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Aliases for NUDCD2 Gene

Aliases for NUDCD2 Gene

  • NudC Domain Containing 2 2 3

External Ids for NUDCD2 Gene

Previous GeneCards Identifiers for NUDCD2 Gene

  • GC05M162800
  • GC05M157980
  • GC05M162880

Summaries for NUDCD2 Gene

GeneCards Summary for NUDCD2 Gene

NUDCD2 (NudC Domain Containing 2) is a Protein Coding gene.

UniProtKB/Swiss-Prot for NUDCD2 Gene

  • May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone.

Gene Wiki entry for NUDCD2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDCD2 Gene

Genomics for NUDCD2 Gene

Regulatory Elements for NUDCD2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NUDCD2 Gene

Start:
163,446,526 bp from pter
End:
163,460,140 bp from pter
Size:
13,615 bases
Orientation:
Minus strand

Genomic View for NUDCD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUDCD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDCD2 Gene

Proteins for NUDCD2 Gene

  • Protein details for NUDCD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVJ2-NUDC2_HUMAN
    Recommended name:
    NudC domain-containing protein 2
    Protein Accession:
    Q8WVJ2
    Secondary Accessions:
    • B2R4V0

    Protein attributes for NUDCD2 Gene

    Size:
    157 amino acids
    Molecular mass:
    17676 Da
    Quaternary structure:
    • Interacts with LIS1.

neXtProt entry for NUDCD2 Gene

Proteomics data for NUDCD2 Gene at MOPED

Post-translational modifications for NUDCD2 Gene

  • Ubiquitination at Lys65, Lys129, and Lys147
  • Modification sites at PhosphoSitePlus

Other Protein References for NUDCD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NUDCD2 Gene

Domains for NUDCD2 Gene

Protein Domains for NUDCD2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NUDCD2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WVJ2

UniProtKB/Swiss-Prot:

NUDC2_HUMAN :
  • Q8WVJ2
Domain:
  • Contains 1 CS domain.
genes like me logo Genes that share domains with NUDCD2: view

No data available for Gene Families for NUDCD2 Gene

Function for NUDCD2 Gene

Molecular function for NUDCD2 Gene

UniProtKB/Swiss-Prot Function: May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone.

Gene Ontology (GO) - Molecular Function for NUDCD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23455924
genes like me logo Genes that share ontologies with NUDCD2: view

Animal Model Products

CRISPR Products

miRNA for NUDCD2 Gene

miRTarBase miRNAs that target NUDCD2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NUDCD2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NUDCD2 Gene

Localization for NUDCD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDCD2 Gene

Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Associates with centrosomes in interphase and to spindle poles and kinetochores during mitosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUDCD2 Gene COMPARTMENTS Subcellular localization image for NUDCD2 gene
Compartment Confidence
cytoskeleton 5
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for NUDCD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0000922 spindle pole IEA --
GO:0005622 intracellular IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with NUDCD2: view

Pathways for NUDCD2 Gene

SuperPathways for NUDCD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NUDCD2 Gene

None

No data available for Pathways by source for NUDCD2 Gene

Transcripts for NUDCD2 Gene

mRNA/cDNA for NUDCD2 Gene

Unigene Clusters for NUDCD2 Gene

NudC domain containing 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NUDCD2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUDCD2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5
SP1: - -
SP2: -
SP3:

Relevant External Links for NUDCD2 Gene

GeneLoc Exon Structure for
NUDCD2
ECgene alternative splicing isoforms for
NUDCD2

Expression for NUDCD2 Gene

mRNA expression in normal human tissues for NUDCD2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUDCD2 Gene

SOURCE GeneReport for Unigene cluster for NUDCD2 Gene Hs.140443

genes like me logo Genes that share expressions with NUDCD2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NUDCD2 Gene

Orthologs for NUDCD2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NUDCD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUDCD2 35
  • 99.15 (n)
  • 100 (a)
NUDCD2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NUDCD2 35
  • 94.69 (n)
  • 98.73 (a)
NUDCD2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUDCD2 35
  • 95.12 (n)
  • 99.36 (a)
NUDCD2 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nudcd2 35
  • 90.23 (n)
  • 99.36 (a)
Nudcd2 16
Nudcd2 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NUDCD2 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUDCD2 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nudcd2 35
  • 87.9 (n)
  • 98.73 (a)
chicken
(Gallus gallus)
Aves NUDCD2 35
  • 81.1 (n)
  • 87.9 (a)
NUDCD2 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUDCD2 36
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.33196 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nudcd2 35
  • 70.28 (n)
  • 77.07 (a)
Str.7314 35
zebrafish
(Danio rerio)
Actinopterygii nudcd2 35
  • 69 (n)
  • 70.06 (a)
nudcd2 36
  • 70 (a)
OneToOne
Species with no ortholog for NUDCD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUDCD2 Gene

ENSEMBL:
Gene Tree for NUDCD2 (if available)
TreeFam:
Gene Tree for NUDCD2 (if available)

Paralogs for NUDCD2 Gene

No data available for Paralogs for NUDCD2 Gene

Variants for NUDCD2 Gene

Sequence variations from dbSNP and Humsavar for NUDCD2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs299301 -- 163,454,502(+) atgcc(C/T)ggcta intron-variant
rs411112 -- 163,457,127(-) ATGAA(A/G)AACTC intron-variant
rs1053108 -- 163,453,618(+) CAAAA(A/G)AAAAA utr-variant-3-prime
rs1345742 -- 163,457,239(+) tgatt(C/T)tcctg intron-variant
rs2431752 -- 163,455,696(+) GAGGC(A/G)GAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUDCD2 Gene

Variant ID Type Subtype PubMed ID
nsv830538 CNV Gain+Loss 17160897

Relevant External Links for NUDCD2 Gene

HapMap Linkage Disequilibrium report
NUDCD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDCD2 Gene

Disorders for NUDCD2 Gene

(1) University of Copenhagen DISEASES for NUDCD2 Gene

genes like me logo Genes that share disorders with NUDCD2: view

No data available for UniProtKB/Swiss-Prot for NUDCD2 Gene

Publications for NUDCD2 Gene

  1. NudC-like protein 2 regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90. (PMID: 20133715) Yang Y. … Zhou T. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3
  4. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3
  5. DNA cloning using in vitro site-specific recombination. (PMID: 11076863) Hartley J.L. … Brasch M.A. (Genome Res. 2000) 3

Products for NUDCD2 Gene

Sources for NUDCD2 Gene

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