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NUDT11 Gene

protein-coding   GIFtS: 56
GCID: GC0XM051232

Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 111 2     hDIPP3beta2 3
APS12 3 5     DIPP3B3 5
Diadenosine 5',5'''-P1,P6-Hexaphosphate Hydrolase 3-Beta2 3     ASP12
Diadenosine Hexaphosphate Hydrolase (AMP-Forming)2 3     DIPP3b2
Nucleoside Diphosphate-Linked Moiety X Motif 112 3     DIPP3beta2
Nudix Motif 112 3     Diphosphoinositol Polyphosphate Phosphohydrolase 3, Beta2
DIPP-3-beta2 3     Diphosphoinositol Polyphosphate Phosphohydrolase 3-Beta2
DIPP3-beta2 3     EC 3.6.1.523
hAps12 3     EC 3.6.1.603

External Ids:    HGNC: 180111   Entrez Gene: 551902   Ensembl: ENSG000001963687   OMIM: 3005285   UniProtKB: Q96G613   

Export aliases for NUDT11 gene to outside databases

Previous GC identifers: GC0XP049645 GC0XM049277 GC0XM049917 GC0XM050149 GC0XM051065 GC0XM051249 GC0XM048674


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NUDT11 Gene:
NUDT11 belongs to a subgroup of phosphohydrolases that preferentially attack diphosphoinositol polyphosphates
(Hidaka et al., 2002 (PubMed 12105228)).(supplied by OMIM, Mar 2008)

GeneCards Summary for NUDT11 Gene:
NUDT11 (nudix (nucleoside diphosphate linked moiety X)-type motif 11) is a protein-coding gene. Diseases associated with NUDT11 include prostate cancer, and prostatitis. GO annotations related to this gene include inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity and diphosphoinositol-polyphosphate diphosphatase activity. An important paralog of this gene is NUDT4.

UniProtKB/Swiss-Prot: NUD11_HUMAN, Q96G61
Function: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate),
suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside
oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a
from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate

Gene Wiki entry for NUDT11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_011630.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the NUDT11 gene promoter:
         Elk-1   Spz1   Bach2   FOXD3   HSF1 (long)   FOXD1   S8   HSF1short   c-Myb   Ik-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for NUDT11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NUDT11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.22   Ensembl cytogenetic band:  Xp11.22   HGNC cytogenetic band: Xp11.22-p11.1

NUDT11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUDT11 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM051232:  view genomic region     (about GC identifiers)

Start:
51,232,863 bp from pter      End:
51,239,459 bp from pter
Size:
6,597 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NUD11_HUMAN, Q96G61 (See protein sequence)
Recommended Name: Diphosphoinositol polyphosphate phosphohydrolase 3-beta  
Size: 164 amino acids; 18559 Da
Cofactor: Binds 3 magnesium or manganese ions per subunit (By similarity). Manganese may be the true cofactor in
vivo
Secondary accessions: Q9NVN0

Explore the universe of human proteins at neXtProt for NUDT11: NX_Q96G61

Explore proteomics data for NUDT11 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NUDT11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060629.2  
    ENSEMBL proteins: 
     ENSP00000365160  
    Reactome Protein details: Q96G61

    NUDT11 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NUDT: Nudix motif containing

    3 InterPro protein domains:
     IPR015797 NUDIX_hydrolase_dom-like
     IPR020084 NUDIX_hydrolase_CS
     IPR000086 NUDIX_hydrolase_dom

    Graphical View of Domain Structure for InterPro Entry Q96G61

    ProtoNet protein and cluster: Q96G61

    1 Blocks protein domain: IPB000086 NUDIX hydrolase

    UniProtKB/Swiss-Prot: NUD11_HUMAN, Q96G61
    Similarity: Belongs to the Nudix hydrolase family. DIPP subfamily
    Similarity: Contains 1 nudix hydrolase domain


    NUDT11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NUD11_HUMAN, Q96G61
    Function: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate),
    suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside
    oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a
    from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate
    Catalytic activity: Diphospho-myo-inositol polyphosphate + H(2)O = myo-inositol polyphosphate + phosphate
    Catalytic activity: P(1),P(6)-bis(5'-adenosyl)hexaphosphate + H(2)O = adenosine 5'-pentaphosphate + AMP
    Catalytic activity: P(1),P(5)-bis(5'-adenosyl)pentaphosphate + H(2)O = adenosine 5'-tetraphosphate + AMP
    Biophysicochemical properties: Kinetic parameters: KM=0.053 uM for PP-InsP5; KM=13 uM for Ap6A; KM=37 uM for Ap5A;
    pH dependence: Optimum pH is 8.5;

         Enzyme Numbers (IUBMB): EC 3.6.1.601 EC 3.6.1.521

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008486diphosphoinositol-polyphosphate diphosphatase activity ISS--
    GO:0016787hydrolase activity ----
    GO:0046872metal ion binding IEA--
    GO:0052840inositol diphosphate tetrakisphosphate diphosphatase activity IEA--
    GO:0052843inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity IEA--
         
    NUDT11 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NUDT11:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NUDT11
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    miRNA
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    miRTarBase miRNAs that target NUDT11:
    hsa-mir-30c-5p (MIRT048002)

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    Selected qRT-PCR Assays for microRNAs that regulate NUDT11 (see all 43):
    hsa-miR-607 hsa-miR-3607-3p hsa-miR-19b-2* hsa-miR-29a hsa-miR-548l hsa-miR-183* hsa-miR-3613-3p hsa-miR-3909
    SwitchGear 3'UTR luciferase reporter plasmidNUDT11 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NUD11_HUMAN, Q96G61: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005829cytosol TAS--

    NUDT11 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NUDT11 About    
    See pathways by source

    SuperPathContained pathways About
    1Inositol phosphate metabolism (REACTOME)
    Inositol phosphate metabolism0.59
    Synthesis of pyrophosphates in the cytosol0.00
    2Metabolism
    Metabolism0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for NUDT11
        Synthesis of pyrophosphates in the cytosol



    NUDT11 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NUDT11
    Interactions:

        Search GeneGlobe Interaction Network for NUDT11

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for NUDT11 (Q96G613 ENSP000003651604) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RASSF1Q9NS233I2D: score=1 
    TRAF6Q9Y4K33I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    --ENSP000003168404STRING: ENSP00000316840
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0043647inositol phosphate metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    NUDT11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for NUDT11 (NUD11)

    7 HMDB Compounds for NUDT11    About this table
    CompoundSynonyms CAS #PubMed Ids
    5-Diphosphoinositol pentakisphosphate5-diphospho-1D-myo-inositol pentakisphosphate (see all 11)----
    Diadenosine hexaphosphateAdenosine 5'-(heptahydrogen hexaphosphate) P->5'-ester with adenosine (see all 9)56983-23-4--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--
    Myo-inositol hexakisphosphate1D-myo-Inositol 1,2,3,4,5,6-hexakisphosphate (see all 9)83-86-3--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NUDT11 gene: 
    NM_018159.3  

    Unigene Cluster for NUDT11:

    Nudix (nucleoside diphosphate linked moiety X)-type motif 11
    Hs.200016  [show with all ESTs]
    Unigene Representative Sequence: NM_018159
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000375992(uc010njt.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat NUDT11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NUDT11 (see all 43):
    hsa-miR-607 hsa-miR-3607-3p hsa-miR-19b-2* hsa-miR-29a hsa-miR-548l hsa-miR-183* hsa-miR-3613-3p hsa-miR-3909
    SwitchGear 3'UTR luciferase reporter plasmidNUDT11 3' UTR sequence
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    Additional mRNA sequence: 

    AK001490.1 BC009942.2 

    4 DOTS entries:

    DT.310582  DT.100816953  DT.121319044  DT.95164464 

    Selected AceView cDNA sequences (see all 68):

    BG178019 R12527 NM_018159 BQ959454 F07882 BI546747 AW665496 BE046911 
    BU623271 BQ086279 CK822952 BQ218489 BC009942 AI014587 Z45045 AI928582 
    CK822951 AI246497 F07881 BX353795 BI602649 AL558242 AU280300 AA992099 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NUDT11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATACCAGTGA
    NUDT11 Expression
    About this image


    NUDT11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Presumptive Podocytes Podocyte Layer
             Metanephros
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     Testis (Reproductive System)
    NUDT11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NUDT11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.200016

    UniProtKB/Swiss-Prot: NUD11_HUMAN, Q96G61
    Tissue specificity: Mainly expressed in testis and, at lower level in brain. According to PubMed:12121577, it is
    also expressed in pancreas and weakly expressed in thymus, prostate, ovary, lung, small intestine and heart

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NUDT11 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nudt111 , 5 nudix (nucleoside diphosphate linked moiety X)-type more1, 5 88.01(n)1
    95.73(a)1
      X (2.68 cM)5
    582421  NM_021431.21  NP_067406.21 
     60474535 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    75(a)
    1 → many
    1(44690009-44710912)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    82(a)
    1 → many
    5(31478850-31494149)
    zebrafish
    (Danio rerio)
    Actinopterygii nudt4b6
    nudt4a6
    nudix (nucleoside diphosphate linked moiety X)-typ...
    nudix (nucleoside diphosphate linked moiety X)-typ...
    73(a)
    58(a)
    many ↔ many
    many ↔ many
    4(1648879-1662251) ENSDARG00000045878
    18(15474824-15516418) ENSDARG00000057767
    fruit fly
    (Drosophila melanogaster)
    Insecta Aps6
    Aps
    52(a)
    1 → many
    3L(10887876-10892223)
    worm
    (Caenorhabditis elegans)
    Secernentea Y92H12BL.56
    Protein Y92H12BL.5 (Y92H12BL.5) mRNA, complete cds...
    38(a)
    1 → many
    I(1365309-1375883) WBGene00022366


    ENSEMBL Gene Tree for NUDT11 (if available)
    TreeFam Gene Tree for NUDT11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NUDT11 gene
    NUDT42  NUDT32  NUDT102  
    4 SIMAP similar genes for NUDT11 using alignment to 1 protein entry:     NUD11_HUMAN:
    NUDT10    NUDT4    NUDT3    RPS10-NUDT3

    NUDT11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NUDT11 (see all 99)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1913325751,2
    --51232366(+) TTACAC/TGCAAT 1 -- int10--------
    rs1999842051,2
    C--51232385(+) ACTTT-/TAGTCAT 1 -- int10--------
    rs1835242651,2
    --51232439(+) GTGCTA/GTCAAA 1 -- int10--------
    rs1885056381,2
    --51232564(+) GGTAAA/TTAGTA 1 -- int10--------
    rs1116043551,2
    C,F--51232608(+) TCCACT/CACTAG 1 -- int11Minor allele frequency- C:0.00CSA 1
    rs2011676781,2
    --51232653(+) AAGGG-/GATAAAG 1 -- int10--------
    rs2003092101,2
    --51232656(+) GGGAT-/AAAGTC 1 -- int10--------
    rs1510991421,2
    C--51232709(+) ACTAAC/TGGAAG 1 -- int10--------
    rs1410339941,2
    --51232784(+) TTTCTA/GGGCTG 1 -- int10--------
    rs1919782131,2
    --51233103(+) TTAAAA/CCAACA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NUDT11 (51232863 - 51239459 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NUDT11:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv524351CNV Gain19592680
    nsv471604CNV Gain15918152

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NUDT11
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300528    OMIM disorders: --

    2 diseases for NUDT11:    
    About MalaCards
    prostate cancer    prostatitis


    NUDT11 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NUDT11
    Human Genome Epidemiology (HuGE) Navigator: NUDT11 (7 documents)

    Export disorders for NUDT11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NUDT11 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with NUDT11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase. (PubMed id 12105228)1, 2, 3, 9 Hidaka K.... Shears S.B. (J. Biol. Chem. 2002)
    2. Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases. (PubMed id 12121577)1, 2, 9 Leslie N.R.... Safrany S.T. (BMC Biochem. 2002)
    3. Replication of prostate cancer risk loci on 8q24, 11q13, 17q12, 19q33, and Xp11 in African Americans. (PubMed id 19902474)1, 4 Hooker S....Kittles R.A. (Prostate 2010)
    4. Multiple newly identified loci associated with prostate cancer susceptibility. (PubMed id 18264097)1, 4 Eeles R.A.... Easton D.F. (Nat. Genet. 2008)
    5. Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. (PubMed id 18264098)1, 4 Gudmundsson J.... Stefansson K. (Nat. Genet. 2008)
    6. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate. (PubMed id 12370170)1, 2 Fisher D.I.... Cartwright J.L. (J. Biol. Chem. 2002)
    10. Genetic and functional analyses implicate the NUDT11, HNF1B, and SLC22A3 genes in prostate cancer pathogenesis. (PubMed id 22730461)1 Grisanzio C....Freedman M.L. (Proc. Natl. Acad. Sci. U.S.A. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55190 HGNC: 18011 AceView: NUDT11 Ensembl:ENSG00000196368 euGenes: HUgn55190
    ECgene: NUDT11 H-InvDB: NUDT11

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NUDT11 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NUDT11 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NUDT11 gene:
    Search GeneIP for patents involving NUDT11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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