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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NUDT15 Gene

protein-coding   GIFtS: 48
GCID: GC13P048611

Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif...

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 151 2     A730068G11Rik2
MutT Homolog 22 3     RP11-90M2.12
Nucleoside Diphosphate-Linked Moiety X Motif 152 3     Nudix-Type Motif 152
Nudix Motif 152 3     Probable 7,8-Dihydro-8-Oxoguanine Triphosphatase NUDT152
7,8-Dihydro-8-Oxoguanine-Triphosphatase NUDT152 3     Probable 8-Oxo-DGTP Diphosphatase NUDT152
8-Oxo-DGTPase NUDT152 3     EC 3.6.1.553
MTH22 3     

External Ids:    HGNC: 230631   Entrez Gene: 552702   Ensembl: ENSG000001361597   UniProtKB: Q9NV353   

Export aliases for NUDT15 gene to outside databases

Previous GC identifers: GC13P046409 GC13P047509 GC13P029404


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NUDT15 Gene: 
NUDT15 (nudix (nucleoside diphosphate linked moiety X)-type motif 15) is a protein-coding gene. Diseases associated with NUDT15 include myelitis, and among its related super-pathways are Purine metabolism and Metabolic pathways. GO annotations related to this gene include 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity and 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity.

UniProtKB/Swiss-Prot: NUD15_HUMAN, Q9NV35
Function: Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro,
suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the
nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G
transversions. Its substrate specificity in vivo however remains unclear (By similarity). May have a role in DNA
synthesis and cell cycle progression through the interaction with PCNA




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.2  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NUDT15 gene promoter:
         AP-1   p300   NCX/Ncx   HTF   STAT5A   E4BP4   LCR-F1   S8   c-Myb   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNUDT15 promoter sequence
   Search SABiosciences Chromatin IP Primers for NUDT15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUDT15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.2   Ensembl cytogenetic band:  13q14.2   HGNC cytogenetic band: 13q14.12

NUDT15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUDT15 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P048611:  view genomic region     (about GC identifiers)

Start:
48,611,703 bp from pter      End:
48,621,358 bp from pter
Size:
9,656 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NUD15_HUMAN, Q9NV35 (See protein sequence)
Recommended Name: Probable 8-oxo-dGTP diphosphatase NUDT15  
Size: 164 amino acids; 18609 Da
Cofactor: Magnesium or manganese. Magnesium may be the real cofactor in vivo (By similarity)
Subunit: Interacts with PCNA; interaction is disrupted in response to UV irradiation
Secondary accessions: A2RUR6 Q32Q27 Q6P2C9

Explore the universe of human proteins at neXtProt for NUDT15: NX_Q9NV35

Explore proteomics data for NUDT15 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NV35

  • NUDT15 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NUDT15 Protein Expression
    REFSEQ proteins: NP_060753.1  
    ENSEMBL proteins: 
     ENSP00000258662  
    Reactome Protein details: Q9NV35
    Human Recombinant Protein Products for NUDT15: 
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    Novus Biologicals NUDT15 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NUDT15 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    NUDT15 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    NUDT: Nudix motif containing

    2 InterPro protein domains:
     IPR015797 NUDIX_hydrolase_dom-like
     IPR000086 NUDIX_hydrolase_dom

    Graphical View of Domain Structure for InterPro Entry Q9NV35

    ProtoNet protein and cluster: Q9NV35

    1 Blocks protein domain: IPB000086 NUDIX hydrolase

    UniProtKB/Swiss-Prot: NUD15_HUMAN, Q9NV35
    Similarity: Belongs to the Nudix hydrolase family
    Similarity: Contains 1 nudix hydrolase domain


    NUDT15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NUD15_HUMAN, Q9NV35
    Function: Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro,
    suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the
    nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G
    transversions. Its substrate specificity in vivo however remains unclear (By similarity). May have a role in DNA
    synthesis and cell cycle progression through the interaction with PCNA
    Catalytic activity: 8-oxo-dGTP + H(2)O = 8-oxo-dGMP + diphosphate

         Enzyme Number (IUBMB): EC 3.6.1.551

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00084138-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity IDA--
    GO:0016787hydrolase activity ----
    GO:00355398-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity IDA--
    GO:0046872metal ion binding IEA--
         
    NUDT15 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NUDT15 
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    miRNA
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    4 QIAGEN miScript miRNA Assays for microRNAs that regulate NUDT15:
    hsa-miR-338-5p hsa-miR-3065-5p hsa-miR-488 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidNUDT15 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NUDT15 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Purine metabolism
    Metabolism of nucleotides0.42
    2Metabolism
    Metabolism0.40
    3Phosphate bond hydrolysis by NUDT proteins
    Phosphate bond hydrolysis by NUDT proteins

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3        Reactome Pathways for NUDT15
        Metabolism of nucleotides
    Metabolism
    Phosphate bond hydrolysis by NUDT proteins



    NUDT15 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NUDT15

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for NUDT15 (ENSP000002586624) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SRD5A3ENSP000002642284STRING: ENSP00000264228
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process IDA--
    GO:0006203dGTP catabolic process IDA--
    GO:0034656nucleobase-containing small molecule catabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0055086nucleobase-containing small molecule metabolic process TAS--

    NUDT15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NUDT15 (NUD15)

    8 HMDB Compounds for NUDT15    About this table
    CompoundSynonyms CAS #PubMed Ids
    8-Oxo-dGMP8OG;8-Oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate ----
    8-Oxo-dGTP2'-deoxy-7,8-dihydro-8-oxo-Guanosine 5'-(tetrahydrogen triphosphate) (see all 6)139307-94-1--
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    CDPCDP (see all 3)63-38-7--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--
    dTDPDeoxy-tdp (see all 5)491-97-4--

    Search CenterWatch for drugs/clinical trials and news about NUDT15 / NUD15

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NUDT15 gene: 
    NM_018283.1  

    Unigene Cluster for NUDT15:

    Nudix (nucleoside diphosphate linked moiety X)-type motif 15
    Hs.144407  [show with all ESTs]
    Unigene Representative Sequence: AK001818
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000258662(uc001vbv.3 uc001vbw.1)
    miRNA
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    4 QIAGEN miScript miRNA Assays for microRNAs that regulate NUDT15:
    hsa-miR-338-5p hsa-miR-3065-5p hsa-miR-488 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidNUDT15 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NUDT15
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUDT15
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NUDT15 (NM_018283)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUDT15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUDT15
    Sirion Biotech Customized lentivirus for stable overexpression of NUDT15 
                         Customized lentivirus expression plasmids for stable overexpression of NUDT15 
    Primer
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    OriGene qPCR primer pairs and template standards for NUDT15
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUDT15
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUDT15

    Additional mRNA sequence: 

    AK001818.1 BC050698.1 BC064607.1 BC107875.1 BC133015.1 BC133017.1 

    7 DOTS entries:

    DT.426749  DT.97772552  DT.99996793  DT.100767198  DT.100019246  DT.40122269  DT.92433503 

    24/70 AceView cDNA sequences (see all 70):

    AK001818 AU134750 AL546804 CR599539 BM465681 BU676361 AI350437 AW149964 
    AW512792 BC050698 BQ787890 BU190450 CF886861 BU622058 AA622208 NM_018283 
    BG251804 AW518502 AW002750 BC064607 AI819928 CD644513 BX506009 BG676426 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NUDT15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTATGCAGA
    NUDT15 Expression
    About this image


    See NUDT15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NUDT15

    SOURCE GeneReport for Unigene cluster: Hs.144407
        SABiosciences Expression via Pathway-Focused PCR Arrays including NUDT15: 
              Nitric Oxide Signaling Pathway in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NUDT15 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nudt151 , 5 nudix (nucleoside diphosphate linked moiety X)-type more1, 5 84.05(n)1
    89.57(a)1
      14 (39.06 cM)5
    2142541  NM_172527.21  NP_766115.11 
     735198645 
    chicken
    (Gallus gallus)
    Aves NUDT151 nudix (nucleoside diphosphate linked moiety X)-type more 64.72(n)
    68.18(a)
      418858  XM_417053.3  XP_417053.3 
    lizard
    (Anolis carolinensis)
    Reptilia NUDT156
    Uncharacterized protein
    71(a)
    1 ↔ 1
    1(136977529-136982154)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3986402 hypothetical protein LOC398640 72.73(n)    BC054313.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nudt151 nudix (nucleoside diphosphate linked moiety X)-type more 61.26(n)
    57.43(a)
      415197  NM_001002107.1  NP_001002107.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons NUDX11 nudix hydrolase 1 50.78(n)
    45.31(a)
      843207  NM_105549.3  NP_177044.1 


    ENSEMBL Gene Tree for NUDT15 (if available)
    TreeFam Gene Tree for NUDT15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NUDT15 gene

    NUDT15 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for NUDT15
    PGOHUM00000237029 PGOHUM00000249354


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/286 SNPs in NUDT15 are shown (see all 286)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1875906281,2
    --48609896(+) GCTTTC/TTAATT 1 -- us2k10--------
    rs2009835521,2
    --48609916(+) GATTG-/TTTTTA 1 -- us2k10--------
    rs1455872331,2
    C--48609921(+) GTTTT-/AAAAAA 1 -- us2k10--------
    rs1920081751,2
    --48609921(+) GTTTTA/TAAAAA 1 -- us2k10--------
    rs770331331,2
    F--48609969(+) TTTTAT/CTGATT 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs2000446571,2
    C--48610119(-) GGCTTG/TATACT 1 -- us2k10--------
    rs1381165701,2
    --48610182(+) ACAATA/TCTGGA 1 -- us2k10--------
    rs1428041811,2
    C--48610284(+) ATCATA/GCAGTC 1 -- us2k10--------
    rs1141332261,2
    C,F--48610292(+) GTCTTC/TCAATA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1460586901,2
    --48610346(+) AGTCAC/TAACAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NUDT15 (48611703 - 48621358 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NUDT15:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832601CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NUDT15
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for NUDT15:    About MalaCards
    myelitis    


    NUDT15 for disorders           About GeneDecksing


    Export disorders for NUDT15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NUDT15 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with NUDT15)
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    1. Proliferating cell nuclear antigen is protected from degradation by forming a complex with MutT Homolog2. (PubMed id 19419956)1, 2, 9 Yu Y.... Zhu W.-G. (2009)
    2. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Mouse MTH2 protein which prevents mutations caused by 8-oxoguanine nucleotides. (PubMed id 12767940)1, 3 Cai J.P....Sekiguchi M. (2003)
    6. Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2. (PubMed id 22556419)2 Takagi Y....Sekiguchi M. (2012)
    7. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Suppression of mutagenesis by 8-hydroxy-2'-deoxyguano sine 5'-triphosphate (7,8-dihydro-8-oxo-2'-deoxyguanosine 5'-triphosphate) by h uman MTH1, MTH2, and NUDT5. (PubMed id 20144704)1 Hori M....Kamiya H. (2010)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55270 HGNC: 23063 AceView: NUDT15 Ensembl:ENSG00000136159 euGenes: HUgn55270
    ECgene: NUDT15 H-InvDB: NUDT15

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NUDT15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NUDT15 gene:
    Search GeneIP for patents involving NUDT15

    GeneCards and IP:
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