Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NUDT19 Gene

Aliases for NUDT19 Gene

  • Nudix Hydrolase 19 2 3 5
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 19 2 3
  • Nudix Motif 19 3 4
  • Nucleoside Diphosphate-Linked Moiety X Motif 19, Mitochondrial 3
  • Nucleoside Diphosphate-Linked Moiety X Motif 19 3
  • CTC-379B2.4 3
  • EC 3.6.1.- 4
  • EC 3.6.1 61
  • RP2 3

External Ids for NUDT19 Gene

Previous GeneCards Identifiers for NUDT19 Gene

  • GC19P037876
  • GC19P033182
  • GC19P029686

Summaries for NUDT19 Gene

GeneCards Summary for NUDT19 Gene

NUDT19 (Nudix Hydrolase 19) is a Protein Coding gene. Among its related pathways are Metabolism and Peroxisome. GO annotations related to this gene include receptor binding and hydrolase activity.

UniProtKB/Swiss-Prot for NUDT19 Gene

  • Coenzyme A diphosphatase that mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoA and branched-chain fatty-acyl-CoA esters. At low substrate concentrations medium and long-chain fatty-acyl-CoA esters are the primary substrates (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT19 Gene

Genomics for NUDT19 Gene

Regulatory Elements for NUDT19 Gene

Enhancers for NUDT19 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F032691 1.1 ENCODE 30.3 +25.9 25924 3.0 HDGF PKNOX1 WRNIP1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF143 FOS GPATCH1 NUDT19 LOC105372367 FAAP24 LOC100996681 ENSG00000267012 RPL21P131 AKR1B1P7 LINC01533 SLC7A9
GH19F032793 1 Ensembl ENCODE 25.7 +128.2 128187 2.3 PKNOX1 TFAP4 NR2F1 CEBPB ZNF384 PPARG RARA ZNF121 TCF7 KDM1A NUDT19 SLC7A9 LOC105372367 CEP89 PIR46993 GC19M032770
GH19F032695 0.8 ENCODE 29.8 +30.2 30158 2.0 KLF1 ZNF211 INSM2 ZNF140 CEBPG ZIC2 ZNF644 ZNF155 YY1 ZFHX2 GPATCH1 NUDT19 LOC105372367 GC19M032695 PIR51776
GH19F032830 0.7 Ensembl ENCODE 27.4 +164.5 164517 1.0 PKNOX1 PBX2 SPI1 NUDT19 SLC7A9 LOC105372367 ENSG00000267555 PIR63022
GH19F032868 1.1 Ensembl ENCODE 15.4 +203.6 203641 2.6 CTCF TBP TFAP4 ZNF146 SAP130 ARID4B ZNF384 ZIC2 RAD21 RARA SLC7A9 NUDT19 FAAP24 ANKRD27 RGS9BP CHST8 GC19M032863 RN7SKP22
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NUDT19 on UCSC Golden Path with GeneCards custom track

Genomic Location for NUDT19 Gene

Chromosome:
19
Start:
32,666,296 bp from pter
End:
32,713,796 bp from pter
Size:
47,501 bases
Orientation:
Plus strand

Genomic View for NUDT19 Gene

Genes around NUDT19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDT19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDT19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT19 Gene

Proteins for NUDT19 Gene

  • Protein details for NUDT19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MXV4-NUD19_HUMAN
    Recommended name:
    Nucleoside diphosphate-linked moiety X motif 19
    Protein Accession:
    A8MXV4

    Protein attributes for NUDT19 Gene

    Size:
    375 amino acids
    Molecular mass:
    42233 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

neXtProt entry for NUDT19 Gene

Selected DME Specific Peptides for NUDT19 Gene

A8MXV4:
  • GFRLLLLQR
  • LCAHLDCTPDIWALH
  • FLSKEIWL
  • GGVLDAAD
  • LLPGDELY
  • FEEAGVLLLRPR

Post-translational modifications for NUDT19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUDT19 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for NUDT19 Gene

Gene Families for NUDT19 Gene

Protein Domains for NUDT19 Gene

Suggested Antigen Peptide Sequences for NUDT19 Gene

Graphical View of Domain Structure for InterPro Entry

A8MXV4

UniProtKB/Swiss-Prot:

NUD19_HUMAN :
  • Contains 1 nudix hydrolase domain.
  • Belongs to the Nudix hydrolase family.
Domain:
  • Contains 1 nudix hydrolase domain.
Family:
  • Belongs to the Nudix hydrolase family.
genes like me logo Genes that share domains with NUDT19: view

Function for NUDT19 Gene

Molecular function for NUDT19 Gene

UniProtKB/Swiss-Prot Function:
Coenzyme A diphosphatase that mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoA and branched-chain fatty-acyl-CoA esters. At low substrate concentrations medium and long-chain fatty-acyl-CoA esters are the primary substrates (By similarity).

Enzyme Numbers (IUBMB) for NUDT19 Gene

Gene Ontology (GO) - Molecular Function for NUDT19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 20178365
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0047617 acyl-CoA hydrolase activity TAS --
genes like me logo Genes that share ontologies with NUDT19: view

Phenotypes for NUDT19 Gene

MGI mutant phenotypes for NUDT19:
inferred from 1 alleles
GenomeRNAi human phenotypes for NUDT19:
genes like me logo Genes that share phenotypes with NUDT19: view

Animal Models for NUDT19 Gene

MGI Knock Outs for NUDT19:

Animal Model Products

  • Taconic Biosciences Mouse Models for NUDT19

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NUDT19 Gene

Localization for NUDT19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDT19 Gene

Peroxisome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUDT19 gene
Compartment Confidence
peroxisome 5
mitochondrion 4
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for NUDT19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005739 mitochondrion IEA --
GO:0005777 peroxisome IEA --
GO:0005782 peroxisomal matrix TAS --
genes like me logo Genes that share ontologies with NUDT19: view

Pathways & Interactions for NUDT19 Gene

genes like me logo Genes that share pathways with NUDT19: view

Pathways by source for NUDT19 Gene

Gene Ontology (GO) - Biological Process for NUDT19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase TAS --
genes like me logo Genes that share ontologies with NUDT19: view

No data available for SIGNOR curated interactions for NUDT19 Gene

Drugs & Compounds for NUDT19 Gene

(2) Drugs for NUDT19 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Approved Nutra 34
Magnesium Nutra 0

(4) Additional Compounds for NUDT19 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Eicosanoyl-CoA
  • Arachidinoyl-CoA
  • Arachidinoyl-Coenzyme A
  • Arachidoyl coenzyme A
  • Arachidoyl-CoA
  • Arachidoyl-Coenzyme A
15895-27-9
Heptadecanoyl CoA
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid coa
  • Heptadecanoyl coenzyme A
  • Heptadecanoyl-coA
3546-17-6
Palmityl-CoA
  • Hexadecanoyl CoA
  • Hexadecanoyl Coenzyme A
  • Palmitoyl CoA
  • Palmitoyl coenzyme a
  • Palmitoyl-CoA
1763-10-6
stearoyl-coa
  • Octadecanoyl-CoA
  • Octadecanoyl-coenzyme A
  • S-Octadecanoate
  • S-Octadecanoate CoA
  • S-Octadecanoate Coenzyme A
362-66-3
genes like me logo Genes that share compounds with NUDT19: view

Transcripts for NUDT19 Gene

mRNA/cDNA for NUDT19 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(23) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NUDT19 Gene

Nudix (nucleoside diphosphate linked moiety X)-type motif 19:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT19 Gene

No ASD Table

Relevant External Links for NUDT19 Gene

GeneLoc Exon Structure for
NUDT19
ECgene alternative splicing isoforms for
NUDT19

Expression for NUDT19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NUDT19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NUDT19 Gene

This gene is overexpressed in Stomach (12.1) and Adrenal (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NUDT19 Gene



Protein tissue co-expression partners for NUDT19 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NUDT19 Gene:

NUDT19

SOURCE GeneReport for Unigene cluster for NUDT19 Gene:

Hs.203961
genes like me logo Genes that share expression patterns with NUDT19: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NUDT19 Gene

Orthologs for NUDT19 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUDT19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUDT19 34 35
  • 99.01 (n)
cow
(Bos Taurus)
Mammalia LOC617221 34
  • 79.5 (n)
NUDT19 35
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nudt19 34 16 35
  • 74.64 (n)
rat
(Rattus norvegicus)
Mammalia Nudt19 34
  • 72.67 (n)
dog
(Canis familiaris)
Mammalia NUDT19 35
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NUDT19 35
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUDT19 35
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUDT19 34 35
  • 63.83 (n)
lizard
(Anolis carolinensis)
Reptilia NUDT19 35
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nudt19 34
  • 48.46 (n)
zebrafish
(Danio rerio)
Actinopterygii nudt19 34 35
  • 52.52 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10194 34 35
  • 47.28 (n)
CG10195 35
  • 29 (a)
OneToMany
CG18094 35
  • 27 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009927 34
  • 44.34 (n)
worm
(Caenorhabditis elegans)
Secernentea ndx-7 34 35
  • 43.14 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 32 (a)
OneToOne
Species where no ortholog for NUDT19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUDT19 Gene

ENSEMBL:
Gene Tree for NUDT19 (if available)
TreeFam:
Gene Tree for NUDT19 (if available)

Paralogs for NUDT19 Gene

genes like me logo Genes that share paralogs with NUDT19: view

No data available for Paralogs for NUDT19 Gene

Variants for NUDT19 Gene

Sequence variations from dbSNP and Humsavar for NUDT19 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10412467 -- 32,691,824(+) CCAAA(C/T)GCCCA upstream-variant-2KB, utr-variant-5-prime
rs10413279 -- 32,691,840(+) ACCCA(A/G)CGCCA upstream-variant-2KB, utr-variant-5-prime
rs10413282 -- 32,691,845(+) ACGCC(A/G)GAGGC upstream-variant-2KB, utr-variant-5-prime
rs10418775 -- 32,701,478(+) caggc(A/G)tgagc intron-variant
rs10418819 -- 32,690,863(+) CGACC(A/G)CCTCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NUDT19 Gene

Variant ID Type Subtype PubMed ID
nsv1067189 CNV loss 25217958
nsv579311 CNV gain 21841781
nsv1127674 CNV deletion 24896259

Variation tolerance for NUDT19 Gene

Residual Variation Intolerance Score: 91.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.64; 78.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUDT19 Gene

Human Gene Mutation Database (HGMD)
NUDT19
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUDT19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT19 Gene

Disorders for NUDT19 Gene

Relevant External Links for NUDT19

Genetic Association Database (GAD)
NUDT19
Human Genome Epidemiology (HuGE) Navigator
NUDT19
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUDT19

No disorders were found for NUDT19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUDT19 Gene

Publications for NUDT19 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  2. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd B.J. … Pagliarini D.J. (Mol. Cell 2016) 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64
  5. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64

Products for NUDT19 Gene

Sources for NUDT19 Gene

Content
Loading form....