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NUDT12 Gene

protein-coding   GIFtS: 60
GCID: GC05M102884

Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 121 2
Nucleoside Diphosphate Linked Moiety X-Type Motif 121 2
Nucleoside Diphosphate-Linked Moiety X Motif 122 3
Nudix Motif 122 3
EC 3.6.1.223 8
Peroxisomal NADH Pyrophosphatase NUDT122

External Ids:    HGNC: 188261   Entrez Gene: 835942   Ensembl: ENSG000001128747   OMIM: 6092325   UniProtKB: Q9BQG23   

Export aliases for NUDT12 gene to outside databases

Previous GC identifers: GC05M102544 GC05M103315 GC05M102915 GC05M102960 GC05M102912 GC05M098066


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NUDT12 Gene:
Nucleotides are involved in numerous biochemical reactions and pathways within the cell as substrates, cofactors,
and effectors. Nudix hydrolases, such as NUDT12, regulate the concentrations of individual nucleotides and of
nucleotide ratios in response to changing circumstances (Abdelraheim et al., 2003 (PubMed 12790796)).(supplied by
OMIM, Mar 2008)

GeneCards Summary for NUDT12 Gene:
NUDT12 (nudix (nucleoside diphosphate linked moiety X)-type motif 12) is a protein-coding gene. GO annotations related to this gene include NAD+ diphosphatase activity and NADH pyrophosphatase activity. An important paralog of this gene is NUDT13.

UniProtKB/Swiss-Prot: NUD12_HUMAN, Q9BQG2
Function: Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity
towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal
nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle

Gene Wiki entry for NUDT12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NUDT12 gene promoter:
         TBP   Bach2   POU6F1 (c2)   LCR-F1   Cdc5   PPAR-gamma1   FOXC1   NRF-2   POU2F1c   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNUDT12 promoter sequence
   Search Chromatin IP Primers for NUDT12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NUDT12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q21.2   Ensembl cytogenetic band:  5q21.2   HGNC cytogenetic band: 5q15

NUDT12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUDT12 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M102884:  view genomic region     (about GC identifiers)

Start:
102,884,556 bp from pter      End:
102,898,494 bp from pter
Size:
13,939 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NUD12_HUMAN, Q9BQG2 (See protein sequence)
Recommended Name: Peroxisomal NADH pyrophosphatase NUDT12  
Size: 462 amino acids; 52076 Da
Cofactor: Magnesium or manganese (By similarity)
Secondary accessions: B3KUW2 Q8TAL7

Explore the universe of human proteins at neXtProt for NUDT12: NX_Q9BQG2

Explore proteomics data for NUDT12 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for NUDT12 (Q9BQG2) (see all 18)
     ECENYFS  EEEDGLV  DKNEIED  KRNNSDWL 


    See NUDT12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_113626.1  
    ENSEMBL proteins: 
     ENSP00000230792   ENSP00000424521  

    NUDT12 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for NUDT12

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing
    NUDT: Nudix motif containing

    Selected InterPro protein domains (see all 7):
     IPR015797 NUDIX_hydrolase_dom-like
     IPR002110 Ankyrin_rpt
     IPR015376 Znr_NADH_PPase
     IPR020084 NUDIX_hydrolase_CS
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q9BQG2

    ProtoNet protein and cluster: Q9BQG2

    2 Blocks protein domains:
    IPB000086 NUDIX hydrolase
    IPB002110 Ankyrin repeat signature


    UniProtKB/Swiss-Prot: NUD12_HUMAN, Q9BQG2
    Similarity: Belongs to the Nudix hydrolase family. NudC subfamily
    Similarity: Contains 3 ANK repeats
    Similarity: Contains 1 nudix hydrolase domain


    Find genes that share domains with NUDT12           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NUD12_HUMAN, Q9BQG2
    Function: Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity
    towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal
    nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle
    Catalytic activity: NAD(+) + H(2)O = AMP + NMN
    Biophysicochemical properties: Kinetic parameters: KM=11 uM for NADH; KM=16 uM for NADPH; KM=190 uM for NAD; pH
    dependence: Optimum pH is 8-9;

         Enzyme Number (IUBMB): EC 3.6.1.221 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000210NAD+ diphosphatase activity IDA12790796
    GO:0005515protein binding ----
    GO:0016787hydrolase activity ----
    GO:0035529NADH pyrophosphatase activity IDA12790796
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with NUDT12           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Nudt12 (no phenotypes)

    Find genes that share phenotypes with NUDT12           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NUDT12
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NUDT12

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NUDT12
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NUDT12

    miRNA
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    miRTarBase miRNAs that target NUDT12:
    hsa-mir-181a-5p (MIRT025180)

    Block miRNA regulation of human, mouse, rat NUDT12 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NUDT12 (see all 21):
    hsa-miR-411* hsa-miR-607 hsa-miR-379* hsa-miR-181c hsa-miR-548a-3p hsa-miR-205* hsa-miR-181b hsa-miR-4257
    SwitchGear 3'UTR luciferase reporter plasmidNUDT12 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NUDT12

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: NUDT12 (NM_031438)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT12


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NUD12_HUMAN, Q9BQG2: Peroxisome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    peroxisome5
    nucleus4

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm ----
    GO:0005777peroxisome IDA12790796

    Find genes that share ontologies with NUDT12           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NUDT12 About    
    See pathways by source

    SuperPathContained pathways About
    1Nicotinate and nicotinamide metabolism
    Nicotinate and nicotinamide metabolism0.43
    NAD metabolism0.43
    2Peroxisome
    Peroxisome


    Find genes that share SuperPaths with NUDT12           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for NUDT12
        NAD metabolism


    2 Kegg Pathways  (Kegg details for NUDT12):
        Nicotinate and nicotinamide metabolism
    Peroxisome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NUDT12
    Interactions:

        Search GeneGlobe Interaction Network for NUDT12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NUDT12 (Q9BQG23 ENSP000002307924) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CETN3O151823, ENSP000002831224I2D: score=3 STRING: ENSP00000283122
    ACOT8O147343I2D: score=1 
    DNAJA1P316893I2D: score=1 
    H2AFZP0C0S53I2D: score=1 
    IP6K3Q96PC23I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006742NADP catabolic process IDA12790796
    GO:0019677NAD catabolic process IDA12790796

    Find genes that share ontologies with NUDT12           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NUDT12 (NUD12)

    9 HMDB Compounds for NUDT12    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    Nicotinamide ribotide3-(aminocarbonyl)-1-(5-O-phosphono-b-D-ribofuranosyl)-Pyridinium hydroxide inner salt (see all 15)1094-61-7--
    Nicotinic acid adenine dinucleotideNAAD (see all 9)6450-77-7--
    Nicotinic acid mononucleotide3-Carboxy-1-beta-D-ribofuranosylpyridinium hydroxide 5'-phosphate inner salt (see all 23)321-02-8--
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NUDT12 gene: 
    NM_031438.2  

    Unigene Cluster for NUDT12:

    Nudix (nucleoside diphosphate linked moiety X)-type motif 12
    Hs.434289  [show with all ESTs]
    Unigene Representative Sequence: NM_031438
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000230792(uc003koi.3 uc011cvb.2) ENST00000507423 ENST00000515407
    ENST00000508889(uc010jbq.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat NUDT12 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NUDT12 (see all 21):
    hsa-miR-411* hsa-miR-607 hsa-miR-379* hsa-miR-181c hsa-miR-548a-3p hsa-miR-205* hsa-miR-181b hsa-miR-4257
    SwitchGear 3'UTR luciferase reporter plasmidNUDT12 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: NUDT12 (NM_031438)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NUDT12
      QuantiTect SYBR Green Assays in human, mouse, rat NUDT12
      QuantiFast Probe-based Assays in human, mouse, rat NUDT12

    Additional mRNA sequence: 

    AK098066.1 AK304010.1 AK309942.1 AL136592.1 BC026748.1 BC041099.1 

    4 DOTS entries:

    DT.70104078  DT.423151  DT.91837033  DT.95303722 

    Selected AceView cDNA sequences (see all 61):

    BC026748 NM_031438 CB131118 CA411882 BX281841 AI207545 BF513640 BC041099 
    BI850602 BF940298 BU679099 BP370190 AW361036 AK098066 AV706816 BG400646 
    BQ428185 AI635320 BG545936 BF033178 AI520819 BC042967 BI560422 BP369892 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NUDT12 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8
    SP1:              -                       -     -                                         -               
    SP2:              -                       -     -                                                         
    SP3:              -                 -     -     -                                                         
    SP4:              -                                                                                       
    SP5:              -                                                                                       


    ECgene alternative splicing isoforms for NUDT12

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NUDT12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGGAGAAA
    NUDT12 Expression
    About this image

    NUDT12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NUDT12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.434289
        Custom PCR Arrays for NUDT12
    Primer
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    OriGene qPCR primer pairs and template standards for NUDT12
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    QuantiFast Probe-based Assays in human, mouse, rat NUDT12
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NUDT12 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nudt121 , 5 nudix (nucleoside diphosphate linked moiety X)-type more1, 5 84.13(n)1
    87.88(a)1
      17 (30.64 cM)5
    679931  NM_026497.21  NP_080773.11 
     589996185 
    chicken
    (Gallus gallus)
    Aves NUDT121 nudix (nucleoside diphosphate linked moiety X)-type more 75.9(n)
    75.54(a)
      768471  XM_004949297.1  XP_004949354.1 
    lizard
    (Anolis carolinensis)
    Reptilia NUDT126
    nudix (nucleoside diphosphate linked moiety X)-typ...
    65(a)
    1 ↔ 1
    GL343193.1(1974189-1996092)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ084371.12   -- 79.47(n)    BJ084371.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BI878334.12   -- 72.92(n)    BI878334.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NPY1(YGL067W)4
    NPY11
    NADH diphosphatase (pyrophosphatase), hydrolyzes the more4
    NPY11
    46.12(n)1
    33.53(a)1
      7(376101-377255)4
    8528131, 4  NP_011448.31  NP_011448.14 
    soybean
    (Glycine max)
    eudicotyledons Gma.17332 Transcribed sequence with moderate similarity to protein more 71.49(n)  


    ENSEMBL Gene Tree for NUDT12 (if available)
    TreeFam Gene Tree for NUDT12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NUDT12 gene
    NUDT132  
    1 SIMAP similar gene for NUDT12 using alignment to 2 protein entries:     NUD12_HUMAN (see all proteins):
    NUDT13

    Find genes that share paralogs with NUDT12           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NUDT12 (see all 366)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1864731871,2
    --102884061(+) TGTTAA/TGTGGG 1 -- int10--------
    rs1156232451,2
    C--102884128(+) TTGTTA/TTCCTA 1 -- int10--------
    rs1827191451,2
    --102884165(+) TAACTA/GGGTCT 1 -- int10--------
    rs1850652461,2
    --102884209(+) AATATA/GTGGGC 1 -- int10--------
    rs1909016371,2
    --102884306(+) TCGCTG/TTAAAC 1 -- int10--------
    rs1510743131,2
    --102884344(+) ATATGC/TATGTA 1 -- int10--------
    rs1409894661,2
    --102884392(+) CTTTAA/TGATTC 1 -- int10--------
    rs1698001,2
    C,F--102884487(+) AACGAT/CTGAAA 1 -- int110Minor allele frequency- C:0.27NA WA CSA EA 370
    rs1499398291,2
    C--102884578(+) ATGTAG/TTATTA 1 -- ut310--------
    rs1830911381,2
    --102884598(+) CCAGTA/GGAATA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NUDT12 (102884556 - 102898494 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NUDT12:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv882523CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NUDT12
    DNA2.0 Custom Variant and Variant Library Synthesis for NUDT12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609232    OMIM disorders: --


    Find genes that share disorders with NUDT12           About GenesLikeMe

    Genetic Association Database (GAD): NUDT12
    Human Genome Epidemiology (HuGE) Navigator: NUDT12 (2 documents)

    Export disorders for NUDT12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NUDT12 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with NUDT12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Mammalian NADH diphosphatases of the Nudix family: cloning and characterization of the human peroxisomal NUDT12 protein. (PubMed id 12790796)1, 2 Abdelraheim S.R.... McLennan A.G. (Biochem. J. 2003)
    6. Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. (PubMed id 23400010)1 Del-Aguila J.L....Boerwinkle E. (Pharmacogenomics J. 2013)
    7. A genome-wide association study of depressive symptoms. (PubMed id 23290196)1 Hek K....Murabito J. (Biol. Psychiatry 2013)
    8. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (BMC Med. Genet. 2007)
    9. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)4 Benjamin E.J....Vasan R.S. (BMC Med. Genet. 2007)
    10. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296)4 Kiel D.P....Karasik D. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 83594 HGNC: 18826 AceView: NUDT12 Ensembl:ENSG00000112874 euGenes: HUgn83594
    ECgene: NUDT12 Kegg: 83594 H-InvDB: NUDT12

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NUDT12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NUDT12 gene:
    Search GeneIP for patents involving NUDT12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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