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Aliases for NUDC Gene

Aliases for NUDC Gene

  • Nuclear Distribution C, Dynein Complex Regulator 2 3 5
  • Nuclear Distribution Protein C Homolog 3 4
  • NudC Nuclear Distribution Protein 2 3
  • Nuclear Distribution Gene C Homolog (A. Nidulans) 2
  • Nuclear Distribution C Homolog (A. Nidulans) 2
  • Nuclear Distribution Gene C Homolog 3
  • Nuclear Distribution C Homolog 3
  • Nuclear Migration Protein NudC 3
  • NPD011 3
  • HNUDC 3
  • MNUDC 3

External Ids for NUDC Gene

Previous GeneCards Identifiers for NUDC Gene

  • GC01M028319
  • GC01P026280
  • GC01P026481
  • GC01P026852
  • GC01P027120
  • GC01P027226
  • GC01P025501

Summaries for NUDC Gene

Entrez Gene Summary for NUDC Gene

  • This gene encodes a nuclear distribution protein that plays an essential role in mitosis and cytokinesis. The encoded protein is involved in spindle formation during mitosis and in microtubule organization during cytokinesis. Pseudogenes of this gene are found on chromosome 2. [provided by RefSeq, Feb 2012]

GeneCards Summary for NUDC Gene

NUDC (Nuclear Distribution C, Dynein Complex Regulator) is a Protein Coding gene. Diseases associated with NUDC include Lissencephaly. Among its related pathways are Mitotic Telophase/Cytokinesis and Lissencephaly gene (LIS1) in neuronal migration and development. An important paralog of this gene is NUDCD3.

UniProtKB/Swiss-Prot for NUDC Gene

  • Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.

Gene Wiki entry for NUDC Gene

Additional gene information for NUDC Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDC Gene

Genomics for NUDC Gene

GeneHancer (GH) Regulatory Elements for NUDC Gene

Promoters and enhancers for NUDC Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I026920 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.3 +22.4 22372 3.6 HDGF PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 NUDC ARID1A ACTG1P20 FAM76A PIGV NPM1P39 MAP3K6 LOC101928728 ENSG00000231344 HMGN2
GH01I026898 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 -0.2 -187 2.4 PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 GPATCH3 NUDC ARID1A HMGN2 ACTG1P20 PIGV ZNF593 FAM76A NPM1P39 MAP3K6
GH01I026856 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.6 -38.5 -38495 9.6 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A ZNF2 YY1 POLR2B ZNF213 SFN ARID1A HMGN2 LOC101928324 GPATCH3 LOC101928728 ACTG1P20 ENSG00000231344 NPM1P39 PIGV
GH01I026691 Promoter/Enhancer 3.3 UCNEbase EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.1 -203.2 -203180 12.9 MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 ARID1A LOC101928728 HMGN2 ACTG1P20 PIGV LOC101928324 GPN2 GPATCH3 TMEM222 RPL17P9
GH01I026990 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.5 +96.6 96555 13.3 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 SLC30A9 ZNF143 FOS TRNP1 PIGV NR0B2 NUDC GPATCH3 KDF1 FAM46B TMEM222
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NUDC on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NUDC gene promoter:

Genomic Locations for NUDC Gene

Genomic Locations for NUDC Gene
chr1:26,900,238-26,946,871
(GRCh38/hg38)
Size:
46,634 bases
Orientation:
Plus strand
chr1:27,226,729-27,273,353
(GRCh37/hg19)

Genomic View for NUDC Gene

Genes around NUDC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDC Gene

Proteins for NUDC Gene

  • Protein details for NUDC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y266-NUDC_HUMAN
    Recommended name:
    Nuclear migration protein nudC
    Protein Accession:
    Q9Y266
    Secondary Accessions:
    • Q5QP31
    • Q5QP35
    • Q9H0N2
    • Q9Y2B6

    Protein attributes for NUDC Gene

    Size:
    331 amino acids
    Molecular mass:
    38243 Da
    Quaternary structure:
    • Binds PLK1. Binds PAFAH1B1 (By similarity). Part of a complex containing PLK1, NUDC, dynein and dynactin.
    SequenceCaution:
    • Sequence=BAA76628.1; Type=Frameshift; Positions=140, 231, 273; Evidence={ECO:0000305}; Sequence=CAI13560.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13563.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NUDC Gene

neXtProt entry for NUDC Gene

Post-translational modifications for NUDC Gene

  • Reversibly phosphorylated on serine residues during the M phase of the cell cycle. Phosphorylation on Ser-274 and Ser-326 is necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Phosphorylated by PLK and other kinases.
  • Ubiquitination at Lys68, isoforms=250, isoforms=275, and isoforms=315

Other Protein References for NUDC Gene

No data available for DME Specific Peptides for NUDC Gene

Domains & Families for NUDC Gene

Gene Families for NUDC Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for NUDC Gene

Suggested Antigen Peptide Sequences for NUDC Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y266

UniProtKB/Swiss-Prot:

NUDC_HUMAN :
  • Belongs to the nudC family.
Family:
  • Belongs to the nudC family.
genes like me logo Genes that share domains with NUDC: view

Function for NUDC Gene

Molecular function for NUDC Gene

GENATLAS Biochemistry:
nuclear distribution gene C,Aspergillus nidulans and mouse ortholog,widely expressed in fetal and adult tissues,coexpressed with LIS1 (PAFAH1B1) in the ventricular zone of developping brain,putatively involved in neuronal migration
UniProtKB/Swiss-Prot Function:
Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.
UniProtKB/Swiss-Prot Induction:
Up-regulated in actively dividing hematopoietic precursor cells. Up-regulated in cultured erythroleukemia TF-1 cells by granulocyte-macrophage colony-stimulating factor. Strongly down-regulated during maturation of erythroid precursor cells.

Phenotypes From GWAS Catalog for NUDC Gene

Gene Ontology (GO) - Molecular Function for NUDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25036637
GO:0045296 cadherin binding IDA 25468996
GO:0051082 unfolded protein binding IBA --
genes like me logo Genes that share ontologies with NUDC: view
genes like me logo Genes that share phenotypes with NUDC: view

miRNA for NUDC Gene

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUDC Gene

Localization for NUDC Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDC Gene

Cytoplasm, cytoskeleton. Nucleus. Note=In a filamentous pattern adjacent to the nucleus of migrating cerebellar granule cells. Colocalizes with tubulin and dynein and with the microtubule organizing center. Distributed throughout the cytoplasm of non-migrating cells. A small proportion is nuclear, in a punctate pattern.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUDC gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NUDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA,IEA 25468996
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with NUDC: view

Pathways & Interactions for NUDC Gene

genes like me logo Genes that share pathways with NUDC: view

Pathways by source for NUDC Gene

SIGNOR curated interactions for NUDC Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NUDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IBA --
GO:0007049 cell cycle IEA --
GO:0007062 sister chromatid cohesion TAS --
GO:0007275 multicellular organism development TAS 10210332
GO:0008283 cell proliferation TAS 10210332
genes like me logo Genes that share ontologies with NUDC: view

Drugs & Compounds for NUDC Gene

(1) Drugs for NUDC Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phenethyl isothiocyanate Investigational Pharma Target 12
genes like me logo Genes that share compounds with NUDC: view

Transcripts for NUDC Gene

Unigene Clusters for NUDC Gene

Nuclear distribution C homolog (A. nidulans):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUDC Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
SP1: - - - - -
SP2: - - -
SP3: - -
SP4: - - - -
SP5:
SP6: -
SP7: - -

Relevant External Links for NUDC Gene

GeneLoc Exon Structure for
NUDC
ECgene alternative splicing isoforms for
NUDC

Expression for NUDC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUDC Gene

Protein differential expression in normal tissues from HIPED for NUDC Gene

This gene is overexpressed in Nasal epithelium (12.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NUDC Gene



Protein tissue co-expression partners for NUDC Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NUDC Gene:

NUDC

SOURCE GeneReport for Unigene cluster for NUDC Gene:

Hs.263812

mRNA Expression by UniProt/SwissProt for NUDC Gene:

Q9Y266-NUDC_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in fetal liver, kidney, lung and brain. Highly expressed in adult pancreas, kidney, skeletal muscle, liver, lung, placenta, prostate, brain and heart.

Evidence on tissue expression from TISSUES for NUDC Gene

  • Skin(4.8)
  • Nervous system(4.8)
  • Lung(4.7)
  • Liver(4.6)
  • Eye(4.5)
  • Heart(4.4)
  • Kidney(4.4)
  • Pancreas(2.9)
  • Bone marrow(2.4)
  • Intestine(2.3)
  • Muscle(2.1)
  • Adrenal gland(2)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with NUDC: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUDC Gene

Orthologs for NUDC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUDC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUDC 33 34
  • 98.49 (n)
dog
(Canis familiaris)
Mammalia NUDC 33 34
  • 91.44 (n)
cow
(Bos Taurus)
Mammalia NUDC 33 34
  • 90.74 (n)
rat
(Rattus norvegicus)
Mammalia Nudc 33
  • 89.02 (n)
mouse
(Mus musculus)
Mammalia Nudc 33 16 34
  • 88.62 (n)
oppossum
(Monodelphis domestica)
Mammalia NUDC 34
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUDC 34
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUDC 33 34
  • 75.43 (n)
lizard
(Anolis carolinensis)
Reptilia NUDC 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nudc 33
  • 68.09 (n)
Str.105 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.4183 33
zebrafish
(Danio rerio)
Actinopterygii nudc 33 34
  • 78.59 (n)
zgc56099 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006117 33
  • 62.33 (n)
fruit fly
(Drosophila melanogaster)
Insecta nudC 33 34
  • 58.74 (n)
CG9710 35
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea nud-1 35 33 34
  • 55.63 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G27890 33
  • 57.79 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.11510 33
rice
(Oryza sativa)
Liliopsida Os06g0231300 33
  • 56.79 (n)
Os.14007 33
wheat
(Triticum aestivum)
Liliopsida Ta.28702 33
bread mold
(Neurospora crassa)
Ascomycetes NCU02588 33
  • 60.93 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5296 34
  • 54 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC19F8.02 33
  • 51.43 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4698 33
Species where no ortholog for NUDC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for NUDC Gene

ENSEMBL:
Gene Tree for NUDC (if available)
TreeFam:
Gene Tree for NUDC (if available)

Paralogs for NUDC Gene

Paralogs for NUDC Gene

(1) SIMAP similar genes for NUDC Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for NUDC Gene

genes like me logo Genes that share paralogs with NUDC: view

Variants for NUDC Gene

Sequence variations from dbSNP and Humsavar for NUDC Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs74315349 pathogenic, Obesity, mild, early-onset 26,913,841(+) G/A/C genic_upstream_transcript_variant, intron_variant
rs74315350 pathogenic, Obesity, mild, early-onset 26,912,036(+) C/A genic_upstream_transcript_variant, intron_variant
rs201991593 likely-benign, not specified 26,913,409(+) C/G/T genic_upstream_transcript_variant, intron_variant
rs113654931 uncertain-significance, not specified 26,913,781(+) G/A genic_upstream_transcript_variant, intron_variant
rs768288444 uncertain-significance, not specified 26,913,819(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NUDC Gene

Variant ID Type Subtype PubMed ID
esv1159948 CNV insertion 17803354
nsv1000012 CNV gain 25217958
nsv1126984 CNV deletion 24896259
nsv508689 CNV deletion 20534489
nsv834524 CNV gain+loss 17160897

Variation tolerance for NUDC Gene

Residual Variation Intolerance Score: 42.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUDC Gene

Human Gene Mutation Database (HGMD)
NUDC
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUDC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDC Gene

Disorders for NUDC Gene

MalaCards: The human disease database

(1) MalaCards diseases for NUDC Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
lissencephaly
- elite association - COSMIC cancer census association via MalaCards
Search NUDC in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NUDC

genes like me logo Genes that share disorders with NUDC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUDC Gene

Publications for NUDC Gene

  1. A role for Plk1 phosphorylation of NudC in cytokinesis. (PMID: 12852857) Zhou T … Erikson RL (Developmental cell 2003) 3 4 22 58
  2. A homolog of the fungal nuclear migration gene nudC is involved in normal and malignant human hematopoiesis. (PMID: 10210332) Miller BA … Osmani SA (Experimental hematology 1999) 3 4 22 58
  3. Molecular cloning and characterization of the human NUDC gene. (PMID: 10453739) Matsumoto N … Ledbetter DH (Human genetics 1999) 3 4 22 58
  4. Interference RNA (RNAi)-based silencing of endogenous thrombopoietin receptor (Mpl) in Dami cells resulted in decreased hNUDC-mediated megakaryocyte proliferation and differentiation. (PMID: 19560457) Pang SF … Xu P (Experimental cell research 2009) 3 22 58
  5. hNUDC promotes the cell proliferation and differentiation in a leukemic cell line via activation of the thrombopoietin receptor (Mpl). (PMID: 18288130) Tang YS … Xu P (Leukemia 2008) 3 22 58

Products for NUDC Gene

Sources for NUDC Gene

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