NUDT2 Gene
protein-coding GIFtS: 56
GCID: GC09P034329
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nudix (nucleoside diphosphate linked moiety X)-type motif... (Previous symbol: APAH1)
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Aliases for NUDT2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 21 2 | | EC 3.6.1.173 8 | | APAH11 2 3 5 | | Ap4A Hydrolase 12 | | Diadenosine 5',5'''-P1,P4-Tetraphosphate Asymmetrical Hydrolase2 3 | | Bis(5'-Nucleosyl)-Tetraphosphatase (Asymmetrical)2 | | Diadenosine Tetraphosphatase2 3 | | Bis(5'-Nucleosyl)-Tetraphosphatase [Asymmetrical]2 | | Nucleoside Diphosphate-Linked Moiety X Motif 22 3 | | Diadenosine 5',5''-P1,P4-Tetraphosphate Pyrophosphohydrolase2 | | Nudix Motif 22 3 | | Ap4A Hydrolase3 | | Ap4Aase2 3 | | |
Export aliases for NUDT2 gene to outside databasesPrevious GC identifers: GC09P034641 GC09P034499 GC09P034319 GC09P034284 |
Summaries for NUDT2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for NUDT2: This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolasefamily. The gene product possesses a modification of the MutT sequence motif found in certain nucleotidepyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintainingthe intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be acandidate tumor suppressor gene. Alternative splicing has been observed at this locus and four transcript variants,all encoding the same protein, have been identified. (provided by RefSeq, Sep 2011) UniProtKB/Swiss-Prot: AP4A_HUMAN, P50583Function: Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis Gene Wiki entry for NUDT2
|
Genomic Views for NUDT2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008413.18
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the NUDT2 gene promoter: GR GR-beta HNF-1A Egr-4 FOXC1 HNF-1 HFH-1 GR-alpha NF-Y CBF(2) Other transcription factors
Search SABiosciences Chromatin IP Primers for NUDT2
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUDT2 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p13 Ensembl cytogenetic band: 9p13.3 HGNC cytogenetic band: 9p13NUDT2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P034329: view genomic region
(about GC identifiers)
Start:
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34,329,504 bp from pter |
End:
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34,343,709 bp from pter |
Size:
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14,206 bases |
Orientation:
|
plus strand |
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Proteins for NUDT2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: AP4A_HUMAN, P50583 (See
protein sequence)Recommended Name: Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] Size: 147 amino acids; 16829 Da
Cofactor: Divalent ions (By similarity)
4 PDB 3D structures from and Proteopedia for NUDT2:1XSA (3D)
  1XSB (3D)
  1XSC (3D)
  3U53 (3D)
 
Secondary accessions: D3DRM0 Q5T589Explore the universe of human proteins at neXtProt for NUDT2: NX_P50583
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P50583 4/5 DME Specific Peptides for NUDT2 (P50583) (see all 5)
NUDT2 Protein expression data from MOPED and PaxDb: About this image 
 REFSEQ proteins (4 alternative transcripts):
NP_001152.1 NP_001231319.1 NP_671701.1 NP_671702.1 ENSEMBL proteins: ENSP00000368455 ENSP00000344187 ENSP00000368452 ENSP00000368451 ENSP00000338397 Human Recombinant Protein Products for NUDT2:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IEA | -- |
NUDT2 for ontologies About GeneDecksing
NUDT2 Antibody Products: Assay Products for NUDT2: |
Protein
Domains / Families for NUDT2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NUDT2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P50583ProtoNet protein and cluster: P50583 2 Blocks protein families: IPB000086 NUDIX hydrolase IPB003565 Bis(5'-nucleosyl)-tetraphosphatase signature
UniProtKB/Swiss-Prot: AP4A_HUMAN, P50583Similarity: Belongs to the Nudix hydrolase familySimilarity: Contains 1 nudix hydrolase domain |
Function for NUDT2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Molecular Function: UniProtKB/Swiss-Prot Summary: AP4A_HUMAN, P50583Function: Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasisCatalytic activity: P(1),P(4)-bis(5'-guanosyl) tetraphosphate + H(2)O = GTP + GMP Genatlas biochemistry entry for NUDT2:nudix (nucleoside diphosphate linked moiety X)-type motif 2,hydrolase,putative mouse cleaning gene whose functions isto cleanse the cell of potentially deleterious endogenous metabolites and to modulate the accumulation ofintermediates in biochemical pathways Enzyme Number (IUBMB): EC 3.6.1.171 2
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004081 | bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity |
ISS | 11738085 | | GO:0005525 | GTP binding |
IEA | -- | | GO:0008803 | bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity |
TAS | 7487923 |
NUDT2 for ontologies About GeneDecksing
Animal Models:
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT2 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT2 (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT2 |
|
Pathways & Interactions for NUDT2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Purine metabolism | |
Pathway sources See GeneCards unified pathways Show all pathways
2
Kegg Pathways (Kegg details for NUDT2):
NUDT2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NUDT2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
 5/67 Interacting proteins for NUDT2 (P505833 ENSP000003383974) via UniProtKB, MINT, STRING, and/or I2D (see all 67)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
NUDT2 for ontologies About GeneDecksing
|
Drugs & Compounds for NUDT2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
NUDT2 for compounds About GeneDecksing
Browse Tocris compounds for NUDT2
10/13 HMDB Compounds for NUDT2 (see all 13) About this table 2 Novoseek chemical compound relationships for NUDT2 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| diadenosine tetraphosphate |
86.1 |
1 |
20144233 (1) |
| atp |
48.8 |
1 |
15772762 (1) |
Search CenterWatch for drugs/clinical trials and news about NUDT2 / AP4A 
|
Transcripts for NUDT2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for NUDT2 gene (4 alternative transcripts): NM_001161.4 NM_001244390.1 NM_147172.2 NM_147173.2 Unigene Cluster for NUDT2: Nudix (nucleoside diphosphate linked moiety X)-type motif 2 Hs.731743 [show with all ESTs]Unigene Representative Sequence: NM_0011615 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000379158(uc003zub.3) ENST00000346365(uc003zud.3 uc022bga.1) ENST00000379155(uc003zuc.3) ENST00000379154 ENST00000337747
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT2 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT2 (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): NUDT2 (NM_001161) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NUDT2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUDT2  |
Additional cDNA sequence: BC004926.2 U30313.1 7 DOTS entries: DT.415696 DT.97844814 DT.97844813 DT.95272416 DT.92061494 DT.75156207 DT.95272419 24/154 AceView cDNA sequences (see all 154): BF059736 BC004926 BU619430 CB305496 AA256617 BM681712 BU739666 AA806464 AA632250 AI265810 F21141 BQ648868 BQ647440 BM852225 AW292837 BM818895 BQ939416 AI381724 BQ961312 NM_147173 AA062607 CA413128 BM784602 BM831018 GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for NUDT2 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | |
| SP1: | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for NUDT2
|
Expression for NUDT2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NUDT2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: ACAGCCAAGA
 About this image See NUDT2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for NUDT2
SOURCE GeneReport for Unigene cluster: Hs.731743 SABiosciences Expression via Pathway-Focused PCR Array including NUDT2:
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUDT2 Browse OriGene validated miRNA SYBR primer pairs
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| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT2 |
Orthologs for NUDT2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for NUDT2 gene from 7/18 species (see all 18) About this table
ENSEMBL Gene Tree for NUDT2 (if available) TreeFam Gene Tree for NUDT2 (if available)  |
Paralogs for NUDT2 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| -- |
Genomic Variants for NUDT2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 9 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for NUDT2 (34329504 - 34343709 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for NUDT2: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NUDT2 |
|
Disorders
/ Diseases for NUDT2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NUDT2 for disorders About GeneDecksing
OMIM gene information: 602852
OMIM disorders: --
4 diseases for NUDT2: About MalaCardscartilage-hair hypoplasia breast carcinoma carcinoma malaria 1 disease from the University of Copenhagen DISEASES database for NUDT2:cartilage-hair hypoplasia Human Genome Epidemiology (HuGE) Navigator: NUDT2 (1 document) Export disorders for NUDT2 gene to outside databases
|
Publications for NUDT2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NUDT2 gene, integrated from 9 sources (see all 31): (articles sorted by number of sources associating them with NUDT2) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Human diadenosine 5',5''-P1,P4-tetraphosphate pyrophosphohydrolase is a member of the MutT family of nucleotide pyrophosphatases. (PubMed id 7487923)1, 2, 3 Thorne N.M.H....McLennan A.G. (1995)
- Chromosomal localization of the human diadenosine 5', 5''-P1,P4-tetraphosphate pyrophosphohydrolase (Ap4A hydrolase) gene (APAH1 ) to 9p13. (PubMed id 9479504)1, 3, 9 McLennan A.G....RidanpAoAo M. (1998)
- Structure and substrate-binding mechanism of human Ap4A hydrolase. (PubMed id 15596429)1, 2, 9 Swarbrick J.D....Gooley P.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- SARS coronavirus protein 7a interacts with human Ap4A -hydrolase. (PubMed id 20144233)1, 9 Vasilenko N....Zakhartchouk A. (2010)
- Diadenosine 5',5''-P1,P4-tetraphosphate hydrolase is present in human erythrocytes, leukocytes and platelets. (PubMed id 7767787)1, 9 Hankin S....McLennan A.G. (1995)
- 1H, 13C, and 15N resonance assignments of the 17 kDa Ap4A hydrolase from Homo sapiens in the presence and absence of ATP. (PubMed id 15772762)1, 9 Swarbrick J.D....Gooley P.R. (2005)
- Metabolic transformation of AZTp4A by Ap4A hydrolase regenerates AZT triphosphate. (PubMed id 12767470)1, 9 Pitcher W.H....London R.E. (2003)
- Human placental (Asymmetrical) diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase: purification to homogeneity and some properties. (PubMed id 8381042)1, 9 Lazewska D....Guranowski A. (1993)
- Nudix-type motif 2 in human breast carcinoma: a poten t prognostic factor associated with cell proliferation. (PubMed id 20533549)1 Oka K....Sasano H. (2011)
|
External Searches for NUDT2 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing NUDT2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NUDT2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NUDT2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
|
About This Section
| Patent Information for NUDT2 gene: Search GeneIP for patents involving NUDT2
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for NUDT2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory) About This Section
|
 | |
 | |
 |
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| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT2 |
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