NUCKS1 Gene
protein-coding GIFtS: 50
GCID: GC01M205681
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|
nuclear casein kinase and cyclin-dependent kinase substrate...
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Aliases
for NUCKS1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nuclear Casein Kinase And Cyclin-Dependent Kinase Substrate 11 2 | | NUCKS1 2 3 5 | | P12 3 | | Nuclear Ubiquitous Casein And Cyclin-Dependent Kinase Substrate 12 | | Nuclear Ubiquitous Casein Kinase And Cyclin-Dependent Kinase Substrate2 | | Potential LAG1 Interactor2 |
Export aliases for NUCKS1 gene to outside databasesPrevious GC identifers: GC01M202419 GC01M203948 GC01M176846 |
Summaries
for NUCKS1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NUCKS1:
This gene encodes a nuclear protein that is highly conserved in vertebrates. The conserved regions of the proteincontain several consensus phosphorylation sites for casein kinase II and cyclin-dependent kinases, two putativenuclear localization signals, and a basic DNA-binding domain. It is phosphorylated in vivo by Cdk1 during mitosis ofthe cell cycle. (provided by RefSeq, Aug 2010)
Gene Wiki entry for NUCKS1
|
Genomic Views
for NUCKS1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NUCKS1 gene promoter:
Spz1 p53
Other transcription factors
Search SABiosciences Chromatin IP Primers for NUCKS1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUCKS1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q32.1 Ensembl cytogenetic band: 1q32.1 HGNC cytogenetic band: 1q32.1NUCKS1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M205681: view genomic region
(about GC identifiers)
Start:
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205,681,947 bp from pter |
End:
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205,719,404 bp from pter |
Size:
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37,458 bases |
Orientation:
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minus strand |
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Proteins
for NUCKS1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NUCKS_HUMAN, Q9H1E3 (See
protein sequence)Recommended Name: Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 Size: 243 amino acids; 27296 Da
Subcellular location: Nucleus
Sequence caution: Sequence=BAB15076.1; Type=Erroneous termination; Positions=164; Note=Translated as Arg;Sequence=CAC20412.1; Type=Erroneous gene model prediction;
Secondary accessions: Q54AC0 Q5PXE7 Q9H1D6 Q9H723Alternative splicing: 2 isoforms: Q9H1E3-1 Q9H1E3-2 Explore the universe of human proteins at neXtProt for NUCKS1: NX_Q9H1E3
Post-translational modifications:
Phosphorylated by CDK1 and casein kinase1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H1E3
NUCKS1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_073568.2
ENSEMBL proteins: ENSP00000356110
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
NUCKS1 for ontologies About GeneDecksing
NUCKS1 Antibody Products:
Assay Products for NUCKS1: |
Protein
Domains /
Families
for NUCKS1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NUCKS1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9H1E3ProtoNet protein and cluster: Q9H1E3 |
Function
for NUCKS1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUCKS1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUCKS1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUCKS1 |
1 GenomeRNAi human phenotype for NUCKS1:
|
Pathways & Interactions
for NUCKS1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NUCKS1
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5/10 Interacting proteins for NUCKS1 (Q9H1E32, 3 ENSP000003561104) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
|
Drugs & Compounds
for NUCKS1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NUCKS1
Search CenterWatch for drugs/clinical trials and news about NUCKS1 / NUCKS
|
Transcripts
for NUCKS1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NUCKS1 gene: NM_022731.4 Unigene Cluster for NUCKS1: Nuclear casein kinase and cyclin-dependent kinase substrate 1 Hs.213061 [show with all ESTs]Unigene Representative Sequence: NM_0227312 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000367142(uc001hdb.3) ENST00000464938
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUCKS1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUCKS1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NUCKS1 (NM_022731) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NUCKS1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUCKS1 |
Additional cDNA sequence: AB049824.1 AF130080.2 AJ012584.1 AK025133.1 AK056578.1 AK095855.1 AK225228.1 AK300416.1 AK311186.1 AY823399.1 BC000805.1 BC016311.1 BC025313.1 BC039469.1 BC067224.1 BC107728.1 CR457339.1 24/62 DOTS entries (see all 62): DT.100045200 DT.95216577 DT.91782357 DT.95328755 DT.91782327 DT.101969329 DT.121456164 DT.95216514 DT.100677827 DT.100646744 DT.121456338 DT.100850587 DT.86998921 DT.40205328 DT.121456251 DT.95133072 DT.121456183 DT.100045199 DT.121447781 DT.121456168 DT.121456206 DT.121456232 DT.91782335 DT.91782343 24/1194 AceView cDNA sequences (see all 1194): AA137266 BQ222104 CB161182 AW731725 T35546 AV654738 CD677383 BU947591 F08896 Z40337 AW664184 BU177312 BU166222 AW591993 AI707982 CD722352 AI340018 BQ218347 AW612312 AA476605 AW195660 BM834485 F27998 BQ775754
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for NUCKS1 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 |
|---|
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| SP1: | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NUCKS1
|
Expression
for NUCKS1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NUCKS1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAGATGTGG
About this image
See NUCKS1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NUCKS1
SOURCE GeneReport for Unigene cluster: Hs.213061
UniProtKB/Swiss-Prot: NUCKS_HUMAN, Q9H1E3Tissue specificity: Widely expressed, with highest levels in thyroid gland, prostate and uterus and in fetal liver,thymus and lung
SABiosciences Custom PCR Arrays for NUCKS1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUCKS1
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUCKS1 |
Orthologs
for NUCKS1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for NUCKS1 gene from 4/14 species (see all 14) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
NUCKS11 |
nuclear casein kinase and cyclin-dependent kinase substrate more |
80.72(n)
85.54(a) |
|
404775 NM_213581.1 NP_998746.1 |
lizard
(Anolis carolinensis) |
Reptilia |
NUCKS16 |
-- |
73(a) |
1 ↔ 1 |
GL343228.1(600010-632085) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
MGC757382 |
hypothetical protein MGC75738 |
76.75(n) |
|
BC063335.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
nucks1a1 |
nuclear casein kinase and cyclin-dependent kinase substrate more |
64.03(n)
63.75(a) |
|
447862 NM_001004601.1 NP_001004601.1 |
ENSEMBL Gene Tree for NUCKS1 (if available)
TreeFam Gene Tree for NUCKS1 (if available) |
Paralogs
for NUCKS1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NUCKS1 gene
- RAD51AP12
1 SIMAP similar gene for NUCKS1 using alignment to 1 protein entry: NUCKS_HUMAN:NUCKS
NUCKS1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for NUCKS1
PGOHUM00000261298
|
Genomic Variants
for NUCKS1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NUCKS1 (205681947 - 205719404 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NUCKS1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NUCKS1 |
|
Disorders
/ Diseases
for NUCKS1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NUCKS1 for disorders About GeneDecksing
OMIM gene information: 611912
OMIM disorders: --
13  diseases for NUCKS1: About MalaCardssystemic lupus erythematosus lupus erythematosus breast fibroadenoma adenocarcinoma
parkinson's disease lung adenocarcinoma breast adenocarcinoma breast cancer
retinitis prostatitis schizophrenia carcinoma
thyroiditis
Human Genome Epidemiology (HuGE) Navigator: NUCKS1 (4 documents)
Export disorders for NUCKS1 gene to outside databases
|
Publications
for NUCKS1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NUCKS1 gene, integrated from 9 sources (see all 49):
(articles sorted by number of sources associating them with NUCKS1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning of a mammalian nuclear phosphoprotein NUCKS, which serves as a substrate for Cdk1 in vivo. (PubMed id 11298763)1, 2, 3 Oestvold A.C....Grundt K. (2001)
- Characterisation of the NUCKS gene on human chromosome 1q32.1 and the presence of a homologous gene in different species. (PubMed id 15381070)1, 2, 9 Grundt K....Ostvold A.C. (2004)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- NUCKS overexpression in breast cancer. (PubMed id 19664271)1, 9 Drosos Y....Aleporou-Marinou V. (2009)
- A putative DNA-binding domain in the NUCKS protein. (PubMed id 12413487)1, 9 Grundt K....Ostvold A.C. (2002)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
|
External Searches for NUCKS1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NUCKS1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NUCKS1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NUCKS1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NUCKS1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NUCKS1 gene:
Search GeneIP for patents involving NUCKS1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NUCKS1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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