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Aliases for NUCKS1 Gene

Aliases for NUCKS1 Gene

  • Nuclear Casein Kinase And Cyclin-Dependent Kinase Substrate 1 2 3
  • NUCKS 3 4 6
  • P1 3 4
  • Nuclear Ubiquitous Casein Kinase And Cyclin-Dependent Kinase Substrate 3
  • Nuclear Ubiquitous Casein And Cyclin-Dependent Kinase Substrate 1 3
  • Potential LAG1 Interactor 3
  • JC7 3

External Ids for NUCKS1 Gene

Previous GeneCards Identifiers for NUCKS1 Gene

  • GC01M202419
  • GC01M203948
  • GC01M176846

Summaries for NUCKS1 Gene

Entrez Gene Summary for NUCKS1 Gene

  • This gene encodes a nuclear protein that is highly conserved in vertebrates. The conserved regions of the protein contain several consensus phosphorylation sites for casein kinase II and cyclin-dependent kinases, two putative nuclear localization signals, and a basic DNA-binding domain. It is phosphorylated in vivo by Cdk1 during mitosis of the cell cycle. [provided by RefSeq, Aug 2010]

GeneCards Summary for NUCKS1 Gene

NUCKS1 (Nuclear Casein Kinase And Cyclin-Dependent Kinase Substrate 1) is a Protein Coding gene.

Gene Wiki entry for NUCKS1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUCKS1 Gene

Genomics for NUCKS1 Gene

Regulatory Elements for NUCKS1 Gene

Transcription factor binding sites by QIAGEN in the NUCKS1 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NUCKS1 Gene

Start:
205,712,819 bp from pter
End:
205,750,276 bp from pter
Size:
37,458 bases
Orientation:
Minus strand

Genomic View for NUCKS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUCKS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUCKS1 Gene

Proteins for NUCKS1 Gene

  • Protein details for NUCKS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1E3-NUCKS_HUMAN
    Recommended name:
    Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1
    Protein Accession:
    Q9H1E3
    Secondary Accessions:
    • Q54AC0
    • Q5PXE7
    • Q9H1D6
    • Q9H723

    Protein attributes for NUCKS1 Gene

    Size:
    243 amino acids
    Molecular mass:
    27296 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15076.1; Type=Erroneous termination; Positions=164; Note=Translated as Arg.; Evidence={ECO:0000305}; Sequence=CAC20412.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for NUCKS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUCKS1 Gene

Proteomics data for NUCKS1 Gene at MOPED

Post-translational modifications for NUCKS1 Gene

Other Protein References for NUCKS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NUCKS1 Gene

Domains for NUCKS1 Gene

Protein Domains for NUCKS1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NUCKS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NUCKS1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for NUCKS1 Gene

Function for NUCKS1 Gene

Gene Ontology (GO) - Molecular Function for NUCKS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with NUCKS1: view

Phenotypes for NUCKS1 Gene

GenomeRNAi human phenotypes for NUCKS1:
genes like me logo Genes that share phenotypes with NUCKS1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NUCKS1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NUCKS1 Gene

Localization for NUCKS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUCKS1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUCKS1 Gene COMPARTMENTS Subcellular localization image for NUCKS1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for NUCKS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA 17604136
genes like me logo Genes that share ontologies with NUCKS1: view

Pathways for NUCKS1 Gene

SuperPathways for NUCKS1 Gene

No Data Available

Interacting Proteins for NUCKS1 Gene

Gene Ontology (GO) - Biological Process for NUCKS1 Gene

None

No data available for Pathways by source for NUCKS1 Gene

Transcripts for NUCKS1 Gene

mRNA/cDNA for NUCKS1 Gene

Unigene Clusters for NUCKS1 Gene

Nuclear casein kinase and cyclin-dependent kinase substrate 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NUCKS1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NUCKS1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUCKS1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1:
SP2:

Relevant External Links for NUCKS1 Gene

GeneLoc Exon Structure for
NUCKS1
ECgene alternative splicing isoforms for
NUCKS1

Expression for NUCKS1 Gene

mRNA expression in normal human tissues for NUCKS1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUCKS1 Gene

SOURCE GeneReport for Unigene cluster for NUCKS1 Gene Hs.213061

mRNA Expression by UniProt/SwissProt for NUCKS1 Gene

Q9H1E3-NUCKS_HUMAN
Tissue specificity: Widely expressed, with highest levels in thyroid gland, prostate and uterus and in fetal liver, thymus and lung.
genes like me logo Genes that share expressions with NUCKS1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NUCKS1 Gene

Orthologs for NUCKS1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NUCKS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUCKS1 35
  • 99.73 (n)
  • 100 (a)
NUCKS1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NUCKS1 35
  • 92.73 (n)
  • 96.71 (a)
NUCKS1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUCKS1 35
  • 92.87 (n)
  • 96.3 (a)
NUCKS1 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nucks1 35
  • 90.6 (n)
  • 94.44 (a)
Nucks1 16
Nucks1 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 76 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia NUCKS1 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nucks1 35
  • 90.81 (n)
  • 95.06 (a)
chicken
(Gallus gallus)
Aves NUCKS1 35
  • 84.57 (n)
  • 93.39 (a)
NUCKS1 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUCKS1 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75738 35
nucks1 35
  • 72.15 (n)
  • 73.84 (a)
zebrafish
(Danio rerio)
Actinopterygii nucks1a 35
  • 59.78 (n)
  • 57.85 (a)
nucks1a 36
  • 48 (a)
OneToMany
nucks1b 36
  • 39 (a)
OneToMany
Species with no ortholog for NUCKS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUCKS1 Gene

ENSEMBL:
Gene Tree for NUCKS1 (if available)
TreeFam:
Gene Tree for NUCKS1 (if available)

Paralogs for NUCKS1 Gene

Selected SIMAP similar genes for NUCKS1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for NUCKS1 Gene

genes like me logo Genes that share paralogs with NUCKS1: view

No data available for Paralogs for NUCKS1 Gene

Variants for NUCKS1 Gene

Sequence variations from dbSNP and Humsavar for NUCKS1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3805 -- 205,714,227(+) GGGCA(A/G/T)AAGCT utr-variant-3-prime
rs14797 -- 205,719,657(+) AAATC(C/T)TCATC reference, synonymous-codon
rs823092 -- 205,718,745(+) TGTAA(A/T)GAAGA intron-variant
rs823093 -- 205,720,099(-) TTAAT(C/T)CTATG intron-variant
rs823094 -- 205,720,679(+) TGATA(G/T)AATGA intron-variant

Relevant External Links for NUCKS1 Gene

HapMap Linkage Disequilibrium report
NUCKS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NUCKS1 Gene

Disorders for NUCKS1 Gene

Relevant External Links for NUCKS1

Genetic Association Database (GAD)
NUCKS1
Human Genome Epidemiology (HuGE) Navigator
NUCKS1
genes like me logo Genes that share disorders with NUCKS1: view

No data available for UniProtKB/Swiss-Prot for NUCKS1 Gene

Publications for NUCKS1 Gene

  1. Characterisation of the NUCKS gene on human chromosome 1q32.1 and the presence of a homologous gene in different species. (PMID: 15381070) Grundt K. … Ostvold A.C. (Biochem. Biophys. Res. Commun. 2004) 3 4 23
  2. Molecular cloning of a mammalian nuclear phosphoprotein NUCKS, which serves as a substrate for Cdk1 in vivo. (PMID: 11298763) Oestvold A.C. … Grundt K. (Eur. J. Biochem. 2001) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. NUCKS overexpression in breast cancer. (PMID: 19664271) Drosos Y. … Aleporou-Marinou V. (Cancer Cell Int. 2009) 3 23
  5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4

Products for NUCKS1 Gene

Sources for NUCKS1 Gene

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