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Aliases for NUDT19 Gene

Aliases for NUDT19 Gene

  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 19 2 3
  • Nudix Motif 19 3 4
  • Nucleoside Diphosphate-Linked Moiety X Motif 19, Mitochondrial 3
  • EC 3.6.1.- 4
  • EC 3.6.1 63
  • RP2 3

External Ids for NUDT19 Gene

Previous GeneCards Identifiers for NUDT19 Gene

  • GC19P037876
  • GC19P033182
  • GC19P029686

Summaries for NUDT19 Gene

GeneCards Summary for NUDT19 Gene

NUDT19 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 19) is a Protein Coding gene. Among its related pathways are Peroxisome. GO annotations related to this gene include receptor binding and hydrolase activity.

UniProtKB/Swiss-Prot for NUDT19 Gene

  • Coenzyme A diphosphatase that mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoA and branched-chain fatty-acyl-CoA esters. At low substrate concentrations medium and long-chain fatty-acyl-CoA esters are the primary substrates (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT19 Gene

Genomics for NUDT19 Gene

Regulatory Elements for NUDT19 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NUDT19 Gene

Start:
32,666,281 bp from pter
End:
32,713,796 bp from pter
Size:
47,516 bases
Orientation:
Plus strand

Genomic View for NUDT19 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUDT19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT19 Gene

Proteins for NUDT19 Gene

  • Protein details for NUDT19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MXV4-NUD19_HUMAN
    Recommended name:
    Nucleoside diphosphate-linked moiety X motif 19, mitochondrial
    Protein Accession:
    A8MXV4
    Secondary Accessions:

    Protein attributes for NUDT19 Gene

    Size:
    375 amino acids
    Molecular mass:
    42233 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

neXtProt entry for NUDT19 Gene

Proteomics data for NUDT19 Gene at MOPED

Selected DME Specific Peptides for NUDT19 Gene

Post-translational modifications for NUDT19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUDT19 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for NUDT19 Gene

Gene Families for NUDT19 Gene

HGNC:
  • NUDT :Nudix motif containing

Protein Domains for NUDT19 Gene

Suggested Antigen Peptide Sequences for NUDT19 Gene

Graphical View of Domain Structure for InterPro Entry

A8MXV4

UniProtKB/Swiss-Prot:

NUD19_HUMAN :
  • A8MXV4
Domain:
  • Contains 1 nudix hydrolase domain.
Family:
  • Belongs to the Nudix hydrolase family.
genes like me logo Genes that share domains with NUDT19: view

Function for NUDT19 Gene

Molecular function for NUDT19 Gene

UniProtKB/Swiss-Prot Function: Coenzyme A diphosphatase that mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoA and branched-chain fatty-acyl-CoA esters. At low substrate concentrations medium and long-chain fatty-acyl-CoA esters are the primary substrates (By similarity).

Enzyme Numbers (IUBMB) for NUDT19 Gene

Gene Ontology (GO) - Molecular Function for NUDT19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 20178365
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NUDT19: view

Animal Model Products

CRISPR Products

miRNA for NUDT19 Gene

miRTarBase miRNAs that target NUDT19

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NUDT19 Gene

Localization for NUDT19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDT19 Gene

Peroxisome. Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUDT19 Gene COMPARTMENTS Subcellular localization image for NUDT19 gene
Compartment Confidence
mitochondrion 3
cytosol 2
peroxisome 2
nucleus 1

Gene Ontology (GO) - Cellular Components for NUDT19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005739 mitochondrion IEA --
GO:0005777 peroxisome IEA --
genes like me logo Genes that share ontologies with NUDT19: view

Pathways for NUDT19 Gene

SuperPathways for NUDT19 Gene

Superpath Contained pathways
1 Peroxisome
genes like me logo Genes that share pathways with NUDT19: view

Pathways by source for NUDT19 Gene

1 KEGG pathway for NUDT19 Gene

Interacting Proteins for NUDT19 Gene

Gene Ontology (GO) - Biological Process for NUDT19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with NUDT19: view

Compounds for NUDT19 Gene

(6) HMDB Compounds for NUDT19 Gene

Compound Synonyms Cas Number PubMed IDs
Eicosanoyl-CoA
  • Arachidinoyl-CoA
15895-27-9
Heptadecanoyl CoA
  • Heptadecanoyl coenzyme A
3546-17-6
Magnesium
  • Magnesium
7439-95-4
Manganese
  • manganese
7439-96-5
Palmityl-CoA
  • Palmityl-CoA
1763-10-6
genes like me logo Genes that share compounds with NUDT19: view

Transcripts for NUDT19 Gene

mRNA/cDNA for NUDT19 Gene

(23) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NUDT19 Gene

Nudix (nucleoside diphosphate linked moiety X)-type motif 19:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NUDT19

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT19 Gene

No ASD Table

Relevant External Links for NUDT19 Gene

GeneLoc Exon Structure for
NUDT19
ECgene alternative splicing isoforms for
NUDT19

Expression for NUDT19 Gene

mRNA expression in normal human tissues for NUDT19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUDT19 Gene

SOURCE GeneReport for Unigene cluster for NUDT19 Gene Hs.203961

genes like me logo Genes that share expressions with NUDT19: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NUDT19 Gene

Orthologs for NUDT19 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUDT19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUDT19 35
  • 99.01 (n)
  • 99.11 (a)
NUDT19 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC617221 35
  • 79.5 (n)
  • 72.19 (a)
NUDT19 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUDT19 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nudt19 35
  • 74.64 (n)
  • 66.95 (a)
Nudt19 16
Nudt19 36
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NUDT19 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUDT19 36
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nudt19 35
  • 72.67 (n)
  • 66.57 (a)
chicken
(Gallus gallus)
Aves NUDT19 35
  • 63.83 (n)
  • 55.43 (a)
NUDT19 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUDT19 36
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nudt19 35
  • 48.46 (n)
  • 40.34 (a)
zebrafish
(Danio rerio)
Actinopterygii nudt19 35
  • 52.52 (n)
  • 42.74 (a)
nudt19 36
  • 37 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009927 35
  • 44.34 (n)
  • 33.65 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10194 35
  • 47.28 (n)
  • 35.01 (a)
CG10194 36
  • 33 (a)
OneToMany
CG10195 36
  • 29 (a)
OneToMany
CG18094 36
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ndx-7 35
  • 43.14 (n)
  • 34.51 (a)
ndx-7 36
  • 29 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToOne
Species with no ortholog for NUDT19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUDT19 Gene

ENSEMBL:
Gene Tree for NUDT19 (if available)
TreeFam:
Gene Tree for NUDT19 (if available)

Paralogs for NUDT19 Gene

genes like me logo Genes that share paralogs with NUDT19: view

No data available for Paralogs for NUDT19 Gene

Variants for NUDT19 Gene

Sequence variations from dbSNP and Humsavar for NUDT19 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs259295 -- 32,678,833(-) TACAC(C/T)TGTGT intron-variant
rs259296 -- 32,679,073(-) CAGTC(C/T)GGGCA intron-variant
rs704155 -- 32,689,426(-) caagg(C/T)gggcg intron-variant
rs881273 -- 32,691,414(-) ATGGA(C/T)GAGCC upstream-variant-2KB, intron-variant
rs891166 -- 32,691,519(-) AAGGA(C/T)CCACA upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUDT19 Gene

Variant ID Type Subtype PubMed ID
dgv3838n71 CNV Loss 21882294
nsv911575 CNV Loss 21882294

Relevant External Links for NUDT19 Gene

HapMap Linkage Disequilibrium report
NUDT19
Human Gene Mutation Database (HGMD)
NUDT19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT19 Gene

Disorders for NUDT19 Gene

Relevant External Links for NUDT19

Genetic Association Database (GAD)
NUDT19
Human Genome Epidemiology (HuGE) Navigator
NUDT19
genes like me logo Genes that share disorders with NUDT19: view

No data available for UniProtKB/Swiss-Prot for NUDT19 Gene

Publications for NUDT19 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  2. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  3. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  4. Global identification of modular cullin-RING ligase substrates. (PMID: 21963094) Emanuele M.J. … Elledge S.J. (Cell 2011) 3
  5. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PMID: 22797925) Aichem A. … Groettrup M. (J. Cell. Sci. 2012) 3

Products for NUDT19 Gene

Sources for NUDT19 Gene

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