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GIFtS

NUDT11 Gene

protein-coding   GIFtS: 53
GCID: GC0XM051232

nudix (nucleoside diphosphate linked moiety X)-type motif...
 Explore 2 diseases affiliated with
NUDT11 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NUDT11    

Aliases
for NUDT11 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 111 2     HAps11
HDIPP3beta1     DIPP3B3 5
APS12 3 5     FLJ106281
DIPP3b1 2     ASP12
Diadenosine 5',5'''-P1,P6-Hexaphosphate Hydrolase 3-Beta2 3     DIPP3beta2
Diadenosine Hexaphosphate Hydrolase (AMP-Forming)2 3     Diphosphoinositol Polyphosphate Phosphohydrolase 3, Beta2
Nucleoside Diphosphate-Linked Moiety X Motif 112 3     Diphosphoinositol Polyphosphate Phosphohydrolase 3-Beta2
Nudix Motif 112 3     EC 3.6.1.523
DIPP-3-Beta1     EC 3.6.1.603
DIPP3-Beta1     

External Ids:    HGNC: 180111   Entrez Gene: 551902   Ensembl: ENSG000001963687   OMIM: 3005285   UniProtKB: Q96G613   

Export aliases for NUDT11 gene to outside databases

Previous GC identifers: GC0XP049645 GC0XM049277 GC0XM049917 GC0XM050149 GC0XM051065 GC0XM051249 GC0XM048674


Summaries
for NUDT11 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NUDT11:
NUDT11 belongs to a subgroup of phosphohydrolases that preferentially attack diphosphoinositol polyphosphates (Hidaka
et al., 2002 (PubMed 12105228)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: NUD11_HUMAN, Q96G61
Function: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate),
suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside
oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from
Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate

Gene Wiki entry for NUDT11


Genomic Views
for NUDT11 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_011638.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NUDT11 gene promoter:
         Elk-1   Spz1   Bach2   FOXD3   HSF1 (long)   FOXD1   S8   HSF1short   c-Myb   Ik-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for NUDT11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUDT11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.22   Ensembl cytogenetic band:  Xp11.22   HGNC cytogenetic band: Xp11.22-p11.1

NUDT11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUDT11 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM051232:  view genomic region     (about GC identifiers)

Start:
 51,232,863 bp from pter      End:
 51,239,459 bp from pter
Size:
 6,597 bases      Orientation:
 minus strand

Proteins
for NUDT11 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NUD11_HUMAN, Q96G61 (See protein sequence)
Recommended Name: Diphosphoinositol polyphosphate phosphohydrolase 3-beta  
Size: 164 amino acids; 18559 Da
Cofactor: Binds 3 magnesium or manganese ions per subunit (By similarity). Manganese may be the true cofactor in vivo
Subcellular location: Cytoplasm
Secondary accessions: Q9NVN0

Explore the universe of human proteins at neXtProt for NUDT11: NX_Q96G61

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96G61

    • NUDT11 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_060629.2  
    ENSEMBL proteins: 
     ENSP00000365160  
    Reactome Protein details: Q96G61
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: NUDT11
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    Novus Biologicals NUDT11 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NUDT11

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005737cytoplasm IEA--


    NUDT11 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for NUDT11

    Protein Domains /
    Families
    for NUDT11 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NUDT11 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015797 NUDIX_hydrolase_dom-like
     IPR020084 NUDIX_hydrolase_CS
     IPR000086 NUDIX_hydrolase_dom

    Graphical View of Domain Structure for InterPro Entry Q96G61

    ProtoNet protein and cluster: Q96G61

    1 Blocks protein family: IPB000086 NUDIX hydrolase

    UniProtKB/Swiss-Prot: NUD11_HUMAN, Q96G61
    Similarity: Belongs to the Nudix hydrolase family. DIPP subfamily
    Similarity: Contains 1 nudix hydrolase domain


    Function
    for NUDT11 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NUD11_HUMAN, Q96G61
    Function: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate),
    suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside
    oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from
    Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate
    Catalytic activity: Diphospho-myo-inositol polyphosphate + H(2)O = myo-inositol polyphosphate + phosphate
    Catalytic activity: P(1),P(6)-bis(5'-adenosyl)hexaphosphate + H(2)O = adenosine 5'-pentaphosphate + AMP
    Catalytic activity: P(1),P(5)-bis(5'-adenosyl)pentaphosphate + H(2)O = adenosine 5'-tetraphosphate + AMP
    Biophysicochemical properties: Kinetic parameters: KM=0.053 uM for PP-InsP5; KM=13 uM for Ap6A; KM=37 uM for Ap5A; pH
    dependence: Optimum pH is 8.5;

    Enzyme Numbers (IUBMB): EC 3.6.1.601 EC 3.6.1.521

    miRNA
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    8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate NUDT11 (see all 43):
    hsa-miR-607 hsa-miR-3607-3p hsa-miR-19b-2* hsa-miR-29a hsa-miR-548l hsa-miR-183* hsa-miR-3613-3p hsa-miR-3909
    SwitchGear 3'UTR luciferase reporter plasmid: NUDT11 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008486diphosphoinositol-polyphosphate diphosphatase activity ISS--
    GO:0046872metal ion binding IEA--
    GO:0052840inositol diphosphate tetrakisphosphate diphosphatase activity IEA--
    GO:0052843inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity IEA--
    GO:0052844inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity IEA--


    NUDT11 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for NUDT11:
     Increased gamma-H2AX phosphory 


    Pathways & Interactions
    for NUDT11 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Metabolism
    		Metabolism1.00
    2Synthesis of IP3 and IP4 in the cytosol
    		Inositol phosphate metabolism0.57
    3inositol pyrophosphates biosynthesis
    		Synthesis of pyrophosphates in the cytosol0.42

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for NUDT11
        Metabolism
    Synthesis of pyrophosphates in the cytosol
    Inositol phosphate metabolism



    NUDT11 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NUDT11

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for NUDT11 (Q96G613 ENSP000003651604) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RASSF1Q9NS233I2D: score=1 
    TRAF6Q9Y4K33I2D: score=1 
    --ENSP000003168404STRING: ENSP00000316840
    About this table

    Drugs & Compounds
    for NUDT11 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NUDT11

    7 HMDB Compounds for NUDT11    About this table
    CompoundSynonyms CAS #PubMed Ids
    5-Diphosphoinositol pentakisphosphate5-diphospho-1D-myo-inositol pentakisphosphate (see all 11)----
    Diadenosine hexaphosphateAdenosine 5'-(heptahydrogen hexaphosphate) P->5'-ester with adenosine (see all 9)56983-23-4--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--
    Myo-inositol hexakisphosphate1D-myo-Inositol 1,2,3,4,5,6-hexakisphosphate (see all 9)83-86-3--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    Search CenterWatch for drugs/clinical trials and news about NUDT11 / NUD11 

    Transcripts
    for NUDT11 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NUDT11 gene: 
    NM_018159.3  

    Unigene Cluster for NUDT11:

    Nudix (nucleoside diphosphate linked moiety X)-type motif 11
    Hs.200016  [show with all ESTs]
    Unigene Representative Sequence: NM_018159
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000375992(uc010njt.3)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NUDT11
    8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate NUDT11 (see all 43):
    hsa-miR-607 hsa-miR-3607-3p hsa-miR-19b-2* hsa-miR-29a hsa-miR-548l hsa-miR-183* hsa-miR-3613-3p hsa-miR-3909
    SwitchGear 3'UTR luciferase reporter plasmid: NUDT11 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NUDT11 (see all 4)
    OriGene shRNA RFP: NUDT11
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUDT11
    Clone
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    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NUDT11
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUDT11
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUDT11

    Additional cDNA sequence: 

    AK001490.1 BC009942.2 

    4 DOTS entries:

    DT.310582  DT.100816953  DT.121319044  DT.95164464 

    24/68 AceView cDNA sequences (see all 68):

    BQ218489 Z45045 BG178019 NM_018159 R12527 F07882 BQ959454 CK822952 
    BI546747 BE046911 BQ086279 BU623271 AW665496 BC009942 AI014587 BP335471 
    BX353795 BQ086300 AU280300 CA848859 AA885169 BQ102384 F07881 AI246497 

    GeneLoc Exon Structure


    Expression
    for NUDT11 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NUDT11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATACCAGTGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NUDT11 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyMetanephrosKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See NUDT11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NUDT11

    SOURCE GeneReport for Unigene cluster: Hs.200016

    UniProtKB/Swiss-Prot: NUD11_HUMAN, Q96G61
    Tissue specificity: Mainly expressed in testis and, at lower level in brain. According to PubMed:12121577, it is also
    expressed in pancreas and weakly expressed in thymus, prostate, ovary, lung, small intestine and heart

        SABiosciences Custom PCR Arrays for NUDT11
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    In Situ
    Assay Products:     
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    Orthologs
    for NUDT11 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NUDT11 gene from 7/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves NUDT46
    		 Uncharacterized protein
    		 80(a)
    		 1 → many
    		 1(46703880-46724579)
    lizard
    (Anolis carolinensis)    		 Reptilia NUDT46
    		 --
    		 81(a)
    		 1 → many
    		 5(31478853-31493709)
    zebrafish
    (Danio rerio)    		 Actinopterygii nudt4b6
    nudt4a6
    		 nudix (nucleoside diphosphate linked moiety X)-typ...
    nudix (nucleoside diphosphate linked moiety X)-typ...
    		 72(a)
    58(a)
    		 many ↔ many
    many ↔ many
    		 4(1648879-1662251)
    18(15474824-15516418)
    fruit fly
    (Drosophila melanogaster)    		 Insecta Aps6
    		 Aps
    		 51(a)
    		 1 → many
    		 3L(10887876-10892223)
    worm
    (Caenorhabditis elegans)    		 Secernentea Y92H12BL.56
    		 --
    		 37(a)
    		 1 → many
    		 I(1365311-1375885)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons NUDT186
    atnudt176
    (see all 7)    		 nudix hydrolase 17
    (see all 7)    		 26(a)
    25(a)
    (see all 7)    		 many ↔ many
    many ↔ many
    (see all 7)    		 1(5124742-5126151)
    2(296510-298101)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 7)    		 hydrolase, NUDIX family, domain containing protein...
    hydrolase, NUDIX family, domain containing protein...
    (see all 7)    		 27(a)
    26(a)
    (see all 7)    		 many ↔ many
    many ↔ many
    (see all 7)    		 2(30619799-30621022)
    6(8067592-8069045)


    ENSEMBL Gene Tree for NUDT11 (if available)
    TreeFam Gene Tree for NUDT11 (if available) 

    Paralogs
    for NUDT11 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NUDT11 gene
    NUDT42  NUDT32  NUDT102  
    3 SIMAP similar genes for NUDT11 using alignment to 1 protein entry:     NUD11_HUMAN:
    NUDT10    NUDT4    NUDT3

    NUDT11 for paralogs           About GeneDecksing



    Genomic Variants
    for NUDT11 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/74 NCBI SNPs in NUDT11 are shown (see all 74)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1913325751,2
    		--51232366(+) TTACAC/TGCAAT 1 -- int10--------
    rs1999842051,2
    		--51232385(+) ACTTT-/TAGTCAT 1 -- int10--------
    rs1835242651,2
    		--51232439(+) GTGCTA/GTCAAA 1 -- int10--------
    rs1885056381,2
    		--51232564(+) GGTAAA/TTAGTA 1 -- int10--------
    rs1116043551,2
    		C,--51232608(+) TCCACT/CACTAG 1 -- int11Minor allele frequency- C:0.00CSA 1
    rs2011676781,2
    		--51232653(+) AAGGG-/GATAAAG 1 -- int10--------
    rs2003092101,2
    		--51232656(+) GGGAT-/AAAGTC 1 -- int10--------
    rs1510991421,2
    		C,--51232709(+) ACTAAC/TGGAAG 1 -- int10--------
    rs1410339941,2
    		--51232784(+) TTTCTA/GGGCTG 1 -- int10--------
    rs1919782131,2
    		--51233103(+) TTAAAA/CCAACA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NUDT11 (51232863 - 51239459 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NUDT11: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for NUDT11 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NUDT11 for disorders           About GeneDecksing

    OMIM gene information: 300528    OMIM disorders: --

    2 diseases for NUDT11:    About MalaCards
    prostate cancer    prostatitis

    Human Genome Epidemiology (HuGE) Navigator: NUDT11 (7 documents)

    Export disorders for NUDT11 gene to outside databases

    Publications
    for NUDT11 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NUDT11 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with NUDT11)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase. (PubMed id 12105228)1, 2, 3, 9 Hidaka K.... Shears S.B. (2002)
    2. Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases. (PubMed id 12121577)1, 2, 9 Leslie N.R.... Safrany S.T. (2002)
    3. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate. (PubMed id 12370170)1, 2 Fisher D.I.... Cartwright J.L. (2002)
    7. Genetic and functional analyses implicate the NUDT11, HNF1B, and SLC22A3 genes in prostate cancer pathogenesis. (PubMed id 22730461)1 Grisanzio C....Freedman M.L. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Replication of prostate cancer risk loci on 8q24, 11q 13, 17q12, 19q33, and Xp11 in African Americans. (PubMed id 19902474)1 Hooker S....Kittles R.A. (2010)

    External Searches for NUDT11 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    Genome Databases showing NUDT11 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55190 HGNC: 18011 AceView: NUDT11 Ensembl:ENSG00000196368 euGenes: HUgn55190
    ECgene: NUDT11 H-InvDB: NUDT11

    Other Databases showing NUDT11 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NUDT11 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NUDT11 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NUDT11 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for NUDT11 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NUDT11 gene:
    Search GeneIP for patents involving NUDT11

    GeneCards and IP:
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