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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NUDT16 Gene

protein-coding   GIFtS: 49
GCID: GC03P131100

Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 161 2     M7GpppN-MRNA Hydrolase2 3
Inosine Diphosphate Phosphatase2 3     U8 SnoRNA-Binding Protein H29K2 3
Nucleoside Diphosphate-Linked Moiety X Motif 162 3     U8 SnoRNA-Decapping Enzyme2
Nudix Motif 162 3     EC 3.6.1.-3
IDPase2 3     EC 3.6.1.623
IDP Phosphatase2 3     EC 3.6.18

External Ids:    HGNC: 264421   Entrez Gene: 1318702   Ensembl: ENSG000001985857   UniProtKB: Q96DE03   
ORGUL members:         
NONCODE14:n409150 n342542      

Export aliases for NUDT16 gene to outside databases

Previous GC identifers: GC03P132584 GC03P128485


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NUDT16 Gene: 
NUDT16 (nudix (nucleoside diphosphate linked moiety X)-type motif 16) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with NUDT16 include intrahepatic cholangiocarcinoma, and cholangiocarcinoma, and among its related super-pathways are Deadenylation-dependent mRNA decay and Purine metabolism. GO annotations related to this gene include magnesium ion binding and protein homodimerization activity. An important paralog of this gene is NUDT16L1.

UniProtKB/Swiss-Prot: NUD16_HUMAN, Q96DE0
Function: RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs
in a metal-dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S
and 28S rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a
5'monophosphate on the RNA. Catalyzes also the cleavage of the cap structure on mRNAs. Does not hydrolyze cap
analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG). Also hydrolysis m7G- and m227G
U3-capped RNAs but with less efficiencies. Has broad substrate specificity with manganese or cobalt as cofactor
and can act on various RNA species. Binds to the U8 snoRNA; metal is not required for RNA-binding. May play a
role in the regulation of snoRNAs and mRNAs degradation. Acts also as a phosphatase; hydrolyzes the non-canonical
purine nucleotides inosine diphosphate (IDP) and deoxyinosine diphosphate (dITP) as well as guanosine diphosphate
(GDP), deoxyguanosine diphosphate (dGDP), xanthine diphosphate (XDP), inosine triphosphate (ITP) and deoxyinosine
triphosphate (ITP) to their respective monophosphate derivatives and does not distinguish between the deoxy- and
ribose forms. The order of activity with different substrates is IDP > dIDP >> GDP = dGDP > XDP = ITP = dITP.
Binds strongly to GTP, ITP and XTP. Participates in the hydrolysis of dIDP/IDP and probably excludes
non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and
avoiding chromosomal lesions




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NUDT16 gene promoter:
         MAZR   p53   AP-4   GATA-1   RORalpha2   GATA-2   CREB   STAT3   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNUDT16 promoter sequence
   Search SABiosciences Chromatin IP Primers for NUDT16

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUDT16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22.1   Ensembl cytogenetic band:  3q22.1   HGNC cytogenetic band: 3q21.3

NUDT16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUDT16 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P131100:  view genomic region     (about GC identifiers)

Start:
131,100,515 bp from pter      End:
131,107,674 bp from pter
Size:
7,160 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for NUDT16

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NUD16_HUMAN, Q96DE0 (See protein sequence)
Recommended Name: U8 snoRNA-decapping enzyme  
Size: 195 amino acids; 21273 Da
Cofactor: Magnesium, manganese or cobalt. Binds 3 or 4 divalent metal cations. Acts specifically on U8 snoRNA with
magnesium as cofactor. Has broad substrate specificity with bound manganese or cobalt (in vitro)
Subunit: Homodimer
Subcellular location: Nucleus. Nucleus, nucleoplasm (By similarity). Nucleus, nucleolus. Cytoplasm. Note=Localized
predominantly in the cytoplasm. Localized in nucleolus, and in a minor proportion in distinct foci in the
nucleoplasm (By similarity)
Sequence caution: Sequence=BAB71024.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
3 PDB 3D structures from and Proteopedia for NUDT16:
2XSQ (3D)        3COU (3D)        3MGM (3D)    
Secondary accessions: B4E3B4 E9PED4 F5GYJ1 Q96N82
Alternative splicing: 4 isoforms:  Q96DE0-1   Q96DE0-2   Q96DE0-3   Q96DE0-4   (No experimental confirmation available. Ref.2 (BP199028) sequence is in conflict in position: 128:A->Missing)

Explore the universe of human proteins at neXtProt for NUDT16: NX_Q96DE0

Explore proteomics data for NUDT16 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96DE0

  • 2 DME Specific Peptides for NUDT16 (Q96DE0)
     HACHALL  MRFDGRLGFPGGFVD 

    NUDT16 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NUDT16 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001165376.1  NP_001165377.1  NP_689608.2  

    ENSEMBL proteins: 
     ENSP00000429274   ENSP00000422375   ENSP00000352911   ENSP00000440230  
    Reactome Protein details: Q96DE0
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    Cloud-Clone Corp. Proteins for NUDT16 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--

    NUDT16 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    NUDT: Nudix motif containing

    2 InterPro protein domains:
     IPR015797 NUDIX_hydrolase_dom-like
     IPR000086 NUDIX_hydrolase_dom

    Graphical View of Domain Structure for InterPro Entry Q96DE0

    ProtoNet protein and cluster: Q96DE0

    1 Blocks protein domain: IPB000086 NUDIX hydrolase

    UniProtKB/Swiss-Prot: NUD16_HUMAN, Q96DE0
    Similarity: Belongs to the Nudix hydrolase family. NUDT16 subfamily
    Similarity: Contains 1 nudix hydrolase domain


    NUDT16 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NUD16_HUMAN, Q96DE0
    Function: RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs
    in a metal-dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S
    and 28S rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a
    5'monophosphate on the RNA. Catalyzes also the cleavage of the cap structure on mRNAs. Does not hydrolyze cap
    analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG). Also hydrolysis m7G- and m227G
    U3-capped RNAs but with less efficiencies. Has broad substrate specificity with manganese or cobalt as cofactor
    and can act on various RNA species. Binds to the U8 snoRNA; metal is not required for RNA-binding. May play a
    role in the regulation of snoRNAs and mRNAs degradation. Acts also as a phosphatase; hydrolyzes the non-canonical
    purine nucleotides inosine diphosphate (IDP) and deoxyinosine diphosphate (dITP) as well as guanosine diphosphate
    (GDP), deoxyguanosine diphosphate (dGDP), xanthine diphosphate (XDP), inosine triphosphate (ITP) and deoxyinosine
    triphosphate (ITP) to their respective monophosphate derivatives and does not distinguish between the deoxy- and
    ribose forms. The order of activity with different substrates is IDP > dIDP >> GDP = dGDP > XDP = ITP = dITP.
    Binds strongly to GTP, ITP and XTP. Participates in the hydrolysis of dIDP/IDP and probably excludes
    non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and
    avoiding chromosomal lesions
    Catalytic activity: M(7)G5'ppp5'-mRNA + H(2)O = m(7)GDP + 5'-phospho-mRNA
    Catalytic activity: IDP + H(2)O = IMP + phosphate
    Biophysicochemical properties: Kinetic parameters: KM=0.062 uM for IDP (at 37 degrees Celsius); KM=0.088 uM for
    dIDP (at 37 degrees Celsius); KM=0.330 uM for GDP (at 37 degrees Celsius); KM=0.319 mM for dGDP (at 37 degrees
    Celsius); KM=15.7 mM for XDP (at 37 degrees Celsius); KM=22.1 mM for ITP (at 37 degrees Celsius); KM=24.1 mM for
    dITP (at 37 degrees Celsius); Note=kcat is 0.931 sec(-1) with IDP. kcat is 0.966 sec(-1) with dIDP. kcat is 0.518
    sec(-1) with GDP. kcat is 0.492 sec(-1) with dGDP. kcat is 2.6 sec(-1) with XDP. kcat is 3.06 sec(-1) with ITP.
    kcat is 3.2 sec(-1) with dITP. The catalytic efficiency for IDP is at least 1.3-fold higher than for dIDP,
    9.6-fold higher than for GDP and dGDP, 100-fold higher than for XDP, ITP and dITP; pH dependence: Gradually
    increased from pH 6.5 to 8.5 in its IDP hydrolyzing activity; Temperature dependence: Exhibited a
    temperature-dependent increase in its IDP hydrolyzing activity up to 60 degrees Celsius;

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.1.621 EC 3.6.1.-1

         Gene Ontology (GO): 5/16 molecular function terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA17567574
    GO:0003729mRNA binding IDA--
    GO:0005525GTP binding IDA--
    GO:0008235metalloexopeptidase activity IDA--
    GO:0016787hydrolase activity ----
         
    NUDT16 for ontologies           About GeneDecksing


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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NUDT16 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    RNA degradation0.49
    2Purine metabolism
    Metabolism of nucleotides0.42
    3Metabolism
    Metabolism0.40
    4Purine metabolism
    Purine metabolism0.38
    5Phosphate bond hydrolysis by NUDT proteins
    Phosphate bond hydrolysis by NUDT proteins

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3        Reactome Pathways for NUDT16
        Metabolism of nucleotides
    Metabolism
    Phosphate bond hydrolysis by NUDT proteins


    2         Kegg Pathways  (Kegg details for NUDT16):
        Purine metabolism
    RNA degradation


    NUDT16 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NUDT16

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006382adenosine to inosine editing IMP--
    GO:0006402mRNA catabolic process IDA--
    GO:0008284positive regulation of cell proliferation IMP--
    GO:0016077snoRNA catabolic process IDA15053875
    GO:0034656nucleobase-containing small molecule catabolic process TAS--

    NUDT16 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NUDT16 (NUD16)

    3 HMDB Compounds for NUDT16    About this table
    CompoundSynonyms CAS #PubMed Ids
    CobaltCo (see all 6)7440-48-4--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--

    Search CenterWatch for drugs/clinical trials and news about NUDT16 / NUD16

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NUDT16 gene (3 alternative transcripts): 
    NM_001171905.1  NM_001171906.1  NM_152395.2  

    Unigene Cluster for NUDT16:

    Nudix (nucleoside diphosphate linked moiety X)-type motif 16
    Hs.282050  [show with all ESTs]
    Unigene Representative Sequence: NR_033268
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000521288(uc011bln.2) ENST00000502852(uc021xec.1) ENST00000359850(uc003eog.2)
    ENST00000537561(uc021xeb.1)
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    Additional mRNA sequence: 

    AK055827.1 AK091353.1 AK093567.1 AK295852.1 AK304650.1 BC009546.1 BC031215.1 NR_033268.1 

    8 DOTS entries:

    DT.95120554  DT.454593  DT.99975272  DT.97792057  DT.100836014  DT.91984243  DT.92423708  DT.95297550 

    24/164 AceView cDNA sequences (see all 164):

    AW593922 AA348380 AI871084 AI559328 BU145600 CA426855 BQ428332 BQ706802 
    BX102635 CK818835 CA308550 AI458935 BF196088 BE252467 AI801130 CB051405 
    AK091353 CK818834 BF436847 AI085945 BX645389 CD722521 AA342069 CN485263 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NUDT16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NUDT16 Expression
    About this image


    See NUDT16 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NUDT16

    SOURCE GeneReport for Unigene cluster: Hs.282050

    UniProtKB/Swiss-Prot: NUD16_HUMAN, Q96DE0
    Tissue specificity: Expressed strongly in lung, kidney, adrenal gland, testis, heart and brain

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NUDT16 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nudt161 , 5 nudix (nucleoside diphosphate linked moiety X)-type more1, 5 81.08(n)1
    80.73(a)1
      9 (56.61 cM)5
    756861  NM_029385.21  NP_083661.21 
     1051293385 
    lizard
    (Anolis carolinensis)
    Reptilia NUDT166
    Uncharacterized protein
    45(a)
    1 → many
    2(88312928-88318594)
    zebrafish
    (Danio rerio)
    Actinopterygii CK361916.12   -- 72.48(n)    CK361916.1 


    ENSEMBL Gene Tree for NUDT16 (if available)
    TreeFam Gene Tree for NUDT16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NUDT16 gene
    NUDT16L12  
    1 SIMAP similar gene for NUDT16 using alignment to 1 protein entry:     NUD16_HUMAN:
    NUDT16L1

    NUDT16 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NUDT16
    PGOHUM00000250305


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/106 SNPs in NUDT16 are shown (see all 106)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs788805521,2
    --131102329(+) CATATA/GTTTTG 3 -- ut31 nc-transcript-variant0--------
    rs1142417561,2
    C,F--131102581(+) TGAAGC/TAAGGG 3 -- ut31 nc-transcript-variant1Minor allele frequency- T:0.02NA 120
    rs1123502601,2
    C,F--131102599(+) TTCCCA/TCACTC 3 -- ut31 nc-transcript-variant2Minor allele frequency- T:0.04CSA WA 120
    rs168365731,2
    C,F,H--131102776(+) TTTCTT/GCTGAA 3 -- ut31 nc-transcript-variantese3 trp312Minor allele frequency- G:0.04NA NS EA 1450
    rs1866724661,2
    --131103036(+) ACAAGA/GCCCTG 3 -- ut31 nc-transcript-variant0--------
    rs28741,2
    C,F,H--131103084(-) TTAACG/ATGCCT 3 -- ut31 nc-transcript-variantese316Minor allele frequency- A:0.09MN NA NS EA WA CSA 1541
    rs1402625281,2
    C--131103103(+) GAAAGC/TGGACT 3 -- ut31 nc-transcript-variant0--------
    rs1910341561,2
    --131103254(+) TGGAAA/CGTTGG 3 -- ut31 nc-transcript-variant0--------
    rs1833351221,2
    --131103586(+) TCTTCC/TTTGTG 3 -- ut31 nc-transcript-variant0--------
    rs1453548631,2
    C--131103764(+) GGTGTC/GTGTGT 3 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for NUDT16 (131100515 - 131107674 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NUDT16:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv829724CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for NUDT16:    About MalaCards
    intrahepatic cholangiocarcinoma    cholangiocarcinoma


    NUDT16 for disorders           About GeneDecksing


    Export disorders for NUDT16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NUDT16 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with NUDT16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. hNUDT16: a universal decapping enzyme for small nucle olar RNA and cytoplasmic mRNA. (PubMed id 21337011)1, 2 Lu G....Yan J. (2011)
    2. NUDT16 is a (deoxy)inosine diphosphatase, and its def iciency induces accumulation of single-strand breaks in nuclear DNA and growth arrest. (PubMed id 20385596)1, 2 Iyama T....Nakabeppu Y. (2010)
    3. Multiple mRNA decapping enzymes in mammalian cells. (PubMed id 21070968)1, 2 Song M.G....Kiledjian M. (2010)
    4. Crystallization and crystallographic analysis of human NUDT16. (PubMed id 18607096)1, 2 Zhang J....Yan J. (2008)
    5. Evolutionary conservation supports ancient origin for Nudt16, a nuclear-localized, RNA-binding, RNA-decapping enzyme. (PubMed id 18820299)1, 2 Taylor M.J. and Peculis B.A. (2008)
    6. Metal determines efficiency and substrate specificity of the nuclear NUDIX decapping proteins X29 and H29K (Nudt16). (PubMed id 17567574)1, 2 Peculis B.A.... Cleland M. (2007)
    7. Xenopus U8 snoRNA binding protein is a conserved nuclear decapping enzyme. (PubMed id 15053875)1, 2 Ghosh T.... Peculis B.A. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 131870 HGNC: 26442 AceView: FLJ31265 Ensembl:ENSG00000198585 euGenes: HUgn131870
    ECgene: NUDT16 Kegg: 131870 H-InvDB: NUDT16

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NUDT16 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NUDT16 gene:
    Search GeneIP for patents involving NUDT16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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