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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NUDT21 Gene

protein-coding   GIFtS: 53
GCID: GC16M056463

nudix (nucleoside diphosphate linked moiety X)-type motif...

(Previous names: cleavage and polyadenylation specific factor 5, 25 kDa,...)
(Previous symbol: CPSF5)
 Explore 2 diseases affiliated with
NUDT21 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NUDT21    

Aliases
for NUDT21 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 211 2     Pre-MRNA Cleavage Factor Im 25 KDa Subunit2 3
CFIM251 2 3 5     CPSF 25 KDa Subunit2 3
CPSF51 2 3 5     Cleavage And Polyadenylation Specificity Factor Subunit 52
Cleavage And Polyadenylation Specific Factor 5, 25 KD Subunit1 2     Pre-MRNA Cleavage Factor Im (25kD)2
Cleavage And Polyadenylation Specific Factor 5, 25 KDa1 2     Pre-MRNA Cleavage Factor Im, 25kD Subunit2
Cleavage And Polyadenylation Specificity Factor 25 KDa Subunit2 3     CFIm253
Nucleoside Diphosphate-Linked Moiety X Motif 212 3     CPSF253
Nudix Motif 212 3     

External Ids:    HGNC: 138701   Entrez Gene: 110512   Ensembl: ENSG000001670057   OMIM: 6049785   UniProtKB: O438093   

Export aliases for NUDT21 gene to outside databases

Previous GC identifers: GC16M055021 GC16M042333


Summaries
for NUDT21 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NUDT21:
The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation
processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end
processing complex and facilitates the recruitment of other processing factors. This gene encodes the 25kD subunit of
the protein complex, which is composed of four polypeptides. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CPSF5_HUMAN, O43809
Function: Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved
in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds
to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of
two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May
have a role in mRNA export

Gene Wiki entry for NUDT21


Genomic Views
for NUDT21 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NUDT21 gene promoter:
         AML1a   STAT5A   Nkx2-5   E47   GATA-1   AREB6   GATA-6   CP2   HFH-1   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NUDT21 promoter sequence
   Search SABiosciences Chromatin IP Primers for NUDT21

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUDT21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q12.2   Ensembl cytogenetic band:  16q12.2   HGNC cytogenetic band: 16q12.2

NUDT21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUDT21 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M056463:  view genomic region     (about GC identifiers)

Start:
 56,463,045 bp from pter      End:
 56,486,111 bp from pter
Size:
 23,067 bases      Orientation:
 minus strand

Proteins
for NUDT21 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CPSF5_HUMAN, O43809 (See protein sequence)
Recommended Name: Cleavage and polyadenylation specificity factor subunit 5  
Size: 227 amino acids; 26227 Da
Subunit: Homodimer. Component of the cleavage factor Im (CFIm) complex, composed of, at least, NUDT21/CPSF5 and CPSF6
or CPSF7. Within the cleavage factor Im complex, the NUDT21/CPSF5 homodimer is at the core of a heterotetramer, and is
clasped by two additional subunits (CPSF6 or CPSF7). Interacts with CPSF6, CPSF7, PABPN1 and SNRNP70. Interacts with
PAPOLA; the interaction is diminished by acetylation
Subcellular location: Nucleus. Note=In punctate subnuclear structures localized adjacent to nuclear speckles, called
paraspeckles
Caution: Lacks the conserved metal-binding residues in the NUDIX motif and does not have hydrolase activity
6/11 PDB 3D structures from and Proteopedia for NUDT21 (see all 11):
2CL3 (3D)        2J8Q (3D)        3BAP (3D)        3BHO (3D)        3MDG (3D)        3MDI (3D)    
Secondary accessions: Q6IB85 Q6NE84

Explore the universe of human proteins at neXtProt for NUDT21: NX_O43809

Post-translational modifications:

  • Acetylated mainly by p300/CBP, recruited to the complex by CPSF6. Acetylation decreases interaction with PAPAO.
    • Deacetylated by the class I/II HDACs, HDAC1, HDAC3 and HDAC10, and by the class III HDACs, SIRT1 AND SIRT21
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O43809

    • NUDT21 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_008937.1  
    ENSEMBL proteins: 
     ENSP00000300291   ENSP00000454790   ENSP00000457942  
    Reactome Protein details: O43809
    Human Recombinant Protein Products: 
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    Novus Biologicals NUDT21 Proteins
    Novus Biologicals NUDT21 Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for NUDT21
    Uscn Proteins for NUDT21

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005813centrosome IDA--
    GO:0005849mRNA cleavage factor complex IDA--
    GO:0042382paraspeckles IDA15169763


    NUDT21 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for NUDT21

    Protein Domains /
    Families
    for NUDT21 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NUDT21 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015797 NUDIX_hydrolase_dom-like
     IPR016706 Cleav_polyA_spec_factor_su5
     IPR000086 NUDIX_hydrolase_dom

    Graphical View of Domain Structure for InterPro Entry O43809

    ProtoNet protein and cluster: O43809

    1 Blocks protein family: IPB000086 NUDIX hydrolase

    UniProtKB/Swiss-Prot: CPSF5_HUMAN, O43809
    Similarity: Belongs to the Nudix hydrolase family. CPSF5 subfamily
    Similarity: Contains 1 nudix hydrolase domain


    Function
    for NUDT21 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CPSF5_HUMAN, O43809
    Function: Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved
    in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds
    to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of
    two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May
    have a role in mRNA export

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NUDT21
    8/56 QIAGEN miScript miRNA Assays for microRNAs that regulate NUDT21 (see all 56):
    hsa-miR-548j hsa-miR-4272 hsa-let-7a-2* hsa-miR-548l hsa-miR-3162-5p hsa-miR-9 hsa-miR-3613-3p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: NUDT21 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NUDT21 (see all 6)
    OriGene siRNA: NUDT21
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    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT21 (see all 3)
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    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT21

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723contributes to RNA binding IDA8626397
    GO:0003729mRNA binding IDA--
    GO:0005515protein binding IPI16713569
    GO:0016787hydrolase activity IEA--
    GO:0017091AU-rich element binding IDA--


    NUDT21 for ontologies           About GeneDecksing



    Pathways & Interactions
    for NUDT21 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1RNA Polymerase II Transcription Termination
    		RNA Polymerase II Transcription Termination1.00
    		Post-Elongation Processing of Intron-Containing pre-mRNA0.79
    		Post-Elongation Processing of the Transcript1.00
    		mRNA 3'-end processing0.79
    		Cleavage of Growing Transcript in the Termination Region 1.00
    2mRNA Splicing - Major Pathway
    		mRNA Splicing1.00
    		mRNA Processing0.82
    		mRNA Splicing - Major Pathway1.00
    		mRNA processing0.48
    		Processing of Capped Intron-Containing Pre-mRNA0.96
    3Post-Elongation Processing of Intronless pre-mRNA
    		Processing of Capped Intronless Pre-mRNA1.00
    		Processing of Intronless Pre-mRNAs0.61
    		Post-Elongation Processing of Intronless pre-mRNA1.00
    4Transcription
    		Transcription1.00
    		RNA Polymerase II Transcription0.69
    5mRNA surveillance pathway
    		mRNA surveillance pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for NUDT21 
        mRNA processing

    5/15        Reactome Pathways for NUDT21 (see all 15)
        mRNA Splicing - Major Pathway
    mRNA Splicing
    RNA Polymerase II Transcription
    Transcription
    Cleavage of Growing Transcript in the Termination Region


    1         Kegg Pathway  (Kegg details for NUDT21):
        mRNA surveillance pathway


    NUDT21 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NUDT21

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/678 Interacting proteins for NUDT21 (O438091, 2, 3 ENSP000003002914) via UniProtKB, MINT, STRING, and/or I2D (see all 678)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SF3B1O755332, 3, ENSP000003353214MINT-8264523 MINT-7947479 I2D: score=2 STRING: ENSP00000335321
    CPSF6Q166302, 3, ENSP000003917744MINT-67690 I2D: score=5 STRING: ENSP00000391774
    KIAA1377Q9P2H02, 3MINT-8264402 MINT-64644 I2D: score=5 
    NIF3L1Q9GZT82, 3, ENSP000003863944MINT-66713 I2D: score=5 STRING: ENSP00000386394
    RPLP1P053862, 3MINT-64642 MINT-8264501 I2D: score=5 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--
    GO:0006378mRNA polyadenylation IMP--
    GO:0006397mRNA processing TAS--


    NUDT21 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NUDT21 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for NUDT21
    Search CenterWatch for drugs/clinical trials and news about NUDT21 / CPSF5 

    Transcripts
    for NUDT21 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NUDT21 gene: 
    NM_007006.2  

    Unigene Cluster for NUDT21:

    Nudix (nucleoside diphosphate linked moiety X)-type motif 21
    Hs.528834  [show with all ESTs]
    Unigene Representative Sequence: BX537360
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000300291(uc002eja.3) ENST00000563860 ENST00000566340 ENST00000563362
    ENST00000568822 ENST00000567110

    miRNA
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    8/56 QIAGEN miScript miRNA Assays for microRNAs that regulate NUDT21 (see all 56):
    hsa-miR-548j hsa-miR-4272 hsa-let-7a-2* hsa-miR-548l hsa-miR-3162-5p hsa-miR-9 hsa-miR-3613-3p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: NUDT21 3' UTR sequence
    Inhib. RNA
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    OriGene siRNA: NUDT21
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AJ001810.1 AK312721.1 BC001403.2 BX537360.1 BX647665.1 CR456919.1 

    13 DOTS entries:

    DT.454950  DT.100778766  DT.100760197  DT.97759798  DT.100834522  DT.312751  DT.120658042  DT.120658098 
    DT.92443296  DT.95103179  DT.120658119  DT.120658158  DT.99992090 

    24/463 AceView cDNA sequences (see all 463):

    BU629618 AI308939 BQ434343 AI687556 BQ061895 BQ027395 BF883792 AA236749 
    BI962654 AI823824 BX376138 AA831183 BU522087 AW572129 AI262831 BM717684 
    AL521226 BQ420308 CR625053 AI934702 Z43382 BM992454 BU849545 AW969035 

    GeneLoc Exon Structure


    Expression
    for NUDT21 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NUDT21 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See NUDT21 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NUDT21

    SOURCE GeneReport for Unigene cluster: Hs.528834
        SABiosciences Custom PCR Arrays for NUDT21
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    In Situ
    Assay Products:     
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    Orthologs
    for NUDT21 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NUDT21 gene from 9/36 species (see all 36)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Nudt211 , 5 nudix (nucleoside diphosphate linked moiety X)-type more1, 5 93.69(n)1
    99.56(a)1    		   8 (46.05 cM)5
    682191  NM_026623.31  NP_080899.11 
     940194035 
    chicken
    (Gallus gallus)    		 Aves LOC1008586361 cleavage and polyadenylation specificity factor subunit more 85.32(n)
    99.12(a)    		   100858636  XM_003641895.1  XP_003641943.1 
    lizard
    (Anolis carolinensis)    		 Reptilia NUDT216
    		 --
    		 98(a)
    		 1 ↔ 1
    		 GL343675.1(96214-102668)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.38932 Xenopus laevis transcribed sequence with strong similarity more 81.88(n)    CA972955.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc639662 similar to cleavage and polyadenylation specific factor more 79.43(n)   394092  BC053172.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG36891 CG3689 69.88(n)
    82.11(a)    		   39083  NM_001043132.1  NP_001036597.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea cfim-11 Protein CFIM-1 64.94(n)
    71.5(a)    		   172657  NM_059933.2  NP_492334.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT4G255501 cleavage/polyadenylation specificity factor 59.97(n)
    59.28(a)    		   828660  NM_118687.2  NP_194285.2 
    rice
    (Oryza sativa)    		 Liliopsida Os.129332 Oryza sativa (japonica cultivar-group) cDNA clone0 more 71.56(n)    AK064962.1 


    ENSEMBL Gene Tree for NUDT21 (if available)
    TreeFam Gene Tree for NUDT21 (if available) 

    Paralogs
    for NUDT21 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NUDT21 gene
    1 SIMAP similar gene for NUDT21 using alignment to 3 protein entries:     CPSF5_HUMAN (see all proteins):
    DKFZp313O211

    NUDT21 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for NUDT21
    PGOHUM00000242497 PGOHUM00000248453


    Genomic Variants
    for NUDT21 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/357 NCBI SNPs in NUDT21 are shown (see all 357)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1387272021,2
    		--56462585(+) AGATAA/CCATTG 1 -- ds50010--------
    rs1122940451,2
    		--56462686(+) TCAACG/CCTCCC 1 -- ds50011Minor allele frequency- C:0.50CSA 2
    rs1146189771,2
    		C,F,--56462710(+) AAACTC/TGGACT 1 -- ds50012Minor allele frequency- T:0.02WA EA 238
    rs1856445041,2
    		--56462718(+) ACTCAG/TTCCCC 1 -- ds50010--------
    rs754334931,2
    		C,F,--56462946(+) GCCCTC/TGGCCA 1 -- ds50014Minor allele frequency- T:0.07NA CSA EA 244
    rs763519361,2
    		C,F,--56462958(+) TCACAG/ATGACG 1 -- ds50015Minor allele frequency- A:0.06NA CSA WA EA 362
    rs1489982681,2
    		--56463159(+) TTTTAC/TACATT 1 -- ut310--------
    rs1907604121,2
    		--56463181(+) TAATAC/TCAGAA 1 -- ut310--------
    rs747682991,2
    		C--56463198(+) TCAAAA/GCCAAA 1 -- ut310--------
    rs1125873311,2
    		C--56463220(+) GCTTGA/TATACT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NUDT21 (56463045 - 56486111 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for NUDT21
         1 CNV: 4957

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    Disorders / Diseases
    for NUDT21 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NUDT21 for disorders           About GeneDecksing

    OMIM gene information: 604978    OMIM disorders: --

    2 diseases for NUDT21:    About MalaCards
    ataxia    malaria


    Export disorders for NUDT21 gene to outside databases

    Publications
    for NUDT21 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NUDT21 gene, integrated from 9 sources (see all 49):
    (articles sorted by number of sources associating them with NUDT21)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human pre-mRNA cleavage factor Im is related to spliceosomal SR proteins and can be reconstituted in vitro from recombinant subunits. (PubMed id 9659921)1, 2, 3 Rueegsegger U.... Keller W. (1998)
    2. Crystal structure of a human cleavage factor CFI(m)25/CFI(m)68/RNA complex provides an insight into poly(A) site recognition and RNA looping. (PubMed id 21295486)1, 2 Yang Q.... Doublie S. (2011)
    3. Structural basis of UGUA recognition by the Nudix protein CFI(m)25 and implications for a regulatory role in mRNA 3' processing. (PubMed id 20479262)1, 2 Yang Q.... Doublie S. (2010)
    4. Evidence that cleavage factor Im is a heterotetrameric protein complex controlling alternative polyadenylation. (PubMed id 20695905)1, 2 Kim S....Yamaguchi Y. (2010)
    5. The crystal structure of human cleavage and polyadenylation specific factor-5 reveals a dimeric Nudix protein with a conserved catalytic site. (PubMed id 18767156)1, 2 Tresaugues L....Nordlund P. (2008)
    6. Crystal structure of the 25 kDa subunit of human cleavage factor Im. (PubMed id 18445629)1, 2 Coseno M.... Doublie S. (2008)
    7. Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing. (PubMed id 17172643)1, 2 Shimazu T.... Yoshida M. (2007)
    8. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    9. Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization. (PubMed id 15169763)1, 2 Dettwiler S.... Barabino S.M. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    External Searches for NUDT21 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    Genome Databases showing NUDT21 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11051 HGNC: 13870 AceView: CPSF5 Ensembl:ENSG00000167005 euGenes: HUgn11051
    ECgene: NUDT21 Kegg: 11051 H-InvDB: NUDT21

    Other Databases showing NUDT21 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NUDT21 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NUDT21 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NUDT21 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NUDT21 gene:
    Search GeneIP for patents involving NUDT21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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