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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NUDT16 Gene

protein-coding   GIFtS: 47
GCID: GC03P131100

nudix (nucleoside diphosphate linked moiety X)-type motif...
 Explore 2 diseases affiliated with
NUDT16 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NUDT16    

Aliases
for NUDT16 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 161 2     EC 3.6.1.-3
Nucleoside Diphosphate-Linked Moiety X Motif 162 3     EC 3.6.1.623
Nudix Motif 162 3     IDPase3
M7GpppN-MRNA Hydrolase2 3     IDP Phosphatase3
U8 SnoRNA-Binding Protein H29K2 3     Inosine Diphosphate Phosphatase3
FLJ312651     EC 3.6.18
U8 SnoRNA-Decapping Enzyme2     

External Ids:    HGNC: 264421   Entrez Gene: 1318702   Ensembl: ENSG000001985857   UniProtKB: Q96DE03   
ORGUL members:         
NONCODE:n342542 n409150    

Export aliases for NUDT16 gene to outside databases

Previous GC identifers: GC03P132584 GC03P128485


Summaries
for NUDT16 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: NUD16_HUMAN, Q96DE0
Function: RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a
metal-dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S
rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5'monophosphate on the
RNA. Catalyzes also the cleavage of the cap structure on mRNAs. Does not hydrolyze cap analog structures like
7-methylguanosine nucleoside triphosphate (m7GpppG). Also hydrolysis m7G- and m227G U3-capped RNAs but with less
efficiencies. Has broad substrate specificity with manganese or cobalt as cofactor and can act on various RNA species.
Binds to the U8 snoRNA; metal is not required for RNA-binding. May play a role in the regulation of snoRNAs and mRNAs
degradation. Acts also as a phosphatase; hydrolyzes the non-canonical purine nucleotides inosine diphosphate (IDP) and
deoxyinosine diphosphate (dITP) as well as guanosine diphosphate (GDP), deoxyguanosine diphosphate (dGDP), xanthine
diphosphate (XDP), inosine triphosphate (ITP) and deoxyinosine triphosphate (ITP) to their respective monophosphate
derivatives and does not distinguish between the deoxy- and ribose forms. The order of activity with different
substrates is IDP > dIDP >> GDP = dGDP > XDP = ITP = dITP. Binds strongly to GTP, ITP and XTP. Participates in the
hydrolysis of dIDP/IDP and probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing
their incorporation into RNA and DNA and avoiding chromosomal lesions




Genomic Views
for NUDT16 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NUDT16 gene promoter:
         MAZR   p53   AP-4   GATA-1   RORalpha2   GATA-2   CREB   STAT3   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NUDT16 promoter sequence
   Search SABiosciences Chromatin IP Primers for NUDT16

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUDT16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22.1   Ensembl cytogenetic band:  3q22.1   HGNC cytogenetic band: 3q21.3

NUDT16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUDT16 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P131100:  view genomic region     (about GC identifiers)

Start:
 131,100,515 bp from pter      End:
 131,107,674 bp from pter
Size:
 7,160 bases      Orientation:
 plus strand
ORGUL member locations:
Legend (see complete legend)

  • n409150
  • n342542
131100624 131104149 131107674 chr3

Proteins
for NUDT16 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NUD16_HUMAN, Q96DE0 (See protein sequence)
Recommended Name: U8 snoRNA-decapping enzyme  
Size: 195 amino acids; 21273 Da
Cofactor: Magnesium, manganese or cobalt. Binds 3 or 4 divalent metal cations. Acts specifically on U8 snoRNA with
magnesium as cofactor. Has broad substrate specificity with bound manganese or cobalt (in vitro)
Subunit: Homodimer
Subcellular location: Nucleus. Nucleus, nucleoplasm (By similarity). Nucleus, nucleolus. Cytoplasm. Note=Localized
predominantly in the cytoplasm. Localized in nucleolus, and in a minor proportion in distinct foci in the nucleoplasm
(By similarity)
Sequence caution: Sequence=BAB71024.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
3 PDB 3D structures from and Proteopedia for NUDT16:
2XSQ (3D)        3COU (3D)        3MGM (3D)    
Secondary accessions: B4E3B4 E9PED4 F5GYJ1 Q96N82
Alternative splicing: 3 isoforms:  Q96DE0-1   Q96DE0-2   Q96DE0-3   (No experimental confirmation available. Ref.2 (BP199028) sequence is in conflict in position: 128:A->Missing)

Explore the universe of human proteins at neXtProt for NUDT16: NX_Q96DE0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96DE0

    • 2 DME Specific Peptides for NUDT16 (Q96DE0)
     HACHALL  MRFDGRLGFPGGFVD 

    NUDT16 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001165376.1  NP_001165377.1  NP_689608.2  

    ENSEMBL proteins: 
     ENSP00000429274   ENSP00000422375   ENSP00000352911   ENSP00000440230  
    Reactome Protein details: Q96DE0
    Human Recombinant Protein Products: 
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    Novus Biologicals NUDT16 Proteins
    Novus Biologicals NUDT16 Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for NUDT16
    Uscn Proteins for NUDT16

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm IEA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--


    NUDT16 for ontologies           About GeneDecksing



    NUDT16 Antibody Products: 
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    Uscn Antibodies for NUDT16
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    Uscn ELISAs and CLIAs for NUDT16

    Protein Domains /
    Families
    for NUDT16 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NUDT16 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR015797 NUDIX_hydrolase_dom-like
     IPR000086 NUDIX_hydrolase_dom

    Graphical View of Domain Structure for InterPro Entry Q96DE0

    ProtoNet protein and cluster: Q96DE0

    1 Blocks protein family: IPB000086 NUDIX hydrolase

    UniProtKB/Swiss-Prot: NUD16_HUMAN, Q96DE0
    Similarity: Belongs to the Nudix hydrolase family. NUDT16 subfamily
    Similarity: Contains 1 nudix hydrolase domain


    Function
    for NUDT16 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NUD16_HUMAN, Q96DE0
    Function: RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a
    metal-dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S
    rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5'monophosphate on the
    RNA. Catalyzes also the cleavage of the cap structure on mRNAs. Does not hydrolyze cap analog structures like
    7-methylguanosine nucleoside triphosphate (m7GpppG). Also hydrolysis m7G- and m227G U3-capped RNAs but with less
    efficiencies. Has broad substrate specificity with manganese or cobalt as cofactor and can act on various RNA species.
    Binds to the U8 snoRNA; metal is not required for RNA-binding. May play a role in the regulation of snoRNAs and mRNAs
    degradation. Acts also as a phosphatase; hydrolyzes the non-canonical purine nucleotides inosine diphosphate (IDP) and
    deoxyinosine diphosphate (dITP) as well as guanosine diphosphate (GDP), deoxyguanosine diphosphate (dGDP), xanthine
    diphosphate (XDP), inosine triphosphate (ITP) and deoxyinosine triphosphate (ITP) to their respective monophosphate
    derivatives and does not distinguish between the deoxy- and ribose forms. The order of activity with different
    substrates is IDP > dIDP >> GDP = dGDP > XDP = ITP = dITP. Binds strongly to GTP, ITP and XTP. Participates in the
    hydrolysis of dIDP/IDP and probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing
    their incorporation into RNA and DNA and avoiding chromosomal lesions
    Catalytic activity: M(7)G5'ppp5'-mRNA + H(2)O = m(7)GDP + 5'-phospho-mRNA
    Catalytic activity: IDP + H(2)O = IMP + phosphate
    Biophysicochemical properties: Kinetic parameters: KM=0.062 uM for IDP (at 37 degrees Celsius); KM=0.088 uM for dIDP
    (at 37 degrees Celsius); KM=0.330 uM for GDP (at 37 degrees Celsius); KM=0.319 mM for dGDP (at 37 degrees Celsius);
    KM=15.7 mM for XDP (at 37 degrees Celsius); KM=22.1 mM for ITP (at 37 degrees Celsius); KM=24.1 mM for dITP (at 37
    degrees Celsius); Note=kcat is 0.931 sec(-1) with IDP. kcat is 0.966 sec(-1) with dIDP. kcat is 0.518 sec(-1) with
    GDP. kcat is 0.492 sec(-1) with dGDP. kcat is 2.6 sec(-1) with XDP. kcat is 3.06 sec(-1) with ITP. kcat is 3.2 sec(-1)
    with dITP. The catalytic efficiency for IDP is at least 1.3-fold higher than for dIDP, 9.6-fold higher than for GDP
    and dGDP, 100-fold higher than for XDP, ITP and dITP; pH dependence: Gradually increased from pH 6.5 to 8.5 in its IDP
    hydrolyzing activity; Temperature dependence: Exhibited a temperature-dependent increase in its IDP hydrolyzing
    activity up to 60 degrees Celsius;

    Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.1.621 EC 3.6.1.-1

    miRNA
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    hsa-miR-767-3p hsa-miR-186* hsa-miR-1207-5p hsa-miR-455-3p
    SwitchGear 3'UTR luciferase reporter plasmid: NUDT16 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Browse Sino Biological Human cDNA Clones
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    Cell Line
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    Search LifeMap BioReagents cell lines for NUDT16

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT16

    Gene Ontology (GO): 5/16 molecular function terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA17567574
    GO:0003723RNA binding ----
    GO:0003729mRNA binding IDA--
    GO:0005525GTP binding IDA--
    GO:0008235metalloexopeptidase activity IDA--


    NUDT16 for ontologies           About GeneDecksing



    Pathways & Interactions
    for NUDT16 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Phosphate bond hydrolysis by NUDT proteins
    		Phosphate bond hydrolysis by NUDT proteins1.00
    2Metabolism
    		Metabolism1.00
    3Purine metabolism
    		Metabolism of nucleotides0.42

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for NUDT16
        Metabolism of nucleotides
    Metabolism
    Phosphate bond hydrolysis by NUDT proteins



    NUDT16 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NUDT16

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006382adenosine to inosine editing IMP--
    GO:0006402mRNA catabolic process IDA--
    GO:0008284positive regulation of cell proliferation IMP--
    GO:0016077snoRNA catabolic process IDA--
    GO:0035863dITP catabolic process ISS--


    NUDT16 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NUDT16 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for NUDT16

    3 HMDB Compounds for NUDT16    About this table
    CompoundSynonyms CAS #PubMed Ids
    CobaltCo (see all 6)7440-48-4--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--
    Search CenterWatch for drugs/clinical trials and news about NUDT16 / NUD16 

    Transcripts
    for NUDT16 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NUDT16 gene (3 alternative transcripts): 
    NM_001171905.1  NM_001171906.1  NM_152395.2  

    Unigene Cluster for NUDT16:

    Nudix (nucleoside diphosphate linked moiety X)-type motif 16
    Hs.282050  [show with all ESTs]
    Unigene Representative Sequence: NR_033268
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000521288(uc011bln.2) ENST00000502852(uc021xec.1) ENST00000359850(uc003eog.2)
    ENST00000537561(uc021xeb.1)

    miRNA
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    4 QIAGEN miScript miRNA Assays for microRNAs that regulate NUDT16:
    hsa-miR-767-3p hsa-miR-186* hsa-miR-1207-5p hsa-miR-455-3p
    SwitchGear 3'UTR luciferase reporter plasmid: NUDT16 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NUDT16 (see all 7)
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK055827.1 AK091353.1 AK093567.1 AK295852.1 AK304650.1 BC009546.1 BC031215.1 NR_033268.1 

    8 DOTS entries:

    DT.95120554  DT.454593  DT.99975272  DT.97792057  DT.100836014  DT.91984243  DT.92423708  DT.95297550 

    24/164 AceView cDNA sequences (see all 164):

    CR604284 BX102635 BX645389 AW305225 BG056433 BM685203 BC009546 BM932208 
    BU634340 CB051405 AI085945 AI985307 AI871084 CA434146 BE252467 CB121755 
    BQ428332 AW003338 BU145600 CK818835 CA426855 AI801130 CN485263 AW612580 

    GeneLoc Exon Structure


    Expression
    for NUDT16 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NUDT16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See NUDT16 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NUDT16

    SOURCE GeneReport for Unigene cluster: Hs.282050

    UniProtKB/Swiss-Prot: NUD16_HUMAN, Q96DE0
    Tissue specificity: Expressed strongly in lung, kidney, adrenal gland, testis, heart and brain

        SABiosciences Custom PCR Arrays for NUDT16
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT16

    Orthologs
    for NUDT16 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for NUDT16 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Nudt161 , 5 nudix (nucleoside diphosphate linked moiety X)-type more1, 5 81.08(n)1
    80.73(a)1    		   9 (56.61 cM)5
    756861  NM_029385.21  NP_083661.21 
     1051293385 
    lizard
    (Anolis carolinensis)    		 Reptilia NUDT166
    		 --
    		 45(a)
    		 1 → many
    		 2(88312928-88318594)
    zebrafish
    (Danio rerio)    		 Actinopterygii CK361916.12   -- 72.48(n)    CK361916.1 


    ENSEMBL Gene Tree for NUDT16 (if available)
    TreeFam Gene Tree for NUDT16 (if available) 

    Paralogs
    for NUDT16 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NUDT16 gene
    NUDT16L12  
    1 SIMAP similar gene for NUDT16 using alignment to 1 protein entry:     NUD16_HUMAN:
    NUDT16L1

    NUDT16 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NUDT16
    PGOHUM00000250305


    Genomic Variants
    for NUDT16 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/164 NCBI SNPs in NUDT16 are shown (see all 164)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs168365381,2
    		C,F,--131098553(+) CCTATC/GTAGGA 2 -- us2k1 int14Minor allele frequency- G:0.03NA EA 262
    rs98335251,2
    		H--131098560(+) AGGAGA/TAAAAC 2 -- int1 us2k1 trp34Minor allele frequency- T:0.00NS EA 418
    rs1866130641,2
    		--131098572(+) AAGTCA/GCCTTT 2 -- us2k1 int10--------
    rs738708761,2
    		C,F,--131098605(+) GGCCCC/TGGTTC 2 -- int1 us2k16Minor allele frequency- T:0.27WA CSA NA EA 364
    rs738708771,2
    		C,F,--131098653(+) AAACCG/ACATAT 5 -- us2k1 int16Minor allele frequency- A:0.27WA CSA NA EA 364
    rs1911469731,2
    		--131098694(+) AACTGC/GTCTGT 5 -- us2k1 int10--------
    rs1849719211,2
    		--131098707(+) TAGGAA/CAAAGT 5 -- us2k1 int10--------
    rs577674371,2
    		C,F,--131098792(+) CTGGAA/GCTCTA 5 -- int1 us2k16Minor allele frequency- G:0.24WA CSA NA EA 364
    rs577777251,2
    		C,F,--131098806(+) GGCCAG/ATGACA 5 -- us2k1 int16Minor allele frequency- A:0.26WA CSA NA EA 364
    rs1154198691,2
    		F,--131098819(+) TGTATC/TACACC 5 -- us2k1 int11Minor allele frequency- T:0.02NA 120

    HapMap Linkage Disequilibrium report for NUDT16 (131100515 - 131107674 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for NUDT16
         1 CNV: 4353

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    Disorders / Diseases
    for NUDT16 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NUDT16 for disorders           About GeneDecksing

    2 diseases for NUDT16:    About MalaCards
    intrahepatic cholangiocarcinoma    cholangiocarcinoma


    Export disorders for NUDT16 gene to outside databases

    Publications
    for NUDT16 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NUDT16 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with NUDT16)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. hNUDT16: a universal decapping enzyme for small nucle olar RNA and cytoplasmic mRNA. (PubMed id 21337011)1, 2 Lu G....Yan J. (2011)
    2. NUDT16 is a (deoxy)inosine diphosphatase, and its def iciency induces accumulation of single-strand breaks in nuclear DNA and growth arrest. (PubMed id 20385596)1, 2 Iyama T....Nakabeppu Y. (2010)
    3. Multiple mRNA decapping enzymes in mammalian cells. (PubMed id 21070968)1, 2 Song M.G....Kiledjian M. (2010)
    4. Crystallization and crystallographic analysis of human NUDT16. (PubMed id 18607096)1, 2 Zhang J....Yan J. (2008)
    5. Evolutionary conservation supports ancient origin for Nudt16, a nuclear-localized, RNA-binding, RNA-decapping enzyme. (PubMed id 18820299)1, 2 Taylor M.J. and Peculis B.A. (2008)
    6. Metal determines efficiency and substrate specificity of the nuclear NUDIX decapping proteins X29 and H29K (Nudt16). (PubMed id 17567574)1, 2 Peculis B.A.... Cleland M. (2007)
    7. Xenopus U8 snoRNA binding protein is a conserved nuclear decapping enzyme. (PubMed id 15053875)1, 2 Ghosh T.... Peculis B.A. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)

    External Searches for NUDT16 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    Genome Databases showing NUDT16 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 131870 HGNC: 26442 AceView: FLJ31265 Ensembl:ENSG00000198585 euGenes: HUgn131870
    ECgene: NUDT16 H-InvDB: NUDT16

    Other Databases showing NUDT16 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NUDT16 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NUDT16 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NUDT16 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NUDT16 gene:
    Search GeneIP for patents involving NUDT16

    GeneCards and IP:
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