NUDCD3 Gene
protein-coding GIFtS: 49
GCID: GC07M044421
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|
NudC domain containing 3
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Aliases
for NUDCD3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| NudC Domain Containing 31 2 | | KIAA10681 3 | | NudCL2 | | NudC Domain-Containing Protein 32 | | NudC-Like Protein2 |
Export aliases for NUDCD3 gene to outside databasesPrevious GC identifers: GC07M044196 GC07M044389 |
Summaries
for NUDCD3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NUDCD3:
The product of this gene functions to maintain the stability of dynein intermediate chain. Depletion of this geneproduct results in aggregation and degradation of dynein intermediate chain, mislocalization of the dynein complexfrom kinetochores, spindle microtubules, and spindle poles, and loss of gamma-tubulin from spindle poles. The proteinlocalizes to the Golgi apparatus during interphase, and levels of the protein increase after the G1/S transition.(provided by RefSeq, Jul 2008)
Gene Wiki entry for NUDCD3
|
Genomic Views
for NUDCD3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NUDCD3 gene promoter:
GATA-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NUDCD3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUDCD3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7p13-p12 Ensembl cytogenetic band: 7p13 HGNC cytogenetic band: 7p13-p12NUDCD3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M044421: view genomic region
(about GC identifiers)
Start:
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44,421,965 bp from pter |
End:
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44,530,479 bp from pter |
Size:
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108,515 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 44,461,485-44,569,909 |
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Proteins
for NUDCD3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NUDC3_HUMAN, Q8IVD9 (See
protein sequence)Recommended Name: NudC domain-containing protein 3 Size: 361 amino acids; 40822 Da
Sequence caution: Sequence=AAH03691.1; Type=Erroneous initiation; Sequence=AAQ96892.1; Type=Erroneous gene modelprediction; Sequence=BAB14855.1; Type=Erroneous initiation;
1 PDB 3D structure from  and Proteopedia  for NUDCD3:1WGV (3D)
Secondary accessions: Q9BTI3 Q9H7W9 Q9UPT4Explore the universe of human proteins at neXtProt for NUDCD3: NX_Q8IVD9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IVD9
NUDCD3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_056147.2
ENSEMBL proteins: ENSP00000347626
Human Recombinant Protein Products:
NUDCD3 Antibody Products:
Assay Products for NUDCD3: |
Protein
Domains /
Families
for NUDCD3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NUDCD3 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IVD9ProtoNet protein and cluster: Q8IVD9 UniProtKB/Swiss-Prot: NUDC3_HUMAN, Q8IVD9Similarity: Contains 1 CS domain |
Function
for NUDCD3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUDCD3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUDCD3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for NUDCD3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUDCD3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDCD3 |
2 GenomeRNAi human phenotypes for NUDCD3:
|
Pathways & Interactions
for NUDCD3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NUDCD3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/7 Interacting proteins for NUDCD3 (Q8IVD93 ENSP000003476264) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
|
Drugs & Compounds
for NUDCD3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NUDCD3
Search CenterWatch for drugs/clinical trials and news about NUDCD3 / NUDC3
|
Transcripts
for NUDCD3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NUDCD3 gene: NM_015332.3 Unigene Cluster for NUDCD3: NudC domain containing 3 Hs.488171 [show with all ESTs]Unigene Representative Sequence: NM_01533211 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000355451(uc010kye.3 uc003tkz.3) ENST00000487118 ENST00000460110
ENST00000475952 ENST00000338427 ENST00000493613 ENST00000472246 ENST00000464812
ENST00000478769 ENST00000480209 ENST00000497978
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUDCD3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUDCD3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NUDCD3 (NM_015332) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NUDCD3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUDCD3 |
Additional cDNA sequence: AB028991.1 AK024226.1 AK025555.1 AK026126.1 AK124729.1 AK127163.1 AK307613.1 BC003691.2 BC011673.2 BC017657.1 BC035014.2 EU350932.1 24/28 DOTS entries (see all 28): DT.97856954 DT.101963232 DT.119095 DT.97857405 DT.101986381 DT.92456487 DT.100826490 DT.91655672 DT.121110242 DT.121110295 DT.100800250 DT.100826492 DT.121110286 DT.70103948 DT.75165975 DT.100733594 DT.100826478 DT.121110368 DT.86845162 DT.92456489 DT.92456491 DT.92456495 DT.95158884 DT.95158885
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for NUDCD3 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b |
|---|
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| SP1: | | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | - | | | | - | | - | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NUDCD3
|
Expression
for NUDCD3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NUDCD3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCAGGAACAG
About this image
See NUDCD3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NUDCD3
SOURCE GeneReport for Unigene cluster: Hs.488171
SABiosciences Custom PCR Arrays for NUDCD3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUDCD3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NUDCD3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUDCD3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUDCD3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDCD3 |
Orthologs
for NUDCD3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for NUDCD3 gene from 5/21 species (see all 21) About this table
ENSEMBL Gene Tree for NUDCD3 (if available)
TreeFam Gene Tree for NUDCD3 (if available) |
Paralogs
for NUDCD3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NUDCD3 gene
- NUDC2
2 SIMAP similar genes for NUDCD3 using alignment to 1 protein entry: NUDC3_HUMAN:KIAA1068 NUDC
NUDCD3 for paralogs About GeneDecksing
|
Genomic Variants
for NUDCD3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NUDCD3 (44421965 - 44530479 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for NUDCD3
1 Indel: 11300 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for NUDCD3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NUDCD3 for disorders About GeneDecksing
OMIM gene information: 610296
OMIM disorders: --
3  diseases for NUDCD3: About MalaCardsprader-willi syndrome malignant fibroxanthoma malaria
Human Genome Epidemiology (HuGE) Navigator: NUDCD3 (1 document)
Export disorders for NUDCD3 gene to outside databases
|
Publications
for NUDCD3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NUDCD3 gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with NUDCD3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R....Ohara O. (1999)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
|
External Searches for NUDCD3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NUDCD3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NUDCD3 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing NUDCD3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NUDCD3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NUDCD3 gene:
Search GeneIP for patents involving NUDCD3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NUDCD3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NUDCD3 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NUDCD3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUDCD3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUDCD3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUDCD3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUDCD3 |
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 | | | NUDCD3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDCD3 |
|  |  |  | | | | ThermoFisher Antibodies for NUDCD3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUDCD3 |
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