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Aliases for NUDT2 Gene

Aliases for NUDT2 Gene

  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 2 2 3
  • Diadenosine Tetraphosphatase 2 3 4
  • Ap4Aase 2 3 4
  • Diadenosine 5,5-P1,P4-Tetraphosphate Asymmetrical Hydrolase 3 4
  • Diadenosine 5,5-P1,P4-Tetraphosphate Pyrophosphohydrolase 2 3
  • Bis(5-Nucleosyl)-Tetraphosphatase (Asymmetrical) 2 3
  • Nucleoside Diphosphate-Linked Moiety X Motif 2 3 4
  • Ap4A Hydrolase 1 2 3
  • Nudix Motif 2 3 4
  • EC 3.6.1.17 4 63
  • APAH1 3 4
  • Ap4A Hydrolase 4

External Ids for NUDT2 Gene

Previous HGNC Symbols for NUDT2 Gene

  • APAH1

Previous GeneCards Identifiers for NUDT2 Gene

  • GC09P034641
  • GC09P034499
  • GC09P034319
  • GC09P034284

Summaries for NUDT2 Gene

Entrez Gene Summary for NUDT2 Gene

  • This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and four transcript variants, all encoding the same protein, have been identified. [provided by RefSeq, Sep 2011]

GeneCards Summary for NUDT2 Gene

NUDT2 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 2) is a Protein Coding gene. Among its related pathways are Cellular Senescence and Pyrimidine metabolism (KEGG). GO annotations related to this gene include GTP binding and bis(5-nucleosyl)-tetraphosphatase (asymmetrical) activity.

UniProtKB/Swiss-Prot for NUDT2 Gene

  • Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis

Gene Wiki entry for NUDT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT2 Gene

Genomics for NUDT2 Gene

Regulatory Elements for NUDT2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NUDT2 Gene

Chromosome:
9
Start:
34,329,506 bp from pter
End:
34,343,713 bp from pter
Size:
14,208 bases
Orientation:
Plus strand

Genomic View for NUDT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUDT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT2 Gene

Proteins for NUDT2 Gene

  • Protein details for NUDT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50583-AP4A_HUMAN
    Recommended name:
    Bis(5-nucleosyl)-tetraphosphatase [asymmetrical]
    Protein Accession:
    P50583
    Secondary Accessions:
    • D3DRM0
    • Q5T589

    Protein attributes for NUDT2 Gene

    Size:
    147 amino acids
    Molecular mass:
    16829 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Note=Divalent metal ions.;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NUDT2 Gene

neXtProt entry for NUDT2 Gene

Proteomics data for NUDT2 Gene at MOPED

Selected DME Specific Peptides for NUDT2 Gene

Post-translational modifications for NUDT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUDT2 Gene

Domains & Families for NUDT2 Gene

Gene Families for NUDT2 Gene

Suggested Antigen Peptide Sequences for NUDT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P50583

UniProtKB/Swiss-Prot:

AP4A_HUMAN :
  • Contains 1 nudix hydrolase domain.
  • Belongs to the Nudix hydrolase family.
Domain:
  • Contains 1 nudix hydrolase domain.
Family:
  • Belongs to the Nudix hydrolase family.
genes like me logo Genes that share domains with NUDT2: view

Function for NUDT2 Gene

Molecular function for NUDT2 Gene

GENATLAS Biochemistry:
nudix (nucleoside diphosphate linked moiety X)-type motif 2,hydrolase,putative mouse cleaning gene whose functions is to cleanse the cell of potentially deleterious endogenous metabolites and to modulate the accumulation of intermediates in biochemical pathways
UniProtKB/Swiss-Prot CatalyticActivity:
P(1),P(4)-bis(5-guanosyl) tetraphosphate + H(2)O = GTP + GMP
UniProtKB/Swiss-Prot Function:
Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis

Enzyme Numbers (IUBMB) for NUDT2 Gene

Gene Ontology (GO) - Molecular Function for NUDT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004081 bis(5-nucleosyl)-tetraphosphatase (asymmetrical) activity ISS 11738085
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IEA --
GO:0008803 bis(5-nucleosyl)-tetraphosphatase (symmetrical) activity TAS 7487923
GO:0016787 hydrolase activity --
genes like me logo Genes that share ontologies with NUDT2: view

Phenotypes for NUDT2 Gene

GenomeRNAi human phenotypes for NUDT2:
genes like me logo Genes that share phenotypes with NUDT2: view

Animal Model Products

miRNA for NUDT2 Gene

miRTarBase miRNAs that target NUDT2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NUDT2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for NUDT2 Gene

Localization for NUDT2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUDT2 Gene COMPARTMENTS Subcellular localization image for NUDT2 gene
Compartment Confidence
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for NUDT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with NUDT2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NUDT2 Gene

Pathways & Interactions for NUDT2 Gene

genes like me logo Genes that share pathways with NUDT2: view

Pathways by source for NUDT2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for NUDT2 Gene

Selected Interacting proteins: P50583-AP4A_HUMAN for NUDT2 Gene via I2D UniProtKB

Gene Ontology (GO) - Biological Process for NUDT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000302 response to reactive oxygen species TAS --
GO:0006139 nucleobase-containing compound metabolic process TAS 7487923
GO:0006915 apoptotic process ISS 11937063
genes like me logo Genes that share ontologies with NUDT2: view

No data available for SIGNOR curated interactions for NUDT2 Gene

Drugs & Compounds for NUDT2 Gene

(7) Drugs for NUDT2 Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Uridine 5'-monophosphate Experimental Pharma 0

(7) Additional Compounds for NUDT2 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diadenosine tetraphosphate
  • 5',5'''-Diadenosine tetraphosphate
  • Adenosine 5'-tetraphosphate, 5'-ester with adenosine
  • Adenosine-(5')-tetraphospho-(5')-adenosine
  • Diadenosine 5',5'''-P1,P4-tetraphosphate
  • P1,P4-Di(adenosin-5'-yl)tetraphosphate
5542-28-9
Diguanosine tetraphosphate
  • (ppG)2
  • Bis(5'-guanosyl) tetraphosphate
  • Bis(guanylyl) diphosphate
  • G(5')P4(5')G
  • GP4G
4130-19-2
P1,P4-Bis(5'-uridyl) tetraphosphate
  • UppppU
P1,P4-Bis(5'-xanthosyl) tetraphosphate
  • XppppX
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with NUDT2: view

Transcripts for NUDT2 Gene

Unigene Clusters for NUDT2 Gene

Nudix (nucleoside diphosphate linked moiety X)-type motif 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NUDT2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e
SP1: -
SP2: - -
SP3:
SP4: - - -
SP5: - - - -

Relevant External Links for NUDT2 Gene

GeneLoc Exon Structure for
NUDT2
ECgene alternative splicing isoforms for
NUDT2

Expression for NUDT2 Gene

mRNA expression in normal human tissues for NUDT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NUDT2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.4) and Oral epithelium (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for NUDT2 Gene



SOURCE GeneReport for Unigene cluster for NUDT2 Gene Hs.731743

genes like me logo Genes that share expression patterns with NUDT2: view

Protein tissue co-expression partners for NUDT2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NUDT2 Gene

Orthologs for NUDT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUDT2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NUDT2 35
  • 90.05 (n)
  • 90.97 (a)
NUDT2 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUDT2 35
  • 91.9 (n)
  • 92.36 (a)
NUDT2 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nudt2 35
  • 89.57 (n)
  • 89.12 (a)
Nudt2 16
Nudt2 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NUDT2 35
  • 99.32 (n)
  • 100 (a)
NUDT2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nudt2 35
  • 88.89 (n)
  • 87.76 (a)
oppossum
(Monodelphis domestica)
Mammalia NUDT2 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUDT2 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUDT2 35
  • 67.59 (n)
  • 62.5 (a)
NUDT2 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUDT2 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nudt2 35
  • 66.67 (n)
  • 63.38 (a)
Str.1563 35
zebrafish
(Danio rerio)
Actinopterygii nudt2 35
  • 62.35 (n)
  • 59.71 (a)
nudt2 36
  • 54 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008495 35
  • 55.73 (n)
  • 51.2 (a)
fruit fly
(Drosophila melanogaster)
Insecta Apf 35
  • 57.39 (n)
  • 48.87 (a)
Apf 36
  • 42 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ndx-4 35
  • 55.31 (n)
  • 50.72 (a)
ndx-4 36
  • 46 (a)
OneToOne
Species with no ortholog for NUDT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUDT2 Gene

ENSEMBL:
Gene Tree for NUDT2 (if available)
TreeFam:
Gene Tree for NUDT2 (if available)

Paralogs for NUDT2 Gene

No data available for Paralogs for NUDT2 Gene

Variants for NUDT2 Gene

Structural Variations from Database of Genomic Variants (DGV) for NUDT2 Gene

Variant ID Type Subtype PubMed ID
nsv893037 CNV Gain 21882294
nsv831542 CNV Gain 17160897
esv2738387 CNV Deletion 23290073
esv2738388 CNV Deletion 23290073

Variation tolerance for NUDT2 Gene

Residual Variation Intolerance Score: 59.68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.54; 11.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUDT2 Gene

HapMap Linkage Disequilibrium report
NUDT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for NUDT2 Gene

Disorders for NUDT2 Gene

Relevant External Links for NUDT2

Genetic Association Database (GAD)
NUDT2
Human Genome Epidemiology (HuGE) Navigator
NUDT2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUDT2
genes like me logo Genes that share disorders with NUDT2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUDT2 Gene

Publications for NUDT2 Gene

  1. Chromosomal localization of the human diadenosine 5',5"'-P1,P4-tetraphosphate pyrophosphohydrolase (Ap4A hydrolase) gene (APAH1) to 9p13. (PMID: 9479504) McLennan A.G. … RidanpAoAo M. (Genomics 1998) 2 23 67
  2. SARS coronavirus protein 7a interacts with human Ap4A-hydrolase. (PMID: 20144233) Vasilenko N. … Zakhartchouk A. (Virol. J. 2010) 23 67
  3. Novel diadenosine polyphosphate analogs with oxymethylene bridges replacing oxygen in the polyphosphate chain: potential substrates and/or inhibitors of Ap4A hydrolases. (PMID: 19210543) Guranowski A. … Blackburn G.M. (FEBS J. 2009) 23 67
  4. Structure and substrate-binding mechanism of human Ap4A hydrolase. (PMID: 15596429) Swarbrick J.D. … Gooley P.R. (J. Biol. Chem. 2005) 23 67
  5. 1H, 13C, and 15N resonance assignments of the 17 kDa Ap4A hydrolase from Homo sapiens in the presence and absence of ATP. (PMID: 15772762) Swarbrick J.D. … Gooley P.R. (J. Biomol. NMR 2005) 23 67

Products for NUDT2 Gene

Sources for NUDT2 Gene

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