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NUDT6 Gene

protein-coding   GIFtS: 57
GCID: GC04M123814

Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif...

  See NUDT6-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 61 2     GFG12
Antisense Basic Fibroblast Growth Factor2 3     Nucleoside Diphosphate-Linked Moiety X Motif 62
FGF2AS2 3     EC 3.6.1.-3
ASFGF22     Nudix Motif 63
FGF-AS2     Protein GFG3
GFG-12     

External Ids:    HGNC: 80531   Entrez Gene: 111622   Ensembl: ENSG000001709177   OMIM: 6062615   UniProtKB: P533703   

Export aliases for NUDT6 gene to outside databases

Previous GC identifers: GC04M124726 GC04M124093 GC04M124207 GC04M124272 GC04M124171 GC04M119540


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NUDT6 Gene:
This gene overlaps and lies on the opposite strand from FGF2 gene, and is thought to be the FGF2 antisense gene.
The two genes are independently transcribed, and their expression shows an inverse relationship, suggesting that
this antisense transcript may regulate FGF2 expression. This gene has also been shown to have hormone-regulatory
and antiproliferative actions in the pituitary that are independent of FGF2 expression. Alternatively spliced
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for NUDT6 Gene:
NUDT6 (nudix (nucleoside diphosphate linked moiety X)-type motif 6) is a protein-coding gene. Diseases associated with NUDT6 include gingival overgrowth, and exfoliation syndrome. GO annotations related to this gene include hydrolase activity and growth factor activity.

UniProtKB/Swiss-Prot: NUDT6_HUMAN, P53370
Function: May contribute to the regulation of cell proliferation

Gene Wiki entry for NUDT6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the NUDT6 gene promoter:
         AP-1   STAT3   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNUDT6 promoter sequence
   Search Chromatin IP Primers for NUDT6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NUDT6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q26   Ensembl cytogenetic band:  4q28.1   HGNC cytogenetic band: 4q26

NUDT6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUDT6 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M123814:  view genomic region     (about GC identifiers)

Start:
123,809,852 bp from pter      End:
123,844,123 bp from pter
Size:
34,272 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NUDT6_HUMAN, P53370 (See protein sequence)
Recommended Name: Nucleoside diphosphate-linked moiety X motif 6  
Size: 316 amino acids; 35679 Da
Subunit: Monomer and homodimer (Probable)
Miscellaneous: This protein is coded from a FGF2 (BFGF) gene antisense transcript
Caution: The rat protein was reported to play a role in DNA repair (PubMed:9406864), based on its ability to
complement E.coli deficient in the DNA repair enzyme mutT that hydrolyzes oxidized guanine nucleotides.
PubMed:17569023 found no such activity, neither for the human nor the rat protein
2 PDB 3D structures from and Proteopedia for NUDT6:
3FXT (3D)        3H95 (3D)    
Secondary accessions: A8K756 O95097 Q9UQD9
Alternative splicing: 2 isoforms:  P53370-1   P53370-2   

Explore the universe of human proteins at neXtProt for NUDT6: NX_P53370

Explore proteomics data for NUDT6 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys76
  • Modification sites at PhosphoSitePlus

  • See NUDT6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_009014.2  NP_932158.1  

    ENSEMBL proteins: 
     ENSP00000420843   ENSP00000306070   ENSP00000344011   ENSP00000422698   ENSP00000423745  
     ENSP00000424117  

    NUDT6 Human Recombinant Protein Products:

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    Novus Biologicals NUDT6 Protein
    Novus Biologicals NUDT6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for NUDT6

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NUDT: Nudix motif containing

    4 InterPro protein domains:
     IPR015797 NUDIX_hydrolase_dom-like
     IPR020084 NUDIX_hydrolase_CS
     IPR003293 Nudix_hydrolase6-like
     IPR000086 NUDIX_hydrolase_dom

    Graphical View of Domain Structure for InterPro Entry P53370

    ProtoNet protein and cluster: P53370

    2 Blocks protein domains:
    IPB000086 NUDIX hydrolase
    IPB003293 Anti-sense to fibroblast growth factor protein GFG signature


    UniProtKB/Swiss-Prot: NUDT6_HUMAN, P53370
    Similarity: Belongs to the Nudix hydrolase family
    Similarity: Contains 1 nudix hydrolase domain


    Find genes that share domains with NUDT6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NUDT6_HUMAN, P53370
    Function: May contribute to the regulation of cell proliferation

         Genatlas biochemistry entry for NUDT6:
    nudix (nucleoside diphosphate linked moiety X)-type motif 6,hydrolase,antisense transcript of FGF2,coexpressed
    with FGF2 in many tissues,and potentially regulator of FGF2 expression,putative mouse cleaning gene whose
    functions is to cleanse the cell of potentially deleterious endogenous metabolites and to modulate the
    accumulation of intermediates in biochemical pathways

         Enzyme Number (IUBMB): EC 3.6.1.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008083growth factor activity TAS7984147
    GO:0016787hydrolase activity IEA--
         
    Find genes that share ontologies with NUDT6           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NUDT6:
     Decreased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NUDT6
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    miRNA
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    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat NUDT6

    Gene Editing
    Products:
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NUDT6 (NM_007083)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUDT6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUDT6

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    In Situ Assay
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NUDT6_HUMAN, P53370: Cytoplasm. Nucleus. Mitochondrion. Note=Subcellular location may vary between isoforms
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus5
    cytoskeleton1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005634nucleus IEA--
    GO:0005739mitochondrion IEA--

    Find genes that share ontologies with NUDT6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NUDT6 About   (see all 12)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    2GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    3ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    4Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    5TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JAK-STAT Pathway0.57
    MAPK Family Pathway0.60
    JNK Pathway0.51

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NUDT6 (see all 54)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer


        Pathway & Disease-focused RT2 Profiler PCR Array including NUDT6: 
              Mesenchymal Stem Cell in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NUDT6

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    Selected Interacting proteins for NUDT6 (P533703 ENSP000003060704) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARHGAP1Q079603I2D: score=3 
    BUD13Q9BRD03I2D: score=3 
    CADP277083I2D: score=3 
    COG8Q96MW53I2D: score=3 
    COPS3Q9UNS23I2D: score=3 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    Find genes that share ontologies with NUDT6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NUDT6

    Selected Novoseek inferred chemical compound relationships for NUDT6 gene (see all 45)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    saporin 35.3 5 8630880 (1)
    suramin 30.8 9 15840333 (6), 10398280 (1), 7678932 (1), 1984091 (1)
    5-methylthioadenosine 29.3 3 8395923 (2)
    17beta-hydroxysteroid 28.6 1 1338722 (1)
    matrigel 26.9 4 10676661 (1), 11027671 (1), 16323075 (1), 18468232 (1)
    famotidine 13.6 4 8774986 (2), 7594320 (2)
    lansoprazole 11 6 8774986 (3), 7594320 (3)
    ribonucleic acid 5.39 3 7815139 (1), 8559302 (1)
    iron 4.43 2 8478396 (1), 7762443 (1)
    dbc-amp 3.72 2 8395923 (1)



    Find genes that share compounds with NUDT6           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NUDT6 gene (2 alternative transcripts): 
    NM_007083.4  NM_198041.2  

    Unigene Cluster for NUDT6:

    Nudix (nucleoside diphosphate linked moiety X)-type motif 6
    Hs.558459  [show with all ESTs]
    Unigene Representative Sequence: BI560302
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000608639 ENST00000512116 ENST00000304430(uc003iew.3) ENST00000339154(uc003iex.3)
    ENST00000503370 ENST00000510735 ENST00000502270 ENST00000513517
    miRNA
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    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat NUDT6
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NUDT6 (NM_007083)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat NUDT6
      QuantiFast Probe-based Assays in human, mouse, rat NUDT6

    Additional mRNA sequence: 

    AF019632.2 AF019633.2 AK291871.1 AK294450.1 BC009842.2 

    5 DOTS entries:

    DT.100712482  DT.75103181  DT.100021932  DT.416573  DT.75181099 

    Selected AceView cDNA sequences (see all 76):

    AI479705 NM_007083 BG200726 BG190638 AI492978 BG197240 BQ434362 AI401057 
    BG214454 AI420564 NM_198041 AA953379 BG197239 AA226913 BM970451 BU619706 
    AI417721 CB148889 AI948761 BF739878 AA281223 AI074587 BQ716561 CB128685 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NUDT6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACATTTTAA
    NUDT6 Expression
    About this image

    NUDT6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NUDT6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.558459

    UniProtKB/Swiss-Prot: NUDT6_HUMAN, P53370
    Tissue specificity: Detected in liver, kidney and esophagus (at protein level). Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Array including NUDT6: 
              Mesenchymal Stem Cell in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat NUDT6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NUDT6 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nudt61 , 5 nudix (nucleoside diphosphate linked moiety X)-type more1, 5 77.01(n)1
    75.91(a)1
      3 (18.46 cM)5
    2292281  NM_153561.21  NP_705789.11 
     374049105 
    chicken
    (Gallus gallus)
    Aves NUDT61 nudix (nucleoside diphosphate linked moiety X)-type more 75.93(n)
    81.25(a)
      422666  XM_003641202.2  XP_003641250.2 
    lizard
    (Anolis carolinensis)
    Reptilia NUDT66
    nudix (nucleoside diphosphate linked moiety X)-typ...
    64(a)
    1 ↔ 1
    5(138549727-138571846)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.203902 Transcribed sequence with weak similarity to protein more 73.98(n)    BX708145.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nudt61 nudix (nucleoside diphosphate linked moiety X)-type more 60.73(n)
    61.82(a)
      100037370  NM_001089522.1  NP_001082991.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG81281 , 3 CG81281 38(a)3
    45.26(n)1
    39.71(a)1
      325041  NM_132825.31  NP_573053.21 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons NUDT81 NUDT8 48.91(n)
    40.7(a)
      834771  NM_124095.3  NP_568680.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g05479001 Os04g0547900 48.86(n)
    41.67(a)
      4336574  NM_001060011.1  NP_001053476.1 


    ENSEMBL Gene Tree for NUDT6 (if available)
    TreeFam Gene Tree for NUDT6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NUDT6 (see all 734)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs723624521,2
    C--119549867(+) GTATA-/ATTG  
            
    TTGGG
    2 -- int10--------
    rs2000476551,2
    C--119556673(+) CCAGC-/TTTTTT 2 -- int10--------
    rs1420268401,2
    C--119558190(+) CTTCT-/GAAACC 2 -- int10--------
    rs1112500291,2
    C,F--123599184(+) TTTAAT/CGGCCA 2 -- ds50012Minor allele frequency- C:0.00NS EU 1863
    rs1863127881,2
    --123599272(+) ATAGCC/TCAGTT 2 -- ds50010--------
    rs38041561,2
    C,F,H--123599281(+) TTTGGA/GTAATT 2 -- ds50018Minor allele frequency- G:0.00EA NS NA 1954
    rs456277361,2
    C,F--123599345(+) GAAAAA/CTAACA 2 -- ds50013Minor allele frequency- C:0.03NS NA 838
    rs2001670491,2
    --123599573(+) CATTCA/GTTAGT 2 -- ut310--------
    rs1481233531,2
    C--123599750(+) AGCAGC/TAGCCT 4 L syn10--------
    rs456066401,2
    C,F--123599790(+) TTTCAG/ATCTTC 4 /T /I mis12Minor allele frequency- A:0.00NA EU 5873

    HapMap Linkage Disequilibrium report for NUDT6 (123809852 - 123844123 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NUDT6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2657447CNV Deletion23128226
    nsv879867CNV Gain21882294

    Human Gene Mutation Database (HGMD): NUDT6
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NUDT6
    DNA2.0 Custom Variant and Variant Library Synthesis for NUDT6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606261    OMIM disorders: --

    10 diseases for NUDT6:    
    About MalaCards
    gingival overgrowth    exfoliation syndrome    gastric ulcer    bone fracture
    moyamoya disease    head injury    diabetic neuropathy    bladder carcinoma
    malignant glioma    amyotrophic lateral sclerosis


    Find genes that share disorders with NUDT6           About GenesLikeMe

    Selected Novoseek inferred disease relationships for NUDT6 gene (see all 57)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    skin ulcer 36.5 1 19638336 (1)
    scars hypertrophic 36.2 3 16199295 (1), 17971006 (1), 8860952 (1)
    vitreoretinopathy proliferative 33.9 2 12579721 (1)
    glioma 29.2 22 8559302 (4), 7984147 (2), 17306451 (2), 18799025 (2) (see all 8)
    gingival overgrowth 26.9 6 9477019 (4)
    retinal degeneration 23.8 1 12675490 (1)
    ulcer 20.9 25 19638336 (5), 15086596 (2), 7594320 (2), 7948825 (1) (see all 8)
    pituitary tumors 14.8 3 11266510 (2)
    tumors 13.5 81 8146294 (5), 9625854 (4), 9149261 (3), 16278388 (3) (see all 37)
    moyamoya disease 12.5 6 8893713 (3), 7694557 (1)

    Genetic Association Database (GAD): NUDT6
    Human Genome Epidemiology (HuGE) Navigator: NUDT6 (10 documents)

    Export disorders for NUDT6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NUDT6 gene, integrated from 10 sources (see all 346):
    (articles sorted by number of sources associating them with NUDT6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of an antisense RNA transcript (gfg) from the human basic fibroblast growth factor gene. (PubMed id 7984147)1, 2, 3, 9 Murphy P.R. and Knee R.S. (Mol. Endocrinol. 1994)
    2. Characterization of the promoter for the human antisense fibroblast growth factor-2 gene; regulation by Ets in Jurkat T cells. (PubMed id 10022609)1, 2, 3 Gagnon M.L.... Klagsbrun M. (J. Cell. Biochem. 1999)
    3. The endogenous fibroblast growth factor-2 antisense gene product regulates pituitary cell growth and hormone production. (PubMed id 11266510)1, 2, 9 Asa S.L.... Ezzat S. (Mol. Endocrinol. 2001)
    4. Alternative splicing of the FGF antisense gene: differential subcellular localization in human tissues and esophageal adenocarcinoma. (PubMed id 17569023)1, 2, 9 Zhang S.C.... Murphy P.R. (J. Mol. Med. 2007)
    5. Association study between keratinocyte-derived growth factor gene polymorphisms and susceptibility to vitiligo vulgaris in a Taiwanese population: potential involvement of stem cell factor. (PubMed id 19416273)1, 4, 9 Lan C.C....Yu H.S. (Br. J. Dermatol. 2009)
    6. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    7. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    8. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence. (PubMed id 19054571)1, 4 GregA^rio S.P....Dias-Neto E. (Psychiatry Res 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11162 HGNC: 8053 AceView: NUDT6 Ensembl:ENSG00000170917 euGenes: HUgn11162
    ECgene: NUDT6 H-InvDB: NUDT6

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NUDT6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NUDT6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NUDT6 gene:
    Search GeneIP for patents involving NUDT6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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