NUDT15 Gene
protein-coding GIFtS: 47
GCID: GC13P048611
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nudix (nucleoside diphosphate linked moiety X)-type motif...
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Aliases
for NUDT15 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 151 2 | | FLJ109561 | | MTH21 2 3 | | A730068G11Rik2 | | MutT Homolog 22 3 | | RP11-90M2.12 | | Nucleoside Diphosphate-Linked Moiety X Motif 152 3 | | Nudix-Type Motif 152 | | Nudix Motif 152 3 | | Probable 7,8-Dihydro-8-Oxoguanine Triphosphatase NUDT152 | | 7,8-Dihydro-8-Oxoguanine-Triphosphatase NUDT152 3 | | Probable 8-Oxo-DGTP Diphosphatase NUDT152 | | 8-Oxo-DGTPase NUDT152 3 | | EC 3.6.1.553 |
Export aliases for NUDT15 gene to outside databasesPrevious GC identifers: GC13P046409 GC13P047509 GC13P029404 |
Summaries
for NUDT15 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: NUD15_HUMAN, Q9NV35Function: Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro,suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and thenucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions.Its substrate specificity in vivo however remains unclear (By similarity). May have a role in DNA synthesis and cellcycle progression through the interaction with PCNA
|
Genomic Views
for NUDT15 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_024524.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NUDT15 gene promoter:
AP-1 p300 NCX/Ncx HTF STAT5A E4BP4 LCR-F1 S8 c-Myb Hlf
Other transcription factors
Search SABiosciences Chromatin IP Primers for NUDT15
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUDT15 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q14.2 Ensembl cytogenetic band: 13q14.2 HGNC cytogenetic band: 13q14.12NUDT15 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13P048611: view genomic region
(about GC identifiers)
Start:
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48,611,703 bp from pter |
End:
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48,621,282 bp from pter |
Size:
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9,580 bases |
Orientation:
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plus strand |
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Proteins
for NUDT15 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NUD15_HUMAN, Q9NV35 (See
protein sequence)Recommended Name: Probable 8-oxo-dGTP diphosphatase NUDT15 Size: 164 amino acids; 18609 Da
Cofactor: Magnesium or manganese. Magnesium may be the real cofactor in vivo (By similarity)
Subunit: Interacts with PCNA; interaction is disrupted in response to UV irradiation
Secondary accessions: A2RUR6 Q32Q27 Q6P2C9Explore the universe of human proteins at neXtProt for NUDT15: NX_Q9NV35
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NV35
NUDT15 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060753.1
ENSEMBL proteins: ENSP00000258662 Reactome Protein details: Q9NV35
Human Recombinant Protein Products:
NUDT15 Antibody Products:
Assay Products for NUDT15: |
Protein
Domains /
Families
for NUDT15 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NUDT15 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NV35ProtoNet protein and cluster: Q9NV35 1 Blocks protein family: IPB000086 NUDIX hydrolase
UniProtKB/Swiss-Prot: NUD15_HUMAN, Q9NV35Similarity: Belongs to the Nudix hydrolase familySimilarity: Contains 1 nudix hydrolase domain |
Function
for NUDT15 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NUD15_HUMAN, Q9NV35Function: Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro,suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and thenucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions.Its substrate specificity in vivo however remains unclear (By similarity). May have a role in DNA synthesis and cellcycle progression through the interaction with PCNACatalytic activity: 8-oxo-dGTP + H(2)O = 8-oxo-dGMP + diphosphateEnzyme Number (IUBMB): EC 3.6.1.551
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT15
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for NUDT15 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUDT15 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT15 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008413 | 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity |
IDA | -- | | GO:0016787 | hydrolase activity |
-- | -- | | GO:0035539 | 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity |
IDA | -- | | GO:0046872 | metal ion binding |
IEA | -- |
NUDT15 for ontologies About GeneDecksing
|
Pathways & Interactions
for NUDT15 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Phosphate bond hydrolysis by NUDT proteins | | | 2 | Metabolism | | | 3 | Purine metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 
Reactome Pathways for NUDT15
NUDT15 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NUDT15
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for NUDT15 (ENSP000002586624) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006184 | GTP catabolic process |
IDA | -- | | GO:0006203 | dGTP catabolic process |
IDA | -- |
NUDT15 for ontologies About GeneDecksing
|
Drugs & Compounds
for NUDT15 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NUDT15
8 HMDB Compounds for NUDT15 About this table
Search CenterWatch for drugs/clinical trials and news about NUDT15 / NUD15
|
Transcripts
for NUDT15 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NUDT15 gene: NM_018283.1 Unigene Cluster for NUDT15: Nudix (nucleoside diphosphate linked moiety X)-type motif 15 Hs.144407 [show with all ESTs]Unigene Representative Sequence: AK0018181 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000258662(uc001vbv.3 uc001vbw.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT15 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT15
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NUDT15 (NM_018283) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NUDT15 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUDT15 |
Additional cDNA sequence: AK001818.1 BC050698.1 BC064607.1 BC107875.1 BC133015.1 BC133017.1 7 DOTS entries: DT.426749 DT.97772552 DT.99996793 DT.100767198 DT.100019246 DT.40122269 DT.92433503 24/70 AceView cDNA sequences (see all 70): BG251804 NM_018283 BC064607 AK001818 AL546804 BU190450 BU676361 CF886861 AW518502 CR599539 AW002750 AI350437 AW149964 BU622058 AU134750 AW512792 BQ787890 BC050698 AA622208 BM465681 AI669204 CD644513 AW471254 AI819928
GeneLoc Exon Structure
|
Expression
for NUDT15 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NUDT15 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGTATGCAGA
About this image
See NUDT15 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NUDT15
SOURCE GeneReport for Unigene cluster: Hs.144407
SABiosciences Expression via Pathway-Focused PCR Arrays including NUDT15: | Nitric Oxide Signaling Pathway in human mouse rat | | Molecular Toxicology PathwayFinder 384HT in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUDT15
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NUDT15 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUDT15 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUDT15 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT15 |
Orthologs
for NUDT15 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for NUDT15 gene from 6/18 species (see all 18) About this table
ENSEMBL Gene Tree for NUDT15 (if available)
TreeFam Gene Tree for NUDT15 (if available) |
Paralogs
for NUDT15 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NUDT15 gene
NUDT15 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for NUDT15
PGOHUM00000237029 PGOHUM00000249354
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Genomic Variants
for NUDT15 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NUDT15 (48611703 - 48621282 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for NUDT15
1 CNV: 4803 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NUDT15 |
|
Disorders
/ Diseases
for NUDT15 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NUDT15 for disorders About GeneDecksing
1  disease for NUDT15: About MalaCardsmyelitis
Export disorders for NUDT15 gene to outside databases
|
Publications
for NUDT15 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NUDT15 gene integrated from 9 sources:
(articles sorted by number of sources associating them with NUDT15) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Proliferating cell nuclear antigen is protected from degradation by forming a complex with MutT Homolog2. (PubMed id 19419956)1, 2, 9 Yu Y.... Zhu W.-G. (2009)
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Mouse MTH2 protein which prevents mutations caused by 8-oxoguanine nucleotides. (PubMed id 12767940)1, 3 Cai J.P....Sekiguchi M. (2003)
- Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2. (PubMed id 22556419)2 Takagi Y....Sekiguchi M. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Suppression of mutagenesis by 8-hydroxy-2'-deoxyguano sine 5'-triphosphate (7,8-dihydro-8-oxo-2'-deoxyguanosine 5'-triphosphate) by h uman MTH1, MTH2, and NUDT5. (PubMed id 20144704)1 Hori M....Kamiya H. (2010)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for NUDT15 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NUDT15 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NUDT15 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NUDT15 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NUDT15 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NUDT15 gene:
Search GeneIP for patents involving NUDT15
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NUDT15 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NUDT15 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NUDT15 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUDT15 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUDT15 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUDT15 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUDT15 |
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 |  |  |  | |
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| |  |  |  |  | | | | |
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 | | | NUDT15 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT15 |
|  |  |  | | | | ThermoFisher Antibody for NUDT15 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUDT15 |
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