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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NUDT14 Gene

protein-coding   GIFtS: 45
GCID: GC14M105639

Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif...

  Search for NUDT14
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 141 2     Uridine Diphosphate Glucose Pyrophosphatase2
UGPP2 3     EC 3.6.1.453
UGPPase2 3     Nucleoside Diphosphate-Linked Moiety X Motif 143
UDPG Pyrophosphatase2 3     Nudix Motif 143
UDP-Sugar Diphosphatase2     

External Ids:    HGNC: 201411   Entrez Gene: 2562812   Ensembl: ENSG000001838287   OMIM: 6092195   UniProtKB: O958483   

Export aliases for NUDT14 gene to outside databases

Previous GC identifers: GC14M099630 GC14M103610 GC14M104710 GC14M085831


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NUDT14 Gene:
UDP-glucose (UDPG) acts as the sugar donor in numerous glycosylation reactions, including those involved in the
production of glycogen. NUDT14 is a UDPG pyrophosphatase (EC 3.6.1.45) that hydrolyzes UDPG to produce glucose
1-phosphate and UMP (Yagi et al., 2003 (PubMed 12429023)).(supplied by OMIM, Mar 2008)

GeneCards Summary for NUDT14 Gene: 
NUDT14 (nudix (nucleoside diphosphate linked moiety X)-type motif 14) is a protein-coding gene. GO annotations related to this gene include ADP-ribose diphosphatase activity and UDP-sugar diphosphatase activity.

UniProtKB/Swiss-Prot: NUD14_HUMAN, O95848
Function: Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The
physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose,
CDP-glucose, GDP-glucose and GDP-mannose




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NUDT14 gene promoter:
         USF1   Elk-1   Pax-5   MyoD   USF2   USF-1:USF-2   c-Ets-1   HEN1   USF-1   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNUDT14 promoter sequence
   Search SABiosciences Chromatin IP Primers for NUDT14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUDT14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.33

NUDT14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUDT14 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M105639:  view genomic region     (about GC identifiers)

Start:
105,639,275 bp from pter      End:
105,647,660 bp from pter
Size:
8,386 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NUD14_HUMAN, O95848 (See protein sequence)
Recommended Name: Uridine diphosphate glucose pyrophosphatase  
Size: 222 amino acids; 24118 Da
Cofactor: Magnesium
Subunit: Homodimer
Subcellular location: Cytoplasm
Sequence caution: Sequence=AAD15563.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for NUDT14:
3Q91 (3D)    
Secondary accessions: Q86SJ8

Explore the universe of human proteins at neXtProt for NUDT14: NX_O95848

Explore proteomics data for NUDT14 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95848

  • NUDT14 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NUDT14 Protein Expression
    REFSEQ proteins: NP_803877.2  
    ENSEMBL proteins: 
     ENSP00000376349   ENSP00000447933  

    Human Recombinant Protein Products for NUDT14: 
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    Cloud-Clone Corp. Proteins for NUDT14 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    NUDT14 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    NUDT: Nudix motif containing

    3 InterPro protein domains:
     IPR015797 NUDIX_hydrolase_dom-like
     IPR004385 NDP_pyrophosphatase
     IPR000086 NUDIX_hydrolase_dom

    Graphical View of Domain Structure for InterPro Entry O95848

    ProtoNet protein and cluster: O95848

    1 Blocks protein domain: IPB000086 NUDIX hydrolase

    UniProtKB/Swiss-Prot: NUD14_HUMAN, O95848
    Similarity: Belongs to the Nudix hydrolase family
    Similarity: Contains 1 nudix hydrolase domain


    NUDT14 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NUD14_HUMAN, O95848
    Function: Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The
    physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose,
    CDP-glucose, GDP-glucose and GDP-mannose
    Catalytic activity: UDP-sugar + H(2)O = UMP + alpha-D-aldose 1-phosphate
    Biophysicochemical properties: pH dependence: Optimum pH is 8.0-9.5;

         Enzyme Number (IUBMB): EC 3.6.1.451

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12620389
    GO:0008768UDP-sugar diphosphatase activity IEA--
    GO:0016787hydrolase activity ----
    GO:0016818hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides ----
    GO:0046872metal ion binding IEA--
         
    NUDT14 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NUDT14

    2 Interacting proteins for NUDT14 (O958481, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARAFP103981, 3EBI-536866,EBI-365961 I2D: score=3 
    RAF1P040493I2D: score=3 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NUDT14 (NUD14)

    6 HMDB Compounds for NUDT14    About this table
    CompoundSynonyms CAS #PubMed Ids
    GDP-glucoseGDP-alpha-D-glucose (see all 7)5750-57-2--
    Glucose 1-phosphateCori ester (see all 22)59-56-3--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Uridine 5'-monophosphate5'-UMP (see all 12)58-97-9--
    Uridine diphosphate glucose(UPD)-glucose (see all 24)133-89-1--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Search CenterWatch for drugs/clinical trials and news about NUDT14 / NUD14

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NUDT14 gene: 
    NM_177533.4  

    Unigene Cluster for NUDT14:

    Nudix (nucleoside diphosphate linked moiety X)-type motif 14
    Hs.526432  [show with all ESTs]
    Unigene Representative Sequence: BQ068667
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000550912 ENST00000392568 ENST00000551024 ENST00000550002 ENST00000339418
    ENST00000546553
    miRNA
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    Additional mRNA sequence: 

    AB087802.1 AK310449.1 BC041584.1 

    6 DOTS entries:

    DT.214342  DT.91854342  DT.75150758  DT.97839199  DT.100751072  DT.120762358 

    4 AceView cDNA sequences:

    NM_177533 AB087802 BC041584 AK128196 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for NUDT14    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
    SP1:                                                                  
    SP2:                          -                       -     -         
    SP3:                          -                       -               
    SP4:                          -                                       


    ECgene alternative splicing isoforms for NUDT14

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NUDT14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTCCTCAGC
    NUDT14 Expression
    About this image


    See NUDT14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NUDT14

    SOURCE GeneReport for Unigene cluster: Hs.526432
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NUDT14 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nudt141 , 5 nudix (nucleoside diphosphate linked moiety X)-type more1, 5 82.13(n)1
    82.43(a)1
      12 (61.42 cM)5
    661741  NM_025399.31  NP_079675.11 
     1129347335 
    chicken
    (Gallus gallus)
    Aves NUDT141 nudix (nucleoside diphosphate linked moiety X)-type more 59.82(n)
    55.25(a)
      423501  NM_001006490.1  NP_001006490.1 
    lizard
    (Anolis carolinensis)
    Reptilia NUDT146
    nudix (nucleoside diphosphate linked moiety X)-typ...
    55(a)
    1 ↔ 1
    1(264453-286857)
    zebrafish
    (Danio rerio)
    Actinopterygii nudt141 nudix (nucleoside diphosphate linked moiety X)-type more 62.64(n)
    57.67(a)
      559149  NM_001044888.1  NP_001038353.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG428131 CG42813 57.99(n)
    46.35(a)
      43276  NM_170323.2  NP_733202.2 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_C50F4.161 Protein C50F4.16 43.59(n)
    34.87(a)
      179337  NM_073060.3  NP_505461.1 


    ENSEMBL Gene Tree for NUDT14 (if available)
    TreeFam Gene Tree for NUDT14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/218 SNPs in NUDT14 are shown (see all 218)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs795475661,2
    C,F--105638781(+) TACTGG/TGGCCC 1 -- ds50011Minor allele frequency- T:0.13EA 120
    rs1915878751,2
    --105638798(+) CAGGGC/TAGCTT 1 -- ds50010--------
    rs38257611,2
    C,F,A,H--105638931(-) GAGTTG/AGGATG 1 -- ds500126Minor allele frequency- A:0.34NS EA NA WA CSA 2341
    rs1167447191,2
    F--105638936(+) TAACTC/TCTGAG 1 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1812771901,2
    --105638964(+) CTCTCA/GTGAGC 1 -- ds50010--------
    rs71515941,2
    C,F,A,H--105639041(+) GTCCCA/GGACCC 1 -- ds500120Minor allele frequency- G:0.41NS EA NA WA CSA 980
    rs1172078271,2
    C,F--105639079(+) CAGCCT/CGGCCC 1 -- ds50011Minor allele frequency- C:0.04EA 120
    rs1449718151,2
    C--105639120(+) CCCCAC/TAGCAA 1 -- ds50010--------
    rs619961611,2
    C,F--105639175(+) TCGCCG/CTGTCC 1 -- ds50018Minor allele frequency- C:0.41NA WA CSA EA 368
    rs1158698811,2
    C,F--105639278(+) AGCTGG/AAGCTA 1 -- ut311Minor allele frequency- A:0.15WA 118

    HapMap Linkage Disequilibrium report for NUDT14 (105639275 - 105647660 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/23 variations for NUDT14 (see all 23):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv2021n71CNV Loss21882294
    dgv2025n71CNV Loss21882294
    dgv2029n71CNV Loss21882294
    dgv2028n71CNV Loss21882294
    nsv902441CNV Loss21882294
    nsv902433CNV Loss21882294
    dgv2022n71CNV Loss21882294
    dgv2020n71CNV Loss21882294
    dgv2024n71CNV Loss21882294
    nsv902424CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NUDT14 for disorders           About MalaCards
    OMIM gene information: 609219    OMIM disorders: --


    NUDT14 for disorders           About GeneDecksing


    Export disorders for NUDT14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NUDT14 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with NUDT14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression and characterization of a mammalian Nudix hydrolase-like enzyme that cleaves the pyrophosphate bond of UDP- glucose. (PubMed id 12429023)1, 2, 3, 9 Yagi T.... Pozueta-Romero J. (2003)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
    4. Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    6. Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis. (PubMed id 12620389)1 Yuryev A. and Wennogle L.P. (2003)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene. (PubMed id 10662552)2 Deng Y....Li L. (2000)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 256281 HGNC: 20141 AceView: NUDT14 Ensembl:ENSG00000183828 euGenes: HUgn256281
    ECgene: NUDT14 H-InvDB: NUDT14

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NUDT14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NUDT14 gene:
    Search GeneIP for patents involving NUDT14

    GeneCards and IP:
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