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Aliases for NUDC Gene

Aliases for NUDC Gene

  • NudC Nuclear Distribution Protein 2 3
  • Nuclear Distribution Protein C Homolog 3 4
  • Nuclear Distribution Gene C Homolog (A. Nidulans) 2
  • Nuclear Distribution C Homolog (A. Nidulans) 2
  • Nuclear Distribution Gene C Homolog 3
  • Nuclear Distribution C Homolog 3
  • Nuclear Migration Protein NudC 3
  • NPD011 3
  • HNUDC 3
  • MNUDC 3

External Ids for NUDC Gene

Summaries for NUDC Gene

Entrez Gene Summary for NUDC Gene

  • This gene encodes a nuclear distribution protein that plays an essential role in mitosis and cytokinesis. The encoded protein is involved in spindle formation during mitosis and in microtubule organization during cytokinesis. Pseudogenes of this gene are found on chromosome 2. [provided by RefSeq, Feb 2012]

GeneCards Summary for NUDC Gene

NUDC (NudC Nuclear Distribution Protein) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. An important paralog of this gene is NUDCD3.

UniProtKB/Swiss-Prot for NUDC Gene

  • Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.

Gene Wiki entry for NUDC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDC Gene

Genomics for NUDC Gene

Genomic Location for NUDC Gene

Start:
26,900,238 bp from pter
End:
26,946,871 bp from pter
Size:
46,634 bases
Orientation:
Plus strand

Genomic View for NUDC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUDC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDC Gene

Regulatory Elements for NUDC Gene

Proteins for NUDC Gene

  • Protein details for NUDC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y266-NUDC_HUMAN
    Recommended name:
    Nuclear migration protein nudC
    Protein Accession:
    Q9Y266
    Secondary Accessions:
    • Q5QP31
    • Q5QP35
    • Q9H0N2
    • Q9Y2B6

    Protein attributes for NUDC Gene

    Size:
    331 amino acids
    Molecular mass:
    38243 Da
    Quaternary structure:
    • Binds PLK1. Binds PAFAH1B1 (By similarity). Part of a complex containing PLK1, NUDC, dynein and dynactin.
    SequenceCaution:
    • Sequence=BAA76628.1; Type=Frameshift; Positions=140, 231, 273; Evidence={ECO:0000305}; Sequence=CAI13560.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13563.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NUDC Gene

neXtProt entry for NUDC Gene

Proteomics data for NUDC Gene at MOPED

Post-translational modifications for NUDC Gene

  • Reversibly phosphorylated on serine residues during the M phase of the cell cycle. Phosphorylation on Ser-274 and Ser-326 is necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Phosphorylated by PLK and other kinases.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys68, Lys196, Lys250, Lys275, and Lys315

Other Protein References for NUDC Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NUDC Gene

Domains for NUDC Gene

Protein Domains for NUDC Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NUDC Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y266

UniProtKB/Swiss-Prot:

NUDC_HUMAN
Domain:
  • Contains 1 CS domain.:
    • Q9Y266
Family:
  • Belongs to the nudC family.:
    • Q9Y266
genes like me logo Genes that share domains with NUDC: view

No data available for Gene Families for NUDC Gene

Function for NUDC Gene

Molecular function for NUDC Gene

GENATLAS Biochemistry: nuclear distribution gene C,Aspergillus nidulans and mouse ortholog,widely expressed in fetal and adult tissues,coexpressed with LIS1 (PAFAH1B1) in the ventricular zone of developping brain,putatively involved in neuronal migration
UniProtKB/Swiss-Prot Function: Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.
UniProtKB/Swiss-Prot Induction: Up-regulated in actively dividing hematopoietic precursor cells. Up-regulated in cultured erythroleukemia TF-1 cells by granulocyte-macrophage colony-stimulating factor. Strongly down-regulated during maturation of erythroid precursor cells.

Gene Ontology (GO) - Molecular Function for NUDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25036637
genes like me logo Genes that share ontologies with NUDC: view

miRNA for NUDC Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NUDC Gene

Localization for NUDC Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDC Gene

Cytoplasm, cytoskeleton. Nucleus. Note=In a filamentous pattern adjacent to the nucleus of migrating cerebellar granule cells. Colocalizes with tubulin and dynein and with the microtubule organizing center. Distributed throughout the cytoplasm of non-migrating cells. A small proportion is nuclear, in a punctate pattern.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUDC Gene COMPARTMENTS Subcellular localization image for NUDC gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for NUDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with NUDC: view

Pathways for NUDC Gene

genes like me logo Genes that share pathways with NUDC: view

Gene Ontology (GO) - Biological Process for NUDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0007067 mitotic nuclear division IEA --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007275 multicellular organismal development TAS 10210332
GO:0008283 cell proliferation TAS 10210332
genes like me logo Genes that share ontologies with NUDC: view

Transcripts for NUDC Gene

Unigene Clusters for NUDC Gene

Nuclear distribution C homolog (A. nidulans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUDC Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
SP1: - - - - -
SP2: - - -
SP3: - -
SP4: - - - -
SP5:
SP6: -
SP7: - -

Relevant External Links for NUDC Gene

GeneLoc Exon Structure for
NUDC
ECgene alternative splicing isoforms for
NUDC

Expression for NUDC Gene

mRNA expression in normal human tissues for NUDC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUDC Gene

SOURCE GeneReport for Unigene cluster for NUDC Gene Hs.263812

mRNA Expression by UniProt/SwissProt for NUDC Gene

Q9Y266-NUDC_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in fetal liver, kidney, lung and brain. Highly expressed in adult pancreas, kidney, skeletal muscle, liver, lung, placenta, prostate, brain and heart.
genes like me logo Genes that share expressions with NUDC: view

No data available for mRNA differential expression in normal tissues for NUDC Gene

Orthologs for NUDC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUDC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUDC 35
  • 98.49 (n)
  • 97.58 (a)
NUDC 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NUDC 35
  • 90.74 (n)
  • 94.56 (a)
NUDC 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUDC 35
  • 91.44 (n)
  • 94.56 (a)
NUDC 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nudc 35
  • 88.62 (n)
  • 92.15 (a)
Nudc 16
Nudc 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NUDC 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUDC 36
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nudc 35
  • 89.02 (n)
  • 93.05 (a)
chicken
(Gallus gallus)
Aves NUDC 35
  • 75.43 (n)
  • 81.96 (a)
NUDC 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUDC 36
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4183 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nudc 35
  • 68.09 (n)
  • 71.56 (a)
Str.105 35
zebrafish
(Danio rerio)
Actinopterygii nudc 35
  • 78.59 (n)
  • 82.78 (a)
nudc 36
  • 84 (a)
OneToOne
zgc56099 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006117 35
  • 62.33 (n)
  • 59.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta nudC 35
  • 58.74 (n)
  • 54.01 (a)
nudC 36
  • 51 (a)
OneToOne
CG9710 37
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea nud-1 35
  • 55.63 (n)
  • 52.23 (a)
nud-1 36
  • 48 (a)
OneToOne
nud-1 37
  • 49 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.11510 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G27890 35
  • 57.79 (n)
  • 53.25 (a)
rice
(Oryza sativa)
Liliopsida Os.14007 35
Os06g0231300 35
  • 56.79 (n)
  • 50 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.28702 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02588 35
  • 60.93 (n)
  • 58.6 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC19F8.02 35
  • 51.43 (n)
  • 43.05 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4698 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5296 36
  • 54 (a)
OneToOne
Species with no ortholog for NUDC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for NUDC Gene

ENSEMBL:
Gene Tree for NUDC (if available)
TreeFam:
Gene Tree for NUDC (if available)

Paralogs for NUDC Gene

Paralogs for NUDC Gene

Selected SIMAP similar genes for NUDC Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for NUDC Gene

genes like me logo Genes that share paralogs with NUDC: view

Variants for NUDC Gene

Sequence variations from dbSNP and Humsavar for NUDC Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs7866 -- 26,946,353(-) CTGGG(A/G)AGGAC utr-variant-3-prime
rs1048905 -- 26,945,609(+) GAAAA(A/G)ATGAT synonymous-codon, reference
rs1187945 -- 26,934,995(+) ttttt(C/T)ttttg intron-variant
rs1187946 -- 26,942,168(+) gcgcc(C/T)gtaat intron-variant
rs1187947 -- 26,944,481(+) gtagg(A/C)gccac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUDC Gene

Variant ID Type Subtype PubMed ID
nsv834524 CNV Gain+Loss 17160897
nsv508689 CNV Loss 20534489
esv1159948 CNV Insertion 17803354

Relevant External Links for NUDC Gene

HapMap Linkage Disequilibrium report
NUDC
Human Gene Mutation Database (HGMD)
NUDC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDC Gene

Disorders for NUDC Gene

(1) University of Copenhagen DISEASES for NUDC Gene

(1) Novoseek inferred disease relationships for NUDC Gene

Disease -log(P) Hits PubMed IDs
lymphoblastic leukemia acute 29.5 1
genes like me logo Genes that share disorders with NUDC: view

No data available for UniProtKB/Swiss-Prot for NUDC Gene

Publications for NUDC Gene

  1. A homolog of the fungal nuclear migration gene nudC is involved in normal and malignant human hematopoiesis. (PMID: 10210332) Miller B.A. … Osmani S.A. (Exp. Hematol. 1999) 3 4 23
  2. Molecular cloning and characterization of the human NUDC gene. (PMID: 10453739) Matsumoto N. … Ledbetter D.H. (Hum. Genet. 1999) 3 4 23
  3. A role for Plk1 phosphorylation of NudC in cytokinesis. (PMID: 12852857) Zhou T. … Erikson R.L. (Dev. Cell 2003) 3 4 23
  4. A microtubule associated protein (hNUDC) binds to the extracellular domain of thrombopoietin receptor (Mpl). (PMID: 16088917) Pan R.M. … Xu P. (J. Cell. Biochem. 2005) 3 23
  5. Regulation of cell differentiation by hNUDC via a Mpl-dependent mechanism in NIH 3T3 cells. (PMID: 17658515) Zhang Y.P. … Xu P. (Exp. Cell Res. 2007) 3 23

Products for NUDC Gene

Sources for NUDC Gene

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