NUDT5 Gene
protein-coding GIFtS: 54
GCID: GC10M012207
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nudix (nucleoside diphosphate linked moiety X)-type motif...
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Aliases
for NUDT5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 51 2 | | YSA12 | | YSA1H1 2 3 | | ADP-Sugar Pyrophosphatase2 | | HYSAH11 | | Nucleoside Diphosphate Linked Moiety X-Type Motif 52 | | Nucleoside Diphosphate-Linked Moiety X Motif 52 3 | | EC 3.6.1.133 | | Nudix Motif 52 3 | | EC 3.6.1.583 | | 8-Oxo-DGDP Phosphatase2 3 | | |
Export aliases for NUDT5 gene to outside databasesPrevious GC identifers: GC10M012153 GC10M012357 GC10M012213 GC10M012249 GC10M012126 |
Summaries
for NUDT5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NUDT5:
Nudix hydrolases, such as NUDT5, eliminate toxic nucleotide derivatives from the cell and regulate the levels ofimportant signaling nucleotides and their metabolites (McLennan, 1999 (PubMed 10373642)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: NUDT5_HUMAN, Q9UKK9Function: Hydrolyzes with similar activities ADP-ribose ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can alsohydrolyze other nucleotide sugars with low activity. Does not play a role in U8 snoRNA decapping activity. Binds U8snoRNA
Gene Wiki entry for NUDT5
|
Genomic Views
for NUDT5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_008705.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NUDT5 gene promoter:
STAT1 p53 NCX/Ncx SREBP-1c STAT1beta Ik-3 LCR-F1 STAT1alpha SREBP-1b SREBP-1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for NUDT5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUDT5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10p14 Ensembl cytogenetic band: 10p13 HGNC cytogenetic band: 10p14NUDT5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M012207: view genomic region
(about GC identifiers)
Start:
|
12,207,324 bp from pter |
End:
|
12,238,143 bp from pter |
Size:
|
30,820 bases |
Orientation:
|
minus strand |
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Proteins
for NUDT5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NUDT5_HUMAN, Q9UKK9 (See
protein sequence)Recommended Name: ADP-sugar pyrophosphatase Size: 219 amino acids; 24328 Da
Cofactor: Binds 3 magnesium ions per subunit
Subunit: Homodimer
6/7 PDB 3D structures from  and Proteopedia  for NUDT5 (see all 7):2DSB (3D)
2DSC (3D)
2DSD (3D)
3AC9 (3D)
3ACA (3D)
3BM4 (3D)
Secondary accessions: A8K516 Q6IAG0 Q9UH49Explore the universe of human proteins at neXtProt for NUDT5: NX_Q9UKK9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UKK9
NUDT5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_054861.2
ENSEMBL proteins: ENSP00000419628 ENSP00000368211 ENSP00000368219 ENSP00000436844 ENSP00000368222 ENSP00000368209 ENSP00000407856 ENSP00000445116 Reactome Protein details: Q9UKK9
Human Recombinant Protein Products for NUDT5:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
NUDT5 for ontologies About GeneDecksing
NUDT5 Antibody Products:
Assay Products for NUDT5: |
Protein
Domains /
Families
for NUDT5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NUDT5 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UKK9ProtoNet protein and cluster: Q9UKK9 1 Blocks protein family: IPB000086 NUDIX hydrolase
UniProtKB/Swiss-Prot: NUDT5_HUMAN, Q9UKK9Similarity: Belongs to the Nudix hydrolase familySimilarity: Contains 1 nudix hydrolase domain |
Function
for NUDT5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: NUDT5_HUMAN, Q9UKK9Function: Hydrolyzes with similar activities ADP-ribose ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can alsohydrolyze other nucleotide sugars with low activity. Does not play a role in U8 snoRNA decapping activity. Binds U8snoRNACatalytic activity: ADP-D-ribose + H(2)O = AMP + D-ribose 5-phosphateCatalytic activity: ADP-sugar + H(2)O = AMP + alpha-D-aldose 5-phosphateCatalytic activity: 8-oxo-dGDP + H(2)O = 8-oxo-dGMP + phosphate Genatlas biochemistry entry for NUDT5:nudix (nucleoside diphosphate linked moiety X)-type motif 5,hydrolase,NDP- sugar hydrolase,putative mouse cleaning genewhose functions is to cleanse the cell of potentially deleterious endogenous metabolites and to modulate theaccumulation of intermediates in biochemical pathways
Enzyme Numbers (IUBMB): EC 3.6.1.131 EC 3.6.1.581
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
NUDT5 for ontologies About GeneDecksing
Phenotypes:
1 MGI phenotypic allele  for Nudt5 (no phenotypes)
NUDT5 for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT5
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NUDT5 (NM_014142) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NUDT5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUDT5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT5 |
|
Pathways & Interactions
for NUDT5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Phosphate bond hydrolysis by NUDT proteins | | | 2 | Purine metabolism | | | 3 | Metabolism | | | 4 | Purine metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 
Reactome Pathways for NUDT5
1 
Kegg Pathway (Kegg details for NUDT5):
NUDT5 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NUDT5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 13)
5/39 Interacting proteins for NUDT5 (Q9UKK92, 3 ENSP000004196284) via UniProtKB, MINT, STRING, and/or I2D (see all 39)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
NUDT5 for ontologies About GeneDecksing
|
Drugs & Compounds
for NUDT5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
NUDT5 for compounds About GeneDecksing
 Browse Tocris compounds for NUDT5
6 HMDB Compounds for NUDT5 About this table
4 Novoseek chemical compound relationships for NUDT5 gene About this table
Search CenterWatch for drugs/clinical trials and news about NUDT5
|
Transcripts
for NUDT5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NUDT5 gene: NM_014142.2 Unigene Cluster for NUDT5: Nudix (nucleoside diphosphate linked moiety X)-type motif 5 Hs.555956 [show with all ESTs]Unigene Representative Sequence: CA45388510 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000491614 ENST00000378929 ENST00000378937 ENST00000378952 ENST00000476462
ENST00000378940 ENST00000378927 ENST00000498825 ENST00000444732 ENST00000537776(uc001ilj.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT5
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NUDT5 (NM_014142) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NUDT5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUDT5 |
Additional cDNA sequence: AF155832.1 AF161464.1 AF218818.1 AK291131.1 AK314144.1 BC000025.2 CR457195.1 23 DOTS entries: DT.417545 DT.451643 DT.100673352 DT.97806094 DT.95208640 DT.86852431 DT.100673353 DT.75156053 DT.95208643 DT.97839587 DT.100673350 DT.100673355 DT.92453911 DT.100673354 DT.100712772 DT.100873979 DT.102833492 DT.121284582 DT.121284653 DT.95266021 DT.121284680 DT.92453905 DT.95373278 24/471 AceView cDNA sequences (see all 471): BU845134 CB129678 BM809209 BM844032 BG256251 BE620813 AI185994 CA397725 BU195171 BE731804 CA773276 BE618326 BP870834 BE620279 CR622275 AA234971 AL556615 CA867355 BG470448 CF126462 BE894398 CB135047 BP871408 AA001923
GeneLoc Exon Structure
|
Expression
for NUDT5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NUDT5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAAATGCAAA
About this image
See NUDT5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NUDT5
SOURCE GeneReport for Unigene cluster: Hs.555956
UniProtKB/Swiss-Prot: NUDT5_HUMAN, Q9UKK9Tissue specificity: Widely expressed. Most abundant in liver
SABiosciences Custom PCR Arrays for NUDT5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUDT5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NUDT5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUDT5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUDT5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT5 |
Orthologs
for NUDT5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals and fungi.
Orthologs for NUDT5 gene from 7/19 species (see all 19) About this table
ENSEMBL Gene Tree for NUDT5 (if available)
TreeFam Gene Tree for NUDT5 (if available) |
Paralogs
for NUDT5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NUDT5 gene
NUDT5 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for NUDT5
PGOHUM00000243163
|
Genomic Variants
for NUDT5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NUDT5 (12207324 - 12238143 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NUDT5: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NUDT5 |
|
Disorders
/ Diseases
for NUDT5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 NUDT5 for disorders About MalaCards
NUDT5 for disorders About GeneDecksing
OMIM gene information: 609230
OMIM disorders: --
Export disorders for NUDT5 gene to outside databases
|
Publications
for NUDT5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NUDT5 gene, integrated from 9 sources (see all 33):
(articles sorted by number of sources associating them with NUDT5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning, expression and characterization of YSA1H, a human adenosine 5'-diphosphosugar pyrophosphatase possessing a MutT motif. (PubMed id 10567213)1, 2, 9 Gasmi L.... McLennan A.G. (1999)
- Molecular mechanism of ADP-ribose hydrolysis by human NUDT5 from structural and kinetic studies. (PubMed id 18462755)1, 2 Zha M....Ding J. (2008)
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
- Cloning and characterization of a new member of the Nudix hydrolases from human and mouse. (PubMed id 10722730)1, 2 Yang H.... Miller J.H. (2000)
- The MutT motif family of nucleotide phosphohydrolases in man and human pathogens (review). (PubMed id 10373642)1, 3 McLennan A.G. (1999)
- A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides. (PubMed id 12717453)1, 9 Ishibashi T....Sekiguchi M. (2003)
- Suppression of mutagenesis by 8-hydroxy-2'-deoxyguano sine 5'-triphosphate (7,8-dihydro-8-oxo-2'-deoxyguanosine 5'-triphosphate) by h uman MTH1, MTH2, and NUDT5. (PubMed id 20144704)1, 9 Hori M....Kamiya H. (2010)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
|
External Searches for NUDT5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NUDT5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NUDT5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NUDT5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NUDT5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NUDT5 gene:
Search GeneIP for patents involving NUDT5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NUDT5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| |
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| |  |  |  |  | | | | | | Recombinant Protein for NUDT5 |
|
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT5 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUDT5 |
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