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Aliases for NUDC Gene

Aliases for NUDC Gene

  • Nuclear Distribution C, Dynein Complex Regulator 2 3 5
  • Nuclear Distribution Protein C Homolog 3 4
  • NudC Nuclear Distribution Protein 2 3
  • Nuclear Distribution Gene C Homolog (A. Nidulans) 2
  • Nuclear Distribution C Homolog (A. Nidulans) 2
  • Nuclear Distribution Gene C Homolog 3
  • Nuclear Distribution C Homolog 3
  • Nuclear Migration Protein NudC 3
  • NPD011 3
  • HNUDC 3
  • MNUDC 3

External Ids for NUDC Gene

Previous GeneCards Identifiers for NUDC Gene

  • GC01M028319
  • GC01P026280
  • GC01P026481
  • GC01P026852
  • GC01P027120
  • GC01P027226
  • GC01P025501

Summaries for NUDC Gene

Entrez Gene Summary for NUDC Gene

  • This gene encodes a nuclear distribution protein that plays an essential role in mitosis and cytokinesis. The encoded protein is involved in spindle formation during mitosis and in microtubule organization during cytokinesis. Pseudogenes of this gene are found on chromosome 2. [provided by RefSeq, Feb 2012]

GeneCards Summary for NUDC Gene

NUDC (Nuclear Distribution C, Dynein Complex Regulator) is a Protein Coding gene. Diseases associated with NUDC include Lissencephaly. Among its related pathways are PLK1 signaling events and Mitotic Metaphase and Anaphase. An important paralog of this gene is NUDCD3.

UniProtKB/Swiss-Prot for NUDC Gene

  • Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.

Gene Wiki entry for NUDC Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDC Gene

Genomics for NUDC Gene

Regulatory Elements for NUDC Gene

Enhancers for NUDC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G026691 3.2 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -203.2 -203181 12.9 MLX CREB3L1 AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 HMGN2 NPM1P39 PIGV ACTG1P20 GPATCH3 ZNF593 LOC101928728 SFN ENSG00000226698 FAM46B
GH01G026721 3.1 VISTA Ensembl ENCODE dbSUPER 9.7 -176.6 -176584 3.9 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 PIGV ARID1A SFN GPATCH3 NUDC TRNP1 LOC101928728 GC01P026765
GH01G026856 1.8 FANTOM5 ENCODE dbSUPER 13.5 -38.5 -38496 9.6 CREB3L1 MLX AGO1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D ZNF610 HMGN2 NPM1P39 WASF2 PIGV RPS6KA1 NUDC ZDHHC18 ACTG1P20 RPL17P9 GPATCH3
GH01G026990 2 FANTOM5 Ensembl ENCODE dbSUPER 11.5 +96.6 96556 13.3 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 GPATCH3 PIGV ACTG1P20 NR0B2 NUDC LOC101928728 HMGN2 NPM1P39 TRNP1 LOC101928324
GH01G026618 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10 -279.8 -279843 4.0 CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 SP3 HMGN2 ACTG1P20 ZNF593 AHDC1 LOC101928324 WASF2 NPM1P39 RPL17P9 ARID1A PIGV
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NUDC on UCSC Golden Path with GeneCards custom track

Promoters for NUDC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000003626 162 1601 PKNOX1 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143

Genomic Location for NUDC Gene

Chromosome:
1
Start:
26,900,238 bp from pter
End:
26,946,871 bp from pter
Size:
46,634 bases
Orientation:
Plus strand

Genomic View for NUDC Gene

Genes around NUDC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDC Gene

Proteins for NUDC Gene

  • Protein details for NUDC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y266-NUDC_HUMAN
    Recommended name:
    Nuclear migration protein nudC
    Protein Accession:
    Q9Y266
    Secondary Accessions:
    • Q5QP31
    • Q5QP35
    • Q9H0N2
    • Q9Y2B6

    Protein attributes for NUDC Gene

    Size:
    331 amino acids
    Molecular mass:
    38243 Da
    Quaternary structure:
    • Binds PLK1. Binds PAFAH1B1 (By similarity). Part of a complex containing PLK1, NUDC, dynein and dynactin.
    SequenceCaution:
    • Sequence=BAA76628.1; Type=Frameshift; Positions=140, 231, 273; Evidence={ECO:0000305}; Sequence=CAI13560.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13563.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NUDC Gene

neXtProt entry for NUDC Gene

Post-translational modifications for NUDC Gene

  • Reversibly phosphorylated on serine residues during the M phase of the cell cycle. Phosphorylation on Ser-274 and Ser-326 is necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Phosphorylated by PLK and other kinases.
  • Ubiquitination at Lys68, posLast=250250, Lys275, and Lys315
  • Modification sites at PhosphoSitePlus

Other Protein References for NUDC Gene

No data available for DME Specific Peptides for NUDC Gene

Domains & Families for NUDC Gene

Gene Families for NUDC Gene

Protein Domains for NUDC Gene

Suggested Antigen Peptide Sequences for NUDC Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y266

UniProtKB/Swiss-Prot:

NUDC_HUMAN :
  • Belongs to the nudC family.
Family:
  • Belongs to the nudC family.
genes like me logo Genes that share domains with NUDC: view

Function for NUDC Gene

Molecular function for NUDC Gene

GENATLAS Biochemistry:
nuclear distribution gene C,Aspergillus nidulans and mouse ortholog,widely expressed in fetal and adult tissues,coexpressed with LIS1 (PAFAH1B1) in the ventricular zone of developping brain,putatively involved in neuronal migration
UniProtKB/Swiss-Prot Function:
Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.
UniProtKB/Swiss-Prot Induction:
Up-regulated in actively dividing hematopoietic precursor cells. Up-regulated in cultured erythroleukemia TF-1 cells by granulocyte-macrophage colony-stimulating factor. Strongly down-regulated during maturation of erythroid precursor cells.

Gene Ontology (GO) - Molecular Function for NUDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25036637
GO:0045296 cadherin binding IDA 25468996
GO:0051082 unfolded protein binding IBA --
genes like me logo Genes that share ontologies with NUDC: view
genes like me logo Genes that share phenotypes with NUDC: view

Animal Model Products

CRISPR Products

miRNA for NUDC Gene

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NUDC

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUDC Gene

Localization for NUDC Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDC Gene

Cytoplasm, cytoskeleton. Nucleus. Note=In a filamentous pattern adjacent to the nucleus of migrating cerebellar granule cells. Colocalizes with tubulin and dynein and with the microtubule organizing center. Distributed throughout the cytoplasm of non-migrating cells. A small proportion is nuclear, in a punctate pattern.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUDC gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for NUDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 25468996
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with NUDC: view

Pathways & Interactions for NUDC Gene

genes like me logo Genes that share pathways with NUDC: view

Pathways by source for NUDC Gene

SIGNOR curated interactions for NUDC Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NUDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IBA --
GO:0007049 cell cycle IEA --
GO:0007062 sister chromatid cohesion TAS --
GO:0007067 mitotic nuclear division IEA --
GO:0007275 multicellular organism development TAS 10210332
genes like me logo Genes that share ontologies with NUDC: view

Drugs & Compounds for NUDC Gene

No Compound Related Data Available

Transcripts for NUDC Gene

Unigene Clusters for NUDC Gene

Nuclear distribution C homolog (A. nidulans):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NUDC

Alternative Splicing Database (ASD) splice patterns (SP) for NUDC Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
SP1: - - - - -
SP2: - - -
SP3: - -
SP4: - - - -
SP5:
SP6: -
SP7: - -

Relevant External Links for NUDC Gene

GeneLoc Exon Structure for
NUDC
ECgene alternative splicing isoforms for
NUDC

Expression for NUDC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUDC Gene

Protein differential expression in normal tissues from HIPED for NUDC Gene

This gene is overexpressed in Nasal epithelium (12.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NUDC Gene



Protein tissue co-expression partners for NUDC Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NUDC Gene:

NUDC

SOURCE GeneReport for Unigene cluster for NUDC Gene:

Hs.263812

mRNA Expression by UniProt/SwissProt for NUDC Gene:

Q9Y266-NUDC_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in fetal liver, kidney, lung and brain. Highly expressed in adult pancreas, kidney, skeletal muscle, liver, lung, placenta, prostate, brain and heart.

Evidence on tissue expression from TISSUES for NUDC Gene

  • Skin(4.8)
  • Nervous system(4.8)
  • Lung(4.7)
  • Liver(4.6)
  • Eye(4.5)
  • Heart(4.4)
  • Kidney(4.4)
  • Pancreas(2.9)
  • Bone marrow(2.4)
  • Intestine(2.3)
  • Muscle(2.1)
  • Adrenal gland(2)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with NUDC: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUDC Gene

Orthologs for NUDC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUDC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUDC 34 35
  • 98.49 (n)
dog
(Canis familiaris)
Mammalia NUDC 34 35
  • 91.44 (n)
cow
(Bos Taurus)
Mammalia NUDC 34 35
  • 90.74 (n)
rat
(Rattus norvegicus)
Mammalia Nudc 34
  • 89.02 (n)
mouse
(Mus musculus)
Mammalia Nudc 34 16 35
  • 88.62 (n)
oppossum
(Monodelphis domestica)
Mammalia NUDC 35
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUDC 35
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUDC 34 35
  • 75.43 (n)
lizard
(Anolis carolinensis)
Reptilia NUDC 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nudc 34
  • 68.09 (n)
Str.105 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.4183 34
zebrafish
(Danio rerio)
Actinopterygii nudc 34 35
  • 78.59 (n)
zgc56099 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006117 34
  • 62.33 (n)
fruit fly
(Drosophila melanogaster)
Insecta nudC 34 35
  • 58.74 (n)
CG9710 36
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea nud-1 36 34 35
  • 55.63 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G27890 34
  • 57.79 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.11510 34
rice
(Oryza sativa)
Liliopsida Os06g0231300 34
  • 56.79 (n)
Os.14007 34
wheat
(Triticum aestivum)
Liliopsida Ta.28702 34
bread mold
(Neurospora crassa)
Ascomycetes NCU02588 34
  • 60.93 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5296 35
  • 54 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC19F8.02 34
  • 51.43 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4698 34
Species where no ortholog for NUDC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for NUDC Gene

ENSEMBL:
Gene Tree for NUDC (if available)
TreeFam:
Gene Tree for NUDC (if available)

Paralogs for NUDC Gene

Paralogs for NUDC Gene

(1) SIMAP similar genes for NUDC Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for NUDC Gene

genes like me logo Genes that share paralogs with NUDC: view

Variants for NUDC Gene

Sequence variations from dbSNP and Humsavar for NUDC Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs74315349 Pathogenic 26,913,841(-) TCCCC(C/G/T)GACCC intron-variant, reference, missense, stop-gained
rs74315350 Pathogenic 26,912,036(-) AGGAG(G/T)CTCAC intron-variant, downstream-variant-500B, reference, missense
rs201991593 Likely benign 26,913,409(+) CTCAC(C/G/T)GGGGT intron-variant, reference, missense
rs768288444 Uncertain significance 26,913,819(+) GCCTA(C/T)ATAGG intron-variant, reference, missense
rs1000027339 -- 26,929,358(+) GCTTG(A/G)GCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUDC Gene

Variant ID Type Subtype PubMed ID
esv1159948 CNV insertion 17803354
nsv1000012 CNV gain 25217958
nsv1126984 CNV deletion 24896259
nsv508689 CNV deletion 20534489
nsv834524 CNV gain+loss 17160897

Variation tolerance for NUDC Gene

Residual Variation Intolerance Score: 42.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUDC Gene

Human Gene Mutation Database (HGMD)
NUDC
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUDC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDC Gene

Disorders for NUDC Gene

MalaCards: The human disease database

(1) MalaCards diseases for NUDC Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lissencephaly
- elite association - COSMIC cancer census association via MalaCards
Search NUDC in MalaCards View complete list of genes associated with diseases

Relevant External Links for NUDC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUDC
genes like me logo Genes that share disorders with NUDC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUDC Gene

Publications for NUDC Gene

  1. A role for Plk1 phosphorylation of NudC in cytokinesis. (PMID: 12852857) Zhou T. … Erikson R.L. (Dev. Cell 2003) 3 4 22 64
  2. A homolog of the fungal nuclear migration gene nudC is involved in normal and malignant human hematopoiesis. (PMID: 10210332) Miller B.A. … Osmani S.A. (Exp. Hematol. 1999) 3 4 22 64
  3. Molecular cloning and characterization of the human NUDC gene. (PMID: 10453739) Matsumoto N. … Ledbetter D.H. (Hum. Genet. 1999) 3 4 22 64
  4. Interference RNA (RNAi)-based silencing of endogenous thrombopoietin receptor (Mpl) in Dami cells resulted in decreased hNUDC-mediated megakaryocyte proliferation and differentiation. (PMID: 19560457) Pang S.F. … Xu P. (Exp. Cell Res. 2009) 3 22 64
  5. hNUDC promotes the cell proliferation and differentiation in a leukemic cell line via activation of the thrombopoietin receptor (Mpl). (PMID: 18288130) Tang Y.S. … Xu P. (Leukemia 2008) 3 22 64

Products for NUDC Gene

Sources for NUDC Gene

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