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Aliases for NUDT16L1 Gene

Aliases for NUDT16L1 Gene

  • Nudix Hydrolase 16 Like 1 2 3 5
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 16-Like 1 2 3
  • NUDT16-Like Protein 1 3 4
  • Syndesmos 2 3
  • SDOS 3 4

External Ids for NUDT16L1 Gene

Previous GeneCards Identifiers for NUDT16L1 Gene

  • GC16P004684
  • GC16P004743

Summaries for NUDT16L1 Gene

GeneCards Summary for NUDT16L1 Gene

NUDT16L1 (Nudix Hydrolase 16 Like 1) is a Protein Coding gene. Among its related pathways are Proteoglycans in cancer and Syndecan-4-mediated signaling events. GO annotations related to this gene include poly(A) RNA binding and hydrolase activity. An important paralog of this gene is NUDT16.

UniProtKB/Swiss-Prot for NUDT16L1 Gene

  • Probable adapter protein, which may link syndecan-4 (SDC4) and paxilin (TGFB1I1 and PXN) receptors (By similarity). Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT16L1 Gene

Genomics for NUDT16L1 Gene

Regulatory Elements for NUDT16L1 Gene

Promoters for NUDT16L1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NUDT16L1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NUDT16L1 Gene

Chromosome:
16
Start:
4,693,558 bp from pter
End:
4,695,859 bp from pter
Size:
2,302 bases
Orientation:
Plus strand

Genomic View for NUDT16L1 Gene

Genes around NUDT16L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDT16L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDT16L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT16L1 Gene

Proteins for NUDT16L1 Gene

  • Protein details for NUDT16L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRJ7-SDOS_HUMAN
    Recommended name:
    Protein syndesmos
    Protein Accession:
    Q9BRJ7
    Secondary Accessions:
    • Q8NAI2

    Protein attributes for NUDT16L1 Gene

    Size:
    211 amino acids
    Molecular mass:
    23338 Da
    Quaternary structure:
    • Interacts with the cytoplasmic part of SDC4. Interacts with TGFB1I1 and PXN (By similarity).
    Miscellaneous:
    • Although strongly related to the nudix NUDT16 protein, it lacks the Nudix box and is therefore not related to the rest of the family. Gene organization and evolutionary distribution suggest that syndesmos NUDT16L1 probably originated as a gene duplication event of the more ancient U8 snoRNA-decapping enzyme NUDT16.

    Three dimensional structures from OCA and Proteopedia for NUDT16L1 Gene

    Alternative splice isoforms for NUDT16L1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUDT16L1 Gene

Proteomics data for NUDT16L1 Gene at MOPED

Post-translational modifications for NUDT16L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUDT16L1 Gene

No data available for DME Specific Peptides for NUDT16L1 Gene

Domains & Families for NUDT16L1 Gene

Gene Families for NUDT16L1 Gene

Protein Domains for NUDT16L1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NUDT16L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NUDT16L1: view

No data available for UniProtKB/Swiss-Prot for NUDT16L1 Gene

Function for NUDT16L1 Gene

Molecular function for NUDT16L1 Gene

UniProtKB/Swiss-Prot Function:
Probable adapter protein, which may link syndecan-4 (SDC4) and paxilin (TGFB1I1 and PXN) receptors (By similarity). Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.

Gene Ontology (GO) - Molecular Function for NUDT16L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016787 hydrolase activity IEA --
GO:0042803 NOT protein homodimerization activity IDA 18820299
GO:0044822 poly(A) RNA binding IDA 22681889
GO:0050072 NOT m7G(5)pppN diphosphatase activity ISS --
genes like me logo Genes that share ontologies with NUDT16L1: view

Phenotypes for NUDT16L1 Gene

GenomeRNAi human phenotypes for NUDT16L1:
genes like me logo Genes that share phenotypes with NUDT16L1: view

Animal Model Products

CRISPR Products

miRNA for NUDT16L1 Gene

miRTarBase miRNAs that target NUDT16L1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUDT16L1 Gene

Localization for NUDT16L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDT16L1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUDT16L1 Gene COMPARTMENTS Subcellular localization image for NUDT16L1 gene
Compartment Confidence
cytosol 3
nucleus 2
peroxisome 2
plasma membrane 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for NUDT16L1 Gene

Pathways & Interactions for NUDT16L1 Gene

genes like me logo Genes that share pathways with NUDT16L1: view

Pathways by source for NUDT16L1 Gene

1 BioSystems pathway for NUDT16L1 Gene
1 KEGG pathway for NUDT16L1 Gene

Gene Ontology (GO) - Biological Process for NUDT16L1 Gene

None

No data available for SIGNOR curated interactions for NUDT16L1 Gene

Drugs & Compounds for NUDT16L1 Gene

No Compound Related Data Available

Transcripts for NUDT16L1 Gene

Unigene Clusters for NUDT16L1 Gene

Nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT16L1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -
SP3:

Relevant External Links for NUDT16L1 Gene

GeneLoc Exon Structure for
NUDT16L1
ECgene alternative splicing isoforms for
NUDT16L1

Expression for NUDT16L1 Gene

mRNA expression in normal human tissues for NUDT16L1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUDT16L1 Gene



SOURCE GeneReport for Unigene cluster for NUDT16L1 Gene Hs.513315

genes like me logo Genes that share expression patterns with NUDT16L1: view

Protein tissue co-expression partners for NUDT16L1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NUDT16L1 Gene

Orthologs for NUDT16L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NUDT16L1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NUDT16L1 35
  • 92.42 (n)
  • 97.16 (a)
NUDT16L1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUDT16L1 35
  • 88.52 (n)
  • 91.39 (a)
NUDT16L1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nudt16l1 35
  • 85.47 (n)
  • 95.73 (a)
Nudt16l1 16
Nudt16l1 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NUDT16L1 35
  • 99.84 (n)
  • 100 (a)
NUDT16L1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nudt16l1 35
  • 86.89 (n)
  • 96.21 (a)
oppossum
(Monodelphis domestica)
Mammalia NUDT16L1 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUDT16L1 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUDT16L1 35
  • 79.9 (n)
  • 79.9 (a)
SDOS 36
  • 51 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii FP015790.3 36
  • 30 (a)
ManyToMany
zgc:103759 36
  • 38 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3699 36
  • 28 (a)
OneToMany
Species with no ortholog for NUDT16L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUDT16L1 Gene

ENSEMBL:
Gene Tree for NUDT16L1 (if available)
TreeFam:
Gene Tree for NUDT16L1 (if available)

Paralogs for NUDT16L1 Gene

Paralogs for NUDT16L1 Gene

(1) SIMAP similar genes for NUDT16L1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NUDT16L1: view

Variants for NUDT16L1 Gene

Sequence variations from dbSNP and Humsavar for NUDT16L1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs841218 -- 4,692,978(-) CTGGA(C/G)CTTTC upstream-variant-2KB
rs841219 -- 4,691,635(-) CCAGC(A/G)CCCTT upstream-variant-2KB
rs1043722 -- 4,695,742(+) GCTTC(A/C)CCCCA utr-variant-3-prime
rs2291407 -- 4,693,792(+) GGGCC(A/G)GGCTG reference, synonymous-codon
rs8057392 -- 4,694,684(+) GTGGA(C/T)GGGGG intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NUDT16L1 Gene

Variant ID Type Subtype PubMed ID
dgv2587n71 CNV Loss 21882294
dgv2588n71 CNV Loss 21882294
dgv2589n71 CNV Loss 21882294
nsv905243 CNV Loss 21882294
dgv2590n71 CNV Loss 21882294
nsv905248 CNV Loss 21882294
nsv905249 CNV Loss 21882294

Variation tolerance for NUDT16L1 Gene

Residual Variation Intolerance Score: 37.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.46; 10.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUDT16L1 Gene

HapMap Linkage Disequilibrium report
NUDT16L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT16L1 Gene

Disorders for NUDT16L1 Gene

Relevant External Links for NUDT16L1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUDT16L1

No disorders were found for NUDT16L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUDT16L1 Gene

Publications for NUDT16L1 Gene

  1. Evolutionary conservation supports ancient origin for Nudt16, a nuclear-localized, RNA-binding, RNA-decapping enzyme. (PMID: 18820299) Taylor M.J. … Peculis B.A. (Nucleic Acids Res. 2008) 2 3 4 67
  2. Syndesmos, a syndecan-4 cytoplasmic domain interactor, binds to the focal adhesion adaptor proteins paxillin and Hic-5. (PMID: 11805099) Denhez F. … Goetinck P.F. (J. Biol. Chem. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  5. Identifying biological pathways that underlie primordial short stature using network analysis. (PMID: 24711643) Hanson D. … Clayton P.E. (J. Mol. Endocrinol. 2014) 3

Products for NUDT16L1 Gene

Sources for NUDT16L1 Gene

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