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Aliases for NUDT22 Gene

Aliases for NUDT22 Gene

  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 22 2 3
  • Nudix Motif 22 4

External Ids for NUDT22 Gene

Summaries for NUDT22 Gene

GeneCards Summary for NUDT22 Gene

NUDT22 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 22) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT22 Gene

Genomics for NUDT22 Gene

Genomic Location for NUDT22 Gene

Start:
64,225,941 bp from pter
End:
64,230,686 bp from pter
Size:
4,746 bases
Orientation:
Plus strand

Genomic View for NUDT22 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUDT22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT22 Gene

Regulatory Elements for NUDT22 Gene

Proteins for NUDT22 Gene

  • Protein details for NUDT22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRQ3-NUD22_HUMAN
    Recommended name:
    Nucleoside diphosphate-linked moiety X motif 22
    Protein Accession:
    Q9BRQ3
    Secondary Accessions:
    • C9JY06
    • Q71RD5

    Protein attributes for NUDT22 Gene

    Size:
    303 amino acids
    Molecular mass:
    32580 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NUDT22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUDT22 Gene

Proteomics data for NUDT22 Gene at MOPED

Post-translational modifications for NUDT22 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys60

No data available for DME Specific Peptides for NUDT22 Gene

Domains for NUDT22 Gene

Gene Families for NUDT22 Gene

HGNC:
  • NUDT :Nudix motif containing

Protein Domains for NUDT22 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

NUD22_HUMAN
Domain:
  • Although related to the NUDIX hydrolase family, it lacks the Nudix box and does not seem to act as a hydrolase:
    • Q9BRQ3
  • Contains 1 nudix hydrolase domain.:
    • Q9BRQ3
Family:
  • Belongs to the Nudix hydrolase family.:
    • Q9BRQ3
genes like me logo Genes that share domains with NUDT22: view

Function for NUDT22 Gene

Gene Ontology (GO) - Molecular Function for NUDT22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with NUDT22: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NUDT22 Gene

Localization for NUDT22 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUDT22 Gene COMPARTMENTS Subcellular localization image for NUDT22 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for NUDT22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with NUDT22: view

Pathways for NUDT22 Gene

SuperPathways for NUDT22 Gene

No Data Available

Interacting Proteins for NUDT22 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000279206%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000221561%0d%0a
Selected Interacting proteins: ENSP00000279206 Q9BRQ3-NUD22_HUMAN for NUDT22 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for NUDT22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with NUDT22: view

No data available for Pathways by source for NUDT22 Gene

Transcripts for NUDT22 Gene

Unigene Clusters for NUDT22 Gene

Nudix (nucleoside diphosphate linked moiety X)-type motif 22:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT22 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: -
SP2: - -
SP3:
SP4: - -
SP5: - - - - -
SP6: - -

Relevant External Links for NUDT22 Gene

GeneLoc Exon Structure for
NUDT22
ECgene alternative splicing isoforms for
NUDT22

Expression for NUDT22 Gene

mRNA expression in normal human tissues for NUDT22 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUDT22 Gene

SOURCE GeneReport for Unigene cluster for NUDT22 Gene Hs.656074

genes like me logo Genes that share expressions with NUDT22: view

Orthologs for NUDT22 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUDT22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUDT22 36
  • 99.45 (n)
  • 99.34 (a)
NUDT22 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NUDT22 36
  • 87.93 (n)
  • 86.9 (a)
NUDT22 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUDT22 36
  • 86.51 (n)
  • 86.51 (a)
NUDT22 37
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nudt22 36
  • 85.63 (n)
  • 85.87 (a)
Nudt22 16
Nudt22 37
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NUDT22 37
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nudt22 36
  • 86.22 (n)
  • 85.16 (a)
lizard
(Anolis carolinensis)
Reptilia NUDT22 37
  • 59 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia P17F11 36
tropical clawed frog
(Silurana tropicalis)
Amphibia nudt22 36
  • 55.16 (n)
  • 57.65 (a)
Str.502 36
zebrafish
(Danio rerio)
Actinopterygii nudt22 36
  • 58.3 (n)
  • 55.48 (a)
nudt22 37
  • 46 (a)
OneToOne
wufb64h05 36
thale cress
(Arabidopsis thaliana)
eudicotyledons NUDT9 36
  • 43.66 (n)
  • 39.55 (a)
rice
(Oryza sativa)
Liliopsida Os05g0117500 36
  • 43.36 (n)
  • 35.37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 38 (a)
OneToOne
Species with no ortholog for NUDT22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUDT22 Gene

ENSEMBL:
Gene Tree for NUDT22 (if available)
TreeFam:
Gene Tree for NUDT22 (if available)

Paralogs for NUDT22 Gene

No data available for Paralogs for NUDT22 Gene

Variants for NUDT22 Gene

Sequence variations from dbSNP and Humsavar for NUDT22 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs537115310 -- 64,228,268(+) ACCTT(C/T)GCCTC intron-variant
VAR_029616 -
VAR_029617 -
VAR_029618 -
VAR_050414 -

Structural Variations from Database of Genomic Variants (DGV) for NUDT22 Gene

Variant ID Type Subtype PubMed ID
dgv1156n71 CNV Loss 21882294
nsv469961 CNV Loss 18288195
dgv1163n71 CNV Loss 21882294
dgv1164n71 CNV Loss 21882294
dgv1165n71 CNV Loss 21882294
dgv1166n71 CNV Loss 21882294
nsv832186 CNV Loss 17160897
dgv1167n71 CNV Loss 21882294
esv992196 CNV Deletion 20482838
nsv897674 CNV Loss 21882294

Relevant External Links for NUDT22 Gene

HapMap Linkage Disequilibrium report
NUDT22

Disorders for NUDT22 Gene

Relevant External Links for NUDT22

Genetic Association Database (GAD)
NUDT22
Human Genome Epidemiology (HuGE) Navigator
NUDT22
genes like me logo Genes that share disorders with NUDT22: view

No data available for UniProtKB/Swiss-Prot for NUDT22 Gene

Publications for NUDT22 Gene

  1. Genome-wide association study of the child behavior checklist dysregulation profile. (PMID: 21784300) Mick E. … Faraone S.V. (J Am Acad Child Adolesc Psychiatry 2011) 3 49
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 49
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for NUDT22 Gene

Sources for NUDT22 Gene

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