Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



NUDT18 Gene

protein-coding   GIFtS: 45
GCID: GC08M021964

Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif...

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 181 2     7,8-Dihydro-8-Oxoguanine Phosphatase2 3
MutT Human Homolog 31 2     MTH32 3
MutT Homolog 32 3     8-Oxo-DGDP Phosphatase NUDT182
Nucleoside Diphosphate-Linked Moiety X Motif 182 3     EC 3.6.1.583
Nudix Motif 182 3     EC 3.6.18
2-Hydroxy-DADP Phosphatase2 3     

External Ids:    HGNC: 261941   Entrez Gene: 798732   Ensembl: ENSG000001735667   UniProtKB: Q6ZVK83   

Export aliases for NUDT18 gene to outside databases

Previous GC identifers: GC08M022021 GC08M020506


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for NUDT18 Gene:
The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially
toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different
nucleotide substrates, cofactors, and signaling molecules. This protein contains a Nudix hydrolase domain and
hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates. (provided by RefSeq, Sep 2012)

GeneCards Summary for NUDT18 Gene:
NUDT18 (nudix (nucleoside diphosphate linked moiety X)-type motif 18) is a protein-coding gene. GO annotations related to this gene include 8-oxo-GDP phosphatase activity and magnesium ion binding.

UniProtKB/Swiss-Prot: NUD18_HUMAN, Q6ZVK8
Function: Mediates the hydrolyzis of oxidized nucleoside diphosphate derivatives. Hydrolyzes
8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates.
Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP.
Exhibited no or minimal hydrolyzis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably
removes oxidized guanine nucleotides from both the DNA and RNA precursor pools




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the NUDT18 gene promoter:
         AhR   C/EBPbeta   Tal-1   Egr-1   Olf-1   Nkx2-5   NF-kappaB1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNUDT18 promoter sequence
   Search Chromatin IP Primers for NUDT18

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NUDT18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.3   Ensembl cytogenetic band:  8p21.3   HGNC cytogenetic band: 8p21.3

NUDT18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUDT18 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M021964:  view genomic region     (about GC identifiers)

Start:
21,964,383 bp from pter      End:
21,966,932 bp from pter
Size:
2,550 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NUD18_HUMAN, Q6ZVK8 (See protein sequence)
Recommended Name: 8-oxo-dGDP phosphatase NUDT18  
Size: 323 amino acids; 35501 Da
Cofactor: Manganese (By similarity). Magnesium
Sequence caution: Sequence=BAC85853.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
2 PDB 3D structures from and Proteopedia for NUDT18:
3GG6 (3D)        4HVY (3D)    
Secondary accessions: Q8IZ75 Q9H687
Alternative splicing: 2 isoforms:  Q6ZVK8-1   Q6ZVK8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NUDT18: NX_Q6ZVK8

Explore proteomics data for NUDT18 at MOPED

2 DME Specific Peptides for NUDT18 (Q6ZVK8)
 QEAKREC  WYLPAGRME 


See NUDT18 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_079091.3  
ENSEMBL proteins: 
 ENSP00000430539   ENSP00000429877   ENSP00000430117   ENSP00000307852  
Reactome Protein details: Q6ZVK8

NUDT18 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for NUDT18
OriGene Protein Over-expression Lysate for NUDT18
OriGene MassSpec for NUDT18
OriGene Custom Protein Services for NUDT18
GenScript Custom Purified and Recombinant Proteins Services for NUDT18
Novus Biologicals NUDT18 Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for NUDT18

 
Search eBioscience for Proteins for NUDT18 

 
antibodies-online proteins for NUDT18 (3 products) 

 
antibodies-online peptides for NUDT18

NUDT18 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
OriGene Antibodies for NUDT18
OriGene Custom Antibody Services for NUDT18
Novus Biologicals NUDT18 Antibodies
Abcam antibodies for NUDT18
Cloud-Clone Corp. Antibodies for NUDT18
Search ThermoFisher Antibodies for NUDT18
antibodies-online antibodies for NUDT18 (19 products) 

NUDT18 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for NUDT18
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for NUDT18
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for NUDT18
Cloud-Clone Corp. CLIAs for NUDT18
Search eBioscience for ELISAs for NUDT18 
antibodies-online kits for NUDT18 (6 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
HGNC Gene Families:
NUDT: Nudix motif containing

4 InterPro protein domains:
 IPR015797 NUDIX_hydrolase_dom-like
 IPR020476 Nudix_hydrolase
 IPR020084 NUDIX_hydrolase_CS
 IPR000086 NUDIX_hydrolase_dom

Graphical View of Domain Structure for InterPro Entry Q6ZVK8

ProtoNet protein and cluster: Q6ZVK8

1 Blocks protein domain: IPB000086 NUDIX hydrolase

UniProtKB/Swiss-Prot: NUD18_HUMAN, Q6ZVK8
Similarity: Belongs to the Nudix hydrolase family
Similarity: Contains 1 nudix hydrolase domain


Find genes that share domains with NUDT18           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: NUD18_HUMAN, Q6ZVK8
Function: Mediates the hydrolyzis of oxidized nucleoside diphosphate derivatives. Hydrolyzes
8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates.
Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP.
Exhibited no or minimal hydrolyzis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably
removes oxidized guanine nucleotides from both the DNA and RNA precursor pools
Catalytic activity: 8-oxo-dGDP + H(2)O = 8-oxo-dGMP + phosphate
Biophysicochemical properties: Kinetic parameters: KM=10.7 uM for 8-Oxo-dGDP; KM=11.7 uM for 8-Oxo-GDP; Vmax=212
pmol/min/ug enzyme toward 8-Oxo-dGDP (at 30 degrees Celsius); Vmax=246 pmol/min/ug enzyme toward 8-Oxo-GDP (at 30
degrees Celsius); pH dependence: Optimum pH is 8.5;

     Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.1.581

     Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000287magnesium ion binding IDA--
GO:0005515protein binding IPI16189514
GO:0016787hydrolase activity ----
GO:00447158-oxo-dGDP phosphatase activity IDA--
GO:00447168-oxo-GDP phosphatase activity IDA--
     
Find genes that share ontologies with NUDT18           About GenesLikeMe


Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for NUDT18

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat NUDT18 using miScript Target Protectors
4 qRT-PCR Assays for microRNAs that regulate NUDT18:
hsa-miR-512-5p hsa-miR-124 hsa-miR-506 hsa-miR-510
SwitchGear 3'UTR luciferase reporter plasmidNUDT18 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for NUDT18
Predesigned siRNA for gene silencing in human, mouse, rat NUDT18

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for NUDT18

Clone
Products:
     
OriGene clones in human, mouse for NUDT18 (see all 7)
OriGene ORF clones in mouse, rat for NUDT18
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: NUDT18 (NM_024815)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUDT18
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUDT18

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for NUDT18
Browse ESI BIO Cell Lines and PureStem Progenitors for NUDT18 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT18


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol4
nucleus3
golgi apparatus1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005829cytosol TAS--

Find genes that share ontologies with NUDT18           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for NUDT18 About    
See pathways by source

SuperPathContained pathways About
1Purine metabolism (REACTOME)
Metabolism of nucleotides0.42
Phosphate bond hydrolysis by NUDT proteins0.00
2Metabolism
Metabolism0.38


Find genes that share SuperPaths with NUDT18           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for NUDT18
    Phosphate bond hydrolysis by NUDT proteins


    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NUDT18
Interactions:

    Search GeneGlobe Interaction Network for NUDT18

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for NUDT18 (Q6ZVK81, 2, 3 ENSP000003078524) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
InteractantInteraction Details
GeneCardExternal ID(s)
APIPQ96GX91, 2, 3, ENSP000002783594EBI-740486,EBI-359248 MINT-66886 I2D: score=5 STRING: ENSP00000278359
DHPSP493661, 2, 3, ENSP000002100604EBI-740486,EBI-741925 MINT-66764 I2D: score=5 STRING: ENSP00000210060
HSD17B14Q9BPX11, 2, 3, ENSP000002632784EBI-740486,EBI-742664 MINT-67936 I2D: score=5 STRING: ENSP00000263278
PAICSP222341, 2, 3, ENSP000003825954EBI-740486,EBI-712261 MINT-68027 I2D: score=5 STRING: ENSP00000382595
DUTP333161, 2, 3, ENSP000003703764EBI-740486,EBI-353224 MINT-68046 I2D: score=4 STRING: ENSP00000370376
About this table

Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0034656nucleobase-containing small molecule catabolic process TAS--
GO:0044281small molecule metabolic process TAS--
GO:0046057dADP catabolic process IDA--
GO:0046067dGDP catabolic process IDA--
GO:0046712GDP catabolic process IDA--

Find genes that share ontologies with NUDT18           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for NUDT18 (NUD18)

6 HMDB Compounds for NUDT18    About this table
CompoundSynonyms CAS #PubMed Ids
ADPadenosindiphosphorsaeure (see all 8)58-64-0--
CDPCDP (see all 3)63-38-7--
Guanosine diphosphate5'-GDP (see all 10)146-91-8--
MagnesiumMagnesium (see all 2)7439-95-4--
Manganesemanganese 7439-96-5--
dTDPDeoxy-tdp (see all 5)491-97-4--



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for NUDT18 gene: 
NM_024815.3  

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000522405 ENST00000521807(uc003xar.1) ENST00000522379 ENST00000309188(uc003xaq.1)

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat NUDT18 using miScript Target Protectors
4 qRT-PCR Assays for microRNAs that regulate NUDT18:
hsa-miR-512-5p hsa-miR-124 hsa-miR-506 hsa-miR-510
SwitchGear 3'UTR luciferase reporter plasmidNUDT18 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for NUDT18
Predesigned siRNA for gene silencing in human, mouse, rat NUDT18
Clone
Products:
     
OriGene clones in human, mouse for NUDT18 (see all 7)
OriGene ORF clones in mouse, rat for NUDT18
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: NUDT18 (NM_024815)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUDT18
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUDT18
Primer
Products:
    
OriGene qPCR primer pairs and template standards for NUDT18
OriGene qSTAR qPCR primer pairs in human, mouse for NUDT18
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NUDT18
  QuantiTect SYBR Green Assays in human, mouse, rat NUDT18
  QuantiFast Probe-based Assays in human, mouse, rat NUDT18

Selected AceView cDNA sequences (see all 61):

CR622192 CR607168 BF437150 AK124446 BU684999 BX344375 CA313506 BG912319 
AI885403 BU164705 BC016902 BG764769 AA374925 BG697422 AI669189 BF939302 
BG764039 BM810518 CK299063 CF128006 AK026147 AL559394 AW291412 NM_024815 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

NUDT18 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GAGGGGCACT
NUDT18 Expression
About this image

NUDT18 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

NUDT18 Protein Expression
    Custom PCR Arrays for NUDT18
Primer
Products:
OriGene qPCR primer pairs and template standards for NUDT18
OriGene qSTAR qPCR primer pairs in human, mouse for NUDT18
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NUDT18
QuantiTect SYBR Green Assays in human, mouse, rat NUDT18
QuantiFast Probe-based Assays in human, mouse, rat NUDT18
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT18

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of animals.

Orthologs for NUDT18 gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Nudt181 , 5 nudix (nucleoside diphosphate linked moiety X)-type more1, 5 82.46(n)1
81.42(a)1
  14 (36.32 cM)5
2134841  NM_153136.41  NP_694776.21 
 705778475 
lizard
(Anolis carolinensis)
Reptilia NUDT186
nudix (nucleoside diphosphate linked moiety X)-typ...
50(a)
1 ↔ 1
GL343858.1(67990-72195)
tropical clawed frog
(Xenopus tropicalis)
Amphibia nudt181 nudix (nucleoside diphosphate linked moiety X)-type more 51.89(n)
46.33(a)
  100488091  XM_004912543.1  XP_004912600.1 
zebrafish
(Danio rerio)
Actinopterygii nudt181 nudix (nucleoside diphosphate linked moiety X)-type more 54.14(n)
48.04(a)
  550541  NM_001017843.1  NP_001017843.1 
fruit fly
(Drosophila melanogaster)
Insecta CG108981 CG10898 51.49(n)
44.68(a)
  41384  NM_141826.3  NP_650083.1 
worm
(Caenorhabditis elegans)
Secernentea ndx-16
Protein NDX-1 (ndx-1) mRNA, complete cds
26(a)
1 ↔ 1
I(12679211-12681815) WBGene00003578


ENSEMBL Gene Tree for NUDT18 (if available)
TreeFam Gene Tree for NUDT18 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for NUDT18 (see all 165)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 8 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs573160991,2
C--21966701(+) CAGCC-/CGCACG 2 C L fra11Minor allele frequency- C:0.00NA 2
rs583435761,2
C--21966708(+) ACGGG-/GCGCCG 2 C V fra11Minor allele frequency- G:0.00NA 2
rs559658061,2
C,F--21968887(+) TGTGTG/ATGTGT 1 -- us2k13Minor allele frequency- A:0.50NA 8
rs343942711,2
C--22217934(+) AAAAA-/AA/AAA
        
AAAAA
2 -- ds5001 cds11NA 2
rs1832877611,2
--22218040(+) GCCAGA/GGGGAG 1 -- ds50010--------
rs22793541,2
C,F,A--22218046(+) GGGAGG/TGGTCT 1 -- ds50016Minor allele frequency- T:0.43EA CSA WA NA 1666
rs783433071,2
C,F--22218054(+) TCTGCG/ACCAGG 1 -- ds50011Minor allele frequency- A:0.05WA 118
rs787279771,2
F--22218076(+) AGAGAG/ACAGAG 1 -- ds50011Minor allele frequency- A:0.02EA 120
rs604569151,2
C,F--22218152(+) GGGCTA/CAGAGC 1 -- ds50012Minor allele frequency- C:0.33WA CSA 3
rs1113372941,2
F--22218181(+) GGTCCC/TCTCAG 1 -- ds50011Minor allele frequency- T:0.50CSA 2

HapMap Linkage Disequilibrium report for NUDT18 (21964383 - 21966932 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for NUDT18 (see all 15):    About this table    
Variant IDTypeSubtypePubMed ID
nsv527293CNV Loss19592680
dgv7758n71CNV Loss21882294
dgv450n21CNV Loss19592680
nsv528590CNV Loss19592680
dgv881n27CNV Loss19166990
nsv465613CNV Loss19166990
dgv7756n71CNV Loss21882294
nsv470204CNV Loss18288195
dgv7757n71CNV Loss21882294
nsv890654CNV Loss21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing NUDT18
DNA2.0 Custom Variant and Variant Library Synthesis for NUDT18

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for NUDT18 gene, integrated from 10 sources (see all 11):
(articles sorted by number of sources associating them with NUDT18)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2. (PubMed id 22556419)1, 2, 3 Takagi Y.... Sekiguchi M. (J. Biol. Chem. 2012)
  2. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (amp 2011)
  3. An empirical framework for binary interactome mapping. (PubMed id 19060904)1 Venkatesan K....Vidal M. (Nat. Methods 2009)
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  6. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (Nature 2006)
  7. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (Cell 2006)
  8. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
  9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 79873 HGNC: 26194 AceView: FLJ22494 Ensembl:ENSG00000173566 euGenes: HUgn79873
ECgene: NUDT18 H-InvDB: NUDT18

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for NUDT18 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for NUDT18 gene:
Search GeneIP for patents involving NUDT18

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 OriGene Antibodies for NUDT18   OriGene RNAi products in human, mouse, rat for NUDT18  
 OriGene qPCR primer pairs and template standards for NUDT18   OriGene Protein Over-expression Lysate for NUDT18  
 OriGene MassSpec for NUDT18   OriGene clones in human, mouse for NUDT18  
 OriGene qSTAR qPCR primer pairs in human, mouse for NUDT18   OriGene Purified Protein for NUDT18  
 OriGene ORF clones in mouse, rat for NUDT18   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for NUDT18   OriGene Custom Protein Services for NUDT18  

 
 
 Block miRNA regulation of human, mouse, rat NUDT18 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NUDT18
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NUDT18 Predesigned siRNA for gene silencing in human, mouse, rat NUDT18
 QuantiFast Probe-based Assays in human, mouse, rat NUDT18 QuantiTect SYBR Green Assays in human, mouse, rat NUDT18
 Custom PCR Arrays for NUDT18 Search Chromatin IP Primers for NUDT18
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NUDT18  Search GeneGlobe Interaction Network for NUDT18
 Regulatory tfbs in NUDT18 promoter
 GenScript Custom Purified and Recombinant Proteins Services for NUDT18 GenScript cDNA clones with any tag delivered in your preferred vector for NUDT18
 GenScript Custom Assay Services for NUDT18 GenScript Custom overexpressing Cell Line Services for NUDT18
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for NUDT18 (NUD18)
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 NUDT18 antibodies
 NUDT18 lysates
 Antibodies for NUDT18
 See all of Abcam's Antibodies, Kits and Proteins for NUDT18
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Proteins for NUDT18
 Antibodies for NUDT18
 ELISAs for NUDT18
 CLIAs for NUDT18



 Browse ESI BIO Cell Lines and PureStem Progenitors for NUDT18
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT18
 SwitchGear 3'UTR luciferase reporter plasmids for NUDT18
 SwitchGear Promoter luciferase reporter plasmids for NUDT18
 Search ThermoFisher Antibodies for NUDT18
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUDT18
 Browse compounds at ApexBio
 Search Addgene for plasmids for NUDT18
  Search eBioscience for proteins for NUDT18
  Search eBioscience for elisas for NUDT18
  eBioscience FlowRNA Probe Sets
 genOway: Develop your customized and physiologically relevant rodent model for NUDT18
 antibodies-online antibodies for NUDT18 (19 products)
 antibodies-online kits for NUDT18 (6 products)
 antibodies-online peptides for NUDT18
 antibodies-online proteins for NUDT18 (3 products)
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      NUDT18 gene at Home site.
Version: 3.12.258 10 Dec 2014
hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4