Aliases for NUDT15 Gene
External Ids for NUDT15 Gene
Previous GeneCards Identifiers for NUDT15 Gene
GeneCards Summary for NUDT15 Gene
NUDT15 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 15) is a Protein Coding gene. Among its related pathways are Metabolism and Purine metabolism (REACTOME). GO annotations related to this gene include 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity and 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity.
UniProtKB/Swiss-Prot for NUDT15 Gene
Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear (By similarity). May have a role in DNA synthesis and cell cycle progression through the interaction with PCNA.