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Aliases for NUDT11 Gene

Aliases for NUDT11 Gene

  • Nudix Hydrolase 11 2 3 5
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 11 2 3
  • Diadenosine 5,5-P1,P6-Hexaphosphate Hydrolase 3-Beta 3 4
  • Diadenosine Hexaphosphate Hydrolase (AMP-Forming) 3 4
  • Nucleoside Diphosphate-Linked Moiety X Motif 11 3 4
  • Nudix Motif 11 3 4
  • DIPP-3-Beta 3 4
  • DIPP3-Beta 3 4
  • HDIPP3beta 3 4
  • DIPP3b 3 4
  • HAps1 3 4
  • APS1 3 4
  • Diphosphoinositol Polyphosphate Phosphohydrolase 3, Beta 3
  • Diphosphoinositol Polyphosphate Phosphohydrolase 3-Beta 3
  • EC 3.6.1.52 4
  • EC 3.6.1.60 4
  • DIPP3beta 3
  • ASP1 3

External Ids for NUDT11 Gene

Previous GeneCards Identifiers for NUDT11 Gene

  • GC0XP049645
  • GC0XM049277
  • GC0XM049917
  • GC0XM050149
  • GC0XM051065
  • GC0XM051249
  • GC0XM051232
  • GC0XM048674

Summaries for NUDT11 Gene

Entrez Gene Summary for NUDT11 Gene

  • NUDT11 belongs to a subgroup of phosphohydrolases that preferentially attack diphosphoinositol polyphosphates (Hidaka et al., 2002 [PubMed 12105228]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NUDT11 Gene

NUDT11 (Nudix Hydrolase 11) is a Protein Coding gene. Among its related pathways are Metabolism and Inositol phosphate metabolism (REACTOME). GO annotations related to this gene include hydrolase activity and inositol diphosphate tetrakisphosphate diphosphatase activity. An important paralog of this gene is NUDT10.

UniProtKB/Swiss-Prot for NUDT11 Gene

  • Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.

Gene Wiki entry for NUDT11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT11 Gene

Genomics for NUDT11 Gene

Regulatory Elements for NUDT11 Gene

Enhancers for NUDT11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF051456 0.2 ENCODE 20.1 +40.0 39976 0.7 CTCF ZNF654 RAD21 NUDT11 CXorf67
GH0XF051495 0.8 ENCODE 9.8 +0.1 73 1.7 ZNF263 MAZ L3MBTL2 NRF1 BHLHE40 SP2 ZIC2 GLIS2 POLR2A PATZ1 NUDT11 CXorf67
GH0XF051742 0.7 ENCODE 7.4 -246.8 -246750 1.8 ETV1 ZBTB40 YY1 EGR1 POLR2A CBX5 PATZ1 SCRT2 ZSCAN29 EGR2 NUDT11 GSPT2 CENPVL1
GH0XF051802 0.5 ENCODE 7.4 -306.8 -306826 1.9 TBP CTCF ATF1 ESRRA RAD21 ZBTB40 ETS1 ZNF664 GLIS2 POLR2A RNU6-504P CENPVL1 NUDT11 MAGED1 LOC100631242
GH0XF052015 0.4 ENCODE 7.4 -519.3 -519270 0.8 RFX1 NUDT11 GC0XP052044 TPMTP3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NUDT11 on UCSC Golden Path with GeneCards custom track

Promoters for NUDT11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000160692 606 3199 CTCF ZIC2 GLIS2 POLR2A SCRT2 NFE2 ZNF263 MAZ ZNF680 L3MBTL2

Genomic Location for NUDT11 Gene

Chromosome:
X
Start:
51,490,011 bp from pter
End:
51,496,607 bp from pter
Size:
6,597 bases
Orientation:
Minus strand

Genomic View for NUDT11 Gene

Genes around NUDT11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDT11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDT11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT11 Gene

Proteins for NUDT11 Gene

  • Protein details for NUDT11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96G61-NUD11_HUMAN
    Recommended name:
    Diphosphoinositol polyphosphate phosphohydrolase 3-beta
    Protein Accession:
    Q96G61
    Secondary Accessions:
    • Q9NVN0

    Protein attributes for NUDT11 Gene

    Size:
    164 amino acids
    Molecular mass:
    18559 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

neXtProt entry for NUDT11 Gene

Post-translational modifications for NUDT11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUDT11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NUDT11 Gene

Domains & Families for NUDT11 Gene

Gene Families for NUDT11 Gene

Protein Domains for NUDT11 Gene

Suggested Antigen Peptide Sequences for NUDT11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96G61

UniProtKB/Swiss-Prot:

NUD11_HUMAN :
  • Contains 1 nudix hydrolase domain.
  • Belongs to the Nudix hydrolase family. DIPP subfamily.
Domain:
  • Contains 1 nudix hydrolase domain.
Family:
  • Belongs to the Nudix hydrolase family. DIPP subfamily.
genes like me logo Genes that share domains with NUDT11: view

Function for NUDT11 Gene

Molecular function for NUDT11 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.053 uM for PP-InsP5 {ECO:0000269 PubMed:12105228, ECO:0000269 PubMed:12121577}; KM=13 uM for Ap6A {ECO:0000269 PubMed:12105228, ECO:0000269 PubMed:12121577}; KM=37 uM for Ap5A {ECO:0000269 PubMed:12105228, ECO:0000269 PubMed:12121577}; pH dependence: Optimum pH is 8.5. {ECO:0000269 PubMed:12105228, ECO:0000269 PubMed:12121577};
UniProtKB/Swiss-Prot CatalyticActivity:
Diphospho-myo-inositol polyphosphate + H(2)O = myo-inositol polyphosphate + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
P(1),P(6)-bis(5-adenosyl)hexaphosphate + H(2)O = adenosine 5-pentaphosphate + AMP.
UniProtKB/Swiss-Prot CatalyticActivity:
P(1),P(5)-bis(5-adenosyl)pentaphosphate + H(2)O = adenosine 5-tetraphosphate + AMP.
UniProtKB/Swiss-Prot Function:
Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.

Enzyme Numbers (IUBMB) for NUDT11 Gene

Gene Ontology (GO) - Molecular Function for NUDT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000298 endopolyphosphatase activity IBA --
GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity ISS,IBA --
GO:0016787 hydrolase activity IEA --
GO:0034431 bis(5-adenosyl)-hexaphosphatase activity IBA --
GO:0034432 bis(5-adenosyl)-pentaphosphatase activity IBA --
genes like me logo Genes that share ontologies with NUDT11: view
genes like me logo Genes that share phenotypes with NUDT11: view

Animal Model Products

miRNA for NUDT11 Gene

miRTarBase miRNAs that target NUDT11

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUDT11 Gene

Localization for NUDT11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDT11 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUDT11 Gene COMPARTMENTS Subcellular localization image for NUDT11 gene
Compartment Confidence
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for NUDT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IEA,IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NUDT11: view

Pathways & Interactions for NUDT11 Gene

genes like me logo Genes that share pathways with NUDT11: view

Pathways by source for NUDT11 Gene

Interacting Proteins for NUDT11 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000365160%0d%0a9606.ENSP00000417401%0d%0a9606.ENSP00000280665%0d%0a9606.ENSP00000279068%0d%0a9606.ENSP00000413964%0d%0a9606.ENSP00000264018%0d%0a
Selected Interacting proteins: ENSP00000365160 Q96G61-NUD11_HUMAN for NUDT11 Gene via STRING IID

Gene Ontology (GO) - Biological Process for NUDT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043647 inositol phosphate metabolic process TAS --
GO:0071543 diphosphoinositol polyphosphate metabolic process IBA --
GO:1901907 diadenosine pentaphosphate catabolic process IBA --
GO:1901909 diadenosine hexaphosphate catabolic process IBA --
GO:1901911 adenosine 5-(hexahydrogen pentaphosphate) catabolic process IBA --
genes like me logo Genes that share ontologies with NUDT11: view

No data available for SIGNOR curated interactions for NUDT11 Gene

Drugs & Compounds for NUDT11 Gene

(5) Drugs for NUDT11 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Manganese Approved Nutra 34
Magnesium Nutra 0

(6) Additional Compounds for NUDT11 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5-Diphosphoinositol pentakisphosphate
  • 1,2,3,4,6-Pentakis-O-phosphono-1D-myo-inositol 5-(trihydrogen diphosphate)
  • 1D-Myo-inositol 5-diphosphate pentakisphosphate
  • 5-Diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate
  • 5-Diphospho-1D-myo-inositol pentakisphosphate
  • 5-PP-InsP5
Adenosine 5'-pentaphosphate
Adenosine tetraphosphate
  • Adenosine 5'-tetraphosphate
  • Adenosine tetraphosphate
  • Ap4
  • ATPP
  • P4A
58337-43-2
Diadenosine hexaphosphate
  • Adenosine 5'-(heptahydrogen hexaphosphate) P->5'-ester with adenosine
  • Adenosine 5'-(heptahydrogen hexaphosphate)5'-5'-ester with adenosine
  • Adenosine 5'-hexaphosphate 5'-ester with adenosine
  • Adenosine-(5')-hexaphospho-(5')-adenosine
  • Ap(6)A
56983-23-4
Myo-inositol hexakisphosphate
  • 1D-Myo-Inositol 1,2,3,4,5,6-hexakisphosphate
  • 1D-Myo-inositol hexakisphosphate
  • D-Myo-Inositol 1,2,3,4,5,6-hexakisphosphate
  • Inositol 1,2,3,4,5,6-hexakisphosphate
  • Myo-Inositol 1,2,3,4,5,6-hexakisphosphate
83-86-3
genes like me logo Genes that share compounds with NUDT11: view

Transcripts for NUDT11 Gene

mRNA/cDNA for NUDT11 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(68) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NUDT11 Gene

Nudix (nucleoside diphosphate linked moiety X)-type motif 11:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT11 Gene

No ASD Table

Relevant External Links for NUDT11 Gene

GeneLoc Exon Structure for
NUDT11
ECgene alternative splicing isoforms for
NUDT11

Expression for NUDT11 Gene

mRNA expression in normal human tissues for NUDT11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NUDT11 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x5.0), Brain - Anterior cingulate cortex (BA24) (x4.8), Brain - Hypothalamus (x4.7), Testis (x4.5), and Brain - Frontal Cortex (BA9) (x4.3).

Protein differential expression in normal tissues from HIPED for NUDT11 Gene

This gene is overexpressed in Heart (20.4), Fetal testis (12.5), Ovary (11.8), Testis (11.6), and Fetal Brain (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NUDT11 Gene



Protein tissue co-expression partners for NUDT11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NUDT11 Gene:

NUDT11

SOURCE GeneReport for Unigene cluster for NUDT11 Gene:

Hs.200016

mRNA Expression by UniProt/SwissProt for NUDT11 Gene:

Q96G61-NUD11_HUMAN
Tissue specificity: Mainly expressed in testis and, at lower level in brain. According to PubMed:12121577, it is also expressed in pancreas and weakly expressed in thymus, prostate, ovary, lung, small intestine and heart.
genes like me logo Genes that share expression patterns with NUDT11: view

Primer Products

Orthologs for NUDT11 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUDT11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUDT11 34 35
  • 99.59 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 96 (a)
ManyToMany
-- 35
  • 96 (a)
ManyToMany
LOC491890 34
  • 93.29 (n)
mouse
(Mus musculus)
Mammalia Nudt10 35
  • 96 (a)
ManyToMany
Nudt11 34 16 35
  • 88.01 (n)
cow
(Bos Taurus)
Mammalia NUDT11 34 35
  • 94.51 (n)
rat
(Rattus norvegicus)
Mammalia Nudt11 34
  • 87.8 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 82 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 72 (a)
ManyToMany
-- 35
  • 70 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 75 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 82 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii nudt4b 35
  • 73 (a)
ManyToMany
nudt4a 35
  • 58 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Aps 35
  • 52 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y92H12BL.5 35
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8787 35
  • 40 (a)
OneToMany
Species where no ortholog for NUDT11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NUDT11 Gene

ENSEMBL:
Gene Tree for NUDT11 (if available)
TreeFam:
Gene Tree for NUDT11 (if available)

Paralogs for NUDT11 Gene

Paralogs for NUDT11 Gene

(4) SIMAP similar genes for NUDT11 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NUDT11: view

Variants for NUDT11 Gene

Sequence variations from dbSNP and Humsavar for NUDT11 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs11091729 -- 51,492,673(+) CCCAG(C/T)CCATG intron-variant
rs111312303 -- 51,492,571(+) GGTTT(C/T)GCCAT intron-variant
rs111604355 -- 51,489,756(+) TCCAC(C/T)ACTAG downstream-variant-500B
rs111778123 -- 51,497,580(+) TTCAC(C/G)TGGAG upstream-variant-2KB
rs111787865 -- 51,496,782(+) TCGGG(G/T)GCGCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NUDT11 Gene

Variant ID Type Subtype PubMed ID
nsv471604 CNV gain 15918152
nsv524351 CNV gain 19592680

Variation tolerance for NUDT11 Gene

Residual Variation Intolerance Score: 33.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUDT11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUDT11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT11 Gene

Disorders for NUDT11 Gene

Relevant External Links for NUDT11

Genetic Association Database (GAD)
NUDT11
Human Genome Epidemiology (HuGE) Navigator
NUDT11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUDT11

No disorders were found for NUDT11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUDT11 Gene

Publications for NUDT11 Gene

  1. An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase. (PMID: 12105228) Hidaka K. … Shears S.B. (J. Biol. Chem. 2002) 2 3 4 22 64
  2. Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases. (PMID: 12121577) Leslie N.R. … Safrany S.T. (BMC Biochem. 2002) 3 4 22 64
  3. Replication of prostate cancer risk loci on 8q24, 11q13, 17q12, 19q33, and Xp11 in African Americans. (PMID: 19902474) Hooker S. … Kittles R.A. (Prostate 2010) 3 46 64
  4. Multiple newly identified loci associated with prostate cancer susceptibility. (PMID: 18264097) Eeles R.A. … Easton D.F. (Nat. Genet. 2008) 3 46 64
  5. Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. (PMID: 18264098) Gudmundsson J. … Stefansson K. (Nat. Genet. 2008) 3 46 64

Products for NUDT11 Gene

Sources for NUDT11 Gene

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