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NUDT5 Gene

protein-coding   GIFtS: 59
GCID: GC10M012207

Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif...

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 51 2     hYSAH12
8-Oxo-DGDP Phosphatase2 3     EC 3.6.1.133
YSA1H2 3     EC 3.6.1.583
YSA12     Nucleoside Diphosphate-Linked Moiety X Motif 53
YSAH12     Nudix Motif 53
ADP-Sugar Pyrophosphatase2     

External Ids:    HGNC: 80521   Entrez Gene: 111642   Ensembl: ENSG000001656097   OMIM: 6092305   UniProtKB: Q9UKK93   

Export aliases for NUDT5 gene to outside databases

Previous GC identifers: GC10M012153 GC10M012357 GC10M012213 GC10M012249 GC10M012126


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NUDT5 Gene:
This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme
catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing
8-oxo-dADP and 8-oxo-dGDP. Protein-bound ADP ribose can be hazardous to the cell because it can modify some amino
acid residues, resulting in the inhibition of ATP-activated potassium channels. 8-oxoGua is an oxidized form of
guanine that can potentially alter genetic information by pairing with adenine and cytosine in RNA. Presence of
8-oxoGua in RNA results in formation of abnormal proteins due to translational errors. (provided by RefSeq, Aug
2013)

GeneCards Summary for NUDT5 Gene:
NUDT5 (nudix (nucleoside diphosphate linked moiety X)-type motif 5) is a protein-coding gene. Diseases associated with NUDT5 include cerebritis. GO annotations related to this gene include magnesium ion binding and m7G(5')pppN diphosphatase activity.

UniProtKB/Swiss-Prot: NUDT5_HUMAN, Q9UKK9
Function: Hydrolyzes with similar activities ADP-ribose ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can
also hydrolyze other nucleotide sugars with low activity. Does not play a role in U8 snoRNA decapping activity.
Binds U8 snoRNA

Gene Wiki entry for NUDT5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_008705.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the NUDT5 gene promoter:
         STAT1   p53   NCX/Ncx   SREBP-1c   STAT1beta   Ik-3   LCR-F1   STAT1alpha   SREBP-1b   SREBP-1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNUDT5 promoter sequence
   Search Chromatin IP Primers for NUDT5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NUDT5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p14   Ensembl cytogenetic band:  10p13   HGNC cytogenetic band: 10p14

NUDT5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUDT5 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M012207:  view genomic region     (about GC identifiers)

Start:
12,207,324 bp from pter      End:
12,238,143 bp from pter
Size:
30,820 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NUDT5_HUMAN, Q9UKK9 (See protein sequence)
Recommended Name: ADP-sugar pyrophosphatase  
Size: 219 amino acids; 24328 Da
Cofactor: Binds 3 magnesium ions per subunit
Subunit: Homodimer
Selected PDB 3D structures from and Proteopedia for NUDT5 (see all 7):
2DSB (3D)        2DSC (3D)        2DSD (3D)        3AC9 (3D)        3ACA (3D)        3BM4 (3D)    
Secondary accessions: A8K516 Q6IAG0 Q9UH49

Explore the universe of human proteins at neXtProt for NUDT5: NX_Q9UKK9

Explore proteomics data for NUDT5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys27, Lys175, Lys210, Lys218
  • Modification sites at PhosphoSitePlus

  • See NUDT5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_054861.2  
    ENSEMBL proteins: 
     ENSP00000419628   ENSP00000368219   ENSP00000436844   ENSP00000368222   ENSP00000368209  
     ENSP00000407856   ENSP00000445116  
    Reactome Protein details: Q9UKK9

    NUDT5 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NUDT: Nudix motif containing

    4 InterPro protein domains:
     IPR015797 NUDIX_hydrolase_dom-like
     IPR020476 Nudix_hydrolase
     IPR020084 NUDIX_hydrolase_CS
     IPR000086 NUDIX_hydrolase_dom

    Graphical View of Domain Structure for InterPro Entry Q9UKK9

    ProtoNet protein and cluster: Q9UKK9

    1 Blocks protein domain: IPB000086 NUDIX hydrolase

    UniProtKB/Swiss-Prot: NUDT5_HUMAN, Q9UKK9
    Similarity: Belongs to the Nudix hydrolase family
    Similarity: Contains 1 nudix hydrolase domain


    NUDT5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NUDT5_HUMAN, Q9UKK9
    Function: Hydrolyzes with similar activities ADP-ribose ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can
    also hydrolyze other nucleotide sugars with low activity. Does not play a role in U8 snoRNA decapping activity.
    Binds U8 snoRNA
    Catalytic activity: ADP-D-ribose + H(2)O = AMP + D-ribose 5-phosphate
    Catalytic activity: ADP-sugar + H(2)O = AMP + alpha-D-aldose 5-phosphate
    Catalytic activity: 8-oxo-dGDP + H(2)O = 8-oxo-dGMP + phosphate

         Genatlas biochemistry entry for NUDT5:
    nudix (nucleoside diphosphate linked moiety X)-type motif 5,hydrolase,NDP- sugar hydrolase,putative mouse cleaning
    gene whose functions is to cleanse the cell of potentially deleterious endogenous metabolites and to modulate the
    accumulation of intermediates in biochemical pathways

         Enzyme Numbers (IUBMB): EC 3.6.1.131 EC 3.6.1.581

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA18462755
    GO:0016787hydrolase activity ----
    GO:0017110nucleoside-diphosphatase activity IEA--
    GO:0019144ADP-sugar diphosphatase activity IDA10567213
    GO:0030515snoRNA binding ISS--
         
    NUDT5 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Nudt5 (no phenotypes)

    NUDT5 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NUDT5
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    miRNA
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    miRTarBase miRNAs that target NUDT5:
    hsa-let-7a-5p (MIRT052516), hsa-mir-877-3p (MIRT036897), hsa-mir-34a-5p (MIRT047366)

    Block miRNA regulation of human, mouse, rat NUDT5 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate NUDT5:
    hsa-miR-520d-5p hsa-miR-524-5p
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3
    cytoskeleton1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular NAS10567213
    GO:0005829cytosol TAS--
    GO:0070062extracellular vesicular exosome IDA19056867

    NUDT5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NUDT5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Purine metabolism (REACTOME)
    Metabolism of nucleotides0.42
    Phosphate bond hydrolysis by NUDT proteins0.00
    2Purine metabolism (KEGG)
    Purine metabolism0.38
    3Metabolism
    Metabolism0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for NUDT5
        Phosphate bond hydrolysis by NUDT proteins


    1 Kegg Pathway  (Kegg details for NUDT5):
        Purine metabolism


    NUDT5 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NUDT5
    Interactions:

        Search GeneGlobe Interaction Network for NUDT5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NUDT5 (Q9UKK92, 3 ENSP000004196284) via UniProtKB, MINT, STRING, and/or I2D (see all 53)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK6Q166592, 3MINT-8261571 I2D: score=2 
    NUDT3O959892, 3MINT-8264891 I2D: score=2 
    MCM3APO603182, 3, ENSP000002916884MINT-65754 I2D: score=5 STRING: ENSP00000291688
    CDAP323203, ENSP000003642124I2D: score=2 STRING: ENSP00000364212
    ARFGAP1Q8N6T33, ENSP000003146154I2D: score=1 STRING: ENSP00000314615
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006139nucleobase-containing compound metabolic process ----
    GO:0009117nucleotide metabolic process NAS10567213
    GO:0009191ribonucleoside diphosphate catabolic process IDA18462755
    GO:0019303D-ribose catabolic process NAS10567213
    GO:0034656nucleobase-containing small molecule catabolic process TAS--

    NUDT5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for NUDT5

    6 HMDB Compounds for NUDT5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine diphosphate ribose(Rib5)ppA (see all 13)20762-30-5--
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    D-Ribose 5-phosphateD-Ribose 5-phosphate (see all 11)3615-55-2--
    D-Ribulose 5-phosphateD-Ribulose 5-phosphate (see all 5)4151-19-3--
    MagnesiumMagnesium (see all 2)7439-95-4--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    4 Novoseek inferred chemical compound relationships for NUDT5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adp-sugar 97.5 4 11287126 (3), 10567213 (1)
    adp-mannose 97.1 2 11287126 (1), 10567213 (1)
    adp glucose 80.3 1 11287126 (1)
    adpribose 72.7 9 17261271 (3), 11287126 (2), 10567213 (2)



    NUDT5 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NUDT5 gene: 
    NM_014142.2  

    Unigene Cluster for NUDT5:

    Nudix (nucleoside diphosphate linked moiety X)-type motif 5
    Hs.555956  [show with all ESTs]
    Unigene Representative Sequence: CA453885
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000491614 ENST00000378937 ENST00000378952 ENST00000476462 ENST00000378940
    ENST00000378927 ENST00000498825 ENST00000444732 ENST00000537776(uc001ilj.3)

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    Additional mRNA sequence: 

    AF155832.1 AF161464.1 AF218818.1 AK291131.1 AK314144.1 BC000025.2 CR457195.1 

    23 DOTS entries:

    DT.417545  DT.451643  DT.100673352  DT.97806094  DT.95208640  DT.86852431  DT.100673353  DT.75156053 
    DT.95208643  DT.97839587  DT.100673350  DT.100673355  DT.92453911  DT.100673354  DT.100712772  DT.100873979 
    DT.102833492  DT.121284582  DT.121284653  DT.95266021  DT.121284680  DT.92453905  DT.95373278 

    Selected AceView cDNA sequences (see all 471):

    N49750 BU956591 BE278748 CB148170 CB135047 CF126462 AA298336 BM758816 
    BE894398 AA001923 BU845134 BQ054555 BP871408 CA397725 BQ642186 BP870834 
    BE620279 CR622275 AA234971 AL556615 CA867355 BE618326 CA773276 CR611074 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NUDT5 expression in normal human tissues (normalized intensities)      NUDT5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAATGCAAA
    NUDT5 Expression
    About this image


    NUDT5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Bone (Muscoskeletal System)
             Membranous Facial Bones
     
     Kidney (Urinary System)
             Metanephros
    NUDT5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NUDT5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.555956

    UniProtKB/Swiss-Prot: NUDT5_HUMAN, Q9UKK9
    Tissue specificity: Widely expressed. Most abundant in liver

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NUDT5 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nudt51 , 5 nudix (nucleoside diphosphate linked moiety X)-type more1, 5 80.89(n)1
    82.57(a)1
      2 (3.62 cM)5
    538931  NM_016918.31  NP_058614.11 
     58450195 
    chicken
    (Gallus gallus)
    Aves LOC4263681 nudix (nucleoside diphosphate linked moiety X)-type more 72.15(n)
    70.32(a)
      426368  NM_001278107.1  NP_001265036.1 
    lizard
    (Anolis carolinensis)
    Reptilia NUDT56
    nudix (nucleoside diphosphate linked moiety X)-typ...
    70(a)
    1 ↔ 1
    GL343349.1(558070-576698)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.172842 Xenopus laevis transcribed sequence with weak similarity more 74.49(n)    48050339 
    zebrafish
    (Danio rerio)
    Actinopterygii nudt51 nudix (nucleoside diphosphate linked moiety X)-type more 64.04(n)
    59.61(a)
      415176  NM_001002086.1  NP_001002086.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ndx-21 ndx-2 46.56(n)
    36.51(a)
      189126  NM_071325.3  NP_503726.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YSA11 YSA1 49.07(n)
    44.44(a)
      852408   NP_009669.1 


    ENSEMBL Gene Tree for NUDT5 (if available)
    TreeFam Gene Tree for NUDT5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NUDT5 gene

    NUDT5 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NUDT5
    PGOHUM00000243163


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NUDT5 (see all 587)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1845688601,2
    --12212537(+) TCAAAC/TTCTGT 1 -- int10--------
    rs1414953201,2
    C--12212581(+) TGCAG-/TTTTAC 1 -- int10--------
    rs1999661441,2
    --12212671(+) GGGAC-/GAGGGGA 1 -- int10--------
    rs2009444601,2
    C--12212672(+) GGACG-/ATGGGAG 1 -- int10--------
    rs2007674171,2
    --12212753(+) AAAGAA/GATGAC 2 I syn10--------
    rs797755351,2
    C--12212806(+) CTAACA/GTCAAG 1 -- int10--------
    rs1894465801,2
    C--12212919(+) ATAAAC/TAGAAG 1 -- int10--------
    rs1412850831,2
    C--12212959(+) AACATC/TGGAAG 1 -- int10--------
    rs786662921,2
    C--12213121(+) TAGTAC/TGTATA 1 -- int10--------
    rs1482368881,2
    --12213208(+) GTACAA/GTTCAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for NUDT5 (12207324 - 12238143 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NUDT5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5820CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NUDT5
    DNA2.0 Custom Variant and Variant Library Synthesis for NUDT5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609230    OMIM disorders: --

    1 disease for NUDT5:    About MalaCards
    cerebritis


    NUDT5 for disorders           About GeneDecksing


    Export disorders for NUDT5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NUDT5 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with NUDT5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression and characterization of YSA1H, a human adenosine 5'-diphosphosugar pyrophosphatase possessing a MutT motif. (PubMed id 10567213)1, 2, 9 Gasmi L.... McLennan A.G. (Biochem. J. 1999)
    2. Molecular mechanism of ADP-ribose hydrolysis by human NUDT5 from structural and kinetic studies. (PubMed id 18462755)1, 2 Zha M.... Ding J. (J. Mol. Biol. 2008)
    3. Crystal structures of human NUDT5 reveal insights into the structural basis of the substrate specificity. (PubMed id 17052728)1, 2 Zha M.... Ding J. (J. Mol. Biol. 2006)
    4. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    7. Cloning and characterization of a new member of the Nudix hydrolases from human and mouse. (PubMed id 10722730)1, 2 Yang H.... Miller J.H. (J. Biol. Chem. 2000)
    8. The MutT motif family of nucleotide phosphohydrolases in man and human pathogens (review). (PubMed id 10373642)1, 3 McLennan A.G. (Int. J. Mol. Med. 1999)
    9. Activation of NUDT5, an ADP-ribose pyrophosphatase, by nitric oxide-mediated ADP-ribosylation. (PubMed id 17261271)1, 9 Yu H.N....Kim J.S. (Biochem. Biophys. Res. Commun. 2007)
    10. A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides. (PubMed id 12717453)1, 9 Ishibashi T....Sekiguchi M. (EMBO Rep. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11164 HGNC: 8052 AceView: NUDT5 Ensembl:ENSG00000165609 euGenes: HUgn11164
    ECgene: NUDT5 Kegg: 11164 H-InvDB: NUDT5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NUDT5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NUDT5 gene:
    Search GeneIP for patents involving NUDT5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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