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Aliases for NUDT21 Gene

Aliases for NUDT21 Gene

  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 21 2 3
  • CFIM25 3 4 6
  • CPSF5 3 4 6
  • Cleavage And Polyadenylation Specificity Factor 25 KDa Subunit 3 4
  • Cleavage And Polyadenylation Specific Factor 5, 25 KD Subunit 2 3
  • Cleavage And Polyadenylation Specific Factor 5, 25 KDa 2 3
  • Nucleoside Diphosphate-Linked Moiety X Motif 21 3 4
  • Pre-MRNA Cleavage Factor Im 25 KDa Subunit 3 4
  • Cleavage Factor Im Complex 25 KDa Subunit 2 3
  • CPSF 25 KDa Subunit 3 4
  • Nudix Motif 21 3 4
  • Cleavage And Polyadenylation Specificity Factor Subunit 5 3
  • Pre-MRNA Cleavage Factor Im, 25kD Subunit 3
  • Pre-MRNA Cleavage Factor Im (25kD) 3
  • CPSF25 4

External Ids for NUDT21 Gene

Previous Symbols for NUDT21 Gene

  • CPSF5

Summaries for NUDT21 Gene

Entrez Gene Summary for NUDT21 Gene

  • The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. This gene encodes the 25kD subunit of the protein complex, which is composed of four polypeptides. [provided by RefSeq, Jul 2008]

GeneCards Summary for NUDT21 Gene

NUDT21 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 21) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. GO annotations related to this gene include RNA binding and hydrolase activity.

UniProtKB/Swiss-Prot for NUDT21 Gene

  • Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5-UGUA-3 elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export.

Gene Wiki entry for NUDT21 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT21 Gene

Genomics for NUDT21 Gene

Genomic Location for NUDT21 Gene

Start:
56,429,133 bp from pter
End:
56,452,199 bp from pter
Size:
23,067 bases
Orientation:
Minus strand

Genomic View for NUDT21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUDT21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT21 Gene

Regulatory Elements for NUDT21 Gene

Proteins for NUDT21 Gene

  • Protein details for NUDT21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43809-CPSF5_HUMAN
    Recommended name:
    Cleavage and polyadenylation specificity factor subunit 5
    Protein Accession:
    O43809
    Secondary Accessions:
    • Q6IB85
    • Q6NE84

    Protein attributes for NUDT21 Gene

    Size:
    227 amino acids
    Molecular mass:
    26227 Da
    Quaternary structure:
    • Homodimer. Component of the cleavage factor Im (CFIm) complex, composed of, at least, NUDT21/CPSF5 and CPSF6 or CPSF7. Within the cleavage factor Im complex, the NUDT21/CPSF5 homodimer is at the core of a heterotetramer, and is clasped by two additional subunits (CPSF6 or CPSF7). Interacts with CPSF6, CPSF7, PABPN1 and SNRNP70. Interacts with PAPOLA; the interaction is diminished by acetylation.

    Three dimensional structures from OCA and Proteopedia for NUDT21 Gene

neXtProt entry for NUDT21 Gene

Proteomics data for NUDT21 Gene at MOPED

Post-translational modifications for NUDT21 Gene

  • Acetylated mainly by p300/CBP, recruited to the complex by CPSF6. Acetylation decreases interaction with PAPAO. Deacetylated by the class I/II HDACs, HDAC1, HDAC3 and HDAC10, and by the class III HDACs, SIRT1 AND SIRT2.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys23, Lys29, Lys56, and Lys182

Other Protein References for NUDT21 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NUDT21 Gene

Domains for NUDT21 Gene

Gene Families for NUDT21 Gene

HGNC:
  • NUDT :Nudix motif containing

Protein Domains for NUDT21 Gene

UniProtKB/Swiss-Prot:

CPSF5_HUMAN
Domain:
  • Contains 1 nudix hydrolase domain.:
    • O43809
Family:
  • Belongs to the Nudix hydrolase family. CPSF5 subfamily.:
    • O43809
genes like me logo Genes that share domains with NUDT21: view

Function for NUDT21 Gene

Molecular function for NUDT21 Gene

UniProtKB/Swiss-Prot Function: Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5-UGUA-3 elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export.

Gene Ontology (GO) - Molecular Function for NUDT21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 contributes_to RNA binding IDA 8626397
GO:0003729 mRNA binding IDA 21295486
GO:0005515 protein binding IPI 11716503
GO:0016787 hydrolase activity IEA --
GO:0017091 AU-rich element binding IDA 20479262
genes like me logo Genes that share ontologies with NUDT21: view

miRNA for NUDT21 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NUDT21 Gene

Localization for NUDT21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDT21 Gene

Nucleus. Note=In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUDT21 Gene COMPARTMENTS Subcellular localization image for NUDT21 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
mitochondrion 2
cytosol 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for NUDT21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 20695905
GO:0005654 nucleoplasm TAS --
GO:0005813 centrosome IDA --
GO:0005849 mRNA cleavage factor complex IDA 20695905
GO:0042382 paraspeckles IDA 15169763
genes like me logo Genes that share ontologies with NUDT21: view

Pathways for NUDT21 Gene

genes like me logo Genes that share pathways with NUDT21: view

Gene Ontology (GO) - Biological Process for NUDT21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006378 mRNA polyadenylation IMP 20695905
GO:0006397 mRNA processing IDA 8626397
genes like me logo Genes that share ontologies with NUDT21: view

Transcripts for NUDT21 Gene

Unigene Clusters for NUDT21 Gene

Nudix (nucleoside diphosphate linked moiety X)-type motif 21:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT21 Gene

No ASD Table

Relevant External Links for NUDT21 Gene

GeneLoc Exon Structure for
NUDT21
ECgene alternative splicing isoforms for
NUDT21

Expression for NUDT21 Gene

mRNA expression in normal human tissues for NUDT21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUDT21 Gene

SOURCE GeneReport for Unigene cluster for NUDT21 Gene Hs.528834

genes like me logo Genes that share expressions with NUDT21: view

Orthologs for NUDT21 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUDT21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUDT21 36
  • 99.85 (n)
  • 100 (a)
NUDT21 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NUDT21 36
  • 94.42 (n)
  • 100 (a)
NUDT21 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUDT21 36
  • 95.3 (n)
  • 99.56 (a)
NUDT21 37
  • 60 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nudt21 36
  • 93.69 (n)
  • 99.56 (a)
Nudt21 16
Nudt21 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NUDT21 37
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUDT21 37
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nudt21 36
  • 92.07 (n)
  • 99.56 (a)
chicken
(Gallus gallus)
Aves NUDT21 36
  • 85.32 (n)
  • 99.12 (a)
NUDT21 37
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUDT21 37
  • 98 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3893 36
tropical clawed frog
(Silurana tropicalis)
Amphibia nudt21 36
  • 81.35 (n)
  • 98.68 (a)
Str.6398 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8490 36
zebrafish
(Danio rerio)
Actinopterygii cpsf5 36
  • 79.15 (n)
  • 97.8 (a)
cpsf5 37
  • 97 (a)
OneToOne
zgc63966 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007242 36
  • 67.41 (n)
  • 79.91 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3689 36
  • 70.03 (n)
  • 82.11 (a)
CG3689 37
  • 76 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cfim-1 36
  • 64.94 (n)
  • 71.5 (a)
cfim-1 37
  • 63 (a)
OneToOne
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.8939 36
soybean
(Glycine max)
eudicotyledons Gma.4672 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G25550 36
  • 59.97 (n)
  • 59.28 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.9029 36
corn
(Zea mays)
Liliopsida Zm.4316 36
rice
(Oryza sativa)
Liliopsida Os.12933 36
Os04g0683100 36
  • 58.96 (n)
  • 56.13 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.7293 36
bread mold
(Neurospora crassa)
Ascomycetes NCU09014 36
  • 54.5 (n)
  • 54.03 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13848 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4504 37
  • 76 (a)
OneToOne
Species with no ortholog for NUDT21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for NUDT21 Gene

ENSEMBL:
Gene Tree for NUDT21 (if available)
TreeFam:
Gene Tree for NUDT21 (if available)

Paralogs for NUDT21 Gene

Selected SIMAP similar genes for NUDT21 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for NUDT21 Gene

genes like me logo Genes that share paralogs with NUDT21: view

No data available for Paralogs for NUDT21 Gene

Variants for NUDT21 Gene

Sequence variations from dbSNP and Humsavar for NUDT21 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs4533280 -- 56,445,386(+) AATGG(A/G)ATATC intron-variant
rs4784668 -- 56,441,157(+) gcccc(A/G)caaag intron-variant
rs4784669 -- 56,447,370(+) GTTAC(A/G)GATCA intron-variant
rs7186820 -- 56,433,207(+) ATACT(C/G)AATAA intron-variant
rs7187714 -- 56,433,352(+) ACAGA(A/T)GAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUDT21 Gene

Variant ID Type Subtype PubMed ID
nsv833242 CNV Loss 17160897
nsv833243 CNV Gain 17160897

Relevant External Links for NUDT21 Gene

HapMap Linkage Disequilibrium report
NUDT21

Disorders for NUDT21 Gene

No disorders were found for NUDT21 Gene.

No data available for UniProtKB/Swiss-Prot for NUDT21 Gene

Publications for NUDT21 Gene

  1. Human pre-mRNA cleavage factor Im is related to spliceosomal SR proteins and can be reconstituted in vitro from recombinant subunits. (PMID: 9659921) Rueegsegger U. … Keller W. (Mol. Cell 1998) 2 3 4
  2. Association of polyadenylation cleavage factor I with U1 snRNP. (PMID: 14561889) Awasthi S. … Alwine J.C. (RNA 2003) 3 4
  3. A mechanism for the regulation of pre-mRNA 3' processing by human cleavage factor Im. (PMID: 14690600) Brown K.M. … Gilmartin G.M. (Mol. Cell 2003) 3 4
  4. Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization. (PMID: 15169763) Dettwiler S. … Barabino S.M. (J. Biol. Chem. 2004) 3 4
  5. Knock-down of 25 kDa subunit of cleavage factor Im in Hela cells alters alternative polyadenylation within 3'-UTRs. (PMID: 17098938) Kubo T. … Handa H. (Nucleic Acids Res. 2006) 3 23

Products for NUDT21 Gene

Sources for NUDT21 Gene

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