Aliases for NUDT15 Gene
- Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 15 2 3
- 8-Oxo-DGTPase NUDT15 3 4
- MutT Homolog 2 3 4
- MTH2 3 4
- Probable 7,8-Dihydro-8-Oxoguanine Triphosphatase NUDT15 3
- Nucleoside Diphosphate-Linked Moiety X Motif 15 4
- 7,8-Dihydro-8-Oxoguanine-Triphosphatase NUDT15 4
- Nudix Motif 15 4
- EC 126.96.36.199 4
External Ids for NUDT15 Gene
Previous GeneCards Identifiers for NUDT15 Gene
GeneCards Summary for NUDT15 Gene
NUDT15 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 15) is a Protein Coding gene. Diseases associated with NUDT15 include azathioprine or 6-mercatopurine toxicity or dose selection. Among its related pathways are Metabolism and Purine metabolism. GO annotations related to this gene include hydrolase activity and 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity.
UniProtKB/Swiss-Prot for NUDT15 Gene
Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear (By similarity). May have a role in DNA synthesis and cell cycle progression through the interaction with PCNA.