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NUDT15 Gene

protein-coding   GIFtS: 48
GCID: GC13P048611

Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif...

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 151 2     MTH22 3
MutT Homolog 22 3     A730068G11Rik2
Nucleoside Diphosphate-Linked Moiety X Motif 152 3     Nudix-Type Motif 152
Nudix Motif 152 3     Probable 7,8-Dihydro-8-Oxoguanine Triphosphatase NUDT152
7,8-Dihydro-8-Oxoguanine-Triphosphatase NUDT152 3     Probable 8-Oxo-DGTP Diphosphatase NUDT152
8-Oxo-DGTPase NUDT152 3     EC 3.6.1.553

External Ids:    HGNC: 230631   Entrez Gene: 552702   Ensembl: ENSG000001361597   UniProtKB: Q9NV353   

Export aliases for NUDT15 gene to outside databases

Previous GC identifers: GC13P046409 GC13P047509 GC13P029404


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NUDT15 Gene:
NUDT15 (nudix (nucleoside diphosphate linked moiety X)-type motif 15) is a protein-coding gene. Diseases associated with NUDT15 include myelitis. GO annotations related to this gene include 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity and 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity.

UniProtKB/Swiss-Prot: NUD15_HUMAN, Q9NV35
Function: Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro,
suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the
nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G
transversions. Its substrate specificity in vivo however remains unclear (By similarity). May have a role in DNA
synthesis and cell cycle progression through the interaction with PCNA




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NC_018924.2  NT_024524.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the NUDT15 gene promoter:
         AP-1   p300   NCX/Ncx   HTF   STAT5A   E4BP4   LCR-F1   S8   c-Myb   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNUDT15 promoter sequence
   Search Chromatin IP Primers for NUDT15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NUDT15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.2   Ensembl cytogenetic band:  13q14.2   HGNC cytogenetic band: 13q14.12

NUDT15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUDT15 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P048611:  view genomic region     (about GC identifiers)

Start:
48,611,703 bp from pter      End:
48,621,358 bp from pter
Size:
9,656 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NUD15_HUMAN, Q9NV35 (See protein sequence)
Recommended Name: Probable 8-oxo-dGTP diphosphatase NUDT15  
Size: 164 amino acids; 18609 Da
Cofactor: Magnesium or manganese. Magnesium may be the real cofactor in vivo (By similarity)
Subunit: Interacts with PCNA; interaction is disrupted in response to UV irradiation
Secondary accessions: A2RUR6 Q32Q27 Q6P2C9

Explore the universe of human proteins at neXtProt for NUDT15: NX_Q9NV35

Explore proteomics data for NUDT15 at MOPED


See NUDT15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_060753.1  
ENSEMBL proteins: 
 ENSP00000258662  
Reactome Protein details: Q9NV35

NUDT15 Human Recombinant Protein Products:

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NUDT15 Antibody Products:

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NUDT15 Assay Products:

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Cloud-Clone Corp. CLIAs for NUDT15


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
NUDT: Nudix motif containing

2 InterPro protein domains:
 IPR015797 NUDIX_hydrolase_dom-like
 IPR000086 NUDIX_hydrolase_dom

Graphical View of Domain Structure for InterPro Entry Q9NV35

ProtoNet protein and cluster: Q9NV35

1 Blocks protein domain: IPB000086 NUDIX hydrolase

UniProtKB/Swiss-Prot: NUD15_HUMAN, Q9NV35
Similarity: Belongs to the Nudix hydrolase family
Similarity: Contains 1 nudix hydrolase domain


NUDT15 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: NUD15_HUMAN, Q9NV35
Function: Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro,
suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the
nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G
transversions. Its substrate specificity in vivo however remains unclear (By similarity). May have a role in DNA
synthesis and cell cycle progression through the interaction with PCNA
Catalytic activity: 8-oxo-dGTP + H(2)O = 8-oxo-dGMP + diphosphate

     Enzyme Number (IUBMB): EC 3.6.1.551

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:00084138-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity IDA--
GO:0016787hydrolase activity ----
GO:00355398-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity IDA--
GO:0046872metal ion binding IEA--
     
NUDT15 for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NUDT15
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NUDT15

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NUDT15
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NUDT15

miRNA
Products:
    
miRTarBase miRNAs that target NUDT15:
hsa-mir-215-5p (MIRT024551), hsa-let-7e-5p (MIRT051689), hsa-mir-192-5p (MIRT026659)

Block miRNA regulation of human, mouse, rat NUDT15 using miScript Target Protectors
4 qRT-PCR Assays for microRNAs that regulate NUDT15:
hsa-miR-338-5p hsa-miR-3065-5p hsa-miR-488 hsa-miR-138-2*
SwitchGear 3'UTR luciferase reporter plasmidNUDT15 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for NUDT15
Predesigned siRNA for gene silencing in human, mouse, rat NUDT15

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for NUDT15

Clone
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OriGene clones in human, mouse for NUDT15 (see all 6)
OriGene ORF clones in mouse, rat for NUDT15
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: NUDT15 (NM_018283)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUDT15
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUDT15

Cell Line
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Browse ESI BIO Cell Lines and PureStem Progenitors for NUDT15 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT15


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol4
mitochondrion2
nucleus1
peroxisome1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005829cytosol TAS--

NUDT15 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for NUDT15 About    
See pathways by source

SuperPathContained pathways About
1Purine metabolism (REACTOME)
Metabolism of nucleotides0.42
Phosphate bond hydrolysis by NUDT proteins0.00
2Metabolism
Metabolism0.38

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for NUDT15
    Phosphate bond hydrolysis by NUDT proteins



NUDT15 for pathways           About GeneDecksing

    Pathway & Disease-focused RT2 Profiler PCR Arrays including NUDT15: 
          Nitric Oxide Signaling Pathway in human mouse rat
          Molecular Toxicology PathwayFinder 384HT in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for NUDT15

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for NUDT15 (ENSP000002586624) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
SRD5A3ENSP000002642284STRING: ENSP00000264228
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Gene Ontology (GO): 5 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006184GTP catabolic process IDA--
GO:0006203dGTP catabolic process IDA--
GO:0034656nucleobase-containing small molecule catabolic process TAS--
GO:0044281small molecule metabolic process TAS--
GO:0055086nucleobase-containing small molecule metabolic process TAS--

NUDT15 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for NUDT15 (NUD15)

8 HMDB Compounds for NUDT15    About this table
CompoundSynonyms CAS #PubMed Ids
8-Oxo-dGMP8OG;8-Oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate ----
8-Oxo-dGTP2'-deoxy-7,8-dihydro-8-oxo-Guanosine 5'-(tetrahydrogen triphosphate) (see all 6)139307-94-1--
ADPadenosindiphosphorsaeure (see all 8)58-64-0--
CDPCDP (see all 3)63-38-7--
Guanosine diphosphate5'-GDP (see all 10)146-91-8--
MagnesiumMagnesium (see all 2)7439-95-4--
Manganesemanganese 7439-96-5--
dTDPDeoxy-tdp (see all 5)491-97-4--



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for NUDT15 gene: 
NM_018283.1  

Unigene Cluster for NUDT15:

Nudix (nucleoside diphosphate linked moiety X)-type motif 15
Hs.144407  [show with all ESTs]
Unigene Representative Sequence: AK001818
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000258662(uc001vbv.3 uc001vbw.1)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat NUDT15 using miScript Target Protectors
4 qRT-PCR Assays for microRNAs that regulate NUDT15:
hsa-miR-338-5p hsa-miR-3065-5p hsa-miR-488 hsa-miR-138-2*
SwitchGear 3'UTR luciferase reporter plasmidNUDT15 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for NUDT15
Predesigned siRNA for gene silencing in human, mouse, rat NUDT15
Clone
Products:
     
OriGene clones in human, mouse for NUDT15 (see all 6)
OriGene ORF clones in mouse, rat for NUDT15
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: NUDT15 (NM_018283)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUDT15
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUDT15
Primer
Products:
    
OriGene qPCR primer pairs and template standards for NUDT15
OriGene qSTAR qPCR primer pairs in human, mouse for NUDT15
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NUDT15
  QuantiTect SYBR Green Assays in human, mouse, rat NUDT15
  QuantiFast Probe-based Assays in human, mouse, rat NUDT15

Additional mRNA sequence: 

AK001818.1 BC050698.1 BC064607.1 BC107875.1 BC133015.1 BC133017.1 

7 DOTS entries:

DT.426749  DT.97772552  DT.99996793  DT.100767198  DT.100019246  DT.40122269  DT.92433503 

Selected AceView cDNA sequences (see all 70):

BU622058 NM_018283 CR599539 AK001818 AL546804 BG251804 AW149964 AI350437 
AW002750 BU676361 BU190450 AU134750 BC050698 BM465681 BQ787890 AW518502 
BC064607 CF886861 AW512792 AA622208 AL546185 AA284049 AL546779 BM750668 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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NUDT15 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGTATGCAGA
NUDT15 Expression
About this image

NUDT15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

NUDT15 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.144407
    Pathway & Disease-focused RT2 Profiler PCR Arrays including NUDT15: 
          Nitric Oxide Signaling Pathway in human mouse rat
          Molecular Toxicology PathwayFinder 384HT in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for NUDT15
OriGene qSTAR qPCR primer pairs in human, mouse for NUDT15
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NUDT15
QuantiTect SYBR Green Assays in human, mouse, rat NUDT15
QuantiFast Probe-based Assays in human, mouse, rat NUDT15
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT15

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for NUDT15 gene from Selected species (see all 15)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Nudt151 , 5 nudix (nucleoside diphosphate linked moiety X)-type more1, 5 85.08(n)1
90.91(a)1
  14 (39.06 cM)5
2142541  NM_172527.21  NP_766115.11 
 735198645 
chicken
(Gallus gallus)
Aves NUDT151 nudix (nucleoside diphosphate linked moiety X)-type more 64.78(n)
67.38(a)
  418858  XM_004938701.1  XP_004938758.1 
lizard
(Anolis carolinensis)
Reptilia NUDT156
nudix (nucleoside diphosphate linked moiety X)-typ...
72(a)
1 ↔ 1
1(136977529-136982154)
African clawed frog
(Xenopus laevis)
Amphibia LOC3986402 hypothetical protein LOC398640 72.73(n)    BC054313.1 
zebrafish
(Danio rerio)
Actinopterygii nudt151 nudix (nucleoside diphosphate linked moiety X)-type more 61.87(n)
58.33(a)
  415197  NM_001002107.1  NP_001002107.1 
thale cress
(Arabidopsis thaliana)
eudicotyledons NUDX11 NUDX1 52.82(n)
47.46(a)
  843207  NM_105549.3  NP_177044.1 


ENSEMBL Gene Tree for NUDT15 (if available)
TreeFam Gene Tree for NUDT15 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for NUDT15 gene

NUDT15 for paralogs           About GeneDecksing


2 Pseudogenes.org Pseudogenes for NUDT15
PGOHUM00000237029 PGOHUM00000249354


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for NUDT15 (see all 286)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 13 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1875906281,2
--48609896(+) GCTTTC/TTAATT 1 -- us2k10--------
rs2009835521,2
--48609916(+) GATTG-/TTTTTA 1 -- us2k10--------
rs1455872331,2
C--48609921(+) GTTTT-/AAAAAA 1 -- us2k10--------
rs1920081751,2
--48609921(+) GTTTTA/TAAAAA 1 -- us2k10--------
rs770331331,2
F--48609969(+) TTTTAT/CTGATT 1 -- us2k11Minor allele frequency- C:0.03WA 118
rs2000446571,2
C--48610119(-) GGCTTG/TATACT 1 -- us2k10--------
rs1381165701,2
--48610182(+) ACAATA/TCTGGA 1 -- us2k10--------
rs1428041811,2
C--48610284(+) ATCATA/GCAGTC 1 -- us2k10--------
rs1141332261,2
C,F--48610292(+) GTCTTC/TCAATA 1 -- us2k11Minor allele frequency- T:0.03WA 118
rs1460586901,2
--48610346(+) AGTCAC/TAACAT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for NUDT15 (48611703 - 48621358 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for NUDT15:    About this table    
Variant IDTypeSubtypePubMed ID
nsv832601CNV Gain17160897

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing NUDT15
DNA2.0 Custom Variant and Variant Library Synthesis for NUDT15

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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1 disease for NUDT15:    
About MalaCards
myelitis


NUDT15 for disorders           About GeneDecksing


Export disorders for NUDT15 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for NUDT15 gene, integrated from 10 sources (see all 11):
(articles sorted by number of sources associating them with NUDT15)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Proliferating cell nuclear antigen is protected from degradation by forming a complex with MutT Homolog2. (PubMed id 19419956)1, 2, 9 Yu Y.... Zhu W.-G. (J. Biol. Chem. 2009)
  2. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  5. Mouse MTH2 protein which prevents mutations caused by 8-oxoguanine nucleotides. (PubMed id 12767940)1, 3 Cai J.P....Sekiguchi M. (Biochem. Biophys. Res. Commun. 2003)
  6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
  7. Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2. (PubMed id 22556419)2 Takagi Y.... Sekiguchi M. (J. Biol. Chem. 2012)
  8. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
  9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
  10. Suppression of mutagenesis by 8-hydroxy-2'-deoxyguanosine 5'-triphosphate (7,8-dihydro-8-oxo-2'-deoxyguanosine 5'-triphosphate) by human MTH1, MTH2, and NUDT5. (PubMed id 20144704)1 Hori M....Kamiya H. (amp 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 55270 HGNC: 23063 AceView: NUDT15 Ensembl:ENSG00000136159 euGenes: HUgn55270
ECgene: NUDT15 H-InvDB: NUDT15

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for NUDT15 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for NUDT15 gene:
Search GeneIP for patents involving NUDT15

GeneCards and IP:
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