NUDT22 Gene
protein-coding GIFtS: 40
GCID: GC11P063993
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nudix (nucleoside diphosphate linked moiety X)-type motif...
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Aliases
for NUDT22 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 221 2 | | Nudix Motif 222 3 | | MGC130451 | | Nucleoside Diphosphate-Linked Moiety X Motif 222 |
Export aliases for NUDT22 gene to outside databasesPrevious GC identifers: GC11P063751 GC11P060322 |
Summaries
for NUDT22 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for NUDT22 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NUDT22 gene promoter:
Max1 ER-alpha RFX1 Pax-2 Pax-2a CP2 SEF-1 (1) AP-2beta AP-2alpha NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NUDT22
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUDT22 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13.1 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13.1NUDT22 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P063993: view genomic region
(about GC identifiers)
Start:
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63,993,413 bp from pter |
End:
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63,998,158 bp from pter |
Size:
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4,746 bases |
Orientation:
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plus strand |
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Proteins
for NUDT22 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NUD22_HUMAN, Q9BRQ3 (See
protein sequence)Recommended Name: Nucleoside diphosphate-linked moiety X motif 22 Size: 303 amino acids; 32580 Da
Secondary accessions: Q71RD5Alternative splicing: 2 isoforms: Q9BRQ3-1 Q9BRQ3-2 Explore the universe of human proteins at neXtProt for NUDT22: NX_Q9BRQ3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BRQ3
NUDT22 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001122084.1 NP_001122085.1 NP_001258760.1 NP_115720.1
ENSEMBL proteins: ENSP00000444022 ENSP00000442014 ENSP00000440166 ENSP00000407970 ENSP00000279206 ENSP00000401085 ENSP00000443127
Human Recombinant Protein Products for NUDT22:
NUDT22 Antibody Products:
Assay Products for NUDT22: |
Protein
Domains /
Families
for NUDT22 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NUDT22 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BRQ3ProtoNet protein and cluster: Q9BRQ3 1 Blocks protein family: IPB000086 NUDIX hydrolase
UniProtKB/Swiss-Prot: NUD22_HUMAN, Q9BRQ3Domain: Although related to the NUDIX hydrolase family, it lacks the Nudix box and does not seem to act as a hydrolaseSimilarity: Belongs to the Nudix hydrolase familySimilarity: Contains 1 nudix hydrolase domain |
Function
for NUDT22 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016787 | hydrolase activity |
IEA | -- |
NUDT22 for ontologies About GeneDecksing
Phenotypes:
1 MGI phenotypic allele  for Nudt22 (no phenotypes)
NUDT22 for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT22 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT22 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): NUDT22 (NM_001128612) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NUDT22 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUDT22 |
|
Pathways & Interactions
for NUDT22 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NUDT22
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for NUDT22 (ENSP000002792064) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for NUDT22 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NUDT22
Search CenterWatch for drugs/clinical trials and news about NUDT22 / NUD22
|
Transcripts
for NUDT22 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NUDT22 gene (4 alternative transcripts): NM_001128612.2 NM_001128613.2 NM_001271831.1 NM_032344.3 Unigene Clusters for NUDT22: Nudix (nucleoside diphosphate linked moiety X)-type motif 22 Hs.656074 [show with all ESTs], Hs.744098 [show with all ESTs]Unigene Representative Sequences: AF370402, NM_03234412 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000539325 ENST00000543358 ENST00000422364 ENST00000535000 ENST00000441250
ENST00000279206(uc001nyp.4 uc009ype.3 uc001nyq.4 uc010rng.2)
ENST00000537707(uc009ypd.3) ENST00000428347 ENST00000537094 ENST00000543501
ENST00000545184 ENST00000534929
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT22 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT22 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): NUDT22 (NM_001128612) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NUDT22 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUDT22 |
Additional cDNA sequence: BC006129.1 13 DOTS entries: DT.446112 DT.100792956 DT.100807942 DT.95335555 DT.120757681 DT.100792951 DT.101960956 DT.100791224 DT.100767500 DT.92406018 DT.92466599 DT.95335545 DT.95335557 24/242 AceView cDNA sequences (see all 242): AI761257 BF197628 BU528228 AW384523 BE675994 BM558796 AA326970 AI738998 BU171233 AI192962 AI363182 AI015916 AW384485 AI078588 BM310766 CB070105 AI749898 BF058544 BM714130 BF433833 AI699611 AI424276 BC051008 CR615814
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for NUDT22 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 |
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| SP1: | | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | - | | - | | | | - | | | |
ECgene alternative splicing isoforms for NUDT22
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Expression
for NUDT22 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NUDT22 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACTCTTTTC
About this image
See NUDT22 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NUDT22
SOURCE GeneReport for Unigene clusters: Hs.656074 Hs.744098
SABiosciences Custom PCR Arrays for NUDT22
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUDT22
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NUDT22 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUDT22 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUDT22 |
Orthologs
for NUDT22 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for NUDT22 gene from 6/18 species (see all 18) About this table
ENSEMBL Gene Tree for NUDT22 (if available)
TreeFam Gene Tree for NUDT22 (if available) |
Paralogs
for NUDT22 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for NUDT22 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NUDT22 |
|
Disorders
/ Diseases
for NUDT22 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NUDT22 for disorders About GeneDecksing
2  diseases for NUDT22: About MalaCardshepatitis b hepatitis
Human Genome Epidemiology (HuGE) Navigator: NUDT22 (4 documents)
Export disorders for NUDT22 gene to outside databases
|
Publications
for NUDT22 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NUDT22 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with NUDT22) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Genome-wide association study of the child behavior c hecklist dysregulation profile. (PubMed id 21784300)1 Mick E....Faraone S.V. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
|
External Searches for NUDT22 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing NUDT22 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NUDT22 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NUDT22 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NUDT22 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NUDT22 gene:
Search GeneIP for patents involving NUDT22
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NUDT22 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NUDT22 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NUDT22 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUDT22 | | | OriGene Protein Over-expression Lysate for NUDT22 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NUDT22 | | OriGene 3'-UTR Clone for NUDT22 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT22 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT22 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for NUDT22 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NUDT22 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NUDT22 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUDT22 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUDT22 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUDT22 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUDT22 |
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 | | | NUDT22 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | Search ThermoFisher Antibodies for NUDT22 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUDT22 |
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