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Aliases for NUDT22 Gene

Aliases for NUDT22 Gene

  • Nudix Hydrolase 22 2 3 5
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 22 2
  • Nudix Motif 22 4

External Ids for NUDT22 Gene

Previous GeneCards Identifiers for NUDT22 Gene

  • GC11P063751
  • GC11P063993
  • GC11P060322

Summaries for NUDT22 Gene

GeneCards Summary for NUDT22 Gene

NUDT22 (Nudix Hydrolase 22) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT22 Gene

Genomics for NUDT22 Gene

Regulatory Elements for NUDT22 Gene

Promoters for NUDT22 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NUDT22 on UCSC Golden Path with GeneCards custom track

Genomic Location for NUDT22 Gene

Chromosome:
11
Start:
64,225,941 bp from pter
End:
64,230,686 bp from pter
Size:
4,746 bases
Orientation:
Plus strand

Genomic View for NUDT22 Gene

Genes around NUDT22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDT22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDT22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT22 Gene

Proteins for NUDT22 Gene

  • Protein details for NUDT22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRQ3-NUD22_HUMAN
    Recommended name:
    Nucleoside diphosphate-linked moiety X motif 22
    Protein Accession:
    Q9BRQ3
    Secondary Accessions:
    • C9JY06
    • Q71RD5

    Protein attributes for NUDT22 Gene

    Size:
    303 amino acids
    Molecular mass:
    32580 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NUDT22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUDT22 Gene

Proteomics data for NUDT22 Gene at MOPED

Post-translational modifications for NUDT22 Gene

  • Ubiquitination at Lys 60
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NUDT22 Gene

Domains & Families for NUDT22 Gene

Gene Families for NUDT22 Gene

Protein Domains for NUDT22 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NUDT22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRQ3

UniProtKB/Swiss-Prot:

NUD22_HUMAN :
  • Although related to the NUDIX hydrolase family, it lacks the Nudix box and does not seem to act as a hydrolase.
  • Belongs to the Nudix hydrolase family.
Domain:
  • Although related to the NUDIX hydrolase family, it lacks the Nudix box and does not seem to act as a hydrolase.
  • Contains 1 nudix hydrolase domain.
Family:
  • Belongs to the Nudix hydrolase family.
genes like me logo Genes that share domains with NUDT22: view

Function for NUDT22 Gene

Gene Ontology (GO) - Molecular Function for NUDT22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NUDT22: view

Phenotypes for NUDT22 Gene

genes like me logo Genes that share phenotypes with NUDT22: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NUDT22

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NUDT22 Gene

Localization for NUDT22 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUDT22 Gene COMPARTMENTS Subcellular localization image for NUDT22 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NUDT22 Gene

Pathways & Interactions for NUDT22 Gene

SuperPathways for NUDT22 Gene

No Data Available

Interacting Proteins for NUDT22 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000279206%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000221561%0d%0a
Selected Interacting proteins: Q9BRQ3-NUD22_HUMAN ENSP00000279206 for NUDT22 Gene via UniProtKB STRING

Gene Ontology (GO) - Biological Process for NUDT22 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NUDT22 Gene

Drugs & Compounds for NUDT22 Gene

No Compound Related Data Available

Transcripts for NUDT22 Gene

Unigene Clusters for NUDT22 Gene

Nudix (nucleoside diphosphate linked moiety X)-type motif 22:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT22 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: -
SP2: - -
SP3:
SP4: - -
SP5: - - - - -
SP6: - -

Relevant External Links for NUDT22 Gene

GeneLoc Exon Structure for
NUDT22
ECgene alternative splicing isoforms for
NUDT22

Expression for NUDT22 Gene

mRNA expression in normal human tissues for NUDT22 Gene

Protein differential expression in normal tissues from HIPED for NUDT22 Gene

This gene is overexpressed in Fetal gut (64.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUDT22 Gene



SOURCE GeneReport for Unigene cluster for NUDT22 Gene Hs.656074

genes like me logo Genes that share expression patterns with NUDT22: view

Protein tissue co-expression partners for NUDT22 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NUDT22 Gene

Orthologs for NUDT22 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUDT22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUDT22 36
  • 99 (a)
OneToOne
NUDT22 35
  • 99.45 (n)
  • 99.34 (a)
cow
(Bos Taurus)
Mammalia NUDT22 36
  • 87 (a)
OneToOne
NUDT22 35
  • 87.93 (n)
  • 86.9 (a)
dog
(Canis familiaris)
Mammalia NUDT22 35
  • 86.51 (n)
  • 86.51 (a)
NUDT22 36
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nudt22 16
Nudt22 36
  • 81 (a)
OneToOne
Nudt22 35
  • 85.63 (n)
  • 85.87 (a)
oppossum
(Monodelphis domestica)
Mammalia NUDT22 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nudt22 35
  • 86.22 (n)
  • 85.16 (a)
lizard
(Anolis carolinensis)
Reptilia NUDT22 36
  • 59 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia P17F11 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nudt22 35
  • 55.16 (n)
  • 57.65 (a)
Str.502 35
zebrafish
(Danio rerio)
Actinopterygii nudt22 36
  • 46 (a)
OneToOne
nudt22 35
  • 58.3 (n)
  • 55.48 (a)
wufb64h05 35
thale cress
(Arabidopsis thaliana)
eudicotyledons NUDT9 35
  • 43.66 (n)
  • 39.55 (a)
rice
(Oryza sativa)
Liliopsida Os05g0117500 35
  • 43.36 (n)
  • 35.37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToOne
Species with no ortholog for NUDT22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUDT22 Gene

ENSEMBL:
Gene Tree for NUDT22 (if available)
TreeFam:
Gene Tree for NUDT22 (if available)

Paralogs for NUDT22 Gene

No data available for Paralogs for NUDT22 Gene

Variants for NUDT22 Gene

Sequence variations from dbSNP and Humsavar for NUDT22 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_029616 -
VAR_029617 -
VAR_029618 -
VAR_050414 -

Structural Variations from Database of Genomic Variants (DGV) for NUDT22 Gene

Variant ID Type Subtype PubMed ID
dgv1156n71 CNV Loss 21882294
nsv469961 CNV Loss 18288195
dgv1163n71 CNV Loss 21882294
dgv1164n71 CNV Loss 21882294
dgv1165n71 CNV Loss 21882294
dgv1166n71 CNV Loss 21882294
nsv832186 CNV Loss 17160897
dgv1167n71 CNV Loss 21882294
esv992196 CNV Deletion 20482838
nsv897674 CNV Loss 21882294

Variation tolerance for NUDT22 Gene

Residual Variation Intolerance Score: 87.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.15; 80.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUDT22 Gene

HapMap Linkage Disequilibrium report
NUDT22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT22 Gene

Disorders for NUDT22 Gene

Relevant External Links for NUDT22

Genetic Association Database (GAD)
NUDT22
Human Genome Epidemiology (HuGE) Navigator
NUDT22
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUDT22

No disorders were found for NUDT22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUDT22 Gene

Publications for NUDT22 Gene

  1. Genome-wide association study of the child behavior checklist dysregulation profile. (PMID: 21784300) Mick E. … Faraone S.V. (J Am Acad Child Adolesc Psychiatry 2011) 3 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3

Products for NUDT22 Gene

Sources for NUDT22 Gene

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