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Aliases for NUDCD3 Gene

Aliases for NUDCD3 Gene

  • NudC Domain Containing 3 2 3
  • KIAA1068 4 6
  • NudCL 3 6
  • NudC Domain-Containing Protein 3 3
  • NudC-Like Protein 3

External Ids for NUDCD3 Gene

Previous GeneCards Identifiers for NUDCD3 Gene

  • GC07M044196
  • GC07M044389

Summaries for NUDCD3 Gene

Entrez Gene Summary for NUDCD3 Gene

  • The product of this gene functions to maintain the stability of dynein intermediate chain. Depletion of this gene product results in aggregation and degradation of dynein intermediate chain, mislocalization of the dynein complex from kinetochores, spindle microtubules, and spindle poles, and loss of gamma-tubulin from spindle poles. The protein localizes to the Golgi apparatus during interphase, and levels of the protein increase after the G1/S transition. [provided by RefSeq, Jul 2008]

GeneCards Summary for NUDCD3 Gene

NUDCD3 (NudC Domain Containing 3) is a Protein Coding gene. An important paralog of this gene is NUDC.

Gene Wiki entry for NUDCD3 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDCD3 Gene

Genomics for NUDCD3 Gene

Regulatory Elements for NUDCD3 Gene

Transcription factor binding sites by QIAGEN in the NUDCD3 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NUDCD3 Gene

44,379,121 bp from pter
44,490,880 bp from pter
111,760 bases
Minus strand

Genomic View for NUDCD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUDCD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDCD3 Gene

Proteins for NUDCD3 Gene

  • Protein details for NUDCD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NudC domain-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • Q9BTI3
    • Q9H7W9
    • Q9UPT4

    Protein attributes for NUDCD3 Gene

    361 amino acids
    Molecular mass:
    40822 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH03691.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ96892.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAB14855.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NUDCD3 Gene

neXtProt entry for NUDCD3 Gene

Proteomics data for NUDCD3 Gene at MOPED

Post-translational modifications for NUDCD3 Gene

  • Ubiquitination at Lys177
  • Modification sites at PhosphoSitePlus

Other Protein References for NUDCD3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NUDCD3 Gene

Domains for NUDCD3 Gene

Protein Domains for NUDCD3 Gene

Suggested Antigen Peptide Sequences for NUDCD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CS domain.
  • Contains 1 CS domain.
genes like me logo Genes that share domains with NUDCD3: view

No data available for Gene Families for NUDCD3 Gene

Function for NUDCD3 Gene

Gene Ontology (GO) - Molecular Function for NUDCD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20562859
genes like me logo Genes that share ontologies with NUDCD3: view

Phenotypes for NUDCD3 Gene

GenomeRNAi human phenotypes for NUDCD3:
genes like me logo Genes that share phenotypes with NUDCD3: view

Animal Model Products

miRNA for NUDCD3 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NUDCD3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for NUDCD3 Gene

Localization for NUDCD3 Gene

Subcellular locations from

Jensen Localization Image for NUDCD3 Gene COMPARTMENTS Subcellular localization image for NUDCD3 gene
Compartment Confidence
cytosol 3
nucleus 2
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NUDCD3 Gene

Pathways for NUDCD3 Gene

SuperPathways for NUDCD3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NUDCD3 Gene


No data available for Pathways by source for NUDCD3 Gene

Transcripts for NUDCD3 Gene

mRNA/cDNA for NUDCD3 Gene

(3) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NUDCD3 Gene

NudC domain containing 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NUDCD3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUDCD3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: -
SP2: - - - -

Relevant External Links for NUDCD3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NUDCD3 Gene

mRNA expression in normal human tissues for NUDCD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for NUDCD3 Gene

This gene is overexpressed in Testis (17.7) and Peripheral blood mononuclear cells (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUDCD3 Gene

SOURCE GeneReport for Unigene cluster for NUDCD3 Gene Hs.488171

genes like me logo Genes that share expressions with NUDCD3: view

Expression partners for NUDCD3 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NUDCD3 Gene

Orthologs for NUDCD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUDCD3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NUDCD3 35
  • 86.42 (n)
  • 89.33 (a)
  • 87 (a)
(Mus musculus)
Mammalia Nudcd3 35
  • 86.11 (n)
  • 88.06 (a)
Nudcd3 16
Nudcd3 36
  • 85 (a)
(Pan troglodytes)
Mammalia NUDCD3 35
  • 99.45 (n)
  • 99.45 (a)
  • 99 (a)
(Canis familiaris)
Mammalia -- 36
  • 83 (a)
-- 36
  • 61 (a)
(Monodelphis domestica)
Mammalia NUDCD3 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia NUDCD3 36
  • 56 (a)
(Gallus gallus)
Aves NUDCD3 35
  • 73.86 (n)
  • 75 (a)
  • 72 (a)
(Anolis carolinensis)
Reptilia NUDCD3 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nudcd3 35
  • 66.57 (n)
  • 66.86 (a)
(Danio rerio)
Actinopterygii -- 35
nudcd3 35
  • 61.28 (n)
  • 58.98 (a)
nudcd3 36
  • 57 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31251 35
  • 48.91 (n)
  • 35.4 (a)
CG31251 36
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
Species with no ortholog for NUDCD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUDCD3 Gene

Gene Tree for NUDCD3 (if available)
Gene Tree for NUDCD3 (if available)

Paralogs for NUDCD3 Gene

Paralogs for NUDCD3 Gene

(2) SIMAP similar genes for NUDCD3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NUDCD3: view

Variants for NUDCD3 Gene

Sequence variations from dbSNP and Humsavar for NUDCD3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs12713 -- 44,384,122(+) AGGTG(C/T)AGGGC utr-variant-3-prime
rs167400 -- 44,488,354(-) tcttt(C/T)ttttt intron-variant
rs170069 -- 44,473,535(-) CTGGA(A/G)TGTGC intron-variant
rs307004 -- 44,492,035(-) ggtct(C/T)gaact upstream-variant-2KB
rs307005 -- 44,491,944(-) tagta(A/G)gctca upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NUDCD3 Gene

Variant ID Type Subtype PubMed ID
nsv830984 CNV Gain 17160897
nsv526063 CNV Loss 19592680
esv33931 CNV Loss 17666407
esv2734323 CNV Deletion 23290073
esv2675906 CNV Deletion 23128226

Relevant External Links for NUDCD3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDCD3 Gene

Disorders for NUDCD3 Gene

Relevant External Links for NUDCD3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for NUDCD3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for NUDCD3 Gene

Publications for NUDCD3 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 3 4
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for NUDCD3 Gene

Sources for NUDCD3 Gene

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