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NUDCD2 Gene

protein-coding   GIFtS: 48
GCID: GC05M162880

NudC Domain Containing 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NudC Domain Containing 21 2
NudC Domain-Containing Protein 22
NudC-Like Protein 22

External Ids:    HGNC: 305351   Entrez Gene: 1344922   Ensembl: ENSG000001705847   UniProtKB: Q8WVJ23   

Export aliases for NUDCD2 gene to outside databases

Previous GC identifers: GC05M162800 GC05M157980


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NUDCD2 Gene:
NUDCD2 (NudC domain containing 2) is a protein-coding gene. Diseases associated with NUDCD2 include endometritis, and lissencephaly.

UniProtKB/Swiss-Prot: NUDC2_HUMAN, Q8WVJ2
Function: May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone

Gene Wiki entry for NUDCD2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_023133.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the NUDCD2 gene promoter:
         GR   ATF-2   CBF-C   CREB   CBF-A   CBF-B   deltaCREB   CP1A   GR-alpha   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNUDCD2 promoter sequence
   Search Chromatin IP Primers for NUDCD2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NUDCD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q34   Ensembl cytogenetic band:  5q34   HGNC cytogenetic band: 5q34

NUDCD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUDCD2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M162880:  view genomic region     (about GC identifiers)

Start:
162,873,532 bp from pter      End:
162,887,146 bp from pter
Size:
13,615 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NUDC2_HUMAN, Q8WVJ2 (See protein sequence)
Recommended Name: NudC domain-containing protein 2  
Size: 157 amino acids; 17676 Da
Subunit: Interacts with LIS1
Secondary accessions: B2R4V0

Explore the universe of human proteins at neXtProt for NUDCD2: NX_Q8WVJ2

Explore proteomics data for NUDCD2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys65, Lys129, Lys147
  • Modification sites at PhosphoSitePlus

  • See NUDCD2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_660309.1  
    ENSEMBL proteins: 
     ENSP00000304854   ENSP00000430347  

    NUDCD2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR008978 HSP20-like_chaperone
     IPR027763 NUDCD2
     IPR007052 CS_dom

    Graphical View of Domain Structure for InterPro Entry Q8WVJ2

    ProtoNet protein and cluster: Q8WVJ2

    UniProtKB/Swiss-Prot: NUDC2_HUMAN, Q8WVJ2
    Similarity: Contains 1 CS domain


    NUDCD2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NUDC2_HUMAN, Q8WVJ2
    Function: May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    NUDCD2 for ontologies           About GeneDecksing


    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target NUDCD2:
    hsa-mir-100-5p (MIRT048536)

    Block miRNA regulation of human, mouse, rat NUDCD2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate NUDCD2:
    hsa-miR-124 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidNUDCD2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NUDCD2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NUDC2_HUMAN, Q8WVJ2: Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center,
    centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Associates with centrosomes in interphase and to spindle
    poles and kinetochores during mitosis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol2
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0000922spindle pole IEA--
    GO:0005622intracellular IDA--
    GO:0005737cytoplasm IDA--
    GO:0005815microtubule organizing center IEA--

    NUDCD2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NUDCD2
    Interactions:

        Search GeneGlobe Interaction Network for NUDCD2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for NUDCD2 (Q8WVJ21, 3 ENSP000003048544) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF1BO607393, ENSP000002329054I2D: score=1 STRING: ENSP00000232905
    PRMT5O147441EBI-1052153,EBI-351098
    HSP90AA1ENSP000003351534STRING: ENSP00000335153
    PAFAH1B1ENSP000003803784STRING: ENSP00000380378
    ACDENSP000003774964STRING: ENSP00000377496
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NUDCD2 (NUDC2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NUDCD2 gene: 
    NM_145266.4  

    Unigene Cluster for NUDCD2:

    NudC domain containing 2
    Hs.140443  [show with all ESTs]
    Unigene Representative Sequence: AK094647
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000302764(uc003lze.3) ENST00000517501 ENST00000519395 ENST00000521797

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate NUDCD2:
    hsa-miR-124 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidNUDCD2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NUDCD2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUDCD2
    Primer
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    OriGene qPCR primer pairs and template standards for NUDCD2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NUDCD2
      QuantiTect SYBR Green Assays in human, mouse, rat NUDCD2
      QuantiFast Probe-based Assays in human, mouse, rat NUDCD2

    Additional mRNA sequence: 

    AK094647.1 AK311957.1 BC017934.1 FJ215684.1 

    8 DOTS entries:

    DT.99969051  DT.114959  DT.92429085  DT.75178725  DT.40303497  DT.120888678  DT.92429086  DT.95240085 

    Selected AceView cDNA sequences (see all 137):

    CA308189 AI570407 BF057130 AI340931 AI458151 AI301560 AA442178 NM_145266 
    BF434910 AA854471 AW471230 AI291200 CB116388 BE467221 BE466719 CB217724 
    BF062961 AI263083 AI216845 BU687138 CA419133 BX538290 AI057281 F11371 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NUDCD2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5
    SP1:              -     -                     
    SP2:                    -                     
    SP3:                                          


    ECgene alternative splicing isoforms for NUDCD2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NUDCD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAAATGAAG
    NUDCD2 Expression
    About this image

    NUDCD2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NUDCD2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.140443
        Custom PCR Arrays for NUDCD2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDCD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NUDCD2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nudcd21 , 5 NudC domain containing 21, 5 90.23(n)1
    99.36(a)1
      11 (24.41 cM)5
    526531  NM_026023.41  NP_080299.41 
     407336675 
    chicken
    (Gallus gallus)
    Aves NUDCD21 NudC domain containing 2 81.1(n)
    87.9(a)
      416162  XM_414494.4  XP_414494.3 
    lizard
    (Anolis carolinensis)
    Reptilia NUDCD26
    NudC domain containing 2
    80(a)
    1 ↔ 1
    1(108068997-108074793)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.331962 Xenopus laevis transcribed sequence with weak similarity more 74.36(n)    CB593321.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AL927218.12   -- 75.15(n)    AL927218.1 


    ENSEMBL Gene Tree for NUDCD2 (if available)
    TreeFam Gene Tree for NUDCD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NUDCD2 (see all 125)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs798867501,2
    C,F--162880086(+) TAGTAA/GTCAGT 1 -- int13Minor allele frequency- G:0.11WA CSA 122
    rs1830900771,2
    C--162880229(+) GGATAC/TTGAAT 1 -- int10--------
    rs1388680691,2
    --162880366(+) ACACTG/TCTCTT 1 -- int10--------
    rs733260351,2
    C,F--162880382(+) TTAATC/TCACTT 1 -- int11Minor allele frequency- T:0.50WA 2
    rs1117442181,2
    F--162880418(+) TAAACG/TTCTTG 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1906279991,2
    --162880491(+) ACTTAA/CAATAC 1 -- int10--------
    rs10531081,2
    C,F,H--162880624(+) CAAAAG/AAAAAA 1 -- ut315Minor allele frequency- A:0.01NS 1016
    rs98851351,2
    C,F--162880665(+) CACATG/CATCTA 1 -- ut311Minor allele frequency- C:0.50CSA 2
    rs98850261,2
    C--162880703(+) TATGGA/TTAAAT 1 -- ut310--------
    rs1831575481,2
    --162880888(+) CATCCA/GCATTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NUDCD2 (162873532 - 162887146 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NUDCD2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830538CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NUDCD2
    DNA2.0 Custom Variant and Variant Library Synthesis for NUDCD2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for NUDCD2:    About MalaCards
    endometritis    lissencephaly

    1 disease from the University of Copenhagen DISEASES database for NUDCD2:
    Endometritis

    NUDCD2 for disorders           About GeneDecksing


    Export disorders for NUDCD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NUDCD2 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with NUDCD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NudC-like protein 2 regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90. (PubMed id 20133715)1, 2 Yang Y.... Zhou T. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    4. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 134492 HGNC: 30535 AceView: LOC134492 Ensembl:ENSG00000170584 euGenes: HUgn134492
    ECgene: NUDCD2 H-InvDB: NUDCD2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NUDCD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NUDCD2 gene:
    Search GeneIP for patents involving NUDCD2

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for NUDCD2  
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     Block miRNA regulation of human, mouse, rat NUDCD2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NUDCD2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NUDCD2 Predesigned siRNA for gene silencing in human, mouse, rat NUDCD2
     QuantiFast Probe-based Assays in human, mouse, rat NUDCD2 QuantiTect SYBR Green Assays in human, mouse, rat NUDCD2
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     Search Tocris compounds for NUDCD2 (NUDC2)
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     Novus Tissue Slides
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     Browse ESI BIO Cell Lines and PureStem Progenitors for NUDCD2
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUDCD2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NUDCD2
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