Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NUDCD1 Gene

Aliases for NUDCD1 Gene

  • NudC Domain Containing 1 2 3 5
  • Chronic Myelogenous Leukemia Tumor Antigen 66 3 4
  • Tumor Antigen CML66 3 4
  • CML66 3 4
  • NudC Domain-Containing Protein 1 3
  • OVA66 3

External Ids for NUDCD1 Gene

Previous GeneCards Identifiers for NUDCD1 Gene

  • GC08M110323
  • GC08M105575

Summaries for NUDCD1 Gene

GeneCards Summary for NUDCD1 Gene

NUDCD1 (NudC Domain Containing 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDCD1 Gene

Genomics for NUDCD1 Gene

Regulatory Elements for NUDCD1 Gene

Enhancers for NUDCD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F109331 1.1 ENCODE 14.7 +0.8 752 4.2 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 YY1 PKHD1L1 NUDCD1 EIF3E ENY2 ENSG00000250267
GH08F109576 1.2 FANTOM5 Ensembl ENCODE 9.9 -242.8 -242781 0.5 PKNOX1 MAX REST FEZF1 GATA3 GATA2 IKZF1 PRDM10 NFE2 LOC100132813 SYBU ENY2 NUDCD1 GC08P109564
GH08F109575 0.8 Ensembl ENCODE 9.9 -241.4 -241410 0.9 ZNF263 SCRT1 ZNF362 GATA3 NFIA CEBPG LOC100132813 SYBU ENY2 NUDCD1 EBAG9 GC08P109564
GH08F109538 1.2 ENCODE 6.4 -206.2 -206241 3.8 HDGF PKNOX1 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 PKHD1L1 NUDCD1 MAPK6PS5 EBAG9 GC08P109564
GH08F109450 0.7 ENCODE 10.2 -116.7 -116692 0.2 SOX5 CTCF ATF1 ZNF654 PKNOX1 TRIM22 REST RAD21 CBX1 GATA2 ENY2 NUDCD1 MAPK6PS5 LOC100420748
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NUDCD1 on UCSC Golden Path with GeneCards custom track

Promoters for NUDCD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001399008 85 3401 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 YY1

Genomic Location for NUDCD1 Gene

Chromosome:
8
Start:
109,240,919 bp from pter
End:
109,334,385 bp from pter
Size:
93,467 bases
Orientation:
Minus strand

Genomic View for NUDCD1 Gene

Genes around NUDCD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDCD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDCD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDCD1 Gene

Proteins for NUDCD1 Gene

  • Protein details for NUDCD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RS6-NUDC1_HUMAN
    Recommended name:
    NudC domain-containing protein 1
    Protein Accession:
    Q96RS6
    Secondary Accessions:
    • B4DVX6
    • Q4G130
    • Q8NDQ5
    • Q8NG18
    • Q96SI4
    • Q9BVR5

    Protein attributes for NUDCD1 Gene

    Size:
    583 amino acids
    Molecular mass:
    66756 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Isoform 1 is the dominant immunogenic isoform and is capable of eliciting a humoral response in individuals with a variety of solid tumors. Expression of isoform 1 in a wide variety of malignancies as well as the presence of an immunogenic epitope suggest that it may be a suitable target for antigen-specific immunotherapy.

    Alternative splice isoforms for NUDCD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUDCD1 Gene

Post-translational modifications for NUDCD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUDCD1 Gene

No data available for DME Specific Peptides for NUDCD1 Gene

Domains & Families for NUDCD1 Gene

Gene Families for NUDCD1 Gene

Protein Domains for NUDCD1 Gene

Suggested Antigen Peptide Sequences for NUDCD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96RS6

UniProtKB/Swiss-Prot:

NUDC1_HUMAN :
  • Contains 1 CS domain.
Domain:
  • Contains 1 CS domain.
genes like me logo Genes that share domains with NUDCD1: view

Function for NUDCD1 Gene

Gene Ontology (GO) - Molecular Function for NUDCD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25036637
genes like me logo Genes that share ontologies with NUDCD1: view
genes like me logo Genes that share phenotypes with NUDCD1: view

Animal Model Products

miRNA for NUDCD1 Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUDCD1 Gene

Localization for NUDCD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDCD1 Gene

Isoform 1: Cytoplasm. Nucleus.
Isoform 2: Cytoplasm.
Isoform 3: Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUDCD1 gene
Compartment Confidence
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for NUDCD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with NUDCD1: view

Pathways & Interactions for NUDCD1 Gene

SuperPathways for NUDCD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NUDCD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
genes like me logo Genes that share ontologies with NUDCD1: view

No data available for Pathways by source and SIGNOR curated interactions for NUDCD1 Gene

Transcripts for NUDCD1 Gene

Unigene Clusters for NUDCD1 Gene

NudC domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUDCD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2: - -
SP3: -

Relevant External Links for NUDCD1 Gene

GeneLoc Exon Structure for
NUDCD1
ECgene alternative splicing isoforms for
NUDCD1

Expression for NUDCD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NUDCD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NUDCD1 Gene

This gene is overexpressed in Breast (30.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NUDCD1 Gene



Protein tissue co-expression partners for NUDCD1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NUDCD1 Gene:

NUDCD1

SOURCE GeneReport for Unigene cluster for NUDCD1 Gene:

Hs.380291

mRNA Expression by UniProt/SwissProt for NUDCD1 Gene:

Q96RS6-NUDC1_HUMAN
Tissue specificity: Isoform 1 is specifically expressed in leukemias and a variety of solid tumor cell lines and is also detected in testis and heart. Isoform 2 is predominantly expressed in testis and weakly expressed in tumor cells.
genes like me logo Genes that share expression patterns with NUDCD1: view

No data available for mRNA differential expression in normal tissues for NUDCD1 Gene

Orthologs for NUDCD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUDCD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUDCD1 34 35
  • 99.71 (n)
dog
(Canis familiaris)
Mammalia NUDCD1 34 35
  • 92.91 (n)
cow
(Bos Taurus)
Mammalia NUDCD1 34 35
  • 92.11 (n)
mouse
(Mus musculus)
Mammalia Nudcd1 34 16 35
  • 89.18 (n)
rat
(Rattus norvegicus)
Mammalia Nudcd1 34
  • 89.02 (n)
oppossum
(Monodelphis domestica)
Mammalia NUDCD1 35
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUDCD1 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUDCD1 34 35
  • 75.19 (n)
lizard
(Anolis carolinensis)
Reptilia NUDCD1 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nudcd1 34
  • 68.92 (n)
Str.15325 34
African clawed frog
(Xenopus laevis)
Amphibia cml66-prov 34
zebrafish
(Danio rerio)
Actinopterygii nudcd1 34 35
  • 61.27 (n)
wufc11c02 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000648 34
  • 42.62 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10347 34 35
  • 40.66 (n)
worm
(Caenorhabditis elegans)
Secernentea C44E4.5 34 35
  • 42.34 (n)
Species where no ortholog for NUDCD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUDCD1 Gene

ENSEMBL:
Gene Tree for NUDCD1 (if available)
TreeFam:
Gene Tree for NUDCD1 (if available)

Paralogs for NUDCD1 Gene

No data available for Paralogs for NUDCD1 Gene

Variants for NUDCD1 Gene

Sequence variations from dbSNP and Humsavar for NUDCD1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10094863 -- 109,326,966(+) CAATA(C/T)TTAAC intron-variant
rs10103565 -- 109,331,389(+) cgggc(A/G)cctgt intron-variant, upstream-variant-2KB
rs10105653 -- 109,284,003(+) aaaaa(A/C)aaaac intron-variant
rs10108349 -- 109,310,849(+) tcttg(C/T)tctgc intron-variant
rs10112658 -- 109,291,113(+) ATTCC(A/G)TGGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUDCD1 Gene

Variant ID Type Subtype PubMed ID
nsv6346 CNV insertion 18451855
nsv515589 CNV loss 19592680
esv3618372 CNV loss 21293372
esv3618371 CNV loss 21293372
dgv7281n100 CNV loss 25217958

Variation tolerance for NUDCD1 Gene

Residual Variation Intolerance Score: 61.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.85; 91.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUDCD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUDCD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDCD1 Gene

Disorders for NUDCD1 Gene

Relevant External Links for NUDCD1

Genetic Association Database (GAD)
NUDCD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUDCD1

No disorders were found for NUDCD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUDCD1 Gene

Publications for NUDCD1 Gene

  1. CML66, a broadly immunogenic tumor antigen, elicits a humoral immune response associated with remission of chronic myelogenous leukemia. (PMID: 11416219) Yang X.-F. … Ritz J. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3 4 64
  2. A novel mechanism of alternative promoter and splicing regulates the epitope generation of tumor antigen CML66-L. (PMID: 14688378) Yan Y. … Yang X.-F. (J. Immunol. 2004) 3 4 64
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M. … Lindquist S. (Cell 2014) 3 64

Products for NUDCD1 Gene

Sources for NUDCD1 Gene

Content
Loading form....