Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NUDT13 Gene

Aliases for NUDT13 Gene

  • Nudix Hydrolase 13 2 3 5
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 13 2
  • Protein KiSS-16 4
  • Nudix Motif 13 4
  • EC 3.-.-.- 4

External Ids for NUDT13 Gene

Previous GeneCards Identifiers for NUDT13 Gene

  • GC10P073648
  • GC10M073973
  • GC10P074762
  • GC10P074214
  • GC10P074540
  • GC10P074870
  • GC10P068863

Summaries for NUDT13 Gene

GeneCards Summary for NUDT13 Gene

NUDT13 (Nudix Hydrolase 13) is a Protein Coding gene. Among its related pathways are Metabolism and Purine metabolism. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is NUDT12.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT13 Gene

Genomics for NUDT13 Gene

Regulatory Elements for NUDT13 Gene

Promoters for NUDT13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NUDT13 on UCSC Golden Path with GeneCards custom track

Genomic Location for NUDT13 Gene

Chromosome:
10
Start:
73,110,375 bp from pter
End:
73,131,828 bp from pter
Size:
21,454 bases
Orientation:
Plus strand

Genomic View for NUDT13 Gene

Genes around NUDT13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDT13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDT13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT13 Gene

Proteins for NUDT13 Gene

  • Protein details for NUDT13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86X67-NUD13_HUMAN
    Recommended name:
    Nucleoside diphosphate-linked moiety X motif 13
    Protein Accession:
    Q86X67
    Secondary Accessions:
    • B4DV90
    • O95650
    • Q5SQM4
    • Q5SQM5
    • Q5SQM6
    • Q9Y3X2

    Protein attributes for NUDT13 Gene

    Size:
    352 amino acids
    Molecular mass:
    39688 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD00649.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for NUDT13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUDT13 Gene

Proteomics data for NUDT13 Gene at MOPED

Post-translational modifications for NUDT13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NUDT13 Gene

Domains & Families for NUDT13 Gene

Gene Families for NUDT13 Gene

Graphical View of Domain Structure for InterPro Entry

Q86X67

UniProtKB/Swiss-Prot:

NUD13_HUMAN :
  • Contains 1 nudix hydrolase domain.
Domain:
  • Contains 1 nudix hydrolase domain.
genes like me logo Genes that share domains with NUDT13: view

Function for NUDT13 Gene

Enzyme Numbers (IUBMB) for NUDT13 Gene

Gene Ontology (GO) - Molecular Function for NUDT13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with NUDT13: view
genes like me logo Genes that share phenotypes with NUDT13: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NUDT13

miRNA for NUDT13 Gene

miRTarBase miRNAs that target NUDT13

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUDT13 Gene

Localization for NUDT13 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUDT13 Gene COMPARTMENTS Subcellular localization image for NUDT13 gene
Compartment Confidence
nucleus 4
mitochondrion 3
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NUDT13 Gene

Pathways & Interactions for NUDT13 Gene

genes like me logo Genes that share pathways with NUDT13: view

Pathways by source for NUDT13 Gene

Interacting Proteins for NUDT13 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000349874%0d%0a9606.ENSP00000293406%0d%0a
Selected Interacting proteins: ENSP00000349874 for NUDT13 Gene via STRING

Symbol External ID(s) Details
LSM12

Gene Ontology (GO) - Biological Process for NUDT13 Gene

None

No data available for SIGNOR curated interactions for NUDT13 Gene

Drugs & Compounds for NUDT13 Gene

No Compound Related Data Available

Transcripts for NUDT13 Gene

Unigene Clusters for NUDT13 Gene

Nudix (nucleoside diphosphate linked moiety X)-type motif 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT13 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11
SP1: - - - - - - -
SP2: - -
SP3:
SP4: - - - -
SP5: -

Relevant External Links for NUDT13 Gene

GeneLoc Exon Structure for
NUDT13
ECgene alternative splicing isoforms for
NUDT13

Expression for NUDT13 Gene

mRNA expression in normal human tissues for NUDT13 Gene

SOURCE GeneReport for Unigene cluster for NUDT13 Gene Hs.533657

mRNA Expression by UniProt/SwissProt for NUDT13 Gene

Q86X67-NUD13_HUMAN
Tissue specificity: Highly expressed in metastasis-suppressed chromosome 6 melanoma hybrids.
genes like me logo Genes that share expression patterns with NUDT13: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NUDT13 Gene

Orthologs for NUDT13 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NUDT13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUDT13 35
  • 99.24 (n)
  • 99.15 (a)
NUDT13 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NUDT13 36
  • 85 (a)
OneToOne
NUDT13 35
  • 89.2 (n)
  • 84.66 (a)
dog
(Canis familiaris)
Mammalia NUDT13 35
  • 88.86 (n)
  • 85.71 (a)
NUDT13 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nudt13 16
Nudt13 36
  • 78 (a)
OneToOne
Nudt13 35
  • 82.67 (n)
  • 77.84 (a)
oppossum
(Monodelphis domestica)
Mammalia NUDT13 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 68 (a)
OneToMany
-- 36
  • 53 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nudt13 35
  • 80.97 (n)
  • 77.84 (a)
chicken
(Gallus gallus)
Aves NUDT13 36
  • 61 (a)
OneToOne
NUDT13 35
  • 66.07 (n)
  • 62.43 (a)
lizard
(Anolis carolinensis)
Reptilia NUDT13 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nudt13 35
  • 61.34 (n)
  • 58.31 (a)
zebrafish
(Danio rerio)
Actinopterygii nudt13 36
  • 48 (a)
OneToMany
NUDT13 (2 of 2) 36
  • 55 (a)
OneToMany
nudt13 35
  • 58.88 (n)
  • 53.64 (a)
worm
(Caenorhabditis elegans)
Secernentea ndx-9 35
  • 47.69 (n)
  • 38.89 (a)
ndx-9 36
  • 27 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NPY1 36
  • 20 (a)
OneToMany
Species with no ortholog for NUDT13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUDT13 Gene

ENSEMBL:
Gene Tree for NUDT13 (if available)
TreeFam:
Gene Tree for NUDT13 (if available)

Paralogs for NUDT13 Gene

Paralogs for NUDT13 Gene

(1) SIMAP similar genes for NUDT13 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NUDT13: view

Variants for NUDT13 Gene

Sequence variations from dbSNP and Humsavar for NUDT13 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs34284214 - 73,122,193(+) CCTGG(A/G)TAAAT nc-transcript-variant, reference, missense, utr-variant-5-prime
rs17658872 - 73,126,786(+) CACTC(A/G)TGATT intron-variant, nc-transcript-variant, downstream-variant-500B, reference, synonymous-codon, missense
rs872457 -- 73,110,033(-) GGATT(C/T)ATTTC upstream-variant-2KB
rs2394916 -- 73,115,455(-) GACTT(A/G)CGCCT intron-variant
rs2394917 -- 73,114,917(-) GATTT(A/C)ATAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUDT13 Gene

Variant ID Type Subtype PubMed ID
nsv895724 CNV Gain 21882294
nsv895725 CNV Loss 21882294
nsv527219 CNV Loss 19592680

Variation tolerance for NUDT13 Gene

Residual Variation Intolerance Score: 84.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.84; 67.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUDT13 Gene

HapMap Linkage Disequilibrium report
NUDT13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT13 Gene

Disorders for NUDT13 Gene

Relevant External Links for NUDT13

Genetic Association Database (GAD)
NUDT13
Human Genome Epidemiology (HuGE) Navigator
NUDT13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUDT13

No disorders were found for NUDT13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUDT13 Gene

Publications for NUDT13 Gene

  1. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for NUDT13 Gene

Sources for NUDT13 Gene

Back to Top

Content