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NUDT4 Gene

protein-coding   GIFtS: 56
GCID: GC12P093771

Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 41 2     Diphosphoinositol Polyphosphate Phosphohydrolase 22
Diphosphoinositol Polyphosphate Phosphohydrolase Type 21 2     EC 3.6.1.-3
Diadenosine 5',5'''-P1,P6-Hexaphosphate Hydrolase 22 3     EC 3.6.1.523
DIPP-22 3     KIAA04873
DIPP22 3     Nucleoside Diphosphate-Linked Moiety X Motif 43
DIPP2alpha2     Nudix Motif 43
DIPP2beta2     

External Ids:    HGNC: 80511   Entrez Gene: 111632   Ensembl: ENSG000001735987   OMIM: 6092295   UniProtKB: Q9NZJ93   

Export aliases for NUDT4 gene to outside databases

Previous GC identifers: GC12P093392 GC12P094293 GC12P093704 GC12P092274


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NUDT4 Gene:
The protein encoded by this gene regulates the turnover of diphosphoinositol polyphosphates. The turnover of these
high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory
consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to regulating intracellular
trafficking. Several alternatively spliced transcript variants have been described, but the full-length nature of
some variants has not been determined. Isoforms DIPP2alpha and DIPP2beta are distinguishable from each other
solely by DIPP2beta possessing one additional amino acid due to intron boundary skidding in alternate splicing.
(provided by RefSeq, Jul 2008)

GeneCards Summary for NUDT4 Gene:
NUDT4 (nudix (nucleoside diphosphate linked moiety X)-type motif 4) is a protein-coding gene. GO annotations related to this gene include diphosphoinositol-polyphosphate diphosphatase activity and snoRNA binding. An important paralog of this gene is NUDT11.

UniProtKB/Swiss-Prot: NUDT4_HUMAN, Q9NZJ9
Function: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate),
PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal
transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A. The major
reaction products are ADP and p4a from Ap6A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Does not play
a role in U8 snoRNA decapping activity. Binds U8 snoRNA

Gene Wiki entry for NUDT4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NUDT4 gene promoter:
         c-Fos   E2F-3a   E2F-4   E2F-5   Pbx1a   AP-1   E2F-2   FOXL1   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNUDT4 promoter sequence
   Search Chromatin IP Primers for NUDT4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NUDT4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q21   Ensembl cytogenetic band:  12q22   HGNC cytogenetic band: 12q21

NUDT4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUDT4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P093771:  view genomic region     (about GC identifiers)

Start:
93,771,659 bp from pter      End:
93,797,024 bp from pter
Size:
25,366 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NUDT4_HUMAN, Q9NZJ9 (See protein sequence)
Recommended Name: Diphosphoinositol polyphosphate phosphohydrolase 2  
Size: 180 amino acids; 20306 Da
Cofactor: Binds 3 magnesium or manganese ions per subunit (By similarity)
Sequence caution: Sequence=AAF75563.1; Type=Erroneous termination; Positions=181; Note=Translated as stop;
Sequence=BAE16985.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B7Z916 Q4AEJ6 Q53EZ2 Q68DD7 Q9NPC5 Q9NS30 Q9NZK0 Q9NZK1
Alternative splicing: 3 isoforms:  Q9NZJ9-1   Q9NZJ9-2   Q9NZJ9-3   

Explore the universe of human proteins at neXtProt for NUDT4: NX_Q9NZJ9

Explore proteomics data for NUDT4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NUDT4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_061967.3  NP_950241.1  

    ENSEMBL proteins: 
     ENSP00000338352   ENSP00000406612   ENSP00000448504   ENSP00000449552   ENSP00000449724  
     ENSP00000448032   ENSP00000448620  
    Reactome Protein details: Q9NZJ9

    NUDT4 Human Recombinant Protein Products:

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    antibodies-online proteins for NUDT4 (5 products) 

     
    antibodies-online peptides for NUDT4

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NUDT: Nudix motif containing

    3 InterPro protein domains:
     IPR015797 NUDIX_hydrolase_dom-like
     IPR020084 NUDIX_hydrolase_CS
     IPR000086 NUDIX_hydrolase_dom

    Graphical View of Domain Structure for InterPro Entry Q9NZJ9

    ProtoNet protein and cluster: Q9NZJ9

    1 Blocks protein domain: IPB000086 NUDIX hydrolase

    UniProtKB/Swiss-Prot: NUDT4_HUMAN, Q9NZJ9
    Similarity: Belongs to the Nudix hydrolase family. DIPP subfamily
    Similarity: Contains 1 nudix hydrolase domain


    Find genes that share domains with NUDT4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NUDT4_HUMAN, Q9NZJ9
    Function: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate),
    PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal
    transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A. The major
    reaction products are ADP and p4a from Ap6A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Does not play
    a role in U8 snoRNA decapping activity. Binds U8 snoRNA
    Catalytic activity: Diphospho-myo-inositol polyphosphate + H(2)O = myo-inositol polyphosphate + phosphate
    Biophysicochemical properties: Kinetic parameters: KM=4.2 nM for PP-InsP5;

         Enzyme Numbers (IUBMB): EC 3.6.1.521 EC 3.6.1.-1

         Gene Ontology (GO): Selected molecular function terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008486diphosphoinositol-polyphosphate diphosphatase activity IDA10777568
    GO:0016787hydrolase activity ----
    GO:0030515snoRNA binding ISS--
    GO:0046872metal ion binding IEA--
    GO:0050072NOT m7G(5')pppN diphosphatase activity ISS--
         
    Find genes that share ontologies with NUDT4           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for NUDT4:
     Decreased Hepatitis C virus re  Decreased influenza A/WSN/33 r 

         1 MGI phenotypic allele for Nudt4 (no phenotypes)

    Find genes that share phenotypes with NUDT4           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for NUDT4

    miRNA
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    miRTarBase miRNAs that target NUDT4:
    hsa-let-7f-5p (MIRT051407), hsa-let-7a-5p (MIRT052476)

    Block miRNA regulation of human, mouse, rat NUDT4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NUDT4 (see all 64):
    hsa-miR-429 hsa-miR-300 hsa-miR-411 hsa-miR-488 hsa-miR-371-5p hsa-miR-650 hsa-miR-124 hsa-miR-155
    SwitchGear 3'UTR luciferase reporter plasmidNUDT4 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NUDT4_HUMAN, Q9NZJ9: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular TAS10777568
    GO:0005829cytosol TAS--

    Find genes that share ontologies with NUDT4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NUDT4 About    
    See pathways by source

    SuperPathContained pathways About
    1Inositol phosphate metabolism (REACTOME)
    Inositol phosphate metabolism0.59
    Synthesis of pyrophosphates in the cytosol0.00
    2Metabolism
    Metabolism0.38


    Find genes that share SuperPaths with NUDT4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for NUDT4
        Synthesis of pyrophosphates in the cytosol


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NUDT4
    Interactions:

        Search GeneGlobe Interaction Network for NUDT4

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009187cyclic nucleotide metabolic process TAS10777568
    GO:0019722calcium-mediated signaling TAS10777568
    GO:0019935cyclic-nucleotide-mediated signaling TAS10777568
    GO:0035556intracellular signal transduction NAS10777568
    GO:0043647inositol phosphate metabolic process TAS--

    Find genes that share ontologies with NUDT4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for NUDT4

    6 HMDB Compounds for NUDT4    About this table
    CompoundSynonyms CAS #PubMed Ids
    5-Diphosphoinositol pentakisphosphate5-diphospho-1D-myo-inositol pentakisphosphate (see all 11)----
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--
    Myo-inositol hexakisphosphate1D-myo-Inositol 1,2,3,4,5,6-hexakisphosphate (see all 9)83-86-3--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NUDT4 gene (2 alternative transcripts): 
    NM_019094.4  NM_199040.2  

    Unigene Cluster for NUDT4:

    Nudix (nucleoside diphosphate linked moiety X)-type motif 4
    Hs.506325  [show with all ESTs]
    Unigene Representative Sequence: NM_199040
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000337179(uc010sup.2 uc010suq.2) ENST00000415493(uc001tcm.3 uc001tcn.3 uc001tco.3)
    ENST00000550056 ENST00000549992 ENST00000548662 ENST00000547014 ENST00000546925

    miRNA
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    Block miRNA regulation of human, mouse, rat NUDT4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NUDT4 (see all 64):
    hsa-miR-429 hsa-miR-300 hsa-miR-411 hsa-miR-488 hsa-miR-371-5p hsa-miR-650 hsa-miR-124 hsa-miR-155
    SwitchGear 3'UTR luciferase reporter plasmidNUDT4 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat NUDT4
      QuantiFast Probe-based Assays in human, mouse, rat NUDT4

    Additional mRNA sequence: 

    AB007956.2 AF067803.1 AF191649.1 AF191650.1 AF191651.1 AF191652.2 AF191653.1 AF191654.2 
    AF191655.1 AK223497.1 AK304296.1 AK315778.1 BC012069.1 BC051310.1 BT020109.1 BT020110.1 
    CR749445.1 DQ786307.1 

    Selected DOTS entries (see all 29):

    DT.40210800  DT.86840028  DT.95259475  DT.121198044  DT.121435918  DT.40308826  DT.92065288  DT.121198059 
    DT.121435664  DT.121436054  DT.86853326  DT.100821413  DT.100821421  DT.121435952  DT.97848820  DT.121198069 
    DT.211338  DT.91773944  DT.100821418  DT.100821424  DT.121198002  DT.121198068  DT.121198104  DT.121436035 

    Selected AceView cDNA sequences (see all 359):

    AA991646 CD678494 AI376220 AA385629 AA515713 AA425630 AA694237 BQ424378 
    BC012069 AA934879 BM683467 BM453188 AF191649 CA419106 BM750459 BU156892 
    BM718822 N40032 BX509404 F07356 F07321 BE348721 AA236258 BX483537 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NUDT4 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d
    SP1:                                                                                    
    SP2:        -     -     -     -     -     -                                             
    SP3:        -     -     -     -     -     -                                             
    SP4:              -     -     -     -     -                                             
    SP5:                          -     -     -                                             


    ECgene alternative splicing isoforms for NUDT4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NUDT4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCTCATTTG
    NUDT4 Expression
    About this image


    NUDT4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Hematopoietic System)
             Erythroblasts Hematopoietic Bone Marrow
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)
     
     Kidney (Urinary System)
    NUDT4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NUDT4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.506325

    UniProtKB/Swiss-Prot: NUDT4_HUMAN, Q9NZJ9
    Tissue specificity: Expressed in heart and, at lower level in skeletal muscle, pancreas and kidney

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NUDT4 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nudt41 , 5 nudix (nucleoside diphosphate linked moiety X)-type more1, 5 90.32(n)1
    96.65(a)1
      10 (49.42 cM)5
    712071  NM_027722.41  NP_081998.31 
     955470075 
    chicken
    (Gallus gallus)
    Aves NUDT41 nudix (nucleoside diphosphate linked moiety X)-type more 80.31(n)
    93.96(a)
      417897  XM_416139.4  XP_416139.4 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    94(a)
    1 → many
    5(31478850-31494149)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.63752 Transcribed sequence with moderate similarity to protein more 80.37(n)    BX719605.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nudt4b1 nudix (nucleoside diphosphate linked moiety X)-type more 68.79(n)
    78.03(a)
      447910  NM_001004648.1  NP_001004648.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG63913 diphosphoinositol-polyphosphate
    diphosphatase
    58(a)   67F3   --
    worm
    (Caenorhabditis elegans)
    Secernentea Y92H12BL.56
    Protein Y92H12BL.5 (Y92H12BL.5) mRNA, complete cds...
    38(a)
    1 → many
    I(1365309-1375883) WBGene00022366


    ENSEMBL Gene Tree for NUDT4 (if available)
    TreeFam Gene Tree for NUDT4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NUDT4 gene
    NUDT112  NUDT32  NUDT102  
    4 SIMAP similar genes for NUDT4 using alignment to 3 protein entries:     NUDT4_HUMAN (see all proteins):
    NUDT11    NUDT10    NUDT3    RPS10-NUDT3

    Find genes that share paralogs with NUDT4           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for NUDT4
    PGOHUM00000261098 PGOHUM00000234430 PGOHUM00000244201


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NUDT4 (see all 534)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1809645641,2
    --93612054(+) AGATCC/GCCTGA 2 -- us2k10--------
    rs1496303041,2
    --93612078(+) AGACCA/TGCCTG 2 -- us2k10--------
    rs1471856921,2
    C--93612112(+) CTACT-/AAAAAA 2 -- us2k10--------
    rs125805561,2
    C,F,H--93612147(+) ggcatG/Acaact 2 -- us2k13Minor allele frequency- A:0.08NA EA 242
    rs1125800111,2
    F--93612235(+) AACAGC/TACCAT 2 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1842736611,2
    --93612291(+) ATGTGA/GACCAA 2 -- us2k10--------
    rs1886941791,2
    --93612320(+) CACATA/GTTAGC 2 -- us2k10--------
    rs1400231731,2
    --93612332(+) ATAGCA/GGACTC 2 -- us2k10--------
    rs1419900551,2
    C--93612380(+) GGACAA/TAGTTA 2 -- us2k10--------
    rs792620281,2
    C,F--93612382(+) ACATAG/CTTAAA 2 -- us2k12Minor allele frequency- C:0.08NA 122

    HapMap Linkage Disequilibrium report for NUDT4 (93771659 - 93797024 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for NUDT4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv822CNV Loss18451855
    esv23701CNV Loss19812545
    nsv518120CNV Loss19592680
    nsv7234OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NUDT4
    DNA2.0 Custom Variant and Variant Library Synthesis for NUDT4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609229    OMIM disorders: --


    Find genes that share disorders with NUDT4           About GenesLikeMe


    Export disorders for NUDT4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NUDT4 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with NUDT4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. The expanding NUDT family. (PubMed id 10777568)1, 2, 3, 9 Caffrey J.J.... Shears S.B. (J. Biol. Chem. 2000)
    2. Genetic rationale for microheterogeneity of human diphosphoinositol polyphosphate phosphohydrolase type 2. (PubMed id 11376937)1, 3, 9 Caffrey J.J. and Shears S.B. (Gene 2001)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate. (PubMed id 12370170)1, 2 Fisher D.I.... Cartwright J.L. (J. Biol. Chem. 2002)
    5. Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases. (PubMed id 12121577)1, 2 Leslie N.R.... Safrany S.T. (BMC Biochem. 2002)
    6. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)1, 2 Seki N.... Ohara O. (DNA Res. 1997)
    7. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. Genome-scale RNAi screen for host factors required for HIV replication. (PubMed id 18976975)1 Zhou H....Espeseth A.S. (amp 2008)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11163 HGNC: 8051 AceView: NUDT4 Ensembl:ENSG00000173598 euGenes: HUgn11163
    ECgene: NUDT4 H-InvDB: NUDT4

    (According to HUGE)
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    HUGE: KIAA0487

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NUDT4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NUDT4 gene:
    Search GeneIP for patents involving NUDT4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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