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NUDC Gene

protein-coding   GIFtS: 62
GCID: GC01P027226

NudC Nuclear Distribution Protein

(Previous names: nuclear distribution gene C homolog (A. nidulans), nuclear...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NudC Nuclear Distribution Protein1 2     MNUDC2
Nuclear Distribution Protein C Homolog2 3     NPD0112
Nuclear Distribution C Homolog (A. Nidulans)1     Nuclear Distribution C Homolog2
Nuclear Distribution Gene C Homolog (A. Nidulans)1     Nuclear Distribution Gene C Homolog2
HNUDC2     Nuclear Migration Protein NudC2

External Ids:    HGNC: 80451   Entrez Gene: 107262   Ensembl: ENSG000000902737   OMIM: 6103255   UniProtKB: Q9Y2663   

Export aliases for NUDC gene to outside databases

Previous GC identifers: GC01M028319 GC01P026280 GC01P026481 GC01P026852 GC01P026932 GC01P027120 GC01P025501


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NUDC Gene:
This gene encodes a nuclear distribution protein that plays an essential role in mitosis and cytokinesis. The
encoded protein is involved in spindle formation during mitosis and in microtubule organization during
cytokinesis. Pseudogenes of this gene are found on chromosome 2. (provided by RefSeq, Feb 2012)

GeneCards Summary for NUDC Gene:
NUDC (nudC nuclear distribution protein) is a protein-coding gene. An important paralog of this gene is NUDCD3.

UniProtKB/Swiss-Prot: NUDC_HUMAN, Q9Y266
Function: Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of
mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation

Gene Wiki entry for NUDC Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the NUDC gene promoter:
         AhR   Lmo2   Arnt   C/EBPalpha   CHOP-10   PPAR-gamma1   STAT3   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNUDC promoter sequence
   Search Chromatin IP Primers for NUDC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NUDC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35-p34   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p35-p34

NUDC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUDC gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P027226:  view genomic region     (about GC identifiers)

Start:
27,226,729 bp from pter      End:
27,273,353 bp from pter
Size:
46,625 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NUDC_HUMAN, Q9Y266 (See protein sequence)
Recommended Name: Nuclear migration protein nudC  
Size: 331 amino acids; 38243 Da
Subunit: Binds PLK1. Binds PAFAH1B1 (By similarity). Part of a complex containing PLK1, NUDC, dynein and dynactin
Sequence caution: Sequence=BAA76628.1; Type=Frameshift; Positions=140, 231, 273; Sequence=CAI13560.1;
Type=Erroneous gene model prediction; Sequence=CAI13563.1; Type=Erroneous gene model prediction;
1 PDB 3D structure from and Proteopedia for NUDC:
3QOR (3D)    
Secondary accessions: Q5QP31 Q5QP35 Q9H0N2 Q9Y2B6

Explore the universe of human proteins at neXtProt for NUDC: NX_Q9Y266

Explore proteomics data for NUDC at MOPED

Post-translational modifications: 

  • Reversibly phosphorylated on serine residues during the M phase of the cell cycle. Phosphorylation on Ser-274 and
    Ser-326 is necessary for correct formation of mitotic spindles and chromosome separation during mitosis.
    Phosphorylated by PLK and other kinases1
  • Ubiquitination2 at Lys68, Lys196, Lys250, Lys275, Lys315
  • Modification sites at PhosphoSitePlus

  • See NUDC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006591.1  
    ENSEMBL proteins: 
     ENSP00000404020   ENSP00000319664   ENSP00000400981  
    Reactome Protein details: Q9Y266

    NUDC Human Recombinant Protein Products:

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    antibodies-online proteins for NUDC (5 products) 

     
    antibodies-online peptides for NUDC

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR008978 HSP20-like_chaperone
     IPR007052 CS_dom
     IPR025934 NudC_N_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y266

    ProtoNet protein and cluster: Q9Y266

    1 Blocks protein domain: IPB007052 CS domain

    UniProtKB/Swiss-Prot: NUDC_HUMAN, Q9Y266
    Similarity: Belongs to the nudC family
    Similarity: Contains 1 CS domain


    Find genes that share domains with NUDC           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NUDC_HUMAN, Q9Y266
    Function: Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of
    mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation
    Induction: Up-regulated in actively dividing hematopoietic precursor cells. Up-regulated in cultured
    erythroleukemia TF-1 cells by granulocyte-macrophage colony-stimulating factor. Strongly down-regulated during
    maturation of erythroid precursor cells

         Genatlas biochemistry entry for NUDC:
    nuclear distribution gene C,Aspergillus nidulans and mouse ortholog,widely expressed in fetal and adult
    tissues,coexpressed with LIS1 (PAFAH1B1) in the ventricular zone of developping brain,putatively involved in
    neuronal migration

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with NUDC           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for NUDC

    miRNA
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    miRTarBase miRNAs that target NUDC:
    hsa-mir-484 (MIRT042046), hsa-mir-26b-5p (MIRT030186), hsa-mir-296-3p (MIRT038382), hsa-mir-483-3p (MIRT042392)

    Block miRNA regulation of human, mouse, rat NUDC using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate NUDC:
    hsa-miR-194
    SwitchGear 3'UTR luciferase reporter plasmidNUDC 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NUDC_HUMAN, Q9Y266: Cytoplasm, cytoskeleton. Nucleus. Note=In a filamentous pattern adjacent to the nucleus of
    migrating cerebellar granule cells. Colocalizes with tubulin and dynein and with the microtubule organizing
    center. Distributed throughout the cytoplasm of non-migrating cells. A small proportion is nuclear, in a punctate
    pattern
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol4

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005874microtubule IEA--

    Find genes that share ontologies with NUDC           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NUDC About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    3Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Resolution of Sister Chromatid Cohesion0.92
    4PLK1 signaling events
    PLK1 signaling events
    5Mitotic Telophase/Cytokinesis
    Mitotic Telophase/Cytokinesis


    Find genes that share SuperPaths with NUDC           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for NUDC
        Lissencephaly gene (LIS1) in neuronal migration and development
    PLK1 signaling events


    4 Reactome Pathways for NUDC
        Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Separation of Sister Chromatids
    Mitotic Telophase/Cytokinesis


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NUDC
    Interactions:

        GeneGlobe Interaction Network for NUDC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NUDC (Q9Y2662, 3 ENSP000003196644) via UniProtKB, MINT, STRING, and/or I2D (see all 874)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLK1P533502, 3, ENSP000003000934MINT-7945693 MINT-7947479 I2D: score=3 STRING: ENSP00000300093
    DYNC1H1Q142042, 3MINT-7945693 MINT-7947479 I2D: score=1 
    MAP3K3Q997592, 3MINT-48453 I2D: score=2 
    ENSG00000206454Q018603I2D: score=2 
    ENSG00000229094Q018603I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0007067mitosis IEA--
    GO:0007275multicellular organismal development TAS10210332
    GO:0008283cell proliferation TAS10210332

    Find genes that share ontologies with NUDC           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NUDC



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NUDC gene: 
    NM_006600.3  

    Unigene Cluster for NUDC:

    Nuclear distribution C homolog (A. nidulans)
    Hs.263812  [show with all ESTs]
    Unigene Representative Sequence: BG121847
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000435827 ENST00000321265(uc001bng.1) ENST00000452707 ENST00000484772

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate NUDC:
    hsa-miR-194
    SwitchGear 3'UTR luciferase reporter plasmidNUDC 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat NUDC
      QuantiFast Probe-based Assays in human, mouse, rat NUDC

    Additional mRNA sequence: 

    AB019408.1 AF086922.1 AF100760.1 AF125465.1 AF130736.1 AF241788.1 AL136725.1 BC002399.2 
    BC003132.1 BC006147.1 BC007280.1 BC015153.1 BC021139.1 

    Selected DOTS entries (see all 28):

    DT.99962005  DT.99939309  DT.451875  DT.95173020  DT.100822554  DT.40315649  DT.92455003  DT.120988715 
    DT.95173038  DT.100822557  DT.86856462  DT.100822560  DT.121392790  DT.95173036  DT.100031365  DT.100822547 
    DT.100822556  DT.100822561  DT.121392759  DT.121392776  DT.121392778  DT.121392795  DT.92455012  DT.95173023 

    Selected AceView cDNA sequences (see all 685):

    BQ892863 BQ052361 BU151323 BM912655 CR621608 CA421500 BU156788 BQ887571 
    BM707672 BX463557 BE790600 BQ644952 BQ637922 BC003132 F22224 BQ220967 
    BI870199 AA578146 BU541475 BE311993 CB265541 BC015153 BQ925555 BU632875 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NUDC (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
    SP1:                          -           -     -                 -                       -                           
    SP2:                          -           -                       -                                                   
    SP3:                                      -     -                                                                     
    SP4:                          -     -     -     -                                                                     
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for NUDC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NUDC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGACTGGCCC
    NUDC Expression
    About this image


    NUDC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Thymus (Hematopoietic System)
             Thymus
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Kidney (Urinary System)
             Metanephros
    NUDC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NUDC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.263812

    UniProtKB/Swiss-Prot: NUDC_HUMAN, Q9Y266
    Tissue specificity: Ubiquitous. Highly expressed in fetal liver, kidney, lung and brain. Highly expressed in adult
    pancreas, kidney, skeletal muscle, liver, lung, placenta, prostate, brain and heart

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUDC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NUDC gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nudc1 , 5 nuclear distribution gene C homolog (Aspergillus)1, 5 88.62(n)1
    92.15(a)1
      4 (66.25 cM)5
    182211  NM_010948.31  NP_035078.11 
     1335325425 
    chicken
    (Gallus gallus)
    Aves NUDC1 nuclear distribution C homolog (A. nidulans) 75.43(n)
    81.96(a)
      419578  NM_001006311.1  NP_001006311.1 
    lizard
    (Anolis carolinensis)
    Reptilia NUDC6
    nudC nuclear distribution protein
    78(a)
    1 ↔ 1
    GL343488.1(186128-200680)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.41832 Xenopus laevis transcribed sequence with weak similarity more 75.7(n)    CF549165.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc560992 similar to nuclear distribution gene C homolog (Aspergillus) 76.25(n)   393893  BC045909.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG97103
    nudC1
    nudC1 48(a)3
    58.74(n)1
    54.01(a)1
      73D13
    398791  NM_001259876.11  NP_001246805.11 
    worm
    (Caenorhabditis elegans)
    Secernentea nud-11 , 3 nud-11 49(a)3
    55.63(n)1
    52.23(a)1
      III(13412514-13413669)3
    1767541  NM_067348.61  NP_499749.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G278901 AT4G27890 57.79(n)
    53.25(a)
      828902  NM_118927.4  NP_194518.1 
    rice
    (Oryza sativa)
    Liliopsida Os.140072 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73(n)    AK073934.1 


    ENSEMBL Gene Tree for NUDC (if available)
    TreeFam Gene Tree for NUDC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NUDC gene
    NUDCD32  
    1 SIMAP similar gene for NUDC using alignment to 2 protein entries:     NUDC_HUMAN (see all proteins):
    NUDCD3

    Find genes that share paralogs with NUDC           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for NUDC
    PGOHUM00000258148 PGOHUM00000241033


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NUDC (see all 593)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs120881511,2
    C--27246459(+) TCAGTC/TTGAGG 1 -- us2k12Minor allele frequency- T:0.00NA 4
    rs1863565071,2
    --27246694(+) GACTAC/GAACAG 1 -- us2k10--------
    rs1385215331,2
    --27246706(+) CCGGGC/TGCAGT 1 -- us2k10--------
    rs1913179801,2
    --27246711(+) CGCAGC/TGGCTC 1 -- us2k10--------
    rs1427049291,2
    --27246736(+) AGCGCA/GTTGCG 1 -- us2k10--------
    rs1473613111,2
    --27246844(+) TAGGCA/GTAGTG 1 -- us2k10--------
    rs115841591,2
    H--27246898(+) acctgA/Ggaggc 1 -- us2k10--------
    rs1416640891,2
    C--27246954(+) GCAAC-/AGAGTGA 1 -- us2k10--------
    rs2008294521,2
    C--27247101(+) AGAAA-/TGGGGC 1 -- us2k10--------
    rs1817886401,2
    --27247153(+) CACACC/TTGTAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NUDC (27226729 - 27273353 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for NUDC:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1159948CNV Insertion17803354
    nsv508689CNV Loss20534489
    nsv834524CNV Gain+Loss17160897

    Human Gene Mutation Database (HGMD): NUDC
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NUDC
    DNA2.0 Custom Variant and Variant Library Synthesis for NUDC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610325    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for NUDC:
    Lissencephaly

    Find genes that share disorders with NUDC           About GenesLikeMe

    1 Novoseek inferred disease relationship for NUDC gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoblastic leukemia acute 29.5 2 10210332 (1)


    Export disorders for NUDC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NUDC gene, integrated from 10 sources (see all 67):
    (articles sorted by number of sources associating them with NUDC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A homolog of the fungal nuclear migration gene nudC is involved in normal and malignant human hematopoiesis. (PubMed id 10210332)1, 2, 9 Miller B.A.... Osmani S.A. (Exp. Hematol. 1999)
    2. A role for Plk1 phosphorylation of NudC in cytokinesis. (PubMed id 12852857)1, 2, 9 Zhou T.... Erikson R.L. (Dev. Cell 2003)
    3. Molecular cloning and characterization of the human NUDC gene. (PubMed id 10453739)1, 2, 9 Matsumoto N. and Ledbetter D.H. (Hum. Genet. 1999)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Role for NudC, a dynein-associated nuclear movement protein, in mitosis and cytokinesis. (PubMed id 12679384)1, 2 Aumais J.P.... Yu-Lee L.-Y. (J. Cell Sci. 2003)
    8. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    9. A microtubule associated protein (hNUDC) binds to the extracellular domain of thrombopoietin receptor (Mpl). (PubMed id 16088917)1, 9 Pan R.M....Xu P. (J. Cell. Biochem. 2005)
    10. NudC is required for Plk1 targeting to the kinetochore and chromosome congression. (PubMed id 16860740)1, 9 Nishino M....Yu-Lee L.Y. (Curr. Biol. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10726 HGNC: 8045 AceView: NUDC Ensembl:ENSG00000090273 euGenes: HUgn10726
    ECgene: NUDC H-InvDB: NUDC

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NUDC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NUDC gene:
    Search GeneIP for patents involving NUDC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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