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Aliases for NUDCD3 Gene

Aliases for NUDCD3 Gene

  • NudC Domain Containing 3 2 3 5
  • NudC Domain-Containing Protein 3 3
  • NudC-Like Protein 3
  • KIAA1068 4
  • NudCL 3

External Ids for NUDCD3 Gene

Previous GeneCards Identifiers for NUDCD3 Gene

  • GC07M044196
  • GC07M044389

Summaries for NUDCD3 Gene

Entrez Gene Summary for NUDCD3 Gene

  • The product of this gene functions to maintain the stability of dynein intermediate chain. Depletion of this gene product results in aggregation and degradation of dynein intermediate chain, mislocalization of the dynein complex from kinetochores, spindle microtubules, and spindle poles, and loss of gamma-tubulin from spindle poles. The protein localizes to the Golgi apparatus during interphase, and levels of the protein increase after the G1/S transition. [provided by RefSeq, Jul 2008]

GeneCards Summary for NUDCD3 Gene

NUDCD3 (NudC Domain Containing 3) is a Protein Coding gene. An important paralog of this gene is NUDC.

Gene Wiki entry for NUDCD3 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDCD3 Gene

Genomics for NUDCD3 Gene

Regulatory Elements for NUDCD3 Gene

Enhancers for NUDCD3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F044460 1.1 Ensembl ENCODE 42 +29.8 29837 2.1 MXI1 USF1 TBL1XR1 MAX ZNF175 EBF1 ZBTB40 PRDM10 NFE2 CREM NUDCD3 POLD2 AEBP1 MIR4649 RPL32P18 PIR50224
GH07F044437 0.9 ENCODE 41.5 +52.2 52217 2.6 PKNOX1 ATF1 ARNT KLF17 SIN3A ZNF2 RAD21 ZNF335 ZNF366 SCRT2 NUDCD3 RNU6-1097P NPC1L1 CAMK2B RPL32P18 PIR50224
GH07F044488 1.2 ENCODE 30.7 +0.6 590 2.6 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 NUDCD3 MIR4649 TBRG4 DDX56 SNORA5B GC07M044472 GC07M044473
GH07F044472 1.2 Ensembl ENCODE 30.3 +17.1 17064 2.3 ELF3 TBP PKNOX1 ATF1 MLX ARID4B FEZF1 DMAP1 THRB ZSCAN9 NUDCD3 RNU6-1097P CAMK2B AEBP1 MIR4649 STK17A GC07M044472 GC07M044473
GH07F044377 1 Ensembl ENCODE 29.9 +109.7 109682 7.3 CTCF JUN RARA CTBP1 ZFHX2 POLR2A EED FOS NR2F6 MAFK NUDCD3 CAMK2B NPC1L1 PIR57100 PIR62286
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NUDCD3 on UCSC Golden Path with GeneCards custom track

Promoters for NUDCD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000625719 480 2400 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2

Transcription factor binding sites by QIAGEN in the NUDCD3 gene promoter:

Genomic Location for NUDCD3 Gene

Chromosome:
7
Start:
44,379,121 bp from pter
End:
44,490,880 bp from pter
Size:
111,760 bases
Orientation:
Minus strand

Genomic View for NUDCD3 Gene

Genes around NUDCD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDCD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDCD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDCD3 Gene

Proteins for NUDCD3 Gene

  • Protein details for NUDCD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVD9-NUDC3_HUMAN
    Recommended name:
    NudC domain-containing protein 3
    Protein Accession:
    Q8IVD9
    Secondary Accessions:
    • Q9BTI3
    • Q9H7W9
    • Q9UPT4

    Protein attributes for NUDCD3 Gene

    Size:
    361 amino acids
    Molecular mass:
    40822 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH03691.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ96892.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAB14855.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NUDCD3 Gene

neXtProt entry for NUDCD3 Gene

Post-translational modifications for NUDCD3 Gene

  • Ubiquitination at Lys 177
  • Modification sites at PhosphoSitePlus

Other Protein References for NUDCD3 Gene

No data available for DME Specific Peptides for NUDCD3 Gene

Domains & Families for NUDCD3 Gene

Gene Families for NUDCD3 Gene

Protein Domains for NUDCD3 Gene

Suggested Antigen Peptide Sequences for NUDCD3 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IVD9

UniProtKB/Swiss-Prot:

NUDC3_HUMAN :
  • Contains 1 CS domain.
Domain:
  • Contains 1 CS domain.
genes like me logo Genes that share domains with NUDCD3: view

Function for NUDCD3 Gene

Gene Ontology (GO) - Molecular Function for NUDCD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20562859
GO:0051082 unfolded protein binding IBA --
genes like me logo Genes that share ontologies with NUDCD3: view
genes like me logo Genes that share phenotypes with NUDCD3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUDCD3 Gene

Localization for NUDCD3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUDCD3 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
plasma membrane 2
nucleus 2

Gene Ontology (GO) - Cellular Components for NUDCD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with NUDCD3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NUDCD3 Gene

Pathways & Interactions for NUDCD3 Gene

SuperPathways for NUDCD3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NUDCD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IBA --
GO:0007275 multicellular organism development IBA --
genes like me logo Genes that share ontologies with NUDCD3: view

No data available for Pathways by source and SIGNOR curated interactions for NUDCD3 Gene

Transcripts for NUDCD3 Gene

mRNA/cDNA for NUDCD3 Gene

(5) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NUDCD3 Gene

NudC domain containing 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUDCD3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: -
SP2: - - - -
SP3:

Relevant External Links for NUDCD3 Gene

GeneLoc Exon Structure for
NUDCD3
ECgene alternative splicing isoforms for
NUDCD3

Expression for NUDCD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NUDCD3 Gene

Protein differential expression in normal tissues from HIPED for NUDCD3 Gene

This gene is overexpressed in Testis (17.7) and Peripheral blood mononuclear cells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NUDCD3 Gene



Protein tissue co-expression partners for NUDCD3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NUDCD3 Gene:

NUDCD3

SOURCE GeneReport for Unigene cluster for NUDCD3 Gene:

Hs.488171
genes like me logo Genes that share expression patterns with NUDCD3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NUDCD3 Gene

Orthologs for NUDCD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUDCD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUDCD3 34 35
  • 99.45 (n)
cow
(Bos Taurus)
Mammalia NUDCD3 34 35
  • 86.42 (n)
mouse
(Mus musculus)
Mammalia Nudcd3 34 16 35
  • 86.11 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 83 (a)
OneToMany
-- 35
  • 61 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia NUDCD3 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUDCD3 35
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUDCD3 34 35
  • 73.86 (n)
lizard
(Anolis carolinensis)
Reptilia NUDCD3 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nudcd3 34
  • 66.57 (n)
zebrafish
(Danio rerio)
Actinopterygii nudcd3 34 35
  • 61.28 (n)
-- 34
fruit fly
(Drosophila melanogaster)
Insecta CG31251 34 35
  • 48.91 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
OneToOne
Species where no ortholog for NUDCD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUDCD3 Gene

ENSEMBL:
Gene Tree for NUDCD3 (if available)
TreeFam:
Gene Tree for NUDCD3 (if available)

Paralogs for NUDCD3 Gene

Paralogs for NUDCD3 Gene

(2) SIMAP similar genes for NUDCD3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NUDCD3: view

Variants for NUDCD3 Gene

Sequence variations from dbSNP and Humsavar for NUDCD3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10155867 -- 44,457,650(+) taata(C/T)aggac intron-variant
rs10155870 -- 44,457,662(+) tgtat(C/G)tagac intron-variant
rs10216006 -- 44,421,655(+) gagca(C/G)ccaga intron-variant
rs10216103 -- 44,423,011(+) taatc(C/G)atcac intron-variant
rs10225003 -- 44,430,481(+) CTTCT(C/T)TTCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUDCD3 Gene

Variant ID Type Subtype PubMed ID
nsv981461 CNV duplication 23825009
nsv830984 CNV gain 17160897
nsv606806 CNV loss 21841781
nsv526063 CNV loss 19592680
esv3613010 CNV loss 21293372
esv3613009 CNV loss 21293372
esv33931 CNV loss 17666407
esv2734323 CNV deletion 23290073
esv2675906 CNV deletion 23128226

Variation tolerance for NUDCD3 Gene

Residual Variation Intolerance Score: 68.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.71; 83.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUDCD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUDCD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDCD3 Gene

Disorders for NUDCD3 Gene

Relevant External Links for NUDCD3

Genetic Association Database (GAD)
NUDCD3
Human Genome Epidemiology (HuGE) Navigator
NUDCD3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUDCD3

No disorders were found for NUDCD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUDCD3 Gene

Publications for NUDCD3 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. A mammalian NudC-like protein essential for dynein stability and cell viability. (PMID: 16754861) Zhou T. … Erikson R.L. (Proc. Natl. Acad. Sci. U.S.A. 2006) 2 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64

Products for NUDCD3 Gene

Sources for NUDCD3 Gene

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