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Aliases for NUDT10 Gene

Aliases for NUDT10 Gene

  • Nudix Hydrolase 10 2 3 5
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 10 2 3
  • Diadenosine 5,5-P1,P6-Hexaphosphate Hydrolase 3-Alpha 3 4
  • Diadenosine Hexaphosphate Hydrolase (AMP-Forming) 3 4
  • Nucleoside Diphosphate-Linked Moiety X Motif 10 3 4
  • Nudix Motif 10 3 4
  • DIPP3-Alpha 3 4
  • DIPP3a 3 4
  • APS2 3 4
  • Diphosphoinositol Polyphosphate Phosphohydrolase 3-Alpha 3
  • DIPP-3-Alpha 4
  • HDIPP3alpha 4
  • EC 3.6.1.52 4
  • EC 3.6.1.60 4
  • HAps2 4

External Ids for NUDT10 Gene

Previous GeneCards Identifiers for NUDT10 Gene

  • GC0XU990383
  • GC0XP049120
  • GC0XP049759
  • GC0XP049991
  • GC0XP050908
  • GC0XP051091
  • GC0XP048516

Summaries for NUDT10 Gene

Entrez Gene Summary for NUDT10 Gene

  • This gene is a member of the nudix (nucleoside diphosphate linked moiety X)-type motif containing family. The encoded protein is a phosphohydrolase and may regulate the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to the regulation of intracellular trafficking. In some populations putative prostate cancer susceptibility alleles have been identified for this gene. Alternatively spliced transcript variants, which differ only in the 5' UTR, have been found for this gene. [provided by RefSeq, Feb 2015]

GeneCards Summary for NUDT10 Gene

NUDT10 (Nudix Hydrolase 10) is a Protein Coding gene. Diseases associated with NUDT10 include Prostate Cancer Susceptibility and Autoimmune Disease Of Endocrine System. Among its related pathways are Metabolism and Inositol phosphate metabolism (REACTOME). GO annotations related to this gene include hydrolase activity and inositol diphosphate tetrakisphosphate diphosphatase activity. An important paralog of this gene is NUDT11.

UniProtKB/Swiss-Prot for NUDT10 Gene

  • Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT10 Gene

Genomics for NUDT10 Gene

Regulatory Elements for NUDT10 Gene

Enhancers for NUDT10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF051395 0.7 ENCODE 11.5 +64.1 64134 1.5 CTCF PKNOX1 L3MBTL2 ETV1 ZBTB8A ZEB2 GABPA ZFHX2 SCRT2 ZBTB26 NUDT10 ENSG00000229151 LOC100419238
GH0XF051332 0.7 ENCODE 10.9 +0.5 523 1.1 KLF1 PKNOX1 MAZ SP3 L3MBTL2 SP2 ZBTB8A GLIS2 ZNF366 POLR2A NUDT10 PIR56688
GH0XF051333 0.2 ENCODE 0.8 +1.4 1389 0.0 NUDT10 PIR56688
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NUDT10 on UCSC Golden Path with GeneCards custom track

Promoters for NUDT10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001917246 970 1999 KLF1 PKNOX1 MAZ SP3 L3MBTL2 SP2 ZBTB8A GLIS2 ZNF366 POLR2A

Genomic Location for NUDT10 Gene

Chromosome:
X
Start:
51,332,231 bp from pter
End:
51,337,525 bp from pter
Size:
5,295 bases
Orientation:
Plus strand

Genomic View for NUDT10 Gene

Genes around NUDT10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDT10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDT10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT10 Gene

Proteins for NUDT10 Gene

  • Protein details for NUDT10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFP7-NUD10_HUMAN
    Recommended name:
    Diphosphoinositol polyphosphate phosphohydrolase 3-alpha
    Protein Accession:
    Q8NFP7
    Secondary Accessions:
    • A8K7D7
    • D3DX69
    • Q86VK1
    • Q86VR0

    Protein attributes for NUDT10 Gene

    Size:
    164 amino acids
    Molecular mass:
    18500 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NUDT10 Gene

neXtProt entry for NUDT10 Gene

Post-translational modifications for NUDT10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUDT10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NUDT10 Gene

Domains & Families for NUDT10 Gene

Gene Families for NUDT10 Gene

Protein Domains for NUDT10 Gene

Suggested Antigen Peptide Sequences for NUDT10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NFP7

UniProtKB/Swiss-Prot:

NUD10_HUMAN :
  • Contains 1 nudix hydrolase domain.
  • Belongs to the Nudix hydrolase family. DIPP subfamily.
Domain:
  • Contains 1 nudix hydrolase domain.
Family:
  • Belongs to the Nudix hydrolase family. DIPP subfamily.
genes like me logo Genes that share domains with NUDT10: view

Function for NUDT10 Gene

Molecular function for NUDT10 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.088 uM for PP-InsP5 {ECO:0000269 PubMed:12105228, ECO:0000269 PubMed:12121577}; KM=19 uM for Ap6A {ECO:0000269 PubMed:12105228, ECO:0000269 PubMed:12121577}; KM=50 uM for Ap5A {ECO:0000269 PubMed:12105228, ECO:0000269 PubMed:12121577}; pH dependence: Optimum pH is 8.5. {ECO:0000269 PubMed:12105228, ECO:0000269 PubMed:12121577};
UniProtKB/Swiss-Prot CatalyticActivity:
Diphospho-myo-inositol polyphosphate + H(2)O = myo-inositol polyphosphate + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
P(1),P(6)-bis(5-adenosyl)hexaphosphate + H(2)O = adenosine 5-pentaphosphate + AMP.
UniProtKB/Swiss-Prot CatalyticActivity:
P(1),P(5)-bis(5-adenosyl)pentaphosphate + H(2)O = adenosine 5-tetraphosphate + AMP.
UniProtKB/Swiss-Prot Function:
Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.

Enzyme Numbers (IUBMB) for NUDT10 Gene

Gene Ontology (GO) - Molecular Function for NUDT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000298 endopolyphosphatase activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity ISS,IBA --
GO:0016787 hydrolase activity IEA --
GO:0034431 bis(5-adenosyl)-hexaphosphatase activity IBA --
genes like me logo Genes that share ontologies with NUDT10: view
genes like me logo Genes that share phenotypes with NUDT10: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NUDT10 Gene

Localization for NUDT10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDT10 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUDT10 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NUDT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IEA,IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NUDT10: view

Pathways & Interactions for NUDT10 Gene

genes like me logo Genes that share pathways with NUDT10: view

Pathways by source for NUDT10 Gene

Gene Ontology (GO) - Biological Process for NUDT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043647 inositol phosphate metabolic process TAS --
GO:0071543 diphosphoinositol polyphosphate metabolic process IBA --
GO:1901907 diadenosine pentaphosphate catabolic process IBA --
GO:1901909 diadenosine hexaphosphate catabolic process IBA --
GO:1901911 adenosine 5-(hexahydrogen pentaphosphate) catabolic process IBA --
genes like me logo Genes that share ontologies with NUDT10: view

No data available for SIGNOR curated interactions for NUDT10 Gene

Drugs & Compounds for NUDT10 Gene

(5) Drugs for NUDT10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Manganese Approved Nutra 34
Magnesium Nutra 0

(3) Additional Compounds for NUDT10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 5'-pentaphosphate
Adenosine tetraphosphate
  • Adenosine 5'-tetraphosphate
  • Adenosine tetraphosphate
  • Ap4
  • ATPP
  • P4A
58337-43-2
Diadenosine hexaphosphate
  • Adenosine 5'-(heptahydrogen hexaphosphate) P->5'-ester with adenosine
  • Adenosine 5'-(heptahydrogen hexaphosphate)5'-5'-ester with adenosine
  • Adenosine 5'-hexaphosphate 5'-ester with adenosine
  • Adenosine-(5')-hexaphospho-(5')-adenosine
  • Ap(6)A
56983-23-4
genes like me logo Genes that share compounds with NUDT10: view

Transcripts for NUDT10 Gene

mRNA/cDNA for NUDT10 Gene

Unigene Clusters for NUDT10 Gene

Nudix (nucleoside diphosphate linked moiety X)-type motif 10:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT10 Gene

No ASD Table

Relevant External Links for NUDT10 Gene

GeneLoc Exon Structure for
NUDT10
ECgene alternative splicing isoforms for
NUDT10

Expression for NUDT10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NUDT10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NUDT10 Gene

This gene is overexpressed in Testis (x4.5) and Brain - Anterior cingulate cortex (BA24) (x4.2).

Protein differential expression in normal tissues from HIPED for NUDT10 Gene

This gene is overexpressed in Fetal testis (19.1), Testis (13.0), Ovary (9.1), and Fetal ovary (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NUDT10 Gene



Protein tissue co-expression partners for NUDT10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NUDT10 Gene:

NUDT10

SOURCE GeneReport for Unigene cluster for NUDT10 Gene:

Hs.375178

mRNA Expression by UniProt/SwissProt for NUDT10 Gene:

Q8NFP7-NUD10_HUMAN
Tissue specificity: Mainly expressed in testis and, at lower level in brain. According to PubMed:12121577, it is widely expressed.
genes like me logo Genes that share expression patterns with NUDT10: view

Orthologs for NUDT10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NUDT10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NUDT11 35
  • 95 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 95 (a)
ManyToMany
-- 35
  • 95 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Nudt10 35
  • 95 (a)
ManyToMany
Nudt11 35
  • 95 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 81 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 72 (a)
ManyToMany
-- 35
  • 69 (a)
ManyToMany
-- 35
  • 52 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 74 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 82 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii nudt4b 35
  • 72 (a)
ManyToMany
nudt4a 35
  • 58 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Aps 35
  • 52 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y92H12BL.5 35
  • 37 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DDP1 37
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8787 35
  • 39 (a)
OneToMany
Species where no ortholog for NUDT10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NUDT10 Gene

ENSEMBL:
Gene Tree for NUDT10 (if available)
TreeFam:
Gene Tree for NUDT10 (if available)

Paralogs for NUDT10 Gene

Paralogs for NUDT10 Gene

(4) SIMAP similar genes for NUDT10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NUDT10: view

Variants for NUDT10 Gene

Sequence variations from dbSNP and Humsavar for NUDT10 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs111867693 -- 51,335,316(+) AAAAA(A/T)AAAAA intron-variant
rs111907406 -- 51,334,186(+) AAAAT(A/T)TTCAC intron-variant
rs113174875 -- 51,332,460(+) GCCCC(A/C)GGAGT intron-variant, upstream-variant-2KB
rs113830224 -- 51,334,195(+) ACAAG(A/T)AATTT intron-variant
rs1144825 -- 51,334,145(-) AAAAA(G/T)AAATT intron-variant

Variation tolerance for NUDT10 Gene

Residual Variation Intolerance Score: 45.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUDT10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUDT10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NUDT10 Gene

Disorders for NUDT10 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NUDT10 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NUDT10

Genetic Association Database (GAD)
NUDT10
Human Genome Epidemiology (HuGE) Navigator
NUDT10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUDT10
genes like me logo Genes that share disorders with NUDT10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUDT10 Gene

Publications for NUDT10 Gene

  1. An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase. (PMID: 12105228) Hidaka K. … Shears S.B. (J. Biol. Chem. 2002) 2 3 4 22 64
  2. Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases. (PMID: 12121577) Leslie N.R. … Safrany S.T. (BMC Biochem. 2002) 3 4 22 64
  3. Prostate cancer risk-associated variants reported from genome-wide association studies: meta-analysis and their contribution to genetic Variation. (PMID: 20564319) Kim S.T. … Sun J. (Prostate 2010) 3 46 64
  4. Multiple newly identified loci associated with prostate cancer susceptibility. (PMID: 18264097) Eeles R.A. … Easton D.F. (Nat. Genet. 2008) 3 46 64
  5. Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. (PMID: 18264098) Gudmundsson J. … Stefansson K. (Nat. Genet. 2008) 3 46 64

Products for NUDT10 Gene

Sources for NUDT10 Gene

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