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Aliases for NUDT6 Gene

Aliases for NUDT6 Gene

  • Nudix Hydrolase 6 2 3 5
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 6 2 3
  • Antisense Basic Fibroblast Growth Factor 3 4
  • FGF2AS 3 4
  • Nudix Motif 6 4
  • Protein GFG 4
  • EC 3.6.1.- 4
  • ASFGF2 3
  • FGF-AS 3
  • GFG-1 3
  • GFG1 3

External Ids for NUDT6 Gene

Previous GeneCards Identifiers for NUDT6 Gene

  • GC04M124726
  • GC04M124093
  • GC04M124207
  • GC04M124272
  • GC04M124171
  • GC04M123814
  • GC04M119540

Summaries for NUDT6 Gene

Entrez Gene Summary for NUDT6 Gene

  • This gene overlaps and lies on the opposite strand from FGF2 gene, and is thought to be the FGF2 antisense gene. The two genes are independently transcribed, and their expression shows an inverse relationship, suggesting that this antisense transcript may regulate FGF2 expression. This gene has also been shown to have hormone-regulatory and antiproliferative actions in the pituitary that are independent of FGF2 expression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for NUDT6 Gene

NUDT6 (Nudix Hydrolase 6) is a Protein Coding gene. Diseases associated with NUDT6 include Pulmonary Capillary Hemangiomatosis and Gingival Overgrowth. Among its related pathways are p70S6K Signaling and ERK Signaling. GO annotations related to this gene include hydrolase activity and growth factor activity.

UniProtKB/Swiss-Prot for NUDT6 Gene

  • May contribute to the regulation of cell proliferation.

Gene Wiki entry for NUDT6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT6 Gene

Genomics for NUDT6 Gene

Regulatory Elements for NUDT6 Gene

Enhancers for NUDT6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NUDT6 on UCSC Golden Path with GeneCards custom track

Promoters for NUDT6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NUDT6 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the NUDT6 gene promoter:

Genomic Location for NUDT6 Gene

Chromosome:
4
Start:
122,888,697 bp from pter
End:
122,923,004 bp from pter
Size:
34,308 bases
Orientation:
Minus strand

Genomic View for NUDT6 Gene

Genes around NUDT6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDT6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDT6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT6 Gene

Proteins for NUDT6 Gene

  • Protein details for NUDT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53370-NUDT6_HUMAN
    Recommended name:
    Nucleoside diphosphate-linked moiety X motif 6
    Protein Accession:
    P53370
    Secondary Accessions:
    • A8K756
    • O95097
    • Q9UQD9

    Protein attributes for NUDT6 Gene

    Size:
    316 amino acids
    Molecular mass:
    35679 Da
    Quaternary structure:
    • Monomer and homodimer.
    Miscellaneous:
    • This protein is coded from a FGF2 (BFGF) gene antisense transcript.

    Three dimensional structures from OCA and Proteopedia for NUDT6 Gene

    Alternative splice isoforms for NUDT6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUDT6 Gene

Proteomics data for NUDT6 Gene at MOPED

Post-translational modifications for NUDT6 Gene

  • Ubiquitination at Lys 76
  • Modification sites at PhosphoSitePlus

Other Protein References for NUDT6 Gene

No data available for DME Specific Peptides for NUDT6 Gene

Domains & Families for NUDT6 Gene

Gene Families for NUDT6 Gene

Suggested Antigen Peptide Sequences for NUDT6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P53370

UniProtKB/Swiss-Prot:

NUDT6_HUMAN :
  • Contains 1 nudix hydrolase domain.
  • Belongs to the Nudix hydrolase family.
Domain:
  • Contains 1 nudix hydrolase domain.
Family:
  • Belongs to the Nudix hydrolase family.
genes like me logo Genes that share domains with NUDT6: view

Function for NUDT6 Gene

Molecular function for NUDT6 Gene

GENATLAS Biochemistry:
nudix (nucleoside diphosphate linked moiety X)-type motif 6,hydrolase,antisense transcript of FGF2,coexpressed with FGF2 in many tissues,and potentially regulator of FGF2 expression,putative mouse cleaning gene whose functions is to cleanse the cell of potentially deleterious endogenous metabolites and to modulate the accumulation of intermediates in biochemical pathways
UniProtKB/Swiss-Prot Function:
May contribute to the regulation of cell proliferation.

Enzyme Numbers (IUBMB) for NUDT6 Gene

genes like me logo Genes that share phenotypes with NUDT6: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NUDT6 Gene

Localization for NUDT6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDT6 Gene

Cytoplasm. Nucleus. Mitochondrion. Note=Subcellular location may vary between isoforms.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUDT6 Gene COMPARTMENTS Subcellular localization image for NUDT6 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytoskeleton 3

Gene Ontology (GO) - Cellular Components for NUDT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with NUDT6: view

Pathways & Interactions for NUDT6 Gene

genes like me logo Genes that share pathways with NUDT6: view

Interacting Proteins for NUDT6 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000306070%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000306070 P53370-NUDT6_HUMAN for NUDT6 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for NUDT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with NUDT6: view

No data available for SIGNOR curated interactions for NUDT6 Gene

Drugs & Compounds for NUDT6 Gene

(28) Drugs for NUDT6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(17) Additional Compounds for NUDT6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NUDT6: view

Transcripts for NUDT6 Gene

Unigene Clusters for NUDT6 Gene

Nudix (nucleoside diphosphate linked moiety X)-type motif 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT6 Gene

No ASD Table

Relevant External Links for NUDT6 Gene

GeneLoc Exon Structure for
NUDT6
ECgene alternative splicing isoforms for
NUDT6

Expression for NUDT6 Gene

mRNA expression in normal human tissues for NUDT6 Gene

Protein differential expression in normal tissues from HIPED for NUDT6 Gene

This gene is overexpressed in Gallbladder (27.6), Liver (10.7), Kidney (10.2), and Heart (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for NUDT6 Gene



SOURCE GeneReport for Unigene cluster for NUDT6 Gene Hs.558459

mRNA Expression by UniProt/SwissProt for NUDT6 Gene

P53370-NUDT6_HUMAN
Tissue specificity: Detected in liver, kidney and esophagus (at protein level). Ubiquitous.
genes like me logo Genes that share expression patterns with NUDT6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for NUDT6 Gene

Orthologs for NUDT6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUDT6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NUDT6 35
  • 90.2 (n)
  • 89.08 (a)
NUDT6 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUDT6 35
  • 86.58 (n)
  • 83.71 (a)
NUDT6 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nudt6 35
  • 77.01 (n)
  • 75.91 (a)
Nudt6 16
Nudt6 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NUDT6 35
  • 99.37 (n)
  • 99.05 (a)
NUDT6 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nudt6 35
  • 79.83 (n)
  • 81.88 (a)
oppossum
(Monodelphis domestica)
Mammalia NUDT6 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUDT6 35
  • 75.93 (n)
  • 81.25 (a)
NUDT6 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUDT6 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nudt6 35
  • 69.01 (n)
  • 68.89 (a)
Str.20390 35
zebrafish
(Danio rerio)
Actinopterygii nudt6 35
  • 60.73 (n)
  • 61.82 (a)
nudt6 36
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8128 37
  • 38 (a)
CG8128 35
  • 45.26 (n)
  • 39.71 (a)
CG8128 36
  • 29 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012857 35
  • 43.21 (n)
  • 32.92 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons NUDT8 35
  • 48.91 (n)
  • 40.7 (a)
rice
(Oryza sativa)
Liliopsida Os04g0547900 35
  • 48.86 (n)
  • 41.67 (a)
Species with no ortholog for NUDT6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUDT6 Gene

ENSEMBL:
Gene Tree for NUDT6 (if available)
TreeFam:
Gene Tree for NUDT6 (if available)

Paralogs for NUDT6 Gene

No data available for Paralogs for NUDT6 Gene

Variants for NUDT6 Gene

Sequence variations from dbSNP and Humsavar for NUDT6 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_021909 -
rs12648093 - 122,917,603(+) AAAGC(A/G)GAAGC reference, missense, utr-variant-5-prime
rs877284 -- 122,917,913(+) CCTTC(A/G)GAATA intron-variant
rs877808 -- 122,918,872(-) gtaca(C/G)ttaag intron-variant
rs898090 -- 122,907,830(-) CCCCA(A/C)GATAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUDT6 Gene

Variant ID Type Subtype PubMed ID
nsv879867 CNV Gain 21882294
esv2657447 CNV Deletion 23128226

Variation tolerance for NUDT6 Gene

Residual Variation Intolerance Score: 71.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.58; 82.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUDT6 Gene

Human Gene Mutation Database (HGMD)
NUDT6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT6 Gene

Disorders for NUDT6 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NUDT6 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
pulmonary capillary hemangiomatosis
gingival overgrowth
  • gingival enlargement
bone fracture
- elite association - COSMIC cancer census association via MalaCards
Search NUDT6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NUDT6

Genetic Association Database (GAD)
NUDT6
Human Genome Epidemiology (HuGE) Navigator
NUDT6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUDT6
genes like me logo Genes that share disorders with NUDT6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUDT6 Gene

Publications for NUDT6 Gene

  1. Identification and characterization of an antisense RNA transcript (gfg) from the human basic fibroblast growth factor gene. (PMID: 7984147) Murphy P.R. … Knee R.S. (Mol. Endocrinol. 1994) 2 3 4 23 67
  2. The endogenous fibroblast growth factor-2 antisense gene product regulates pituitary cell growth and hormone production. (PMID: 11266510) Asa S.L. … Ezzat S. (Mol. Endocrinol. 2001) 3 23
  3. Characterization of the promoter for the human antisense fibroblast growth factor-2 gene; regulation by Ets in Jurkat T cells. (PMID: 10022609) Gagnon M.L. … Klagsbrun M. (J. Cell. Biochem. 1999) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Genome-wide association study identifies two novel genomic regions in irritable bowel syndrome. (PMID: 24797007) Holliday E.G. … Talley N.J. (Am. J. Gastroenterol. 2014) 3

Products for NUDT6 Gene

Sources for NUDT6 Gene

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