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NUDT3 Gene

protein-coding   GIFtS: 55
GCID: GC06M035727

Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif...

  Search for NUDT3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 31 2     DIPP-12 3
Diadenosine 5',5'''-P1,P6-Hexaphosphate Hydrolase 12 3     DIPP12 3
Nucleoside Diphosphate-Linked Moiety X Motif 32 3     Diphosphoinositol Polyphosphate Phosphohydrolase 12
Nudix Motif 32 3     EC 3.6.1.-3
DIPP2 3     EC 3.6.1.523

External Ids:    HGNC: 80501   Entrez Gene: 111652   Ensembl: ENSG000002723257   OMIM: 6092285   UniProtKB: O959893   

Export aliases for NUDT3 gene to outside databases

Previous GC identifers: GC06M034258 GC06M034302 GC06M034363 GC06M033978 GC06M034388 GC06M034894 GC06M035232


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NUDT3 Gene:
NUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act as homeostatic checkpoints at important
stages in nucleoside phosphate metabolic pathways, guarding against elevated levels of potentially dangerous
intermediates, like 8-oxo-dGTP, which promotes AT-to-CG transversions (Safrany et al., 1998 (PubMed
9822604)).(supplied by OMIM, Feb 2011)

GeneCards Summary for NUDT3 Gene:
NUDT3 (nudix (nucleoside diphosphate linked moiety X)-type motif 3) is a protein-coding gene. GO annotations related to this gene include inositol diphosphate tetrakisphosphate diphosphatase activity and magnesium ion binding. An important paralog of this gene is NUDT4.

UniProtKB/Swiss-Prot: NUDT3_HUMAN, O95989
Function: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate)
and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal
transduction. InsP6 (inositol hexakisphophate) is not a substrate. Acts as a negative regulator of the ERK1/2
pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the
preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able
to hydrolyze 5-phosphoribose 1-diphosphate

Gene Wiki entry for NUDT3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the NUDT3 gene promoter:
         STAT5B   NF-1/L   AML1a   FOXD3   E47   C/EBPalpha   Hand1   Chx10   SEF-1 (1)   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNUDT3 promoter sequence
   Search Chromatin IP Primers for NUDT3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NUDT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.2   Ensembl cytogenetic band:  6p21.31   HGNC cytogenetic band: 6p21.2

NUDT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUDT3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M035727:  view genomic region     (about GC identifiers)

Start:
34,247,456 bp from pter      End:
34,360,457 bp from pter
Size:
113,002 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NUDT3_HUMAN, O95989 (See protein sequence)
Recommended Name: Diphosphoinositol polyphosphate phosphohydrolase 1  
Size: 172 amino acids; 19471 Da
Cofactor: Binds 3 magnesium ions per subunit
Subunit: Monomer (By similarity)
2 PDB 3D structures from and Proteopedia for NUDT3:
2FVV (3D)        2Q9P (3D)    
Secondary accessions: B2R8N4

Explore the universe of human proteins at neXtProt for NUDT3: NX_O95989

Explore proteomics data for NUDT3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NUDT3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006694.1  
    ENSEMBL proteins: 
     ENSP00000476119  
    Reactome Protein details: O95989

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NUDT: Nudix motif containing

    3 InterPro protein domains:
     IPR015797 NUDIX_hydrolase_dom-like
     IPR020084 NUDIX_hydrolase_CS
     IPR000086 NUDIX_hydrolase_dom

    Graphical View of Domain Structure for InterPro Entry O95989

    ProtoNet protein and cluster: O95989

    1 Blocks protein domain: IPB000086 NUDIX hydrolase

    UniProtKB/Swiss-Prot: NUDT3_HUMAN, O95989
    Similarity: Belongs to the Nudix hydrolase family. DIPP subfamily
    Similarity: Contains 1 nudix hydrolase domain


    Find genes that share domains with NUDT3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NUDT3_HUMAN, O95989
    Function: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate)
    and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal
    transduction. InsP6 (inositol hexakisphophate) is not a substrate. Acts as a negative regulator of the ERK1/2
    pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the
    preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able
    to hydrolyze 5-phosphoribose 1-diphosphate
    Catalytic activity: Diphospho-myo-inositol polyphosphate + H(2)O = myo-inositol polyphosphate + phosphate
    Enzyme regulation: Inhibited by fluoride and InsP6
    Biophysicochemical properties: Kinetic parameters: KM=5.9 uM for Ap6A; KM=7.7 uM for Ap5A; KM=38 mM for
    5-phosphoribose 1-diphosphate; KM=4.2 nM for PP-InsP5; pH dependence: Optimum pH is 7-7.5;

         Genatlas biochemistry entry for NUDT3:
    nudix (nucleoside diphosphate linked moiety X)-type motif 3,hydrolase,most predominantly expressed in
    brain,heart,pancreas,liver,putative mouse cleaning gene whose functions is to cleanse the cell of potentially
    deleterious endogenous metabolites and to modulate the accumulation of intermediates in biochemical pathways

         Enzyme Numbers (IUBMB): EC 3.6.1.521 EC 3.6.1.-1

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA19585659
    GO:0008486diphosphoinositol-polyphosphate diphosphatase activity IDA10585413
    GO:0016787hydrolase activity ----
    GO:0052840inositol diphosphate tetrakisphosphate diphosphatase activity IEA--
    GO:0052843inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity IEA--
         
    Find genes that share ontologies with NUDT3           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for NUDT3:
     Decreased Hepatitis C virus re  Decreased TP53 protein express  Synthetic lethal with imatinib 

    Animal Models:
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    Selected qRT-PCR Assays for microRNAs that regulate NUDT3 (see all 25):
    hsa-miR-21* hsa-miR-3910 hsa-miR-520d-5p hsa-miR-410 hsa-miR-583 hsa-miR-124 hsa-miR-532-5p hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidNUDT3 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NUDT3_HUMAN, O95989: Cytoplasm (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    Find genes that share ontologies with NUDT3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NUDT3 About    
    See pathways by source

    SuperPathContained pathways About
    1Inositol phosphate metabolism (REACTOME)
    Inositol phosphate metabolism0.59
    Synthesis of pyrophosphates in the cytosol0.00
    2Metabolism
    Metabolism0.38


    Find genes that share SuperPaths with NUDT3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for NUDT3
        Synthesis of pyrophosphates in the cytosol


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NUDT3
    Interactions:

        Search GeneGlobe Interaction Network for NUDT3

    Selected Interacting proteins for NUDT3 (O959892, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDR1Q083452, 3MINT-8264722 I2D: score=2 
    ENSG00000137332Q083452, 3MINT-8264722 I2D: score=2 
    ENSG00000215522Q083452, 3MINT-8264722 I2D: score=2 
    ENSG00000230456Q083452, 3MINT-8264722 I2D: score=2 
    ENSG00000234078Q083452, 3MINT-8264722 I2D: score=2 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007267cell-cell signaling TAS10419486
    GO:0015961diadenosine polyphosphate catabolic process TAS10419486
    GO:0043647inositol phosphate metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0071544diphosphoinositol polyphosphate catabolic process IDA10585413

    Find genes that share ontologies with NUDT3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NUDT3

    6 HMDB Compounds for NUDT3    About this table
    CompoundSynonyms CAS #PubMed Ids
    5-Diphosphoinositol pentakisphosphate5-diphospho-1D-myo-inositol pentakisphosphate (see all 11)----
    Diadenosine hexaphosphateAdenosine 5'-(heptahydrogen hexaphosphate) P->5'-ester with adenosine (see all 9)56983-23-4--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Myo-inositol hexakisphosphate1D-myo-Inositol 1,2,3,4,5,6-hexakisphosphate (see all 9)83-86-3--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    4 Novoseek inferred chemical compound relationships for NUDT3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ap(6)a 93.8 1 10419486 (1)
    dipp 91.4 7 9822604 (3), 12370170 (2)
    prpp 76.3 4 12370170 (2)
    pyrophosphate 57.4 3 9822604 (1), 15212765 (1)



    Find genes that share compounds with NUDT3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NUDT3 gene: 
    NM_006703.3  

    Unigene Cluster for NUDT3:

    Nudix (nucleoside diphosphate linked moiety X)-type motif 3
    Hs.188882  [show with all ESTs]
    Unigene Representative Sequence: NM_001202470
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000607016
    miRNA
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    hsa-miR-21* hsa-miR-3910 hsa-miR-520d-5p hsa-miR-410 hsa-miR-583 hsa-miR-124 hsa-miR-532-5p hsa-miR-23a
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    Additional mRNA sequence: 

    AF062529.1 AF062530.1 AK124804.1 AK313440.1 BC007727.2 BT019984.1 BT019985.1 

    Selected DOTS entries (see all 27):

    DT.100816157  DT.318336  DT.100646332  DT.91865700  DT.99960049  DT.121358641  DT.121358935  DT.100816158 
    DT.95339214  DT.318334  DT.121359042  DT.40219001  DT.100741966  DT.121359032  DT.97804088  DT.100741970 
    DT.100742004  DT.100816155  DT.100851413  DT.102845466  DT.120731171  DT.121358763  DT.87009604  DT.91780069 

    4 AceView cDNA sequences:

    BC024593 AW875186 BE888564 BF805177 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NUDT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCTGTCCCT
    NUDT3 Expression
    About this image

    NUDT3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NUDT3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.188882

    UniProtKB/Swiss-Prot: NUDT3_HUMAN, O95989
    Tissue specificity: Widely expressed. Expressed at higher level in brain, heart, pancreas and liver. Also
    expressed in placenta, lung and kidney

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NUDT3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nudt31 , 5 nudix (nucleotide diphosphate linked moiety X)-type more1, 5 91.07(n)1
    97.62(a)1
      17 (14.59 cM)5
    564091  NM_019837.21  NP_062811.11 
     275793825 
    chicken
    (Gallus gallus)
    Aves NUDT31 nudix (nucleoside diphosphate linked moiety X)-type more 85.8(n)
    93.49(a)
      419905  NM_001257298.1  NP_001244227.1 
    lizard
    (Anolis carolinensis)
    Reptilia NUDT36
    nudix (nucleoside diphosphate linked moiety X)-typ...
    91(a)
    1 ↔ 1
    4(121456909-121489247)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc557462 similar to nudix (nucleotide diphosphate linked moiety more 80.47(n)   394120  BC048064.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG63913
    Aps1
    diphosphoinositol-polyphosphate
    diphosphatase3
    Aps1
    57(a)3
    56.04(n)1
    57.5(a)1
      67F33
    392261  NM_140164.31  NP_648421.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y92H12BL.51 Y92H12BL.5 49.48(n)
    43.75(a)
      259365  NM_170801.5  NP_740784.1 


    ENSEMBL Gene Tree for NUDT3 (if available)
    TreeFam Gene Tree for NUDT3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NUDT3 gene
    NUDT42  NUDT112  NUDT102  
    4 SIMAP similar genes for NUDT3 using alignment to 1 protein entry:     NUDT3_HUMAN:
    NUDT4    NUDT10    NUDT11    RPS10-NUDT3

    Find genes that share paralogs with NUDT3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for NUDT3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2674771CNV Deletion23128226
    esv2731907CNV Deletion23290073
    dgv1115e199CNV Deletion23128226
    nsv5253CNV Insertion18451855
    esv29044CNV Loss19812545
    esv33496CNV Loss17666407

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609228    OMIM disorders: --


    Find genes that share disorders with NUDT3           About GenesLikeMe

    Genetic Association Database (GAD): NUDT3

    Export disorders for NUDT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NUDT3 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with NUDT3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase. (PubMed id 9822604)1, 2, 3, 9 Safrany S.T.... Shears S.B. (EMBO J. 1998)
    2. Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate. (PubMed id 12370170)1, 2, 9 Fisher D.I.... Cartwright J.L. (J. Biol. Chem. 2002)
    3. The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein. (PubMed id 10419486)1, 2, 9 Safrany S.T.... Shears S.B. (J. Biol. Chem. 1999)
    4. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PubMed id 20935630)1, 4 Speliotes E.K....Loos R.J. (Nat. Genet. 2010)
    5. Identification of 15 loci influencing height in a Korean population. (PubMed id 19893584)1, 4 Kim J.J....Lee J.K. (J. Hum. Genet. 2010)
    6. Crystal structure of human diphosphoinositol phosphatase 1. (PubMed id 19585659)1, 2 Thorsell A.G....Hallberg B.M. (Proteins 2009)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    9. Site-directed mutagenesis of diphosphoinositol polyphosphate phosphohydrolase, a dual specificity NUDT enzyme that attacks diadenosine polyphosphates and diphosphoinositol polyphosphates. (PubMed id 10585413)1, 2 Yang X.... Shears S.B. (J. Biol. Chem. 1999)
    10. NUDT3 rs206936 is associated with body mass index in obese Japanese women. (PubMed id 23708086)1 Kitamoto A....Hotta K. (Endocr. J. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11165 HGNC: 8050 AceView: NUDT3.1 Ensembl:ENSG00000272325 euGenes: HUgn11165
    ECgene: NUDT3 H-InvDB: NUDT3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NUDT3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NUDT3 gene:
    Search GeneIP for patents involving NUDT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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