Aliases for NUDT3 Gene
Aliases for NUDT3 Gene
External Ids for NUDT3 Gene
- HGNC: 8050
- Entrez Gene: 11165
- Ensembl: ENSG00000272325
- OMIM: 609228
- UniProtKB: O95989
Previous GeneCards Identifiers for NUDT3 Gene
- GC06M034258
- GC06M034302
- GC06M034363
- GC06M033978
- GC06M034388
- GC06M034894
- GC06M035232
- GC06M035727
- GC06M034550
- GC06M035568
- GC06M036281
- GC06M036655
- GC06M037008
Summaries for NUDT3 Gene
-
NUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act as homeostatic checkpoints at important stages in nucleoside phosphate metabolic pathways, guarding against elevated levels of potentially dangerous intermediates, like 8-oxo-dGTP, which promotes AT-to-CG transversions (Safrany et al., 1998 [PubMed 9822604]).[supplied by OMIM, Feb 2011]
GeneCards Summary for NUDT3 Gene
NUDT3 (Nudix Hydrolase 3) is a Protein Coding gene. Among its related pathways are Inositol phosphate metabolism (REACTOME) and Metabolism. GO annotations related to this gene include hydrolase activity and diphosphoinositol-polyphosphate diphosphatase activity. An important paralog of this gene is NUDT4.
UniProtKB/Swiss-Prot for NUDT3 Gene
-
Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphophate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT3 Gene
Genomics for NUDT3 Gene
Regulatory Elements for NUDT3 Gene
Enhancers for NUDT3 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around NUDT3 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the NUDT3 gene promoter:
Regulatory Element Products
Genomic Location for NUDT3 Gene
- Chromosome:
- 6
- Start:
- 34,279,679 bp from pter
- End:
- 34,392,680 bp from pter
- Size:
- 113,002 bases
- Orientation:
- Minus strand
Genomic View for NUDT3 Gene
Genes around NUDT3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p21.31 by Ensembl
- 6p21.31 by Entrez Gene
- 6p21.31 by HGNC
NUDT3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NUDT3 Gene
Proteins for NUDT3 Gene
-
Protein details for NUDT3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O95989-NUDT3_HUMAN
- Recommended name:
- Diphosphoinositol polyphosphate phosphohydrolase 1
- Protein Accession:
- O95989
- B2R8N4
Protein attributes for NUDT3 Gene
- Size:
- 172 amino acids
- Molecular mass:
- 19471 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Monomer.
Protein Expression for NUDT3 Gene
Post-translational modifications for NUDT3 Gene
Other Protein References for NUDT3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for NUDT3
- Novus Biologicals Antibodies for NUDT3
- Invitrogen Antibodies for NUDT3
- antibodies-online Antibodies for NUDT3: See all 9
- GeneTex NUDT3 antibody for NUDT3
-
Santa Cruz Biotechnology (SCBT) Antibodies for NUDT3
Protein Products
-
OriGene Purified Proteins for NUDT3
- Search Origene for MassSpec and Protein Over-expression Lysates for NUDT3
- Origene Custom Protein Services for NUDT3
- ProSpec Recombinant Proteins for NUDT3
- antibodies-online Proteins for NUDT3: See all 13
- Search antibodies-online for peptides
- Search GeneTex for Proteins for NUDT3
No data available for DME Specific Peptides for NUDT3 Gene
Domains & Families for NUDT3 Gene
Gene Families for NUDT3 Gene
Protein Domains for NUDT3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for NUDT3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O95989- Family:
-
- Belongs to the Nudix hydrolase family. DIPP subfamily.
Function for NUDT3 Gene
Molecular function for NUDT3 Gene
- GENATLAS Biochemistry:
- nudix (nucleoside diphosphate linked moiety X)-type motif 3,hydrolase,most predominantly expressed in brain,heart,pancreas,liver,putative mouse cleaning gene whose functions is to cleanse the cell of potentially deleterious endogenous metabolites and to modulate the accumulation of intermediates in biochemical pathways
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=5.9 uM for Ap6A {ECO:0000269 PubMed:10419486, ECO:0000269 PubMed:12370170, ECO:0000269 PubMed:9822604}; KM=7.7 uM for Ap5A {ECO:0000269 PubMed:10419486, ECO:0000269 PubMed:12370170, ECO:0000269 PubMed:9822604}; KM=38 mM for 5-phosphoribose 1-diphosphate {ECO:0000269 PubMed:10419486, ECO:0000269 PubMed:12370170, ECO:0000269 PubMed:9822604}; KM=4.2 nM for PP-InsP5 {ECO:0000269 PubMed:10419486, ECO:0000269 PubMed:12370170, ECO:0000269 PubMed:9822604}; pH dependence: Optimum pH is 7-7.5. {ECO:0000269 PubMed:10419486, ECO:0000269 PubMed:12370170, ECO:0000269 PubMed:9822604};
- UniProtKB/Swiss-Prot CatalyticActivity:
- Diphospho-myo-inositol polyphosphate + H(2)O = myo-inositol polyphosphate + phosphate.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by fluoride and InsP6.
- UniProtKB/Swiss-Prot Function:
- Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphophate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.
Enzyme Numbers (IUBMB) for NUDT3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000287 | magnesium ion binding | IDA | 19585659 |
| GO:0000298 | endopolyphosphatase activity | IBA | -- |
| GO:0008486 | diphosphoinositol-polyphosphate diphosphatase activity | IDA,TAS | 10585413 |
| GO:0016787 | hydrolase activity | IEA | -- |
| GO:0034431 | bis(5-adenosyl)-hexaphosphatase activity | IBA | -- |
Phenotypes for NUDT3 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for NUDT3
- Cyagen custom Knockout/knockin (KOKI) mouse models for NUDT3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for NUDT3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NUDT3 gene
- Search ViGene Biosciences for NUDT3
CRISPR Products
-
OriGene CRISPR knockouts for NUDT3
-
Santa Cruz Biotechnology (SCBT) CRISPR for NUDT3
- GenScript: Design CRISPR guide RNA sequences for NUDT3
miRNA for NUDT3 Gene
- miRTarBase miRNAs that target NUDT3
-
- hsa-mir-766-3p (MIRT039048)
- hsa-mir-16-5p (MIRT051285)
- hsa-mir-4753-3p (MIRT317588)
- hsa-mir-4768-5p (MIRT317589)
- hsa-mir-6809-3p (MIRT317590)
- hsa-mir-6833-3p (MIRT317591)
- hsa-mir-3941 (MIRT317605)
- hsa-mir-221-5p (MIRT317620)
- hsa-mir-8073 (MIRT317637)
- hsa-mir-617 (MIRT360631)
- hsa-mir-6505-3p (MIRT360638)
- hsa-mir-136-5p (MIRT440077)
- hsa-mir-203b-3p (MIRT443893)
- hsa-mir-7158-3p (MIRT443894)
- hsa-mir-31-5p (MIRT443895)
- hsa-mir-100-3p (MIRT443896)
- hsa-mir-526b-5p (MIRT449053)
- hsa-mir-557 (MIRT471885)
- hsa-mir-507 (MIRT471886)
- hsa-mir-7703 (MIRT471887)
- hsa-mir-4325 (MIRT471888)
- hsa-mir-4699-5p (MIRT471889)
- hsa-mir-9500 (MIRT471890)
- hsa-mir-6873-5p (MIRT471891)
- hsa-mir-5096 (MIRT522102)
- hsa-mir-5587-5p (MIRT522103)
- hsa-mir-6855-5p (MIRT522104)
- hsa-mir-3170 (MIRT522105)
- hsa-mir-197-3p (MIRT522106)
- hsa-mir-6832-5p (MIRT522107)
- hsa-mir-6801-5p (MIRT522108)
- hsa-mir-1273f (MIRT522109)
- hsa-mir-1279 (MIRT522110)
- hsa-mir-484 (MIRT522111)
- hsa-mir-3155b (MIRT522112)
- hsa-mir-3155a (MIRT522113)
- hsa-mir-6890-5p (MIRT522114)
- hsa-mir-129-5p (MIRT522115)
- hsa-mir-4282 (MIRT522116)
- hsa-mir-8055 (MIRT522117)
- hsa-mir-500b-3p (MIRT609119)
- hsa-mir-1912 (MIRT609120)
- hsa-mir-1295b-5p (MIRT609121)
- hsa-mir-603 (MIRT609122)
- hsa-mir-362-3p (MIRT609123)
- hsa-mir-329-3p (MIRT609124)
- hsa-mir-8485 (MIRT609125)
- hsa-mir-4708-5p (MIRT609126)
- hsa-mir-6088 (MIRT609127)
- hsa-mir-4770 (MIRT609128)
- hsa-mir-143-3p (MIRT609129)
- hsa-mir-5006-3p (MIRT623046)
- hsa-mir-4755-5p (MIRT623047)
- hsa-mir-5089-5p (MIRT623048)
- hsa-mir-211-5p (MIRT623049)
- hsa-mir-204-5p (MIRT623050)
- hsa-mir-623 (MIRT623051)
- hsa-mir-6832-3p (MIRT623052)
- hsa-mir-3938 (MIRT623053)
- hsa-mir-493-5p (MIRT630981)
- hsa-mir-6878-3p (MIRT639030)
- hsa-mir-7973 (MIRT639031)
- hsa-mir-6744-3p (MIRT639032)
- hsa-mir-4757-5p (MIRT639033)
- hsa-mir-7114-3p (MIRT639034)
- hsa-mir-1180-5p (MIRT639035)
- hsa-mir-3922-3p (MIRT639036)
- hsa-mir-3176 (MIRT639037)
- hsa-mir-372-5p (MIRT639038)
- hsa-mir-371a-5p (MIRT639039)
- hsa-mir-616-5p (MIRT639040)
- hsa-mir-373-5p (MIRT639041)
- hsa-mir-371b-5p (MIRT639042)
- hsa-mir-6747-3p (MIRT639043)
- hsa-mir-1224-3p (MIRT639044)
- hsa-mir-6513-3p (MIRT639045)
- hsa-mir-1253 (MIRT655688)
- hsa-mir-6794-3p (MIRT655689)
- hsa-mir-4653-3p (MIRT655690)
- hsa-mir-8082 (MIRT655691)
- hsa-mir-4534 (MIRT655692)
- hsa-mir-4639-3p (MIRT655693)
- hsa-mir-6514-5p (MIRT655694)
- hsa-mir-6734-3p (MIRT667127)
- hsa-mir-9-3p (MIRT667128)
- hsa-mir-4524a-3p (MIRT667129)
- hsa-mir-302a-5p (MIRT667130)
- hsa-mir-6758-3p (MIRT667131)
- hsa-mir-4797-5p (MIRT667132)
- hsa-mir-4422 (MIRT667133)
- hsa-mir-4312 (MIRT701290)
- hsa-mir-6778-3p (MIRT701291)
- hsa-mir-150-5p (MIRT701292)
- hsa-mir-212-5p (MIRT701293)
- hsa-mir-186-3p (MIRT701294)
- hsa-mir-520h (MIRT701295)
- hsa-mir-520g-3p (MIRT701296)
- hsa-mir-512-3p (MIRT701297)
- hsa-mir-520e (MIRT701298)
- hsa-mir-520d-3p (MIRT701299)
- hsa-mir-520c-3p (MIRT701300)
- hsa-mir-520b (MIRT701301)
- hsa-mir-520a-3p (MIRT701302)
- hsa-mir-373-3p (MIRT701303)
- hsa-mir-372-3p (MIRT701304)
- hsa-mir-302e (MIRT701305)
- hsa-mir-302d-3p (MIRT701306)
- hsa-mir-302c-3p (MIRT701307)
- hsa-mir-302b-3p (MIRT701308)
- hsa-mir-302a-3p (MIRT701309)
- hsa-mir-93-5p (MIRT701310)
- hsa-mir-526b-3p (MIRT701311)
- hsa-mir-519d-3p (MIRT701312)
- hsa-mir-20b-5p (MIRT701313)
- hsa-mir-20a-5p (MIRT701314)
- hsa-mir-17-5p (MIRT701315)
- hsa-mir-106b-5p (MIRT701316)
- hsa-mir-106a-5p (MIRT701317)
- hsa-mir-4659b-3p (MIRT720369)
- hsa-mir-4659a-3p (MIRT720370)
- hsa-mir-6875-3p (MIRT720371)
- hsa-mir-4291 (MIRT720372)
- hsa-mir-7157-5p (MIRT720373)
- hsa-mir-4310 (MIRT720374)
- hsa-mir-1179 (MIRT720375)
- hsa-mir-6835-3p (MIRT720376)
- hsa-mir-548e-5p (MIRT720377)
miRNA Products
- Search ViGene Biosciences for NUDT3
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for NUDT3
- Browse OriGene Inhibitory RNA Products For NUDT3
-
ViGene Biosciences ready-to-package AAV shRNAs for NUDT3 gene
Clone Products
-
OriGene ORF clones in human for NUDT3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for NUDT3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for NUDT3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NUDT3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for NUDT3
-
ViGene Biosciences adenoviral particle packaged cDNA for NUDT3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for NUDT3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NUDT3 gene
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUDT3 Gene
Localization for NUDT3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NUDT3 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 4 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | -- |
| GO:0005737 | cytoplasm | IEA,IBA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0070062 | extracellular exosome | IDA | 23376485 |
Pathways & Interactions for NUDT3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Inositol phosphate metabolism (REACTOME) | ||
| 2 | Metabolism |
.37
|
|
Pathways by source for NUDT3 Gene
3 Reactome pathways for NUDT3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007267 | cell-cell signaling | TAS | 10419486 |
| GO:0015961 | diadenosine polyphosphate catabolic process | TAS | 10419486 |
| GO:0043647 | inositol phosphate metabolic process | TAS | -- |
| GO:0071544 | diphosphoinositol polyphosphate catabolic process | IDA | 10585413 |
| GO:1901907 | diadenosine pentaphosphate catabolic process | IBA | -- |
No data available for SIGNOR curated interactions for NUDT3 Gene
Drugs & Compounds for NUDT3 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 5-Diphosphoinositol pentakisphosphate |
|
|
|
|||
| Diadenosine hexaphosphate |
|
56983-23-4 |
|
|||
| Myo-inositol hexakisphosphate |
|
83-86-3 |
|
|||
| Phosphate |
|
14265-44-2 |
|
Transcripts for NUDT3 Gene
mRNA/cDNA for NUDT3 Gene
- (1) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (1683) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for NUDT3 Gene
- Nudix (nucleoside diphosphate linked moiety X)-type motif 3:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for NUDT3
-
Santa Cruz Biotechnology (SCBT) CRISPR for NUDT3
- GenScript: Design CRISPR guide RNA sequences for NUDT3
miRNA Products
- Search ViGene Biosciences for NUDT3
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for NUDT3
- Browse OriGene Inhibitory RNA Products For NUDT3
-
ViGene Biosciences ready-to-package AAV shRNAs for NUDT3 gene
Clone Products
-
OriGene ORF clones in human for NUDT3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for NUDT3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for NUDT3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NUDT3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for NUDT3 Gene
This gene is overexpressed in Peripheral blood mononuclear cells (11.6) and Fetal Brain (6.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NUDT3 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of NUDT3 Gene:
NUDT3SOURCE GeneReport for Unigene cluster for NUDT3 Gene:
Hs.188882mRNA Expression by UniProt/SwissProt for NUDT3 Gene:
O95989-NUDT3_HUMAN
Tissue specificity:
Widely expressed. Expressed at higher level in brain, heart, pancreas and liver. Also expressed in placenta, lung and kidney.
Evidence on tissue expression from TISSUES for NUDT3 Gene
- Nervous system(4.8)
- Lung(3.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for NUDT3
-
OriGene qPCR primer pairs for NUDT3
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUDT3 Gene
Orthologs for NUDT3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | RPS10 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | NUDT3 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | NUDT3 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | NUDT3 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | NUDT3 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Nudt3 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Nudt3 34 |
|
||
| chicken (Gallus gallus) |
Aves | NUDT3 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | NUDT3 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | nudt3a 35 |
|
OneToMany | |
| nudt3b 34 35 |
|
||||
| zgc55746 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.7396 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG6391 36 |
|
|
|
| Aps 34 35 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009901 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | Y92H12BL.5 34 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.8787 35 |
|
OneToMany |
- Species where no ortholog for NUDT3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for NUDT3 Gene
Variants for NUDT3 Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000010018 | -- | 34,329,049(+) | CTGGT(A/G)ACAAT | intron-variant | |
| rs1000045434 | -- | 34,388,209(+) | ATTCT(A/G)TGATG | intron-variant | |
| rs1000059920 | -- | 34,368,519(+) | AAAAC(A/G/T)TAGTA | intron-variant | |
| rs1000096375 | -- | 34,341,028(+) | AATCA(A/G)TCTTA | intron-variant | |
| rs1000097815 | -- | 34,294,657(+) | GGAGG(C/T)GGAGG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv10618n54 | CNV | loss | 21841781 |
| dgv10619n54 | CNV | loss | 21841781 |
| dgv10620n54 | CNV | loss | 21841781 |
| dgv10621n54 | CNV | loss | 21841781 |
| dgv10622n54 | CNV | loss | 21841781 |
| dgv10623n54 | CNV | loss | 21841781 |
| dgv1115e199 | CNV | deletion | 23128226 |
| esv2674771 | CNV | deletion | 23128226 |
| esv2731907 | CNV | deletion | 23290073 |
| esv29044 | CNV | loss | 19812545 |
| esv33496 | CNV | loss | 17666407 |
| esv3425871 | CNV | insertion | 20981092 |
| esv3567619 | CNV | deletion | 23714750 |
| esv3608655 | CNV | loss | 21293372 |
| esv3608656 | CNV | loss | 21293372 |
| esv3608657 | CNV | loss | 21293372 |
| nsv1034978 | CNV | gain | 25217958 |
| nsv473801 | CNV | novel sequence insertion | 20440878 |
| nsv5253 | CNV | insertion | 18451855 |
| nsv602863 | CNV | loss | 21841781 |
| nsv602886 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
46.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.67;
14.27% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for NUDT3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- NUDT3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT3 Gene
Disorders for NUDT3 Gene
Relevant External Links for NUDT3
No disorders were found for NUDT3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUDT3 Gene
Publications for NUDT3 Gene
- A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase. (PMID: 9822604) Safrany S.T. … Shears S.B. (EMBO J. 1998) 2 3 4 22 64
- Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate. (PMID: 12370170) Fisher D.I. … Cartwright J.L. (J. Biol. Chem. 2002) 3 4 22 64
- The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein. (PMID: 10419486) Safrany S.T. … Shears S.B. (J. Biol. Chem. 1999) 3 4 22 64
- Identification of 15 loci influencing height in a Korean population. (PMID: 19893584) Kim J.J. … Lee J.K. (J. Hum. Genet. 2010) 3 46 64
- Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PMID: 20935630) Speliotes E.K. … Loos R.J. (Nat. Genet. 2010) 3 46 64
Products for NUDT3 Gene
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- Custom Antibody ServicesOriGene Antibodies for NUDT3
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- OriGene Purified Proteins for NUDT3
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- OriGene qPCR primer pairs for NUDT3
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA ORF clone for NUDT3 in any vector
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- Novus Biologicals Antibodies for NUDT3
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- Taconic Biosciences Mouse Models for NUDT3
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- Humanized Mice
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- antibodies-online Antibodies for NUDT3: See all 9
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- antibodies-online Proteins for NUDT3: See all 13
- Search antibodies-online for peptides
- GeneTex NUDT3 antibody for NUDT3
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- ViGene Biosciences adenoviral particle packaged cDNA for NUDT3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for NUDT3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for NUDT3 gene
- Search ViGene Biosciences for NUDT3
- Santa Cruz Biotechnology (SCBT) Antibodies for NUDT3
- Search Santa Cruz Biotechnology (SCBT) for NUDT3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for NUDT3
- Horizon Cell Lines for NUDT3
- Cyagen custom Knockout/knockin (KOKI) mouse models for NUDT3
- VectorBuilder custom plasmid, inducible vectors for NUDT3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NUDT3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for NUDT3 Gene
- (1) GeneCards
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- (32) CGAP SAGE
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- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
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- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
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- (55) HORDE
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- (59) MILLIPORE
- (60) miRBase
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- (62) NCBI
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- (64) PubMed
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- (66) TGDB
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- (68) Abcam
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- (71) Sino Biological
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- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
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- (84) DISEASES
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- (100) COMPARTMENTS
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- (104) Addgene
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- (155) Gene ORGANizer