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Aliases for NUDCD3 Gene

Aliases for NUDCD3 Gene

  • NudC Domain Containing 3 2 3 5
  • NudC-Like Protein 3
  • KIAA1068 4
  • NudCL 3

External Ids for NUDCD3 Gene

Previous GeneCards Identifiers for NUDCD3 Gene

  • GC07M044196
  • GC07M044389

Summaries for NUDCD3 Gene

Entrez Gene Summary for NUDCD3 Gene

  • The product of this gene functions to maintain the stability of dynein intermediate chain. Depletion of this gene product results in aggregation and degradation of dynein intermediate chain, mislocalization of the dynein complex from kinetochores, spindle microtubules, and spindle poles, and loss of gamma-tubulin from spindle poles. The protein localizes to the Golgi apparatus during interphase, and levels of the protein increase after the G1/S transition. [provided by RefSeq, Jul 2008]

GeneCards Summary for NUDCD3 Gene

NUDCD3 (NudC Domain Containing 3) is a Protein Coding gene. An important paralog of this gene is NUDC.

Gene Wiki entry for NUDCD3 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDCD3 Gene

Genomics for NUDCD3 Gene

Regulatory Elements for NUDCD3 Gene

Enhancers for NUDCD3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NUDCD3 on UCSC Golden Path with GeneCards custom track

Promoters for NUDCD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NUDCD3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the NUDCD3 gene promoter:

Genomic Location for NUDCD3 Gene

Chromosome:
7
Start:
44,379,121 bp from pter
End:
44,490,880 bp from pter
Size:
111,760 bases
Orientation:
Minus strand

Genomic View for NUDCD3 Gene

Genes around NUDCD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDCD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDCD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDCD3 Gene

Proteins for NUDCD3 Gene

  • Protein details for NUDCD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVD9-NUDC3_HUMAN
    Recommended name:
    NudC domain-containing protein 3
    Protein Accession:
    Q8IVD9
    Secondary Accessions:
    • Q9BTI3
    • Q9H7W9
    • Q9UPT4

    Protein attributes for NUDCD3 Gene

    Size:
    361 amino acids
    Molecular mass:
    40822 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH03691.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ96892.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAB14855.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NUDCD3 Gene

neXtProt entry for NUDCD3 Gene

Proteomics data for NUDCD3 Gene at MOPED

Post-translational modifications for NUDCD3 Gene

  • Ubiquitination at Lys 177
  • Modification sites at PhosphoSitePlus

Other Protein References for NUDCD3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NUDCD3 Gene

Domains & Families for NUDCD3 Gene

Protein Domains for NUDCD3 Gene

Suggested Antigen Peptide Sequences for NUDCD3 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IVD9

UniProtKB/Swiss-Prot:

NUDC3_HUMAN :
  • Contains 1 CS domain.
Domain:
  • Contains 1 CS domain.
genes like me logo Genes that share domains with NUDCD3: view

No data available for Gene Families for NUDCD3 Gene

Function for NUDCD3 Gene

Phenotypes for NUDCD3 Gene

genes like me logo Genes that share phenotypes with NUDCD3: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUDCD3 Gene

Localization for NUDCD3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUDCD3 Gene COMPARTMENTS Subcellular localization image for NUDCD3 gene
Compartment Confidence
cytosol 4
nucleus 2
plasma membrane 2
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NUDCD3 Gene

Pathways & Interactions for NUDCD3 Gene

SuperPathways for NUDCD3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NUDCD3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NUDCD3 Gene

Drugs & Compounds for NUDCD3 Gene

No Compound Related Data Available

Transcripts for NUDCD3 Gene

mRNA/cDNA for NUDCD3 Gene

(3) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NUDCD3 Gene

NudC domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUDCD3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: -
SP2: - - - -
SP3:

Relevant External Links for NUDCD3 Gene

GeneLoc Exon Structure for
NUDCD3
ECgene alternative splicing isoforms for
NUDCD3

Expression for NUDCD3 Gene

mRNA expression in normal human tissues for NUDCD3 Gene

Protein differential expression in normal tissues from HIPED for NUDCD3 Gene

This gene is overexpressed in Testis (17.7) and Peripheral blood mononuclear cells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUDCD3 Gene



SOURCE GeneReport for Unigene cluster for NUDCD3 Gene Hs.488171

genes like me logo Genes that share expression patterns with NUDCD3: view

Protein tissue co-expression partners for NUDCD3 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NUDCD3 Gene

Orthologs for NUDCD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUDCD3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NUDCD3 35
  • 86.42 (n)
  • 89.33 (a)
NUDCD3 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nudcd3 35
  • 86.11 (n)
  • 88.06 (a)
Nudcd3 16
Nudcd3 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NUDCD3 35
  • 99.45 (n)
  • 99.45 (a)
NUDCD3 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 83 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia NUDCD3 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUDCD3 36
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUDCD3 35
  • 73.86 (n)
  • 75 (a)
NUDCD3 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUDCD3 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nudcd3 35
  • 66.57 (n)
  • 66.86 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
nudcd3 35
  • 61.28 (n)
  • 58.98 (a)
nudcd3 36
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG31251 35
  • 48.91 (n)
  • 35.4 (a)
CG31251 36
  • 30 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToOne
Species with no ortholog for NUDCD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUDCD3 Gene

ENSEMBL:
Gene Tree for NUDCD3 (if available)
TreeFam:
Gene Tree for NUDCD3 (if available)

Paralogs for NUDCD3 Gene

Paralogs for NUDCD3 Gene

(2) SIMAP similar genes for NUDCD3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NUDCD3: view

Variants for NUDCD3 Gene

Sequence variations from dbSNP and Humsavar for NUDCD3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs11550029 - 44,404,523(-) GGGAG(C/T)GCGTC reference, missense
rs307007 - 44,490,594(+) CCCTG(C/G/T)CTCCA reference, missense
rs6949216 -- 44,461,274(+) tggga(C/T)tgcaa intron-variant
rs1043079 -- 44,385,030(-) CAGAA(A/G)AGAGT intron-variant, utr-variant-3-prime
rs1043084 -- 44,384,654(-) AAGAG(A/G)GCCTA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NUDCD3 Gene

Variant ID Type Subtype PubMed ID
nsv830984 CNV Gain 17160897
nsv526063 CNV Loss 19592680
esv33931 CNV Loss 17666407
esv2734323 CNV Deletion 23290073
esv2675906 CNV Deletion 23128226

Variation tolerance for NUDCD3 Gene

Residual Variation Intolerance Score: 68.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.71; 83.05% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NUDCD3 Gene

Disorders for NUDCD3 Gene

Relevant External Links for NUDCD3

Genetic Association Database (GAD)
NUDCD3
Human Genome Epidemiology (HuGE) Navigator
NUDCD3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUDCD3

No disorders were found for NUDCD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUDCD3 Gene

Publications for NUDCD3 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. A mammalian NudC-like protein essential for dynein stability and cell viability. (PMID: 16754861) Zhou T. … Erikson R.L. (Proc. Natl. Acad. Sci. U.S.A. 2006) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3

Products for NUDCD3 Gene

Sources for NUDCD3 Gene

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