Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NUDCD1 Gene

Aliases for NUDCD1 Gene

  • NudC Domain Containing 1 2 3
  • CML66 3 4 6
  • Chronic Myelogenous Leukemia Tumor Antigen 66 3 4
  • Tumor Antigen CML66 3 4
  • NudC Domain-Containing Protein 1 3
  • OVA66 3

External Ids for NUDCD1 Gene

Previous GeneCards Identifiers for NUDCD1 Gene

  • GC08M110323
  • GC08M105575

Summaries for NUDCD1 Gene

GeneCards Summary for NUDCD1 Gene

NUDCD1 (NudC Domain Containing 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDCD1 Gene

Genomics for NUDCD1 Gene

Regulatory Elements for NUDCD1 Gene

Genomic Location for NUDCD1 Gene

Start:
109,240,919 bp from pter
End:
109,334,385 bp from pter
Size:
93,467 bases
Orientation:
Minus strand

Genomic View for NUDCD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUDCD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDCD1 Gene

Proteins for NUDCD1 Gene

  • Protein details for NUDCD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RS6-NUDC1_HUMAN
    Recommended name:
    NudC domain-containing protein 1
    Protein Accession:
    Q96RS6
    Secondary Accessions:
    • B4DVX6
    • Q4G130
    • Q8NDQ5
    • Q8NG18
    • Q96SI4
    • Q9BVR5

    Protein attributes for NUDCD1 Gene

    Size:
    583 amino acids
    Molecular mass:
    66756 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Isoform 1 is the dominant immunogenic isoform and is capable of eliciting a humoral response in individuals with a variety of solid tumors. Expression of isoform 1 in a wide variety of malignancies as well as the presence of an immunogenic epitope suggest that it may be a suitable target for antigen-specific immunotherapy.

    Alternative splice isoforms for NUDCD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUDCD1 Gene

Proteomics data for NUDCD1 Gene at MOPED

Post-translational modifications for NUDCD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUDCD1 Gene

No data available for DME Specific Peptides for NUDCD1 Gene

Domains for NUDCD1 Gene

Protein Domains for NUDCD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NUDCD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96RS6

UniProtKB/Swiss-Prot:

NUDC1_HUMAN :
  • Q96RS6
Domain:
  • Contains 1 CS domain.
genes like me logo Genes that share domains with NUDCD1: view

No data available for Gene Families for NUDCD1 Gene

Function for NUDCD1 Gene

Gene Ontology (GO) - Molecular Function for NUDCD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25036637
genes like me logo Genes that share ontologies with NUDCD1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NUDCD1 Gene

Localization for NUDCD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDCD1 Gene

Isoform 1: Cytoplasm. Nucleus.
Isoform 2: Cytoplasm.
Isoform 3: Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUDCD1 Gene COMPARTMENTS Subcellular localization image for NUDCD1 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for NUDCD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with NUDCD1: view

Pathways for NUDCD1 Gene

SuperPathways for NUDCD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NUDCD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
genes like me logo Genes that share ontologies with NUDCD1: view

No data available for Pathways by source for NUDCD1 Gene

Transcripts for NUDCD1 Gene

Unigene Clusters for NUDCD1 Gene

NudC domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUDCD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2: - -
SP3: -

Relevant External Links for NUDCD1 Gene

GeneLoc Exon Structure for
NUDCD1
ECgene alternative splicing isoforms for
NUDCD1

Expression for NUDCD1 Gene

mRNA expression in normal human tissues for NUDCD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUDCD1 Gene

SOURCE GeneReport for Unigene cluster for NUDCD1 Gene Hs.380291

mRNA Expression by UniProt/SwissProt for NUDCD1 Gene

Q96RS6-NUDC1_HUMAN
Tissue specificity: Isoform 1 is specifically expressed in leukemias and a variety of solid tumor cell lines and is also detected in testis and heart. Isoform 2 is predominantly expressed in testis and weakly expressed in tumor cells.
genes like me logo Genes that share expressions with NUDCD1: view

No data available for mRNA differential expression in normal tissues for NUDCD1 Gene

Orthologs for NUDCD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUDCD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUDCD1 35
  • 99.71 (n)
  • 99.66 (a)
NUDCD1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NUDCD1 35
  • 92.11 (n)
  • 91.94 (a)
NUDCD1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUDCD1 35
  • 92.91 (n)
  • 93.83 (a)
NUDCD1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nudcd1 35
  • 89.18 (n)
  • 90.33 (a)
Nudcd1 16
Nudcd1 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NUDCD1 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUDCD1 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nudcd1 35
  • 89.02 (n)
  • 90.29 (a)
chicken
(Gallus gallus)
Aves NUDCD1 35
  • 75.19 (n)
  • 75.64 (a)
NUDCD1 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUDCD1 36
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia cml66-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nudcd1 35
  • 68.92 (n)
  • 68.11 (a)
Str.15325 35
zebrafish
(Danio rerio)
Actinopterygii nudcd1 35
  • 61.27 (n)
  • 58.71 (a)
nudcd1 36
  • 58 (a)
OneToOne
wufc11c02 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000648 35
  • 42.62 (n)
  • 32.02 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10347 35
  • 40.66 (n)
  • 27.84 (a)
CG10347 36
  • 24 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C44E4.5 35
  • 42.34 (n)
  • 27.41 (a)
C44E4.5 36
  • 27 (a)
OneToOne
Species with no ortholog for NUDCD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUDCD1 Gene

ENSEMBL:
Gene Tree for NUDCD1 (if available)
TreeFam:
Gene Tree for NUDCD1 (if available)

Paralogs for NUDCD1 Gene

No data available for Paralogs for NUDCD1 Gene

Variants for NUDCD1 Gene

Sequence variations from dbSNP and Humsavar for NUDCD1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs720574 -- 109,314,259(-) ATGTT(A/G)CCTTA intron-variant, upstream-variant-2KB
rs1026482 -- 109,245,077(-) TAACC(A/G)CTTGA intron-variant
rs1047345 -- 109,246,707(-) GTTTC(A/G/T)TATTT intron-variant
rs1138633 -- 109,302,714(+) gatag(C/T)gttta intron-variant
rs1138634 -- 109,302,715(+) ttagc(A/G)tttag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUDCD1 Gene

Variant ID Type Subtype PubMed ID
nsv891272 CNV Loss 21882294
dgv7843n71 CNV Loss 21882294
dgv7844n71 CNV Loss 21882294
dgv7845n71 CNV Loss 21882294
nsv515589 CNV Loss 19592680
nsv6346 CNV Insertion 18451855

Relevant External Links for NUDCD1 Gene

HapMap Linkage Disequilibrium report
NUDCD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDCD1 Gene

Disorders for NUDCD1 Gene

Relevant External Links for NUDCD1

Genetic Association Database (GAD)
NUDCD1
genes like me logo Genes that share disorders with NUDCD1: view

No data available for UniProtKB/Swiss-Prot for NUDCD1 Gene

Publications for NUDCD1 Gene

  1. CML66, a broadly immunogenic tumor antigen, elicits a humoral immune response associated with remission of chronic myelogenous leukemia. (PMID: 11416219) Yang X.-F. … Ritz J. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3 4
  2. A novel mechanism of alternative promoter and splicing regulates the epitope generation of tumor antigen CML66-L. (PMID: 14688378) Yan Y. … Yang X.-F. (J. Immunol. 2004) 3 4
  3. RNA interference targeting CML66, a novel tumor antigen, inhibits proliferation, invasion and metastasis of HeLa cells. (PMID: 18534745) Wang Q. … Ge H. (Cancer Lett. 2008) 3
  4. Humoral immune responses against tumor-associated antigen OVA66 originally defined by serological analysis of recombinant cDNA expression libraries and its potentiality in cellular immunity. (PMID: 18754882) Jin S. … Ge H.L. (Cancer Sci. 2008) 3
  5. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3

Products for NUDCD1 Gene

Sources for NUDCD1 Gene

Back to Top

Content