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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NUDT2 Gene

protein-coding   GIFtS: 60
GCID: GC09P034329

Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif...


(Previous symbol: APAH1)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 21 2     Nudix Motif 22 3
APAH11 2 3 5     EC 3.6.1.173 8
Ap4Aase1 2 3     5''-P11
Diadenosine Tetraphosphatase1 2 3     Diadenosine 5'1
Ap4A Hydrolase 11 2     P4-Tetraphosphate Pyrophosphohydrolase1
Bis(5'-Nucleosyl)-Tetraphosphatase (Asymmetrical)1 2     Bis(5'-Nucleosyl)-Tetraphosphatase [Asymmetrical]2
Diadenosine 5',5'''-P1,P4-Tetraphosphate Asymmetrical Hydrolase2 3     Diadenosine 5',5''-P1,P4-Tetraphosphate Pyrophosphohydrolase2
Nucleoside Diphosphate-Linked Moiety X Motif 22 3     Ap4A Hydrolase3

External Ids:    HGNC: 80491   Entrez Gene: 3182   Ensembl: ENSG000001649787   OMIM: 6028525   UniProtKB: P505833   

Export aliases for NUDT2 gene to outside databases

Previous GC identifers: GC09P034641 GC09P034499 GC09P034319 GC09P034284


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NUDT2 Gene:
This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX
hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain
nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible
for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be
established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this
locus and four transcript variants, all encoding the same protein, have been identified. (provided by RefSeq, Sep
2011)

GeneCards Summary for NUDT2 Gene: 
NUDT2 (nudix (nucleoside diphosphate linked moiety X)-type motif 2) is a protein-coding gene. Diseases associated with NUDT2 include cartilage-hair hypoplasia, and among its related super-pathways are Pyrimidine metabolism. GO annotations related to this gene include bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity and GTP binding.

UniProtKB/Swiss-Prot: AP4A_HUMAN, P50583
Function: Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis

Gene Wiki entry for NUDT2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NUDT2 gene promoter:
         GR   GR-beta   HNF-1A   Egr-4   FOXC1   HNF-1   HFH-1   GR-alpha   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): NUDT2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NUDT2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUDT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p13

NUDT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUDT2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P034329:  view genomic region     (about GC identifiers)

Start:
34,329,504 bp from pter      End:
34,343,709 bp from pter
Size:
14,206 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AP4A_HUMAN, P50583 (See protein sequence)
Recommended Name: Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]  
Size: 147 amino acids; 16829 Da
Cofactor: Divalent ions (By similarity)
5 PDB 3D structures from and Proteopedia for NUDT2:
1XSA (3D)        1XSB (3D)        1XSC (3D)        3U53 (3D)        4IJX (3D)    
Secondary accessions: D3DRM0 Q5T589

Explore the universe of human proteins at neXtProt for NUDT2: NX_P50583

Explore proteomics data for NUDT2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P50583

  • 4/5 DME Specific Peptides for NUDT2 (P50583) (see all 5)
     EHQAYRWL  IEFLLLQAS  TALRETQEE  LQEGHQFLCS 

    NUDT2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NUDT2 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001152.1  NP_001231319.1  NP_671701.1  NP_671702.1  

    ENSEMBL proteins: 
     ENSP00000368455   ENSP00000344187   ENSP00000368452  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--

    NUDT2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    NUDT: Nudix motif containing

    4 InterPro protein domains:
     IPR015797 NUDIX_hydrolase_dom-like
     IPR020084 NUDIX_hydrolase_CS
     IPR000086 NUDIX_hydrolase_dom
     IPR003565 Tetra_PHTase

    Graphical View of Domain Structure for InterPro Entry P50583

    ProtoNet protein and cluster: P50583

    2 Blocks protein domains:
    IPB000086 NUDIX hydrolase
    IPB003565 Bis(5'-nucleosyl)-tetraphosphatase signature


    UniProtKB/Swiss-Prot: AP4A_HUMAN, P50583
    Similarity: Belongs to the Nudix hydrolase family
    Similarity: Contains 1 nudix hydrolase domain


    NUDT2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AP4A_HUMAN, P50583
    Function: Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis
    Catalytic activity: P(1),P(4)-bis(5'-guanosyl) tetraphosphate + H(2)O = GTP + GMP

         Genatlas biochemistry entry for NUDT2:
    nudix (nucleoside diphosphate linked moiety X)-type motif 2,hydrolase,putative mouse cleaning gene whose functions
    is to cleanse the cell of potentially deleterious endogenous metabolites and to modulate the accumulation of
    intermediates in biochemical pathways

         Enzyme Number (IUBMB): EC 3.6.1.171 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004081bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity ISS11738085
    GO:0005525GTP binding IEA--
    GO:0008803bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity TAS7487923
    GO:0016787hydrolase activity ----
         
    NUDT2 for ontologies           About GeneDecksing


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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NUDT2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Purine metabolism
    Purine metabolism0.38
    Pyrimidine metabolism0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    2         Kegg Pathways  (Kegg details for NUDT2):
        Purine metabolism
    Pyrimidine metabolism


    NUDT2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NUDT2

    1 Interacting protein for NUDT2 (P505833) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GAPDHP044063I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006139nucleobase-containing compound metabolic process TAS7487923
    GO:0006915apoptotic process ISS10452553

    NUDT2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NUDT2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NUDT2 (AP4A)

    10/13 HMDB Compounds for NUDT2 (see all 13)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Diadenosine tetraphosphateDiadenosine 5',5'''-P1,P4-tetraphosphate (see all 6)5542-28-9--
    Diguanosine tetraphosphate(ppG)2 (see all 9)4130-19-2--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    P1,P4-Bis(5'-uridyl) tetraphosphateUppppU ----
    P1,P4-Bis(5'-xanthosyl) tetraphosphateXppppX (see all 2)----
    Uridine 5'-monophosphate5'-UMP (see all 12)58-97-9--
    Uridine triphosphate5'-UTP (see all 7)63-39-8--

    2 Novoseek inferred chemical compound relationships for NUDT2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    diadenosine tetraphosphate 86.1 1 20144233 (1)
    atp 48.8 1 15772762 (1)

    Search CenterWatch for drugs/clinical trials and news about NUDT2 / AP4A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NUDT2 gene (4 alternative transcripts): 
    NM_001161.4  NM_001244390.1  NM_147172.2  NM_147173.2  

    Unigene Cluster for NUDT2:

    Nudix (nucleoside diphosphate linked moiety X)-type motif 2
    Hs.731743  [show with all ESTs]
    Unigene Representative Sequence: NM_001161
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379158(uc003zub.3) ENST00000346365(uc003zud.3 uc022bga.1)
    ENST00000379155(uc003zuc.3)
    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate NUDT2:
    hsa-miR-142-5p hsa-miR-340
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    Additional mRNA sequence: 

    BC004926.2 U30313.1 

    7 DOTS entries:

    DT.415696  DT.97844814  DT.97844813  DT.95272416  DT.92061494  DT.75156207  DT.95272419 

    24/154 AceView cDNA sequences (see all 154):

    BU786517 BU619430 AI339040 CA413128 BQ648868 BQ961312 NM_147172 BF059736 
    BU533284 BM719797 BM852225 AW292786 AA806464 BM681712 AA310093 BU689686 
    AA632250 BF433119 AI381724 CB528695 T24918 BC004926 BM818895 BQ007098 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for NUDT2    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e
    SP1:                          -                                                   
    SP2:                          -     -                                             
    SP3:                                                                              
    SP4:                          -     -     -                                       
    SP5:                          -     -     -     -                                 


    ECgene alternative splicing isoforms for NUDT2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NUDT2 expression in normal human tissues (normalized intensities)      NUDT2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAGCCAAGA
    NUDT2 Expression
    About this image


    NUDT2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 14 entries
             Thalamus
             Olfactory Bulb   
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             heart/atrium   
     
     Blood (Cardiovascular System)
             mouse/organ system/cardiovascular system   
     
     Larynx (Respiratory System)

    See NUDT2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NUDT2

    SOURCE GeneReport for Unigene cluster: Hs.731743
        SABiosciences Expression via Pathway-Focused PCR Array including NUDT2: 
              Apoptosis 384HT in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NUDT2 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nudt21 , 5 nudix (nucleoside diphosphate linked moiety X)-type more1, 5 89.57(n)1
    89.12(a)1
      4 (21.65 cM)5
    664011  NM_025539.21  NP_079815.21 
     414651515 
    chicken
    (Gallus gallus)
    Aves NUDT21 nudix (nucleoside diphosphate linked moiety X)-type more 68.06(n)
    63.19(a)
      427399  XM_424973.3  XP_424973.1 
    lizard
    (Anolis carolinensis)
    Reptilia NUDT26
    Uncharacterized protein
    64(a)
    1 ↔ 1
    GL343372.1(1029189-1030911)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.15632 Transcribed sequence with weak similarity to protein more 78.15(n)    137726250 
    zebrafish
    (Danio rerio)
    Actinopterygii nudt21 nudix (nucleoside diphosphate linked moiety X)-type more 62.35(n)
    59.71(a)
      436595  NM_001002323.1  NP_001002323.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Apf1 diadenosine tetraphosphate hydrolase 57.39(n)
    48.87(a)
      318908  NM_164880.2  NP_723505.2 
    worm
    (Caenorhabditis elegans)
    Secernentea ndx-41 Protein NDX-4 56.05(n)
    51.85(a)
      189639  NM_061012.3  NP_493413.1 


    ENSEMBL Gene Tree for NUDT2 (if available)
    TreeFam Gene Tree for NUDT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/258 SNPs in NUDT2 are shown (see all 258)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1808696601,2
    --34331330(+) TCAGAC/TCCTCT 4 -- int10--------
    rs1512248221,2
    C--34331376(+) AAAGTA/GGGTGT 4 -- int10--------
    rs172598171,2
    C,F--34331466(+) CTGACT/GGCATA 4 -- int17Minor allele frequency- G:0.05NA 268
    rs1391302941,2
    --34331519(+) AATGCC/TTGGAA 4 -- int10--------
    rs1865603001,2
    --34331582(+) GGAATA/GTGAGC 4 -- int10--------
    rs1919911961,2
    --34331590(+) AGCTGC/TAGAGG 4 -- int10--------
    rs727331251,2
    C--34331672(+) AAAAAA/GATTGT 4 -- int13Minor allele frequency- G:0.13NA EA 242
    rs1838624491,2
    --34331688(+) TAAAAA/GTAATT 4 -- int10--------
    rs1884577251,2
    --34331839(+) CACCCC/GCTCCT 4 -- int10--------
    rs557081431,2
    C--34331880(+) CTTTCC/TCTTGG 4 -- int14Minor allele frequency- T:0.09NA WA EA 360

    HapMap Linkage Disequilibrium report for NUDT2 (34329504 - 34343709 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for NUDT2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2738388CNV Deletion23290073
    esv2738387CNV Deletion23290073
    nsv831542CNV Gain17160897
    nsv893037CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602852    OMIM disorders: --

    2 diseases for NUDT2:    About MalaCards
    cartilage-hair hypoplasia    

    1 disease from the University of Copenhagen DISEASES database for NUDT2:
    cartilage-hair hypoplasia

    NUDT2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NUDT2
    Human Genome Epidemiology (HuGE) Navigator: NUDT2 (1 document)

    Export disorders for NUDT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NUDT2 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with NUDT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human diadenosine 5',5''-P1,P4-tetraphosphate pyrophosphohydrolase is a member of the MutT family of nucleotide pyrophosphatases. (PubMed id 7487923)1, 2, 3 Thorne N.M.H....McLennan A.G. (1995)
    2. Chromosomal localization of the human diadenosine 5', 5''-P1,P4-tetraphosphate pyrophosphohydrolase (Ap4A hydrolase) gene (APAH1 ) to 9p13. (PubMed id 9479504)1, 3, 9 McLennan A.G....RidanpAoAo M. (1998)
    3. Structure and substrate-binding mechanism of human Ap4A hydrolase. (PubMed id 15596429)1, 2, 9 Swarbrick J.D....Gooley P.R. (2005)
    4. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. SARS coronavirus protein 7a interacts with human Ap4A -hydrolase. (PubMed id 20144233)1, 9 Vasilenko N....Zakhartchouk A. (2010)
    7. Diadenosine 5',5''-P1,P4-tetraphosphate hydrolase is present in human erythrocytes, leukocytes and platelets. (PubMed id 7767787)1, 9 Hankin S....McLennan A.G. (1995)
    8. 1H, 13C, and 15N resonance assignments of the 17 kDa Ap4A hydrolase from Homo sapiens in the presence and absence of ATP. (PubMed id 15772762)1, 9 Swarbrick J.D....Gooley P.R. (2005)
    9. Metabolic transformation of AZTp4A by Ap4A hydrolase regenerates AZT triphosphate. (PubMed id 12767470)1, 9 Pitcher W.H....London R.E. (2003)
    10. Human placental (Asymmetrical) diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase: purification to homogeneity and some properties. (PubMed id 8381042)1, 9 Lazewska D....Guranowski A. (1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 318 HGNC: 8049 AceView: NUDT2 Ensembl:ENSG00000164978 euGenes: HUgn318
    ECgene: NUDT2 Kegg: 318 H-InvDB: NUDT2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NUDT2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NUDT2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NUDT2 gene:
    Search GeneIP for patents involving NUDT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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