Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NUDT3 Gene

protein-coding   GIFtS: 54
GCID: GC06M035232

Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif...
  Search for NUDT3
at
MalaCards
 

Aliases
for NUDT3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 31 2     DIPP-12 3
Diadenosine 5',5'''-P1,P6-Hexaphosphate Hydrolase 12 3     DIPP12 3
Nucleoside Diphosphate-Linked Moiety X Motif 32 3     Diphosphoinositol Polyphosphate Phosphohydrolase 12
Nudix Motif 32 3     EC 3.6.1.-3
DIPP2 3     EC 3.6.1.523

External Ids:    HGNC: 80501   Entrez Gene: 111652   Ensembl: ENSG000002723257   OMIM: 6092285   UniProtKB: O959893   

Export aliases for NUDT3 gene to outside databases

Previous GC identifers: GC06M034258 GC06M034302 GC06M034363 GC06M033978 GC06M034388 GC06M034894


Summaries
for NUDT3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NUDT3 Gene:
NUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act as homeostatic checkpoints at important
stages in nucleoside phosphate metabolic pathways, guarding against elevated levels of potentially dangerous
intermediates, like 8-oxo-dGTP, which promotes AT-to-CG transversions (Safrany et al., 1998 (PubMed
9822604)).(supplied by OMIM, Feb 2011)

GeneCards Summary for NUDT3 Gene: 
NUDT3 (nudix (nucleoside diphosphate linked moiety X)-type motif 3) is a protein-coding gene. Among its related super-pathways are Synthesis of IP3 and IP4 in the cytosol and inositol pyrophosphates biosynthesis. GO annotations related to this gene include inositol diphosphate tetrakisphosphate diphosphatase activity and magnesium ion binding. An important paralog of this gene is NUDT4.

UniProtKB/Swiss-Prot: NUDT3_HUMAN, O95989
Function: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate)
and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal
transduction. InsP6 (inositol hexakisphophate) is not a substrate. Acts as a negative regulator of the ERK1/2
pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the
preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able
to hydrolyze 5-phosphoribose 1-diphosphate

Gene Wiki entry for NUDT3 Gene


Genomic Views
for NUDT3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NUDT3 gene promoter:
         STAT5B   NF-1/L   AML1a   FOXD3   E47   C/EBPalpha   Hand1   Chx10   SEF-1 (1)   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NUDT3 promoter sequence
   Search SABiosciences Chromatin IP Primers for NUDT3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUDT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.2   Ensembl cytogenetic band:  6p21.31   HGNC cytogenetic band: 6p21.2

NUDT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUDT3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M035232:  view genomic region     (about GC identifiers)

Start:
 34,247,456 bp from pter      End:
 34,360,457 bp from pter
Size:
 113,002 bases      Orientation:
 minus strand

Proteins
for NUDT3 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: NUDT3_HUMAN, O95989 (See protein sequence)
Recommended Name: Diphosphoinositol polyphosphate phosphohydrolase 1  
Size: 172 amino acids; 19471 Da
Cofactor: Binds 3 magnesium ions per subunit
Subunit: Monomer (By similarity)
Subcellular location: Cytoplasm (Probable)
2 PDB 3D structures from and Proteopedia for NUDT3:
2FVV (3D)        2Q9P (3D)    
Secondary accessions: B2R8N4

Explore the universe of human proteins at neXtProt for NUDT3: NX_O95989

Explore proteomics data for NUDT3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95989

    • NUDT3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NUDT3 Protein Expression
    REFSEQ proteins: NP_006694.1  
    ENSEMBL proteins: 
     ENSP00000476119  
    Reactome Protein details: O95989
    Human Recombinant Protein Products for NUDT3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for NUDT3
    GenScript Custom Purified and Recombinant Proteins Services for NUDT3
    Novus Biologicals NUDT3 Proteins
    Novus Biologicals NUDT3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for NUDT3
    Cloud-Clone Corp. Proteins for NUDT3 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    NUDT3 for ontologies           About GeneDecksing



    NUDT3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NUDT3
    GenScript Custom Superior Antibodies Services for NUDT3
    Novus Biologicals NUDT3 Antibodies
    Abcam antibodies for NUDT3
    Cloud-Clone Corp. Antibodies for NUDT3 
    ThermoFisher Antibodies for NUDT3
    LSBio Antibodies in human, mouse, rat for NUDT3 

    Assay Products for NUDT3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NUDT3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NUDT3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NUDT3 
    Cloud-Clone Corp. CLIAs for NUDT3

    Protein Domains /
    Families
    for NUDT3 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    NUDT: Nudix motif containing

    3 InterPro protein domains:
     IPR015797 NUDIX_hydrolase_dom-like
     IPR020084 NUDIX_hydrolase_CS
     IPR000086 NUDIX_hydrolase_dom

    Graphical View of Domain Structure for InterPro Entry O95989

    ProtoNet protein and cluster: O95989

    1 Blocks protein domain: IPB000086 NUDIX hydrolase

    UniProtKB/Swiss-Prot: NUDT3_HUMAN, O95989
    Similarity: Belongs to the Nudix hydrolase family. DIPP subfamily
    Similarity: Contains 1 nudix hydrolase domain


    NUDT3 for domains           About GeneDecksing


    Function
    for NUDT3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NUDT3_HUMAN, O95989
    Function: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate)
    and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal
    transduction. InsP6 (inositol hexakisphophate) is not a substrate. Acts as a negative regulator of the ERK1/2
    pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the
    preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able
    to hydrolyze 5-phosphoribose 1-diphosphate
    Catalytic activity: Diphospho-myo-inositol polyphosphate + H(2)O = myo-inositol polyphosphate + phosphate
    Enzyme regulation: Inhibited by fluoride and InsP6
    Biophysicochemical properties: Kinetic parameters: KM=5.9 uM for Ap6A; KM=7.7 uM for Ap5A; KM=38 mM for
    5-phosphoribose 1-diphosphate; KM=4.2 nM for PP-InsP5; pH dependence: Optimum pH is 7-7.5;

         Genatlas biochemistry entry for NUDT3:
    nudix (nucleoside diphosphate linked moiety X)-type motif 3,hydrolase,most predominantly expressed in
    brain,heart,pancreas,liver,putative mouse cleaning gene whose functions is to cleanse the cell of potentially
    deleterious endogenous metabolites and to modulate the accumulation of intermediates in biochemical pathways

         Enzyme Numbers (IUBMB): EC 3.6.1.521 EC 3.6.1.-1

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA19585659
    GO:0008486diphosphoinositol-polyphosphate diphosphatase activity IDA10585413
    GO:0016787hydrolase activity ----
    GO:0052840inositol diphosphate tetrakisphosphate diphosphatase activity IEA--
    GO:0052843inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity IEA--
         
    NUDT3 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for NUDT3:
     Decreased Hepatitis C virus re  Decreased TP53 protein express  Synthetic lethal with imatinib 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NUDT3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NUDT3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NUDT3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NUDT3 

    miRNA
    Products:            		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NUDT3
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate NUDT3 (see all 25):
    hsa-miR-21* hsa-miR-3910 hsa-miR-520d-5p hsa-miR-410 hsa-miR-583 hsa-miR-124 hsa-miR-532-5p hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmid: NUDT3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NUDT3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUDT3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NUDT3
    Sirion Biotech Customized adenovirus for overexpression of NUDT3

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NUDT3 (see all 7)
    OriGene ORF clones in mouse, rat for NUDT3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NUDT3 (NM_006703)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUDT3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUDT3
    Sirion Biotech Customized lentivirus for stable overexpression of NUDT3 
                         Customized lentivirus expression plasmids for stable overexpression of NUDT3 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for NUDT3
    Search LifeMap BioReagents cell lines for NUDT3
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT3


    Pathways & Interactions
    for NUDT3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NUDT3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Synthesis of IP3 and IP4 in the cytosol
    		Inositol phosphate metabolism0.57
    2inositol pyrophosphates biosynthesis
    		Synthesis of pyrophosphates in the cytosol0.42
    3Metabolism
    		Metabolism0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3        Reactome Pathways for NUDT3
        Metabolism
    Synthesis of pyrophosphates in the cytosol
    Inositol phosphate metabolism



    NUDT3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NUDT3

    5/41 Interacting proteins for NUDT3 (O959892, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDR1Q083452, 3MINT-8264722 I2D: score=2 
    ENSG00000137332Q083452, 3MINT-8264722 I2D: score=2 
    ENSG00000215522Q083452, 3MINT-8264722 I2D: score=2 
    ENSG00000230456Q083452, 3MINT-8264722 I2D: score=2 
    ENSG00000234078Q083452, 3MINT-8264722 I2D: score=2 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007267cell-cell signaling TAS10419486
    GO:0015961diadenosine polyphosphate catabolic process TAS10419486
    GO:0043647inositol phosphate metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0071544diphosphoinositol polyphosphate catabolic process IDA10585413

    NUDT3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NUDT3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NUDT3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NUDT3

    6 HMDB Compounds for NUDT3    About this table
    CompoundSynonyms CAS #PubMed Ids
    5-Diphosphoinositol pentakisphosphate5-diphospho-1D-myo-inositol pentakisphosphate (see all 11)----
    Diadenosine hexaphosphateAdenosine 5'-(heptahydrogen hexaphosphate) P->5'-ester with adenosine (see all 9)56983-23-4--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Myo-inositol hexakisphosphate1D-myo-Inositol 1,2,3,4,5,6-hexakisphosphate (see all 9)83-86-3--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    4 Novoseek inferred chemical compound relationships for NUDT3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ap(6)a 93.8 1 10419486 (1)
    dipp 91.4 7 9822604 (3), 12370170 (2)
    prpp 76.3 4 12370170 (2)
    pyrophosphate 57.4 3 9822604 (1), 15212765 (1)

    Search CenterWatch for drugs/clinical trials and news about NUDT3

    Transcripts
    for NUDT3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NUDT3 gene: 
    NM_006703.3  

    Unigene Cluster for NUDT3:

    Nudix (nucleoside diphosphate linked moiety X)-type motif 3
    Hs.188882  [show with all ESTs]
    Unigene Representative Sequence: NM_001202470
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000607016
    miRNA
    Products:             		 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NUDT3
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate NUDT3 (see all 25):
    hsa-miR-21* hsa-miR-3910 hsa-miR-520d-5p hsa-miR-410 hsa-miR-583 hsa-miR-124 hsa-miR-532-5p hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmid: NUDT3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NUDT3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUDT3
    Clone
    Products:             		 OriGene clones in human, mouse for NUDT3 (see all 7)
    OriGene ORF clones in mouse, rat for NUDT3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NUDT3 (NM_006703)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUDT3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUDT3
    Sirion Biotech Customized lentivirus for stable overexpression of NUDT3 
                         Customized lentivirus expression plasmids for stable overexpression of NUDT3 
    Primer
    Products:            		OriGene qPCR primer pairs and template standards for NUDT3
    OriGene qSTAR qPCR primer pairs in human, mouse for NUDT3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NUDT3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUDT3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUDT3

    Additional mRNA sequence: 

    AF062529.1 AF062530.1 AK124804.1 AK313440.1 BC007727.2 BT019984.1 BT019985.1 

    24/27 DOTS entries (see all 27):

    DT.100816157  DT.318336  DT.100646332  DT.91865700  DT.99960049  DT.121358641  DT.121358935  DT.100816158 
    DT.95339214  DT.318334  DT.121359042  DT.40219001  DT.100741966  DT.121359032  DT.97804088  DT.100741970 
    DT.100742004  DT.100816155  DT.100851413  DT.102845466  DT.120731171  DT.121358763  DT.87009604  DT.91780069 

    4 AceView cDNA sequences:

    BE888564 BC024593 AW875186 BF805177 

    GeneLoc Exon Structure


    Expression
    for NUDT3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NUDT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCTGTCCCT
    NUDT3 Expression
    About this image


    See NUDT3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NUDT3

    SOURCE GeneReport for Unigene cluster: Hs.188882

    UniProtKB/Swiss-Prot: NUDT3_HUMAN, O95989
    Tissue specificity: Widely expressed. Expressed at higher level in brain, heart, pancreas and liver. Also
    expressed in placenta, lung and kidney

        SABiosciences Custom PCR Arrays for NUDT3
    Primer
    Products:    		OriGene qPCR primer pairs and template standards for NUDT3
    OriGene qSTAR qPCR primer pairs in human, mouse for NUDT3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NUDT3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUDT3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUDT3
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT3

    Orthologs
    for NUDT3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for NUDT3 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Nudt31 , 5 nudix (nucleotide diphosphate linked moiety X)-type more1, 5 91.07(n)1
    97.62(a)1    		   17 (14.59 cM)5
    564091  NM_019837.21  NP_062811.11 
     275793825 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc557462 similar to nudix (nucleotide diphosphate linked moiety more 80.47(n)   394120  BC048064.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y92H12BL.51 Protein Y92H12BL.5 49.47(n)
    44.44(a)    		   259365  NM_170801.4  NP_740784.1 


    ENSEMBL Gene Tree for NUDT3 (if available)
    TreeFam Gene Tree for NUDT3 (if available)

    Paralogs
    for NUDT3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NUDT3 gene
    NUDT42  NUDT112  NUDT102  
    3 SIMAP similar genes for NUDT3 using alignment to 1 protein entry:     NUDT3_HUMAN:
    NUDT4    NUDT10    NUDT11

    NUDT3 for paralogs           About GeneDecksing



    Genomic Variants
    for NUDT3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    		Structural Variations
         Database of Genomic Variants (DGV) 6 variations for NUDT3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2674771CNV Deletion23128226
    esv2731907CNV Deletion23290073
    dgv1115e199CNV Deletion23128226
    nsv5253CNV Insertion18451855
    esv29044CNV Loss19812545
    esv33496CNV Loss17666407

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NUDT3
    DNA2.0 Custom Variant and Variant Library Synthesis for NUDT3

    Disorders / Diseases
    for NUDT3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NUDT3 for disorders           About MalaCards
    OMIM gene information: 609228    OMIM disorders: --


    NUDT3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NUDT3

    Export disorders for NUDT3 gene to outside databases

    Publications
    for NUDT3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NUDT3 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with NUDT3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase. (PubMed id 9822604)1, 2, 3, 9 Safrany S.T.... Shears S.B. (1998)
    2. Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate. (PubMed id 12370170)1, 2, 9 Fisher D.I.... Cartwright J.L. (2002)
    3. The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein. (PubMed id 10419486)1, 2, 9 Safrany S.T.... Shears S.B. (1999)
    4. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PubMed id 20935630)1, 4 Speliotes E.K....Loos R.J. (2010)
    5. Identification of 15 loci influencing height in a Kor ean population. (PubMed id 19893584)1, 4 Kim J.J....Lee J.K. (2010)
    6. Crystal structure of human diphosphoinositol phosphat ase 1. (PubMed id 19585659)1, 2 Thorsell A.G....Hallberg B.M. (2009)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    9. Site-directed mutagenesis of diphosphoinositol polyphosphate phosphohydrolase, a dual specificity NUDT enzyme that attacks diadenosine polyphosphates and diphosphoinositol polyphosphates. (PubMed id 10585413)1, 2 Yang X.... Shears S.B. (1999)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    External Searches for NUDT3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NUDT3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11165 HGNC: 8050 AceView: NUDT3.1 Ensembl:ENSG00000272325 euGenes: HUgn11165
    ECgene: NUDT3 H-InvDB: NUDT3

    Other Databases showing NUDT3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NUDT3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NUDT3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NUDT3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NUDT3 gene:
    Search GeneIP for patents involving NUDT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for NUDT3 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for NUDT3  
     OriGene qPCR primer pairs and template standards for NUDT3   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for NUDT3  
     OriGene qSTAR qPCR primer pairs in human, mouse for NUDT3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for NUDT3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NUDT3   OriGene Custom Protein Services for NUDT3  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NUDT3
     QIAGEN SeqTarget long-range PCR primers for resequencing NUDT3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUDT3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUDT3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUDT3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUDT3
     GenScript Custom Purified and Recombinant Proteins Services for NUDT3 GenScript cDNA clones with any tag delivered in your preferred vector for NUDT3
     GenScript Custom Assay Services for NUDT3 GenScript Custom Superior Antibodies Services for NUDT3
     GenScript Custom overexpressing Cell Line Services for NUDT3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NUDT3 promoter
     Search Chromatin IP Primers for NUDT3
     RT2 qPCR Primer Assay in human, mouse, rat NUDT3
     Search GNC Networks for NUDT3
     SABiosciences Custom PCR Arrays for NUDT3
     Search Tocris compounds for NUDT3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NUDT3 antibodies
     NUDT3 proteins
     NUDT3 lysates
     Antibodies for NUDT3
     See all of Abcam's Antibodies, Kits and Proteins for NUDT3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for NUDT3




     Proteins for NUDT3
     Antibodies for NUDT3
     ELISAs for NUDT3
     CLIAs for NUDT3
     Search LifeMap BioReagents cell lines for NUDT3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT3
     SwitchGear 3'UTR luciferase reporter plasmids for NUDT3
     SwitchGear Promoter luciferase reporter plasmids for NUDT3
     ThermoFisher Antibodies for NUDT3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUDT3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for NUDT3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NUDT3
    Customized:
     lentivirus for stable overexpression of NUDT3
     lentivirus expression plasmids for stable overexpression of NUDT3
     adenovirus for overexpression of NUDT3
     LSBio Antibodies in human, mouse, rat for NUDT3
    		Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2014 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      NUDT3 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4