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NUDT10 Gene

protein-coding   GIFtS: 56
GCID: GC0XP051091

Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 101 2     hAps22 3
APS22 3 5     hDIPP3alpha2 3
Diadenosine 5',5'''-P1,P6-Hexaphosphate Hydrolase 3-Alpha2 3     DIPP3A3 5
Diadenosine Hexaphosphate Hydrolase (AMP-Forming)2 3     DIPP3a2
Nucleoside Diphosphate-Linked Moiety X Motif 102 3     Diphosphoinositol Polyphosphate Phosphohydrolase 3-Alpha2
Nudix Motif 102 3     Diphosphoinositol Polyphosphate Phosphohydrolase Type 3 Alpha2
DIPP-3-alpha2 3     EC 3.6.1.523
DIPP3-alpha2 3     EC 3.6.1.603

External Ids:    HGNC: 176211   Entrez Gene: 1706852   Ensembl: ENSG000001228247   OMIM: 3005275   UniProtKB: Q8NFP73   

Export aliases for NUDT10 gene to outside databases

Previous GC identifers: GC0XU990383 GC0XP049120 GC0XP049759 GC0XP049991 GC0XP050908 GC0XP048516


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NUDT10 Gene:
NUDT10 belongs to a subgroup of phosphohydrolases that preferentially attack diphosphoinositol polyphosphates
(Hidaka et al., 2002 (PubMed 12105228)).(supplied by OMIM, Mar 2008)

GeneCards Summary for NUDT10 Gene:
NUDT10 (nudix (nucleoside diphosphate linked moiety X)-type motif 10) is a protein-coding gene. GO annotations related to this gene include inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity and diphosphoinositol-polyphosphate diphosphatase activity. An important paralog of this gene is NUDT4.

UniProtKB/Swiss-Prot: NUD10_HUMAN, Q8NFP7
Function: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate),
suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside
oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a
from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_011630.15  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NUDT10 gene promoter:
         Nkx3-1   Nkx3-1 v4   Spz1   HSF1 (long)   Nkx3-1 v1   GATA-1   Nkx3-1 v2   Nkx3-1 v3   HSF1short   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NUDT10 promoter sequence
   Search Chromatin IP Primers for NUDT10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NUDT10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.23   Ensembl cytogenetic band:  Xp11.22   HGNC cytogenetic band: Xp11.22-p11.1

NUDT10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUDT10 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP051091:  view genomic region     (about GC identifiers)

Start:
51,075,083 bp from pter      End:
51,080,377 bp from pter
Size:
5,295 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NUD10_HUMAN, Q8NFP7 (See protein sequence)
Recommended Name: Diphosphoinositol polyphosphate phosphohydrolase 3-alpha  
Size: 164 amino acids; 18500 Da
Cofactor: Binds 3 magnesium or manganese ions per subunit (By similarity). Manganese may be the true cofactor in
vivo
1 PDB 3D structure from and Proteopedia for NUDT10:
3MCF (3D)    
Secondary accessions: A8K7D7 D3DX69 Q86VK1 Q86VR0

Explore the universe of human proteins at neXtProt for NUDT10: NX_Q8NFP7

Explore proteomics data for NUDT10 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NUDT10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_694853.1  
    ENSEMBL proteins: 
     ENSP00000365174   ENSP00000348831  
    Reactome Protein details: Q8NFP7

    NUDT10 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NUDT: Nudix motif containing

    3 InterPro protein domains:
     IPR015797 NUDIX_hydrolase_dom-like
     IPR020084 NUDIX_hydrolase_CS
     IPR000086 NUDIX_hydrolase_dom

    Graphical View of Domain Structure for InterPro Entry Q8NFP7

    ProtoNet protein and cluster: Q8NFP7

    1 Blocks protein domain: IPB000086 NUDIX hydrolase

    UniProtKB/Swiss-Prot: NUD10_HUMAN, Q8NFP7
    Similarity: Belongs to the Nudix hydrolase family. DIPP subfamily
    Similarity: Contains 1 nudix hydrolase domain


    Find genes that share domains with NUDT10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NUD10_HUMAN, Q8NFP7
    Function: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate),
    suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside
    oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a
    from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate
    Catalytic activity: Diphospho-myo-inositol polyphosphate + H(2)O = myo-inositol polyphosphate + phosphate
    Catalytic activity: P(1),P(6)-bis(5'-adenosyl)hexaphosphate + H(2)O = adenosine 5'-pentaphosphate + AMP
    Catalytic activity: P(1),P(5)-bis(5'-adenosyl)pentaphosphate + H(2)O = adenosine 5'-tetraphosphate + AMP
    Biophysicochemical properties: Kinetic parameters: KM=0.088 uM for PP-InsP5; KM=19 uM for Ap6A; KM=50 uM for Ap5A;
    pH dependence: Optimum pH is 8.5;

         Enzyme Numbers (IUBMB): EC 3.6.1.601 EC 3.6.1.521

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008486diphosphoinositol-polyphosphate diphosphatase activity ISS--
    GO:0016787hydrolase activity ----
    GO:0046872metal ion binding IEA--
    GO:0052840inositol diphosphate tetrakisphosphate diphosphatase activity IEA--
    GO:0052843inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity IEA--
         
    Find genes that share ontologies with NUDT10           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for NUDT10

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    hsa-miR-3146 hsa-let-7a-2* hsa-miR-219-5p hsa-miR-301a hsa-miR-342-3p hsa-miR-764 hsa-miR-218 hsa-miR-1276
    SwitchGear 3'UTR luciferase reporter plasmidNUDT10 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NUD10_HUMAN, Q8NFP7: Cytoplasm (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    Find genes that share ontologies with NUDT10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NUDT10 About    
    See pathways by source

    SuperPathContained pathways About
    1Inositol phosphate metabolism (REACTOME)
    Inositol phosphate metabolism0.59
    Synthesis of pyrophosphates in the cytosol0.00
    2Metabolism
    Metabolism0.38


    Find genes that share SuperPaths with NUDT10           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for NUDT10
        Synthesis of pyrophosphates in the cytosol


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NUDT10
    Interactions:

        Search GeneGlobe Interaction Network for NUDT10

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for NUDT10 (Q8NFP72, 3 ENSP000003488314) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RASSF1Q9NS232, 3, ENSP000003495474MINT-65627 I2D: score=3 STRING: ENSP00000349547
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0043647inositol phosphate metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with NUDT10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for NUDT10 (NUD10)

    3 HMDB Compounds for NUDT10    About this table
    CompoundSynonyms CAS #PubMed Ids
    Diadenosine hexaphosphateAdenosine 5'-(heptahydrogen hexaphosphate) P->5'-ester with adenosine (see all 9)56983-23-4--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NUDT10 gene: 
    NM_153183.2  

    Unigene Cluster for NUDT10:

    Nudix (nucleoside diphosphate linked moiety X)-type motif 10
    Hs.375178  [show with all ESTs]
    Unigene Representative Sequence: AF469196
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376006(uc004dph.3) ENST00000356450(uc004dpi.4)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NUDT10 (see all 33):
    hsa-miR-3146 hsa-let-7a-2* hsa-miR-219-5p hsa-miR-301a hsa-miR-342-3p hsa-miR-764 hsa-miR-218 hsa-miR-1276
    SwitchGear 3'UTR luciferase reporter plasmidNUDT10 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat NUDT10
      QuantiFast Probe-based Assays in human, mouse, rat NUDT10

    Additional mRNA sequence: 

    AF469196.1 AK291952.1 BC049383.1 BC050700.1 

    5 DOTS entries:

    DT.212184  DT.95164464  DT.97773825  DT.310582  DT.100831069 

    Selected AceView cDNA sequences (see all 44):

    BI752101 AA400002 AA044168 AI333197 F02214 AL045306 AA401433 F08892 
    BC050700 Z43657 F02965 AA861744 BC049383 F11229 NM_153183 AF469196 
    BM546876 BX461575 BI597752 BG772465 BX449264 AW104957 BX092714 BQ438669 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NUDT10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCTAGTTTC
    NUDT10 Expression
    About this image


    NUDT10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Testis (Reproductive System)
    NUDT10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NUDT10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.375178

    UniProtKB/Swiss-Prot: NUD10_HUMAN, Q8NFP7
    Tissue specificity: Mainly expressed in testis and, at lower level in brain. According to PubMed:12121577, it is
    widely expressed

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NUDT10 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nudt105 nudix (nucleoside diphosphate linked moiety X)-type more   --   X (2.74 cM) 6168696 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    74(a)
    1 → many
    1(44690009-44710912)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    82(a)
    1 → many
    5(31478850-31494149)
    zebrafish
    (Danio rerio)
    Actinopterygii nudt4b6
    nudt4a6
    nudix (nucleoside diphosphate linked moiety X)-typ...
    nudix (nucleoside diphosphate linked moiety X)-typ...
    72(a)
    58(a)
    many ↔ many
    many ↔ many
    4(1648879-1662251) ENSDARG00000045878
    18(15474824-15516418) ENSDARG00000057767
    fruit fly
    (Drosophila melanogaster)
    Insecta Aps6
    Aps
    52(a)
    1 → many
    3L(10887876-10892223)
    worm
    (Caenorhabditis elegans)
    Secernentea Y92H12BL.56
    Protein Y92H12BL.5 (Y92H12BL.5) mRNA, complete cds...
    37(a)
    1 → many
    I(1365309-1375883) WBGene00022366


    ENSEMBL Gene Tree for NUDT10 (if available)
    TreeFam Gene Tree for NUDT10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NUDT10 gene
    NUDT42  NUDT112  NUDT32  
    4 SIMAP similar genes for NUDT10 using alignment to 1 protein entry:     NUD10_HUMAN:
    NUDT11    NUDT4    NUDT3    RPS10-NUDT3

    Find genes that share paralogs with NUDT10           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NUDT10 (see all 102)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1509554841,2
    C--51073163(+) AAGAGC/TGAAAA 1 -- us2k10--------
    rs11517131,2
    C,F,A,H--51073275(+) CCAGAA/GACAAT 1 -- us2k119Minor allele frequency- G:0.22NA EA NS WA CSA 2148
    rs1929404561,2
    --51073335(+) TGTAAC/TAATCT 1 -- us2k10--------
    rs1850493751,2
    --51073396(+) AAATAC/TGCAAA 1 -- us2k10--------
    rs1887606161,2
    --51073457(+) AAAAGC/TCTTAG 1 -- us2k10--------
    rs19854641,2
    C,F,H--51073483(-) ATAATA/GTAGTA 1 -- us2k18Minor allele frequency- G:0.14NS EA NA 838
    rs558542081,2
    C--51073665(+) GGTGGC/TAGAAG 1 -- us2k10--------
    rs1924689971,2
    --51073770(+) ACTATC/TACACA 1 -- us2k10--------
    rs1850732941,2
    --51073787(+) ACCAAA/GCCATG 1 -- us2k10--------
    rs1882689151,2
    --51074007(+) GTTTCA/GGTCTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NUDT10 (51075083 - 51080377 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NUDT10: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NUDT10
    DNA2.0 Custom Variant and Variant Library Synthesis for NUDT10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300527    OMIM disorders: --

    3 diseases from the University of Copenhagen DISEASES database for NUDT10:
    Addison's disease     Candidiasis     Hypersensitivity reaction type II disease

    Find genes that share disorders with NUDT10           About GenesLikeMe

    Genetic Association Database (GAD): NUDT10
    Human Genome Epidemiology (HuGE) Navigator: NUDT10 (4 documents)

    Export disorders for NUDT10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NUDT10 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with NUDT10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase. (PubMed id 12105228)1, 2, 3, 9 Hidaka K.... Shears S.B. (J. Biol. Chem. 2002)
    2. Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases. (PubMed id 12121577)1, 2, 9 Leslie N.R.... Safrany S.T. (BMC Biochem. 2002)
    3. Prostate cancer risk-associated variants reported from genome-wide association studies: meta-analysis and their contribution to genetic Variation. (PubMed id 20564319)1, 4 Kim S.T....Sun J. (Prostate 2010)
    4. Multiple newly identified loci associated with prostate cancer susceptibility. (PubMed id 18264097)1, 4 Eeles R.A.... Easton D.F. (Nat. Genet. 2008)
    5. Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. (PubMed id 18264098)1, 4 Gudmundsson J.... Stefansson K. (Nat. Genet. 2008)
    6. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate. (PubMed id 12370170)1, 2 Fisher D.I.... Cartwright J.L. (J. Biol. Chem. 2002)
    9. Validation of genome-wide prostate cancer associations in men of African descent. (PubMed id 21071540)1 Chang B.L....Rebbeck T.R. (amp 2011)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 170685 HGNC: 17621 AceView: NUDT10 Ensembl:ENSG00000122824 euGenes: HUgn170685
    ECgene: NUDT10 H-InvDB: NUDT10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NUDT10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NUDT10 gene:
    Search GeneIP for patents involving NUDT10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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