NUDT19 Gene
protein-coding GIFtS: 44
GCID: GC19P033182
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nudix (nucleoside diphosphate linked moiety X)-type motif...
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Aliases
for NUDT19 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 191 2 | | RP21 2 | | Nudix Motif 192 3 | | Nucleoside Diphosphate-Linked Moiety X Motif 19, Mitochondrial2 | | EC 3.6.1.-3 | | EC 3.6.18 |
Export aliases for NUDT19 gene to outside databasesPrevious GC identifers: GC19P037876 GC19P029686 |
Summaries
for NUDT19 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: NUD19_HUMAN, A8MXV4Function: Coenzyme A diphosphatase that mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoAand branched-chain fatty-acyl-CoA esters. At low substrate concentrations medium and long-chain fatty-acyl-CoA estersare the primary substrates (By similarity)
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Genomic Views
for NUDT19 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NUDT19 gene promoter:
Spz1 Pax-5 AML1a Sp1 p300 HNF-4alpha2 HNF-4alpha1 Pax-3 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for NUDT19
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUDT19 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.11 Ensembl cytogenetic band: 19q13.11 HGNC cytogenetic band: 19q13.11NUDT19 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P033182: view genomic region
(about GC identifiers)
Start:
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33,182,867 bp from pter |
End:
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33,204,702 bp from pter |
Size:
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21,836 bases |
Orientation:
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plus strand |
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Proteins
for NUDT19 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NUD19_HUMAN, A8MXV4 (See
protein sequence)Recommended Name: Nucleoside diphosphate-linked moiety X motif 19, mitochondrial precursor Size: 375 amino acids; 42233 Da
Cofactor: Magnesium or manganese (By similarity)
Subcellular location: Peroxisome (By similarity). Mitochondrion (By similarity)Explore the universe of human proteins at neXtProt for NUDT19: NX_A8MXV4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A8MXV4
4/6 DME Specific Peptides for NUDT19 (A8MXV4) (see all 6)
NUDT19 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001099040.1
ENSEMBL proteins: ENSP00000380251
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
NUDT19 for ontologies About GeneDecksing
NUDT19 Antibody Products:
Assay Products for NUDT19: |
Protein
Domains /
Families
for NUDT19 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NUDT19 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A8MXV4ProtoNet protein and cluster: A8MXV4 UniProtKB/Swiss-Prot: NUD19_HUMAN, A8MXV4Similarity: Belongs to the Nudix hydrolase familySimilarity: Contains 1 nudix hydrolase domain |
Function
for NUDT19 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NUD19_HUMAN, A8MXV4Function: Coenzyme A diphosphatase that mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoAand branched-chain fatty-acyl-CoA esters. At low substrate concentrations medium and long-chain fatty-acyl-CoA estersare the primary substrates (By similarity)Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.1.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT19 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT19 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for NUDT19 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NUDT19 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT19 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
NUDT19 for ontologies About GeneDecksing
Animal Models:
1 MGI phenotypic allele  for Nudt19 (no phenotypes)
NUDT19 for phenotypes About GeneDecksing
|
Pathways & Interactions
for NUDT19 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Peroxisome | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for NUDT19):
NUDT19 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NUDT19
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for NUDT19 (ENSP000003802514) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0008150 | biological_process |
ND | -- |
NUDT19 for ontologies About GeneDecksing
|
Drugs & Compounds
for NUDT19 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NUDT19
6 HMDB Compounds for NUDT19 About this table
Search CenterWatch for drugs/clinical trials and news about NUDT19 / NUD19
|
Transcripts
for NUDT19 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NUDT19 gene: NM_001105570.1 Unigene Cluster for NUDT19: Nudix (nucleoside diphosphate linked moiety X)-type motif 19 Hs.203961 [show with all ESTs]Unigene Representative Sequence: NM_0011055701 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000397061(uc010edf.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT19 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT19 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NUDT19 (NM_001105570) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NUDT19 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NUDT19 |
4 DOTS entries: DT.428808 DT.91656070 DT.110861 DT.92415103 23 AceView cDNA sequences: BQ775123 AA778432 BM750340 AI201404 CA438814 N79021 N33295 BM757860 BE904912 BM469626 BG470039 CK004811 N59083 BU175831 N26855 W19678 W19679 F31849 BG291421 CD700024 AW963217 AW809603 BF030198
GeneLoc Exon Structure
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Expression
for NUDT19 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NUDT19 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CATTGTACAA
About this image
See NUDT19 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NUDT19
SOURCE GeneReport for Unigene cluster: Hs.203961
SABiosciences Custom PCR Arrays for NUDT19
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUDT19
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NUDT19 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUDT19 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUDT19 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT19 |
Orthologs
for NUDT19 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for NUDT19 gene from 6/19 species (see all 19) About this table
ENSEMBL Gene Tree for NUDT19 (if available)
TreeFam Gene Tree for NUDT19 (if available) |
Paralogs
for NUDT19 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NUDT19 gene
NUDT19 for paralogs About GeneDecksing
5/6 Pseudogenes.org Pseudogenes for NUDT19 (see all 6)
PGOHUM00000246116 PGOHUM00000243333 PGOHUM00000243628 PGOHUM00000241232 PGOHUM00000241515
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Genomic Variants
for NUDT19 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NUDT19 (33182867 - 33204702 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NUDT19: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NUDT19 |
|
Disorders
/ Diseases
for NUDT19 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 NUDT19 for disorders About MalaCards
NUDT19 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: NUDT19 (1 document)
Export disorders for NUDT19 gene to outside databases
|
Publications
for NUDT19 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NUDT19 gene integrated from 9 sources:
(articles sorted by number of sources associating them with NUDT19) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Proteomic analysis of mouse kidney peroxisomes: identification of RP2p as a peroxisomal nudix hydrolase with acyl-CoA diphosphatase activity. (PubMed id 16185196)1 Ofman R....Wanders R.J. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
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External Searches for NUDT19 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NUDT19 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NUDT19 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NUDT19 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NUDT19 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for NUDT19 gene:
Search GeneIP for patents involving NUDT19
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NUDT19 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | NUDT19 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT19 |
|  |  |  | | | | Search ThermoFisher Antibodies for NUDT19 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NUDT19 |
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