. (provided by RefSeq, Oct 2011)

UniProtKB/Swiss-Prot: NUDT6_HUMAN, P53370

Function: May contribute to the regulation of cell proliferation

Gene Wiki entry for NUDT6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_016354.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NUDT6 gene promoter:
AP-1 STAT3 ATF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NUDT6 promoter sequence

Search SABiosciences Chromatin IP Primers for NUDT6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUDT6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q26 Ensembl cytogenetic band: 4q28.1 HGNC cytogenetic band: 4q26

NUDT6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUDT6 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M123814: view genomic region (about GC identifiers)

Start:	123,813,730 bp from pter	End:	123,844,123 bp from pter
Size:	30,394 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NUDT6_HUMAN, P53370 (See protein sequence)

Recommended Name: Nucleoside diphosphate-linked moiety X motif 6

Size: 316 amino acids; 35679 Da

Subunit: Monomer and homodimer (Probable)

Subcellular location: Cytoplasm. Nucleus. Mitochondrion. Note=Subcellular location may vary between isoforms

Miscellaneous: This protein is coded from a FGF2 (BFGF) gene antisense transcript

Caution: The rat protein was reported to play a role in DNA repair (PubMed:9406864), based on its ability to complement

E.coli deficient in the DNA repair enzyme mutT that hydrolyzes oxidized guanine nucleotides. PubMed:17569023 found no

such activity, neither for the human nor the rat protein

2 PDB 3D structures from and Proteopedia for NUDT6:

3FXT (3D)

3H95 (3D)

Secondary accessions: A8K756 O95097 Q9UQD9

Alternative splicing: 2 isoforms: P53370-1 P53370-2

Explore the universe of human proteins at neXtProt for NUDT6: NX_P53370

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P53370

NUDT6 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_009014.2 NP_932158.1

ENSEMBL proteins:

ENSP00000420843 ENSP00000306070 ENSP00000344011 ENSP00000422698 ENSP00000423745

ENSP00000424117

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: NUDT6 OriGene Protein Over-expression Lysate (see all 2): NUDT6 OriGene Custom Protein Services for NUDT6
	GenScript Custom Purified and Recombinant Proteins Services for NUDT6
	Novus Biologicals NUDT6 Protein Novus Biologicals NUDT6 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NUDT6

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005634	nucleus	IEA	--
GO:0005739	mitochondrion	IEA	--

NUDT6 for ontologies About GeneDecksing

NUDT6 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies (see all 10): NUDT6 OriGene Custom Antibody Services for NUDT6
	GenScript Custom Superior Antibodies Services for NUDT6
	Novus Biologicals NUDT6 Antibodies
	Abcam antibodies for NUDT6
	Uscn Antibodies for NUDT6
	ThermoFisher Antibodies for NUDT6

Assay Products for NUDT6:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NUDT6
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NUDT6

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NUDT6 for domains About GeneDecksing

4 InterPro domains/families:

IPR015797 NUDIX_hydrolase_dom-like

IPR020084 NUDIX_hydrolase_CS

IPR003293 Nudix_hydrolase6-like

IPR000086 NUDIX_hydrolase_dom

Graphical View of Domain Structure for InterPro Entry P53370

ProtoNet protein and cluster: P53370

2 Blocks protein families:

IPB000086 NUDIX hydrolase

IPB003293 Anti-sense to fibroblast growth factor protein GFG signature

UniProtKB/Swiss-Prot: NUDT6_HUMAN, P53370

Similarity: Belongs to the Nudix hydrolase family

Similarity: Contains 1 nudix hydrolase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: NUDT6_HUMAN, P53370

Function: May contribute to the regulation of cell proliferation

Genatlas biochemistry entry for NUDT6:

nudix (nucleoside diphosphate linked moiety X)-type motif 6,hydrolase,antisense transcript of FGF2,coexpressed with

FGF2 in many tissues,and potentially regulator of FGF2 expression,putative mouse cleaning gene whose functions is to

cleanse the cell of potentially deleterious endogenous metabolites and to modulate the accumulation of intermediates

in biochemical pathways

Enzyme Number (IUBMB): EC 3.6.1.-¹

miRNA Products:		OriGene 3'-UTR Clone (see all 2): NUDT6 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NUDT6
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NUDT6
		SwitchGear 3'UTR luciferase reporter plasmid: NUDT6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NUDT6 (see all 7) OriGene shRNA RFP: NUDT6 OriGene siRNA: NUDT6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUDT6

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for NUDT6

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT6 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT6 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): NUDT6 (NM_007083)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUDT6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUDT6

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NUDT6
		Search LifeMap BioReagents cell lines for NUDT6

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT6

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008083	growth factor activity	TAS	7984147
GO:0016787	hydrolase activity	IEA	--

NUDT6 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for NUDT6:

Decreased homologous recombina

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptotic Pathways in Synovial Fibroblasts

8/14 pathways (see all 14)
Apoptotic Pathways in Synovial Fibroblasts	1.00	ERK5 Signaling	0.61
p53 Mediated Apoptosis	0.84	eIF2 Pathway	0.60
Mitochondrial Apoptosis	0.73	Rac1 Pathway	0.58
Telomerase Components in Cell Signaling	0.72	Nuclear Receptor Activation by Vitamin-A	0.57

GPCR Pathway

GPCR Pathway	1.00	Estrogen Pathway	0.55
Ras Pathway	0.62	Pancreatic Adenocarcinoma	0.55
Breast Cancer Regulation by Stathmin1	0.58	Paxillin Interactions	0.53
NFAT in Immune Response	0.58

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

TGF-Beta Pathway

	TGF-Beta Pathway	1.00			JAK-STAT Pathway	0.57
	MAPK Family Pathway	0.60			JNK Pathway	0.50

Nanog in Mammalian ESC Pluripotency

	Nanog in Mammalian ESC Pluripotency	1.00			14-3-3 Induced Intracellular Signaling	0.59
	GSK3 Signaling	0.61			eNOS Signaling	0.48

5/54 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NUDT6 (see all 54)

	Nuclear Receptor Activation by Vitamin-A
	Paxillin Interactions
	Telomerase Components in Cell Signaling
	Mitochondrial Apoptosis
	Molecular Mechanisms of Cancer

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NUDT6

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

5/27 Interacting proteins for NUDT6 (P53370³ ENSP00000306070⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 27)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ARHGAP1	Q07960³	I2D: score=3
BUD13	Q9BRD0³	I2D: score=3
CAD	P27708³	I2D: score=3
COG8	Q96MW5³	I2D: score=3
COPS3	Q9UNS2³	I2D: score=3

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008150	biological_process	ND	--

NUDT6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

NUDT6 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NUDT6
10/45 Novoseek chemical compound relationships for NUDT6 gene (see all 45) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
saporin	35.3	5	8630880 (1)
suramin	30.8	9	15840333 (6), 10398280 (1), 7678932 (1), 1984091 (1)
5-methylthioadenosine	29.3	3	8395923 (2)
17beta-hydroxysteroid	28.6	1	1338722 (1)
matrigel	26.9	4	10676661 (1), 11027671 (1), 16323075 (1), 18468232 (1)
famotidine	13.6	4	8774986 (2), 7594320 (2)
lansoprazole	11	6	8774986 (3), 7594320 (3)
ribonucleic acid	5.39	3	7815139 (1), 8559302 (1)
iron	4.43	2	8478396 (1), 7762443 (1)
dbc-amp	3.72	2	8395923 (1)

Search CenterWatch for drugs/clinical trials and news about NUDT6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NUDT6 gene (2 alternative transcripts):

NM_007083.4 NM_198041.2

Unigene Cluster for NUDT6:

Nudix (nucleoside diphosphate linked moiety X)-type motif 6

Hs.558459 [show with all ESTs]

Unigene Representative Sequence: BI560302

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000512116 ENST00000304430(uc003iew.3) ENST00000339154(uc003iex.3)

ENST00000503370 ENST00000510735 ENST00000502270 ENST00000513517

miRNA Products:		OriGene 3'-UTR Clone (see all 2): NUDT6 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NUDT6
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NUDT6
		SwitchGear 3'UTR luciferase reporter plasmid: NUDT6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NUDT6 (see all 7) OriGene shRNA RFP: NUDT6 OriGene siRNA: NUDT6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUDT6

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT6 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT6 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): NUDT6 (NM_007083)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUDT6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUDT6

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUDT6 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat NUDT6
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUDT6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUDT6

Additional cDNA sequence:

AF019632.2 AF019633.2 AK291871.1 AK294450.1 BC009842.2 L31408.1

6 DOTS entries:

DT.100712482 DT.75103181 DT.100021932 DT.416573 DT.121251235 DT.75181099

24/76 AceView cDNA sequences (see all 76):

AI479705 AI420564 BG214454 NM_198041 AI492978 BG197240 BG190638 NM_007083

AI401057 BM970451 BU619706 BG197239 AA226913 AI417721 BG200726 BQ434362

AA953379 BG212846 BF739878 AA628770 AI797323 AA284286 CA392430 BX097224

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NUDT6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACATTTTAA

About this image
See NUDT6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NUDT6

SOURCE GeneReport for Unigene cluster: Hs.558459

UniProtKB/Swiss-Prot: NUDT6_HUMAN, P53370

Tissue specificity: Detected in liver, kidney and esophagus (at protein level). Ubiquitous

SABiosciences Expression via Pathway-Focused PCR Array including NUDT6:

Mesenchymal Stem Cell in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUDT6 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat NUDT6
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUDT6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUDT6

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT6

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUDT6 gene from 8/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Nudt6^{1 , 5}	nudix (nucleoside diphosphate linked moiety X)-type more^{1, 5}	77.01(n)¹ 75.91(a)¹		3 (18.46 cM)⁵ 229228¹ NM_153561.2¹ NP_705789.1¹ 37404910⁵
chicken (Gallus gallus)	Aves	NUDT6¹	nudix (nucleoside diphosphate linked moiety X)-type more	71.35(n) 76.6(a)		422666 XM_003641202.1 XP_003641250.1
lizard (Anolis carolinensis)	Reptilia	NUDT6⁶	--	62(a)	1 ↔ 1	5(138549613-138567147)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.20390²	Transcribed sequence with weak similarity to protein more	73.98(n)		BX708145.1
zebrafish (Danio rerio)	Actinopterygii	nudt6¹	nudix (nucleoside diphosphate linked moiety X)-type more	61.3(n) 63.22(a)		100037370 NM_001089522.1 NP_001082991.1
fruit fly (Drosophila melanogaster)	Insecta	CG8128³	--	38(a)		--
thale cress (Arabidopsis thaliana)	eudicotyledons	NUDT2¹	nudix hydrolase 2	49.39(n) 38.74(a)		834816 NM_124139.3 NP_568687.1
rice (Oryza sativa)	Liliopsida	Os06g0634300¹	hypothetical protein	51.61(n) 40.1(a)		4341595 NM_001064671.1 NP_001058136.1

ENSEMBL Gene Tree for NUDT6 (if available)
TreeFam Gene Tree for NUDT6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

Human Gene Mutation Database (HGMD): NUDT6

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NUDT6

DNA2.0 Custom Variant and Variant Library Synthesis for NUDT6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NUDT6 for disorders           About GeneDecksing

OMIM gene information: 606261    OMIM disorders: --

20/75 diseases for NUDT6 (see all 75):    About MalaCards

multiple endocrine neoplasia amyotrophic lateral sclerosis gingival overgrowth lichen planus

oral lichen planus proliferative diabetic retinopathy lateral sclerosis proliferative vitreoretinopathy

moyamoya disease vitreoretinopathy pituitary adenoma diabetic retinopathy

myocardial infarction ischemic heart disease malignant glioma acute myocardial infarction

retinal degeneration benign tumors exfoliation syndrome pituitary tumor

10/57 Novoseek disease relationships for NUDT6 gene (see all 57) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
skin ulcer	36.5	1	19638336 (1)
scars hypertrophic	36.2	3	16199295 (1), 17971006 (1), 8860952 (1)
vitreoretinopathy proliferative	33.9	2	12579721 (1)
glioma	29.2	22	8559302 (4), 7984147 (2), 17306451 (2), 18799025 (2) (see all 8)
gingival overgrowth	26.9	6	9477019 (4)
retinal degeneration	23.8	1	12675490 (1)
ulcer	20.9	25	19638336 (5), 15086596 (2), 7594320 (2), 7948825 (1) (see all 8)
pituitary tumors	14.8	3	11266510 (2)
tumors	13.5	81	8146294 (5), 9625854 (4), 9149261 (3), 16278388 (3) (see all 37)
moyamoya disease	12.5	6	8893713 (3), 7694557 (1)

Human Genome Epidemiology (HuGE) Navigator: NUDT6 (10 documents)

Export disorders for NUDT6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NUDT6 gene, integrated from 9 sources (see all 345):
(articles sorted by number of sources associating them with NUDT6)

Utopia: connect your pdf to the dynamic
world of online information

Identification and characterization of an antisense RNA transcript (gfg) from the human basic fibroblast growth factor gene. (PubMed id 7984147)^{1, 2, 3, 9} Murphy P.R. and Knee R.S. (1994)
Characterization of the promoter for the human antisense fibroblast growth factor-2 gene; regulation by Ets in Jurkat T cells. (PubMed id 10022609)^{1, 2, 3} Gagnon M.L.... Klagsbrun M. (1999)
The endogenous fibroblast growth factor-2 antisense gene product regulates pituitary cell growth and hormone production. (PubMed id 11266510)^{1, 2, 9} Asa S.L.... Ezzat S. (2001)
Alternative splicing of the FGF antisense gene: differential subcellular localization in human tissues and esophageal adenocarcinoma. (PubMed id 17569023)^{1, 2, 9} Zhang S.C.... Murphy P.R. (2007)
The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells. (PubMed id 17203973)^{1, 2} Vasilescu J.... Figeys D. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Association study between keratinocyte-derived growth factor gene polymorphisms and susceptibility to vitiligo vulgaris in a Taiwanese population: potential involvement of stem cell factor. (PubMed id 19416273)^{1, 9} Lan C.C....Yu H.S. (2009)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)¹ Rajaraman P....Inskip P.D. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 11162	HGNC: 8053	AceView: NUDT6	Ensembl:ENSG00000170917	euGenes: HUgn11162
ECgene: NUDT6	H-InvDB: NUDT6

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NUDT6	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for NUDT6	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for NUDT6 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for NUDT6 gene:
Search GeneIP for patents involving NUDT6

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for NUDT6		OriGene shRNA RFP for NUDT6
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NUDT6		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUDT6
	OriGene Protein Over-expression Lysate for NUDT6		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for NUDT6		OriGene 3'-UTR Clone for NUDT6
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT6		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT6
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for NUDT6		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for NUDT6		OriGene Custom Protein Services for NUDT6
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NUDT6
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NUDT6
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUDT6
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUDT6
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUDT6
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUDT6

	GenScript Custom Purified and Recombinant Proteins Services for NUDT6		GenScript cDNA clones with any tag delivered in your preferred vector for NUDT6
	GenScript Custom Assay Services for NUDT6		GenScript Custom Superior Antibodies Services for NUDT6
	GenScript Custom overexpressing Cell Line Services for NUDT6		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in NUDT6 promoter
	Search Chromatin IP Primers for NUDT6
	RT² qPCR Primer Assay in human, mouse, rat NUDT6
	GNC Network for NUDT6
	SABiosciences PCR Arrays including human, mouse, rat NUDT6

Search Tocris compounds for NUDT6

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	NUDT6 antibodies
	NUDT6 proteins
	NUDT6 lysates

	Antibodies for NUDT6
	See all of Abcam's Antibodies, Kits and Proteins for NUDT6
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

NUDT6 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for NUDT6

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT6

	SwitchGear 3'UTR luciferase reporter plasmids for NUDT6
	SwitchGear Promoter luciferase reporter plasmids for NUDT6

ThermoFisher Antibodies for NUDT6

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUDT6

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes NUDT6 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

NUDT6 Gene

nudix (nucleoside diphosphate linked moiety X)-type motif...

Aliases
for NUDT6 gene

Summaries
for NUDT6 gene

Genomic Views
for NUDT6 gene

Proteins
for NUDT6 gene

Protein Domains /
Families
for NUDT6 gene

Function
for NUDT6 gene

Pathways & Interactions
for NUDT6 gene

Drugs & Compounds
for NUDT6 gene

Transcripts
for NUDT6 gene

Expression
for NUDT6 gene

Orthologs
for NUDT6 gene

Paralogs
for NUDT6 gene

Genomic Variants
for NUDT6 gene

Disorders / Diseases
for NUDT6 gene

Publications
for NUDT6 gene

External Searches for NUDT6 gene

Genome Databases showing NUDT6 gene

Other Databases showing NUDT6 gene

Specialized Databases showing NUDT6 gene

Intellectual Property
for NUDT6 gene

Products
for NUDT6 gene

View Random Gene

stable disease
Gastric Cancer
Leg Ulcer
Brain Tumors
Melanoma
bladder cancer
Colon Cancer
Medulloblastoma
Parkinson Disease
glaucoma
Skin Ulcer
Scars Hypertrophic
Glioma
Pituitary Tumors
PITUITARY ADENOMA
Carcinoma
INFARCT
Leukemia
Vitreoretinopathy Proliferative
Myocardial Ischemia
Alzheimers Disease
Ischemia
Breast Cancer
primary tumor
Cataract
Adenocarcinoma
Carcinoma Transitional Cell
cell damage
Amyotrophic Lateral Sclerosis
Cancer
Myopia
gastric ulcer
small cell lung cancer
Coronary Atherosclerosis
Shock
Ulcer
Scar
Adenoma
Inflammation
benign tumor
solid tumor
restenosis
immunodeficiency
Atrophy
BLADDER CARCINOMA
Multiple Endocrine Neoplasia Type 1
Retinal Degeneration
STROKE
aqueous humor
prostate cancer
Tumors
Metastasis
Gingival Overgrowth
Necrosis
Moyamoya Disease
Malignant Glioma
Choriocarcinoma

Advanced Search

Export list of displayed genes

NUDT6 Gene

nudix (nucleoside diphosphate linked moiety X)-type motif...

Aliasesfor NUDT6 gene

Summariesfor NUDT6 gene

Genomic Viewsfor NUDT6 gene

Proteinsfor NUDT6 gene

Protein Domains /Familiesfor NUDT6 gene

Functionfor NUDT6 gene

Pathways & Interactionsfor NUDT6 gene

Drugs & Compoundsfor NUDT6 gene

Transcriptsfor NUDT6 gene

Expression for NUDT6 gene

Orthologsfor NUDT6 gene

Paralogsfor NUDT6 gene

Genomic Variantsfor NUDT6 gene

Disorders / Diseasesfor NUDT6 gene

Publicationsfor NUDT6 gene

External Searches for NUDT6 gene

Genome Databases showing NUDT6 gene

Other Databases showing NUDT6 gene

Specialized Databases showing NUDT6 gene

Intellectual Propertyfor NUDT6 gene

Productsfor NUDT6 gene

View Random Gene

Aliases
for NUDT6 gene

Summaries
for NUDT6 gene

Genomic Views
for NUDT6 gene

Proteins
for NUDT6 gene

Protein Domains /
Families
for NUDT6 gene

Function
for NUDT6 gene

Pathways & Interactions
for NUDT6 gene

Drugs & Compounds
for NUDT6 gene

Transcripts
for NUDT6 gene

Expression
for NUDT6 gene

Orthologs
for NUDT6 gene

Paralogs
for NUDT6 gene

Genomic Variants
for NUDT6 gene

Disorders / Diseases
for NUDT6 gene

Publications
for NUDT6 gene

Intellectual Property
for NUDT6 gene

Products
for NUDT6 gene