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Aliases for NUDT1 Gene

Aliases for NUDT1 Gene

  • Nudix Hydrolase 1 2 3 5
  • Nudix Motif 1 2 3 4
  • 8-Oxo-DGTPase 2 3 4
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 2 3
  • Nucleoside Diphosphate-Linked Moiety X-Type Motif 1 2 3
  • 8-Oxo-7,8-Dihydrodeoxyguanosine Triphosphatase 2 3
  • Nucleoside Diphosphate-Linked Moiety X Motif 1 3 4
  • 8-Oxo-7,8-Dihydroguanosine Triphosphatase 2 3
  • 7,8-Dihydro-8-Oxoguanine Triphosphatase 2 3
  • 2-Hydroxy-DATP Diphosphatase 3 4
  • MutT Human Homolog 1 2 3
  • MTH1 3 4
  • EC 3.6.1.55 4
  • EC 3.6.1.56 4

External Ids for NUDT1 Gene

Previous HGNC Symbols for NUDT1 Gene

  • MTH1

Previous GeneCards Identifiers for NUDT1 Gene

  • GC07P001926
  • GC07P002026
  • GC07P002055
  • GC07P002248
  • GC07P002281

Summaries for NUDT1 Gene

Entrez Gene Summary for NUDT1 Gene

  • Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for NUDT1 Gene

NUDT1 (Nudix Hydrolase 1) is a Protein Coding gene. Diseases associated with NUDT1 include Myxosarcoma and Attenuated Familial Adenomatous Polyposis. Among its related pathways are Metabolism and Purine metabolism (REACTOME). GO annotations related to this gene include hydrolase activity and snoRNA binding.

UniProtKB/Swiss-Prot for NUDT1 Gene

  • Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.

Gene Wiki entry for NUDT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT1 Gene

Genomics for NUDT1 Gene

Regulatory Elements for NUDT1 Gene

Enhancers for NUDT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F002195 0.2 ENCODE 22.3 -46.0 -46004 1.1 ZNF121 NUDT1 MAD1L1 MRM2 GC07P002200 GC07P002190
GH07F002236 1.3 FANTOM5 Ensembl ENCODE 17.2 -4.6 -4634 2.3 HDGF TBP PKNOX1 BMI1 ZBTB40 RFX5 ZNF121 EGR1 ZNF143 ETV6 NUDT1 MRM2 LFNG SNX8 MAD1L1
GH07F002096 0.8 FANTOM5 Ensembl ENCODE 17.1 -143.4 -143434 4.4 HDGF HDAC1 PKNOX1 ARID4B ZNF48 ZBTB40 RAD21 ELK1 ZNF143 CREM MRM2 MAD1L1 NUDT1 IQCE GC07P002097 LOC105375127
GH07F002093 0.9 FANTOM5 ENCODE 17.1 -148.6 -148610 1.1 MNT MAFK NFE2L2 MAD1L1 NUDT1 MRM2 GC07M002088 GC07P002097
GH07F002231 0.2 ENCODE 16.9 -8.8 -8808 3.4 HDGF PKNOX1 ATF1 ARNT CREB3L1 ARID4B SIN3A YBX1 DMAP1 BRCA1 NUDT1 MRM2 MAD1L1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NUDT1 on UCSC Golden Path with GeneCards custom track

Promoters for NUDT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000620914 -222 2001 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 KLF13 SP3 MXD4 REST

Genomic Location for NUDT1 Gene

Chromosome:
7
Start:
2,242,222 bp from pter
End:
2,251,146 bp from pter
Size:
8,925 bases
Orientation:
Plus strand

Genomic View for NUDT1 Gene

Genes around NUDT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT1 Gene

Proteins for NUDT1 Gene

  • Protein details for NUDT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36639-8ODP_HUMAN
    Recommended name:
    7,8-dihydro-8-oxoguanine triphosphatase
    Protein Accession:
    P36639
    Secondary Accessions:
    • A4D205
    • Q6LES7
    • Q6P0Y6
    • Q7Z7N6
    • Q8IV95
    • Q9UBM0
    • Q9UBM9

    Protein attributes for NUDT1 Gene

    Size:
    197 amino acids
    Molecular mass:
    22520 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for NUDT1 Gene

    Alternative splice isoforms for NUDT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUDT1 Gene

Post-translational modifications for NUDT1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NUDT1 (NUDT1)
  • Santa Cruz Biotechnology (SCBT) Antibodies for NUDT1

No data available for DME Specific Peptides for NUDT1 Gene

Domains & Families for NUDT1 Gene

Gene Families for NUDT1 Gene

Graphical View of Domain Structure for InterPro Entry

P36639

UniProtKB/Swiss-Prot:

8ODP_HUMAN :
  • Contains 1 nudix hydrolase domain.
  • Belongs to the Nudix hydrolase family.
Domain:
  • Contains 1 nudix hydrolase domain.
Family:
  • Belongs to the Nudix hydrolase family.
genes like me logo Genes that share domains with NUDT1: view

Function for NUDT1 Gene

Molecular function for NUDT1 Gene

GENATLAS Biochemistry:
NUDIX (nucleoside diphosphate linked moiety X)-type motif 1,hydrolase,putative homolog of the mouse cleaning gene whose functions is to cleanse the cell of potentially deleterious endogenous metabolites and to modulate the accumulation of intermediates in biochemical pathways,presenting as seven types of mRNA produced by alternative transcription initiation and splicing
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=8.3 uM for 2-hydroxy-dATP (at 30 degrees Celsius and pH 8.0, PubMed:11139615) {ECO:0000269 PubMed:10373420, ECO:0000269 PubMed:11139615, ECO:0000269 PubMed:21787772}; KM=5.7 uM for 2-hydroxy-dATP (at 30 degrees Celsius and pH 7.2, PubMed:11139615) {ECO:0000269 PubMed:10373420, ECO:0000269 PubMed:11139615, ECO:0000269 PubMed:21787772}; KM=4.3 uM for 2-hydroxy-rATP (at 30 degrees Celsius and pH 8.0, PubMed:11139615) {ECO:0000269 PubMed:10373420, ECO:0000269 PubMed:11139615, ECO:0000269 PubMed:21787772}; KM=13.9 uM for 8-hydroxy-dATP (at 30 degrees Celsius and pH 8.0, PubMed:11139615) {ECO:0000269 PubMed:10373420, ECO:0000269 PubMed:11139615, ECO:0000269 PubMed:21787772}; KM=51.0 uM for 8-hydroxy-rATP (at 30 degrees Celsius and pH 8.0, PubMed:11139615) {ECO:0000269 PubMed:10373420, ECO:0000269 PubMed:11139615, ECO:0000269 PubMed:21787772}; KM=15.2 uM for 8-hydroxy-dGTP (at 30 degrees Celsius and pH 8.0, PubMed:11139615) {ECO:0000269 PubMed:10373420, ECO:0000269 PubMed:11139615, ECO:0000269 PubMed:21787772}; KM=12.8 uM for 8-hydroxy-dGTP (at 30 degrees Celsius and pH 7.2, PubMed:11139615) {ECO:0000269 PubMed:10373420, ECO:0000269 PubMed:11139615, ECO:0000269 PubMed:21787772}; KM=13.2 uM for 8-hydroxy-dGTP (at 22 degrees Celsius and pH 7.5, PubMed:21787772) {ECO:0000269 PubMed:10373420, ECO:0000269 PubMed:11139615, ECO:0000269 PubMed:21787772}; KM=55.0 uM for 8-hydroxy-rGTP (at 30 degrees Celsius and pH 8.0, PubMed:11139615) {ECO:0000269 PubMed:10373420, ECO:0000269 PubMed:11139615, ECO:0000269 PubMed:21787772}; KM=258 uM for dGTP (at 30 degrees Celsius and pH 8.0, PubMed:11139615) {ECO:0000269 PubMed:10373420, ECO:0000269 PubMed:11139615, ECO:0000269 PubMed:21787772}; Note=The kinetic constants are determined for the recombinant enzyme expressed in E.coli. 2-hydroxy-rATP shows the best catalytic efficiency.; pH dependence: Optimum pH is 7.8-8.2 with 8-hydroxy-dGTP as substrate, and 8.0- 8.5 with 2-hydroxy-dATP as substrate. {ECO:0000269 PubMed:10373420, ECO:0000269 PubMed:11139615, ECO:0000269 PubMed:21787772};
UniProtKB/Swiss-Prot CatalyticActivity:
8-oxo-dGTP + H(2)O = 8-oxo-dGMP + diphosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
2-hydroxy-dATP + H(2)O = 2-hydroxy-dAMP + diphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
2-hydroxy-dATPase activity is inhibited by 2-OH-dADP, 8-OH-dGDP and 8-OH-dGTP. 8-OH-dGTPase activity is inhibited by 8-OH-dGDP, 2-OH-dADP and 2-OH-dATP.
UniProtKB/Swiss-Prot Function:
Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.

Enzyme Numbers (IUBMB) for NUDT1 Gene

Gene Ontology (GO) - Molecular Function for NUDT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0003924 GTPase activity TAS 7713500
GO:0005515 protein binding IPI 25416956
GO:0008413 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity IDA 10373420
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with NUDT1: view
genes like me logo Genes that share phenotypes with NUDT1: view

Animal Models for NUDT1 Gene

MGI Knock Outs for NUDT1:

Animal Model Products

miRNA for NUDT1 Gene

miRTarBase miRNAs that target NUDT1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NUDT1 Gene

Localization for NUDT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDT1 Gene

Isoform p18: Cytoplasm. Mitochondrion matrix. Nucleus. Note=Mostly present in cytoplasm. Variant Met-124 has decreased efficiency in translocation to mitochondria.
Isoform p26: Cytoplasm. Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUDT1 Gene COMPARTMENTS Subcellular localization image for NUDT1 gene
Compartment Confidence
cytosol 5
extracellular 5
mitochondrion 5
nucleus 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for NUDT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005615 extracellular space IEA --
GO:0005634 nucleus IEA,IDA 12857738
GO:0005737 cytoplasm IEA,IDA 7782328
GO:0005739 mitochondrion IEA,IDA 12857738
genes like me logo Genes that share ontologies with NUDT1: view

Pathways & Interactions for NUDT1 Gene

genes like me logo Genes that share pathways with NUDT1: view

Pathways by source for NUDT1 Gene

1 Cell Signaling Technology pathway for NUDT1 Gene
1 BioSystems pathway for NUDT1 Gene

Gene Ontology (GO) - Biological Process for NUDT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006195 purine nucleotide catabolic process IDA 10608900
GO:0006203 dGTP catabolic process IDA 10373420
GO:0006281 DNA repair IC 10373420
GO:0006979 response to oxidative stress TAS 8226881
GO:0007568 aging IEA --
genes like me logo Genes that share ontologies with NUDT1: view

No data available for SIGNOR curated interactions for NUDT1 Gene

Drugs & Compounds for NUDT1 Gene

(12) Drugs for NUDT1 Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
(S)-Crizotinib Pharma Potent MTH1 inhibitor 0
SCH 51344 Pharma MTH1 inhibitor 0
TH287 Pharma MTH1 inhibitor 0
TH588 Pharma MTH1 inhibitor 0

(14) Additional Compounds for NUDT1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
8-Oxo-dgtp
  • 2'-Deoxy-7,8-dihydro-8-oxo-Guanosine 5'-(tetrahydrogen triphosphate)
  • 8-Hydroxy-2'-deoxyguanosine 5'-triphosphate
  • 8-Oxo-2'-deoxyguanosine 5'-triphosphate
  • 8-Oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate
  • 8-Oxo-deoxyguanosine triphosphate
139307-94-1
2-hydroxy-dAMP
2-hydroxy-dATP
8-Oxo-dGMP
  • 8-Oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate
  • 8OG
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8

(4) ApexBio Compounds for NUDT1 Gene

Compound Action Cas Number
(S)-Crizotinib Potent MTH1 inhibitor
SCH 51344 MTH1 inhibitor 171927-40-5
TH287 MTH1 inhibitor 1609960-30-6
TH588 MTH1 inhibitor 1609960-31-7
genes like me logo Genes that share compounds with NUDT1: view

Transcripts for NUDT1 Gene

Unigene Clusters for NUDT1 Gene

Nudix (nucleoside diphosphate linked moiety X)-type motif 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - - - - -
SP2: - - - -
SP3: - - - - - - -
SP4: - -
SP5: -
SP6: -
SP7: -

Relevant External Links for NUDT1 Gene

GeneLoc Exon Structure for
NUDT1
ECgene alternative splicing isoforms for
NUDT1

Expression for NUDT1 Gene

mRNA expression in normal human tissues for NUDT1 Gene

mRNA differential expression in normal tissues according to GTEx for NUDT1 Gene

This gene is overexpressed in Testis (x4.2).

Protein differential expression in normal tissues from HIPED for NUDT1 Gene

This gene is overexpressed in Bone (41.0) and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NUDT1 Gene



NURSA nuclear receptor signaling pathways regulating expression of NUDT1 Gene:

NUDT1

SOURCE GeneReport for Unigene cluster for NUDT1 Gene:

Hs.534331

mRNA Expression by UniProt/SwissProt for NUDT1 Gene:

P36639-8ODP_HUMAN
Tissue specificity: Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes.
genes like me logo Genes that share expression patterns with NUDT1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for NUDT1 Gene

Orthologs for NUDT1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NUDT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUDT1 34 35
  • 99.26 (n)
cow
(Bos Taurus)
Mammalia NUDT1 34 35
  • 87.61 (n)
dog
(Canis familiaris)
Mammalia NUDT1 34 35
  • 86.75 (n)
rat
(Rattus norvegicus)
Mammalia Nudt1 34
  • 82.47 (n)
mouse
(Mus musculus)
Mammalia Nudt1 34 16 35
  • 81.08 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 80 (a)
OneToMany
-- 35
  • 77 (a)
OneToMany
-- 35
  • 77 (a)
OneToMany
-- 35
  • 73 (a)
OneToMany
-- 35
  • 71 (a)
OneToMany
-- 35
  • 70 (a)
OneToMany
-- 35
  • 68 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia NUDT1 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUDT1 34 35
  • 71.58 (n)
lizard
(Anolis carolinensis)
Reptilia NUDT1 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nudt1 34
  • 64.96 (n)
zebrafish
(Danio rerio)
Actinopterygii nudt1 34 35
  • 66.88 (n)
wufb40g09 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3478 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 47 (a)
OneToOne
Species where no ortholog for NUDT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUDT1 Gene

ENSEMBL:
Gene Tree for NUDT1 (if available)
TreeFam:
Gene Tree for NUDT1 (if available)

Paralogs for NUDT1 Gene

No data available for Paralogs for NUDT1 Gene

Variants for NUDT1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT1 Gene

8ODP_HUMAN-P36639
A polymorphism between Met-1 and Met-19 removes a stop codon before the initiation codon for isoform p22 and gives rise to the production of isoform p26. The allele frequency of isoform p26 is about 20%.

Sequence variations from dbSNP and Humsavar for NUDT1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10230814 -- 2,250,693(+) gacct(C/T)gtgat intron-variant
rs10230822 -- 2,250,737(+) ACAGG(C/T)GTGAG intron-variant
rs10230928 -- 2,250,798(+) TGCAC(C/T)TCAGT intron-variant
rs10231313 -- 2,251,111(+) ATTAA(C/G)TGGAT utr-variant-3-prime
rs10232413 -- 2,246,712(+) TACAG(C/T)GGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUDT1 Gene

Variant ID Type Subtype PubMed ID
esv2761136 CNV gain 21179565
nsv1018563 CNV gain 25217958
nsv1021173 CNV loss 25217958
nsv1021310 CNV loss 25217958
nsv830886 CNV loss 17160897

Variation tolerance for NUDT1 Gene

Residual Variation Intolerance Score: 68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.66; 45.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUDT1 Gene

Human Gene Mutation Database (HGMD)
NUDT1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUDT1

Disorders for NUDT1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NUDT1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
myxosarcoma
attenuated familial adenomatous polyposis
  • aapc
gastric diffuse adenocarcinoma
  • adenocarcinoma of linitis plastica type
- elite association - COSMIC cancer census association via MalaCards
Search NUDT1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NUDT1

Genetic Association Database (GAD)
NUDT1
Human Genome Epidemiology (HuGE) Navigator
NUDT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUDT1
genes like me logo Genes that share disorders with NUDT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUDT1 Gene

Publications for NUDT1 Gene

  1. Association of polymorphisms in the MTH1 gene with small cell lung carcinoma risk. (PMID: 16774934) Kohno T. … Yokota J. (Carcinogenesis 2006) 3 4 22 46 64
  2. Association study of human MTH1 gene polymorphisms with type 1 diabetes mellitus. (PMID: 15516784) Miyako K. … Hara T. (Endocr. J. 2004) 3 4 22 46 64
  3. Cloning and expression of cDNA for a human enzyme that hydrolyzes 8- oxo-dGTP, a mutagenic substrate for DNA synthesis. (PMID: 8226881) Sakumi K. … Sekiguchi M. (J. Biol. Chem. 1993) 2 3 4 22 64
  4. Association study of human MTH1 Ile45Thr polymorphism with sporadic Parkinson's disease. (PMID: 17917452) Jiang G. … Zhu C. (Eur. Neurol. 2008) 3 22 46 64
  5. Analysis of the base excision repair genes MTH1, OGG1 and MUTYH in patients with squamous oral carcinomas. (PMID: 17207658) GAPrgens H. … Eckelt U. (Oral Oncol. 2007) 3 22 46 64

Products for NUDT1 Gene

Sources for NUDT1 Gene

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