Aliases for NUDT3 Gene
Aliases for NUDT3 Gene
External Ids for NUDT3 Gene
- HGNC: 8050
- Entrez Gene: 11165
- Ensembl: ENSG00000272325
- OMIM: 609228
- UniProtKB: O95989
Previous GeneCards Identifiers for NUDT3 Gene
- GC06M034258
- GC06M034302
- GC06M034363
- GC06M033978
- GC06M034388
- GC06M034894
- GC06M035232
- GC06M035727
- GC06M034550
- GC06M035568
- GC06M036281
- GC06M036655
- GC06M037008
- GC06M037358
- GC06M037711
Summaries for NUDT3 Gene
-
NUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act as homeostatic checkpoints at important stages in nucleoside phosphate metabolic pathways, guarding against elevated levels of potentially dangerous intermediates, like 8-oxo-dGTP, which promotes AT-to-CG transversions (Safrany et al., 1998 [PubMed 9822604]).[supplied by OMIM, Feb 2011]
GeneCards Summary for NUDT3 Gene
NUDT3 (Nudix Hydrolase 3) is a Protein Coding gene. Among its related pathways are Metabolism and Inositol phosphate metabolism (REACTOME). Gene Ontology (GO) annotations related to this gene include hydrolase activity and diphosphoinositol-polyphosphate diphosphatase activity. An important paralog of this gene is NUDT4B.
UniProtKB/Swiss-Prot for NUDT3 Gene
-
Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphophate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT3 Gene
Genomics for NUDT3 Gene
GeneHancer (GH) Regulatory Elements for NUDT3 Gene
Promoters and enhancers for NUDT3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around NUDT3 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for NUDT3 Gene
Genomic Locations for NUDT3 Gene
- chr6:34,279,679-34,392,680
- (GRCh38/hg38)
- Size:
- 113,002 bases
- Orientation:
- Minus strand
- chr6:34,247,456-34,360,457
- (GRCh37/hg19)
Genomic View for NUDT3 Gene
Genes around NUDT3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p21.31 by Ensembl
- 6p21.31 by Entrez Gene
- 6p21.31 by HGNC
NUDT3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NUDT3 Gene
Proteins for NUDT3 Gene
-
Protein details for NUDT3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O95989-NUDT3_HUMAN
- Recommended name:
- Diphosphoinositol polyphosphate phosphohydrolase 1
- Protein Accession:
- O95989
- B2R8N4
Protein attributes for NUDT3 Gene
- Size:
- 172 amino acids
- Molecular mass:
- 19471 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Monomer.
Protein Expression for NUDT3 Gene
Post-translational modifications for NUDT3 Gene
No Post-translational modifications
Other Protein References for NUDT3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for NUDT3
- Novus Biologicals Antibodies for NUDT3
- Invitrogen Antibodies for NUDT3
- GeneTex NUDT3 antibody for NUDT3
-
Santa Cruz Biotechnology (SCBT) Antibodies for NUDT3
Protein Products
-
OriGene Purified Proteins for NUDT3
- Search Origene for MassSpec and Protein Over-expression Lysates for NUDT3
- Origene Custom Protein Services for NUDT3
- ProSpec Recombinant Proteins for NUDT3
- Search GeneTex for Proteins for NUDT3
-
Abcam proteins for NUDT3
Assay Products
No data available for DME Specific Peptides for NUDT3 Gene
Domains & Families for NUDT3 Gene
Gene Families for NUDT3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for NUDT3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for NUDT3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O95989- Family:
-
- Belongs to the Nudix hydrolase family. DIPP subfamily.
Function for NUDT3 Gene
Molecular function for NUDT3 Gene
- GENATLAS Biochemistry:
- nudix (nucleoside diphosphate linked moiety X)-type motif 3,hydrolase,most predominantly expressed in brain,heart,pancreas,liver,putative mouse cleaning gene whose functions is to cleanse the cell of potentially deleterious endogenous metabolites and to modulate the accumulation of intermediates in biochemical pathways
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=5.9 uM for Ap6A {ECO:0000269 PubMed:10419486, ECO:0000269 PubMed:12370170, ECO:0000269 PubMed:9822604}; KM=7.7 uM for Ap5A {ECO:0000269 PubMed:10419486, ECO:0000269 PubMed:12370170, ECO:0000269 PubMed:9822604}; KM=38 mM for 5-phosphoribose 1-diphosphate {ECO:0000269 PubMed:10419486, ECO:0000269 PubMed:12370170, ECO:0000269 PubMed:9822604}; KM=4.2 nM for PP-InsP5 {ECO:0000269 PubMed:10419486, ECO:0000269 PubMed:12370170, ECO:0000269 PubMed:9822604}; pH dependence: Optimum pH is 7-7.5. {ECO:0000269 PubMed:10419486, ECO:0000269 PubMed:12370170, ECO:0000269 PubMed:9822604};
- UniProtKB/Swiss-Prot CatalyticActivity:
- Diphospho-myo-inositol polyphosphate + H(2)O = myo-inositol polyphosphate + phosphate.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by fluoride and InsP6.
- UniProtKB/Swiss-Prot Function:
- Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphophate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.
Enzyme Numbers (IUBMB) for NUDT3 Gene
Phenotypes From GWAS Catalog for NUDT3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000287 | magnesium ion binding | IDA | 19585659 |
| GO:0000298 | endopolyphosphatase activity | IBA | -- |
| GO:0008486 | diphosphoinositol-polyphosphate diphosphatase activity | IDA,TAS | 10585413 |
| GO:0016787 | hydrolase activity | IEA | -- |
| GO:0034431 | bis(5-adenosyl)-hexaphosphatase activity | IBA | -- |
Phenotypes for NUDT3 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for NUDT3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for NUDT3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NUDT3 gene
- Search ViGene Biosciences for NUDT3
CRISPR Products
-
OriGene CRISPR knockouts for NUDT3
- genomics-online: gRNA clones - Search results for available NUDT3 gene related products
- Applied Biological Materials CRISPR for NUDT3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NUDT3
- GenScript: Design CRISPR guide RNA sequences for NUDT3
miRNA for NUDT3 Gene
- miRTarBase miRNAs that target NUDT3
-
- hsa-mir-766-3p (MIRT039048)
- hsa-mir-16-5p (MIRT051285)
- hsa-mir-4753-3p (MIRT317588)
- hsa-mir-4768-5p (MIRT317589)
- hsa-mir-6809-3p (MIRT317590)
- hsa-mir-6833-3p (MIRT317591)
- hsa-mir-3941 (MIRT317605)
- hsa-mir-221-5p (MIRT317620)
- hsa-mir-8073 (MIRT317637)
- hsa-mir-617 (MIRT360631)
- hsa-mir-6505-3p (MIRT360638)
- hsa-mir-136-5p (MIRT440077)
- hsa-mir-203b-3p (MIRT443893)
- hsa-mir-7158-3p (MIRT443894)
- hsa-mir-31-5p (MIRT443895)
- hsa-mir-100-3p (MIRT443896)
- hsa-mir-526b-5p (MIRT449053)
- hsa-mir-557 (MIRT471885)
- hsa-mir-507 (MIRT471886)
- hsa-mir-7703 (MIRT471887)
- hsa-mir-4325 (MIRT471888)
- hsa-mir-4699-5p (MIRT471889)
- hsa-mir-9500 (MIRT471890)
- hsa-mir-6873-5p (MIRT471891)
- hsa-mir-5096 (MIRT522102)
- hsa-mir-5587-5p (MIRT522103)
- hsa-mir-6855-5p (MIRT522104)
- hsa-mir-3170 (MIRT522105)
- hsa-mir-197-3p (MIRT522106)
- hsa-mir-6832-5p (MIRT522107)
- hsa-mir-6801-5p (MIRT522108)
- hsa-mir-1273f (MIRT522109)
- hsa-mir-1279 (MIRT522110)
- hsa-mir-484 (MIRT522111)
- hsa-mir-3155b (MIRT522112)
- hsa-mir-3155a (MIRT522113)
- hsa-mir-6890-5p (MIRT522114)
- hsa-mir-129-5p (MIRT522115)
- hsa-mir-4282 (MIRT522116)
- hsa-mir-8055 (MIRT522117)
- hsa-mir-500b-3p (MIRT609119)
- hsa-mir-1912 (MIRT609120)
- hsa-mir-1295b-5p (MIRT609121)
- hsa-mir-603 (MIRT609122)
- hsa-mir-362-3p (MIRT609123)
- hsa-mir-329-3p (MIRT609124)
- hsa-mir-8485 (MIRT609125)
- hsa-mir-4708-5p (MIRT609126)
- hsa-mir-6088 (MIRT609127)
- hsa-mir-4770 (MIRT609128)
- hsa-mir-143-3p (MIRT609129)
- hsa-mir-5006-3p (MIRT623046)
- hsa-mir-4755-5p (MIRT623047)
- hsa-mir-5089-5p (MIRT623048)
- hsa-mir-211-5p (MIRT623049)
- hsa-mir-204-5p (MIRT623050)
- hsa-mir-623 (MIRT623051)
- hsa-mir-6832-3p (MIRT623052)
- hsa-mir-3938 (MIRT623053)
- hsa-mir-493-5p (MIRT630981)
- hsa-mir-6878-3p (MIRT639030)
- hsa-mir-7973 (MIRT639031)
- hsa-mir-6744-3p (MIRT639032)
- hsa-mir-4757-5p (MIRT639033)
- hsa-mir-7114-3p (MIRT639034)
- hsa-mir-1180-5p (MIRT639035)
- hsa-mir-3922-3p (MIRT639036)
- hsa-mir-3176 (MIRT639037)
- hsa-mir-372-5p (MIRT639038)
- hsa-mir-371a-5p (MIRT639039)
- hsa-mir-616-5p (MIRT639040)
- hsa-mir-373-5p (MIRT639041)
- hsa-mir-371b-5p (MIRT639042)
- hsa-mir-6747-3p (MIRT639043)
- hsa-mir-1224-3p (MIRT639044)
- hsa-mir-6513-3p (MIRT639045)
- hsa-mir-1253 (MIRT655688)
- hsa-mir-6794-3p (MIRT655689)
- hsa-mir-4653-3p (MIRT655690)
- hsa-mir-8082 (MIRT655691)
- hsa-mir-4534 (MIRT655692)
- hsa-mir-4639-3p (MIRT655693)
- hsa-mir-6514-5p (MIRT655694)
- hsa-mir-6734-3p (MIRT667127)
- hsa-mir-9-3p (MIRT667128)
- hsa-mir-4524a-3p (MIRT667129)
- hsa-mir-302a-5p (MIRT667130)
- hsa-mir-6758-3p (MIRT667131)
- hsa-mir-4797-5p (MIRT667132)
- hsa-mir-4422 (MIRT667133)
- hsa-mir-4312 (MIRT701290)
- hsa-mir-6778-3p (MIRT701291)
- hsa-mir-150-5p (MIRT701292)
- hsa-mir-212-5p (MIRT701293)
- hsa-mir-186-3p (MIRT701294)
- hsa-mir-520h (MIRT701295)
- hsa-mir-520g-3p (MIRT701296)
- hsa-mir-512-3p (MIRT701297)
- hsa-mir-520e (MIRT701298)
- hsa-mir-520d-3p (MIRT701299)
- hsa-mir-520c-3p (MIRT701300)
- hsa-mir-520b (MIRT701301)
- hsa-mir-520a-3p (MIRT701302)
- hsa-mir-373-3p (MIRT701303)
- hsa-mir-372-3p (MIRT701304)
- hsa-mir-302e (MIRT701305)
- hsa-mir-302d-3p (MIRT701306)
- hsa-mir-302c-3p (MIRT701307)
- hsa-mir-302b-3p (MIRT701308)
- hsa-mir-302a-3p (MIRT701309)
- hsa-mir-93-5p (MIRT701310)
- hsa-mir-526b-3p (MIRT701311)
- hsa-mir-519d-3p (MIRT701312)
- hsa-mir-20b-5p (MIRT701313)
- hsa-mir-20a-5p (MIRT701314)
- hsa-mir-17-5p (MIRT701315)
- hsa-mir-106b-5p (MIRT701316)
- hsa-mir-106a-5p (MIRT701317)
- hsa-mir-4659b-3p (MIRT720369)
- hsa-mir-4659a-3p (MIRT720370)
- hsa-mir-6875-3p (MIRT720371)
- hsa-mir-4291 (MIRT720372)
- hsa-mir-7157-5p (MIRT720373)
- hsa-mir-4310 (MIRT720374)
- hsa-mir-1179 (MIRT720375)
- hsa-mir-6835-3p (MIRT720376)
- hsa-mir-548e-5p (MIRT720377)
- hsa-mir-1233-5p (MIRT736253)
- hsa-mir-30c-1-3p (MIRT739829)
- hsa-mir-30c-2-3p (MIRT739872)
- hsa-mir-338-5p (MIRT741361)
- hsa-mir-4456 (MIRT744734)
- hsa-mir-4786-5p (MIRT748879)
- hsa-mir-5007-3p (MIRT749427)
- hsa-mir-541-3p (MIRT750380)
- hsa-mir-633 (MIRT752661)
- hsa-mir-654-5p (MIRT753451)
- hsa-mir-6731-5p (MIRT754022)
- hsa-mir-6769a-5p (MIRT755194)
- hsa-mir-6769b-5p (MIRT755241)
- hsa-mir-6778-5p (MIRT755449)
- hsa-mir-6788-5p (MIRT755981)
- hsa-mir-6871-5p (MIRT758029)
- hsa-mir-6878-5p (MIRT758219)
- hsa-mir-7705 (MIRT759740)
- hsa-mir-8085 (MIRT760226)
- hsa-mir-92a-2-5p (MIRT760573)
- hsa-mir-122-5p (MIRT761346)
- hsa-mir-1267 (MIRT761757)
- hsa-mir-143-5p (MIRT762694)
- hsa-mir-192-5p (MIRT763441)
- hsa-mir-200c-5p (MIRT763676)
- hsa-mir-215-5p (MIRT763854)
- hsa-mir-3135b (MIRT764942)
- hsa-mir-34a-5p (MIRT765764)
- hsa-mir-34c-5p (MIRT765825)
- hsa-mir-3616-3p (MIRT766086)
- hsa-mir-3622b-5p (MIRT766164)
- hsa-mir-3652 (MIRT766303)
- hsa-mir-3664-5p (MIRT766516)
- hsa-mir-367-5p (MIRT766712)
- hsa-mir-4423-5p (MIRT768864)
- hsa-mir-4430 (MIRT768938)
- hsa-mir-4436b-3p (MIRT769114)
- hsa-mir-449a (MIRT769773)
- hsa-mir-449b-5p (MIRT769791)
- hsa-mir-4632-5p (MIRT770486)
- hsa-mir-4714-5p (MIRT771410)
- hsa-mir-504-3p (MIRT773065)
- hsa-mir-514a-5p (MIRT773425)
- hsa-mir-5190 (MIRT773608)
- hsa-mir-550a-3p (MIRT774595)
- hsa-mir-550b-3p (MIRT774623)
- hsa-mir-5693 (MIRT775040)
- hsa-mir-5698 (MIRT775159)
- hsa-mir-6499-3p (MIRT776325)
- hsa-mir-6501-5p (MIRT776529)
- hsa-mir-6728-3p (MIRT777934)
- hsa-mir-6735-5p (MIRT778032)
- hsa-mir-6805-3p (MIRT779523)
- hsa-mir-6828-3p (MIRT779948)
- hsa-mir-6879-5p (MIRT780804)
- hsa-mir-7106-3p (MIRT781316)
- hsa-mir-744-3p (MIRT781719)
- hsa-mir-767-3p (MIRT781934)
- hsa-mir-7843-5p (MIRT782108)
miRNA Products
- Search ViGene Biosciences for NUDT3
Inhibitory RNA Products
- Origene shrna, RNAi, and sirna products in human, mouse, rat for NUDT3
- Browse OriGene Inhibitory RNA Products For NUDT3
- genomics-online: shRNA clones - Search results for available NUDT3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for NUDT3 gene
Clone Products
- Sino Biological Human cDNA Clone for NUDT3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for NUDT3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NUDT3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available NUDT3 gene related products
- orf clones - Search results for available NUDT3 gene related products
- Applied Biological Materials Clones for NUDT3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for NUDT3
-
ViGene Biosciences adenoviral particle packaged cDNA for NUDT3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for NUDT3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NUDT3 gene
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUDT3 Gene
Localization for NUDT3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NUDT3 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 4 |
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | -- |
| GO:0005737 | cytoplasm | IBA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0070062 | extracellular exosome | IDA,HDA | 23376485 |
Pathways & Interactions for NUDT3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Inositol phosphate metabolism (REACTOME) | ||
| 2 | Metabolism |
.37
|
|
Pathways by source for NUDT3 Gene
3 Reactome pathways for NUDT3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007267 | cell-cell signaling | TAS | 10419486 |
| GO:0015961 | diadenosine polyphosphate catabolic process | TAS | 10419486 |
| GO:0043647 | inositol phosphate metabolic process | TAS | -- |
| GO:0071544 | diphosphoinositol polyphosphate catabolic process | IDA | 10585413 |
| GO:1901907 | diadenosine pentaphosphate catabolic process | IBA | -- |
No data available for SIGNOR curated interactions for NUDT3 Gene
Drugs & Compounds for NUDT3 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 5-Diphosphoinositol pentakisphosphate |
|
|
|
|||
| Diadenosine hexaphosphate |
|
56983-23-4 |
|
|||
| Myo-inositol hexakisphosphate |
|
83-86-3 |
|
|||
| Phosphate |
|
14265-44-2 |
|
Transcripts for NUDT3 Gene
mRNA/cDNA for NUDT3 Gene
- (1) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (4) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for NUDT3 Gene
- Nudix (nucleoside diphosphate linked moiety X)-type motif 3:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for NUDT3
- genomics-online: gRNA clones - Search results for available NUDT3 gene related products
- Applied Biological Materials CRISPR for NUDT3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NUDT3
- GenScript: Design CRISPR guide RNA sequences for NUDT3
miRNA Products
- Search ViGene Biosciences for NUDT3
Inhibitory RNA Products
- Origene shrna, RNAi, and sirna products in human, mouse, rat for NUDT3
- Browse OriGene Inhibitory RNA Products For NUDT3
- genomics-online: shRNA clones - Search results for available NUDT3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for NUDT3 gene
Clone Products
- Sino Biological Human cDNA Clone for NUDT3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for NUDT3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NUDT3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available NUDT3 gene related products
- orf clones - Search results for available NUDT3 gene related products
- Applied Biological Materials Clones for NUDT3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for NUDT3 Gene
This gene is overexpressed in Peripheral blood mononuclear cells (11.6) and Fetal Brain (6.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NUDT3 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of NUDT3 Gene:
NUDT3SOURCE GeneReport for Unigene cluster for NUDT3 Gene:
Hs.188882mRNA Expression by UniProt/SwissProt for NUDT3 Gene:
O95989-NUDT3_HUMAN
Tissue specificity:
Widely expressed. Expressed at higher level in brain, heart, pancreas and liver. Also expressed in placenta, lung and kidney.
Evidence on tissue expression from TISSUES for NUDT3 Gene
- Nervous system(4.8)
- Lung(3.1)
Primer Products
-
OriGene qPCR primer pairs for NUDT3
-
OriGene qPCR primer pairs and template standards for NUDT3
- genomics-online: primer clones - Search results for available NUDT3 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUDT3 Gene
Orthologs for NUDT3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | RPS10 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | NUDT3 33 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | NUDT3 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | NUDT3 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | NUDT3 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Nudt3 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Nudt3 33 |
|
||
| chicken (Gallus gallus) |
Aves | NUDT3 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | NUDT3 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | nudt3a 34 |
|
OneToMany | |
| nudt3b 33 34 |
|
||||
| zgc55746 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.7396 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG6391 35 |
|
|
|
| Aps 33 34 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009901 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | Y92H12BL.5 33 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.8787 34 |
|
OneToMany |
- Species where no ortholog for NUDT3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for NUDT3 Gene
Variants for NUDT3 Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000010018 | -- | 34,329,049(-) | G/A | intron_variant | |
| rs1000045434 | -- | 34,388,209(-) | A/G | intron_variant | |
| rs1000059920 | -- | 34,368,519(-) | A/G/T | intron_variant | |
| rs1000096375 | -- | 34,341,028(-) | A/G | intron_variant | |
| rs1000097815 | -- | 34,294,657(-) | C/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv10618n54 | CNV | loss | 21841781 |
| dgv10619n54 | CNV | loss | 21841781 |
| dgv10620n54 | CNV | loss | 21841781 |
| dgv10621n54 | CNV | loss | 21841781 |
| dgv10622n54 | CNV | loss | 21841781 |
| dgv10623n54 | CNV | loss | 21841781 |
| dgv1115e199 | CNV | deletion | 23128226 |
| esv2674771 | CNV | deletion | 23128226 |
| esv2731907 | CNV | deletion | 23290073 |
| esv29044 | CNV | loss | 19812545 |
| esv33496 | CNV | loss | 17666407 |
| esv3425871 | CNV | insertion | 20981092 |
| esv3567619 | CNV | deletion | 23714750 |
| esv3608655 | CNV | loss | 21293372 |
| esv3608656 | CNV | loss | 21293372 |
| esv3608657 | CNV | loss | 21293372 |
| nsv1034978 | CNV | gain | 25217958 |
| nsv473801 | CNV | novel sequence insertion | 20440878 |
| nsv5253 | CNV | insertion | 18451855 |
| nsv602863 | CNV | loss | 21841781 |
| nsv602886 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
46.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.67;
14.27% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NUDT3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- NUDT3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT3 Gene
Disorders for NUDT3 Gene
Additional Disease Information for NUDT3
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for NUDT3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUDT3 Gene
Publications for NUDT3 Gene
- A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase. (PMID: 9822604) Safrany ST … Shears SB (The EMBO journal 1998) 2 3 4 22 58
- Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate. (PMID: 12370170) Fisher DI … Cartwright JL (The Journal of biological chemistry 2002) 3 4 22 58
- The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein. (PMID: 10419486) Safrany ST … Shears SB (The Journal of biological chemistry 1999) 3 4 22 58
- Identification of 15 loci influencing height in a Korean population. (PMID: 19893584) Kim JJ … Lee JK (Journal of human genetics 2010) 3 44 58
- Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PMID: 20935630) Speliotes EK … Loos RJ (Nature genetics 2010) 3 44 58
Products for NUDT3 Gene
- Browse R&D Systems for Antibodies
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- Browse Proteome Profiler Antibody Arrays
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- Custom Antibody ServicesOriGene Antibodies for NUDT3
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for NUDT3
- Search Origene for MassSpec and Protein Over-expression Lysates for NUDT3
- Origene Custom Protein Services for NUDT3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NUDT3
- Browse OriGene Inhibitory RNA Products For NUDT3
- OriGene qPCR primer pairs and template standards for NUDT3
- OriGene qPCR primer pairs for NUDT3
- OriGene CRISPR knockouts for NUDT3
- OriGene ORF clones in human for NUDT3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping of latest version cDNA ORF clones for NUDT3 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for NUDT3
- GenScript Custom Assay Services for NUDT3
- GenScript Custom overexpressing Cell Line Services for NUDT3
- GenScript: Design CRISPR guide RNA sequences for NUDT3
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for NUDT3
- Sino Biological Human cDNA Clone for NUDT3
- Browse Sino Biological Cell Lysates
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- Browse Sino Biological Antibodies
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- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for NUDT3
- Novus Biologicals proteins and lysates for NUDT3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam proteins for NUDT3
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for NUDT3
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for NUDT3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for NUDT3
- VectorBuilder custom plasmid, inducible vectors for NUDT3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NUDT3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 9 available NUDT3 Antibodies ranked by validation data
- Compare Top NUDT3 Antibodies
- Quality Products:
- antibodies-online: Search results for available NUDT3 related products ranked by validation data
- antibodies-online: Search results for 11 available NUDT3 Proteins ranked by validation data
- Compare Top NUDT3 Proteins
- Quality Products:
- GeneTex NUDT3 antibody for NUDT3
- Search GeneTex for Proteins for NUDT3
- ViGene Biosciences adenoviral particle packaged cDNA for NUDT3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for NUDT3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for NUDT3 gene
- Search ViGene Biosciences for NUDT3
- Santa Cruz Biotechnology (SCBT) Antibodies for NUDT3
- Search Santa Cruz Biotechnology (SCBT) for NUDT3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for NUDT3
- Horizon Cell Lines for NUDT3
- genomics-online: cdna clones - Search results for available NUDT3 gene related products
- orf clones - Search results for available NUDT3 gene related products
- genomics-online: gRNA clones - Search results for available NUDT3 gene related products
- genomics-online: primer clones - Search results for available NUDT3 gene related products
- genomics-online: shRNA clones - Search results for available NUDT3 gene related products
Sources for NUDT3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew