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Aliases for NUDT4 Gene

Aliases for NUDT4 Gene

  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 4 2 3
  • Diphosphoinositol Polyphosphate Phosphohydrolase Type 2 2 3
  • Diadenosine 5,5-P1,P6-Hexaphosphate Hydrolase 2 3 4
  • DIPP-2 3 4
  • DIPP2 3 4
  • Diphosphoinositol Polyphosphate Phosphohydrolase 2 3
  • Nucleoside Diphosphate-Linked Moiety X Motif 4 4
  • Nudix Motif 4 4
  • EC 3.6.1.52 4
  • DIPP2alpha 3
  • EC 3.6.1.- 4
  • DIPP2beta 3
  • HDCMB47P 3
  • KIAA0487 4

External Ids for NUDT4 Gene

Previous GeneCards Identifiers for NUDT4 Gene

  • GC12P094293
  • GC12P093704
  • GC12P092274
  • GC12P093771

Summaries for NUDT4 Gene

Entrez Gene Summary for NUDT4 Gene

  • The protein encoded by this gene regulates the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to regulating intracellular trafficking. Several alternatively spliced transcript variants have been described, but the full-length nature of some variants has not been determined. Isoforms DIPP2alpha and DIPP2beta are distinguishable from each other solely by DIPP2beta possessing one additional amino acid due to intron boundary skidding in alternate splicing. [provided by RefSeq, Jul 2008]

GeneCards Summary for NUDT4 Gene

NUDT4 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 4) is a Protein Coding gene. Among its related pathways are Metabolism and Inositol phosphate metabolism (REACTOME). GO annotations related to this gene include snoRNA binding and diphosphoinositol-polyphosphate diphosphatase activity. An important paralog of this gene is NUDT11.

UniProtKB/Swiss-Prot for NUDT4 Gene

  • Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A. The major reaction products are ADP and p4a from Ap6A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.

Gene Wiki entry for NUDT4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT4 Gene

Genomics for NUDT4 Gene

Regulatory Elements for NUDT4 Gene

Genomic Location for NUDT4 Gene

Start:
93,377,883 bp from pter
End:
93,408,146 bp from pter
Size:
30,264 bases
Orientation:
Plus strand

Genomic View for NUDT4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUDT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT4 Gene

Proteins for NUDT4 Gene

  • Protein details for NUDT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZJ9-NUDT4_HUMAN
    Recommended name:
    Diphosphoinositol polyphosphate phosphohydrolase 2
    Protein Accession:
    Q9NZJ9
    Secondary Accessions:
    • B7Z916
    • Q4AEJ6
    • Q53EZ2
    • Q68DD7
    • Q9NPC5
    • Q9NS30
    • Q9NZK0
    • Q9NZK1

    Protein attributes for NUDT4 Gene

    Size:
    180 amino acids
    Molecular mass:
    20306 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 3 Mg(2+) or Mn(2+) ions per subunit.;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF75563.1; Type=Erroneous termination; Positions=181; Note=Translated as stop.; Evidence={ECO:0000305}; Sequence=BAE16985.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for NUDT4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUDT4 Gene

Proteomics data for NUDT4 Gene at MOPED

Post-translational modifications for NUDT4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NUDT4 Gene

Domains for NUDT4 Gene

Gene Families for NUDT4 Gene

HGNC:
  • NUDT :Nudix motif containing

Protein Domains for NUDT4 Gene

Suggested Antigen Peptide Sequences for NUDT4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZJ9

UniProtKB/Swiss-Prot:

NUDT4_HUMAN :
  • Q9NZJ9
Domain:
  • Contains 1 nudix hydrolase domain.
Family:
  • Belongs to the Nudix hydrolase family. DIPP subfamily.
genes like me logo Genes that share domains with NUDT4: view

Function for NUDT4 Gene

Molecular function for NUDT4 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=4.2 nM for PP-InsP5 {ECO:0000269 PubMed:10777568};
UniProtKB/Swiss-Prot CatalyticActivity: Diphospho-myo-inositol polyphosphate + H(2)O = myo-inositol polyphosphate + phosphate.
UniProtKB/Swiss-Prot Function: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A. The major reaction products are ADP and p4a from Ap6A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.

Enzyme Numbers (IUBMB) for NUDT4 Gene

Gene Ontology (GO) - Molecular Function for NUDT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity IDA 10777568
GO:0016787 hydrolase activity --
GO:0030515 snoRNA binding ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NUDT4: view

Phenotypes for NUDT4 Gene

genes like me logo Genes that share phenotypes with NUDT4: view

miRNA for NUDT4 Gene

miRTarBase miRNAs that target NUDT4

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for NUDT4 Gene

Localization for NUDT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDT4 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUDT4 Gene COMPARTMENTS Subcellular localization image for NUDT4 gene
Compartment Confidence
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for NUDT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular TAS 10777568
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NUDT4: view

Pathways for NUDT4 Gene

genes like me logo Genes that share pathways with NUDT4: view

Pathways by source for NUDT4 Gene

Gene Ontology (GO) - Biological Process for NUDT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0009187 cyclic nucleotide metabolic process TAS 10777568
GO:0019722 calcium-mediated signaling TAS 10777568
GO:0019935 cyclic-nucleotide-mediated signaling TAS 10777568
GO:0035556 intracellular signal transduction NAS 10777568
genes like me logo Genes that share ontologies with NUDT4: view

Compounds for NUDT4 Gene

(6) HMDB Compounds for NUDT4 Gene

Compound Synonyms Cas Number PubMed IDs
5-Diphosphoinositol pentakisphosphate
  • 5-diphospho-1D-myo-inositol pentakisphosphate
Not Available
Magnesium
  • Magnesium
7439-95-4
Manganese
  • manganese
7439-96-5
Myo-inositol hexakisphosphate
  • 1D-myo-Inositol 1,2,3,4,5,6-hexakisphosphate
83-86-3
Phosphate
  • NFB Orthophosphate
14265-44-2
genes like me logo Genes that share compounds with NUDT4: view

Transcripts for NUDT4 Gene

Unigene Clusters for NUDT4 Gene

Nudix (nucleoside diphosphate linked moiety X)-type motif 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d
SP1:
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - -
SP6: - - - - - - -
SP7: -

Relevant External Links for NUDT4 Gene

GeneLoc Exon Structure for
NUDT4
ECgene alternative splicing isoforms for
NUDT4

Expression for NUDT4 Gene

mRNA expression in normal human tissues for NUDT4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NUDT4 Gene

This gene is overexpressed in Heart - Left Ventricle (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUDT4 Gene

SOURCE GeneReport for Unigene cluster for NUDT4 Gene Hs.506325

mRNA Expression by UniProt/SwissProt for NUDT4 Gene

Q9NZJ9-NUDT4_HUMAN
Tissue specificity: Expressed in heart and, at lower level in skeletal muscle, pancreas and kidney.
genes like me logo Genes that share expressions with NUDT4: view

Orthologs for NUDT4 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUDT4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUDT4 35
  • 99.82 (n)
  • 100 (a)
NUDT4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 96 (a)
OneToMany
NUDT4 35
  • 91.9 (n)
  • 97.24 (a)
NUDT4 36
  • 97 (a)
OneToMany
dog
(Canis familiaris)
Mammalia NUDT4 35
  • 94.11 (n)
  • 98.34 (a)
NUDT4 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nudt4 35
  • 90.32 (n)
  • 96.65 (a)
Nudt4 16
Nudt4 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 61 (a)
ManyToMany
-- 36
  • 84 (a)
ManyToMany
-- 36
  • 73 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 96 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nudt4 35
  • 88.08 (n)
  • 95.53 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 88 (a)
OneToMany
NUDT4 35
  • 80.31 (n)
  • 93.96 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 94 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia nudt4 35
  • 80.19 (n)
  • 92.78 (a)
Str.6375 35
zebrafish
(Danio rerio)
Actinopterygii nudt4a 36
  • 62 (a)
ManyToMany
nudt4b 35
  • 68.79 (n)
  • 78.03 (a)
nudt4b 36
  • 76 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Aps 36
  • 53 (a)
OneToMany
CG6391 37
  • 58 (a)
worm
(Caenorhabditis elegans)
Secernentea Y92H12BL.5 36
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8787 36
  • 40 (a)
OneToMany
Species with no ortholog for NUDT4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUDT4 Gene

ENSEMBL:
Gene Tree for NUDT4 (if available)
TreeFam:
Gene Tree for NUDT4 (if available)

Paralogs for NUDT4 Gene

Paralogs for NUDT4 Gene

Selected SIMAP similar genes for NUDT4 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for NUDT4 Gene

genes like me logo Genes that share paralogs with NUDT4: view

Variants for NUDT4 Gene

Sequence variations from dbSNP and Humsavar for NUDT4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs12597 -- 93,402,649(+) TTTCA(A/G)TCTCA utr-variant-3-prime, downstream-variant-500B
rs2035052 -- 93,394,072(+) ATCTC(A/G)GTTCA intron-variant
rs2054300 -- 93,394,078(+) GTTCA(C/T)TGCAA intron-variant
rs2054301 -- 93,394,505(+) AAATA(G/T)TTTAA intron-variant
rs2054302 -- 93,394,506(+) AATAT(A/T)TTAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUDT4 Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER Inversion 18451855
nsv822 CNV Loss 18451855
esv23701 CNV Loss 19812545
nsv518120 CNV Loss 19592680

Relevant External Links for NUDT4 Gene

HapMap Linkage Disequilibrium report
NUDT4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT4 Gene

Disorders for NUDT4 Gene

No disorders were found for NUDT4 Gene.

No data available for UniProtKB/Swiss-Prot for NUDT4 Gene

Publications for NUDT4 Gene

  1. Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. The expanding NUDT family. (PMID: 10777568) Caffrey J.J. … Shears S.B. (J. Biol. Chem. 2000) 2 3 4 23
  2. Genetic rationale for microheterogeneity of human diphosphoinositol polyphosphate phosphohydrolase type 2. (PMID: 11376937) Caffrey J.J. … Shears S.B. (Gene 2001) 2 3 23
  3. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N. … Ohara O. (DNA Res. 1997) 3 4
  4. Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases. (PMID: 12121577) Leslie N.R. … Safrany S.T. (BMC Biochem. 2002) 3 4
  5. Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate. (PMID: 12370170) Fisher D.I. … Cartwright J.L. (J. Biol. Chem. 2002) 3 4

Products for NUDT4 Gene

Sources for NUDT4 Gene

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