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NUDT3 Gene

protein-coding GIFtS: 55
GCID: GC06M035727

Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif...

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 3¹ ²		DIPP-1² ³
Diadenosine 5',5'''-P1,P6-Hexaphosphate Hydrolase 1² ³		DIPP1² ³
Nucleoside Diphosphate-Linked Moiety X Motif 3² ³		Diphosphoinositol Polyphosphate Phosphohydrolase 1²
Nudix Motif 3² ³		EC 3.6.1.-³
DIPP² ³		EC 3.6.1.52³

External Ids:	HGNC: 8050¹	Entrez Gene: 11165²	Ensembl: ENSG00000272325⁷	OMIM: 609228⁵	UniProtKB: O95989³

Export aliases for NUDT3 gene to outside databases

Previous GC identifers: GC06M034258 GC06M034302 GC06M034363 GC06M033978 GC06M034388 GC06M034894 GC06M035232

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NUDT3 Gene:

NUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act as homeostatic checkpoints at important

stages in nucleoside phosphate metabolic pathways, guarding against elevated levels of potentially dangerous

intermediates, like 8-oxo-dGTP, which promotes AT-to-CG transversions (Safrany et al., 1998 (PubMed

9822604)).(supplied by OMIM, Feb 2011)

GeneCards Summary for NUDT3 Gene:

NUDT3 (nudix (nucleoside diphosphate linked moiety X)-type motif 3) is a protein-coding gene. GO annotations related to this gene include inositol diphosphate tetrakisphosphate diphosphatase activity and magnesium ion binding. An important paralog of this gene is NUDT4.

UniProtKB/Swiss-Prot: NUDT3_HUMAN, O95989

Function: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate)

and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal

transduction. InsP6 (inositol hexakisphophate) is not a substrate. Acts as a negative regulator of the ERK1/2

pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the

preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able

to hydrolyze 5-phosphoribose 1-diphosphate

Gene Wiki entry for NUDT3 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000006.11 NC_018917.2 NT_007592.16

Regulatory elements:

Regulatory transcription factor binding sites in the NUDT3 gene promoter:
STAT5B NF-1/L AML1a FOXD3 E47 C/EBPalpha Hand1 Chx10 SEF-1 (1) Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NUDT3 promoter sequence

Search Chromatin IP Primers for NUDT3

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NUDT3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.2 Ensembl cytogenetic band: 6p21.31 HGNC cytogenetic band: 6p21.2

NUDT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUDT3 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M035727: view genomic region (about GC identifiers)

Start:	34,247,456 bp from pter	End:	34,360,457 bp from pter
Size:	113,002 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NUDT3_HUMAN, O95989 (See protein sequence)

Recommended Name: Diphosphoinositol polyphosphate phosphohydrolase 1

Size: 172 amino acids; 19471 Da

Cofactor: Binds 3 magnesium ions per subunit

Subunit: Monomer (By similarity)

2 PDB 3D structures from and Proteopedia for NUDT3:

2FVV (3D)

2Q9P (3D)

Secondary accessions: B2R8N4

Explore the universe of human proteins at neXtProt for NUDT3: NX_O95989

Explore proteomics data for NUDT3 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See NUDT3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_006694.1

ENSEMBL proteins:

ENSP00000476119

Reactome Protein details: O95989

NUDT3 Human Recombinant Protein Products:

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	antibodies-online peptides for NUDT3

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

NUDT: Nudix motif containing

3 InterPro protein domains:

IPR015797 NUDIX_hydrolase_dom-like

IPR020084 NUDIX_hydrolase_CS

IPR000086 NUDIX_hydrolase_dom

Graphical View of Domain Structure for InterPro Entry O95989

ProtoNet protein and cluster: O95989

1 Blocks protein domain: IPB000086 NUDIX hydrolase

UniProtKB/Swiss-Prot: NUDT3_HUMAN, O95989

Similarity: Belongs to the Nudix hydrolase family. DIPP subfamily

Similarity: Contains 1 nudix hydrolase domain

Find genes that share domains with NUDT3 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: NUDT3_HUMAN, O95989

Function: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate)

and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal

transduction. InsP6 (inositol hexakisphophate) is not a substrate. Acts as a negative regulator of the ERK1/2

pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the

preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able

to hydrolyze 5-phosphoribose 1-diphosphate

Catalytic activity: Diphospho-myo-inositol polyphosphate + H(2)O = myo-inositol polyphosphate + phosphate

Enzyme regulation: Inhibited by fluoride and InsP6

Biophysicochemical properties: Kinetic parameters: KM=5.9 uM for Ap6A; KM=7.7 uM for Ap5A; KM=38 mM for

5-phosphoribose 1-diphosphate; KM=4.2 nM for PP-InsP5; pH dependence: Optimum pH is 7-7.5;

Genatlas biochemistry entry for NUDT3:

nudix (nucleoside diphosphate linked moiety X)-type motif 3,hydrolase,most predominantly expressed in

brain,heart,pancreas,liver,putative mouse cleaning gene whose functions is to cleanse the cell of potentially

deleterious endogenous metabolites and to modulate the accumulation of intermediates in biochemical pathways

Enzyme Numbers (IUBMB): EC 3.6.1.52¹ EC 3.6.1.-¹

Gene Ontology (GO): Selected molecular function terms (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000287	magnesium ion binding	IDA	19585659
GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity	IDA	10585413
GO:0016787	hydrolase activity	--	--
GO:0052840	inositol diphosphate tetrakisphosphate diphosphatase activity	IEA	--
GO:0052843	inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity	IEA	--

Find genes that share ontologies with NUDT3 About GenesLikeMe

Phenotypes:
3 GenomeRNAi human phenotypes for NUDT3:

Decreased Hepatitis C virus re

Decreased TP53 protein express

Synthetic lethal with imatinib

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for NUDT3

miRNA Products:		miRTarBase miRNAs that target NUDT3: hsa-mir-16-5p (MIRT051285), hsa-mir-766-3p (MIRT039048)

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		SwitchGear 3'UTR luciferase reporter plasmid: NUDT3 3' UTR sequence

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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

NUDT3_HUMAN, O95989: Cytoplasm (Probable)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytosol	4
nucleus	3

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Gene Ontology (GO): 1 cellular component term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for NUDT3 About

See pathways by source

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SuperPath

Contained pathways About

Inositol phosphate metabolism (REACTOME)

Inositol phosphate metabolism

0.59

Synthesis of pyrophosphates in the cytosol

0.00

Metabolism

Metabolism

0.38

Find genes that share SuperPaths with NUDT3 About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

1 Reactome Pathway for NUDT3

Synthesis of pyrophosphates in the cytosol

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for NUDT3
Interactions:

Search GeneGlobe Interaction Network for NUDT3

Selected Interacting proteins for NUDT3 (O95989^{2, 3}) via UniProtKB, MINT, STRING, and/or I2D (see all 40)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DDR1	Q08345²^,³	MINT-8264722 I2D: score=2
ENSG00000137332	Q08345²^,³	MINT-8264722 I2D: score=2
ENSG00000215522	Q08345²^,³	MINT-8264722 I2D: score=2
ENSG00000230456	Q08345²^,³	MINT-8264722 I2D: score=2
ENSG00000234078	Q08345²^,³	MINT-8264722 I2D: score=2

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Gene Ontology (GO): 5 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007267	cell-cell signaling	TAS	10419486
GO:0015961	diadenosine polyphosphate catabolic process	TAS	10419486
GO:0043647	inositol phosphate metabolic process	TAS	--
GO:0044281	small molecule metabolic process	TAS	--
GO:0071544	diphosphoinositol polyphosphate catabolic process	IDA	10585413

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for NUDT3

6 HMDB Compounds for NUDT3 About this table

Compound	Synonyms	CAS #	PubMed Ids
5-Diphosphoinositol pentakisphosphate	5-diphospho-1D-myo-inositol pentakisphosphate (see all 11)	--	--
Diadenosine hexaphosphate	Adenosine 5'-(heptahydrogen hexaphosphate) P->5'-ester with adenosine (see all 9)	56983-23-4	--
Magnesium	Magnesium (see all 2)	7439-95-4	--
Myo-inositol hexakisphosphate	1D-myo-Inositol 1,2,3,4,5,6-hexakisphosphate (see all 9)	83-86-3	--
Phosphate	NFB Orthophosphate (see all 13)	14265-44-2	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

4 Novoseek inferred chemical compound relationships for NUDT3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ap(6)a	93.8	1	10419486 (1)
dipp	91.4	7	9822604 (3), 12370170 (2)
prpp	76.3	4	12370170 (2)
pyrophosphate	57.4	3	9822604 (1), 15212765 (1)

Find genes that share compounds with NUDT3 About GenesLikeMe

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for NUDT3 gene:

NM_006703.3

Unigene Cluster for NUDT3:

Nudix (nucleoside diphosphate linked moiety X)-type motif 3

Hs.188882 [show with all ESTs]

Unigene Representative Sequence: NM_001202470

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000607016

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		QuantiFast Probe-based Assays in human, mouse, rat NUDT3

Additional mRNA sequence:

AF062529.1 AF062530.1 AK124804.1 AK313440.1 BC007727.2 BT019984.1 BT019985.1

Selected DOTS entries (see all 27):

DT.100816157 DT.318336 DT.100646332 DT.91865700 DT.99960049 DT.121358641 DT.121358935 DT.100816158

DT.95339214 DT.318334 DT.121359042 DT.40219001 DT.100741966 DT.121359032 DT.97804088 DT.100741970

DT.100742004 DT.100816155 DT.100851413 DT.102845466 DT.120731171 DT.121358763 DT.87009604 DT.91780069

4 AceView cDNA sequences:

BC024593 AW875186 BE888564 BF805177

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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NUDT3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ATCTGTCCCT

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NUDT3 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

NUDT3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.188882

UniProtKB/Swiss-Prot: NUDT3_HUMAN, O95989

Tissue specificity: Widely expressed. Expressed at higher level in brain, heart, pancreas and liver. Also

expressed in placenta, lung and kidney

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for NUDT3 gene from Selected species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Nudt3^{1 , 5}	nudix (nucleotide diphosphate linked moiety X)-type more^{1, 5}	91.07(n)¹ 97.62(a)¹		17 (14.59 cM)⁵ 56409¹ NM_019837.2¹ NP_062811.1¹ 27579382⁵
chicken (Gallus gallus)	Aves	NUDT3¹	nudix (nucleoside diphosphate linked moiety X)-type more	85.8(n) 93.49(a)		419905 NM_001257298.1 NP_001244227.1
lizard (Anolis carolinensis)	Reptilia	NUDT3⁶	nudix (nucleoside diphosphate linked moiety X)-typ...	91(a)	1 ↔ 1	4(121456909-121489247)
zebrafish (Danio rerio)	Actinopterygii	zgc55746²	similar to nudix (nucleotide diphosphate linked moiety more	80.47(n)		394120 BC048064.1
fruit fly (Drosophila melanogaster)	Insecta	CG6391³ Aps¹	diphosphoinositol-polyphosphate diphosphatase³ Aps¹	57(a)³ 56.04(n)¹ 57.5(a)¹		67F3³ 39226¹ NM_140164.3¹ NP_648421.1¹
worm (Caenorhabditis elegans)	Secernentea	Y92H12BL.5¹	Y92H12BL.5	49.48(n) 43.75(a)		259365 NM_170801.5 NP_740784.1

ENSEMBL Gene Tree for NUDT3 (if available)
TreeFam Gene Tree for NUDT3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for NUDT3 gene

NUDT4² NUDT11² NUDT10²

4 SIMAP similar genes for NUDT3 using alignment to 1 protein entry: NUDT3_HUMAN:

NUDT4 NUDT10 NUDT11 RPS10-NUDT3

Find genes that share paralogs with NUDT3 About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Structural Variations
Database of Genomic Variants (DGV) 6 variations for NUDT3: About this table

Variant ID	Type	Subtype	PubMed ID
esv2674771	CNV	Deletion	23128226
esv2731907	CNV	Deletion	23290073
dgv1115e199	CNV	Deletion	23128226
nsv5253	CNV	Insertion	18451855
esv29044	CNV	Loss	19812545
esv33496	CNV	Loss	17666407

Site Specific Mutation Identification with PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 609228 OMIM disorders: --

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Genetic Association Database (GAD): NUDT3

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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for NUDT3 gene, integrated from 10 sources (see all 29):
(articles sorted by number of sources associating them with NUDT3)

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A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase. (PubMed id 9822604)^{1, 2, 3, 9} Safrany S.T.... Shears S.B. (EMBO J. 1998)
Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate. (PubMed id 12370170)^{1, 2, 9} Fisher D.I.... Cartwright J.L. (J. Biol. Chem. 2002)
The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein. (PubMed id 10419486)^{1, 2, 9} Safrany S.T.... Shears S.B. (J. Biol. Chem. 1999)
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PubMed id 20935630)^{1, 4} Speliotes E.K....Loos R.J. (Nat. Genet. 2010)
Identification of 15 loci influencing height in a Korean population. (PubMed id 19893584)^{1, 4} Kim J.J....Lee J.K. (J. Hum. Genet. 2010)
Crystal structure of human diphosphoinositol phosphatase 1. (PubMed id 19585659)^{1, 2} Thorsell A.G....Hallberg B.M. (Proteins 2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (Nature 2003)
Site-directed mutagenesis of diphosphoinositol polyphosphate phosphohydrolase, a dual specificity NUDT enzyme that attacks diadenosine polyphosphates and diphosphoinositol polyphosphates. (PubMed id 10585413)^{1, 2} Yang X.... Shears S.B. (J. Biol. Chem. 1999)
NUDT3 rs206936 is associated with body mass index in obese Japanese women. (PubMed id 23708086)¹ Kitamoto A....Hotta K. (Endocr. J. 2013)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 11165	HGNC: 8050	AceView: NUDT3.1	Ensembl:ENSG00000272325	euGenes: HUgn11165
ECgene: NUDT3	H-InvDB: NUDT3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for NUDT3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NUDT3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NUDT3 gene:
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