Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NUDT4 Gene

protein-coding   GIFtS: 53
GCID: GC12P093771

nudix (nucleoside diphosphate linked moiety X)-type motif...
  Search for NUDT4
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NUDT4    

Aliases
for NUDT4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 41 2     HDCMB47P1
DIPP21 2 3     Diphosphoinositol Polyphosphate Phosphohydrolase 22
DIPP2alpha1 2     Diphosphoinositol Polyphosphate Phosphohydrolase Type 22
DIPP2beta1 2     EC 3.6.1.-3
KIAA04871 3     EC 3.6.1.523
Diadenosine 5',5'''-P1,P6-Hexaphosphate Hydrolase 22 3     Nucleoside Diphosphate-Linked Moiety X Motif 43
DIPP-22 3     Nudix Motif 43

External Ids:    HGNC: 80511   Entrez Gene: 111632   Ensembl: ENSG000001735987   OMIM: 6092295   UniProtKB: Q9NZJ93   

Export aliases for NUDT4 gene to outside databases

Previous GC identifers: GC12P093392 GC12P094293 GC12P093704 GC12P092274


Summaries
for NUDT4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NUDT4:
The protein encoded by this gene regulates the turnover of diphosphoinositol polyphosphates. The turnover of these
high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory
consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to regulating intracellular
trafficking. Several alternatively spliced transcript variants have been described, but the full-length nature of some
variants has not been determined. Isoforms DIPP2alpha and DIPP2beta are distinguishable from each other solely by
DIPP2beta possessing one additional amino acid due to intron boundary skidding in alternate splicing. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NUDT4_HUMAN, Q9NZJ9
Function: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate),
PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal
transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A. The major
reaction products are ADP and p4a from Ap6A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Does not play a
role in U8 snoRNA decapping activity. Binds U8 snoRNA

Gene Wiki entry for NUDT4


Genomic Views
for NUDT4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NUDT4 gene promoter:
         c-Fos   E2F-3a   E2F-4   E2F-5   Pbx1a   AP-1   E2F-2   FOXL1   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NUDT4 promoter sequence
   Search SABiosciences Chromatin IP Primers for NUDT4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUDT4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q21   Ensembl cytogenetic band:  12q22   HGNC cytogenetic band: 12q21

NUDT4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUDT4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P093771:  view genomic region     (about GC identifiers)

Start:
 93,771,659 bp from pter      End:
 93,797,024 bp from pter
Size:
 25,366 bases      Orientation:
 plus strand

Proteins
for NUDT4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NUDT4_HUMAN, Q9NZJ9 (See protein sequence)
Recommended Name: Diphosphoinositol polyphosphate phosphohydrolase 2  
Size: 180 amino acids; 20306 Da
Cofactor: Binds 3 magnesium or manganese ions per subunit (By similarity)
Subcellular location: Cytoplasm
Sequence caution: Sequence=AAF75563.1; Type=Erroneous termination; Positions=181; Note=Translated as stop;
Sequence=BAE16985.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B7Z916 Q4AEJ6 Q53EZ2 Q68DD7 Q9NPC5 Q9NS30 Q9NZK0 Q9NZK1
Alternative splicing: 3 isoforms:  Q9NZJ9-1   Q9NZJ9-2   Q9NZJ9-3   

Explore the universe of human proteins at neXtProt for NUDT4: NX_Q9NZJ9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NZJ9

    • NUDT4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_061967.3  NP_950241.1  

    ENSEMBL proteins: 
     ENSP00000338352   ENSP00000406612   ENSP00000448504   ENSP00000449552   ENSP00000449724  
     ENSP00000448032   ENSP00000448620  
    Reactome Protein details: Q9NZJ9
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: NUDT4
    OriGene Protein Over-expression Lysate: NUDT4
    OriGene Custom Protein Services for NUDT4 
    GenScript Custom Purified and Recombinant Proteins Services for NUDT4
    Novus Biologicals NUDT4 Protein
    Novus Biologicals NUDT4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NUDT4

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular TAS10777568
    GO:0005737cytoplasm IEA--


    NUDT4 for ontologies           About GeneDecksing



    NUDT4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NUDT4 
    GenScript Custom Superior Antibodies Services for NUDT4
    Novus Biologicals NUDT4 Antibodies
    Search for Antibodies for NUDT4 at Abcam  
    Uscn Antibodies for NUDT4
    Search ThermoFisher Antibodies for NUDT4

    Assay Products for NUDT4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NUDT4
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for NUDT4

    Protein Domains /
    Families
    for NUDT4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NUDT4 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015797 NUDIX_hydrolase_dom-like
     IPR020084 NUDIX_hydrolase_CS
     IPR000086 NUDIX_hydrolase_dom

    Graphical View of Domain Structure for InterPro Entry Q9NZJ9

    ProtoNet protein and cluster: Q9NZJ9

    1 Blocks protein family: IPB000086 NUDIX hydrolase

    UniProtKB/Swiss-Prot: NUDT4_HUMAN, Q9NZJ9
    Similarity: Belongs to the Nudix hydrolase family. DIPP subfamily
    Similarity: Contains 1 nudix hydrolase domain


    Function
    for NUDT4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NUDT4_HUMAN, Q9NZJ9
    Function: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate),
    PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal
    transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A. The major
    reaction products are ADP and p4a from Ap6A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Does not play a
    role in U8 snoRNA decapping activity. Binds U8 snoRNA
    Catalytic activity: Diphospho-myo-inositol polyphosphate + H(2)O = myo-inositol polyphosphate + phosphate
    Biophysicochemical properties: Kinetic parameters: KM=4.2 nM for PP-InsP5;

    Enzyme Numbers (IUBMB): EC 3.6.1.521 EC 3.6.1.-1

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): NUDT4
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NUDT4
    8/64 QIAGEN miScript miRNA Assays for microRNAs that regulate NUDT4 (see all 64):
    hsa-miR-429 hsa-miR-300 hsa-miR-411 hsa-miR-488 hsa-miR-371-5p hsa-miR-650 hsa-miR-124 hsa-miR-155
    SwitchGear 3'UTR luciferase reporter plasmid: NUDT4 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NUDT4 (see all 7)
    OriGene shRNA RFP: NUDT4
    OriGene siRNA: NUDT4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUDT4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NUDT4

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT4 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT4 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): NUDT4 (NM_199040)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUDT4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUDT4 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for NUDT4
    Search LifeMap BioReagents cell lines for NUDT4

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT4

    Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008486diphosphoinositol-polyphosphate diphosphatase activity IDA10777568
    GO:0016787hydrolase activity ----
    GO:0030515snoRNA binding ISS--
    GO:0046872metal ion binding IEA--
    GO:0050072NOT m7G(5')pppN diphosphatase activity ISS--


    NUDT4 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for NUDT4:
     Decreased Hepatitis C virus re  Decreased influenza A/WSN/33 r 

    Animal Models:
         1 MGI phenotypic allele for Nudt4 (no phenotypes)

    NUDT4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NUDT4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Metabolism
    		Metabolism1.00
    2Synthesis of IP3 and IP4 in the cytosol
    		Inositol phosphate metabolism0.57
    3inositol pyrophosphates biosynthesis
    		Synthesis of pyrophosphates in the cytosol0.42

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for NUDT4
        Metabolism
    Synthesis of pyrophosphates in the cytosol
    Inositol phosphate metabolism



    NUDT4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NUDT4

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009187cyclic nucleotide metabolic process TAS10777568
    GO:0019722calcium-mediated signaling TAS10777568
    GO:0019935cyclic-nucleotide-mediated signaling TAS10777568
    GO:0035556intracellular signal transduction NAS10777568
    GO:0046831regulation of RNA export from nucleus TAS10777568


    NUDT4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NUDT4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NUDT4

    6 HMDB Compounds for NUDT4    About this table
    CompoundSynonyms CAS #PubMed Ids
    5-Diphosphoinositol pentakisphosphate5-diphospho-1D-myo-inositol pentakisphosphate (see all 11)----
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--
    Myo-inositol hexakisphosphate1D-myo-Inositol 1,2,3,4,5,6-hexakisphosphate (see all 9)83-86-3--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    Search CenterWatch for drugs/clinical trials and news about NUDT4 

    Transcripts
    for NUDT4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NUDT4 gene (2 alternative transcripts): 
    NM_019094.4  NM_199040.2  

    Unigene Cluster for NUDT4:

    Nudix (nucleoside diphosphate linked moiety X)-type motif 4
    Hs.506325  [show with all ESTs]
    Unigene Representative Sequence: NM_199040
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000337179(uc010sup.2 uc010suq.2) ENST00000415493(uc001tcm.3 uc001tcn.3 uc001tco.3)
    ENST00000550056 ENST00000549992 ENST00000548662 ENST00000547014 ENST00000546925


    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): NUDT4
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NUDT4
    8/64 QIAGEN miScript miRNA Assays for microRNAs that regulate NUDT4 (see all 64):
    hsa-miR-429 hsa-miR-300 hsa-miR-411 hsa-miR-488 hsa-miR-371-5p hsa-miR-650 hsa-miR-124 hsa-miR-155
    SwitchGear 3'UTR luciferase reporter plasmid: NUDT4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NUDT4 (see all 7)
    OriGene shRNA RFP: NUDT4
    OriGene siRNA: NUDT4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUDT4
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT4 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT4 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): NUDT4 (NM_199040)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUDT4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUDT4 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUDT4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat NUDT4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUDT4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUDT4

    Additional cDNA sequence: 

    AB007956.2 AF067803.1 AF191649.1 AF191650.1 AF191651.1 AF191652.2 AF191653.1 AF191654.2 
    AF191655.1 AK223497.1 AK304296.1 AK315778.1 BC012069.1 BC051310.1 BT020109.1 BT020110.1 
    CR749445.1 DQ786307.1 

    24/29 DOTS entries (see all 29):

    DT.40210800  DT.86840028  DT.95259475  DT.121198044  DT.121435918  DT.40308826  DT.92065288  DT.121198059 
    DT.121435664  DT.121436054  DT.86853326  DT.100821413  DT.100821421  DT.121435952  DT.97848820  DT.121198068 
    DT.121198069  DT.211338  DT.91773944  DT.100821418  DT.100821424  DT.121198002  DT.121198104  DT.121436035 

    24/359 AceView cDNA sequences (see all 359):

    BX509404 BE219861 AW316658 AW029024 AF191649 AA236258 AA694237 BG674515 
    N40032 AI337281 CD520108 F07356 AI280172 AA343412 AA515713 AA425630 
    CA419106 BM800009 AW242707 AI376220 AF191650 BX483537 AW183089 BM453188 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for NUDT4 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d
    SP1:                                                                                    
    SP2:        -     -     -     -     -     -                                             
    SP3:        -     -     -     -     -     -                                             
    SP4:              -     -     -     -     -                                             
    SP5:                          -     -     -                                             


    ECgene alternative splicing isoforms for NUDT4

    Expression
    for NUDT4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NUDT4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTCTCATTTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NUDT4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Yolk SacDefinitive Yolk SacErythroid Progenitor CellsBlood
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)

    See NUDT4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NUDT4

    SOURCE GeneReport for Unigene cluster: Hs.506325

    UniProtKB/Swiss-Prot: NUDT4_HUMAN, Q9NZJ9
    Tissue specificity: Expressed in heart and, at lower level in skeletal muscle, pancreas and kidney

        SABiosciences Custom PCR Arrays for NUDT4
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUDT4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat NUDT4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUDT4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUDT4
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT4

    Orthologs
    for NUDT4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NUDT4 gene from 9/24 species (see all 24)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Nudt41 , 5 nudix (nucleoside diphosphate linked moiety X)-type more1, 5 90.32(n)1
    96.65(a)1    		   10 (49.42 cM)5
    712071  NM_027722.41  NP_081998.31 
     955470075 
    chicken
    (Gallus gallus)    		 Aves NUDT41 nudix (nucleoside diphosphate linked moiety X)-type more 79.95(n)
    93.92(a)    		   417897  XM_001231431.1  XP_001231432.2 
    lizard
    (Anolis carolinensis)    		 Reptilia NUDT46
    		 --
    		 94(a)
    		 1 → many
    		 5(31478853-31493709)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.63752 Transcribed sequence with moderate similarity to protein more 80.37(n)    BX719605.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii nudt4b1 nudix (nucleoside diphosphate linked moiety X)-type more 68.79(n)
    78.03(a)    		   447910  NM_001004648.1  NP_001004648.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG63913
    Aps1    		 diphosphoinositol-polyphosphate
    diphosphatase3
    Aps1    		 58(a)3
    56.84(n)1
    58.33(a)1    		   67F33
    392261  NM_140164.21  NP_648421.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y92H12BL.56
    		 --
    		 37(a)
    		 1 → many
    		 I(1365311-1375885)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons NUDT186
    atnudt126
    (see all 7)    		 nudix hydrolase 12
    (see all 7)    		 26(a)
    25(a)
    (see all 7)    		 many ↔ many
    many ↔ many
    (see all 7)    		 1(5124742-5126151)
    1(4389751-4391151)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 7)    		 hydrolase, NUDIX family, domain containing protein...
    hydrolase, NUDIX family, domain containing protein...
    (see all 7)    		 27(a)
    26(a)
    (see all 7)    		 many ↔ many
    many ↔ many
    (see all 7)    		 2(30619799-30621022)
    6(8067592-8069045)


    ENSEMBL Gene Tree for NUDT4 (if available)
    TreeFam Gene Tree for NUDT4 (if available) 

    Paralogs
    for NUDT4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NUDT4 gene
    NUDT112  NUDT32  NUDT102  
    3 SIMAP similar genes for NUDT4 using alignment to 3 protein entries:     NUDT4_HUMAN (see all proteins):
    NUDT11    NUDT10    NUDT3

    NUDT4 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for NUDT4
    PGOHUM00000261098 PGOHUM00000234430 PGOHUM00000244201


    Genomic Variants
    for NUDT4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/453 NCBI SNPs in NUDT4 are shown (see all 453)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1809645641,2
    		--93769725(+) AGATCC/GCCTGA 3 -- us2k1 int10--------
    rs1496303041,2
    		--93769749(+) AGACCA/TGCCTG 3 -- int1 us2k10--------
    rs1471856921,2
    		C,--93769783(+) CTACT-/AAAAAA 3 -- us2k1 int10--------
    rs125805561,2
    		C,H,--93769818(+) ggcatG/Acaact 3 -- us2k1 int13Minor allele frequency- A:0.08NA EA 242
    rs1125800111,2
    		--93769906(+) AACAGC/TACCAT 3 -- us2k1 int11Minor allele frequency- T:0.50CSA 2
    rs1842736611,2
    		--93769962(+) ATGTGA/GACCAA 3 -- us2k1 int10--------
    rs1886941791,2
    		--93769991(+) CACATA/GTTAGC 3 -- us2k1 int10--------
    rs1400231731,2
    		--93770003(+) ATAGCA/GGACTC 3 -- int1 us2k10--------
    rs1419900551,2
    		--93770051(+) GGACAA/TAGTTA 3 -- int1 us2k10--------
    rs792620281,2
    		C,--93770053(+) ACATAG/CTTAAA 3 -- int1 us2k12Minor allele frequency- C:0.08NA 122

    HapMap Linkage Disequilibrium report for NUDT4 (93771659 - 93797024 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for NUDT4
         4 CNVs: 66301 86520 76122 39111
         1 Indel: 86521

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NUDT4
    DNA2.0 Custom Variant and Variant Library Synthesis for NUDT4

    Disorders / Diseases
    for NUDT4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NUDT4 for disorders           About MalaCards

    NUDT4 for disorders           About GeneDecksing

    OMIM gene information: 609229    OMIM disorders: --


    Export disorders for NUDT4 gene to outside databases

    Publications
    for NUDT4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NUDT4 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with NUDT4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. The expanding NUDT family. (PubMed id 10777568)1, 2, 3, 9 Caffrey J.J.... Shears S.B. (2000)
    2. Genetic rationale for microheterogeneity of human diphosphoinositol polyphosphate phosphohydrolase type 2. (PubMed id 11376937)1, 3, 9 Caffrey J.J. and Shears S.B. (2001)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate. (PubMed id 12370170)1, 2 Fisher D.I.... Cartwright J.L. (2002)
    5. Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases. (PubMed id 12121577)1, 2 Leslie N.R.... Safrany S.T. (2002)
    6. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)1, 2 Seki N.... Ohara O. (1997)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    10. Lineage-specific gene duplication and loss in human and great ape evolution. (PubMed id 15252450)1 Fortna A....Sikela J.M. (2004)

    External Searches for NUDT4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NUDT4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11163 HGNC: 8051 AceView: NUDT4 Ensembl:ENSG00000173598 euGenes: HUgn11163
    ECgene: NUDT4 H-InvDB: NUDT4

    Other Databases showing NUDT4 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0487

    Specialized Databases showing NUDT4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NUDT4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NUDT4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NUDT4 gene:
    Search GeneIP for patents involving NUDT4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for NUDT4 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for NUDT4  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NUDT4   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUDT4  
     OriGene Protein Over-expression Lysate for NUDT4   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for NUDT4   OriGene 3'-UTR Clone for NUDT4  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT4   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT4  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for NUDT4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NUDT4   OriGene Custom Protein Services for NUDT4  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NUDT4
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NUDT4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUDT4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUDT4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUDT4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUDT4
     GenScript Custom Purified and Recombinant Proteins Services for NUDT4 GenScript cDNA clones with any tag delivered in your preferred vector for NUDT4
     GenScript Custom Assay Services for NUDT4 GenScript Custom Superior Antibodies Services for NUDT4
     GenScript Custom overexpressing Cell Line Services for NUDT4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NUDT4 promoter
     Search Chromatin IP Primers for NUDT4
     RT2 qPCR Primer Assay in human, mouse / rat NUDT4
     Search GNC Networks for NUDT4
     SABiosciences Custom PCR Arrays for NUDT4
     Search Tocris compounds for NUDT4
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NUDT4 antibodies
     NUDT4 proteins
     NUDT4 lysates
     Search for Antibodies for NUDT4 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for NUDT4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     NUDT4 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for NUDT4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT4
     SwitchGear 3'UTR luciferase reporter plasmids for NUDT4
     SwitchGear Promoter luciferase reporter plasmids for NUDT4
     Search ThermoFisher Antibodies for NUDT4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUDT4
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      NUDT4 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4