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NUDT2 Gene

protein-coding   GIFtS: 57
GCID: GC09P034329

Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif...


(Previous symbol: APAH1)
  See NUDT2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 21 2     Nudix Motif 22 3
APAH11 2 3 5     EC 3.6.1.173 8
Ap4Aase1 2 3     5''-P11
Diadenosine Tetraphosphatase1 2 3     Diadenosine 5'1
Ap4A Hydrolase 11 2     P4-Tetraphosphate Pyrophosphohydrolase1
Bis(5'-Nucleosyl)-Tetraphosphatase (Asymmetrical)1 2     Bis(5'-Nucleosyl)-Tetraphosphatase [Asymmetrical]2
Diadenosine 5',5'''-P1,P4-Tetraphosphate Asymmetrical Hydrolase2 3     Diadenosine 5',5''-P1,P4-Tetraphosphate Pyrophosphohydrolase2
Nucleoside Diphosphate-Linked Moiety X Motif 22 3     Ap4A Hydrolase3

External Ids:    HGNC: 80491   Entrez Gene: 3182   Ensembl: ENSG000001649787   OMIM: 6028525   UniProtKB: P505833   

Export aliases for NUDT2 gene to outside databases

Previous GC identifers: GC09P034641 GC09P034499 GC09P034319 GC09P034284


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NUDT2 Gene:
This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX
hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain
nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible
for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be
established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this
locus and four transcript variants, all encoding the same protein, have been identified. (provided by RefSeq, Sep
2011)

GeneCards Summary for NUDT2 Gene:
NUDT2 (nudix (nucleoside diphosphate linked moiety X)-type motif 2) is a protein-coding gene. Diseases associated with NUDT2 include cartilage-hair hypoplasia. GO annotations related to this gene include bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity and GTP binding.

UniProtKB/Swiss-Prot: AP4A_HUMAN, P50583
Function: Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis

Gene Wiki entry for NUDT2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the NUDT2 gene promoter:
         GR   GR-beta   HNF-1A   Egr-4   FOXC1   HNF-1   HFH-1   GR-alpha   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): NUDT2 promoter sequence
   Search Chromatin IP Primers for NUDT2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NUDT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p13

NUDT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUDT2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P034329:  view genomic region     (about GC identifiers)

Start:
34,329,504 bp from pter      End:
34,343,709 bp from pter
Size:
14,206 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: AP4A_HUMAN, P50583 (See protein sequence)
Recommended Name: Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]  
Size: 147 amino acids; 16829 Da
Cofactor: Divalent ions (By similarity)
6 PDB 3D structures from and Proteopedia for NUDT2:
1XSA (3D)        1XSB (3D)        1XSC (3D)        3U53 (3D)        4ICK (3D)        4IJX (3D)    
Secondary accessions: D3DRM0 Q5T589

Explore the universe of human proteins at neXtProt for NUDT2: NX_P50583

Explore proteomics data for NUDT2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for NUDT2 (P50583) (see all 5)
     EHQAYRWL  IEFLLLQAS  TALRETQEE  LQEGHQFLCS 


    See NUDT2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001152.1  NP_001231319.1  NP_671701.1  NP_671702.1  

    ENSEMBL proteins: 
     ENSP00000368455   ENSP00000344187   ENSP00000368452  

    NUDT2 Human Recombinant Protein Products:

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    Sino Biological Recombinant Protein for NUDT2
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    ProSpec Recombinant Protein for NUDT2
    Cloud-Clone Corp. Proteins for NUDT2

     
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    antibodies-online proteins for NUDT2 (4 products) 

     
    antibodies-online peptides for NUDT2

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    antibodies-online antibodies for NUDT2 (32 products) 

    NUDT2 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NUDT: Nudix motif containing

    4 InterPro protein domains:
     IPR015797 NUDIX_hydrolase_dom-like
     IPR020084 NUDIX_hydrolase_CS
     IPR000086 NUDIX_hydrolase_dom
     IPR003565 Tetra_PHTase

    Graphical View of Domain Structure for InterPro Entry P50583

    ProtoNet protein and cluster: P50583

    2 Blocks protein domains:
    IPB000086 NUDIX hydrolase
    IPB003565 Bis(5'-nucleosyl)-tetraphosphatase signature


    UniProtKB/Swiss-Prot: AP4A_HUMAN, P50583
    Similarity: Belongs to the Nudix hydrolase family
    Similarity: Contains 1 nudix hydrolase domain


    Find genes that share domains with NUDT2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AP4A_HUMAN, P50583
    Function: Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis
    Catalytic activity: P(1),P(4)-bis(5'-guanosyl) tetraphosphate + H(2)O = GTP + GMP

         Genatlas biochemistry entry for NUDT2:
    nudix (nucleoside diphosphate linked moiety X)-type motif 2,hydrolase,putative mouse cleaning gene whose functions
    is to cleanse the cell of potentially deleterious endogenous metabolites and to modulate the accumulation of
    intermediates in biochemical pathways

         Enzyme Number (IUBMB): EC 3.6.1.171 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004081bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity ISS11738085
    GO:0005525GTP binding IEA--
    GO:0008803bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity TAS7487923
    GO:0016787hydrolase activity ----
         
    Find genes that share ontologies with NUDT2           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for NUDT2

    miRNA
    Products:
        
    miRTarBase miRNAs that target NUDT2:
    hsa-mir-423-3p (MIRT042526), hsa-mir-744-5p (MIRT037637)

    Block miRNA regulation of human, mouse, rat NUDT2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate NUDT2:
    hsa-miR-142-5p hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidNUDT2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat NUDT2

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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUDT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUDT2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    mitochondrion2
    extracellular1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--

    Find genes that share ontologies with NUDT2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NUDT2 About    
    See pathways by source

    SuperPathContained pathways About
    1Purine metabolism (KEGG)
    Purine metabolism0.38
    Pyrimidine metabolism0.38


    Find genes that share SuperPaths with NUDT2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    2 Kegg Pathways  (Kegg details for NUDT2):
        Purine metabolism
    Pyrimidine metabolism

        Pathway & Disease-focused RT2 Profiler PCR Array including NUDT2: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for NUDT2

    1 Interacting protein for NUDT2 (P505833) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GAPDHP044063I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006139nucleobase-containing compound metabolic process TAS7487923
    GO:0006915apoptotic process ISS10452553

    Find genes that share ontologies with NUDT2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NUDT2 (AP4A)

    Selected HMDB Compounds for NUDT2 (see all 13)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Diadenosine tetraphosphateDiadenosine 5',5'''-P1,P4-tetraphosphate (see all 6)5542-28-9--
    Diguanosine tetraphosphate(ppG)2 (see all 9)4130-19-2--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    P1,P4-Bis(5'-uridyl) tetraphosphateUppppU ----
    P1,P4-Bis(5'-xanthosyl) tetraphosphateXppppX (see all 2)----
    Uridine 5'-monophosphate5'-UMP (see all 12)58-97-9--
    Uridine triphosphate5'-UTP (see all 7)63-39-8--

    2 Novoseek inferred chemical compound relationships for NUDT2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    diadenosine tetraphosphate 86.1 1 20144233 (1)
    atp 48.8 1 15772762 (1)



    Find genes that share compounds with NUDT2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NUDT2 gene (4 alternative transcripts): 
    NM_001161.4  NM_001244390.1  NM_147172.2  NM_147173.2  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379158(uc003zub.3) ENST00000346365(uc003zud.3 uc022bga.1)
    ENST00000379155(uc003zuc.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat NUDT2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate NUDT2:
    hsa-miR-142-5p hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidNUDT2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NUDT2
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    Primer
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    OriGene qPCR primer pairs and template standards for NUDT2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NUDT2
      QuantiTect SYBR Green Assays in human, mouse, rat NUDT2
      QuantiFast Probe-based Assays in human, mouse, rat NUDT2

    Selected AceView cDNA sequences (see all 154):

    T24918 AW292786 BM818895 AI339040 AI381724 BF433119 BQ647440 BQ961312 
    BM784602 T35530 BM831018 F21141 BM681712 AI199417 BU689686 BU786517 
    BU739666 BQ007098 AA806464 NM_001161 CB305496 AA310093 AI264346 BM719797 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for NUDT2    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e
    SP1:                          -                                                   
    SP2:                          -     -                                             
    SP3:                                                                              
    SP4:                          -     -     -                                       
    SP5:                          -     -     -     -                                 


    ECgene alternative splicing isoforms for NUDT2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NUDT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAGCCAAGA
    NUDT2 Expression
    About this image


    NUDT2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 14 entries
             Thalamus
             Olfactory Bulb   
     
     Heart (Cardiovascular System)
     
     Larynx (Respiratory System)
    NUDT2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NUDT2 Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Array including NUDT2: 
              Apoptosis 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NUDT2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nudt21 , 5 nudix (nucleoside diphosphate linked moiety X)-type more1, 5 89.57(n)1
    89.12(a)1
      4 (21.65 cM)5
    664011  NM_025539.21  NP_079815.21 
     414651515 
    chicken
    (Gallus gallus)
    Aves NUDT21 nudix (nucleoside diphosphate linked moiety X)-type more 67.59(n)
    62.5(a)
      427399  XM_424973.4  XP_424973.1 
    lizard
    (Anolis carolinensis)
    Reptilia NUDT26
    nudix (nucleoside diphosphate linked moiety X)-typ...
    65(a)
    1 ↔ 1
    GL343372.1(1029189-1030911)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.15632 Transcribed sequence with weak similarity to protein more 78.15(n)    137726250 
    zebrafish
    (Danio rerio)
    Actinopterygii nudt21 nudix (nucleoside diphosphate linked moiety X)-type more 62.35(n)
    59.71(a)
      436595  NM_001002323.1  NP_001002323.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Apf1 diadenosine tetraphosphate hydrolase 57.39(n)
    48.87(a)
      318908  NM_164880.3  NP_723505.2 
    worm
    (Caenorhabditis elegans)
    Secernentea ndx-41 ndx-4 55.31(n)
    50.72(a)
      189639  NM_061012.4  NP_493413.1 


    ENSEMBL Gene Tree for NUDT2 (if available)
    TreeFam Gene Tree for NUDT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NUDT2 (see all 258)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1808696601,2
    --34331330(+) TCAGAC/TCCTCT 4 -- int10--------
    rs1512248221,2
    C--34331376(+) AAAGTA/GGGTGT 4 -- int10--------
    rs172598171,2
    C,F--34331466(+) CTGACT/GGCATA 4 -- int17Minor allele frequency- G:0.05NA 268
    rs1391302941,2
    --34331519(+) AATGCC/TTGGAA 4 -- int10--------
    rs1865603001,2
    --34331582(+) GGAATA/GTGAGC 4 -- int10--------
    rs1919911961,2
    --34331590(+) AGCTGC/TAGAGG 4 -- int10--------
    rs727331251,2
    C--34331672(+) AAAAAA/GATTGT 4 -- int13Minor allele frequency- G:0.13NA EA 242
    rs1838624491,2
    --34331688(+) TAAAAA/GTAATT 4 -- int10--------
    rs1884577251,2
    --34331839(+) CACCCC/GCTCCT 4 -- int10--------
    rs557081431,2
    C--34331880(+) CTTTCC/TCTTGG 4 -- int14Minor allele frequency- T:0.09NA WA EA 360

    HapMap Linkage Disequilibrium report for NUDT2 (34329504 - 34343709 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for NUDT2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2738388CNV Deletion23290073
    esv2738387CNV Deletion23290073
    nsv831542CNV Gain17160897
    nsv893037CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NUDT2
    DNA2.0 Custom Variant and Variant Library Synthesis for NUDT2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602852    OMIM disorders: --

    1 disease for NUDT2:    
    About MalaCards
    cartilage-hair hypoplasia

    1 disease from the University of Copenhagen DISEASES database for NUDT2:
    cartilage-hair hypoplasia

    Find genes that share disorders with NUDT2           About GenesLikeMe

    Genetic Association Database (GAD): NUDT2
    Human Genome Epidemiology (HuGE) Navigator: NUDT2 (1 document)

    Export disorders for NUDT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NUDT2 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with NUDT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human diadenosine 5',5''-P1,P4-tetraphosphate pyrophosphohydrolase is a member of the MutT family of nucleotide pyrophosphatases. (PubMed id 7487923)1, 2, 3 Thorne N.M.H....McLennan A.G. (Biochem. J. 1995)
    2. Chromosomal localization of the human diadenosine 5',5&quot;'-P1,P4-tetraphosphate pyrophosphohydrolase (Ap4A hydrolase) gene (APAH1) to 9p13. (PubMed id 9479504)1, 3, 9 McLennan A.G....RidanpAoAo M. (Genomics 1998)
    3. Structure and substrate-binding mechanism of human Ap4A hydrolase. (PubMed id 15596429)1, 2, 9 Swarbrick J.D....Gooley P.R. (J. Biol. Chem. 2005)
    4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. SARS coronavirus protein 7a interacts with human Ap4A-hydrolase. (PubMed id 20144233)1, 9 Vasilenko N....Zakhartchouk A. (Virol. J. 2010)
    7. Diadenosine 5',5&quot;'-P1,P4-tetraphosphate hydrolase is present in human erythrocytes, leukocytes and platelets. (PubMed id 7767787)1, 9 Hankin S....McLennan A.G. (amp 1995)
    8. 1H, 13C, and 15N resonance assignments of the 17 kDa Ap4A hydrolase from Homo sapiens in the presence and absence of ATP. (PubMed id 15772762)1, 9 Swarbrick J.D....Gooley P.R. (J. Biomol. NMR 2005)
    9. Metabolic transformation of AZTp4A by Ap4A hydrolase regenerates AZT triphosphate. (PubMed id 12767470)1, 9 Pitcher W.H....London R.E. (Antiviral Res. 2003)
    10. Human placental (Asymmetrical) diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase: purification to homogeneity and some properties. (PubMed id 8381042)1, 9 Lazewska D....Guranowski A. (Protein Expr. Purif. 1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 318 HGNC: 8049 AceView: NUDT2 Ensembl:ENSG00000164978 euGenes: HUgn318
    ECgene: NUDT2 Kegg: 318 H-InvDB: NUDT2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NUDT2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NUDT2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NUDT2 gene:
    Search GeneIP for patents involving NUDT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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