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Aliases for NUDT5 Gene

Aliases for NUDT5 Gene

  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 5 2 3
  • 8-Oxo-DGDP Phosphatase 3 4
  • YSA1H 3 4
  • Nucleoside Diphosphate-Linked Moiety X Motif 5 4
  • Nudix Motif 5 4
  • EC 3.6.1.13 4
  • EC 3.6.1.58 4
  • HYSAH1 3
  • YSAH1 3
  • YSA1 3

External Ids for NUDT5 Gene

Previous GeneCards Identifiers for NUDT5 Gene

  • GC10M012153
  • GC10M012357
  • GC10M012213
  • GC10M012249
  • GC10M012126

Summaries for NUDT5 Gene

Entrez Gene Summary for NUDT5 Gene

  • This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing 8-oxo-dADP and 8-oxo-dGDP. Protein-bound ADP ribose can be hazardous to the cell because it can modify some amino acid residues, resulting in the inhibition of ATP-activated potassium channels. 8-oxoGua is an oxidized form of guanine that can potentially alter genetic information by pairing with adenine and cytosine in RNA. Presence of 8-oxoGua in RNA results in formation of abnormal proteins due to translational errors. [provided by RefSeq, Aug 2013]

GeneCards Summary for NUDT5 Gene

NUDT5 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 5) is a Protein Coding gene. Among its related pathways are Metabolism and Pyrimidine metabolism (KEGG). GO annotations related to this gene include hydrolase activity and snoRNA binding.

UniProtKB/Swiss-Prot for NUDT5 Gene

  • Hydrolyzes with similar activities ADP-ribose ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.

Gene Wiki entry for NUDT5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT5 Gene

Genomics for NUDT5 Gene

Regulatory Elements for NUDT5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NUDT5 Gene

Chromosome:
10
Start:
12,165,325 bp from pter
End:
12,196,144 bp from pter
Size:
30,820 bases
Orientation:
Minus strand

Genomic View for NUDT5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUDT5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT5 Gene

Proteins for NUDT5 Gene

  • Protein details for NUDT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKK9-NUDT5_HUMAN
    Recommended name:
    ADP-sugar pyrophosphatase
    Protein Accession:
    Q9UKK9
    Secondary Accessions:
    • A8K516
    • Q6IAG0
    • Q9UH49

    Protein attributes for NUDT5 Gene

    Size:
    219 amino acids
    Molecular mass:
    24328 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 3 Mg(2+) ions per subunit.;
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for NUDT5 Gene

neXtProt entry for NUDT5 Gene

Proteomics data for NUDT5 Gene at MOPED

Post-translational modifications for NUDT5 Gene

  • Ubiquitination at Lys 27, Lys 175, Lys 210, and Lys 218
  • Modification sites at PhosphoSitePlus

Other Protein References for NUDT5 Gene

Antibody Products

  • R&D Systems Antibodies for NUDT5 (ADP-Sugar Pyrophosphatase/NUDT5)

No data available for DME Specific Peptides for NUDT5 Gene

Domains & Families for NUDT5 Gene

Gene Families for NUDT5 Gene

Protein Domains for NUDT5 Gene

Suggested Antigen Peptide Sequences for NUDT5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UKK9

UniProtKB/Swiss-Prot:

NUDT5_HUMAN :
  • Contains 1 nudix hydrolase domain.
  • Belongs to the Nudix hydrolase family.
Domain:
  • Contains 1 nudix hydrolase domain.
Family:
  • Belongs to the Nudix hydrolase family.
genes like me logo Genes that share domains with NUDT5: view

Function for NUDT5 Gene

Molecular function for NUDT5 Gene

GENATLAS Biochemistry:
nudix (nucleoside diphosphate linked moiety X)-type motif 5,hydrolase,NDP- sugar hydrolase,putative mouse cleaning gene whose functions is to cleanse the cell of potentially deleterious endogenous metabolites and to modulate the accumulation of intermediates in biochemical pathways
UniProtKB/Swiss-Prot CatalyticActivity:
ADP-D-ribose + H(2)O = AMP + D-ribose 5-phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
ADP-sugar + H(2)O = AMP + alpha-D-aldose 5-phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
8-oxo-dGDP + H(2)O = 8-oxo-dGMP + phosphate.
UniProtKB/Swiss-Prot Function:
Hydrolyzes with similar activities ADP-ribose ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.

Enzyme Numbers (IUBMB) for NUDT5 Gene

Gene Ontology (GO) - Molecular Function for NUDT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 18462755
GO:0016787 hydrolase activity --
GO:0017110 nucleoside-diphosphatase activity IEA --
GO:0019144 ADP-sugar diphosphatase activity IDA 10567213
GO:0030515 snoRNA binding ISS --
genes like me logo Genes that share ontologies with NUDT5: view
genes like me logo Genes that share phenotypes with NUDT5: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NUDT5

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for NUDT5 Gene

Localization for NUDT5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUDT5 Gene COMPARTMENTS Subcellular localization image for NUDT5 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for NUDT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular NAS 10567213
GO:0005634 nucleus IDA 21630459
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with NUDT5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NUDT5 Gene

Pathways & Interactions for NUDT5 Gene

genes like me logo Genes that share pathways with NUDT5: view

Pathways by source for NUDT5 Gene

1 KEGG pathway for NUDT5 Gene

Gene Ontology (GO) - Biological Process for NUDT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process --
GO:0008152 metabolic process --
GO:0009117 nucleotide metabolic process NAS 10567213
GO:0009191 ribonucleoside diphosphate catabolic process IDA 18462755
GO:0019303 D-ribose catabolic process NAS 10567213
genes like me logo Genes that share ontologies with NUDT5: view

No data available for SIGNOR curated interactions for NUDT5 Gene

Drugs & Compounds for NUDT5 Gene

(2) Drugs for NUDT5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Magnesium Nutra 0

(11) Additional Compounds for NUDT5 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
8-oxo-dGDP
8-Oxo-dGMP
  • 8-Oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate
  • 8OG
Adenosine diphosphate ribose
  • (Rib5)ppA
  • 5-(Adenosine 5'-pyrophosphoryl)-D-ribose
  • A5'pp5Rib
  • Adenosine 5'-diphosphoribose
  • Adenosine diphosphate ribose
20762-30-5
D-Ribose 5-phosphate
  • D-Ribose 5-phosphate
  • D-Ribose-5-P
  • D-Ribose-5-phosphate
  • D-Ribose-5-phosphorate
  • D-Ribose-5-phosphoric acid
3615-55-2
D-Ribulose 5-phosphate
  • alpha-D-Ribose 5-phosphate
  • D-Ribulose 5-phosphate
  • Erythro-Pentulose 5-phosphate
  • Ribulose 5-phosphate
  • Ribulose phosphate
4151-19-3
genes like me logo Genes that share compounds with NUDT5: view

Transcripts for NUDT5 Gene

Unigene Clusters for NUDT5 Gene

Nudix (nucleoside diphosphate linked moiety X)-type motif 5:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NUDT5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT5 Gene

No ASD Table

Relevant External Links for NUDT5 Gene

GeneLoc Exon Structure for
NUDT5
ECgene alternative splicing isoforms for
NUDT5

Expression for NUDT5 Gene

mRNA expression in normal human tissues for NUDT5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NUDT5 Gene

This gene is overexpressed in Whole Blood (x4.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUDT5 Gene



SOURCE GeneReport for Unigene cluster for NUDT5 Gene Hs.555956

mRNA Expression by UniProt/SwissProt for NUDT5 Gene

Q9UKK9-NUDT5_HUMAN
Tissue specificity: Widely expressed. Most abundant in liver
genes like me logo Genes that share expression patterns with NUDT5: view

Protein tissue co-expression partners for NUDT5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues for NUDT5 Gene

Orthologs for NUDT5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NUDT5 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia NUDT5 35
  • 86.91 (n)
  • 90.87 (a)
NUDT5 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nudt5 35
  • 80.89 (n)
  • 82.57 (a)
Nudt5 16
Nudt5 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NUDT5 35
  • 99.24 (n)
  • 99.54 (a)
NUDT5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nudt5 35
  • 81.89 (n)
  • 86.3 (a)
cow
(Bos Taurus)
Mammalia NUDT5 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NUDT5 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUDT5 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC426368 35
  • 72.15 (n)
  • 70.32 (a)
NUDT5 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUDT5 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nudt5 35
  • 66.5 (n)
  • 69.27 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17284 35
zebrafish
(Danio rerio)
Actinopterygii nudt5 35
  • 64.04 (n)
  • 59.61 (a)
nudt5 36
  • 55 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9208 35
worm
(Caenorhabditis elegans)
Secernentea ndx-2 35
  • 46.56 (n)
  • 36.51 (a)
ndx-2 36
  • 32 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B09306g 35
  • 48.82 (n)
  • 43.72 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YSA1 35
  • 49.07 (n)
  • 44.44 (a)
YSA1 36
  • 33 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBP35G2.12 35
  • 48.62 (n)
  • 40.33 (a)
Species with no ortholog for NUDT5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUDT5 Gene

ENSEMBL:
Gene Tree for NUDT5 (if available)
TreeFam:
Gene Tree for NUDT5 (if available)

Paralogs for NUDT5 Gene

Pseudogenes.org Pseudogenes for NUDT5 Gene

genes like me logo Genes that share paralogs with NUDT5: view

No data available for Paralogs for NUDT5 Gene

Variants for NUDT5 Gene

Sequence variations from dbSNP and Humsavar for NUDT5 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1917132 -- 12,185,724(+) CAGAG(A/T)TCCAA intron-variant
rs1917133 -- 12,188,055(+) GGTCA(C/T)TTGGA intron-variant
rs1917134 -- 12,188,096(+) ATCAC(A/G)CCACT intron-variant
rs1996525 -- 12,193,026(-) TGGAG(A/C)TCACC intron-variant
rs1996526 -- 12,192,991(-) TAATT(A/C)CTCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUDT5 Gene

Variant ID Type Subtype PubMed ID
nsv5820 CNV Insertion 18451855

Variation tolerance for NUDT5 Gene

Residual Variation Intolerance Score: 39.93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.78; 16.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUDT5 Gene

HapMap Linkage Disequilibrium report
NUDT5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT5 Gene

Disorders for NUDT5 Gene

Relevant External Links for NUDT5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUDT5
genes like me logo Genes that share disorders with NUDT5: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUDT5 Gene

Publications for NUDT5 Gene

  1. Suppression of mutagenesis by 8-hydroxy-2'-deoxyguanosine 5'-triphosphate (7,8-dihydro-8-oxo-2'-deoxyguanosine 5'-triphosphate) by human MTH1, MTH2, and NUDT5. (PMID: 20144704) Hori M. … Kamiya H. (Free Radic. Biol. Med. 2010) 23 67
  2. Activation of NUDT5, an ADP-ribose pyrophosphatase, by nitric oxide-mediated ADP-ribosylation. (PMID: 17261271) Yu H.N. … Kim J.S. (Biochem. Biophys. Res. Commun. 2007) 23 67
  3. Human polynucleotide phosphorylase protein in response to oxidative stress. (PMID: 16716086) Hayakawa H. … Sekiguchi M. (Biochemistry 2006) 23 67
  4. Mammalian enzymes for preventing transcriptional errors caused by oxidative damage. (PMID: 16002790) Ishibashi T. … Sekiguchi M. (Nucleic Acids Res. 2005) 23 67
  5. A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides. (PMID: 12717453) Ishibashi T. … Sekiguchi M. (EMBO Rep. 2003) 23 67

Products for NUDT5 Gene

Sources for NUDT5 Gene

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