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Aliases for NUDT14 Gene

Aliases for NUDT14 Gene

  • Nudix Hydrolase 14 2 3 5
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 14 2 3
  • UDPG Pyrophosphatase 3 4
  • UGPPase 3 4
  • UGPP 3 4
  • Nucleoside Diphosphate-Linked Moiety X Motif 14 4
  • Uridine Diphosphate Glucose Pyrophosphatase 2
  • UDP-Sugar Diphosphatase 3
  • Nudix Motif 14 4
  • EC 4

External Ids for NUDT14 Gene

Previous GeneCards Identifiers for NUDT14 Gene

  • GC14M099630
  • GC14M103610
  • GC14M104710
  • GC14M105639
  • GC14M085831

Summaries for NUDT14 Gene

Entrez Gene Summary for NUDT14 Gene

  • The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This enzyme contains a Nudix hydrolase domain and is a UDPG pyrophosphatase that hydrolyzes UDPG to produce glucose 1-phosphate and UMP. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

GeneCards Summary for NUDT14 Gene

NUDT14 (Nudix Hydrolase 14) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Synthesis of substrates in N-glycan biosythesis. GO annotations related to this gene include hydrolase activity and ADP-ribose diphosphatase activity.

UniProtKB/Swiss-Prot for NUDT14 Gene

  • Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT14 Gene

Genomics for NUDT14 Gene

Regulatory Elements for NUDT14 Gene

Enhancers for NUDT14 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NUDT14 on UCSC Golden Path with GeneCards custom track

Promoters for NUDT14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NUDT14 on UCSC Golden Path with GeneCards custom track

Genomic Location for NUDT14 Gene

105,172,937 bp from pter
105,181,323 bp from pter
8,387 bases
Minus strand

Genomic View for NUDT14 Gene

Genes around NUDT14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDT14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDT14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT14 Gene

Proteins for NUDT14 Gene

  • Protein details for NUDT14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uridine diphosphate glucose pyrophosphatase
    Protein Accession:
    Secondary Accessions:
    • Q86SJ8

    Protein attributes for NUDT14 Gene

    222 amino acids
    Molecular mass:
    24118 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer.
    • Sequence=AAD15563.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NUDT14 Gene

neXtProt entry for NUDT14 Gene

Proteomics data for NUDT14 Gene at MOPED

Post-translational modifications for NUDT14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUDT14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NUDT14 Gene

Domains & Families for NUDT14 Gene

Gene Families for NUDT14 Gene

Protein Domains for NUDT14 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 nudix hydrolase domain.
  • Belongs to the Nudix hydrolase family.
  • Contains 1 nudix hydrolase domain.
  • Belongs to the Nudix hydrolase family.
genes like me logo Genes that share domains with NUDT14: view

Function for NUDT14 Gene

Molecular function for NUDT14 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 8.0-9.5.;
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-sugar + H(2)O = UMP + alpha-D-aldose 1-phosphate.
UniProtKB/Swiss-Prot Function:
Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose.

Enzyme Numbers (IUBMB) for NUDT14 Gene

Gene Ontology (GO) - Molecular Function for NUDT14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12620389
GO:0008768 UDP-sugar diphosphatase activity IEA,TAS --
GO:0016787 hydrolase activity IEA --
GO:0047631 ADP-ribose diphosphatase activity IEA --
genes like me logo Genes that share ontologies with NUDT14: view
genes like me logo Genes that share phenotypes with NUDT14: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NUDT14 Gene

Localization for NUDT14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDT14 Gene


Subcellular locations from

Jensen Localization Image for NUDT14 Gene COMPARTMENTS Subcellular localization image for NUDT14 gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for NUDT14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NUDT14: view

Pathways & Interactions for NUDT14 Gene

genes like me logo Genes that share pathways with NUDT14: view

Gene Ontology (GO) - Biological Process for NUDT14 Gene


No data available for SIGNOR curated interactions for NUDT14 Gene

Drugs & Compounds for NUDT14 Gene

(3) Drugs for NUDT14 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glucose 1-phosphate Experimental Pharma 0
Uridine-5'-Monophosphate Experimental Pharma 0
Magnesium Nutra 0

(3) Additional Compounds for NUDT14 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • GDP-alpha-D-Glucose
  • GDP-alpha-delta-Glucose
  • GDPG
  • Guanosine 5-pyrophosphate
  • Guanosine diphosphoglucose
Uridine diphosphate glucose
  • (UDP)glucose
  • (UPD)-glucose
  • UDP Glucose
  • UDP-a-D-Glucose
  • UDP-alpha-D-Glucose
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with NUDT14: view

Transcripts for NUDT14 Gene

mRNA/cDNA for NUDT14 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NUDT14 Gene

Nudix (nucleoside diphosphate linked moiety X)-type motif 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT14 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
SP2: - - -
SP3: - -
SP4: -

Relevant External Links for NUDT14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NUDT14 Gene

mRNA expression in normal human tissues for NUDT14 Gene

Protein differential expression in normal tissues from HIPED for NUDT14 Gene

This gene is overexpressed in Oral epithelium (8.2), Brain (6.1), and Tonsil (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUDT14 Gene

SOURCE GeneReport for Unigene cluster for NUDT14 Gene Hs.526432

genes like me logo Genes that share expression patterns with NUDT14: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NUDT14 Gene

Orthologs for NUDT14 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUDT14 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NUDT14 35
  • 86.19 (n)
  • 85.59 (a)
NUDT14 36
  • 85 (a)
(Canis familiaris)
Mammalia LOC612707 35
  • 85.66 (n)
  • 87.05 (a)
NUDT14 36
  • 85 (a)
(Mus musculus)
Mammalia Nudt14 35
  • 82.13 (n)
  • 82.43 (a)
Nudt14 16
Nudt14 36
  • 82 (a)
(Pan troglodytes)
Mammalia NUDT14 35
  • 99.4 (n)
  • 99.55 (a)
NUDT14 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Nudt14 35
  • 82.43 (n)
  • 83.78 (a)
(Ornithorhynchus anatinus)
Mammalia NUDT14 36
  • 44 (a)
(Gallus gallus)
Aves NUDT14 35
  • 59.82 (n)
  • 55.25 (a)
NUDT14 36
  • 53 (a)
(Anolis carolinensis)
Reptilia NUDT14 36
  • 55 (a)
(Danio rerio)
Actinopterygii nudt14 35
  • 62.25 (n)
  • 56.62 (a)
nudt14 36
  • 50 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004158 35
  • 52.75 (n)
  • 46.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42813 35
  • 58.51 (n)
  • 47.4 (a)
CG42813 36
  • 43 (a)
CG42814 36
  • 33 (a)
(Caenorhabditis elegans)
Secernentea CELE_C50F4.16 35
  • 42.51 (n)
  • 33.82 (a)
C50F4.16 36
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
Species with no ortholog for NUDT14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NUDT14 Gene

Gene Tree for NUDT14 (if available)
Gene Tree for NUDT14 (if available)

Paralogs for NUDT14 Gene

No data available for Paralogs for NUDT14 Gene

Variants for NUDT14 Gene

Sequence variations from dbSNP and Humsavar for NUDT14 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs8017877 -- 105,180,133(+) CGGCC(C/T)GGGAC intron-variant
rs8018223 -- 105,180,314(+) ttaaa(A/C)attag intron-variant
rs10139450 -- 105,177,315(+) AGCTG(A/C)GGCCG intron-variant
rs10139596 -- 105,177,282(+) CACAC(A/G)GGCAG intron-variant
rs10139839 -- 105,177,639(+) GTCCC(C/T)GTAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUDT14 Gene

Variant ID Type Subtype PubMed ID
dgv2020n71 CNV Loss 21882294
nsv456458 CNV Loss 19166990
nsv902424 CNV Loss 21882294
nsv902425 CNV Loss 21882294
nsv9175 CNV Gain 18304495
dgv659e1 CNV Complex 17122850
dgv2021n71 CNV Loss 21882294
nsv470679 CNV Loss 18288195
nsv902433 CNV Loss 21882294
dgv2022n71 CNV Loss 21882294
nsv902435 CNV Gain+Loss 21882294
dgv2023n71 CNV Gain+Loss 21882294
nsv902441 CNV Loss 21882294
dgv2024n71 CNV Loss 21882294
dgv2025n71 CNV Loss 21882294
nsv517055 CNV Gain+Loss 19592680
nsv817646 CNV Loss 17921354
dgv267n27 CNV Loss 19166990
dgv2026n71 CNV Gain 21882294
dgv2027n71 CNV Gain+Loss 21882294
dgv2028n71 CNV Loss 21882294
dgv2029n71 CNV Loss 21882294
dgv2030n71 CNV Loss 21882294

Variation tolerance for NUDT14 Gene

Residual Variation Intolerance Score: 61.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.54; 29.80% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NUDT14 Gene

Disorders for NUDT14 Gene

Relevant External Links for NUDT14

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NUDT14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUDT14 Gene

Publications for NUDT14 Gene

  1. Cloning, expression and characterization of a mammalian Nudix hydrolase-like enzyme that cleaves the pyrophosphate bond of UDP- glucose. (PMID: 12429023) Yagi T. … Pozueta-Romero J. (Biochem. J. 2003) 2 3 4 23 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  4. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PMID: 21044950) Lee O.H. … Songyang Z. (Mol. Cell Proteomics 2011) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for NUDT14 Gene

Sources for NUDT14 Gene