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Aliases for NUDT13 Gene

Aliases for NUDT13 Gene

  • Nudix Hydrolase 13 2 3 5
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 13 2
  • Protein KiSS-16 4
  • Nudix Motif 13 4
  • EC 3.-.-.- 4

External Ids for NUDT13 Gene

Previous GeneCards Identifiers for NUDT13 Gene

  • GC10P073648
  • GC10M073973
  • GC10P074762
  • GC10P074214
  • GC10P074540
  • GC10P074870
  • GC10P068863

Summaries for NUDT13 Gene

GeneCards Summary for NUDT13 Gene

NUDT13 (Nudix Hydrolase 13) is a Protein Coding gene. Among its related pathways are Purine metabolism (REACTOME) and Metabolism. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is NUDT12.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT13 Gene

Genomics for NUDT13 Gene

Regulatory Elements for NUDT13 Gene

Enhancers for NUDT13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G073261 1.9 FANTOM5 Ensembl ENCODE dbSUPER 33.1 +152.1 152059 2.7 FOXA2 PKNOX1 ARNT SIN3A ARID4B FEZF1 ZNF2 YY1 ZNF766 FOS NUDT13 CFAP70 ENSG00000233144 RNU6-883P USP54 ENSG00000227540 GC10P073280
GH10G073588 1.9 FANTOM5 Ensembl ENCODE dbSUPER 26.8 +480.9 480937 5.9 PKNOX1 FOXA2 MLX ZFP64 ARID4B FEZF1 DMAP1 SLC30A9 ZNF766 FOS NUDT13 USP54 RNU6-883P SYNPO2L AP3M1 CAMK2G PPP3CB CFAP70 GC10P073587 GC10P073609
GH10G073093 1.4 ENCODE dbSUPER 34.3 -14.3 -14338 4.1 MLX CREB3L1 AGO1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NUDT13 ECD CFAP70 DUSP8P5 GLUD1P3 ZSWIM8 ENSG00000237768 P4HA1 GC10M073083 ENSG00000201047
GH10G073243 1.4 ENCODE dbSUPER 33.9 +135.9 135859 5.5 HDGF HNRNPUL1 PKNOX1 CREB3L1 ARNT AGO1 ZFP64 WRNIP1 ARID4B SIN3A NUDT13 CFAP70 ENSG00000233144 DNAJC9-AS1 PIR34636
GH10G073250 1.4 ENCODE dbSUPER 33.9 +142.0 141959 3.5 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 NUDT13 ECD AP3M1 CFAP70 ENSG00000242288 GLUD1P3 DUSP8P5 ZSWIM8 ENSG00000272140 BMS1P4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NUDT13 on UCSC Golden Path with GeneCards custom track

Promoters for NUDT13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000029799 426 1200 HDGF PKNOX1 CREB3L1 ARNT ZFP64 ARID4B SIN3A ZNF2 YY1 SLC30A9

Genomic Location for NUDT13 Gene

Chromosome:
10
Start:
73,110,375 bp from pter
End:
73,131,828 bp from pter
Size:
21,454 bases
Orientation:
Plus strand

Genomic View for NUDT13 Gene

Genes around NUDT13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDT13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDT13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT13 Gene

Proteins for NUDT13 Gene

  • Protein details for NUDT13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86X67-NUD13_HUMAN
    Recommended name:
    Nucleoside diphosphate-linked moiety X motif 13
    Protein Accession:
    Q86X67
    Secondary Accessions:
    • B4DV90
    • O95650
    • Q5SQM4
    • Q5SQM5
    • Q5SQM6
    • Q9Y3X2

    Protein attributes for NUDT13 Gene

    Size:
    352 amino acids
    Molecular mass:
    39688 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD00649.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for NUDT13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUDT13 Gene

Post-translational modifications for NUDT13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NUDT13 Gene

Domains & Families for NUDT13 Gene

Gene Families for NUDT13 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NUDT13: view

No data available for UniProtKB/Swiss-Prot for NUDT13 Gene

Function for NUDT13 Gene

Enzyme Numbers (IUBMB) for NUDT13 Gene

Gene Ontology (GO) - Molecular Function for NUDT13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016462 pyrophosphatase activity TAS --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NUDT13: view
genes like me logo Genes that share phenotypes with NUDT13: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NUDT13

CRISPR Products

miRNA for NUDT13 Gene

miRTarBase miRNAs that target NUDT13

Inhibitory RNA Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUDT13 Gene

Localization for NUDT13 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUDT13 gene
Compartment Confidence
mitochondrion 5
nucleus 4
peroxisome 1

Gene Ontology (GO) - Cellular Components for NUDT13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with NUDT13: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NUDT13 Gene

Pathways & Interactions for NUDT13 Gene

genes like me logo Genes that share pathways with NUDT13: view

Pathways by source for NUDT13 Gene

Gene Ontology (GO) - Biological Process for NUDT13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015949 nucleobase-containing small molecule interconversion TAS --
genes like me logo Genes that share ontologies with NUDT13: view

No data available for SIGNOR curated interactions for NUDT13 Gene

Drugs & Compounds for NUDT13 Gene

No Compound Related Data Available

Transcripts for NUDT13 Gene

Unigene Clusters for NUDT13 Gene

Nudix (nucleoside diphosphate linked moiety X)-type motif 13:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT13 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11
SP1: - - - - - - -
SP2: - -
SP3:
SP4: - - - -
SP5: -

Relevant External Links for NUDT13 Gene

GeneLoc Exon Structure for
NUDT13
ECgene alternative splicing isoforms for
NUDT13

Expression for NUDT13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUDT13 Gene

NURSA nuclear receptor signaling pathways regulating expression of NUDT13 Gene:

NUDT13

SOURCE GeneReport for Unigene cluster for NUDT13 Gene:

Hs.533657

mRNA Expression by UniProt/SwissProt for NUDT13 Gene:

Q86X67-NUD13_HUMAN
Tissue specificity: Highly expressed in metastasis-suppressed chromosome 6 melanoma hybrids.

Evidence on tissue expression from TISSUES for NUDT13 Gene

  • Intestine(4.1)
genes like me logo Genes that share expression patterns with NUDT13: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUDT13 Gene

Orthologs for NUDT13 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NUDT13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUDT13 34 35
  • 99.24 (n)
cow
(Bos Taurus)
Mammalia NUDT13 34 35
  • 89.2 (n)
dog
(Canis familiaris)
Mammalia NUDT13 34 35
  • 88.86 (n)
mouse
(Mus musculus)
Mammalia Nudt13 34 16 35
  • 82.67 (n)
rat
(Rattus norvegicus)
Mammalia Nudt13 34
  • 80.97 (n)
oppossum
(Monodelphis domestica)
Mammalia NUDT13 35
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 68 (a)
OneToMany
-- 35
  • 53 (a)
OneToMany
chicken
(Gallus gallus)
Aves NUDT13 34 35
  • 66.07 (n)
lizard
(Anolis carolinensis)
Reptilia NUDT13 35
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nudt13 34
  • 61.34 (n)
zebrafish
(Danio rerio)
Actinopterygii nudt13 34 35
  • 58.88 (n)
NUDT13 (2 of 2) 35
  • 55 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ndx-9 34 35
  • 47.69 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NPY1 35
  • 20 (a)
OneToMany
Species where no ortholog for NUDT13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUDT13 Gene

ENSEMBL:
Gene Tree for NUDT13 (if available)
TreeFam:
Gene Tree for NUDT13 (if available)

Paralogs for NUDT13 Gene

Paralogs for NUDT13 Gene

(1) SIMAP similar genes for NUDT13 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NUDT13: view

Variants for NUDT13 Gene

Sequence variations from dbSNP and Humsavar for NUDT13 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000134771 -- 73,110,118(+) TTTTA(A/G)AGCTA upstream-variant-2KB
rs1000240189 -- 73,116,308(+) CCAGC(C/T)TAAGA intron-variant
rs1000244191 -- 73,126,478(+) CCTAG(A/C)AGACT intron-variant
rs1000383926 -- 73,130,717(+) AACTT(A/G)AGAGA nc-transcript-variant, reference, synonymous-codon, utr-variant-3-prime
rs1000384922 -- 73,111,286(+) AAAAA(C/G)GTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUDT13 Gene

Variant ID Type Subtype PubMed ID
nsv1120224 CNV tandem duplication 24896259
nsv527219 CNV loss 19592680

Variation tolerance for NUDT13 Gene

Residual Variation Intolerance Score: 84.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.84; 67.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUDT13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUDT13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT13 Gene

Disorders for NUDT13 Gene

Relevant External Links for NUDT13

Genetic Association Database (GAD)
NUDT13
Human Genome Epidemiology (HuGE) Navigator
NUDT13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUDT13

No disorders were found for NUDT13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUDT13 Gene

Publications for NUDT13 Gene

  1. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 2 3 4 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for NUDT13 Gene

Sources for NUDT13 Gene

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