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NUDT21 Gene

protein-coding   GIFtS: 55
GCID: GC16M056463

Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif...

(Previous names: cleavage and polyadenylation specific factor 5, 25 kDa,...)
(Previous symbol: CPSF5)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 211 2     Nudix Motif 212 3
CPSF51 2 3 5     Pre-MRNA Cleavage Factor Im 25 KDa Subunit2 3
CFIM252 3 5     CPSF 25 KDa Subunit2 3
Cleavage And Polyadenylation Specific Factor 5, 25 KD Subunit1 2     Cleavage And Polyadenylation Specificity Factor Subunit 52
Cleavage And Polyadenylation Specific Factor 5, 25 KDa1 2     Pre-MRNA Cleavage Factor Im (25kD)2
Cleavage Factor Im Complex 25 KDa Subunit1 2     Pre-MRNA Cleavage Factor Im, 25kD Subunit2
Cleavage And Polyadenylation Specificity Factor 25 KDa Subunit2 3     CFIm253
Nucleoside Diphosphate-Linked Moiety X Motif 212 3     CPSF253

External Ids:    HGNC: 138701   Entrez Gene: 110512   Ensembl: ENSG000001670057   OMIM: 6049785   UniProtKB: O438093   

Export aliases for NUDT21 gene to outside databases

Previous GC identifers: GC16M055021 GC16M042333


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NUDT21 Gene:
The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and
polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the
assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. This gene
encodes the 25kD subunit of the protein complex, which is composed of four polypeptides. (provided by RefSeq, Jul
2008)

GeneCards Summary for NUDT21 Gene:
NUDT21 (nudix (nucleoside diphosphate linked moiety X)-type motif 21) is a protein-coding gene. GO annotations related to this gene include hydrolase activity and RNA binding.

UniProtKB/Swiss-Prot: CPSF5_HUMAN, O43809
Function: Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing.
Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition.
NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous
sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze
mono- and di-adenosine nucleotides. May have a role in mRNA export

Gene Wiki entry for NUDT21 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the NUDT21 gene promoter:
         AML1a   STAT5A   Nkx2-5   E47   GATA-1   AREB6   GATA-6   CP2   HFH-1   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNUDT21 promoter sequence
   Search Chromatin IP Primers for NUDT21

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NUDT21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q12.2   Ensembl cytogenetic band:  16q12.2   HGNC cytogenetic band: 16q12.2

NUDT21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUDT21 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M056463:  view genomic region     (about GC identifiers)

Start:
56,463,045 bp from pter      End:
56,486,111 bp from pter
Size:
23,067 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CPSF5_HUMAN, O43809 (See protein sequence)
Recommended Name: Cleavage and polyadenylation specificity factor subunit 5  
Size: 227 amino acids; 26227 Da
Subunit: Homodimer. Component of the cleavage factor Im (CFIm) complex, composed of, at least, NUDT21/CPSF5 and
CPSF6 or CPSF7. Within the cleavage factor Im complex, the NUDT21/CPSF5 homodimer is at the core of a
heterotetramer, and is clasped by two additional subunits (CPSF6 or CPSF7). Interacts with CPSF6, CPSF7, PABPN1
and SNRNP70. Interacts with PAPOLA; the interaction is diminished by acetylation
Caution: Lacks the conserved metal-binding residues in the NUDIX motif and does not have hydrolase activity
Selected PDB 3D structures from and Proteopedia for NUDT21 (see all 11):
2CL3 (3D)        2J8Q (3D)        3BAP (3D)        3BHO (3D)        3MDG (3D)        3MDI (3D)    
Secondary accessions: Q6IB85 Q6NE84

Explore the universe of human proteins at neXtProt for NUDT21: NX_O43809

Explore proteomics data for NUDT21 at MOPED

Post-translational modifications: 

  • Acetylated mainly by p300/CBP, recruited to the complex by CPSF6. Acetylation decreases interaction with PAPAO.
    Deacetylated by the class I/II HDACs, HDAC1, HDAC3 and HDAC10, and by the class III HDACs, SIRT1 AND SIRT21
  • Ubiquitination2 at Lys23, Lys29, Lys56, Lys182
  • Modification sites at PhosphoSitePlus

  • See NUDT21 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_008937.1  
    ENSEMBL proteins: 
     ENSP00000300291   ENSP00000454790   ENSP00000457942  
    Reactome Protein details: O43809

    NUDT21 Human Recombinant Protein Products:

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    ProSpec Recombinant Protein for NUDT21
    Cloud-Clone Corp. Proteins for NUDT21

     
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    NUDT21 Antibody Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NUDT: Nudix motif containing

    3 InterPro protein domains:
     IPR015797 NUDIX_hydrolase_dom-like
     IPR016706 Cleav_polyA_spec_factor_su5
     IPR000086 NUDIX_hydrolase_dom

    Graphical View of Domain Structure for InterPro Entry O43809

    ProtoNet protein and cluster: O43809

    1 Blocks protein domain: IPB000086 NUDIX hydrolase

    UniProtKB/Swiss-Prot: CPSF5_HUMAN, O43809
    Similarity: Belongs to the Nudix hydrolase family. CPSF5 subfamily
    Similarity: Contains 1 nudix hydrolase domain


    Find genes that share domains with NUDT21           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CPSF5_HUMAN, O43809
    Function: Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing.
    Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition.
    NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous
    sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze
    mono- and di-adenosine nucleotides. May have a role in mRNA export

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723contributes to RNA binding IDA8626397
    GO:0003729mRNA binding IDA--
    GO:0005515protein binding IPI11716503
    GO:0016787hydrolase activity IEA--
    GO:0017091AU-rich element binding IDA--
         
    Find genes that share ontologies with NUDT21           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NUDT21
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    miRNA
    Products:
        
    miRTarBase miRNAs that target NUDT21:
    hsa-mir-20a-5p (MIRT050609), hsa-mir-320a (MIRT044405), hsa-mir-375 (MIRT020022), hsa-mir-1296-5p (MIRT036074), hsa-let-7c-5p (MIRT051764)

    Block miRNA regulation of human, mouse, rat NUDT21 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NUDT21 (see all 56):
    hsa-miR-548j hsa-miR-4272 hsa-let-7a-2* hsa-miR-548l hsa-miR-3162-5p hsa-miR-9 hsa-miR-3613-3p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidNUDT21 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for NUDT21
    Predesigned siRNA for gene silencing in human, mouse, rat NUDT21

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: NUDT21 (NM_007006)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUDT21
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUDT21

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT21


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CPSF5_HUMAN, O43809: Nucleus. Note=In punctate subnuclear structures localized adjacent to nuclear speckles,
    called paraspeckles
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    mitochondrion2
    cytosol1
    endoplasmic reticulum1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005813centrosome IDA--
    GO:0005849mRNA cleavage factor complex IDA--
    GO:0042382paraspeckles IDA15169763

    Find genes that share ontologies with NUDT21           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NUDT21 About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA processing0.44
    2RNA Polymerase II Transcription Termination
    RNA Polymerase II Transcription Termination0.80
    Processing of Capped Intronless Pre-mRNA0.52
    Cleavage of Growing Transcript in the Termination Region0.80
    Processing of Intronless Pre-mRNAs0.00
    mRNA 3-end processing0.80
    3Formation of RNA Pol II elongation complex
    RNA Polymerase II Transcription0.60
    4Gene Expression
    Gene Expression0.40
    5mRNA surveillance pathway
    mRNA surveillance pathway


    Find genes that share SuperPaths with NUDT21           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for NUDT21
        mRNA processing

    4 Reactome Pathways for NUDT21
        mRNA Splicing - Major Pathway
    mRNA 3'-end processing
    Processing of Intronless Pre-mRNAs
    Cleavage of Growing Transcript in the Termination Region


    1 Kegg Pathway  (Kegg details for NUDT21):
        mRNA surveillance pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NUDT21
    Interactions:

        Search GeneGlobe Interaction Network for NUDT21

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NUDT21 (O438091, 2, 3 ENSP000003002914) via UniProtKB, MINT, STRING, and/or I2D (see all 729)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CPSF6Q166301, 2, 3, ENSP000003917744EBI-355720,EBI-358410 MINT-8414090 MINT-8413995 MINT-67690 MINT-8414037 MINT-8414025 I2D: score=5 STRING: ENSP00000391774
    ENSG00000206289P287022, 3MINT-7947479 I2D: score=1 
    ENSG00000227322P287022, 3MINT-7947479 I2D: score=1 
    ENSG00000228333P287022, 3MINT-7947479 I2D: score=1 
    ENSG00000231321P287022, 3MINT-7947479 I2D: score=1 
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    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--
    GO:0006378mRNA polyadenylation IMP--
    GO:0006397mRNA processing IDA8626397

    Find genes that share ontologies with NUDT21           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NUDT21 (CPSF5)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NUDT21 gene: 
    NM_007006.2  

    Unigene Cluster for NUDT21:

    Nudix (nucleoside diphosphate linked moiety X)-type motif 21
    Hs.528834  [show with all ESTs]
    Unigene Representative Sequence: BX537360
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000300291(uc002eja.3) ENST00000563860 ENST00000566340 ENST00000563362
    ENST00000568822 ENST00000567110
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NUDT21 (see all 56):
    hsa-miR-548j hsa-miR-4272 hsa-let-7a-2* hsa-miR-548l hsa-miR-3162-5p hsa-miR-9 hsa-miR-3613-3p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidNUDT21 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: NUDT21 (NM_007006)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUDT21
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat NUDT21
      QuantiFast Probe-based Assays in human, mouse, rat NUDT21

    Additional mRNA sequence: 

    AJ001810.1 AK312721.1 BC001403.2 BX537360.1 BX647665.1 CR456919.1 

    13 DOTS entries:

    DT.454950  DT.100778766  DT.100760197  DT.97759798  DT.100834522  DT.312751  DT.120658042  DT.120658098 
    DT.92443296  DT.95103179  DT.120658119  DT.120658158  DT.99992090 

    Selected AceView cDNA sequences (see all 463):

    CB133793 BM791853 AA678799 BQ009156 BQ026957 BG753954 BQ233144 AI687556 
    BQ027395 BF793042 BU157763 BM992454 BQ574754 BU849545 CK821226 AW969035 
    AL138394 CA306734 H89674 BU428996 BM674885 BQ944195 AL521226 BX510232 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NUDT21 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NUDT21 Expression
    About this image


    NUDT21 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Thymus (Hematopoietic System)
             Thymus
     
     Kidney (Urinary System)
             Metanephros
    NUDT21 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NUDT21 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.528834
        Custom PCR Arrays for NUDT21
    Primer
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    OriGene qPCR primer pairs and template standards for NUDT21
    OriGene qSTAR qPCR primer pairs in human, mouse for NUDT21
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    QuantiTect SYBR Green Assays in human, mouse, rat NUDT21
    QuantiFast Probe-based Assays in human, mouse, rat NUDT21
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT21

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NUDT21 gene from Selected species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nudt211 , 5 nudix (nucleoside diphosphate linked moiety X)-type more1, 5 93.69(n)1
    99.56(a)1
      8 (46.05 cM)5
    682191  NM_026623.31  NP_080899.11 
     940194035 
    chicken
    (Gallus gallus)
    Aves NUDT211 nudix (nucleoside diphosphate linked moiety X)-type more 85.32(n)
    99.12(a)
      100858636  NM_001277674.1  NP_001264603.1 
    lizard
    (Anolis carolinensis)
    Reptilia NUDT216
    nudix (nucleoside diphosphate linked moiety X)-typ...
    98(a)
    1 ↔ 1
    GL343675.1(95464-103025)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.38932 Xenopus laevis transcribed sequence with strong similarity more 81.88(n)    CA972955.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc639662 similar to cleavage and polyadenylation specific factor more 79.43(n)   394092  BC053172.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG36891 CG3689 70.03(n)
    82.11(a)
      39083  NM_001043132.2  NP_001036597.1 
    worm
    (Caenorhabditis elegans)
    Secernentea cfim-11 cfim-1 64.94(n)
    71.5(a)
      172657  NM_059933.3  NP_492334.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G255501 AT4G25550 59.97(n)
    59.28(a)
      828660  NM_118687.2  NP_194285.2 
    rice
    (Oryza sativa)
    Liliopsida Os.129332 Oryza sativa (japonica cultivar-group) cDNA clone0 more 71.56(n)    AK064962.1 


    ENSEMBL Gene Tree for NUDT21 (if available)
    TreeFam Gene Tree for NUDT21 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NUDT21 gene
    1 SIMAP similar gene for NUDT21 using alignment to 3 protein entries:     CPSF5_HUMAN (see all proteins):
    DKFZp313O211

    Find genes that share paralogs with NUDT21           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for NUDT21
    PGOHUM00000242497 PGOHUM00000248453


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NUDT21 (see all 354)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1387272021,2
    --56462585(+) AGATAA/CCATTG 1 -- ds50010--------
    rs1122940451,2
    C,F--56462686(+) TCAACG/CCTCCC 1 -- ds50011Minor allele frequency- C:0.50CSA 2
    rs1146189771,2
    C,F--56462710(+) AAACTC/TGGACT 1 -- ds50012Minor allele frequency- T:0.02WA EA 238
    rs1856445041,2
    --56462718(+) ACTCAG/TTCCCC 1 -- ds50010--------
    rs754334931,2
    C,F--56462946(+) GCCCTC/TGGCCA 1 -- ds50014Minor allele frequency- T:0.07NA CSA EA 244
    rs763519361,2
    C,F--56462958(+) TCACAG/ATGACG 1 -- ds50015Minor allele frequency- A:0.06NA CSA WA EA 362
    rs1489982681,2
    --56463159(+) TTTTAC/TACATT 1 -- ut310--------
    rs1907604121,2
    --56463181(+) TAATAC/TCAGAA 1 -- ut310--------
    rs747682991,2
    C--56463198(+) TCAAAA/GCCAAA 1 -- ut310--------
    rs1125873311,2
    C--56463220(+) GCTTGA/TATACT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NUDT21 (56463045 - 56486111 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NUDT21:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833242CNV Loss17160897
    nsv833243CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NUDT21
    DNA2.0 Custom Variant and Variant Library Synthesis for NUDT21

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604978    OMIM disorders: --


    Find genes that share disorders with NUDT21           About GenesLikeMe


    Export disorders for NUDT21 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NUDT21 gene, integrated from 10 sources (see all 57):
    (articles sorted by number of sources associating them with NUDT21)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human pre-mRNA cleavage factor Im is related to spliceosomal SR proteins and can be reconstituted in vitro from recombinant subunits. (PubMed id 9659921)1, 2, 3 Rueegsegger U.... Keller W. (Mol. Cell 1998)
    2. Crystal structure of a human cleavage factor CFI(m)25/CFI(m)68/RNA complex provides an insight into poly(A) site recognition and RNA looping. (PubMed id 21295486)1, 2 Yang Q.... Doublie S. (Structure 2011)
    3. Structural basis of UGUA recognition by the Nudix protein CFI(m)25 and implications for a regulatory role in mRNA 3' processing. (PubMed id 20479262)1, 2 Yang Q.... Doublie S. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    4. Evidence that cleavage factor Im is a heterotetrameric protein complex controlling alternative polyadenylation. (PubMed id 20695905)1, 2 Kim S....Yamaguchi Y. (Genes Cells 2010)
    5. The crystal structure of human cleavage and polyadenylation specific factor-5 reveals a dimeric Nudix protein with a conserved catalytic site. (PubMed id 18767156)1, 2 Tresaugues L.... Nordlund P. (Proteins 2008)
    6. Crystal structure of the 25 kDa subunit of human cleavage factor Im. (PubMed id 18445629)1, 2 Coseno M.... Doublie S. (Nucleic Acids Res. 2008)
    7. Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing. (PubMed id 17172643)1, 2 Shimazu T.... Yoshida M. (J. Biol. Chem. 2007)
    8. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    9. Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization. (PubMed id 15169763)1, 2 Dettwiler S.... Barabino S.M. (J. Biol. Chem. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11051 HGNC: 13870 AceView: CPSF5 Ensembl:ENSG00000167005 euGenes: HUgn11051
    ECgene: NUDT21 Kegg: 11051 H-InvDB: NUDT21

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NUDT21 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NUDT21 gene:
    Search GeneIP for patents involving NUDT21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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