NUDT14 Gene
protein-coding GIFtS: 44
GCID: GC14M105639
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nudix (nucleoside diphosphate linked moiety X)-type motif...
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Aliases
for NUDT14 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 141 2 | | Uridine Diphosphate Glucose Pyrophosphatase2 | | UGPP1 2 3 | | EC 3.6.1.453 | | UGPPase2 3 | | Nucleoside Diphosphate-Linked Moiety X Motif 143 | | UDPG Pyrophosphatase2 3 | | Nudix Motif 143 | | UDP-Sugar Diphosphatase2 | | |
Export aliases for NUDT14 gene to outside databasesPrevious GC identifers: GC14M099630 GC14M103610 GC14M104710 GC14M085831 |
Summaries
for NUDT14 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NUDT14:
UDP-glucose (UDPG) acts as the sugar donor in numerous glycosylation reactions, including those involved in theproduction of glycogen. NUDT14 is a UDPG pyrophosphatase (EC 3.6.1.45) that hydrolyzes UDPG to produce glucose1-phosphate and UMP (Yagi et al., 2003 (PubMed 12429023)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: NUD14_HUMAN, O95848Function: Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. Thephysiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose,GDP-glucose and GDP-mannose
|
Genomic Views
for NUDT14 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NUDT14 gene promoter:
USF1 Elk-1 Pax-5 MyoD USF2 USF-1:USF-2 c-Ets-1 HEN1 USF-1 TGIF
Other transcription factors
Search SABiosciences Chromatin IP Primers for NUDT14
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUDT14 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q32.33 Ensembl cytogenetic band: 14q32.33 HGNC cytogenetic band: 14q32.33NUDT14 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M105639: view genomic region
(about GC identifiers)
Start:
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105,639,275 bp from pter |
End:
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105,647,660 bp from pter |
Size:
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8,386 bases |
Orientation:
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minus strand |
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Proteins
for NUDT14 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NUD14_HUMAN, O95848 (See
protein sequence)Recommended Name: Uridine diphosphate glucose pyrophosphatase Size: 222 amino acids; 24118 Da
Cofactor: Magnesium
Subunit: Homodimer
Subcellular location: Cytoplasm
Sequence caution: Sequence=AAD15563.1; Type=Erroneous initiation;
1 PDB 3D structure from  and Proteopedia  for NUDT14:3Q91 (3D)
Secondary accessions: Q86SJ8Explore the universe of human proteins at neXtProt for NUDT14: NX_O95848
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O95848
NUDT14 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_803877.2
ENSEMBL proteins: ENSP00000376349 ENSP00000447933
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
NUDT14 for ontologies About GeneDecksing
NUDT14 Antibody Products:
Assay Products for NUDT14: |
Protein
Domains /
Families
for NUDT14 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NUDT14 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O95848ProtoNet protein and cluster: O95848 1 Blocks protein family: IPB000086 NUDIX hydrolase
UniProtKB/Swiss-Prot: NUD14_HUMAN, O95848Similarity: Belongs to the Nudix hydrolase familySimilarity: Contains 1 nudix hydrolase domain |
Function
for NUDT14 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NUD14_HUMAN, O95848Function: Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. Thephysiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose,GDP-glucose and GDP-mannoseCatalytic activity: UDP-sugar + H(2)O = UMP + alpha-D-aldose 1-phosphateBiophysicochemical properties: pH dependence: Optimum pH is 8.0-9.5;Enzyme Number (IUBMB): EC 3.6.1.451
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT14
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Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
NUDT14 for ontologies About GeneDecksing
|
Pathways & Interactions
for NUDT14 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NUDT14
2 Interacting proteins for NUDT14 (O958481, 3) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for NUDT14 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NUDT14
6 HMDB Compounds for NUDT14 About this table
Search CenterWatch for drugs/clinical trials and news about NUDT14 / NUD14
|
Transcripts
for NUDT14 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NUDT14 gene: NM_177533.4 Unigene Cluster for NUDT14: Nudix (nucleoside diphosphate linked moiety X)-type motif 14 Hs.526432 [show with all ESTs]Unigene Representative Sequence: BQ0686677 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000550912 ENST00000392568 ENST00000550579(uc010tyn.2 uc001yqi.3)
ENST00000551024 ENST00000550002 ENST00000339418 ENST00000546553
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT14 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT14
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NUDT14 (NM_177533) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NUDT14 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUDT14 |
Additional cDNA sequence: AB087802.1 AK310449.1 BC041584.1 6 DOTS entries: DT.214342 DT.91854342 DT.75150758 DT.97839199 DT.100751072 DT.120762358 4 AceView cDNA sequences: AB087802 BC041584 NM_177533 AK128196
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for NUDT14 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | - | | - | | | | |
| SP3: | | | | | | | | | - | | | | | | | | - | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NUDT14
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Expression
for NUDT14 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NUDT14 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTCCTCAGC
About this image
Genevestigator expression for NUDT14
SOURCE GeneReport for Unigene cluster: Hs.526432
SABiosciences Custom PCR Arrays for NUDT14
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUDT14
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NUDT14 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUDT14 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUDT14 |
Orthologs
for NUDT14 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for NUDT14 gene from 6/20 species (see all 20) About this table
ENSEMBL Gene Tree for NUDT14 (if available)
TreeFam Gene Tree for NUDT14 (if available) |
Paralogs
for NUDT14 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for NUDT14 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NUDT14 (105639275 - 105647660 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for NUDT14
7 CNVs: 10453 3950 53303 29968 29967 29966 30666 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NUDT14 |
|
Disorders
/ Diseases
for NUDT14 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 NUDT14 for disorders About MalaCards
NUDT14 for disorders About GeneDecksing
OMIM gene information: 609219
OMIM disorders: --
Export disorders for NUDT14 gene to outside databases
|
Publications
for NUDT14 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NUDT14 gene integrated from 9 sources:
(articles sorted by number of sources associating them with NUDT14) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning, expression and characterization of a mammalian Nudix hydrolase-like enzyme that cleaves the pyrophosphate bond of UDP- glucose. (PubMed id 12429023)1, 2, 3, 9 Yagi T.... Pozueta-Romero J. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
- Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis. (PubMed id 12620389)1 Yuryev A. and Wennogle L.P. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene. (PubMed id 10662552)2 Deng Y....Li L. (2000)
|
External Searches for NUDT14 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NUDT14 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NUDT14 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NUDT14 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NUDT14 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NUDT14 gene:
Search GeneIP for patents involving NUDT14
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NUDT14 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | NUDT14 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for NUDT14 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUDT14 |
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