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Aliases for NUDT16L1 Gene

Aliases for NUDT16L1 Gene

  • Nudix Hydrolase 16 Like 1 2 3 5
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 16-Like 1 2 3
  • NUDT16-Like Protein 1 3 4
  • Syndesmos 2 3
  • SDOS 3 4
  • Protein Syndesmos 3

External Ids for NUDT16L1 Gene

Previous GeneCards Identifiers for NUDT16L1 Gene

  • GC16P004684
  • GC16P004743

Summaries for NUDT16L1 Gene

GeneCards Summary for NUDT16L1 Gene

NUDT16L1 (Nudix Hydrolase 16 Like 1) is a Protein Coding gene. Among its related pathways are Syndecan-4-mediated signaling events and Proteoglycans in cancer. GO annotations related to this gene include poly(A) RNA binding and hydrolase activity. An important paralog of this gene is NUDT16.

UniProtKB/Swiss-Prot for NUDT16L1 Gene

  • Probable adapter protein, which may link syndecan-4 (SDC4) and paxilin (TGFB1I1 and PXN) receptors (By similarity). Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT16L1 Gene

Genomics for NUDT16L1 Gene

Regulatory Elements for NUDT16L1 Gene

Enhancers for NUDT16L1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G004658 1.8 FANTOM5 Ensembl ENCODE dbSUPER 13 -31.0 -31006 7.3 FOXA2 MLX ARID4B DMAP1 ZNF48 YY1 TCF12 SLC30A9 FOS SP5 MGRN1 NUDT16L1 PPL SEPT12 CORO7 GLYR1 NAGPA ENSG00000278700 MIR6769A
GH16G004473 1.4 ENCODE dbSUPER 10.5 -217.4 -217390 5.4 MLX CREB3L1 AGO1 DMAP1 ZNF143 ZNF548 ZNF263 SP3 NFYC GLIS1 NMRAL1 ZNF500 CREBBP CDIP1 HMOX2 NUDT16L1 MGRN1
GH16G004639 1.2 Ensembl ENCODE dbSUPER 11.9 -53.2 -53202 2.5 PAF1 ZSCAN4 MNT ZIC2 ZFHX2 POLR2A SCRT2 MYNN PRDM10 EGR2 NUDT16L1 ZNF500 NMRAL1 MGRN1 CDIP1 ENSG00000261442 RN7SL850P
GH16G004649 1.2 ENCODE dbSUPER 11.8 -43.0 -42957 1.3 ARID4B SIN3A ZNF2 ZNF207 ZNF143 FOS YY2 ZHX2 MIER2 PPARG NUDT16L1 ENSG00000278700 ENSG00000261442
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NUDT16L1 on UCSC Golden Path with GeneCards custom track

Promoters for NUDT16L1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for NUDT16L1 Gene

4,693,558 bp from pter
4,695,859 bp from pter
2,302 bases
Plus strand

Genomic View for NUDT16L1 Gene

Genes around NUDT16L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDT16L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDT16L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT16L1 Gene

Proteins for NUDT16L1 Gene

  • Protein details for NUDT16L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein syndesmos
    Protein Accession:
    Secondary Accessions:
    • Q8NAI2

    Protein attributes for NUDT16L1 Gene

    211 amino acids
    Molecular mass:
    23338 Da
    Quaternary structure:
    • Interacts with the cytoplasmic part of SDC4. Interacts with TGFB1I1 and PXN (By similarity).
    • Although strongly related to the nudix NUDT16 protein, it lacks the Nudix box and is therefore not related to the rest of the family. Gene organization and evolutionary distribution suggest that syndesmos NUDT16L1 probably originated as a gene duplication event of the more ancient U8 snoRNA-decapping enzyme NUDT16.

    Three dimensional structures from OCA and Proteopedia for NUDT16L1 Gene

    Alternative splice isoforms for NUDT16L1 Gene


neXtProt entry for NUDT16L1 Gene

Post-translational modifications for NUDT16L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUDT16L1 Gene

No data available for DME Specific Peptides for NUDT16L1 Gene

Domains & Families for NUDT16L1 Gene

Gene Families for NUDT16L1 Gene

Protein Domains for NUDT16L1 Gene


Suggested Antigen Peptide Sequences for NUDT16L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NUDT16L1: view

No data available for UniProtKB/Swiss-Prot for NUDT16L1 Gene

Function for NUDT16L1 Gene

Molecular function for NUDT16L1 Gene

UniProtKB/Swiss-Prot Function:
Probable adapter protein, which may link syndecan-4 (SDC4) and paxilin (TGFB1I1 and PXN) receptors (By similarity). Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.

Gene Ontology (GO) - Molecular Function for NUDT16L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22681889
GO:0005515 protein binding IPI 25416956
GO:0016787 hydrolase activity IEA --
GO:0030515 snoRNA binding IDA 18820299
GO:0042803 NOT protein homodimerization activity IDA 18820299
genes like me logo Genes that share ontologies with NUDT16L1: view

Phenotypes for NUDT16L1 Gene

GenomeRNAi human phenotypes for NUDT16L1:
genes like me logo Genes that share phenotypes with NUDT16L1: view

Animal Model Products

CRISPR Products

miRNA for NUDT16L1 Gene

miRTarBase miRNAs that target NUDT16L1

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUDT16L1 Gene

Localization for NUDT16L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDT16L1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUDT16L1 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
peroxisome 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NUDT16L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 28241136
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NUDT16L1: view

Pathways & Interactions for NUDT16L1 Gene

genes like me logo Genes that share pathways with NUDT16L1: view

Pathways by source for NUDT16L1 Gene

1 BioSystems pathway for NUDT16L1 Gene
1 KEGG pathway for NUDT16L1 Gene

Gene Ontology (GO) - Biological Process for NUDT16L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:2001033 negative regulation of double-strand break repair via nonhomologous end joining IDA 28241136
genes like me logo Genes that share ontologies with NUDT16L1: view

No data available for SIGNOR curated interactions for NUDT16L1 Gene

Drugs & Compounds for NUDT16L1 Gene

No Compound Related Data Available

Transcripts for NUDT16L1 Gene

Unigene Clusters for NUDT16L1 Gene

Nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT16L1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b
SP2: -

Relevant External Links for NUDT16L1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NUDT16L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUDT16L1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NUDT16L1 Gene

Protein tissue co-expression partners for NUDT16L1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NUDT16L1 Gene:


SOURCE GeneReport for Unigene cluster for NUDT16L1 Gene:


Evidence on tissue expression from TISSUES for NUDT16L1 Gene

  • Lung(4.3)
  • Nervous system(3)
genes like me logo Genes that share expression patterns with NUDT16L1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUDT16L1 Gene

Orthologs for NUDT16L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NUDT16L1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NUDT16L1 34 35
  • 99.84 (n)
(Bos Taurus)
Mammalia NUDT16L1 34 35
  • 92.42 (n)
(Canis familiaris)
Mammalia NUDT16L1 34 35
  • 88.52 (n)
(Rattus norvegicus)
Mammalia Nudt16l1 34
  • 86.89 (n)
(Mus musculus)
Mammalia Nudt16l1 34 16 35
  • 85.47 (n)
(Ornithorhynchus anatinus)
Mammalia NUDT16L1 35
  • 84 (a)
(Monodelphis domestica)
Mammalia NUDT16L1 35
  • 72 (a)
(Gallus gallus)
Aves NUDT16L1 34
  • 79.9 (n)
  • 51 (a)
(Danio rerio)
Actinopterygii zgc:103759 35
  • 38 (a)
FP015790.3 35
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3699 35
  • 28 (a)
Species where no ortholog for NUDT16L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUDT16L1 Gene

Gene Tree for NUDT16L1 (if available)
Gene Tree for NUDT16L1 (if available)

Paralogs for NUDT16L1 Gene

Paralogs for NUDT16L1 Gene

(1) SIMAP similar genes for NUDT16L1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NUDT16L1: view

Variants for NUDT16L1 Gene

Sequence variations from dbSNP and Humsavar for NUDT16L1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000365632 -- 4,695,990(+) CAGCA(C/T)GAATG downstream-variant-500B
rs1000377771 -- 4,689,357(+) GGTCA(A/G)TGAAG nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs1000707762 -- 4,691,478(+) CCGTA(C/T)AAGGT utr-variant-5-prime
rs1000802110 -- 4,695,812(+) TGTCG(A/G)AGGAG utr-variant-3-prime
rs1000987160 -- 4,692,016(+) AGAAG(A/G)CTGCC upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for NUDT16L1 Gene

Variant ID Type Subtype PubMed ID
nsv1046986 CNV gain 25217958
nsv1050237 CNV loss 25217958
nsv1160333 CNV deletion 26073780

Variation tolerance for NUDT16L1 Gene

Residual Variation Intolerance Score: 37.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.46; 10.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUDT16L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT16L1 Gene

Disorders for NUDT16L1 Gene

Relevant External Links for NUDT16L1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NUDT16L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUDT16L1 Gene

Publications for NUDT16L1 Gene

  1. Evolutionary conservation supports ancient origin for Nudt16, a nuclear-localized, RNA-binding, RNA-decapping enzyme. (PMID: 18820299) Taylor M.J. … Peculis B.A. (Nucleic Acids Res. 2008) 2 3 4 64
  2. Multiple mRNA decapping enzymes in mammalian cells. (PMID: 21070968) Song M.G. … Kiledjian M. (Mol. Cell 2010) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Syndesmos, a syndecan-4 cytoplasmic domain interactor, binds to the focal adhesion adaptor proteins paxillin and Hic-5. (PMID: 11805099) Denhez F. … Goetinck P.F. (J. Biol. Chem. 2002) 2 3 64

Products for NUDT16L1 Gene

Sources for NUDT16L1 Gene

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