Aliases for NUDT5 Gene
External Ids for NUDT5 Gene
Previous GeneCards Identifiers for NUDT5 Gene
This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing 8-oxo-dADP and 8-oxo-dGDP. Protein-bound ADP ribose can be hazardous to the cell because it can modify some amino acid residues, resulting in the inhibition of ATP-activated potassium channels. 8-oxoGua is an oxidized form of guanine that can potentially alter genetic information by pairing with adenine and cytosine in RNA. Presence of 8-oxoGua in RNA results in formation of abnormal proteins due to translational errors. [provided by RefSeq, Aug 2013]
GeneCards Summary for NUDT5 Gene
NUDT5 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 5) is a Protein Coding gene. Among its related pathways are Metabolism and Purine metabolism (REACTOME). GO annotations related to this gene include magnesium ion binding and m7G(5)pppN diphosphatase activity.
UniProtKB/Swiss-Prot for NUDT5 Gene
Hydrolyzes with similar activities ADP-ribose ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.