Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NUDT13 Gene

Aliases for NUDT13 Gene

  • Nudix Hydrolase 13 2 3 5
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 13 2
  • Protein KiSS-16 4
  • Nudix Motif 13 4
  • EC 3.-.-.- 4

External Ids for NUDT13 Gene

Previous GeneCards Identifiers for NUDT13 Gene

  • GC10P073648
  • GC10M073973
  • GC10P074762
  • GC10P074214
  • GC10P074540
  • GC10P074870
  • GC10P068863

Summaries for NUDT13 Gene

GeneCards Summary for NUDT13 Gene

NUDT13 (Nudix Hydrolase 13) is a Protein Coding gene. Among its related pathways are Metabolism and Purine metabolism (REACTOME). GO annotations related to this gene include hydrolase activity. An important paralog of this gene is NUDT12.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT13 Gene

Genomics for NUDT13 Gene

Regulatory Elements for NUDT13 Gene

Enhancers for NUDT13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F073261 1.6 FANTOM5 Ensembl ENCODE 33.1 +152.1 152059 2.7 PKNOX1 ATF1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF766 GATA2 FOS NUDT13 CFAP70 ENSG00000233144 RNU6-883P USP54 ENSG00000227540 GC10P073280
GH10F073250 1.2 ENCODE 41.8 +142.0 141959 3.5 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 NUDT13 AP3M1 CFAP70 RPL17P50 ECD ZSWIM8 DUSP8P5 BMS1P4 ENSG00000242288 GLUD1P3
GH10F073109 1.1 ENCODE 43.2 +0.7 683 2.4 HDGF PKNOX1 ARNT CREB3L1 ZFP64 SIN3A ARID4B ZNF2 YY1 SLC30A9 NUDT13 DUSP8P5 GLUD1P3 RPL17P50 DNAJC9 ANAPC16 ENSG00000242288 BMS1P4 ENSG00000272140 CFAP70
GH10F073588 1.7 FANTOM5 Ensembl ENCODE 26.9 +480.9 480937 5.9 PKNOX1 ATF1 MLX ZFP64 ARID4B FEZF1 DMAP1 ZNF48 ZNF121 SLC30A9 NUDT13 USP54 RPL17P50 GLUD1P3 DUSP8P5 RNU6-883P SYNPO2L ECD CAMK2G PPP3CB
GH10F073166 1.1 ENCODE 41.5 +57.6 57628 2.4 PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 NUDT13 RPL17P50 AP3M1 ECD DUSP8P5 GLUD1P3 ANAPC16 ZSWIM8 BMS1P4 ENSG00000242288
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NUDT13 on UCSC Golden Path with GeneCards custom track

Promoters for NUDT13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000221106 426 1200 HDGF ARNT CREB3L1 ZFP64 SIN3A ARID4B ZNF2 YY1 SLC30A9 ZNF143

Genomic Location for NUDT13 Gene

73,110,375 bp from pter
73,131,828 bp from pter
21,454 bases
Plus strand

Genomic View for NUDT13 Gene

Genes around NUDT13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDT13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDT13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT13 Gene

Proteins for NUDT13 Gene

  • Protein details for NUDT13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleoside diphosphate-linked moiety X motif 13
    Protein Accession:
    Secondary Accessions:
    • B4DV90
    • O95650
    • Q5SQM4
    • Q5SQM5
    • Q5SQM6
    • Q9Y3X2

    Protein attributes for NUDT13 Gene

    352 amino acids
    Molecular mass:
    39688 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD00649.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for NUDT13 Gene


neXtProt entry for NUDT13 Gene

Post-translational modifications for NUDT13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NUDT13 Gene

Domains & Families for NUDT13 Gene

Gene Families for NUDT13 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 nudix hydrolase domain.
  • Contains 1 nudix hydrolase domain.
genes like me logo Genes that share domains with NUDT13: view

Function for NUDT13 Gene

Enzyme Numbers (IUBMB) for NUDT13 Gene

Gene Ontology (GO) - Molecular Function for NUDT13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016462 pyrophosphatase activity TAS --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NUDT13: view
genes like me logo Genes that share phenotypes with NUDT13: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NUDT13

miRNA for NUDT13 Gene

miRTarBase miRNAs that target NUDT13

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUDT13 Gene

Localization for NUDT13 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUDT13 gene
Compartment Confidence
mitochondrion 5
nucleus 4
peroxisome 1

Gene Ontology (GO) - Cellular Components for NUDT13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with NUDT13: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NUDT13 Gene

Pathways & Interactions for NUDT13 Gene

genes like me logo Genes that share pathways with NUDT13: view

Pathways by source for NUDT13 Gene

Interacting Proteins for NUDT13 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000349874 Q86X67-NUD13_HUMAN for NUDT13 Gene via STRING IID

Gene Ontology (GO) - Biological Process for NUDT13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015949 nucleobase-containing small molecule interconversion TAS --
genes like me logo Genes that share ontologies with NUDT13: view

No data available for SIGNOR curated interactions for NUDT13 Gene

Transcripts for NUDT13 Gene

Unigene Clusters for NUDT13 Gene

Nudix (nucleoside diphosphate linked moiety X)-type motif 13:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT13 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11
SP1: - - - - - - -
SP2: - -
SP4: - - - -
SP5: -

Relevant External Links for NUDT13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NUDT13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NUDT13 Gene

NURSA nuclear receptor signaling pathways regulating expression of NUDT13 Gene:


SOURCE GeneReport for Unigene cluster for NUDT13 Gene:


mRNA Expression by UniProt/SwissProt for NUDT13 Gene:

Tissue specificity: Highly expressed in metastasis-suppressed chromosome 6 melanoma hybrids.
genes like me logo Genes that share expression patterns with NUDT13: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NUDT13 Gene

Orthologs for NUDT13 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NUDT13 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NUDT13 34 35
  • 99.24 (n)
(Bos Taurus)
Mammalia NUDT13 34 35
  • 89.2 (n)
(Canis familiaris)
Mammalia NUDT13 34 35
  • 88.86 (n)
(Mus musculus)
Mammalia Nudt13 34 16 35
  • 82.67 (n)
(Rattus norvegicus)
Mammalia Nudt13 34
  • 80.97 (n)
(Monodelphis domestica)
Mammalia NUDT13 35
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 68 (a)
-- 35
  • 53 (a)
(Gallus gallus)
Aves NUDT13 34 35
  • 66.07 (n)
(Anolis carolinensis)
Reptilia NUDT13 35
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nudt13 34
  • 61.34 (n)
(Danio rerio)
Actinopterygii nudt13 34 35
  • 58.88 (n)
NUDT13 (2 of 2) 35
  • 55 (a)
(Caenorhabditis elegans)
Secernentea ndx-9 34 35
  • 47.69 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NPY1 35
  • 20 (a)
Species where no ortholog for NUDT13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUDT13 Gene

Gene Tree for NUDT13 (if available)
Gene Tree for NUDT13 (if available)

Paralogs for NUDT13 Gene

Paralogs for NUDT13 Gene

(1) SIMAP similar genes for NUDT13 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NUDT13: view

Variants for NUDT13 Gene

Sequence variations from dbSNP and Humsavar for NUDT13 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs10539030 -- 73,130,462(+) CGTCT(-/AAA)AAAAA intron-variant
rs10563382 -- 73,109,113(+) AAAAA(-/AAA)GTGTC upstream-variant-2KB
rs10602463 -- 73,124,046(+) ATCCT(-/CCT)GCCTC intron-variant
rs11000521 -- 73,111,011(+) TCACT(C/T)GGTCG intron-variant
rs11000522 -- 73,111,095(+) CCTCA(G/T)ACTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUDT13 Gene

Variant ID Type Subtype PubMed ID
nsv527219 CNV loss 19592680
nsv1120224 CNV tandem duplication 24896259

Variation tolerance for NUDT13 Gene

Residual Variation Intolerance Score: 84.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.84; 67.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUDT13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT13 Gene

Disorders for NUDT13 Gene

Relevant External Links for NUDT13

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NUDT13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUDT13 Gene

Publications for NUDT13 Gene

  1. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 2 3 4 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for NUDT13 Gene

Sources for NUDT13 Gene

Loading form....