Aliases for NUDT2 Gene
- Nudix Hydrolase 2 2 3 5
- Diadenosine Tetraphosphatase 2 3 4
- Ap4Aase 2 3 4
- Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 2 2 3
- Diadenosine 5,5-P1,P4-Tetraphosphate Asymmetrical Hydrolase 3 4
- Diadenosine 5,5-P1,P4-Tetraphosphate Pyrophosphohydrolase 2 3
- Bis(5-Nucleosyl)-Tetraphosphatase (Asymmetrical) 2 3
External Ids for NUDT2 Gene
Previous HGNC Symbols for NUDT2 Gene
Previous GeneCards Identifiers for NUDT2 Gene
This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and four transcript variants, all encoding the same protein, have been identified. [provided by RefSeq, Sep 2011]
GeneCards Summary for NUDT2 Gene
NUDT2 (Nudix Hydrolase 2) is a Protein Coding gene. Among its related pathways are Pyrimidine metabolism (KEGG) and Cellular Senescence. GO annotations related to this gene include GTP binding and bis(5-nucleosyl)-tetraphosphatase (asymmetrical) activity.
UniProtKB/Swiss-Prot for NUDT2 Gene
Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis.