NUDT13 Gene
protein-coding GIFtS: 45
GCID: GC10P074870
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nudix (nucleoside diphosphate linked moiety X)-type motif...
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Aliases
for NUDT13 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 131 2 | | Nudix Motif 132 3 | | DKFZp586P22191 | | Nucleoside Diphosphate-Linked Moiety X Motif 132 | | EC 3.-.-.-3 | | Protein KiSS-163 |
Export aliases for NUDT13 gene to outside databasesPrevious GC identifers: GC10P073648 GC10M073973 GC10P074762 GC10P074214 GC10P074540 GC10P068863 |
Summaries
for NUDT13 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for NUDT13 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NUDT13 gene promoter:
Nkx3-1 RP58 MAZR Nkx3-1 v1 CUTL1 Tal-1beta E47 Nkx3-1 v2 HFH-1 Nkx3-1 v3
Other transcription factors
Search SABiosciences Chromatin IP Primers for NUDT13
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUDT13 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q22.1 Ensembl cytogenetic band: 10q22.1 HGNC cytogenetic band: 10q22.3NUDT13 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P074870: view genomic region
(about GC identifiers)
Start:
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74,870,210 bp from pter |
End:
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74,891,586 bp from pter |
Size:
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21,377 bases |
Orientation:
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plus strand |
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Proteins
for NUDT13 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NUD13_HUMAN, Q86X67 (See
protein sequence)Recommended Name: Nucleoside diphosphate-linked moiety X motif 13 Size: 352 amino acids; 39688 Da
Sequence caution: Sequence=AAD00649.1; Type=Frameshift; Positions=Several;
Secondary accessions: O95650 Q5SQM4 Q5SQM5 Q9Y3X2Alternative splicing: 2 isoforms: Q86X67-1 Q86X67-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for NUDT13: NX_Q86X67
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86X67
NUDT13 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_056985.3
ENSEMBL proteins: ENSP00000349874 ENSP00000335326 ENSP00000362088 ENSP00000440760 ENSP00000438223
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IEA | -- |
NUDT13 for ontologies About GeneDecksing
NUDT13 Antibody Products:
Assay Products for NUDT13: |
Protein
Domains /
Families
for NUDT13 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NUDT13 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86X67ProtoNet protein and cluster: Q86X67 1 Blocks protein family: IPB000086 NUDIX hydrolase
UniProtKB/Swiss-Prot: NUD13_HUMAN, Q86X67Similarity: Contains 1 nudix hydrolase domain |
Function
for NUDT13 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Enzyme Number (IUBMB): EC 3.-.-.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT13 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT13
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NUDT13 (NM_015901) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NUDT13 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUDT13 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT13 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016787 | hydrolase activity |
IEA | -- | | GO:0046872 | metal ion binding |
IEA | -- |
NUDT13 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for NUDT13:
|
Pathways & Interactions
for NUDT13 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NUDT13
|
Drugs & Compounds
for NUDT13 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NUDT13
Search CenterWatch for drugs/clinical trials and news about NUDT13 / NUD13
|
Transcripts
for NUDT13 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NUDT13 gene: NM_015901.4 Unigene Cluster for NUDT13: Nudix (nucleoside diphosphate linked moiety X)-type motif 13 Hs.533657 [show with all ESTs]Unigene Representative Sequence: BC0312247 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000488223(uc009xqw.3) ENST00000357321(uc001jtj.3 uc010qkc.2 uc010qkd.2 uc001jtk.3 uc010qke.2)
ENST00000349051(uc001jtl.3) ENST00000469925 ENST00000372997 ENST00000544879
ENST00000537969
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT13 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT13
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NUDT13 (NM_015901) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NUDT13 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUDT13 |
Additional cDNA sequence: AK300980.1 AK303235.1 AK309755.1 AK316538.1 AL050114.1 BC031224.1 BC038833.1 BC046173.2 9 DOTS entries: DT.101976714 DT.409888 DT.91676644 DT.100680906 DT.101975510 DT.121301491 DT.40130916 DT.91796278 DT.97799953 24/50 AceView cDNA sequences (see all 50): BF194939 AI241312 CR599355 CR619117 AL050114 BX097194 AI539543 AL577776 CB241477 AL555230 NM_015901 BC046173 BX390072 BE784307 W80642 BU632671 BC038833 AI949467 BC031224 AI474811 BF831629 BE894030 AA701591 AI701810
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for NUDT13 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 |
|---|
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| SP1: | | | - | | - | | - | | - | | - | | - | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NUDT13
|
Expression
for NUDT13 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NUDT13 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See NUDT13 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NUDT13
SOURCE GeneReport for Unigene cluster: Hs.533657
UniProtKB/Swiss-Prot: NUD13_HUMAN, Q86X67Tissue specificity: Highly expressed in metastasis-suppressed chromosome 6 melanoma hybrids
SABiosciences Expression via Pathway-Focused PCR Arrays including NUDT13: | Epithelial to Mesenchymal Transition (EMT) in human mouse rat | | Molecular Toxicology PathwayFinder 384HT in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUDT13
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NUDT13 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUDT13 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUDT13 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT13 |
Orthologs
for NUDT13 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for NUDT13 gene from 5/15 species (see all 15) About this table
ENSEMBL Gene Tree for NUDT13 (if available)
TreeFam Gene Tree for NUDT13 (if available) |
Paralogs
for NUDT13 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NUDT13 gene
- NUDT122
1 SIMAP similar gene for NUDT13 using alignment to 5 protein entries: NUD13_HUMAN (see all proteins):NUDT12
NUDT13 for paralogs About GeneDecksing
|
Genomic Variants
for NUDT13 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NUDT13 (74870210 - 74891586 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NUDT13: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NUDT13 |
|
Disorders
/ Diseases
for NUDT13 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NUDT13 for disorders About GeneDecksing
OMIM gene information: 609233
OMIM disorders: --
4  diseases for NUDT13: About MalaCardsalzheimer's disease tuberculosis melanoma mycobacterium tuberculosis
Human Genome Epidemiology (HuGE) Navigator: NUDT13 (2 documents)
Export disorders for NUDT13 gene to outside databases
|
Publications
for NUDT13 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NUDT13 gene integrated from 9 sources:
(articles sorted by number of sources associating them with NUDT13) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2, 3 Deloukas P.... Rogers J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Creation of genome-wide protein expression libraries using random activation of gene expression. (PubMed id 11329013)1 Harrington J.J.... Ducar M. (2001)
|
External Searches for NUDT13 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NUDT13 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NUDT13 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NUDT13 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NUDT13 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NUDT13 gene:
Search GeneIP for patents involving NUDT13
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NUDT13 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NUDT13 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NUDT13 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUDT13 | | | OriGene Protein Over-expression Lysate for NUDT13 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT13 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUDT13 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NUDT13 | | OriGene Custom Protein Services for NUDT13 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NUDT13 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NUDT13 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUDT13 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUDT13 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUDT13 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUDT13 |
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| | | | Search Tocris compounds for NUDT13 |
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 | | | NUDT13 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT13 |
|  |  |  | | | | Search ThermoFisher Antibodies for NUDT13 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUDT13 |
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