Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NUDT17 Gene

Aliases for NUDT17 Gene

  • Nudix Hydrolase 17 2 3 5
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 17 2
  • Nucleoside Diphosphate-Linked Moiety X Motif 17 2
  • Nudix Motif 17 4
  • EC 3.6.1.- 4

External Ids for NUDT17 Gene

Previous GeneCards Identifiers for NUDT17 Gene

  • GC01M143075
  • GC01M144297
  • GC01M145586
  • GC01M119550

Summaries for NUDT17 Gene

GeneCards Summary for NUDT17 Gene

NUDT17 (Nudix Hydrolase 17) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity.

UniProtKB/Swiss-Prot for NUDT17 Gene

  • Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT17 Gene

Genomics for NUDT17 Gene

Regulatory Elements for NUDT17 Gene

Enhancers for NUDT17 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F145844 1.1 ENCODE 19.7 +0.9 873 1.9 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 KLF13 POLR3C NUDT17 ITGA10 PEX11B TXNIP CD160 PIAS3 MIR6736
GH01F145823 1.1 ENCODE 18.7 -20.6 -20643 1.7 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A YBX1 NUDT17 PIAS3 RNF115
GH01F145781 1.1 Ensembl ENCODE 17.8 -62.3 -62331 2.3 TBP INSM2 ZBTB40 ZEB1 RFX5 GTF3C2 POLR3A ZNF366 RCOR1 FOS POLR3C NUDT17 GNRHR2 PDZK1 CD160 PIAS3 ANKRD35 PIR35710 PIR40983
GH01F146034 1.5 Ensembl ENCODE 12.7 +192.6 192593 5.6 CREB3L1 MLX DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 TBX21 ZFP41 POLR3C NOTCH2NL ANKRD35 NUDT17 TXNIP GNRHR2 LINC01719 NBPF12 HFE2 TRG-TCC2-1
GH01F144997 1.4 Ensembl ENCODE 10.3 -845.5 -845482 4.2 PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF302 ZNF548 FOS ZNF263 POLR3C PFN1P6 NBPF25P ENSG00000224363 NUDT17 ENSG00000271644 FAM72D
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NUDT17 on UCSC Golden Path with GeneCards custom track

Promoters for NUDT17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000544270 815 1201 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 KLF13

Genomic Location for NUDT17 Gene

Chromosome:
1
Start:
145,844,985 bp from pter
End:
145,848,953 bp from pter
Size:
3,969 bases
Orientation:
Plus strand

Genomic View for NUDT17 Gene

Genes around NUDT17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDT17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDT17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT17 Gene

Proteins for NUDT17 Gene

  • Protein details for NUDT17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C025-NUD17_HUMAN
    Recommended name:
    Nucleoside diphosphate-linked moiety X motif 17
    Protein Accession:
    P0C025

    Protein attributes for NUDT17 Gene

    Size:
    328 amino acids
    Molecular mass:
    35923 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

neXtProt entry for NUDT17 Gene

Post-translational modifications for NUDT17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUDT17 Gene

No data available for DME Specific Peptides for NUDT17 Gene

Domains & Families for NUDT17 Gene

Gene Families for NUDT17 Gene

Protein Domains for NUDT17 Gene

Suggested Antigen Peptide Sequences for NUDT17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0C025

UniProtKB/Swiss-Prot:

NUD17_HUMAN :
  • Contains 1 nudix hydrolase domain.
  • Belongs to the Nudix hydrolase family.
Domain:
  • Contains 1 nudix hydrolase domain.
Family:
  • Belongs to the Nudix hydrolase family.
genes like me logo Genes that share domains with NUDT17: view

Function for NUDT17 Gene

Molecular function for NUDT17 Gene

UniProtKB/Swiss-Prot Function:
Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.

Enzyme Numbers (IUBMB) for NUDT17 Gene

Gene Ontology (GO) - Molecular Function for NUDT17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NUDT17: view

Phenotypes for NUDT17 Gene

GenomeRNAi human phenotypes for NUDT17:
genes like me logo Genes that share phenotypes with NUDT17: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NUDT17 Gene

Localization for NUDT17 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUDT17 gene
Compartment Confidence
extracellular 2
cytoskeleton 2
cytosol 2
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NUDT17 Gene

Pathways & Interactions for NUDT17 Gene

SuperPathways for NUDT17 Gene

No Data Available

Interacting Proteins for NUDT17 Gene

Gene Ontology (GO) - Biological Process for NUDT17 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NUDT17 Gene

Drugs & Compounds for NUDT17 Gene

(4) Drugs for NUDT17 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Approved Nutra 34
CDP Experimental Pharma 0
Guanosine diphosphate Experimental Pharma 0
Magnesium Nutra 0

(2) Additional Compounds for NUDT17 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
dTDP
  • Deoxy-TDP
  • Deoxythymidine 5'-diphosphate
  • dTDP
  • TDP
  • Thymidine 5'-diphosphate
491-97-4
genes like me logo Genes that share compounds with NUDT17: view

Transcripts for NUDT17 Gene

Unigene Clusters for NUDT17 Gene

Nudix (nucleoside diphosphate linked moiety X)-type motif 17:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT17 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6
SP1: -
SP2: - -
SP3:
SP4:

Relevant External Links for NUDT17 Gene

GeneLoc Exon Structure for
NUDT17
ECgene alternative splicing isoforms for
NUDT17

Expression for NUDT17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NUDT17 Gene

Protein differential expression in normal tissues from HIPED for NUDT17 Gene

This gene is overexpressed in Adipocyte (32.0), Spleen (21.7), and Kidney (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NUDT17 Gene



Protein tissue co-expression partners for NUDT17 Gene

NURSA nuclear receptor signaling pathways regulating expression of NUDT17 Gene:

NUDT17

SOURCE GeneReport for Unigene cluster for NUDT17 Gene:

Hs.585066
genes like me logo Genes that share expression patterns with NUDT17: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NUDT17 Gene

Orthologs for NUDT17 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NUDT17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUDT17 34 35
  • 98.68 (n)
dog
(Canis familiaris)
Mammalia NUDT17 34 35
  • 85.54 (n)
cow
(Bos Taurus)
Mammalia NUDT17 34 35
  • 85.08 (n)
mouse
(Mus musculus)
Mammalia Nudt17 34 16 35
  • 81.36 (n)
rat
(Rattus norvegicus)
Mammalia Nudt17 34
  • 80.92 (n)
oppossum
(Monodelphis domestica)
Mammalia NUDT17 35
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nudt17 34
  • 55.95 (n)
zebrafish
(Danio rerio)
Actinopterygii nudt17 34 35
  • 52.57 (n)
Species where no ortholog for NUDT17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUDT17 Gene

ENSEMBL:
Gene Tree for NUDT17 (if available)
TreeFam:
Gene Tree for NUDT17 (if available)

Paralogs for NUDT17 Gene

No data available for Paralogs for NUDT17 Gene

Variants for NUDT17 Gene

Sequence variations from dbSNP and Humsavar for NUDT17 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1050050 -- 145,848,712(+) AGCTT(C/T)TAGAG nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1050057 -- 145,848,665(+) CCTGG(A/C)AAGGT nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs10564953 -- 145,843,377(-) TATAA(-/AAC)AACAT upstream-variant-2KB, cds-indel
rs10590228 -- 145,843,215(-) TTCTA(-/CA)TACAC downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs10910829 -- 145,848,288(-) GGAGC(C/T)CTCCA intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for NUDT17 Gene

Variant ID Type Subtype PubMed ID
esv3572008 CNV gain 25503493
esv3587420 CNV gain 21293372
nsv1005055 CNV loss 25217958
nsv1015025 CNV gain 25217958
nsv831381 CNV gain 17160897

Variation tolerance for NUDT17 Gene

Residual Variation Intolerance Score: 77.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.24; 52.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUDT17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUDT17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT17 Gene

Disorders for NUDT17 Gene

Relevant External Links for NUDT17

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUDT17

No disorders were found for NUDT17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUDT17 Gene

Publications for NUDT17 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64
  4. Generation and analysis of 280,000 human expressed sequence tags. (PMID: 8889549) Hillier L.D. … Marra M. (Genome Res. 1996) 3 64

Products for NUDT17 Gene

Sources for NUDT17 Gene

Content
Loading form....