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Aliases for NUDT18 Gene

Aliases for NUDT18 Gene

  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 18 2 3
  • Nucleoside Diphosphate-Linked Moiety X Motif 18 3 4
  • 7,8-Dihydro-8-Oxoguanine Phosphatase 3 4
  • 2-Hydroxy-DADP Phosphatase 3 4
  • MutT Human Homolog 3 2 3
  • MutT Homolog 3 3 4
  • Nudix Motif 18 3 4
  • MTH3 3 4
  • 8-Oxo-DGDP Phosphatase NUDT18 3
  • EC 3.6.1.58 4
  • EC 3.6.1 63

External Ids for NUDT18 Gene

Previous GeneCards Identifiers for NUDT18 Gene

  • GC08M022021
  • GC08M020506
  • GC08M021964

Summaries for NUDT18 Gene

Entrez Gene Summary for NUDT18 Gene

  • The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This protein contains a Nudix hydrolase domain and hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates. [provided by RefSeq, Sep 2012]

GeneCards Summary for NUDT18 Gene

NUDT18 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 18) is a Protein Coding gene. Among its related pathways are Metabolism and Purine metabolism (REACTOME). GO annotations related to this gene include magnesium ion binding and 8-oxo-GDP phosphatase activity.

UniProtKB/Swiss-Prot for NUDT18 Gene

  • Mediates the hydrolyzis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolyzis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT18 Gene

Genomics for NUDT18 Gene

Regulatory Elements for NUDT18 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NUDT18 Gene

Start:
22,106,872 bp from pter
End:
22,109,419 bp from pter
Size:
2,548 bases
Orientation:
Minus strand

Genomic View for NUDT18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUDT18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT18 Gene

Proteins for NUDT18 Gene

  • Protein details for NUDT18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZVK8-NUD18_HUMAN
    Recommended name:
    8-oxo-dGDP phosphatase NUDT18
    Protein Accession:
    Q6ZVK8
    Secondary Accessions:
    • Q8IZ75
    • Q9H687

    Protein attributes for NUDT18 Gene

    Size:
    323 amino acids
    Molecular mass:
    35501 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC85853.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NUDT18 Gene

    Alternative splice isoforms for NUDT18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUDT18 Gene

Proteomics data for NUDT18 Gene at MOPED

Selected DME Specific Peptides for NUDT18 Gene

Post-translational modifications for NUDT18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUDT18 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for NUDT18 Gene

Gene Families for NUDT18 Gene

HGNC:
  • NUDT :Nudix motif containing

Protein Domains for NUDT18 Gene

Suggested Antigen Peptide Sequences for NUDT18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZVK8

UniProtKB/Swiss-Prot:

NUD18_HUMAN :
  • Q6ZVK8
Domain:
  • Contains 1 nudix hydrolase domain.
Family:
  • Belongs to the Nudix hydrolase family.
genes like me logo Genes that share domains with NUDT18: view

Function for NUDT18 Gene

Molecular function for NUDT18 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=10.7 uM for 8-Oxo-dGDP {ECO:0000269 PubMed:22556419}; KM=11.7 uM for 8-Oxo-GDP {ECO:0000269 PubMed:22556419}; Vmax=212 pmol/min/ug enzyme toward 8-Oxo-dGDP (at 30 degrees Celsius) {ECO:0000269 PubMed:22556419}; Vmax=246 pmol/min/ug enzyme toward 8-Oxo-GDP (at 30 degrees Celsius) {ECO:0000269 PubMed:22556419}; pH dependence: Optimum pH is 8.5. {ECO:0000269 PubMed:22556419};
UniProtKB/Swiss-Prot CatalyticActivity: 8-oxo-dGDP + H(2)O = 8-oxo-dGMP + phosphate.
UniProtKB/Swiss-Prot Function: Mediates the hydrolyzis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolyzis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools.

Enzyme Numbers (IUBMB) for NUDT18 Gene

Gene Ontology (GO) - Molecular Function for NUDT18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 22556419
GO:0005515 protein binding IPI 16189514
GO:0016787 hydrolase activity --
GO:0044715 8-oxo-dGDP phosphatase activity IDA 22556419
GO:0044716 8-oxo-GDP phosphatase activity IDA 22556419
genes like me logo Genes that share ontologies with NUDT18: view

Animal Model Products

CRISPR Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NUDT18 Gene

Localization for NUDT18 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUDT18 Gene COMPARTMENTS Subcellular localization image for NUDT18 gene
Compartment Confidence
cytosol 4
nucleus 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for NUDT18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NUDT18: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NUDT18 Gene

Pathways for NUDT18 Gene

genes like me logo Genes that share pathways with NUDT18: view

Pathways by source for NUDT18 Gene

Gene Ontology (GO) - Biological Process for NUDT18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034656 nucleobase-containing small molecule catabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0046057 dADP catabolic process IDA 22556419
GO:0046067 dGDP catabolic process IDA 22556419
GO:0046712 GDP catabolic process IDA 22556419
genes like me logo Genes that share ontologies with NUDT18: view

Compounds for NUDT18 Gene

(6) HMDB Compounds for NUDT18 Gene

Compound Synonyms Cas Number PubMed IDs
ADP
  • adenosindiphosphorsaeure
58-64-0
CDP
  • CDP
63-38-7
dTDP
  • Deoxy-tdp
491-97-4
Guanosine diphosphate
  • 5'-GDP
146-91-8
Magnesium
  • Magnesium
7439-95-4
genes like me logo Genes that share compounds with NUDT18: view

Transcripts for NUDT18 Gene

mRNA/cDNA for NUDT18 Gene

(61) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NUDT18 Gene

Nudix (nucleoside diphosphate linked moiety X)-type motif 18:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NUDT18

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT18 Gene

No ASD Table

Relevant External Links for NUDT18 Gene

GeneLoc Exon Structure for
NUDT18
ECgene alternative splicing isoforms for
NUDT18

Expression for NUDT18 Gene

mRNA expression in normal human tissues for NUDT18 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for NUDT18 Gene

SOURCE GeneReport for Unigene cluster for NUDT18 Gene Hs.745387

genes like me logo Genes that share expressions with NUDT18: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NUDT18 Gene

Orthologs for NUDT18 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUDT18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUDT18 35
  • 99.9 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia NUDT18 35
  • 85.86 (n)
  • 84.83 (a)
dog
(Canis familiaris)
Mammalia NUDT18 35
  • 88.13 (n)
  • 87.93 (a)
mouse
(Mus musculus)
Mammalia Nudt18 35
  • 82.46 (n)
  • 81.42 (a)
Nudt18 16
rat
(Rattus norvegicus)
Mammalia Nudt18 35
  • 82.66 (n)
  • 82.35 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nudt18 35
  • 51.89 (n)
  • 46.33 (a)
zebrafish
(Danio rerio)
Actinopterygii nudt18 35
  • 54.14 (n)
  • 48.04 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002403 35
  • 54.68 (n)
  • 44.74 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10898 35
  • 51.49 (n)
  • 44.68 (a)
Species with no ortholog for NUDT18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUDT18 Gene

ENSEMBL:
Gene Tree for NUDT18 (if available)
TreeFam:
Gene Tree for NUDT18 (if available)

Paralogs for NUDT18 Gene

No data available for Paralogs for NUDT18 Gene

Variants for NUDT18 Gene

Sequence variations from dbSNP and Humsavar for NUDT18 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1005900 -- 22,107,050(-) CCTCT(C/T)CCCAG utr-variant-3-prime
rs1005901 -- 22,106,867(-) CCTCC(C/T)TGCCT downstream-variant-500B
rs1552285 -- 22,106,708(+) CAGCA(C/G)GCCAA downstream-variant-500B
rs1552286 -- 22,107,291(+) CCTCC(C/T)CCACC utr-variant-3-prime
rs2279354 -- 22,106,547(+) GGGAG(G/T)GGTCT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for NUDT18 Gene

Variant ID Type Subtype PubMed ID
essv19243 CNV CNV 17122850
essv21913 CNV CNV 17122850
dgv7756n71 CNV Loss 21882294
nsv831263 CNV Loss 17160897
nsv528590 CNV Loss 19592680
dgv7757n71 CNV Loss 21882294
nsv890654 CNV Loss 21882294
nsv465613 CNV Loss 19166990
dgv7758n71 CNV Loss 21882294
nsv890657 CNV Loss 21882294
nsv831264 CNV Gain+Loss 17160897
dgv450n21 CNV Loss 19592680
dgv881n27 CNV Loss 19166990
nsv470204 CNV Loss 18288195
nsv527293 CNV Loss 19592680

Relevant External Links for NUDT18 Gene

HapMap Linkage Disequilibrium report
NUDT18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT18 Gene

Disorders for NUDT18 Gene

No disorders were found for NUDT18 Gene.

No data available for UniProtKB/Swiss-Prot for NUDT18 Gene

Publications for NUDT18 Gene

  1. Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2. (PMID: 22556419) Takagi Y. … Sekiguchi M. (J. Biol. Chem. 2012) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for NUDT18 Gene

Sources for NUDT18 Gene

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