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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NUDT4 Gene

protein-coding   GIFtS: 53
GCID: GC12P093771

Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif...

  Search for NUDT4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 41 2     Diphosphoinositol Polyphosphate Phosphohydrolase 22
Diphosphoinositol Polyphosphate Phosphohydrolase Type 21 2     EC 3.6.1.-3
Diadenosine 5',5'''-P1,P6-Hexaphosphate Hydrolase 22 3     EC 3.6.1.523
DIPP-22 3     KIAA04873
DIPP22 3     Nucleoside Diphosphate-Linked Moiety X Motif 43
DIPP2alpha2     Nudix Motif 43
DIPP2beta2     

External Ids:    HGNC: 80511   Entrez Gene: 111632   Ensembl: ENSG000001735987   OMIM: 6092295   UniProtKB: Q9NZJ93   

Export aliases for NUDT4 gene to outside databases

Previous GC identifers: GC12P093392 GC12P094293 GC12P093704 GC12P092274


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NUDT4 Gene:
The protein encoded by this gene regulates the turnover of diphosphoinositol polyphosphates. The turnover of these
high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory
consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to regulating intracellular
trafficking. Several alternatively spliced transcript variants have been described, but the full-length nature of
some variants has not been determined. Isoforms DIPP2alpha and DIPP2beta are distinguishable from each other
solely by DIPP2beta possessing one additional amino acid due to intron boundary skidding in alternate splicing.
(provided by RefSeq, Jul 2008)

GeneCards Summary for NUDT4 Gene: 
NUDT4 (nudix (nucleoside diphosphate linked moiety X)-type motif 4) is a protein-coding gene. Among its related super-pathways are Synthesis of IP3 and IP4 in the cytosol and inositol pyrophosphates biosynthesis. GO annotations related to this gene include diphosphoinositol-polyphosphate diphosphatase activity and snoRNA binding. An important paralog of this gene is NUDT11.

UniProtKB/Swiss-Prot: NUDT4_HUMAN, Q9NZJ9
Function: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate),
PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal
transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A. The major
reaction products are ADP and p4a from Ap6A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Does not play
a role in U8 snoRNA decapping activity. Binds U8 snoRNA

Gene Wiki entry for NUDT4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NUDT4 gene promoter:
         c-Fos   E2F-3a   E2F-4   E2F-5   Pbx1a   AP-1   E2F-2   FOXL1   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNUDT4 promoter sequence
   Search SABiosciences Chromatin IP Primers for NUDT4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUDT4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q21   Ensembl cytogenetic band:  12q22   HGNC cytogenetic band: 12q21

NUDT4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUDT4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P093771:  view genomic region     (about GC identifiers)

Start:
93,771,659 bp from pter      End:
93,797,024 bp from pter
Size:
25,366 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NUDT4_HUMAN, Q9NZJ9 (See protein sequence)
Recommended Name: Diphosphoinositol polyphosphate phosphohydrolase 2  
Size: 180 amino acids; 20306 Da
Cofactor: Binds 3 magnesium or manganese ions per subunit (By similarity)
Subcellular location: Cytoplasm
Sequence caution: Sequence=AAF75563.1; Type=Erroneous termination; Positions=181; Note=Translated as stop;
Sequence=BAE16985.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B7Z916 Q4AEJ6 Q53EZ2 Q68DD7 Q9NPC5 Q9NS30 Q9NZK0 Q9NZK1
Alternative splicing: 3 isoforms:  Q9NZJ9-1   Q9NZJ9-2   Q9NZJ9-3   

Explore the universe of human proteins at neXtProt for NUDT4: NX_Q9NZJ9

Explore proteomics data for NUDT4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NZJ9

  • NUDT4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NUDT4 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_061967.3  NP_950241.1  

    ENSEMBL proteins: 
     ENSP00000338352   ENSP00000406612   ENSP00000448504   ENSP00000449552   ENSP00000449724  
     ENSP00000448032   ENSP00000448620  
    Reactome Protein details: Q9NZJ9
    Human Recombinant Protein Products for NUDT4: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NUDT4 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular TAS10777568
    GO:0005829cytosol TAS--

    NUDT4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    NUDT: Nudix motif containing

    3 InterPro protein domains:
     IPR015797 NUDIX_hydrolase_dom-like
     IPR020084 NUDIX_hydrolase_CS
     IPR000086 NUDIX_hydrolase_dom

    Graphical View of Domain Structure for InterPro Entry Q9NZJ9

    ProtoNet protein and cluster: Q9NZJ9

    1 Blocks protein domain: IPB000086 NUDIX hydrolase

    UniProtKB/Swiss-Prot: NUDT4_HUMAN, Q9NZJ9
    Similarity: Belongs to the Nudix hydrolase family. DIPP subfamily
    Similarity: Contains 1 nudix hydrolase domain


    NUDT4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NUDT4_HUMAN, Q9NZJ9
    Function: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate),
    PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal
    transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A. The major
    reaction products are ADP and p4a from Ap6A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Does not play
    a role in U8 snoRNA decapping activity. Binds U8 snoRNA
    Catalytic activity: Diphospho-myo-inositol polyphosphate + H(2)O = myo-inositol polyphosphate + phosphate
    Biophysicochemical properties: Kinetic parameters: KM=4.2 nM for PP-InsP5;

         Enzyme Numbers (IUBMB): EC 3.6.1.521 EC 3.6.1.-1

         Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008486diphosphoinositol-polyphosphate diphosphatase activity IDA10777568
    GO:0016787hydrolase activity ----
    GO:0030515snoRNA binding ISS--
    GO:0046872metal ion binding IEA--
    GO:0050072NOT m7G(5')pppN diphosphatase activity ISS--
         
    NUDT4 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for NUDT4:
     Decreased Hepatitis C virus re  Decreased influenza A/WSN/33 r 

         1 MGI phenotypic allele for Nudt4 (no phenotypes)

    NUDT4 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NUDT4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NUDT4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NUDT4 
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    hsa-miR-429 hsa-miR-300 hsa-miR-411 hsa-miR-488 hsa-miR-371-5p hsa-miR-650 hsa-miR-124 hsa-miR-155
    SwitchGear 3'UTR luciferase reporter plasmidNUDT4 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NUDT4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Synthesis of IP3 and IP4 in the cytosol
    Inositol phosphate metabolism0.57
    2inositol pyrophosphates biosynthesis
    Synthesis of pyrophosphates in the cytosol0.42
    3Metabolism
    Metabolism0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3        Reactome Pathways for NUDT4
        Metabolism
    Synthesis of pyrophosphates in the cytosol
    Inositol phosphate metabolism



    NUDT4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NUDT4

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009187cyclic nucleotide metabolic process TAS10777568
    GO:0019722calcium-mediated signaling TAS10777568
    GO:0019935cyclic-nucleotide-mediated signaling TAS10777568
    GO:0035556intracellular signal transduction NAS10777568
    GO:0043647inositol phosphate metabolic process TAS--

    NUDT4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NUDT4

    6 HMDB Compounds for NUDT4    About this table
    CompoundSynonyms CAS #PubMed Ids
    5-Diphosphoinositol pentakisphosphate5-diphospho-1D-myo-inositol pentakisphosphate (see all 11)----
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--
    Myo-inositol hexakisphosphate1D-myo-Inositol 1,2,3,4,5,6-hexakisphosphate (see all 9)83-86-3--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Search CenterWatch for drugs/clinical trials and news about NUDT4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NUDT4 gene (2 alternative transcripts): 
    NM_019094.4  NM_199040.2  

    Unigene Cluster for NUDT4:

    Nudix (nucleoside diphosphate linked moiety X)-type motif 4
    Hs.506325  [show with all ESTs]
    Unigene Representative Sequence: NM_199040
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000337179(uc010sup.2 uc010suq.2) ENST00000415493(uc001tcm.3 uc001tcn.3 uc001tco.3)
    ENST00000550056 ENST00000549992 ENST00000548662 ENST00000547014 ENST00000546925

    miRNA
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    8/64 QIAGEN miScript miRNA Assays for microRNAs that regulate NUDT4 (see all 64):
    hsa-miR-429 hsa-miR-300 hsa-miR-411 hsa-miR-488 hsa-miR-371-5p hsa-miR-650 hsa-miR-124 hsa-miR-155
    SwitchGear 3'UTR luciferase reporter plasmidNUDT4 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB007956.2 AF067803.1 AF191649.1 AF191650.1 AF191651.1 AF191652.2 AF191653.1 AF191654.2 
    AF191655.1 AK223497.1 AK304296.1 AK315778.1 BC012069.1 BC051310.1 BT020109.1 BT020110.1 
    CR749445.1 DQ786307.1 

    24/29 DOTS entries (see all 29):

    DT.40210800  DT.86840028  DT.95259475  DT.121198044  DT.121435918  DT.40308826  DT.92065288  DT.121198059 
    DT.121435664  DT.121436054  DT.86853326  DT.100821413  DT.100821421  DT.121435952  DT.97848820  DT.121198069 
    DT.211338  DT.91773944  DT.100821418  DT.100821424  DT.121198002  DT.121198068  DT.121198104  DT.121436035 

    24/359 AceView cDNA sequences (see all 359):

    CA419106 AI263311 AA343412 AA425630 BU178582 AW242707 AA385629 F07321 
    NM_019094 AW029024 AI368080 BM995246 AI312875 AF191650 AA515713 BM718822 
    BP337349 AA694237 BM800009 BM424219 AA991646 BG674515 AI263361 AA287829 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for NUDT4 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d
    SP1:                                                                                    
    SP2:        -     -     -     -     -     -                                             
    SP3:        -     -     -     -     -     -                                             
    SP4:              -     -     -     -     -                                             
    SP5:                          -     -     -                                             


    ECgene alternative splicing isoforms for NUDT4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NUDT4 expression in normal human tissues (normalized intensities)      NUDT4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCTCATTTG
    NUDT4 Expression
    About this image


    NUDT4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Heart (Cardiovascular System)
             left ventricular apex samples   
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Thyroid (Endocrine System)

    See NUDT4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NUDT4

    SOURCE GeneReport for Unigene cluster: Hs.506325

    UniProtKB/Swiss-Prot: NUDT4_HUMAN, Q9NZJ9
    Tissue specificity: Expressed in heart and, at lower level in skeletal muscle, pancreas and kidney

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NUDT4 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nudt41 , 5 nudix (nucleoside diphosphate linked moiety X)-type more1, 5 90.32(n)1
    96.65(a)1
      10 (49.42 cM)5
    712071  NM_027722.41  NP_081998.31 
     955470075 
    chicken
    (Gallus gallus)
    Aves NUDT41 nudix (nucleoside diphosphate linked moiety X)-type more 79.95(n)
    93.92(a)
      417897  XM_001231431.1  XP_001231432.2 
    lizard
    (Anolis carolinensis)
    Reptilia NUDT46
    Uncharacterized protein
    94(a)
    1 → many
    5(31478850-31494149)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.63752 Transcribed sequence with moderate similarity to protein more 80.37(n)    BX719605.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nudt4b1 nudix (nucleoside diphosphate linked moiety X)-type more 68.79(n)
    78.03(a)
      447910  NM_001004648.1  NP_001004648.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG63913
    Aps1
    diphosphoinositol-polyphosphate
    diphosphatase3
    Aps1
    58(a)3
    56.84(n)1
    58.33(a)1
      67F33
    392261  NM_140164.21  NP_648421.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y92H12BL.56
    Protein Y92H12BL.5
    38(a)
    1 → many
    I(1365309-1375883)


    ENSEMBL Gene Tree for NUDT4 (if available)
    TreeFam Gene Tree for NUDT4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NUDT4 gene
    NUDT112  NUDT32  NUDT102  
    3 SIMAP similar genes for NUDT4 using alignment to 3 protein entries:     NUDT4_HUMAN (see all proteins):
    NUDT11    NUDT10    NUDT3

    NUDT4 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for NUDT4
    PGOHUM00000261098 PGOHUM00000234430 PGOHUM00000244201


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/534 SNPs in NUDT4 are shown (see all 534)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1809645641,2
    --93612054(+) AGATCC/GCCTGA 2 -- us2k10--------
    rs1496303041,2
    --93612078(+) AGACCA/TGCCTG 2 -- us2k10--------
    rs1471856921,2
    C--93612112(+) CTACT-/AAAAAA 2 -- us2k10--------
    rs125805561,2
    C,F,H--93612147(+) ggcatG/Acaact 2 -- us2k13Minor allele frequency- A:0.08NA EA 242
    rs1125800111,2
    F--93612235(+) AACAGC/TACCAT 2 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1842736611,2
    --93612291(+) ATGTGA/GACCAA 2 -- us2k10--------
    rs1886941791,2
    --93612320(+) CACATA/GTTAGC 2 -- us2k10--------
    rs1400231731,2
    --93612332(+) ATAGCA/GGACTC 2 -- us2k10--------
    rs1419900551,2
    C--93612380(+) GGACAA/TAGTTA 2 -- us2k10--------
    rs792620281,2
    C,F--93612382(+) ACATAG/CTTAAA 2 -- us2k12Minor allele frequency- C:0.08NA 122

    HapMap Linkage Disequilibrium report for NUDT4 (93771659 - 93797024 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for NUDT4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv822CNV Loss18451855
    esv23701CNV Loss19812545
    nsv518120CNV Loss19592680
    nsv7234OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NUDT4 for disorders           About MalaCards
    OMIM gene information: 609229    OMIM disorders: --


    NUDT4 for disorders           About GeneDecksing


    Export disorders for NUDT4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NUDT4 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with NUDT4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. The expanding NUDT family. (PubMed id 10777568)1, 2, 3, 9 Caffrey J.J.... Shears S.B. (2000)
    2. Genetic rationale for microheterogeneity of human diphosphoinositol polyphosphate phosphohydrolase type 2. (PubMed id 11376937)1, 3, 9 Caffrey J.J. and Shears S.B. (2001)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate. (PubMed id 12370170)1, 2 Fisher D.I.... Cartwright J.L. (2002)
    5. Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases. (PubMed id 12121577)1, 2 Leslie N.R.... Safrany S.T. (2002)
    6. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)1, 2 Seki N.... Ohara O. (1997)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    10. Lineage-specific gene duplication and loss in human and great ape evolution. (PubMed id 15252450)1 Fortna A....Sikela J.M. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11163 HGNC: 8051 AceView: NUDT4 Ensembl:ENSG00000173598 euGenes: HUgn11163
    ECgene: NUDT4 H-InvDB: NUDT4

    (According to HUGE)
    About This Section
    HUGE: KIAA0487

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NUDT4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NUDT4 gene:
    Search GeneIP for patents involving NUDT4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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