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Aliases for NUDT18 Gene

Aliases for NUDT18 Gene

  • Nudix Hydrolase 18 2 3 5
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 18 2 3
  • Nucleoside Diphosphate-Linked Moiety X Motif 18 3 4
  • 7,8-Dihydro-8-Oxoguanine Phosphatase 3 4
  • 2-Hydroxy-DADP Phosphatase 3 4
  • MutT Human Homolog 3 2 3
  • MutT Homolog 3 3 4
  • Nudix Motif 18 3 4
  • MTH3 3 4
  • 8-Oxo-DGDP Phosphatase NUDT18 3
  • EC 3.6.1.58 4
  • EC 3.6.1 61

External Ids for NUDT18 Gene

Previous GeneCards Identifiers for NUDT18 Gene

  • GC08M022021
  • GC08M020506
  • GC08M021964

Summaries for NUDT18 Gene

Entrez Gene Summary for NUDT18 Gene

  • The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This protein contains a Nudix hydrolase domain and hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates. [provided by RefSeq, Sep 2012]

GeneCards Summary for NUDT18 Gene

NUDT18 (Nudix Hydrolase 18) is a Protein Coding gene. Among its related pathways are Metabolism and Purine metabolism (REACTOME). GO annotations related to this gene include hydrolase activity and 8-oxo-dGDP phosphatase activity.

UniProtKB/Swiss-Prot for NUDT18 Gene

  • Mediates the hydrolyzis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolyzis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT18 Gene

Genomics for NUDT18 Gene

Regulatory Elements for NUDT18 Gene

Enhancers for NUDT18 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F022107 0.2 ENCODE 23.5 +0.8 795 3.4 HDGF PKNOX1 CREB3L1 ARID4B SIN3A ZNF2 ZNF143 ZNF207 FOS KLF13 NUDT18 GC08M022104
GH08F022102 0.5 ENCODE 23.4 +8.2 8191 0.2 POLR2H ZFHX2 ZNF316 POLR2A ZKSCAN8 HMBOX1 ZNF600 EMSY NR2C2 NUDT18 GC08M022104 FAM160B2
GH08F022103 0.6 ENCODE 22.6 +6.6 6553 1.7 ATF1 PKNOX1 ARNT SIN3A ZNF121 GATA2 NCOA1 CREB3 MEF2D MBD2 ENSG00000253200 NUDT18 GC08M022104 FAM160B2
GH08F022097 0.6 ENCODE 22.4 +15.0 14971 0.2 CTCF RFX1 KLF17 TRIM22 REST ZNF2 RAD21 ZFHX2 JUND ZBTB48 NUDT18 FAM160B2 GC08M022104
GH08F022117 0.9 Ensembl ENCODE 22.1 -7.6 -7609 1.1 KLF1 MAZ KLF17 NR3C1 ZIC2 JUND ZFHX2 GLIS2 POLR2A ZBTB48 NUDT18 GC08M022111 HR
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NUDT18 on UCSC Golden Path with GeneCards custom track

Promoters for NUDT18 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001387451 955 1601 HDGF PKNOX1 CREB3L1 ARID4B SIN3A ZNF2 ZNF143 ZNF207 FOS KLF13

Genomic Location for NUDT18 Gene

Chromosome:
8
Start:
22,106,872 bp from pter
End:
22,110,355 bp from pter
Size:
3,484 bases
Orientation:
Minus strand

Genomic View for NUDT18 Gene

Genes around NUDT18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDT18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDT18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT18 Gene

Proteins for NUDT18 Gene

  • Protein details for NUDT18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZVK8-NUD18_HUMAN
    Recommended name:
    8-oxo-dGDP phosphatase NUDT18
    Protein Accession:
    Q6ZVK8
    Secondary Accessions:
    • Q8IZ75
    • Q9H687

    Protein attributes for NUDT18 Gene

    Size:
    323 amino acids
    Molecular mass:
    35501 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC85853.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NUDT18 Gene

    Alternative splice isoforms for NUDT18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUDT18 Gene

Selected DME Specific Peptides for NUDT18 Gene

Q6ZVK8:
  • WYLPAGRME
  • QEAKREC

Post-translational modifications for NUDT18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUDT18 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for NUDT18 Gene

Gene Families for NUDT18 Gene

Suggested Antigen Peptide Sequences for NUDT18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZVK8

UniProtKB/Swiss-Prot:

NUD18_HUMAN :
  • Contains 1 nudix hydrolase domain.
  • Belongs to the Nudix hydrolase family.
Domain:
  • Contains 1 nudix hydrolase domain.
Family:
  • Belongs to the Nudix hydrolase family.
genes like me logo Genes that share domains with NUDT18: view

Function for NUDT18 Gene

Molecular function for NUDT18 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=10.7 uM for 8-Oxo-dGDP {ECO:0000269 PubMed:22556419}; KM=11.7 uM for 8-Oxo-GDP {ECO:0000269 PubMed:22556419}; Vmax=212 pmol/min/ug enzyme toward 8-Oxo-dGDP (at 30 degrees Celsius) {ECO:0000269 PubMed:22556419}; Vmax=246 pmol/min/ug enzyme toward 8-Oxo-GDP (at 30 degrees Celsius) {ECO:0000269 PubMed:22556419}; pH dependence: Optimum pH is 8.5. {ECO:0000269 PubMed:22556419};
UniProtKB/Swiss-Prot CatalyticActivity:
8-oxo-dGDP + H(2)O = 8-oxo-dGMP + phosphate.
UniProtKB/Swiss-Prot Function:
Mediates the hydrolyzis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolyzis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools.

Enzyme Numbers (IUBMB) for NUDT18 Gene

Gene Ontology (GO) - Molecular Function for NUDT18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 22556419
GO:0005515 protein binding IPI 16189514
GO:0016787 hydrolase activity IEA --
GO:0044715 8-oxo-dGDP phosphatase activity IDA 22556419
GO:0044716 8-oxo-GDP phosphatase activity IDA 22556419
genes like me logo Genes that share ontologies with NUDT18: view
genes like me logo Genes that share phenotypes with NUDT18: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUDT18 Gene

Localization for NUDT18 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUDT18 Gene COMPARTMENTS Subcellular localization image for NUDT18 gene
Compartment Confidence
cytosol 5
nucleus 4
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for NUDT18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NUDT18: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NUDT18 Gene

Pathways & Interactions for NUDT18 Gene

genes like me logo Genes that share pathways with NUDT18: view

Pathways by source for NUDT18 Gene

Gene Ontology (GO) - Biological Process for NUDT18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009117 nucleotide metabolic process IEA --
GO:0034656 nucleobase-containing small molecule catabolic process TAS --
GO:0046057 dADP catabolic process IDA 22556419
GO:0046067 dGDP catabolic process IDA 22556419
GO:0046712 GDP catabolic process IDA 22556419
genes like me logo Genes that share ontologies with NUDT18: view

No data available for SIGNOR curated interactions for NUDT18 Gene

Drugs & Compounds for NUDT18 Gene

(6) Drugs for NUDT18 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Manganese Approved Nutra 34
CDP Experimental Pharma 0
Guanosine diphosphate Experimental Pharma 0

(4) Additional Compounds for NUDT18 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
8-oxo-dGDP
8-Oxo-dGMP
  • 8-Oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate
  • 8OG
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
dTDP
  • Deoxy-TDP
  • Deoxythymidine 5'-diphosphate
  • dTDP
  • TDP
  • Thymidine 5'-diphosphate
491-97-4
genes like me logo Genes that share compounds with NUDT18: view

Transcripts for NUDT18 Gene

mRNA/cDNA for NUDT18 Gene

Unigene Clusters for NUDT18 Gene

Nudix (nucleoside diphosphate linked moiety X)-type motif 18:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT18 Gene

No ASD Table

Relevant External Links for NUDT18 Gene

GeneLoc Exon Structure for
NUDT18
ECgene alternative splicing isoforms for
NUDT18

Expression for NUDT18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NUDT18 Gene

Protein differential expression in normal tissues from HIPED for NUDT18 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.9), Spleen (11.2), Skin (6.9), and Lymph node (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NUDT18 Gene



Protein tissue co-expression partners for NUDT18 Gene

NURSA nuclear receptor signaling pathways regulating expression of NUDT18 Gene:

NUDT18

SOURCE GeneReport for Unigene cluster for NUDT18 Gene:

Hs.745387
genes like me logo Genes that share expression patterns with NUDT18: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NUDT18 Gene

Orthologs for NUDT18 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUDT18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUDT18 34
  • 99.9 (n)
dog
(Canis familiaris)
Mammalia NUDT18 34
  • 88.13 (n)
cow
(Bos Taurus)
Mammalia NUDT18 34
  • 85.86 (n)
rat
(Rattus norvegicus)
Mammalia Nudt18 34
  • 82.66 (n)
mouse
(Mus musculus)
Mammalia Nudt18 34 16
  • 82.46 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia nudt18 34
  • 51.89 (n)
zebrafish
(Danio rerio)
Actinopterygii nudt18 34
  • 54.14 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002403 34
  • 54.68 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10898 34
  • 51.49 (n)
Species where no ortholog for NUDT18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUDT18 Gene

ENSEMBL:
Gene Tree for NUDT18 (if available)
TreeFam:
Gene Tree for NUDT18 (if available)

Paralogs for NUDT18 Gene

No data available for Paralogs for NUDT18 Gene

Variants for NUDT18 Gene

Sequence variations from dbSNP and Humsavar for NUDT18 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1005900 -- 22,107,050(-) CCTCT(C/T)CCCAG utr-variant-3-prime
rs1005901 -- 22,106,867(-) CCTCC(C/T)TGCCT downstream-variant-500B
rs10091044 -- 22,110,587(+) TTGTA(C/G)AGCAG upstream-variant-2KB
rs10091698 -- 22,111,127(+) GCAAC(A/G)CAGGA upstream-variant-2KB
rs10101855 -- 22,110,344(+) CACCC(C/T)ACCTC upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for NUDT18 Gene

Variant ID Type Subtype PubMed ID
dgv12054n54 CNV loss 21841781
dgv12055n54 CNV loss 21841781
dgv450n21 CNV loss 19592680
dgv881n27 CNV loss 19166990
esv2759604 CNV loss 17122850
nsv465613 CNV loss 19166990
nsv470204 CNV loss 18288195
nsv527293 CNV loss 19592680
nsv528590 CNV loss 19592680
nsv610765 CNV loss 21841781
nsv831263 CNV loss 17160897
nsv831264 CNV gain+loss 17160897
nsv951112 CNV deletion 24416366

Variation tolerance for NUDT18 Gene

Gene Damage Index Score: 1.80; 33.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUDT18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUDT18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT18 Gene

Disorders for NUDT18 Gene

Relevant External Links for NUDT18

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUDT18

No disorders were found for NUDT18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUDT18 Gene

Publications for NUDT18 Gene

  1. Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2. (PMID: 22556419) Takagi Y. … Sekiguchi M. (J. Biol. Chem. 2012) 2 3 4 64
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  3. Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses. (PMID: 22458338) Simonis N. … Twizere J.C. (Retrovirology 2012) 3 64
  4. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PMID: 21044950) Lee O.H. … Songyang Z. (Mol. Cell Proteomics 2011) 3 64
  5. An empirical framework for binary interactome mapping. (PMID: 19060904) Venkatesan K. … Vidal M. (Nat. Methods 2009) 3 64

Products for NUDT18 Gene

Sources for NUDT18 Gene

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