NUDCD2 Gene
protein-coding GIFtS: 46
GCID: GC05M162880
|
|
NudC domain containing 2
| |
Aliases
for NUDCD2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| NudC Domain Containing 21 2 | | DKFZp686E101091 | | NudC Domain-Containing Protein 22 | | NudC-Like Protein 22 |
Export aliases for NUDCD2 gene to outside databasesPrevious GC identifers: GC05M162800 GC05M157980 |
Summaries
for NUDCD2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: NUDC2_HUMAN, Q8WVJ2Function: May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone
Gene Wiki entry for NUDCD2
|
Genomic Views
for NUDCD2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_023133.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NUDCD2 gene promoter:
GR ATF-2 CBF-C CREB CBF-A CBF-B deltaCREB CP1A GR-alpha CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for NUDCD2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUDCD2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q34 Ensembl cytogenetic band: 5q34 HGNC cytogenetic band: 5q34NUDCD2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M162880: view genomic region
(about GC identifiers)
Start:
|
162,880,494 bp from pter |
End:
|
162,887,146 bp from pter |
Size:
|
6,653 bases |
Orientation:
|
minus strand |
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Proteins
for NUDCD2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NUDC2_HUMAN, Q8WVJ2 (See
protein sequence)Recommended Name: NudC domain-containing protein 2 Size: 157 amino acids; 17676 Da
Subunit: Interacts with LIS1
Subcellular location: Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, centrosome. Cytoplasm,cytoskeleton, spindle pole. Note=Associates with centrosomes in interphase and to spindle poles and kinetochoresduring mitosis
Secondary accessions: B2R4V0Explore the universe of human proteins at neXtProt for NUDCD2: NX_Q8WVJ2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WVJ2
NUDCD2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_660309.1
ENSEMBL proteins: ENSP00000304854 ENSP00000430347
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
NUDCD2 for ontologies About GeneDecksing
NUDCD2 Antibody Products:
Assay Products for NUDCD2: |
Protein
Domains /
Families
for NUDCD2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NUDCD2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WVJ2ProtoNet protein and cluster: Q8WVJ2 UniProtKB/Swiss-Prot: NUDC2_HUMAN, Q8WVJ2Similarity: Contains 1 CS domain |
Function
for NUDCD2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NUDC2_HUMAN, Q8WVJ2Function: May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUDCD2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUDCD2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDCD2 |
|
Pathways & Interactions
for NUDCD2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NUDCD2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/8 Interacting proteins for NUDCD2 (Q8WVJ23 ENSP000003048544) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
|
Drugs & Compounds
for NUDCD2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NUDCD2
Search CenterWatch for drugs/clinical trials and news about NUDCD2 / NUDC2
|
Transcripts
for NUDCD2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NUDCD2 gene: NM_145266.4 Unigene Cluster for NUDCD2: NudC domain containing 2 Hs.140443 [show with all ESTs]Unigene Representative Sequence: AK0946474 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000302764(uc003lze.3) ENST00000517501 ENST00000519395 ENST00000521797
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUDCD2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUDCD2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NUDCD2 (NM_145266) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NUDCD2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUDCD2 |
Additional cDNA sequence: AK094647.1 AK311957.1 BC017934.1 FJ215684.1 8 DOTS entries: DT.99969051 DT.114959 DT.92429085 DT.75178725 DT.40303497 DT.120888678 DT.92429086 DT.95240085 24/137 AceView cDNA sequences (see all 137): AI216845 AI948774 CB217724 AA442178 BE466719 AI298938 AA411536 BF115990 AI992355 BF434910 AA702786 AA854471 AI263083 F11371 BF591981 AI300345 AI340931 BF057130 AI348059 AW083096 AA442075 AW471230 AI301560 CA419133
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for NUDCD2 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 |
|---|
|
| SP1: | | | | | - | | - | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NUDCD2
|
Expression
for NUDCD2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NUDCD2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAAATGAAG
About this image
See NUDCD2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NUDCD2
SOURCE GeneReport for Unigene cluster: Hs.140443
SABiosciences Custom PCR Arrays for NUDCD2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUDCD2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NUDCD2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUDCD2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUDCD2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDCD2 |
Orthologs
for NUDCD2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for NUDCD2 gene from 6/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Nudcd21 , 5 |
NudC domain containing 21, 5 |
90.23(n)1
99.36(a)1 |
|
11 (24.41 cM)5
526531 NM_026023.41 NP_080299.41
407336675 |
chicken
(Gallus gallus) |
Aves |
NUDCD21 |
NudC domain containing 2 |
81.1(n)
87.9(a) |
|
416162 XM_414494.3 XP_414494.2 |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.331962 |
Xenopus laevis transcribed sequence with weak similarity more |
74.36(n) |
|
CB593321.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
AL927218.12 |
-- |
75.15(n) |
|
AL927218.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT5G587406 |
nudC domain-containing protein |
34(a) |
1 ↔ 1 |
5(23725774-23727614) |
rice
(Oryza sativa) |
Liliopsida |
-- |
CS domain containing protein, putative, expressed |
33(a) |
1 ↔ 1 |
1(27335216-27338319) |
ENSEMBL Gene Tree for NUDCD2 (if available)
TreeFam Gene Tree for NUDCD2 (if available) |
Paralogs
for NUDCD2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for NUDCD2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NUDCD2 (162880494 - 162887146 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for NUDCD2
1 CNV: 93332 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NUDCD2 |
|
Disorders
/ Diseases
for NUDCD2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NUDCD2 for disorders About GeneDecksing
3  diseases for NUDCD2: About MalaCardsendometritis lissencephaly malaria
1 disease from the University of Copenhagen DISEASES database for NUDCD2:Endometritis Export disorders for NUDCD2 gene to outside databases
|
Publications
for NUDCD2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NUDCD2 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with NUDCD2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- NudC-like protein 2 regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90. (PubMed id 20133715)1, 2 Yang Y....Zhou T. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
|
External Searches for NUDCD2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NUDCD2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NUDCD2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NUDCD2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NUDCD2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NUDCD2 gene:
Search GeneIP for patents involving NUDCD2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NUDCD2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NUDCD2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NUDCD2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUDCD2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUDCD2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUDCD2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUDCD2 |
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| |  |  |  |  | | | | |
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 | | | NUDCD2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDCD2 |
|  |  |  | | | | ThermoFisher Antibodies for NUDCD2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUDCD2 |
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