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NUDT17 Gene

protein-coding   GIFtS: 38
GCID: GC01M145586

Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif...

  Search for NUDT17
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 171 2
Nudix Motif 172 3
Nucleoside Diphosphate-Linked Moiety X Motif 172
EC 3.6.1.-3

External Ids:    HGNC: 266181   Entrez Gene: 2000352   Ensembl: ENSG000001863647   UniProtKB: P0C0253   

Export aliases for NUDT17 gene to outside databases

Previous GC identifers: GC01M143075 GC01M144297 GC01M119550


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NUDT17 Gene:
NUDT17 (nudix (nucleoside diphosphate linked moiety X)-type motif 17) is a protein-coding gene. GO annotations related to this gene include hydrolase activity.

UniProtKB/Swiss-Prot: NUD17_HUMAN, P0C025
Function: Probably mediates the hydrolysis of some nucleoside diphosphate derivatives (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NUDT17 gene promoter:
         Sox5   MAZR   Pax-2   Pax-2a   E47   GATA-1   YY1   AREB6   S8   FOXO4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNUDT17 promoter sequence
   Search Chromatin IP Primers for NUDT17

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NUDT17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.1   Ensembl cytogenetic band:  1q21.1   HGNC cytogenetic band: 1q21.1

NUDT17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUDT17 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M145586:  view genomic region     (about GC identifiers)

Start:
145,586,115 bp from pter      End:
145,589,439 bp from pter
Size:
3,325 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NUD17_HUMAN, P0C025 (See protein sequence)
Recommended Name: Nucleoside diphosphate-linked moiety X motif 17  
Size: 328 amino acids; 35923 Da
Cofactor: Magnesium or manganese (By similarity)

Explore the universe of human proteins at neXtProt for NUDT17: NX_P0C025

Explore proteomics data for NUDT17 at MOPED


See NUDT17 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001012776.1  
ENSEMBL proteins: 
 ENSP00000334437  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
NUDT: Nudix motif containing

2 InterPro protein domains:
 IPR015797 NUDIX_hydrolase_dom-like
 IPR000086 NUDIX_hydrolase_dom

Graphical View of Domain Structure for InterPro Entry P0C025

ProtoNet protein and cluster: P0C025

1 Blocks protein domain: IPB000086 NUDIX hydrolase

UniProtKB/Swiss-Prot: NUD17_HUMAN, P0C025
Similarity: Belongs to the Nudix hydrolase family
Similarity: Contains 1 nudix hydrolase domain


NUDT17 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: NUD17_HUMAN, P0C025
Function: Probably mediates the hydrolysis of some nucleoside diphosphate derivatives (By similarity)

     Enzyme Number (IUBMB): EC 3.6.1.-1

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016787hydrolase activity IEA--
GO:0046872metal ion binding IEA--
     
NUDT17 for ontologies           About GeneDecksing


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular2
cytoskeleton1
cytosol1
endoplasmic reticulum1
golgi apparatus1
lysosome1
mitochondrion1
nucleus1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NUDT17
Interactions:

    Search GeneGlobe Interaction Network for NUDT17

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for NUDT17 (NUD17)

6 HMDB Compounds for NUDT17    About this table
CompoundSynonyms CAS #PubMed Ids
ADPadenosindiphosphorsaeure (see all 8)58-64-0--
CDPCDP (see all 3)63-38-7--
Guanosine diphosphate5'-GDP (see all 10)146-91-8--
MagnesiumMagnesium (see all 2)7439-95-4--
Manganesemanganese 7439-96-5--
dTDPDeoxy-tdp (see all 5)491-97-4--



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for NUDT17 gene: 
NM_001012758.2  

Unigene Cluster for NUDT17:

Nudix (nucleoside diphosphate linked moiety X)-type motif 17
Hs.585066  [show with all ESTs]
Unigene Representative Sequence: BF689282
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000334513(uc001eoe.3) ENST00000498192 ENST00000477878 ENST00000444015
ENST00000460879
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Additional mRNA sequence: BC046352.1 

8 DOTS entries:

DT.444950  DT.95297810  DT.100794447  DT.65287596  DT.100794440  DT.102841683  DT.95073200  DT.100028671 

Selected AceView cDNA sequences (see all 253):

AA806817 AY091463 BM806769 CB143033 BF515674 AA830644 AW007157 AA552020 
BX395308 BC002586 AA906250 BM978381 AA134612 AA146669 BU742449 AA582676 
BQ688306 BI907327 BM727922 AI357793 BC004424 BX336126 CR608817 BM556814 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for NUDT17    About this scheme

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6
SP1:              -                                             
SP2:              -     -                                       
SP3:                                                            
SP4:                                                            


ECgene alternative splicing isoforms for NUDT17

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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NUDT17 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
NUDT17 Expression
About this image

NUDT17 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

NUDT17 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.585066
    Custom PCR Arrays for NUDT17
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for NUDT17 gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Nudt171 , 5 nudix (nucleoside diphosphate linked moiety X)-type more1, 5 81.36(n)1
72.2(a)1
  3 (41.95 cM)5
783731  NM_030094.11  NP_084370.11 
 967058925 
tropical clawed frog
(Xenopus tropicalis)
Amphibia nudt171 nudix (nucleoside diphosphate linked moiety X)-type more 55.95(n)
50.45(a)
  496685  XM_002939503.2  XP_002939549.2 
zebrafish
(Danio rerio)
Actinopterygii nudt171 nudix (nucleoside diphosphate linked moiety X)-type more 52.57(n)
49.01(a)
  556651  NM_001030103.1  NP_001025274.1 


ENSEMBL Gene Tree for NUDT17 (if available)
TreeFam Gene Tree for NUDT17 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for NUDT17 (see all 113)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1852603411,2
--145587234(+) CCCACG/TCTCCT 1 -- int10--------
rs1463839521,2
--145587244(+) TTAAAA/TCTCCC 1 -- int10--------
rs1901604361,2
--145587256(+) CACAAC/TACAAA 1 -- int10--------
rs2022278251,2
--145587314(+) TGTTGC/GTGTAT 1 -- int10--------
rs1395284491,2
C,F--145587383(+) AAGTCC/TGGGTG 2 R G mis11Minor allele frequency- T:0.00NA 4552
rs761414481,2
C--145587403(+) CATCCC/TCTGCG 2 E G mis10--------
rs2011034221,2
--145587436(+) CTGGTA/GTCAGC 2 T I mis10--------
rs1427174001,2
C,F--145587453(+) AGGGCG/ACTCAC 2 /S syn11Minor allele frequency- A:0.02NA 4550
rs2014029561,2
C--145587481(+) GGATCC/TGGGCC 2 Q R mis10--------
rs2006922611,2
--145587491(+) CTGGGA/GTCAGA 1 -- int10--------

HapMap Linkage Disequilibrium report for NUDT17 (145586115 - 145589439 bp)

Structural Variations
     Database of Genomic Variants (DGV) 8 variations for NUDT17:    About this table    
Variant IDTypeSubtypePubMed ID
dgv15n16CNV Deletion17901297
dgv46e201CNV Deletion23290073
esv2422428CNV Duplication17116639
nsv872232CNV Gain21882294
dgv347n71CNV Gain21882294
nsv831381CNV Gain17160897
nsv831370CNV Gain17160897
nsv7181OTHER Inversion18451855

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for NUDT17 gene integrated from 10 sources:
(articles sorted by number of sources associating them with NUDT17)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
  4. Generation and analysis of 280,000 human expressed sequence tags. (PubMed id 8889549)1 Hillier L.D....Marra M. (Genome Res. 1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 200035 HGNC: 26618 AceView: POLR3CandFLJ34433 Ensembl:ENSG00000186364 euGenes: HUgn200035
ECgene: NUDT17 H-InvDB: NUDT17

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for NUDT17 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for NUDT17 gene:
Search GeneIP for patents involving NUDT17

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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