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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NUDT11 Gene

protein-coding   GIFtS: 56
GCID: GC0XM051232

Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 111 2     hDIPP3beta2 3
APS12 3 5     DIPP3B3 5
Diadenosine 5',5'''-P1,P6-Hexaphosphate Hydrolase 3-Beta2 3     ASP12
Diadenosine Hexaphosphate Hydrolase (AMP-Forming)2 3     DIPP3b2
Nucleoside Diphosphate-Linked Moiety X Motif 112 3     DIPP3beta2
Nudix Motif 112 3     Diphosphoinositol Polyphosphate Phosphohydrolase 3, Beta2
DIPP-3-beta2 3     Diphosphoinositol Polyphosphate Phosphohydrolase 3-Beta2
DIPP3-beta2 3     EC 3.6.1.523
hAps12 3     EC 3.6.1.603

External Ids:    HGNC: 180111   Entrez Gene: 551902   Ensembl: ENSG000001963687   OMIM: 3005285   UniProtKB: Q96G613   

Export aliases for NUDT11 gene to outside databases

Previous GC identifers: GC0XP049645 GC0XM049277 GC0XM049917 GC0XM050149 GC0XM051065 GC0XM051249 GC0XM048674


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NUDT11 Gene:
NUDT11 belongs to a subgroup of phosphohydrolases that preferentially attack diphosphoinositol polyphosphates
(Hidaka et al., 2002 (PubMed 12105228)).(supplied by OMIM, Mar 2008)

GeneCards Summary for NUDT11 Gene: 
NUDT11 (nudix (nucleoside diphosphate linked moiety X)-type motif 11) is a protein-coding gene. Diseases associated with NUDT11 include prostate cancer, and prostatitis, and among its related super-pathways are Synthesis of IP3 and IP4 in the cytosol and inositol pyrophosphates biosynthesis. GO annotations related to this gene include inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity and diphosphoinositol-polyphosphate diphosphatase activity. An important paralog of this gene is NUDT4.

UniProtKB/Swiss-Prot: NUD11_HUMAN, Q96G61
Function: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate),
suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside
oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a
from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate

Gene Wiki entry for NUDT11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_011638.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NUDT11 gene promoter:
         Elk-1   Spz1   Bach2   FOXD3   HSF1 (long)   FOXD1   S8   HSF1short   c-Myb   Ik-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for NUDT11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUDT11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.22   Ensembl cytogenetic band:  Xp11.22   HGNC cytogenetic band: Xp11.22-p11.1

NUDT11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUDT11 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM051232:  view genomic region     (about GC identifiers)

Start:
51,232,863 bp from pter      End:
51,239,459 bp from pter
Size:
6,597 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NUD11_HUMAN, Q96G61 (See protein sequence)
Recommended Name: Diphosphoinositol polyphosphate phosphohydrolase 3-beta  
Size: 164 amino acids; 18559 Da
Cofactor: Binds 3 magnesium or manganese ions per subunit (By similarity). Manganese may be the true cofactor in
vivo
Subcellular location: Cytoplasm
Secondary accessions: Q9NVN0

Explore the universe of human proteins at neXtProt for NUDT11: NX_Q96G61

Explore proteomics data for NUDT11 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96G61

  • NUDT11 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NUDT11 Protein Expression
    REFSEQ proteins: NP_060629.2  
    ENSEMBL proteins: 
     ENSP00000365160  
    Reactome Protein details: Q96G61
    Human Recombinant Protein Products for NUDT11: 
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    Cloud-Clone Corp. Proteins for NUDT11 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005829cytosol TAS--

    NUDT11 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    NUDT: Nudix motif containing

    3 InterPro protein domains:
     IPR015797 NUDIX_hydrolase_dom-like
     IPR020084 NUDIX_hydrolase_CS
     IPR000086 NUDIX_hydrolase_dom

    Graphical View of Domain Structure for InterPro Entry Q96G61

    ProtoNet protein and cluster: Q96G61

    1 Blocks protein domain: IPB000086 NUDIX hydrolase

    UniProtKB/Swiss-Prot: NUD11_HUMAN, Q96G61
    Similarity: Belongs to the Nudix hydrolase family. DIPP subfamily
    Similarity: Contains 1 nudix hydrolase domain


    NUDT11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NUD11_HUMAN, Q96G61
    Function: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate),
    suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside
    oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a
    from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate
    Catalytic activity: Diphospho-myo-inositol polyphosphate + H(2)O = myo-inositol polyphosphate + phosphate
    Catalytic activity: P(1),P(6)-bis(5'-adenosyl)hexaphosphate + H(2)O = adenosine 5'-pentaphosphate + AMP
    Catalytic activity: P(1),P(5)-bis(5'-adenosyl)pentaphosphate + H(2)O = adenosine 5'-tetraphosphate + AMP
    Biophysicochemical properties: Kinetic parameters: KM=0.053 uM for PP-InsP5; KM=13 uM for Ap6A; KM=37 uM for Ap5A;
    pH dependence: Optimum pH is 8.5;

         Enzyme Numbers (IUBMB): EC 3.6.1.601 EC 3.6.1.521

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008486diphosphoinositol-polyphosphate diphosphatase activity ISS--
    GO:0016787hydrolase activity ----
    GO:0046872metal ion binding IEA--
    GO:0052840inositol diphosphate tetrakisphosphate diphosphatase activity IEA--
    GO:0052843inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity IEA--
         
    NUDT11 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NUDT11:
     Increased gamma-H2AX phosphory 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidNUDT11 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NUDT11 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Synthesis of IP3 and IP4 in the cytosol
    Inositol phosphate metabolism0.57
    2inositol pyrophosphates biosynthesis
    Synthesis of pyrophosphates in the cytosol0.42
    3Metabolism
    Metabolism0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3        Reactome Pathways for NUDT11
        Metabolism
    Synthesis of pyrophosphates in the cytosol
    Inositol phosphate metabolism



    NUDT11 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NUDT11

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for NUDT11 (Q96G613 ENSP000003651604) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RASSF1Q9NS233I2D: score=1 
    TRAF6Q9Y4K33I2D: score=1 
    --ENSP000003168404STRING: ENSP00000316840
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0043647inositol phosphate metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    NUDT11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NUDT11 (NUD11)

    7 HMDB Compounds for NUDT11    About this table
    CompoundSynonyms CAS #PubMed Ids
    5-Diphosphoinositol pentakisphosphate5-diphospho-1D-myo-inositol pentakisphosphate (see all 11)----
    Diadenosine hexaphosphateAdenosine 5'-(heptahydrogen hexaphosphate) P->5'-ester with adenosine (see all 9)56983-23-4--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--
    Myo-inositol hexakisphosphate1D-myo-Inositol 1,2,3,4,5,6-hexakisphosphate (see all 9)83-86-3--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Search CenterWatch for drugs/clinical trials and news about NUDT11 / NUD11

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NUDT11 gene: 
    NM_018159.3  

    Unigene Cluster for NUDT11:

    Nudix (nucleoside diphosphate linked moiety X)-type motif 11
    Hs.200016  [show with all ESTs]
    Unigene Representative Sequence: NM_018159
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000375992(uc010njt.3)
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidNUDT11 3' UTR sequence
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    Additional mRNA sequence: 

    AK001490.1 BC009942.2 

    4 DOTS entries:

    DT.310582  DT.100816953  DT.121319044  DT.95164464 

    24/68 AceView cDNA sequences (see all 68):

    BC009942 BQ086279 Z45045 BQ218489 AI014587 BU623271 NM_018159 BG178019 
    BI546747 AW665496 F07882 CK822952 BE046911 BQ959454 R12527 BX419243 
    CK005325 BM728376 BP335471 AA992099 BQ102368 CA848859 BM903697 CA441752 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NUDT11 expression in normal human tissues (normalized intensities)      NUDT11 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATACCAGTGA
    NUDT11 Expression
    About this image


    NUDT11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Presumptive Podocytes Podocyte Layer
             Metanephros
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Testis (Reproductive System)

    See NUDT11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NUDT11

    SOURCE GeneReport for Unigene cluster: Hs.200016

    UniProtKB/Swiss-Prot: NUD11_HUMAN, Q96G61
    Tissue specificity: Mainly expressed in testis and, at lower level in brain. According to PubMed:12121577, it is
    also expressed in pancreas and weakly expressed in thymus, prostate, ovary, lung, small intestine and heart

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDT11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NUDT11 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nudt111 , 5 nudix (nucleoside diphosphate linked moiety X)-type more1, 5 88.01(n)1
    95.73(a)1
      X (2.68 cM)5
    582421  NM_021431.21  NP_067406.21 
     60474535 
    chicken
    (Gallus gallus)
    Aves --
    --
    75(a)
    1 → many
    1(44690009-44710912)
    lizard
    (Anolis carolinensis)
    Reptilia NUDT46
    Uncharacterized protein
    82(a)
    1 → many
    5(31478850-31494149)
    zebrafish
    (Danio rerio)
    Actinopterygii nudt4b6
    nudt4a6
    nudix (nucleoside diphosphate linked moiety X)-typ...
    nudix (nucleoside diphosphate linked moiety X)-typ...
    72(a)
    58(a)
    many ↔ many
    many ↔ many
    4(1648879-1662251)
    18(15474824-15516418)
    fruit fly
    (Drosophila melanogaster)
    Insecta Aps6
    Aps
    50(a)
    1 → many
    3L(10887876-10892223)
    worm
    (Caenorhabditis elegans)
    Secernentea Y92H12BL.56
    Protein Y92H12BL.5
    38(a)
    1 → many
    I(1365309-1375883)


    ENSEMBL Gene Tree for NUDT11 (if available)
    TreeFam Gene Tree for NUDT11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NUDT11 gene
    NUDT42  NUDT32  NUDT102  
    3 SIMAP similar genes for NUDT11 using alignment to 1 protein entry:     NUD11_HUMAN:
    NUDT10    NUDT4    NUDT3

    NUDT11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/99 SNPs in NUDT11 are shown (see all 99)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0227384
    ----see VAR_0227382 S N mis40--------
    rs1913325751,2
    --51232366(+) TTACAC/TGCAAT 1 -- int10--------
    rs1999842051,2
    C--51232385(+) ACTTT-/TAGTCAT 1 -- int10--------
    rs1835242651,2
    --51232439(+) GTGCTA/GTCAAA 1 -- int10--------
    rs1885056381,2
    --51232564(+) GGTAAA/TTAGTA 1 -- int10--------
    rs1116043551,2
    C,F--51232608(+) TCCACT/CACTAG 1 -- int11Minor allele frequency- C:0.00CSA 1
    rs2011676781,2
    --51232653(+) AAGGG-/GATAAAG 1 -- int10--------
    rs2003092101,2
    --51232656(+) GGGAT-/AAAGTC 1 -- int10--------
    rs1510991421,2
    C--51232709(+) ACTAAC/TGGAAG 1 -- int10--------
    rs1410339941,2
    --51232784(+) TTTCTA/GGGCTG 1 -- int10--------

    HapMap Linkage Disequilibrium report for NUDT11 (51232863 - 51239459 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NUDT11:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv524351CNV Gain19592680
    nsv471604CNV Gain15918152

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300528    OMIM disorders: --

    2 diseases for NUDT11:    About MalaCards
    prostate cancer    prostatitis


    NUDT11 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NUDT11
    Human Genome Epidemiology (HuGE) Navigator: NUDT11 (7 documents)

    Export disorders for NUDT11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NUDT11 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with NUDT11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase. (PubMed id 12105228)1, 2, 3, 9 Hidaka K.... Shears S.B. (2002)
    2. Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases. (PubMed id 12121577)1, 2, 9 Leslie N.R.... Safrany S.T. (2002)
    3. Replication of prostate cancer risk loci on 8q24, 11q 13, 17q12, 19q33, and Xp11 in African Americans. (PubMed id 19902474)1, 4 Hooker S....Kittles R.A. (2010)
    4. Multiple newly identified loci associated with prostate cancer susceptibility. (PubMed id 18264097)1, 4 Eeles R.A....Easton D.F. (2008)
    5. Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. (PubMed id 18264098)1, 4 Gudmundsson J.... Stefansson K. (2008)
    6. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate. (PubMed id 12370170)1, 2 Fisher D.I.... Cartwright J.L. (2002)
    10. Genetic and functional analyses implicate the NUDT11, HNF1B, and SLC22A3 genes in prostate cancer pathogenesis. (PubMed id 22730461)1 Grisanzio C....Freedman M.L. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55190 HGNC: 18011 AceView: NUDT11 Ensembl:ENSG00000196368 euGenes: HUgn55190
    ECgene: NUDT11 H-InvDB: NUDT11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NUDT11 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NUDT11 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NUDT11 gene:
    Search GeneIP for patents involving NUDT11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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